Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "900", "sentence": "Dexamethasone may be superior to prednisone in conventional equi-effective doses.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "901", "sentence": "Blast sensitivity to glucocorticoids correlates closely with sensitivity to other, putatively non-cross-resisting agents and with outcome after multi-agent therapy , suggesting overlapping mechanisms of action, and focusing attention on the determinants of the threshold for apoptosis .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "902", "sentence": "Increasing success in the treatment of childhood acute lymphoblastic leukemia has led to increasing awareness of avascular necrosis of bone as a potentially disabling sequela of glucocorticoid therapy , especially in adolescent and young adult patients .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "903", "sentence": "Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1 .", "label": " ( protein: PU.1, None) , ( protein: J kappa, None) , ( protein: Epstein-Barr virus nuclear protein 2, None) , ( DNA: latent membrane protein 1 promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PU.1, None) , ( protein: J kappa, None) , ( protein: Epstein-Barr virus nuclear protein 2, None) , ( DNA: latent membrane protein 1 promoter, None) " }

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{ "id": "904", "sentence": "Expression of the Epstein-Barr virus ( EBV ) latent membrane protein 1 ( LMP-1 ) oncogene is regulated by the EBV nuclear protein 2 ( EBNA-2 ) transactivator .", "label": " ( protein: LMP-1, None) , ( protein: EBV nuclear protein 2 ( EBNA-2 ) transactivator, None) , ( protein: latent membrane protein 1, None) , ( DNA: Epstein-Barr virus ( EBV ) latent membrane protein 1 ( LMP-1 ) oncogene, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LMP-1, None) , ( protein: EBV nuclear protein 2 ( EBNA-2 ) transactivator, None) , ( protein: latent membrane protein 1, None) , ( DNA: Epstein-Barr virus ( EBV ) latent membrane protein 1 ( LMP-1 ) oncogene, None) , ( protein: EBNA-2, None) " }

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{ "id": "905", "sentence": "EBNA-2 is known to interact with the cellular DNA-binding protein J kappa and is recruited to promoters containing the GTGGGAA J kappa recognition sequence .", "label": " ( DNA: J kappa recognition sequence, None) , ( protein: EBNA-2, None) , ( protein: J kappa, None) , ( protein: J kappa, None) , ( protein: cellular DNA-binding protein, None) , ( DNA: promoters, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: J kappa recognition sequence, None) , ( protein: EBNA-2, None) , ( protein: J kappa, None) , ( protein: J kappa, None) , ( protein: cellular DNA-binding protein, None) , ( DNA: promoters, None) " }

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{ "id": "906", "sentence": "The minimal EBNA-2 -responsive LMP-1 promoter includes one J kappa -binding site , and we now show that mutation of that site, such that J kappa cannot bind, reduces EBNA-2 responsiveness by 60%.", "label": " ( DNA: J kappa -binding site, None) , ( DNA: minimal EBNA-2 -responsive LMP-1 promoter, None) , ( protein: EBNA-2, None) , ( protein: J kappa, None) , ( protein: J kappa, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: J kappa -binding site, None) , ( DNA: minimal EBNA-2 -responsive LMP-1 promoter, None) , ( protein: EBNA-2, None) , ( protein: J kappa, None) , ( protein: J kappa, None) , ( protein: EBNA-2, None) " }

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{ "id": "907", "sentence": "To identify other factors which interact with the LMP-1 EBNA-2 response element ( E2RE ), a -236/-145 minimal E2RE was used as a probe in an electrophoretic mobility shift assay .", "label": " ( DNA: E2RE, None) , ( protein: EBNA-2, None) , ( DNA: LMP-1 EBNA-2 response element, None) , ( DNA: -236/-145 minimal E2RE, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: E2RE, None) , ( protein: EBNA-2, None) , ( DNA: LMP-1 EBNA-2 response element, None) , ( DNA: -236/-145 minimal E2RE, None) " }

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{ "id": "908", "sentence": "The previously characterized factors J kappa , PU.1 , and AML1 bind to the LMP-1 E2RE , along with six other unidentified factors ( LBF2 to LBF7 ).", "label": " ( DNA: LMP-1 E2RE, None) , ( protein: LBF7, None) , ( protein: AML1, None) , ( protein: LBF2, None) , ( protein: PU.1, None) , ( protein: J kappa, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LMP-1 E2RE, None) , ( protein: LBF7, None) , ( protein: AML1, None) , ( protein: LBF2, None) , ( protein: PU.1, None) , ( protein: J kappa, None) " }

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{ "id": "909", "sentence": "Binding sites were mapped for each factor.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "910", "sentence": "LBF4 is B- and T-cell specific and recognizes the PU.1 GGAA core sequence as shown by methylation interference .", "label": " ( protein: LBF4, None) , ( DNA: PU.1 GGAA core sequence, None) , ( protein: PU.1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LBF4, None) , ( DNA: PU.1 GGAA core sequence, None) , ( protein: PU.1, None) " }

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{ "id": "911", "sentence": "LBF4 has a molecular mass of 105 kDa and is probably unrelated to PU.1 .", "label": " ( protein: PU.1, None) , ( protein: LBF4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PU.1, None) , ( protein: LBF4, None) " }

