Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "700", "sentence": "However, it was not detected in lymphoid cells MOLT4 ( T cell ) and BALL1 ( B cell ), nor in K562 erythroblasts .", "label": " ( cell type: lymphoid cells, None) , ( cell line: BALL1, None) , ( cell line: MOLT4, None) , ( cell type: T cell, None) , ( cell line: K562 erythroblasts, None) , ( cell type: B cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphoid cells, None) , ( cell line: BALL1, None) , ( cell line: MOLT4, None) , ( cell type: T cell, None) , ( cell line: K562 erythroblasts, None) , ( cell type: B cell, None) " }

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{ "id": "701", "sentence": "Furthermore, a specific induction of AhR during monocytic differentiation was investigated in HL60 and HEL cells .", "label": " ( cell line: HL60, None) , ( protein: AhR, None) , ( cell line: HEL cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL60, None) , ( protein: AhR, None) , ( cell line: HEL cells, None) " }

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{ "id": "702", "sentence": "HL60 cells were induced to differentiate toward monocytes-macrophages by incubation with phorbol ester, showing a 5- to 2-fold increase of AhR mRNA .", "label": " ( protein: AhR, None) , ( RNA: AhR mRNA, None) , ( cell line: HL60 cells, None) , ( cell type: monocytes-macrophages, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AhR, None) , ( RNA: AhR mRNA, None) , ( cell line: HL60 cells, None) , ( cell type: monocytes-macrophages, None) " }

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{ "id": "703", "sentence": "The incubation with transforming growth factor beta 1 and 1 alpha,25-dihydroxyvitamin D3 resulted in a 5- to 7-fold increase of AhR mRNA .", "label": " ( protein: AhR, None) , ( protein: transforming growth factor beta 1, None) , ( RNA: AhR mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AhR, None) , ( protein: transforming growth factor beta 1, None) , ( RNA: AhR mRNA, None) " }

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{ "id": "704", "sentence": "The HEL cells also exhibited a similar elevation of AhR mRNA level , when they had differentiated toward monocyte-macrophage cells by these combined inducers, but little change in the mRNA level was observed when the cells were induced to differentiate into other cell types.", "label": " ( cell type: monocyte-macrophage cells, None) , ( cell line: HEL cells, None) , ( protein: AhR, None) , ( RNA: AhR mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocyte-macrophage cells, None) , ( cell line: HEL cells, None) , ( protein: AhR, None) , ( RNA: AhR mRNA, None) " }

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{ "id": "705", "sentence": "Treatment of the differentiated HL60 cells with 3-methylcholanthrene , a ligand of AhR , induced the expression of the P450IA1 gene.", "label": " ( protein: AhR, None) , ( cell line: differentiated HL60 cells, None) , ( protein: P450IA1, None) , ( cell line: HL60, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AhR, None) , ( cell line: differentiated HL60 cells, None) , ( protein: P450IA1, None) , ( cell line: HL60, None) " }

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{ "id": "706", "sentence": "These results indicated that expression of AhR mRNA was significantly induced during monocytic differentiation and that the differentiated cells were responsive to xenobiotics .", "label": " ( RNA: AhR mRNA, None) , ( protein: AhR, None) , ( cell type: differentiated cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: AhR mRNA, None) , ( protein: AhR, None) , ( cell type: differentiated cells, None) " }

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{ "id": "707", "sentence": "Our results suggest that AhR may play an important role in the function of monocytes and also in the eventual activation of environmental carcinogens .", "label": " ( cell type: monocytes, None) , ( protein: AhR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytes, None) , ( protein: AhR, None) " }

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{ "id": "708", "sentence": "Neutrophils and monocytes express high levels of PU.1 ( Spi-1 ) but not Spi-B .", "label": " ( protein: Spi-B, None) , ( protein: PU.1, None) , ( cell type: Neutrophils, None) , ( cell type: monocytes, None) , ( protein: Spi-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Spi-B, None) , ( protein: PU.1, None) , ( cell type: Neutrophils, None) , ( cell type: monocytes, None) , ( protein: Spi-1, None) " }

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{ "id": "709", "sentence": "PU.1 (the Spi-1 oncogene ) and Spi-B are closely related members of the ets transcription factor family , sharing similar DNA binding specificities mediated by similar DNA binding domains .", "label": " ( protein: DNA binding domains, None) , ( protein: PU.1, None) , ( protein: ets transcription factor family, None) , ( protein: Spi-B, None) , ( DNA: Spi-1 oncogene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNA binding domains, None) , ( protein: PU.1, None) , ( protein: ets transcription factor family, None) , ( protein: Spi-B, None) , ( DNA: Spi-1 oncogene, None) " }

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{ "id": "710", "sentence": "PU.1 and Spi-B have been previously described as being predominantly expressed coordinately in macrophages and B cells , but their expression in early hematopoietic stages and during the course of myeloid differentiation to monocytes and macrophages or to neutrophils has not been extensively investigated.", "label": " ( cell type: macrophages, None) , ( cell type: macrophages, None) , ( protein: PU.1, None) , ( cell type: monocytes, None) , ( cell type: B cells, None) , ( cell type: neutrophils, None) , ( protein: Spi-B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: macrophages, None) , ( cell type: macrophages, None) , ( protein: PU.1, None) , ( cell type: monocytes, None) , ( cell type: B cells, None) , ( cell type: neutrophils, None) , ( protein: Spi-B, None) " }

