Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "800", "sentence": "Jak 2 coprecipitated with the beta-subunit of the IL-5 receptor , suggesting a physical association of the kinase with the receptor.", "label": " ( protein: IL-5, None) , ( protein: kinase, None) , ( protein: IL-5 receptor, None) , ( protein: Jak 2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-5, None) , ( protein: kinase, None) , ( protein: IL-5 receptor, None) , ( protein: Jak 2, None) " }

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{ "id": "801", "sentence": "The nuclear factor STAT-1 ( p91 ) was investigated by immunoprecipitation followed by immunoblotting for tyrosine phosphorylation .", "label": " ( protein: nuclear factor STAT-1, None) , ( protein: p91, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor STAT-1, None) , ( protein: p91, None) " }

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{ "id": "802", "sentence": "STAT-1 was tyrosine phosphorylated within 15 min of IL-5 stimulation .", "label": " ( protein: IL-5, None) , ( protein: STAT-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-5, None) , ( protein: STAT-1, None) " }

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{ "id": "803", "sentence": "The presence of STAT-1 in the nuclear extract was studied by electrophoretic mobility shift assay .", "label": " ( protein: STAT-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: STAT-1, None) " }

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{ "id": "804", "sentence": "IL-5 induced two proteins that bound to the gamma-activating sequence .", "label": " ( protein: IL-5, None) , ( DNA: gamma-activating sequence, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-5, None) , ( DNA: gamma-activating sequence, None) " }

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{ "id": "805", "sentence": "In the presence of an anti- STAT-1 Ab , the band was supershifted.", "label": " ( protein: STAT-1, None) , ( protein: anti- STAT-1 Ab, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: STAT-1, None) , ( protein: anti- STAT-1 Ab, None) " }

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{ "id": "806", "sentence": "Thus, we demonstrated that IL-5 activated the Jak 2 -STAT 1 signaling pathway in eosinophils .", "label": " ( protein: Jak 2, None) , ( protein: IL-5, None) , ( cell type: eosinophils, None) , ( protein: -STAT 1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Jak 2, None) , ( protein: IL-5, None) , ( cell type: eosinophils, None) , ( protein: -STAT 1, None) " }

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{ "id": "807", "sentence": "We speculate that the Jak 2 -STAT 1 pathway may be involved in the activation of IL-5 -inducible genes in eosinophils .", "label": " ( DNA: IL-5 -inducible genes, None) , ( cell type: eosinophils, None) , ( protein: IL-5, None) , ( protein: Jak 2, None) , ( protein: -STAT 1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IL-5 -inducible genes, None) , ( cell type: eosinophils, None) , ( protein: IL-5, None) , ( protein: Jak 2, None) , ( protein: -STAT 1, None) " }

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{ "id": "808", "sentence": "Reduced mitogenic stimulation of peripheral blood mononuclear cells as a prognostic parameter for the course of breast cancer : a prospective longitudinal study .", "label": " ( cell type: peripheral blood mononuclear cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral blood mononuclear cells, None) " }

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{ "id": "809", "sentence": "Immunosuppression has been often associated with the course of malignant diseases .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "810", "sentence": "In the present study, the proliferation of peripheral blood mononuclear cells ( PBMCs ) in response to mitogenic stimulation with phytohaemagglutinin ( PHA ) was assessed prospectively in 90 patients with stage I-III breast cancer .", "label": " ( cell type: PBMCs, None) , ( protein: PHA, None) , ( protein: phytohaemagglutinin, None) , ( cell type: peripheral blood mononuclear cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PBMCs, None) , ( protein: PHA, None) , ( protein: phytohaemagglutinin, None) , ( cell type: peripheral blood mononuclear cells, None) " }

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{ "id": "811", "sentence": "Whereas PHA -induced proliferation of PBMCs derived from patients with breast cancer preoperatively was significantly decreased when compared with data obtained in healthy control individuals (P < 0.001), the degree of the defect in PHA -induced proliferation of PBMCs depended upon the tumour burden as manifested by tumour size and axillary lymph node involvement (P < 0.003 in each case).", "label": " ( cell type: PBMCs, None) , ( protein: PHA, None) , ( protein: PHA, None) , ( cell type: PBMCs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PBMCs, None) , ( protein: PHA, None) , ( protein: PHA, None) , ( cell type: PBMCs, None) " }

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{ "id": "812", "sentence": "PHA -induced proliferation of PBMCs dropped significantly in patients who received adjuvant chemotherapy consisting of cyclophosphamide , methotrexate and fluorouracil ( CMF ) after an observation period of 6 months (P < 0.01), but not in patients under adjuvant treatment with tamoxifen only.", "label": " ( cell type: PBMCs, None) , ( protein: PHA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PBMCs, None) , ( protein: PHA, None) " }

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{ "id": "813", "sentence": "After an additional 6 months (i.e. 12 months after surgery), PHA -induced proliferation of PBMCs was similar in patients after adjuvant chemotherapy with CMF and in those receiving continued adjuvant tamoxifen treatment (P > 0.1), but in all patients still significantly decreased as compared with healthy controls (P < 0.001).", "label": " ( protein: PHA, None) , ( cell type: PBMCs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PHA, None) , ( cell type: PBMCs, None) " }