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{ "id": "912", "sentence": "LBF2 was found only in epithelial cell lines , whereas LBF3 , LBF5 , LBF6 , and LBF7 were not cell type specific.", "label": " ( protein: LBF2, None) , ( protein: LBF6, None) , ( cell line: epithelial cell lines, None) , ( protein: LBF3, None) , ( protein: LBF5, None) , ( protein: LBF7, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LBF2, None) , ( protein: LBF6, None) , ( cell line: epithelial cell lines, None) , ( protein: LBF3, None) , ( protein: LBF5, None) , ( protein: LBF7, None) " }

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{ "id": "913", "sentence": "Mutations of the AML1- or LBF4- binding sites had no effect on EBNA-2 transactivation , whereas mutation of the PU.1 -binding site completely eliminated EBNA-2 responses .", "label": " ( protein: PU.1, None) , ( protein: EBNA-2, None) , ( DNA: PU.1 -binding site, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PU.1, None) , ( protein: EBNA-2, None) , ( DNA: PU.1 -binding site, None) , ( protein: EBNA-2, None) " }

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{ "id": "914", "sentence": "A gst- EBNA-2 fusion protein specifically depleted PU.1 from nuclear extracts and bound in vitro translated PU.1 , providing biochemical evidence for a direct EBNA-2 -PU.1 interaction.", "label": " ( protein: PU.1, None) , ( protein: EBNA-2, None) , ( protein: -PU.1, None) , ( protein: PU.1, None) , ( protein: gst- EBNA-2 fusion protein, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PU.1, None) , ( protein: EBNA-2, None) , ( protein: -PU.1, None) , ( protein: PU.1, None) , ( protein: gst- EBNA-2 fusion protein, None) , ( protein: EBNA-2, None) " }

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{ "id": "915", "sentence": "Thus, EBNA-2 transactivation of the LMP-1 promoter is dependent on interaction with at least two distinct sequence-specific DNA-binding proteins , J kappa and PU.1 .", "label": " ( protein: PU.1, None) , ( DNA: LMP-1 promoter, None) , ( protein: DNA-binding proteins, None) , ( protein: J kappa, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PU.1, None) , ( DNA: LMP-1 promoter, None) , ( protein: DNA-binding proteins, None) , ( protein: J kappa, None) , ( protein: EBNA-2, None) " }

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{ "id": "916", "sentence": "LBF3 , LBF5 , LBF6 , or LBF7 may also be involved, since their binding sites also contribute to EBNA-2 responsiveness .", "label": " ( protein: LBF5, None) , ( protein: LBF6, None) , ( protein: LBF3, None) , ( protein: LBF7, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LBF5, None) , ( protein: LBF6, None) , ( protein: LBF3, None) , ( protein: LBF7, None) , ( protein: EBNA-2, None) " }

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{ "id": "917", "sentence": "Lymphocyte glucocorticoid receptor : predictor of sertraline response in adolescent major depressive disorder ( MDD ).", "label": " ( protein: Lymphocyte glucocorticoid receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Lymphocyte glucocorticoid receptor, None) " }

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{ "id": "918", "sentence": "Major depressive disorder ( MDD ) in adolescents demonstrates resistance to tricyclic antidepressants and absence of hypercortisolemia .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "919", "sentence": "The efficacy of serotonin reuptake inhibitors ( SRIs ) is uncertain, and response predictors are unavailable.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "920", "sentence": "Abnormal fast feedback and negative feedback of the hypothalamic-pituitary-adrenal axis implicates a dampened limbic-hippocampal glucocorticoid type II receptor ( GCII ).", "label": " ( protein: limbic-hippocampal glucocorticoid type II receptor, None) , ( protein: GCII, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: limbic-hippocampal glucocorticoid type II receptor, None) , ( protein: GCII, None) " }

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{ "id": "921", "sentence": "We hypothesized that lymphocyte GCII is altered in adolescent MDD and could serve as a marker for response to SRIs .", "label": " ( protein: lymphocyte GCII, None) , ( protein: GCII, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: lymphocyte GCII, None) , ( protein: GCII, None) " }

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{ "id": "922", "sentence": "In an open-label study, adolescents (n = 20) meeting DSM-III-R criteria for MDD showed baseline lymphocyte GCII sites per cell (sites/cell) values of 793 +/- 106 versus 2,563 +/- 499 (+/- SEM) for matched controls (n = 18) (t = 3.5; df = 36; p < .001).", "label": " ( protein: GCII, None) , ( protein: lymphocyte GCII sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCII, None) , ( protein: lymphocyte GCII sites, None) " }

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{ "id": "923", "sentence": "GCII was bimodally distributed, with SRI responders differing from nonresponders (t = 3.9; df = 14; p < .001).", "label": " ( protein: GCII, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCII, None) " }

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{ "id": "924", "sentence": "GCII accurately classified 90 percent of sertraline responders and 80 percent of nonresponders.", "label": " ( protein: GCII, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCII, None) " }

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{ "id": "925", "sentence": "Only SRI responders showed GCII sites/cell upregulated after 6 weeks of treatment (t = 2.1, df = 10; p < .05).", "label": " ( protein: GCII, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCII, None) " }