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{ "id": "711", "sentence": "Here, we report that PU.1 mRNA is upregulated during myeloid differentiation of human purified CD34+ cells and murine multipotential FDCP-mix A4 cells , suggesting that PU.1 is upregulated as an early event during differentiation of multipotential progenitor cells .", "label": " ( RNA: PU.1 mRNA, None) , ( protein: PU.1, None) , ( cell line: human purified CD34+ cells, None) , ( cell type: multipotential progenitor cells, None) , ( protein: PU.1, None) , ( cell line: murine multipotential FDCP-mix A4 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: PU.1 mRNA, None) , ( protein: PU.1, None) , ( cell line: human purified CD34+ cells, None) , ( cell type: multipotential progenitor cells, None) , ( protein: PU.1, None) , ( cell line: murine multipotential FDCP-mix A4 cells, None) " }

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{ "id": "712", "sentence": "PU.1 expression is maintained at stable levels during differentiation of myeloid cell lines U937 and HL-60 to monocytic and neutrophilic cells .", "label": " ( protein: PU.1, None) , ( cell line: myeloid cell lines, None) , ( cell line: HL-60, None) , ( cell line: U937, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PU.1, None) , ( cell line: myeloid cell lines, None) , ( cell line: HL-60, None) , ( cell line: U937, None) " }

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{ "id": "713", "sentence": "PU.1 is expressed at highest levels in mature human monocytes and human peripheral blood neutrophils .", "label": " ( cell type: human peripheral blood neutrophils, None) , ( cell type: mature human monocytes, None) , ( cell type: monocytes, None) , ( protein: PU.1, None) , ( cell type: neutrophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human peripheral blood neutrophils, None) , ( cell type: mature human monocytes, None) , ( cell type: monocytes, None) , ( protein: PU.1, None) , ( cell type: neutrophils, None) " }

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{ "id": "714", "sentence": "In contrast to PU.1 , significant levels of Spi-B mRNA and protein are found only in some B-cell lines and spleen but are not found in myeloid cell lines , neutrophils , or macrophages .", "label": " ( cell type: neutrophils, None) , ( protein: PU.1, None) , ( RNA: Spi-B mRNA, None) , ( cell type: macrophages, None) , ( cell line: B-cell lines, None) , ( protein: Spi-B, None) , ( cell line: myeloid cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: neutrophils, None) , ( protein: PU.1, None) , ( RNA: Spi-B mRNA, None) , ( cell type: macrophages, None) , ( cell line: B-cell lines, None) , ( protein: Spi-B, None) , ( cell line: myeloid cell lines, None) " }

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{ "id": "715", "sentence": "In vitro translated Spi-B protein can bind to PU.1 binding sites in myeloid promoters and transactivate these promoters in nonmyeloid cells .", "label": " ( cell type: nonmyeloid cells, None) , ( protein: Spi-B, None) , ( protein: Spi-B protein, None) , ( DNA: PU.1 binding sites, None) , ( DNA: promoters, None) , ( protein: PU.1, None) , ( DNA: myeloid promoters, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: nonmyeloid cells, None) , ( protein: Spi-B, None) , ( protein: Spi-B protein, None) , ( DNA: PU.1 binding sites, None) , ( DNA: promoters, None) , ( protein: PU.1, None) , ( DNA: myeloid promoters, None) " }

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{ "id": "716", "sentence": "Therefore, although PU.1 and Spi-B may bind to similar DNA control elements and have redundancy of transactivation function in vitro, the lack of significant levels of Spi-B in myeloid cells makes it unlikely that Spi-B plays a significant role in myeloid lineage development and gene expression .", "label": " ( protein: PU.1, None) , ( protein: Spi-B, None) , ( protein: Spi-B, None) , ( protein: Spi-B, None) , ( cell type: myeloid cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PU.1, None) , ( protein: Spi-B, None) , ( protein: Spi-B, None) , ( protein: Spi-B, None) , ( cell type: myeloid cells, None) " }

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{ "id": "717", "sentence": "In contrast, PU.1 is expressed at high levels not only in monocytes and macrophages but also in neutrophils , indicating that PU.1 can activate gene expression in both major myeloid lineages .", "label": " ( protein: PU.1, None) , ( cell type: major myeloid lineages, None) , ( cell type: neutrophils, None) , ( cell type: monocytes, None) , ( cell type: macrophages, None) , ( protein: PU.1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PU.1, None) , ( cell type: major myeloid lineages, None) , ( cell type: neutrophils, None) , ( cell type: monocytes, None) , ( cell type: macrophages, None) , ( protein: PU.1, None) " }

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{ "id": "718", "sentence": "Identification of a major positive regulatory element located 5' to the human zeta-globin gene .", "label": " ( DNA: human zeta-globin gene, None) , ( DNA: positive regulatory element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: human zeta-globin gene, None) , ( DNA: positive regulatory element, None) " }

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{ "id": "719", "sentence": "The function of the zeta-globin promoter was studied using a series of zeta-globin promoter deletion constructs to drive luciferase expression in transiently transfected human erythroleukemia cells .", "label": " ( DNA: zeta-globin promoter, None) , ( cell line: transiently transfected human erythroleukemia cells, None) , ( DNA: zeta-globin promoter, None) , ( protein: luciferase, None) , ( DNA: zeta-globin promoter deletion constructs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: zeta-globin promoter, None) , ( cell line: transiently transfected human erythroleukemia cells, None) , ( DNA: zeta-globin promoter, None) , ( protein: luciferase, None) , ( DNA: zeta-globin promoter deletion constructs, None) " }

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{ "id": "720", "sentence": "The promoters were used without enhancers , or with enhancers derived from the beta-globin locus control region and the alpha-globin HS-40 enhancer .", "label": " ( DNA: alpha-globin HS-40 enhancer, None) , ( DNA: enhancers, None) , ( DNA: beta-globin locus control region, None) , ( DNA: promoters, None) , ( DNA: enhancers, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: alpha-globin HS-40 enhancer, None) , ( DNA: enhancers, None) , ( DNA: beta-globin locus control region, None) , ( DNA: promoters, None) , ( DNA: enhancers, None) " }