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{ "id": "814", "sentence": "When data obtained preoperatively and after 12 months were compared, it was found that out of 23 patients whose PBMCs had experienced a drop in their PHA -induced proliferation , 14 (61%) had developed metastatic disease within the subsequent 24 months (i.e. 36 months after surgery).", "label": " ( cell type: PBMCs, None) , ( protein: PHA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PBMCs, None) , ( protein: PHA, None) " }

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{ "id": "815", "sentence": "In contrast, out of 59 patients whose PBMCs showed an increase in their PHA -induced proliferation within the first 12 months after surgery, only one (2%) presented with disease progression .", "label": " ( cell type: PBMCs, None) , ( protein: PHA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PBMCs, None) , ( protein: PHA, None) " }

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{ "id": "816", "sentence": "We thus conclude that PHA -induced proliferation of PBMCs derived from patients with breast cancer depends upon the tumour load and is a good clinical predictor for the further course of the disease.", "label": " ( cell type: PBMCs, None) , ( protein: PHA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PBMCs, None) , ( protein: PHA, None) " }

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{ "id": "817", "sentence": "Activation of transcription by binding of NF-E1 ( YY1 ) to a newly identified element in the first exon of the human DR alpha gene .", "label": " ( protein: NF-E1, None) , ( protein: YY1, None) , ( DNA: human DR alpha gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-E1, None) , ( protein: YY1, None) , ( DNA: human DR alpha gene, None) " }

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{ "id": "818", "sentence": "A previously unrecognized element, located downstream of the start site of transcription in the first exon of the DR alpha gene , has been defined that enhances promoter activity up to eightfold in a position-dependent manner .", "label": " ( DNA: DR alpha gene, None) , ( DNA: exon, None) , ( DNA: start site of transcription, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: DR alpha gene, None) , ( DNA: exon, None) , ( DNA: start site of transcription, None) " }

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{ "id": "819", "sentence": "Mutations in this DNA-binding site abolished binding of a nuclear factor in human B cell nuclear extract and decreased the activity of the DR alpha promoter to a basal level .", "label": " ( protein: nuclear factor, None) , ( DNA: DNA-binding site, None) , ( DNA: DR alpha promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor, None) , ( DNA: DNA-binding site, None) , ( DNA: DR alpha promoter, None) " }

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{ "id": "820", "sentence": "Significant sequence homology of this element was found in the DNA of the DR beta , DP alpha and -beta , and DQ alpha genes , always located downstream of the transcriptional start site .", "label": " ( DNA: transcriptional start site, None) , ( DNA: element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: transcriptional start site, None) , ( DNA: element, None) " }

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{ "id": "821", "sentence": "The nuclear factor binds to the DR alpha and DP alpha element but not to the element in the DQ alpha gene .", "label": " ( DNA: DQ alpha gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: DQ alpha gene, None) " }

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{ "id": "822", "sentence": "It was identified as NF-E1 ( YY1 ).", "label": " ( protein: NF-E1, None) , ( protein: YY1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-E1, None) , ( protein: YY1, None) " }

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{ "id": "823", "sentence": "This protein, previously identified by its binding to the Ig kappa 3' enhancer and the Ig heavy chain mu E1 site , thus also appears to be quite important in the regulation of MHC class II gene expression .", "label": " ( DNA: Ig heavy chain mu E1 site, None) , ( DNA: MHC class II gene, None) , ( DNA: Ig kappa 3#$%# enhancer, None) , ( protein: Ig heavy chain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Ig heavy chain mu E1 site, None) , ( DNA: MHC class II gene, None) , ( DNA: Ig kappa 3#$%# enhancer, None) , ( protein: Ig heavy chain, None) " }

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{ "id": "824", "sentence": "Transcriptional activity of core binding factor- alpha (AML1) and beta subunits on murine leukemia virus enhancer cores .", "label": " ( DNA: murine leukemia virus enhancer cores, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: murine leukemia virus enhancer cores, None) " }

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{ "id": "825", "sentence": "Core binding factor ( CBF ), also known as polyomavirus enhancer-binding protein 2 and SL3 enhancer factor 1 , is a mammalian transcription factor that binds to an element termed the core within the enhancers of the murine leukemia virus family of retroviruses .", "label": " ( DNA: enhancers, None) , ( protein: Core binding factor, None) , ( protein: SL3 enhancer factor 1, None) , ( protein: CBF, None) , ( protein: polyomavirus enhancer-binding protein 2, None) , ( protein: mammalian transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: enhancers, None) , ( protein: Core binding factor, None) , ( protein: SL3 enhancer factor 1, None) , ( protein: CBF, None) , ( protein: polyomavirus enhancer-binding protein 2, None) , ( protein: mammalian transcription factor, None) " }

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{ "id": "826", "sentence": "The core elements of the SL3 virus are important genetic determinants of the ability of this virus to induce T-cell lymphomas and the transcriptional activity of the viral long terminal repeat in T lymphocytes .", "label": " ( cell type: T lymphocytes, None) , ( DNA: core elements, None) , ( DNA: viral long terminal repeat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T lymphocytes, None) , ( DNA: core elements, None) , ( DNA: viral long terminal repeat, None) " }