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{ "id": "926", "sentence": "The role of NFATp in cyclosporin A-sensitive tumor necrosis factor -alpha gene transcription .", "label": " ( protein: cyclosporin A-sensitive tumor necrosis factor, None) , ( protein: NFATp, None) , ( DNA: cyclosporin A-sensitive tumor necrosis factor -alpha gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cyclosporin A-sensitive tumor necrosis factor, None) , ( protein: NFATp, None) , ( DNA: cyclosporin A-sensitive tumor necrosis factor -alpha gene, None) " }

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{ "id": "927", "sentence": "The tumor necrosis factor-alpha ( TNF alpha) gene is an immediate early gene in activated T cells , in that it is rapidly induced without a requirement for protein synthesis .", "label": " ( protein: TNF, None) , ( cell type: T cells, None) , ( protein: tumor necrosis factor-alpha, None) , ( DNA: tumor necrosis factor-alpha ( TNF alpha) gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF, None) , ( cell type: T cells, None) , ( protein: tumor necrosis factor-alpha, None) , ( DNA: tumor necrosis factor-alpha ( TNF alpha) gene, None) " }

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{ "id": "928", "sentence": "Maximal induction of TNF alpha mRNA can be induced by treatment of T cells with calcium ionophores alone, via a calcineurin -dependent process that is blocked by cyclosporin A .", "label": " ( RNA: TNF alpha mRNA, None) , ( protein: calcineurin, None) , ( protein: TNF, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: TNF alpha mRNA, None) , ( protein: calcineurin, None) , ( protein: TNF, None) , ( cell type: T cells, None) " }

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{ "id": "929", "sentence": "We have previously identified a promoter element , kappa 3 , that is required for calcium-stimulated, cyclosporin A -sensitive induction of the TNF alpha gene in activated T cells .", "label": " ( DNA: TNF alpha gene, None) , ( DNA: promoter element, None) , ( DNA: kappa 3, None) , ( cell type: T cells, None) , ( protein: TNF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: TNF alpha gene, None) , ( DNA: promoter element, None) , ( DNA: kappa 3, None) , ( cell type: T cells, None) , ( protein: TNF, None) " }

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{ "id": "930", "sentence": "Here, we demonstrate that the kappa 3 binding factor contains NFATp , a cyclosporin-sensitive DNA-binding protein required for interleukin-2 gene transcription .", "label": " ( DNA: kappa 3, None) , ( protein: NFATp, None) , ( protein: kappa 3 binding factor, None) , ( protein: cyclosporin-sensitive DNA-binding protein, None) , ( DNA: interleukin-2 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: kappa 3, None) , ( protein: NFATp, None) , ( protein: kappa 3 binding factor, None) , ( protein: cyclosporin-sensitive DNA-binding protein, None) , ( DNA: interleukin-2 gene, None) " }

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{ "id": "931", "sentence": "NFATp binds to two sites within the kappa 3 element , and occupancy of both sites is required for TNF alpha gene induction .", "label": " ( DNA: kappa 3, None) , ( DNA: kappa 3 element, None) , ( protein: NFATp, None) , ( protein: TNF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: kappa 3, None) , ( DNA: kappa 3 element, None) , ( protein: NFATp, None) , ( protein: TNF, None) " }

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{ "id": "932", "sentence": "Thus, although the kappa 3 element has little sequence similarity to other NFATp -binding sites , it appears to function as a cyclosporin-sensitive promoter element in T cells by virtue of its ability to bind NFATp .", "label": " ( protein: NFATp, None) , ( DNA: kappa 3 element, None) , ( protein: NFATp, None) , ( DNA: NFATp -binding sites, None) , ( cell type: T cells, None) , ( DNA: cyclosporin-sensitive promoter element, None) , ( DNA: kappa 3, None) , ( DNA: promoter element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NFATp, None) , ( DNA: kappa 3 element, None) , ( protein: NFATp, None) , ( DNA: NFATp -binding sites, None) , ( cell type: T cells, None) , ( DNA: cyclosporin-sensitive promoter element, None) , ( DNA: kappa 3, None) , ( DNA: promoter element, None) " }

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{ "id": "933", "sentence": "The involvement of NFATp in transcriptional activation of both the interleukin-2 and TNF alpha genes suggests that this factor plays an important role in the coordinate induction of multiple cytokine genes , starting at the earliest stages of T cell activation .", "label": " ( protein: TNF alpha, None) , ( protein: interleukin-2, None) , ( DNA: TNF alpha genes, None) , ( DNA: cytokine genes, None) , ( protein: NFATp, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF alpha, None) , ( protein: interleukin-2, None) , ( DNA: TNF alpha genes, None) , ( DNA: cytokine genes, None) , ( protein: NFATp, None) " }

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{ "id": "934", "sentence": "Regulation and specificity of MNDA expression in monocytes , macrophages , and leukemia/B lymphoma cell lines .", "label": " ( cell type: monocytes, None) , ( protein: MNDA, None) , ( cell type: macrophages, None) , ( cell line: leukemia/B lymphoma cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytes, None) , ( protein: MNDA, None) , ( cell type: macrophages, None) , ( cell line: leukemia/B lymphoma cell lines, None) " }