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{ "id": "721", "sentence": "When transfected into K562 cells , which express zeta-globin , comparable amounts of activity were obtained from the -557 and -417 zeta- luciferase constructs and the alpha- luciferase constructs when no enhancers or the alpha-globin locus enhancers were used.", "label": " ( protein: luciferase, None) , ( DNA: enhancers, None) , ( DNA: alpha-globin locus enhancers, None) , ( DNA: alpha- luciferase constructs, None) , ( cell line: K562 cells, None) , ( DNA: -557 and -417 zeta- luciferase constructs, None) , ( DNA: enhancers, None) , ( protein: luciferase, None) , ( protein: zeta-globin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: luciferase, None) , ( DNA: enhancers, None) , ( DNA: alpha-globin locus enhancers, None) , ( DNA: alpha- luciferase constructs, None) , ( cell line: K562 cells, None) , ( DNA: -557 and -417 zeta- luciferase constructs, None) , ( DNA: enhancers, None) , ( protein: luciferase, None) , ( protein: zeta-globin, None) " }

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{ "id": "722", "sentence": "When the constructs were transfected into OCIM1 cells , which do not express zeta-globin , the zeta-globin promoters were at best 20% as active as the alpha-globin promoters .", "label": " ( cell line: OCIM1 cells, None) , ( DNA: promoters, None) , ( DNA: zeta-globin promoters, None) , ( protein: zeta-globin, None) , ( DNA: alpha-globin promoters, None) , ( protein: zeta-globin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: OCIM1 cells, None) , ( DNA: promoters, None) , ( DNA: zeta-globin promoters, None) , ( protein: zeta-globin, None) , ( DNA: alpha-globin promoters, None) , ( protein: zeta-globin, None) " }

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{ "id": "723", "sentence": "When sequences from -417 to -207 5' to the zeta-globin mRNA cap site were deleted, up to 95% of the zeta-globin promoter activity was lost in K562 cells .", "label": " ( RNA: zeta-globin mRNA cap site, None) , ( cell line: K562 cells, None) , ( DNA: zeta-globin promoter, None) , ( DNA: sequences from -417 to -207 5#$%#, None) , ( protein: zeta-globin, None) , ( RNA: zeta-globin mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: zeta-globin mRNA cap site, None) , ( cell line: K562 cells, None) , ( DNA: zeta-globin promoter, None) , ( DNA: sequences from -417 to -207 5#$%#, None) , ( protein: zeta-globin, None) , ( RNA: zeta-globin mRNA, None) " }

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{ "id": "724", "sentence": "Reinsertion of these sequences into zeta- luciferase constructs missing the -417 to -207 region showed that the sequences lack classical enhancer activity .", "label": " ( protein: luciferase, None) , ( DNA: zeta- luciferase constructs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: luciferase, None) , ( DNA: zeta- luciferase constructs, None) " }

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{ "id": "725", "sentence": "Point mutation of a GATA-1 site at -230 reduced promoter activity by 37%.", "label": " ( DNA: GATA-1 site, None) , ( protein: GATA-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: GATA-1 site, None) , ( protein: GATA-1, None) " }

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{ "id": "726", "sentence": "Point mutation of a CCACC site at -240 had no effect.", "label": " ( DNA: CCACC site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: CCACC site, None) " }

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{ "id": "727", "sentence": "Electrophoretic mobility shift assays indicated that the -230 GATA-1 site has a relatively low affinity for GATA-1 .", "label": " ( DNA: -230 GATA-1 site, None) , ( protein: GATA-1, None) , ( protein: GATA-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: -230 GATA-1 site, None) , ( protein: GATA-1, None) , ( protein: GATA-1, None) " }

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{ "id": "728", "sentence": "These experiments show the presence of a strong positive-acting element , located between -417 and -207 bp 5' to the zeta-globin mRNA cap site , is necessary for high-level promoter activity in K562 cells .", "label": " ( DNA: positive-acting element, None) , ( DNA: -417 and -207 bp 5#$%#, None) , ( RNA: zeta-globin mRNA, None) , ( DNA: zeta-globin mRNA cap site, None) , ( protein: zeta-globin, None) , ( cell line: K562 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: positive-acting element, None) , ( DNA: -417 and -207 bp 5#$%#, None) , ( RNA: zeta-globin mRNA, None) , ( DNA: zeta-globin mRNA cap site, None) , ( protein: zeta-globin, None) , ( cell line: K562 cells, None) " }

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{ "id": "729", "sentence": "This element requires GATA-1 and additional unknown factors for maximal activity .", "label": " ( protein: GATA-1, None) , ( protein: additional unknown factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA-1, None) , ( protein: additional unknown factors, None) " }

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{ "id": "730", "sentence": "Analysis of the role of protein kinase C -alpha , -epsilon , and -zeta in T cell activation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "731", "sentence": "T cells express multiple isotypes of protein kinase C ( PKC ) and although it is well accepted that PKCs have an important role in T cell activation , little is known about the function of individual PKC isotypes .", "label": " ( protein: protein kinase C, None) , ( protein: PKC isotypes, None) , ( protein: PKCs, None) , ( cell type: T cells, None) , ( protein: PKC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: protein kinase C, None) , ( protein: PKC isotypes, None) , ( protein: PKCs, None) , ( cell type: T cells, None) , ( protein: PKC, None) " }

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{ "id": "732", "sentence": "To address this issue, mutationally active PKC -alpha , -epsilon , or -zeta have been transfected into T cells and the consequences for T cell activation determined.", "label": " ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) " }

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{ "id": "733", "sentence": "p21ras plays an essential role in T cell activation .", "label": " ( protein: p21ras, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p21ras, None) " }