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{ "id": "827", "sentence": "CBF consists of two subunits, a DNA binding subunit , CBF alpha , and a second subunit, CBF beta , that stimulates the DNA binding activity of CBF alpha .", "label": " ( protein: DNA binding subunit, None) , ( protein: CBF alpha, None) , ( protein: CBF beta, None) , ( protein: CBF alpha, None) , ( protein: CBF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNA binding subunit, None) , ( protein: CBF alpha, None) , ( protein: CBF beta, None) , ( protein: CBF alpha, None) , ( protein: CBF, None) " }

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{ "id": "828", "sentence": "One of the genes that encodes a CBF alpha subunit is AML1 , also called Cbf alpha 2 .", "label": " ( protein: CBF alpha, None) , ( protein: Cbf alpha 2, None) , ( protein: CBF alpha subunit, None) , ( protein: AML1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CBF alpha, None) , ( protein: Cbf alpha 2, None) , ( protein: CBF alpha subunit, None) , ( protein: AML1, None) " }

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{ "id": "829", "sentence": "This locus is rearranged by chromosomal translocations in human myeloproliferative disorders and leukemias .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "830", "sentence": "An exogenously expressed Cbf alpha 2 -encoded subunit ( CBF alpha 2-451 ) stimulated transcription from the SL3 enhancer in P19 and HeLa cells .", "label": " ( cell line: HeLa cells, None) , ( protein: Cbf alpha 2, None) , ( DNA: SL3 enhancer, None) , ( protein: CBF alpha 2-451, None) , ( protein: P19, None) , ( protein: CBF alpha, None) , ( protein: Cbf alpha 2 -encoded subunit, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HeLa cells, None) , ( protein: Cbf alpha 2, None) , ( DNA: SL3 enhancer, None) , ( protein: CBF alpha 2-451, None) , ( protein: P19, None) , ( protein: CBF alpha, None) , ( protein: Cbf alpha 2 -encoded subunit, None) " }

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{ "id": "831", "sentence": "Activity was mediated through the core elements .", "label": " ( DNA: core elements, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: core elements, None) " }

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{ "id": "832", "sentence": "Three different isoforms of CBF beta were also tested for transcriptional activity on the SL3 enhancer .", "label": " ( protein: CBF beta, None) , ( DNA: SL3 enhancer, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CBF beta, None) , ( DNA: SL3 enhancer, None) " }

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{ "id": "833", "sentence": "The longest form, CBF beta -187 , increased the transcriptional stimulation by CBF alpha 2-451 twofold in HeLa cells , although it had no effect in P19 cells .", "label": " ( protein: CBF alpha 2-451, None) , ( cell line: P19 cells, None) , ( cell line: HeLa cells, None) , ( protein: P19, None) , ( protein: CBF beta -187, None) , ( protein: CBF beta, None) , ( protein: CBF alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CBF alpha 2-451, None) , ( cell line: P19 cells, None) , ( cell line: HeLa cells, None) , ( protein: P19, None) , ( protein: CBF beta -187, None) , ( protein: CBF beta, None) , ( protein: CBF alpha, None) " }

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{ "id": "834", "sentence": "Transcriptional activation by CBF beta required binding to the CBF alpha subunit , as a form of CBF beta that lacked binding ability, CBF beta -148 , failed to increase activity.", "label": " ( protein: CBF beta, None) , ( protein: CBF beta -148, None) , ( protein: CBF alpha, None) , ( protein: CBF beta, None) , ( protein: CBF alpha subunit, None) , ( protein: CBF beta, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CBF beta, None) , ( protein: CBF beta -148, None) , ( protein: CBF alpha, None) , ( protein: CBF beta, None) , ( protein: CBF alpha subunit, None) , ( protein: CBF beta, None) " }

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{ "id": "835", "sentence": "These results indicated that at least in certain cell types, the maximum activity of CBF required both subunits.", "label": " ( protein: CBF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CBF, None) " }

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{ "id": "836", "sentence": "They also provided support for the hypothesis that CBF is a factor in T lymphocytes that is responsible for recognition of the SL3 cores .", "label": " ( DNA: SL3 cores, None) , ( cell type: T lymphocytes, None) , ( protein: CBF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: SL3 cores, None) , ( cell type: T lymphocytes, None) , ( protein: CBF, None) " }

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{ "id": "837", "sentence": "We also examined whether CBF could distinguish a 1-bp difference between the enhancer core of SL3 and the core of the nonleukemogenic virus , Akv .", "label": " ( DNA: enhancer core of SL3, None) , ( protein: CBF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: enhancer core of SL3, None) , ( protein: CBF, None) " }

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{ "id": "838", "sentence": "This difference strongly affects transcription in T cells and leukemogenicity of SL3 .", "label": " ( DNA: SL3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: SL3, None) " }

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{ "id": "839", "sentence": "However, no combination of CBF alpha and CBF beta subunits that we tested was able to distinguish the 1-bp difference in transcription assays .", "label": " ( protein: CBF alpha, None) , ( protein: CBF beta, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CBF alpha, None) , ( protein: CBF beta, None) " }