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{ "id": "935", "sentence": "The expression of the human myeloid cell nuclear differentiation antigen ( MNDA ) was observed specifically in cells of the granulocyte-macrophage lineage in our earlier reports.", "label": " ( protein: human myeloid cell nuclear differentiation antigen, None) , ( protein: MNDA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: human myeloid cell nuclear differentiation antigen, None) , ( protein: MNDA, None) " }

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{ "id": "936", "sentence": "The specificity of MNDA expression for cells in the granulocyte-macrophage lineage was reexamined in cell lines established from patients with Philadelphia chromosome-positive chronic myeloid leukemia .", "label": " ( cell line: cell lines, None) , ( protein: MNDA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: cell lines, None) , ( protein: MNDA, None) " }

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{ "id": "937", "sentence": "Cell lines that expressed MNDA exhibited myeloid cell features and granulocyte or monocyte differentiation could be induced in vitro, while cell lines exhibiting properties of very early stage cells or multipotential cells did not express MNDA .", "label": " ( protein: MNDA, None) , ( cell type: multipotential cells, None) , ( protein: MNDA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MNDA, None) , ( cell type: multipotential cells, None) , ( protein: MNDA, None) " }

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{ "id": "938", "sentence": "Cells originating from cases of Burkitt's lymphoma were negative.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "939", "sentence": "By contrast, three lymphoblastoid cell lines (immortalized in vitro with Epstein-Barr virus ) were weakly positive and MNDA was up-regulated by interferon-alpha ( IFN-alpha ) treatment .", "label": " ( protein: MNDA, None) , ( cell line: lymphoblastoid cell lines, None) , ( protein: IFN-alpha, None) , ( protein: interferon-alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MNDA, None) , ( cell line: lymphoblastoid cell lines, None) , ( protein: IFN-alpha, None) , ( protein: interferon-alpha, None) " }

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{ "id": "940", "sentence": "As we reported previously, MNDA mRNA level in adherent monocytes is elevated by IFN-alpha ; in this study, we further assessed MNDA expression in in vitro monocyte-derived macrophages .", "label": " ( cell type: macrophages, None) , ( RNA: MNDA mRNA, None) , ( cell type: monocytes, None) , ( protein: MNDA, None) , ( protein: MNDA, None) , ( protein: IFN-alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: macrophages, None) , ( RNA: MNDA mRNA, None) , ( cell type: monocytes, None) , ( protein: MNDA, None) , ( protein: MNDA, None) , ( protein: IFN-alpha, None) " }

[]

{ "id": "941", "sentence": "Three additional agents ( endotoxin , phytohemagglutinin , and phorbol ester ) and other conditions that affect function, cytokine production , differentiation , and/or growth of monocytes were examined for their ability to alter MNDA expression .", "label": " ( protein: MNDA, None) , ( protein: cytokine, None) , ( cell type: monocytes, None) , ( protein: phytohemagglutinin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MNDA, None) , ( protein: cytokine, None) , ( cell type: monocytes, None) , ( protein: phytohemagglutinin, None) " }

[]

{ "id": "942", "sentence": "The results varied with the agent, cell type, and stage of differentiation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "943", "sentence": "Changes in MNDA expression occurred slowly (hours to days), suggesting that MNDA could mediate changes realized over a long period.", "label": " ( protein: MNDA, None) , ( protein: MNDA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MNDA, None) , ( protein: MNDA, None) " }

[]

{ "id": "944", "sentence": "The results also reveal a discordance in certain MNDA positive cells between steady-state levels or changes in levels of protein and mRNA indicating that the regulation of MNDA expression occurs at more than one point.", "label": " ( RNA: mRNA, None) , ( protein: MNDA, None) , ( cell line: MNDA positive cells, None) , ( protein: MNDA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: mRNA, None) , ( protein: MNDA, None) , ( cell line: MNDA positive cells, None) , ( protein: MNDA, None) " }

[]

{ "id": "945", "sentence": "Changes in MNDA expression are consistent with a role in opposing macrophage differentiation and activation of monocytes /macrophages .", "label": " ( protein: MNDA, None) , ( cell type: /macrophages, None) , ( cell type: monocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MNDA, None) , ( cell type: /macrophages, None) , ( cell type: monocytes, None) " }

[]

{ "id": "946", "sentence": "DNA-binding studies of the Epstein-Barr virus nuclear antigen 2 ( EBNA-2 ): evidence for complex formation by latent membrane protein gene promoter-binding proteins in EBNA-2 -positive cell lines .", "label": " ( cell line: EBNA-2 -positive cell lines, None) , ( protein: Epstein-Barr virus nuclear antigen 2, None) , ( protein: EBNA-2, None) , ( protein: latent membrane protein gene promoter-binding proteins, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: EBNA-2 -positive cell lines, None) , ( protein: Epstein-Barr virus nuclear antigen 2, None) , ( protein: EBNA-2, None) , ( protein: latent membrane protein gene promoter-binding proteins, None) , ( protein: EBNA-2, None) " }

[]