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{ "id": "734", "sentence": "Accordingly, the effects of the constitutively active PKCs were compared to the effects of mutationally activated p21ras .", "label": " ( protein: constitutively active PKCs, None) , ( protein: p21ras, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: constitutively active PKCs, None) , ( protein: p21ras, None) " }

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{ "id": "735", "sentence": "The data indicate that PKC-epsilon and, to a lesser extent PKC-alpha but not -zeta , can regulate the transcription factors AP-1 and nuclear factor of activated T cells ( NF-AT-1 ).", "label": " ( protein: PKC-alpha, None) , ( protein: AP-1, None) , ( protein: NF-AT-1, None) , ( protein: transcription factors, None) , ( protein: factor of activated T cells, None) , ( protein: PKC-epsilon, None) , ( protein: -zeta, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC-alpha, None) , ( protein: AP-1, None) , ( protein: NF-AT-1, None) , ( protein: transcription factors, None) , ( protein: factor of activated T cells, None) , ( protein: PKC-epsilon, None) , ( protein: -zeta, None) , ( cell type: T cells, None) " }

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{ "id": "736", "sentence": "The ability of PKC-epsilon to induce transactivation of NF-AT-1 and AP-1 was similar to the stimulatory effect of a constitutively activated p21ras .", "label": " ( protein: PKC-epsilon, None) , ( protein: p21ras, None) , ( protein: constitutively activated p21ras, None) , ( protein: NF-AT-1, None) , ( protein: AP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC-epsilon, None) , ( protein: p21ras, None) , ( protein: constitutively activated p21ras, None) , ( protein: NF-AT-1, None) , ( protein: AP-1, None) " }

[]

{ "id": "737", "sentence": "PKC-epsilon , but not PKC-alpha nor activated p21ras , was able to induce NF-KB activity .", "label": " ( protein: NF-KB, None) , ( protein: PKC-alpha, None) , ( protein: PKC-epsilon, None) , ( protein: p21ras, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-KB, None) , ( protein: PKC-alpha, None) , ( protein: PKC-epsilon, None) , ( protein: p21ras, None) " }

[]

{ "id": "738", "sentence": "Phorbol esters induce expression of CD69 whereas none of the activated PKC isotypes tested were able to have this effect.", "label": " ( protein: CD69, None) , ( protein: activated PKC isotypes, None) , ( protein: PKC isotypes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD69, None) , ( protein: activated PKC isotypes, None) , ( protein: PKC isotypes, None) " }

[]

{ "id": "739", "sentence": "Activated Src and p21ras were able to induce CD69 expression .", "label": " ( protein: CD69, None) , ( protein: Src, None) , ( protein: p21ras, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD69, None) , ( protein: Src, None) , ( protein: p21ras, None) " }

[]

{ "id": "740", "sentence": "These results indicate selective functions for different PKC isotypes in T cells .", "label": " ( protein: PKC isotypes, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC isotypes, None) , ( cell type: T cells, None) " }

[]

{ "id": "741", "sentence": "Moreover, the data comparing the effects of activated Ras and PKC mutants suggest that PKC-alpha , p21ras , and PKC-epsilon are not positioned linearly on a single signal transduction pathway .", "label": " ( protein: activated Ras, None) , ( protein: PKC-alpha, None) , ( protein: PKC-epsilon, None) , ( protein: p21ras, None) , ( protein: PKC mutants, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: activated Ras, None) , ( protein: PKC-alpha, None) , ( protein: PKC-epsilon, None) , ( protein: p21ras, None) , ( protein: PKC mutants, None) " }

[]

{ "id": "742", "sentence": "Differences in binding of glucocorticoid receptor to DNA in steroid-resistant asthma .", "label": " ( protein: glucocorticoid receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptor, None) " }

[]

{ "id": "743", "sentence": "Although glucocorticosteroids are a very effective treatment for asthma and other chronic inflammatory diseases , a small proportion of patients are resistant to their therapeutic effects .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "744", "sentence": "The molecular mechanism for this steroid resistance is unclear.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "745", "sentence": "Steroid resistance cannot be explained by pharmacokinetic mechanisms , by a defect in the binding of steroids to glucocorticoid receptors , nor by defective nuclear translocation of this receptor, thereby suggesting that the molecular abnormality lies distal to nuclear translocation .", "label": " ( protein: glucocorticoid receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptors, None) " }

[]

{ "id": "746", "sentence": "We examined the ability of nuclear translocated glucocorticoid receptors to bind to their DNA binding sites ( GRE ) using electrophoretic mobility shift assays in PBMC from patients with steroid-sensitive and steroid-resistant asthma .", "label": " ( protein: glucocorticoid receptors, None) , ( DNA: DNA binding sites, None) , ( DNA: GRE, None) , ( cell type: PBMC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptors, None) , ( DNA: DNA binding sites, None) , ( DNA: GRE, None) , ( cell type: PBMC, None) " }

[]

{ "id": "747", "sentence": "The binding of the glucocorticoid receptor to DNA in these patients was also studied using Scatchard analysis .", "label": " ( protein: glucocorticoid receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptor, None) " }

[]

{ "id": "748", "sentence": "Dexamethasone induced a significant rapid and sustained twofold increase in GRE binding in PBMCs from steroid-sensitive asthmatic patients and nonasthmatic individuals , but this was markedly reduced in steroid-resistant asthmatic patients .", "label": " ( cell type: PBMCs, None) , ( DNA: GRE, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PBMCs, None) , ( DNA: GRE, None) " }

[]