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{ "id": "840", "sentence": "Thus, a complete understanding of how T cells recognize the SL3 core remains to be elucidated.", "label": " ( cell type: T cells, None) , ( DNA: SL3 core, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( DNA: SL3 core, None) " }

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{ "id": "841", "sentence": "Interleukin (IL)-10 inhibits nuclear factor kappa B ( NF kappa B ) activation in human monocytes .", "label": " ( protein: NF kappa B, None) , ( protein: nuclear factor kappa B, None) , ( cell type: human monocytes, None) , ( protein: Interleukin (IL)-10, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF kappa B, None) , ( protein: nuclear factor kappa B, None) , ( cell type: human monocytes, None) , ( protein: Interleukin (IL)-10, None) " }

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{ "id": "842", "sentence": "IL-10 and IL-4 suppress cytokine synthesis by different mechanisms.", "label": " ( protein: IL-4, None) , ( protein: cytokine, None) , ( protein: IL-10, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-4, None) , ( protein: cytokine, None) , ( protein: IL-10, None) " }

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{ "id": "843", "sentence": "Our previous studies in human monocytes have demonstrated that interleukin (IL)-10 inhibits lipopolysaccharide (LPS)-stimulated production of inflammatory cytokines , IL-1 beta , IL-6 , IL-8 , and tumor necrosis factor (TNF)-alpha by blocking gene transcription .", "label": " ( protein: inflammatory cytokines, None) , ( protein: IL-8, None) , ( protein: IL-6, None) , ( protein: IL-1 beta, None) , ( protein: interleukin (IL)-10, None) , ( cell type: human monocytes, None) , ( protein: tumor necrosis factor (TNF)-alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: inflammatory cytokines, None) , ( protein: IL-8, None) , ( protein: IL-6, None) , ( protein: IL-1 beta, None) , ( protein: interleukin (IL)-10, None) , ( cell type: human monocytes, None) , ( protein: tumor necrosis factor (TNF)-alpha, None) " }

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{ "id": "844", "sentence": "Using electrophoretic mobility shift assays ( EMSA ), we now show that, in monocytes stimulated with LPS or TNF alpha , IL-10 inhibits nuclear stimulation of nuclear factor kappa B ( NF kappa B ), a transcription factor involved in the expression of inflammatory cytokine genes . Several other transcription factors including NF- IL-6 , AP-1 , AP-2 , GR , CREB , Oct-1 , and Sp-1 are not affected by IL-10 .", "label": " ( protein: GR, None) , ( protein: Sp-1, None) , ( protein: transcription factor, None) , ( protein: IL-10, None) , ( protein: IL-10, None) , ( protein: TNF alpha, None) , ( protein: CREB, None) , ( protein: nuclear factor kappa B, None) , ( protein: NF kappa B, None) , ( DNA: inflammatory cytokine genes, None) , ( protein: AP-1, None) , ( protein: IL-6, None) , ( protein: transcription factors, None) , ( protein: Oct-1, None) , ( protein: AP-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GR, None) , ( protein: Sp-1, None) , ( protein: transcription factor, None) , ( protein: IL-10, None) , ( protein: IL-10, None) , ( protein: TNF alpha, None) , ( protein: CREB, None) , ( protein: nuclear factor kappa B, None) , ( protein: NF kappa B, None) , ( DNA: inflammatory cytokine genes, None) , ( protein: AP-1, None) , ( protein: IL-6, None) , ( protein: transcription factors, None) , ( protein: Oct-1, None) , ( protein: AP-2, None) " }

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{ "id": "845", "sentence": "This selective inhibition by IL-10 of NF kappa B activation occurs rapidly and in a dose-dependent manner and correlates well with IL-10 's cytokine synthesis inhibitory activity in terms of both kinetics and dose responsiveness .", "label": " ( protein: NF kappa B, None) , ( protein: IL-10, None) , ( protein: IL-10, None) , ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF kappa B, None) , ( protein: IL-10, None) , ( protein: IL-10, None) , ( protein: cytokine, None) " }

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{ "id": "846", "sentence": "Furthermore, compounds such as tosylphenylalanyl chloromethyl ketone and pyrrolidinedithiocarbamate that are known to selectively inhibit NF kappa B activation block cytokine gene transcription in LPS -stimulated monocytes .", "label": " ( cell line: LPS -stimulated monocytes, None) , ( protein: NF kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: LPS -stimulated monocytes, None) , ( protein: NF kappa B, None) " }

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{ "id": "847", "sentence": "Taken together, these results suggest that inhibition of NF kappa B activation may be an important mechanism for IL-10 suppression of cytokine gene transcription in human monocytes .", "label": " ( protein: NF kappa B, None) , ( cell type: human monocytes, None) , ( protein: IL-10, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF kappa B, None) , ( cell type: human monocytes, None) , ( protein: IL-10, None) " }