{ "id": "947", "sentence": "The Epstein-Barr virus ( EBV ) nuclear antigen 2 ( EBNA-2 ) protein is essential for the immortalization of human primary B cells by EBV .", "label": " ( protein: Epstein-Barr virus ( EBV ) nuclear antigen 2, None) , ( cell type: human primary B cells, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Epstein-Barr virus ( EBV ) nuclear antigen 2, None) , ( cell type: human primary B cells, None) , ( protein: EBNA-2, None) " }

[]

{ "id": "948", "sentence": "EBNA-2 trans-activates cellular and viral genes like CD23 , c-fgr , latent membrane protein 1 ( LMP1 ) and terminal protein 1 ( TP1 ).", "label": " ( protein: latent membrane protein 1, None) , ( protein: terminal protein 1, None) , ( protein: TP1, None) , ( DNA: c-fgr, None) , ( DNA: CD23, None) , ( protein: LMP1, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: latent membrane protein 1, None) , ( protein: terminal protein 1, None) , ( protein: TP1, None) , ( DNA: c-fgr, None) , ( DNA: CD23, None) , ( protein: LMP1, None) , ( protein: EBNA-2, None) " }

[]

{ "id": "949", "sentence": "Trans-activation of the TP1 promoter and of the BamHI C promoter has already been investigated in detail and appears to be mediated via protein-protein interactions and not by direct binding of EBNA-2 type A (of EBV type 1 ) to the DNA.", "label": " ( DNA: BamHI C promoter, None) , ( protein: EBNA-2 type A, None) , ( DNA: TP1 promoter, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: BamHI C promoter, None) , ( protein: EBNA-2 type A, None) , ( DNA: TP1 promoter, None) , ( protein: EBNA-2, None) " }

[]

{ "id": "950", "sentence": "EBNA-2 is able to trans-activate the expression of the LMP gene in several cell lines.", "label": " ( protein: EBNA-2, None) , ( DNA: LMP gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: EBNA-2, None) , ( DNA: LMP gene, None) " }

[]

{ "id": "951", "sentence": "Various reports have delineated the cis-acting elements of the LMP promoter through which EBNA-2 mediates trans-activation .", "label": " ( DNA: LMP promoter, None) , ( protein: EBNA-2, None) , ( DNA: cis-acting elements, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LMP promoter, None) , ( protein: EBNA-2, None) , ( DNA: cis-acting elements, None) " }

[]

{ "id": "952", "sentence": "To determine whether EBNA-2 also trans-activates the LMP promoter by protein-protein interactions , we performed a series of gel retardation assays and competition experiments with LMP promoter fragments of different sizes.", "label": " ( DNA: LMP promoter, None) , ( DNA: LMP promoter fragments, None) , ( DNA: LMP promoter, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LMP promoter, None) , ( DNA: LMP promoter fragments, None) , ( DNA: LMP promoter, None) , ( protein: EBNA-2, None) " }

[]

{ "id": "953", "sentence": "We determined that the protein-binding region on the LMP promoter was within a 42 bp fragment encompassing nucleotides -135 to -176 relative to the LMP transcriptional start site .", "label": " ( DNA: protein-binding region, None) , ( DNA: LMP transcriptional start site, None) , ( DNA: LMP promoter, None) , ( DNA: nucleotides -135 to -176, None) , ( DNA: 42 bp fragment, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: protein-binding region, None) , ( DNA: LMP transcriptional start site, None) , ( DNA: LMP promoter, None) , ( DNA: nucleotides -135 to -176, None) , ( DNA: 42 bp fragment, None) " }

[]

{ "id": "954", "sentence": "None of the DNA fragments investigated indicated interaction of EBNA-2 with the DNA via protein-protein interactions .", "label": " ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: EBNA-2, None) " }

[]

{ "id": "955", "sentence": "No significant differences between EBNA-2 -positive and EBNA-2 -negative nuclear extracts could be seen in the gel retardation assay under conditions that clearly showed binding of EBNA-2A to the TP1 promoter .", "label": " ( protein: EBNA-2, None) , ( protein: EBNA-2A, None) , ( DNA: TP1 promoter, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: EBNA-2, None) , ( protein: EBNA-2A, None) , ( DNA: TP1 promoter, None) , ( protein: EBNA-2, None) " }

[]

{ "id": "956", "sentence": "However, analysis of sucrose gradient fractions in the gel retardation assay provided evidence that the LMP promoter -binding proteins form a complex of higher M(r) in EBNA-2 -positive cell extracts .", "label": " ( DNA: LMP promoter, None) , ( cell type: EBNA-2 -positive cell, None) , ( protein: LMP promoter -binding proteins, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LMP promoter, None) , ( cell type: EBNA-2 -positive cell, None) , ( protein: LMP promoter -binding proteins, None) , ( protein: EBNA-2, None) " }

[]

{ "id": "957", "sentence": "These complexes were destroyed by detergent.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "958", "sentence": "We deduce from these results that EBNA-2 -positive cells might indeed contain specific complexes bound to the LMP promoter which are, however, too labile to be detected in a standard gel retardation assay .", "label": " ( cell line: EBNA-2 -positive cells, None) , ( protein: specific complexes, None) , ( DNA: LMP promoter, None) , ( protein: EBNA-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: EBNA-2 -positive cells, None) , ( protein: specific complexes, None) , ( DNA: LMP promoter, None) , ( protein: EBNA-2, None) " }