{ "id": "749", "sentence": "Scatchard analysis of glucocorticoid receptor - GRE binding showed no change in binding affinity but did show a reduced number of receptors available for DNA binding in the steroid-resistant patients .", "label": " ( protein: glucocorticoid receptor, None) , ( protein: receptors, None) , ( DNA: GRE, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptor, None) , ( protein: receptors, None) , ( DNA: GRE, None) " }

[]

{ "id": "750", "sentence": "These results suggest that the ability of the glucocorticoid receptor to bind to GRE is impaired in steroid-resistant patients because of a reduced number of receptors available for binding to DNA.", "label": " ( protein: receptors, None) , ( DNA: GRE, None) , ( protein: glucocorticoid receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: receptors, None) , ( DNA: GRE, None) , ( protein: glucocorticoid receptor, None) " }

[]

{ "id": "751", "sentence": "Interleukin-5 signaling in human eosinophils involves JAK2 tyrosine kinase and Stat1 alpha .", "label": " ( protein: Stat1 alpha, None) , ( protein: JAK2, None) , ( protein: Interleukin-5, None) , ( protein: JAK2 tyrosine kinase, None) , ( cell type: human eosinophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Stat1 alpha, None) , ( protein: JAK2, None) , ( protein: Interleukin-5, None) , ( protein: JAK2 tyrosine kinase, None) , ( cell type: human eosinophils, None) " }

[]

{ "id": "752", "sentence": "Signaling by a wide variety of cytokines , including interferons , interleukins , and growth factors , involves activation of JAK kinases and Stat ( Signal transducers and activators of transcription ) proteins .", "label": " ( protein: cytokines, None) , ( protein: Signal transducers and activators of transcription, None) , ( protein: growth factors, None) , ( protein: interleukins, None) , ( protein: JAK kinases, None) , ( protein: interferons, None) , ( protein: Stat, None) , ( protein: Stat ( Signal transducers and activators of transcription ) proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokines, None) , ( protein: Signal transducers and activators of transcription, None) , ( protein: growth factors, None) , ( protein: interleukins, None) , ( protein: JAK kinases, None) , ( protein: interferons, None) , ( protein: Stat, None) , ( protein: Stat ( Signal transducers and activators of transcription ) proteins, None) " }

[]

{ "id": "753", "sentence": "At present, not much is known about the molecular mechanisms by which interleukin-5 ( IL-5 ) exerts its diverse biologic effects .", "label": " ( protein: IL-5, None) , ( protein: interleukin-5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-5, None) , ( protein: interleukin-5, None) " }

[]

{ "id": "754", "sentence": "Human eosinophils are one of the most important target cells for IL-5 and were used here to study IL-5 signaling in a primary human cell .", "label": " ( protein: IL-5, None) , ( cell type: primary human cell, None) , ( cell type: Human eosinophils, None) , ( cell type: target cells, None) , ( protein: IL-5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-5, None) , ( cell type: primary human cell, None) , ( cell type: Human eosinophils, None) , ( cell type: target cells, None) , ( protein: IL-5, None) " }

[]

{ "id": "755", "sentence": "IL-5 induced rapid and transient tyrosine phosphorylation of JAK2 .", "label": " ( protein: JAK2, None) , ( protein: IL-5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: JAK2, None) , ( protein: IL-5, None) " }

[]

{ "id": "756", "sentence": "Moreover, IL-5 induced at least two DNA-binding complexes , using nuclear extracts from normal human eosinophils and the IL-6/interferon-gamma response element of the ICAM-1 promoter ( ICAM-1 pIRE ) in an electromobility shift assay .", "label": " ( DNA: ICAM-1 pIRE, None) , ( DNA: IL-6/interferon-gamma response element, None) , ( DNA: ICAM-1 promoter, None) , ( protein: IL-5, None) , ( cell type: human eosinophils, None) , ( protein: DNA-binding complexes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: ICAM-1 pIRE, None) , ( DNA: IL-6/interferon-gamma response element, None) , ( DNA: ICAM-1 promoter, None) , ( protein: IL-5, None) , ( cell type: human eosinophils, None) , ( protein: DNA-binding complexes, None) " }

[]

{ "id": "757", "sentence": "From supershift experiments it was concluded that one DNA-binding complex contained Stat1 alpha , probably as a homodimer.", "label": " ( protein: DNA-binding complex, None) , ( protein: Stat1 alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNA-binding complex, None) , ( protein: Stat1 alpha, None) " }

[]

{ "id": "758", "sentence": "Both DNA-binding complexes were inhibited by a phosphotyrosine antibody ( 4G10 ), suggesting that tyrosine phosphorylation is required for complex formation .", "label": " ( protein: DNA-binding complexes, None) , ( protein: phosphotyrosine antibody, None) , ( protein: 4G10, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNA-binding complexes, None) , ( protein: phosphotyrosine antibody, None) , ( protein: 4G10, None) " }

[]

{ "id": "759", "sentence": "IL-3 and granulocyte-macrophage colony-stimulating factor induced, similar to IL-5 , two DNA-binding complexes in human eosinophils , including Stat1 alpha .", "label": " ( protein: DNA-binding complexes, None) , ( protein: IL-3, None) , ( protein: Stat1 alpha, None) , ( protein: IL-5, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( cell type: human eosinophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNA-binding complexes, None) , ( protein: IL-3, None) , ( protein: Stat1 alpha, None) , ( protein: IL-5, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( cell type: human eosinophils, None) " }

[]

{ "id": "760", "sentence": "These data show for the first time that molecular mechanisms of IL-5 signaling in human eosinophils involve members of the JAK kinase family as well as members of the Stat family .", "label": " ( protein: JAK kinase family, None) , ( protein: IL-5, None) , ( cell type: human eosinophils, None) , ( protein: Stat family, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: JAK kinase family, None) , ( protein: IL-5, None) , ( cell type: human eosinophils, None) , ( protein: Stat family, None) " }