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{ "id": "848", "sentence": "IL-4 , another cytokine that inhibits cytokine mRNA accumulation in monocytes , shows little inhibitory effect on LPS -induced NF kappa B activation .", "label": " ( protein: NF kappa B, None) , ( protein: cytokine, None) , ( RNA: cytokine mRNA, None) , ( protein: IL-4, None) , ( cell type: monocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF kappa B, None) , ( protein: cytokine, None) , ( RNA: cytokine mRNA, None) , ( protein: IL-4, None) , ( cell type: monocytes, None) " }

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{ "id": "849", "sentence": "Further examination reveals that, unlike IL-10 , IL-4 enhances mRNA degradation and does not suppress cytokine gene transcription .", "label": " ( RNA: mRNA, None) , ( protein: IL-10, None) , ( protein: IL-4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: mRNA, None) , ( protein: IL-10, None) , ( protein: IL-4, None) " }

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{ "id": "850", "sentence": "These data indicate that IL-10 and IL-4 inhibit cytokine production by different mechanisms.", "label": " ( protein: IL-4, None) , ( protein: IL-10, None) , ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-4, None) , ( protein: IL-10, None) , ( protein: cytokine, None) " }

[]

{ "id": "851", "sentence": "LMP-1 activates NF-kappa B by targeting the inhibitory molecule I kappa B alpha .", "label": " ( protein: inhibitory molecule I kappa B alpha, None) , ( protein: LMP-1, None) , ( protein: NF-kappa B, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: inhibitory molecule I kappa B alpha, None) , ( protein: LMP-1, None) , ( protein: NF-kappa B, None) , ( protein: I kappa B alpha, None) " }

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{ "id": "852", "sentence": "LMP-1 , an Epstein-Barr virus membrane protein expressed during latent infection , has oncogenic properties , as judged from its ability to transform B lymphocytes and rodent fibroblasts .", "label": " ( protein: Epstein-Barr virus membrane protein, None) , ( cell type: rodent fibroblasts, None) , ( cell type: lymphocytes, None) , ( protein: LMP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Epstein-Barr virus membrane protein, None) , ( cell type: rodent fibroblasts, None) , ( cell type: lymphocytes, None) , ( protein: LMP-1, None) " }

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{ "id": "853", "sentence": "LMP-1 induces the expression of bcl2 , an oncogene which protects cells from apoptosis , as well as of genes encoding other proteins involved in cell regulation and growth control .", "label": " ( protein: LMP-1, None) , ( DNA: bcl2, None) , ( DNA: oncogene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LMP-1, None) , ( DNA: bcl2, None) , ( DNA: oncogene, None) " }

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{ "id": "854", "sentence": "The mechanisms by which LMP-1 upregulates these proteins is unknown, but it is plausible that LMP-1 modifies signal transduction pathways that result in the activation of one or more transcription factors that ultimately regulate transcription of oncogenic genes .", "label": " ( DNA: oncogenic genes, None) , ( protein: LMP-1, None) , ( protein: LMP-1, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: oncogenic genes, None) , ( protein: LMP-1, None) , ( protein: LMP-1, None) , ( protein: transcription factors, None) " }

[]

{ "id": "855", "sentence": "NF-kappa B , a transcription factor controlling the expression of genes involved in cell activation and growth control , has been shown to be activated by LMP-1 .", "label": " ( protein: LMP-1, None) , ( protein: NF-kappa B, None) , ( DNA: genes, None) , ( protein: transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LMP-1, None) , ( protein: NF-kappa B, None) , ( DNA: genes, None) , ( protein: transcription factor, None) " }

[]

{ "id": "856", "sentence": "The mechanism(s) regulating this activation remains unknown.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "857", "sentence": "Our data indicate that increased NF-kappa B DNA binding and functional activity are present in B-lymphoid cells stably or transiently expressing LMP-1 .", "label": " ( protein: NF-kappa B, None) , ( cell type: B-lymphoid cells, None) , ( protein: LMP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( cell type: B-lymphoid cells, None) , ( protein: LMP-1, None) " }

[]

{ "id": "858", "sentence": "I kappa B alpha is selectively modified in LMP-1 -expressing B cells .", "label": " ( protein: I kappa B alpha, None) , ( cell line: LMP-1 -expressing B cells, None) , ( protein: LMP-1, None) , ( cell type: B cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I kappa B alpha, None) , ( cell line: LMP-1 -expressing B cells, None) , ( protein: LMP-1, None) , ( cell type: B cells, None) " }

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{ "id": "859", "sentence": "A phosphorylated form of I kappa B alpha and increased protein turnover-degradation correlate with increased NF-kappa B nuclear translocation .", "label": " ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) " }

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{ "id": "860", "sentence": "This results in increased transcription of NF-kappa B -dependent-genes , including those encoding p105 and I kappa B alpha ( MAD3 ).", "label": " ( DNA: MAD3, None) , ( DNA: NF-kappa B -dependent-genes, None) , ( protein: p105, None) , ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: MAD3, None) , ( DNA: NF-kappa B -dependent-genes, None) , ( protein: p105, None) , ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "861", "sentence": "These results indicate that LMP-1 activates NF-kappa B in B-cell lines by targeting I kappa B alpha .", "label": " ( protein: LMP-1, None) , ( protein: I kappa B alpha, None) , ( cell line: B-cell lines, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LMP-1, None) , ( protein: I kappa B alpha, None) , ( cell line: B-cell lines, None) , ( protein: NF-kappa B, None) " }