[]

{ "id": "959", "sentence": "Simultaneous activation of Ig and Oct-2 synthesis and reduction of surface MHC class II expression by IL-6 .", "label": " ( protein: IL-6, None) , ( protein: Ig, None) , ( protein: MHC class II, None) , ( protein: Oct-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-6, None) , ( protein: Ig, None) , ( protein: MHC class II, None) , ( protein: Oct-2, None) " }

[]

{ "id": "960", "sentence": "Terminal differentiation of B cells to plasma cells in vivo is characterized by secretion of Ig and extinction of MHC class II expression on the cell surface.", "label": " ( protein: MHC class II, None) , ( cell type: B cells, None) , ( cell type: plasma cells, None) , ( protein: Ig, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MHC class II, None) , ( cell type: B cells, None) , ( cell type: plasma cells, None) , ( protein: Ig, None) " }

[]

{ "id": "961", "sentence": "We show that IL-6 signaling leads to marked increases in the synthesis and secretion of Ig in clonal human B cell lines and newly isolated polyclonal B lymphocytes in vitro.", "label": " ( cell type: isolated polyclonal B lymphocytes, None) , ( protein: Ig, None) , ( protein: IL-6, None) , ( cell line: clonal human B cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: isolated polyclonal B lymphocytes, None) , ( protein: Ig, None) , ( protein: IL-6, None) , ( cell line: clonal human B cell lines, None) " }

[]

{ "id": "962", "sentence": "The IL-6-induced cells resemble plasma cells in ultrastructure and in reduced expression of surface MHC class II .", "label": " ( cell line: IL-6-induced cells, None) , ( protein: surface MHC class II, None) , ( cell type: plasma cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: IL-6-induced cells, None) , ( protein: surface MHC class II, None) , ( cell type: plasma cells, None) " }

[]

{ "id": "963", "sentence": "Enhanced Ig synthesis is a result of coordinated transcriptional activation of Ig genes without promoter or isotype specificity, and differential accumulation of the mRNA encoding the secreted form of Ig heavy chain .", "label": " ( protein: Ig, None) , ( RNA: mRNA, None) , ( DNA: Ig genes, None) , ( protein: Ig heavy chain, None) , ( protein: Ig, None) , ( protein: Ig, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Ig, None) , ( RNA: mRNA, None) , ( DNA: Ig genes, None) , ( protein: Ig heavy chain, None) , ( protein: Ig, None) , ( protein: Ig, None) " }

[]

{ "id": "964", "sentence": "It is saturable and subject to negative control when IL-6 stimulation is prolonged.", "label": " ( protein: IL-6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-6, None) " }

[]

{ "id": "965", "sentence": "Coordinate with temporal changes in Ig synthesis , the DNA-binding activity and the synthesis of the B cell-enriched transcription factor Oct-2 are regulated.", "label": " ( protein: Ig, None) , ( protein: Oct-2, None) , ( protein: B cell-enriched transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Ig, None) , ( protein: Oct-2, None) , ( protein: B cell-enriched transcription factor, None) " }

[]

{ "id": "966", "sentence": "Thus, differentiation of B cells with IL-6 in vitro recapitulates the hallmarks of terminal B differentiation in vivo; Oct-2 may have a role in this process.", "label": " ( protein: IL-6, None) , ( cell type: B cells, None) , ( protein: Oct-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-6, None) , ( cell type: B cells, None) , ( protein: Oct-2, None) " }

[]

{ "id": "967", "sentence": "T-cell functional regions of the human IL-3 proximal promoter .", "label": " ( DNA: human IL-3 proximal promoter, None) , ( DNA: T-cell functional regions, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: human IL-3 proximal promoter, None) , ( DNA: T-cell functional regions, None) " }

[]

{ "id": "968", "sentence": "The human interleukin-3 ( IL-3 ) gene is expressed almost exclusively in activated T cells .", "label": " ( DNA: human interleukin-3 ( IL-3 ) gene, None) , ( protein: IL-3, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: human interleukin-3 ( IL-3 ) gene, None) , ( protein: IL-3, None) , ( cell type: T cells, None) " }

[]

{ "id": "969", "sentence": "Its expression is regulated at both the transcriptional and post-transcriptional level.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "970", "sentence": "We have previously shown that treatment of Jurkat T cells with phytohemaglutinin ( PHA ) and the phorbol ester , PMA , activated transcription initiation from the IL-3 gene .", "label": " ( protein: PHA, None) , ( protein: phytohemaglutinin, None) , ( cell line: Jurkat T cells, None) , ( DNA: IL-3 gene, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PHA, None) , ( protein: phytohemaglutinin, None) , ( cell line: Jurkat T cells, None) , ( DNA: IL-3 gene, None) , ( cell type: T cells, None) " }

[]

{ "id": "971", "sentence": "To define the regions of the gene required for transcription activation, we generated a series of reporter constructs containing different regions of the IL-3 gene 5' and 3' flanking sequences .", "label": " ( DNA: IL-3 gene 5#$%# and 3#$%# flanking sequences, None) , ( DNA: IL-3 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IL-3 gene 5#$%# and 3#$%# flanking sequences, None) , ( DNA: IL-3 gene, None) " }