[]

{ "id": "761", "sentence": "Infection and replication of Tat- human immunodeficiency viruses : genetic analyses of LTR and tat mutations in primary and long-term human lymphoid cells .", "label": " ( DNA: LTR, None) , ( protein: tat mutations, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LTR, None) , ( protein: tat mutations, None) " }

[]

{ "id": "762", "sentence": "Tat is an essential regulatory protein for the replication of human immunodeficiency virus ( HIV ).", "label": " ( protein: regulatory protein, None) , ( protein: Tat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: regulatory protein, None) , ( protein: Tat, None) " }

[]

{ "id": "763", "sentence": "Mutations in the tat gene have been shown to block HIV replication in human T cells .", "label": " ( cell type: human T cells, None) , ( DNA: tat gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human T cells, None) , ( DNA: tat gene, None) " }

[]

{ "id": "764", "sentence": "Several studies have established that Tat releases an elongation block to the transcription of HIV long terminal repeat ( LTR ); however, it is not known whether this mechanism alone is sufficient to explain the block to HIV replication in human T cells when Tat is absent.", "label": " ( DNA: LTR, None) , ( protein: elongation block, None) , ( DNA: HIV long terminal repeat, None) , ( protein: Tat, None) , ( cell type: human T cells, None) , ( protein: Tat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LTR, None) , ( protein: elongation block, None) , ( DNA: HIV long terminal repeat, None) , ( protein: Tat, None) , ( cell type: human T cells, None) , ( protein: Tat, None) " }

[]

{ "id": "765", "sentence": "It is possible that Tat is also needed for other functions during HIV replication .", "label": " ( protein: Tat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tat, None) " }

[]

{ "id": "766", "sentence": "To test these hypotheses, we studied several tat mutants , including two stop codon mutants and one deletion mutant using replication-competent HIV-1 constructs carrying wild-type or mutant LTRs with modifications in the NF-kappa B and/or Sp1 binding sites .", "label": " ( protein: deletion mutant, None) , ( DNA: replication-competent HIV-1 constructs, None) , ( protein: stop codon mutants, None) , ( protein: tat mutants, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: deletion mutant, None) , ( DNA: replication-competent HIV-1 constructs, None) , ( protein: stop codon mutants, None) , ( protein: tat mutants, None) " }

[]

{ "id": "767", "sentence": "In this study, we show that Tat- HIV-1 with wild-type LTRs can replicate in HeLa cells , and the virus produced from HeLa cells can infect primary peripheral blood lymphocytes and macrophages .", "label": " ( cell type: macrophages, None) , ( cell line: HeLa cells, None) , ( DNA: wild-type LTRs, None) , ( cell type: peripheral blood lymphocytes, None) , ( cell line: HeLa cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: macrophages, None) , ( cell line: HeLa cells, None) , ( DNA: wild-type LTRs, None) , ( cell type: peripheral blood lymphocytes, None) , ( cell line: HeLa cells, None) " }

[]

{ "id": "768", "sentence": "It was found that the propagation of the Tat mutants containing wild-type LTRs was less efficient than that of the LTR-modified Tat mutants .", "label": " ( DNA: wild-type LTRs, None) , ( protein: Tat, None) , ( protein: Tat, None) , ( protein: LTR-modified Tat mutants, None) , ( protein: Tat mutants, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: wild-type LTRs, None) , ( protein: Tat, None) , ( protein: Tat, None) , ( protein: LTR-modified Tat mutants, None) , ( protein: Tat mutants, None) " }

[]

{ "id": "769", "sentence": "Large amounts of viral RNA and particles were synthesized in infections established using the tat mutants that contain modified LTRs .", "label": " ( protein: tat mutants, None) , ( DNA: modified LTRs, None) , ( RNA: viral RNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tat mutants, None) , ( DNA: modified LTRs, None) , ( RNA: viral RNA, None) " }

[]

{ "id": "770", "sentence": "However, this efficient propagation of the LTR-modified tat mutants was restricted to some lymphoid cell lines that have been transformed with other viruses .", "label": " ( protein: tat mutants, None) , ( cell line: lymphoid cell lines, None) , ( protein: LTR-modified tat mutants, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tat mutants, None) , ( cell line: lymphoid cell lines, None) , ( protein: LTR-modified tat mutants, None) " }

[]

{ "id": "771", "sentence": "Thus, despite its essential role for releasing an elongation block , Tat is not otherwise absolutely required for synthesis of full-length HIV transcripts and assembly of virus particles .", "label": " ( protein: Tat, None) , ( RNA: full-length HIV transcripts, None) , ( protein: elongation block, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tat, None) , ( RNA: full-length HIV transcripts, None) , ( protein: elongation block, None) " }

[]

{ "id": "772", "sentence": "Direct sequencing of the viral genomes and reinfection kinetics showed no evidence of wild-type reversion even after prolonged infection with the Tat -virus .", "label": " ( DNA: viral genomes, None) , ( protein: Tat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: viral genomes, None) , ( protein: Tat, None) " }

[]

{ "id": "773", "sentence": "The implications for in vivo HIV-1 replication and potential application of this system to the study of alternative Tat function are discussed.", "label": " ( protein: Tat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tat, None) " }

[]

{ "id": "774", "sentence": "Functional roles of the transcription factor Oct-2A and the high mobility group protein I/Y in HLA-DRA gene expression .", "label": " ( protein: I/Y, None) , ( protein: Oct-2A, None) , ( protein: transcription factor Oct-2A, None) , ( DNA: HLA-DRA gene, None) , ( protein: high mobility group protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I/Y, None) , ( protein: Oct-2A, None) , ( protein: transcription factor Oct-2A, None) , ( DNA: HLA-DRA gene, None) , ( protein: high mobility group protein, None) " }