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{ "id": "862", "sentence": "Identification of the pathways activated by LMP-1 to result in posttranslational modifications of I kappa B alpha will aid in determining the role of this virus-host cell protein interaction in Epstein-Barr virus -mediated oncogenesis .", "label": " ( protein: LMP-1, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LMP-1, None) , ( protein: I kappa B alpha, None) " }

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{ "id": "863", "sentence": "Identification of human TR2 orphan receptor response element in the transcriptional initiation site of the simian virus 40 major late promoter [published erratum appears in J Biol Chem 1995 Nov 3;270(44):26721]", "label": " ( protein: human TR2 orphan receptor, None) , ( DNA: transcriptional initiation site, None) , ( DNA: simian virus 40 major late promoter, None) , ( DNA: human TR2 orphan receptor response element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: human TR2 orphan receptor, None) , ( DNA: transcriptional initiation site, None) , ( DNA: simian virus 40 major late promoter, None) , ( DNA: human TR2 orphan receptor response element, None) " }

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{ "id": "864", "sentence": "A DNA response element ( TR2RE-SV40 ) for the TR2 orphan receptor , a member of the steroid-thyroid hormone receptor superfamily , has been identified in the simian virus 40 ( SV40 ) +55 region ( nucleotide numbers 368-389 , 5'-GTTAAGGTTCGTAGGTCATGGA-3' ).", "label": " ( DNA: TR2RE-SV40, None) , ( protein: TR2 orphan receptor, None) , ( protein: steroid-thyroid hormone receptor superfamily, None) , ( DNA: simian virus 40 ( SV40 ) +55 region, None) , ( DNA: DNA response element, None) , ( DNA: nucleotide numbers 368-389, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: TR2RE-SV40, None) , ( protein: TR2 orphan receptor, None) , ( protein: steroid-thyroid hormone receptor superfamily, None) , ( DNA: simian virus 40 ( SV40 ) +55 region, None) , ( DNA: DNA response element, None) , ( DNA: nucleotide numbers 368-389, None) " }

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{ "id": "865", "sentence": "Electrophoretic mobility shift assay , using in vitro translated TR2 orphan receptor with a molecular mass of 67 kilodaltons , showed a specific binding with high affinity (dissociation constant = 9 nM) for this DNA sequence .", "label": " ( protein: TR2 orphan receptor, None) , ( DNA: DNA sequence, None) , ( protein: 67 kilodaltons, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TR2 orphan receptor, None) , ( DNA: DNA sequence, None) , ( protein: 67 kilodaltons, None) " }

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{ "id": "866", "sentence": "DNA-swap experiments using chloramphenicol acetyl-transferase assay demonstrated that androgen can suppress the transcriptional activities of SV40 early promoter via the interaction between this TR2RE- SV40 and the chimeric receptor AR/TR2/AR with the DNA-binding domain of the TR2 orphan receptor flanked by the N-terminal and androgen-binding domains of the androgen receptor .", "label": " ( protein: TR2RE- SV40, None) , ( protein: androgen receptor, None) , ( protein: chloramphenicol acetyl-transferase, None) , ( protein: chimeric receptor AR/TR2/AR, None) , ( protein: DNA-binding domain, None) , ( DNA: SV40 early promoter, None) , ( protein: TR2 orphan receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TR2RE- SV40, None) , ( protein: androgen receptor, None) , ( protein: chloramphenicol acetyl-transferase, None) , ( protein: chimeric receptor AR/TR2/AR, None) , ( protein: DNA-binding domain, None) , ( DNA: SV40 early promoter, None) , ( protein: TR2 orphan receptor, None) " }

[]

{ "id": "867", "sentence": "In addition, this TR2RE- SV40 can function as a repressor to suppress the transcriptional activities of both SV40 early and late promoters .", "label": " ( DNA: TR2RE- SV40, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: TR2RE- SV40, None) " }

[]

{ "id": "868", "sentence": "Together, these data suggest the TR2RE- SV40 may represent the first identified natural DNA response element for the TR2 orphan receptor that may function as a repressor for the SV40 gene expression .", "label": " ( DNA: TR2RE- SV40, None) , ( DNA: DNA response element, None) , ( protein: TR2 orphan receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: TR2RE- SV40, None) , ( DNA: DNA response element, None) , ( protein: TR2 orphan receptor, None) " }

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{ "id": "869", "sentence": "Detection of the chromosome 16 CBF beta-MYH11 fusion transcript in myelomonocytic leukemias .", "label": " ( RNA: chromosome 16 CBF beta-MYH11 fusion transcript, None) , ( DNA: chromosome 16, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: chromosome 16 CBF beta-MYH11 fusion transcript, None) , ( DNA: chromosome 16, None) " }