[]

{ "id": "972", "sentence": "Both positive and negative regulatory elements were identified in the proximal 5' flanking region of the IL-3 gene .", "label": " ( DNA: proximal 5#$%# flanking region, None) , ( DNA: IL-3 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: proximal 5#$%# flanking region, None) , ( DNA: IL-3 gene, None) " }

[]

{ "id": "973", "sentence": "The promoter region between -173 and -60 contained the strongest activating elements .", "label": " ( DNA: promoter region, None) , ( DNA: activating elements, None) , ( DNA: -173 and -60, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: promoter region, None) , ( DNA: activating elements, None) , ( DNA: -173 and -60, None) " }

[]

{ "id": "974", "sentence": "The transcription factor AP-1 could bind to this positive activator region of the promoter.", "label": " ( protein: AP-1, None) , ( protein: transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( protein: transcription factor, None) " }

[]

{ "id": "975", "sentence": "We also examined the function of the IL-3 CK-1/CK-2 elements that are present in many cytokine genes and found that they acted as a repressor of basal level expression when cloned upstream of a heterologous promoter but were also inducible by PMA /PHA .", "label": " ( protein: /PHA, None) , ( DNA: IL-3 CK-1/CK-2 elements, None) , ( DNA: cytokine genes, None) , ( DNA: heterologous promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: /PHA, None) , ( DNA: IL-3 CK-1/CK-2 elements, None) , ( DNA: cytokine genes, None) , ( DNA: heterologous promoter, None) " }

[]

{ "id": "976", "sentence": "Expression of the Runt domain -encoding PEBP2 alpha genes in T cells during thymic development .", "label": " ( cell type: T cells, None) , ( DNA: Runt domain -encoding PEBP2 alpha genes, None) , ( protein: Runt domain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( DNA: Runt domain -encoding PEBP2 alpha genes, None) , ( protein: Runt domain, None) " }

[]

{ "id": "977", "sentence": "The PEBP2 alpha A and PEBP2 alpha B genes encode the DNA-binding subunit of a murine transcription factor , PEBP2 , which is implicated as a T-cell-specific transcriptional regulator .", "label": " ( protein: T-cell-specific transcriptional regulator, None) , ( protein: DNA-binding subunit, None) , ( protein: PEBP2, None) , ( protein: murine transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: T-cell-specific transcriptional regulator, None) , ( protein: DNA-binding subunit, None) , ( protein: PEBP2, None) , ( protein: murine transcription factor, None) " }

[]

{ "id": "978", "sentence": "These two related genes share the evolutionarily conserved region encoding the Runt domain .", "label": " ( protein: Runt domain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Runt domain, None) " }

[]

{ "id": "979", "sentence": "PEBP2 alpha B is the murine counterpart of human AML1 , which is located at the breakpoints of the 8;21 and 3;21 chromosome translocations associated with acute myeloid leukemia .", "label": " ( protein: murine counterpart, None) , ( protein: PEBP2, None) , ( protein: human AML1, None) , ( protein: PEBP2 alpha B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: murine counterpart, None) , ( protein: PEBP2, None) , ( protein: human AML1, None) , ( protein: PEBP2 alpha B, None) " }

[]

{ "id": "980", "sentence": "Northern (RNA) blots of various adult mouse tissues revealed that the levels of expression of both genes were most prominent in the thymus .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "981", "sentence": "Furthermore, transcripts of PEBP2 alpha A and mouse AML1/ PEBP2 alpha B were detected in T lymphocytes in the thymuses from day 16 embryos and newborns , as well as 4-week-old adult mice , by in situ hybridization .", "label": " ( protein: mouse AML1/ PEBP2 alpha B, None) , ( protein: PEBP2, None) , ( protein: PEBP2, None) , ( cell type: T lymphocytes, None) , ( protein: PEBP2 alpha A, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: mouse AML1/ PEBP2 alpha B, None) , ( protein: PEBP2, None) , ( protein: PEBP2, None) , ( cell type: T lymphocytes, None) , ( protein: PEBP2 alpha A, None) " }

[]

{ "id": "982", "sentence": "The expression of the genes persisted in peripheral lymph nodes of adult mice .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "983", "sentence": "The transcripts were detected in all the CD4- CD8- , CD4+ CD8+ , CD4+ CD8- , and CD4- CD8+ cell populations .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "984", "sentence": "The results indicated that both genes are expressed in T cells throughout their development, supporting the notion that PEBP2 is a T-cell-specific transcription factor .", "label": " ( cell type: T cells, None) , ( protein: T-cell-specific transcription factor, None) , ( protein: PEBP2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: T-cell-specific transcription factor, None) , ( protein: PEBP2, None) " }

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{ "id": "985", "sentence": "Transcripts of mouse AML1/ PEBP2 alpha B were also detected in day 12 fetal hematopoietic liver and in the bone marrow cells of newborn mice .", "label": " ( cell type: bone marrow cells, None) , ( protein: PEBP2, None) , ( protein: mouse AML1/ PEBP2 alpha B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: bone marrow cells, None) , ( protein: PEBP2, None) , ( protein: mouse AML1/ PEBP2 alpha B, None) " }