[]

{ "id": "775", "sentence": "The class II major histocompatibility complex gene HLA-DRA is expressed in B cells , activated T lymphocytes , and in antigen-presenting cells .", "label": " ( DNA: class II major histocompatibility complex gene, None) , ( cell type: B cells, None) , ( cell type: antigen-presenting cells, None) , ( DNA: HLA-DRA, None) , ( protein: class II major histocompatibility complex, None) , ( cell type: T lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: class II major histocompatibility complex gene, None) , ( cell type: B cells, None) , ( cell type: antigen-presenting cells, None) , ( DNA: HLA-DRA, None) , ( protein: class II major histocompatibility complex, None) , ( cell type: T lymphocytes, None) " }

[]

{ "id": "776", "sentence": "In addition, HLA-DRA gene expression is inducible in a variety of cell types by interferon-gamma ( IFN-gamma ).", "label": " ( protein: interferon-gamma, None) , ( DNA: HLA-DRA gene, None) , ( protein: IFN-gamma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interferon-gamma, None) , ( DNA: HLA-DRA gene, None) , ( protein: IFN-gamma, None) " }

[]

{ "id": "777", "sentence": "Here we show that the lymphoid-specific transcription factor Oct-2A plays a critical role in HLA-DRA gene expression in class II-positive B cell lines , and that the high mobility group protein ( HMG ) I/Y binds to multiple sites within the DRA promoter , including the Oct-2A binding site .", "label": " ( protein: lymphoid-specific transcription factor, None) , ( protein: high mobility group protein, None) , ( DNA: HLA-DRA gene, None) , ( protein: Oct-2A, None) , ( DNA: Oct-2A binding site, None) , ( DNA: DRA promoter, None) , ( protein: lymphoid-specific transcription factor Oct-2A, None) , ( protein: HMG, None) , ( protein: Oct-2A, None) , ( protein: I/Y, None) , ( cell line: class II-positive B cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: lymphoid-specific transcription factor, None) , ( protein: high mobility group protein, None) , ( DNA: HLA-DRA gene, None) , ( protein: Oct-2A, None) , ( DNA: Oct-2A binding site, None) , ( DNA: DRA promoter, None) , ( protein: lymphoid-specific transcription factor Oct-2A, None) , ( protein: HMG, None) , ( protein: Oct-2A, None) , ( protein: I/Y, None) , ( cell line: class II-positive B cell lines, None) " }

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{ "id": "778", "sentence": "Coexpression of HMG I/Y and Oct-2 in cell lines lacking Oct-2 results in high levels of HLA-DRA gene expression , and in vitro DNA-binding studies reveal that HMG I/Y stimulates Oct-2A binding to the HLA-DRA promoter .", "label": " ( protein: Oct-2A, None) , ( protein: Oct-2, None) , ( DNA: HLA-DRA promoter, None) , ( protein: I/Y, None) , ( protein: I/Y, None) , ( DNA: HLA-DRA gene, None) , ( protein: HMG I/Y, None) , ( cell line: cell lines, None) , ( protein: Oct-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-2A, None) , ( protein: Oct-2, None) , ( DNA: HLA-DRA promoter, None) , ( protein: I/Y, None) , ( protein: I/Y, None) , ( DNA: HLA-DRA gene, None) , ( protein: HMG I/Y, None) , ( cell line: cell lines, None) , ( protein: Oct-2, None) " }

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{ "id": "779", "sentence": "Thus, Oct-2A and HMG I/Y may synergize to activate HLA-DRA expression in B cells .", "label": " ( cell type: B cells, None) , ( protein: HMG I/Y, None) , ( protein: Oct-2A, None) , ( DNA: HLA-DRA, None) , ( protein: I/Y, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B cells, None) , ( protein: HMG I/Y, None) , ( protein: Oct-2A, None) , ( DNA: HLA-DRA, None) , ( protein: I/Y, None) " }

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{ "id": "780", "sentence": "By contrast, Oct-2A is not involved in the IFN-gamma induction of the HLA-DRA gene in HeLa cells , but antisense HMG I/Y dramatically decreases the level of induction.", "label": " ( protein: HMG I/Y, None) , ( protein: I/Y, None) , ( protein: Oct-2A, None) , ( protein: IFN-gamma, None) , ( DNA: HLA-DRA gene, None) , ( cell line: HeLa cells, None) , ( DNA: antisense HMG I/Y, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HMG I/Y, None) , ( protein: I/Y, None) , ( protein: Oct-2A, None) , ( protein: IFN-gamma, None) , ( DNA: HLA-DRA gene, None) , ( cell line: HeLa cells, None) , ( DNA: antisense HMG I/Y, None) " }

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{ "id": "781", "sentence": "We conclude that distinct sets of transcription factors are involved in the two modes of HLA-DRA expression , and that HMG I/Y may be important for B cell-specific expression , and is essential for IFN-gamma induction .", "label": " ( DNA: HLA-DRA, None) , ( protein: HMG I/Y, None) , ( protein: transcription factors, None) , ( protein: IFN-gamma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: HLA-DRA, None) , ( protein: HMG I/Y, None) , ( protein: transcription factors, None) , ( protein: IFN-gamma, None) " }

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{ "id": "782", "sentence": "Heterogeneous expression of Epstein-Barr virus latent proteins in endemic Burkitt's lymphoma .", "label": " ( protein: Epstein-Barr virus latent proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Epstein-Barr virus latent proteins, None) " }

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{ "id": "783", "sentence": "Epstein-Barr virus (EBV)-infected cells may sustain three distinct forms of virus latency .", "label": " ( cell type: Epstein-Barr virus (EBV)-infected cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: Epstein-Barr virus (EBV)-infected cells, None) " }