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{ "id": "870", "sentence": "Karyotypic detection of chromosomal 16 abnormalities classically associated with AML M4Eo can be difficult.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "871", "sentence": "Characterization of the two genes involved in the inv(16)(p13q22) , CBF beta and MYH11 , has allowed the detection of fusion transcripts by reverse-transcriptase polymerase chain reaction ( RT-PCR ).", "label": " ( RNA: fusion transcripts, None) , ( DNA: CBF beta, None) , ( DNA: MYH11, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: fusion transcripts, None) , ( DNA: CBF beta, None) , ( DNA: MYH11, None) " }

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{ "id": "872", "sentence": "We have analyzed CBF beta -MYH11 fusion transcripts by RT-PCR in myelomonocytic leukemias , with or without eosinophilia , to determine whether their presence correlates with morphology.", "label": " ( DNA: CBF beta, None) , ( DNA: -MYH11, None) , ( RNA: CBF beta -MYH11 fusion transcripts, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: CBF beta, None) , ( DNA: -MYH11, None) , ( RNA: CBF beta -MYH11 fusion transcripts, None) " }

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{ "id": "873", "sentence": "Fifty-three cases (11 AML M4Eo ; 1 AML M4 with atypical abnormal eosinophils (AML M4 \"Eo\"); 29 AML M4 ; 8 AML M5 ; 3 CMML ; and 1 AML M2 with eosinophilia ) were analyzed.", "label": " ( cell type: atypical abnormal eosinophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: atypical abnormal eosinophils, None) " }

[]

{ "id": "874", "sentence": "All 11 typical AML M4Eo were CBF beta -MYH11 positive.", "label": " ( DNA: -MYH11, None) , ( DNA: CBF beta, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: -MYH11, None) , ( DNA: CBF beta, None) " }

[]

{ "id": "875", "sentence": "The single case of AML M4 with distinctive eosinophil abnormalities was negative by karyotype , RT-PCR and fluorescent in situ hybridization ( FISH ).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "876", "sentence": "Three of 29 (10%) AML M4 without abnormal eosinophils were CBF beta -MYH11 positive, 1 of which did not show any apparent chromosome 16 abnormalities by classical metaphase analysis (2 not tested).", "label": " ( DNA: CBF beta, None) , ( DNA: chromosome 16, None) , ( DNA: -MYH11, None) , ( cell type: abnormal eosinophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: CBF beta, None) , ( DNA: chromosome 16, None) , ( DNA: -MYH11, None) , ( cell type: abnormal eosinophils, None) " }

[]

{ "id": "877", "sentence": "Both cases tested also showed MYH11 genomic rearrangement .", "label": " ( DNA: MYH11, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: MYH11, None) " }

[]

{ "id": "878", "sentence": "None of the other leukemias were RT-PCR positive.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "879", "sentence": "Follow-up of three patient showed residual positivity in apparent complete remission.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "880", "sentence": "These data show that CBF beta -MYH11 fusion transcripts occur not only in the vast majority of typical AML M4Eo , but also in approximately 10% of AML M4 without eosinophilic abnormalities , a much higher incidence than the sporadic reports of chromosome 16 abnormalities in AML M4 would suggest.", "label": " ( RNA: CBF beta -MYH11 fusion transcripts, None) , ( DNA: chromosome 16, None) , ( DNA: CBF beta, None) , ( DNA: -MYH11, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: CBF beta -MYH11 fusion transcripts, None) , ( DNA: chromosome 16, None) , ( DNA: CBF beta, None) , ( DNA: -MYH11, None) " }

[]

{ "id": "881", "sentence": "Taken together with the detection of CBF beta - MYH11 transcripts in the absence of apparent chromosome 16 abnormalities by classical banding techniques, these data show that additional screening by either RT-PCR or FISH should be performed in all AML M4 , regardless of morphologic features, to allow accurate evaluation of the prognostic importance of this fusion transcript .", "label": " ( RNA: MYH11 transcripts, None) , ( RNA: fusion transcript, None) , ( DNA: chromosome 16, None) , ( DNA: CBF beta, None) , ( DNA: MYH11, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: MYH11 transcripts, None) , ( RNA: fusion transcript, None) , ( DNA: chromosome 16, None) , ( DNA: CBF beta, None) , ( DNA: MYH11, None) " }

[]

{ "id": "882", "sentence": "HIV-1 Tat potentiates TNF -induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.", "label": " ( protein: NF-kappa B, None) , ( protein: TNF, None) , ( protein: HIV-1 Tat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: TNF, None) , ( protein: HIV-1 Tat, None) " }

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{ "id": "883", "sentence": "This study demonstrates that human immunodeficiency virus type 1 ( HIV-1 ) Tat protein amplifies the activity of tumor necrosis factor ( TNF ), a cytokine that stimulates HIV-1 replication through activation of NF-kappa B .", "label": " ( protein: human immunodeficiency virus type 1 ( HIV-1 ) Tat protein, None) , ( protein: NF-kappa B, None) , ( protein: tumor necrosis factor, None) , ( protein: TNF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: human immunodeficiency virus type 1 ( HIV-1 ) Tat protein, None) , ( protein: NF-kappa B, None) , ( protein: tumor necrosis factor, None) , ( protein: TNF, None) " }