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{ "id": "986", "sentence": "The implication of mouse AML1/ PEBP2 alpha B expression in hematopoietic cells other than those of T-cell lineage is discussed in relation to myeloid leukemogenesis .", "label": " ( protein: PEBP2, None) , ( cell type: hematopoietic cells, None) , ( cell type: T-cell lineage, None) , ( protein: AML1/ PEBP2 alpha B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PEBP2, None) , ( cell type: hematopoietic cells, None) , ( cell type: T-cell lineage, None) , ( protein: AML1/ PEBP2 alpha B, None) " }

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{ "id": "987", "sentence": "Effects of glucocorticoids on transcription factor activation in human peripheral blood mononuclear cells .", "label": " ( cell type: human peripheral blood mononuclear cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human peripheral blood mononuclear cells, None) " }

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{ "id": "988", "sentence": "Glucocorticoids have an inhibitory effect on inflammatory and immune responses , and this may be through the modulation of transcription factor binding to DNA.", "label": " ( protein: transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor, None) " }

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{ "id": "989", "sentence": "The interaction of the transcription factors , activator protein-1 ( AP-1 ), nuclear factor kappa B ( NF kappa B ), and cAMP-responsive element binding protein ( CREB ) with DNA and glucocorticoid receptors ( GR ) was analyzed in human peripheral blood mononuclear cells by gel mobility shift assays .", "label": " ( protein: cAMP-responsive element binding protein, None) , ( protein: transcription factors, None) , ( protein: nuclear factor kappa B, None) , ( protein: glucocorticoid receptors, None) , ( cell type: human peripheral blood mononuclear cells, None) , ( protein: NF kappa B, None) , ( protein: AP-1, None) , ( protein: CREB, None) , ( protein: activator protein-1, None) , ( protein: GR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cAMP-responsive element binding protein, None) , ( protein: transcription factors, None) , ( protein: nuclear factor kappa B, None) , ( protein: glucocorticoid receptors, None) , ( cell type: human peripheral blood mononuclear cells, None) , ( protein: NF kappa B, None) , ( protein: AP-1, None) , ( protein: CREB, None) , ( protein: activator protein-1, None) , ( protein: GR, None) " }

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{ "id": "990", "sentence": "TNF-alpha , IL-1 beta and phorbol myristate acetate (PMA) treatment increased AP-1 and NF kappa B DNA binding by up to 200% but decreased CREB binding (38%) over a 60-min time course.", "label": " ( protein: CREB, None) , ( protein: AP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CREB, None) , ( protein: AP-1, None) " }

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{ "id": "991", "sentence": "Dexamethasone produced a rapid and sustained increase in glucocorticoid response element binding and a concomitant 40-50% decrease in AP-1 , NF kappa B , and CREB DNA binding that was blocked by combined dexamethasone and cytokine or PMA treatment .", "label": " ( protein: cytokine, None) , ( DNA: glucocorticoid response element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine, None) , ( DNA: glucocorticoid response element, None) " }

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{ "id": "992", "sentence": "These latter effects were due to increases in the nuclear localization of GR , not to reduced amounts of the other transcription factors .", "label": " ( protein: GR, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GR, None) , ( protein: transcription factors, None) " }

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{ "id": "993", "sentence": "This suggests that in these cells GR within the nucleus interacts with cytokine -stimulated transcription factors by the process of cross coupling.", "label": " ( protein: cytokine -stimulated transcription factors, None) , ( protein: cytokine, None) , ( protein: nucleus, None) , ( protein: GR, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine -stimulated transcription factors, None) , ( protein: cytokine, None) , ( protein: nucleus, None) , ( protein: GR, None) , ( protein: transcription factors, None) " }

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{ "id": "994", "sentence": "This may be an important molecular site of steroid action.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "995", "sentence": "Differential induction of the NF-AT complex during restimulation and the induction of T-cell anergy .", "label": " ( protein: NF-AT complex, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT complex, None) " }

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{ "id": "996", "sentence": "Stimulation of human CD4+ T-cell clones through the T-cell receptor ( TcR ) by high doses of specific peptide results in the induction of a long-lived state of nonresponsiveness that has been called anergy .", "label": " ( cell line: human CD4+ T-cell clones, None) , ( protein: T-cell receptor, None) , ( protein: TcR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: human CD4+ T-cell clones, None) , ( protein: T-cell receptor, None) , ( protein: TcR, None) " }

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{ "id": "997", "sentence": "During the induction of anergy , T cells are phenotypically similar to cells responding to an immunogenic stimulus .", "label": " ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) " }

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{ "id": "998", "sentence": "The amount of TcR at the cell surface is downmodulated, whereas the CD2 and CD25 receptors are increased.", "label": " ( protein: TcR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TcR, None) " }

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{ "id": "999", "sentence": "When restimulated, however, anergic T cells fail to up-regulate transcription of the IL-2 gene and in consequence do not produce IL-2 .", "label": " ( protein: IL-2, None) , ( cell type: anergic T cells, None) , ( DNA: IL-2 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( cell type: anergic T cells, None) , ( DNA: IL-2 gene, None) " }