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{ "id": "784", "sentence": "In lymphoblastoid cell lines , six EBV-encoded nuclear antigens ( EBNA 1 , 2 , 3A , 3B , 3C , -LP ), three latent membrane proteins ( LMP1 , 2A , 2B ), and two nuclear RNAs ( EBERs ) are expressed.", "label": " ( protein: latent membrane proteins, None) , ( protein: LMP1, None) , ( RNA: nuclear RNAs, None) , ( cell line: lymphoblastoid cell lines, None) , ( RNA: EBERs, None) , ( protein: 2B, None) , ( protein: 2A, None) , ( protein: EBV-encoded nuclear antigens, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: latent membrane proteins, None) , ( protein: LMP1, None) , ( RNA: nuclear RNAs, None) , ( cell line: lymphoblastoid cell lines, None) , ( RNA: EBERs, None) , ( protein: 2B, None) , ( protein: 2A, None) , ( protein: EBV-encoded nuclear antigens, None) " }

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{ "id": "785", "sentence": "This form of latency , termed latency III , is also encountered in some posttransplant lymphoproliferative disorders .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "786", "sentence": "In EBV-positive cases of Hodgkin's disease , the EBERs , EBNA1 , and the LMPs are expressed ( latency II ), whereas in Burkitt's lymphoma (BL) only the EBERs and EBNA1 have been detected ( latency I ).", "label": " ( protein: EBNA1, None) , ( protein: EBNA1, None) , ( RNA: EBERs, None) , ( protein: LMPs, None) , ( RNA: EBERs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: EBNA1, None) , ( protein: EBNA1, None) , ( RNA: EBERs, None) , ( protein: LMPs, None) , ( RNA: EBERs, None) " }

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{ "id": "787", "sentence": "We have studied the expression of EBV proteins in 17 cases of EBV-positive endemic BL by immunohistology .", "label": " ( protein: EBV proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: EBV proteins, None) " }

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{ "id": "788", "sentence": "Expression of LMP1 was seen in variable proportions of tumor cells in two cases and EBNA2 was detected in some tumor cells in three other cases.", "label": " ( cell type: tumor cells, None) , ( protein: LMP1, None) , ( cell type: tumor cells, None) , ( protein: EBNA2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: tumor cells, None) , ( protein: LMP1, None) , ( cell type: tumor cells, None) , ( protein: EBNA2, None) " }

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{ "id": "789", "sentence": "Also, the BZLF1 trans-activator protein was expressed in a few tumor cells in 6 cases, indicating entry into the lytic cycle .", "label": " ( protein: BZLF1 trans-activator protein, None) , ( cell type: tumor cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: BZLF1 trans-activator protein, None) , ( cell type: tumor cells, None) " }

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{ "id": "790", "sentence": "A phenotypic drift from latency I to latency III has been observed previously in some BL cell lines .", "label": " ( cell line: BL cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: BL cell lines, None) " }

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{ "id": "791", "sentence": "Our results suggest that a similar phenomenon may occur in BL in vivo and indicate that the operational definition of EBV latencies is not easily applied to human tumors .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "792", "sentence": "The activation of the Jak -STAT 1 signaling pathway by IL-5 in eosinophils .", "label": " ( protein: -STAT 1, None) , ( cell type: eosinophils, None) , ( protein: Jak, None) , ( protein: IL-5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: -STAT 1, None) , ( cell type: eosinophils, None) , ( protein: Jak, None) , ( protein: IL-5, None) " }

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{ "id": "793", "sentence": "The intracellular signal transduction of IL-5 in eosinophils is unknown.", "label": " ( cell type: eosinophils, None) , ( protein: IL-5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: eosinophils, None) , ( protein: IL-5, None) " }

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{ "id": "794", "sentence": "The objective of this study was to investigate the involvement of the newly discovered Jak -STAT pathway in the IL-5 signal transduction mechanism .", "label": " ( protein: Jak, None) , ( protein: IL-5, None) , ( protein: -STAT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Jak, None) , ( protein: IL-5, None) , ( protein: -STAT, None) " }

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{ "id": "795", "sentence": "Eosinophils were purified from peripheral blood by discontinuous Percoll gradients and stimulated with IL-5 .", "label": " ( protein: IL-5, None) , ( cell type: Eosinophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-5, None) , ( cell type: Eosinophils, None) " }

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{ "id": "796", "sentence": "The involvement of Jak 2 was investigated by immunoprecipitation followed by immunoblotting for tyrosine phosphorylation .", "label": " ( protein: Jak 2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Jak 2, None) " }

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{ "id": "797", "sentence": "The activation of Jak 2 was studied by autophosphorylation of the immunoprecipitated kinase .", "label": " ( protein: Jak 2, None) , ( protein: immunoprecipitated kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Jak 2, None) , ( protein: immunoprecipitated kinase, None) " }

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{ "id": "798", "sentence": "Jak 2 was tyrosine phosphorylated within 1 to 3 min after stimulation of eosinophils with IL-5 .", "label": " ( protein: Jak 2, None) , ( protein: IL-5, None) , ( cell type: eosinophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Jak 2, None) , ( protein: IL-5, None) , ( cell type: eosinophils, None) " }

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{ "id": "799", "sentence": "Further, the immunoprecipitated Jak 2 obtained from IL-5 -stimulated cells underwent autophosphorylation .", "label": " ( protein: IL-5, None) , ( protein: Jak 2, None) , ( cell line: IL-5 -stimulated cells, None) , ( protein: immunoprecipitated Jak 2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-5, None) , ( protein: Jak 2, None) , ( cell line: IL-5 -stimulated cells, None) , ( protein: immunoprecipitated Jak 2, None) " }