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{ "id": "884", "sentence": "In HeLa cells stably transfected with the HIV-1 tat gene ( HeLa-tat cells ), expression of the Tat protein enhanced both TNF -induced activation of NF-kappa B and TNF -mediated cytotoxicity .", "label": " ( protein: TNF, None) , ( cell line: HeLa-tat cells, None) , ( protein: Tat protein, None) , ( DNA: HIV-1 tat gene, None) , ( cell line: HeLa cells, None) , ( protein: TNF, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF, None) , ( cell line: HeLa-tat cells, None) , ( protein: Tat protein, None) , ( DNA: HIV-1 tat gene, None) , ( cell line: HeLa cells, None) , ( protein: TNF, None) , ( protein: NF-kappa B, None) " }

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{ "id": "885", "sentence": "A similar potentiation of TNF effects was observed in Jurkat T cells and HeLa cells treated with soluble Tat protein .", "label": " ( cell line: HeLa cells, None) , ( protein: TNF, None) , ( protein: Tat protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HeLa cells, None) , ( protein: TNF, None) , ( protein: Tat protein, None) " }

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{ "id": "886", "sentence": "TNF -mediated activation of NF-kappa B and cytotoxicity involves the intracellular formation of reactive oxygen intermediates .", "label": " ( protein: TNF, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF, None) , ( protein: NF-kappa B, None) " }

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{ "id": "887", "sentence": "Therefore, Tat -mediated effects on the cellular redox state were analyzed.", "label": " ( protein: Tat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tat, None) " }

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{ "id": "888", "sentence": "In both T cells and HeLa cells HIV-1 Tat suppressed the expression of Mn-dependent superoxide dismutase ( Mn-SOD ), a mitochondrial enzyme that is part of the cellular defense system against oxidative stress .", "label": " ( cell line: HeLa cells, None) , ( protein: HIV-1 Tat, None) , ( protein: mitochondrial enzyme, None) , ( protein: Mn-SOD, None) , ( protein: Mn-dependent superoxide dismutase, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HeLa cells, None) , ( protein: HIV-1 Tat, None) , ( protein: mitochondrial enzyme, None) , ( protein: Mn-SOD, None) , ( protein: Mn-dependent superoxide dismutase, None) , ( cell type: T cells, None) " }

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{ "id": "889", "sentence": "Thus, Mn-SOD RNA protein levels and activity were markedly reduced in the presence of Tat .", "label": " ( protein: Tat, None) , ( protein: Mn-SOD, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tat, None) , ( protein: Mn-SOD, None) " }

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{ "id": "890", "sentence": "Decreased Mn-SOD expression was associated with decreased levels of glutathione and a lower ratio of reduced:oxidized glutathione .", "label": " ( protein: Mn-SOD, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Mn-SOD, None) " }

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{ "id": "891", "sentence": "A truncated Tat protein ( Tat1-72 ), known to transactivate the HIV-1 long terminal repeat ( LTR ), no longer affected Mn-SOD expression , the cellular redox state or TNF -mediated cytotoxicity .", "label": " ( protein: Tat, None) , ( protein: TNF, None) , ( protein: Tat1-72, None) , ( DNA: LTR, None) , ( protein: Tat protein, None) , ( DNA: HIV-1 long terminal repeat, None) , ( protein: Mn-SOD, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tat, None) , ( protein: TNF, None) , ( protein: Tat1-72, None) , ( DNA: LTR, None) , ( protein: Tat protein, None) , ( DNA: HIV-1 long terminal repeat, None) , ( protein: Mn-SOD, None) " }

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{ "id": "892", "sentence": "Thus, our experiments demonstrate that the C-terminal region of HIV-1 Tat is required to suppress Mn-SOD expression and to induce pro-oxidative conditions reflected by a drop in reduced glutathione ( GSH ) and the GSH:oxidized GSH ( GSSG ) ratio .", "label": " ( protein: Tat, None) , ( protein: Mn-SOD, None) , ( protein: HIV-1 Tat, None) , ( protein: GSH, None) , ( protein: C-terminal region, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tat, None) , ( protein: Mn-SOD, None) , ( protein: HIV-1 Tat, None) , ( protein: GSH, None) , ( protein: C-terminal region, None) " }

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{ "id": "893", "sentence": "(ABSTRACT TRUNCATED AT 250 WORDS)", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "894", "sentence": "The use of glucocorticoids in acute lymphoblastic leukemia of childhood.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "895", "sentence": "Molecular, cellular, and clinical considerations.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "896", "sentence": "Glucocorticoids have been included in almost all treatment regimens for childhood acute lymphoblastic leukemia for decades.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "897", "sentence": "However, optimal agents, doses, and/or schedules have yet to be defined despite extensive clinical application.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "898", "sentence": "New data on the pharmacokinetics , pharmacodynamics , and molecular mechanisms of action of glucocorticoids have suggested alternative approaches in ALL .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "899", "sentence": "These suggest that prolonged, i.e. 28 day, glucocorticoid therapy may be unnecessary as exposure to glucocorticoid induces down-regulation of glucocorticoid receptors .", "label": " ( protein: glucocorticoid receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptors, None) " }