Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "1100", "sentence": "Deletion of the NF-kappa B elements of the HIV-1 LTR significantly inhibited Tat -mediated transactivation in T-cell lines , as well as in a monocyte line , U937 .", "label": " ( protein: NF-kappa B, None) , ( cell line: U937, None) , ( cell line: monocyte line, None) , ( DNA: NF-kappa B elements, None) , ( cell line: T-cell lines, None) , ( protein: Tat, None) , ( DNA: HIV-1 LTR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( cell line: U937, None) , ( cell line: monocyte line, None) , ( DNA: NF-kappa B elements, None) , ( cell line: T-cell lines, None) , ( protein: Tat, None) , ( DNA: HIV-1 LTR, None) " }

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{ "id": "1101", "sentence": "Replacement of the NF-kappa B elements in the HIV-1 LTR by a DNA fragment derived from the 5'-flanking region of IFN-stimulated gene 15 ( ISG15 ), containing the IFN-stimulated response element , partially restored Tat -mediated activation of LTR in T cells as well as in monocytes .", "label": " ( cell type: monocytes, None) , ( DNA: IFN-stimulated gene 15, None) , ( DNA: ISG15, None) , ( DNA: IFN-stimulated response element, None) , ( cell type: T cells, None) , ( DNA: DNA fragment, None) , ( DNA: NF-kappa B elements, None) , ( DNA: HIV-1 LTR, None) , ( DNA: LTR, None) , ( protein: NF-kappa B, None) , ( protein: Tat, None) , ( DNA: 5#$%#-flanking region, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytes, None) , ( DNA: IFN-stimulated gene 15, None) , ( DNA: ISG15, None) , ( DNA: IFN-stimulated response element, None) , ( cell type: T cells, None) , ( DNA: DNA fragment, None) , ( DNA: NF-kappa B elements, None) , ( DNA: HIV-1 LTR, None) , ( DNA: LTR, None) , ( protein: NF-kappa B, None) , ( protein: Tat, None) , ( DNA: 5#$%#-flanking region, None) " }

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{ "id": "1102", "sentence": "Insertion of this chimeric promoter ( ISG15 LTR ) upstream of the human IFNA2 gene directed high levels of IFN synthesis in Tat-expressing cells , while this promoter was not responsive to tumor necrosis factor alpha -mediated activation .", "label": " ( protein: tumor necrosis factor alpha, None) , ( protein: IFN, None) , ( DNA: ISG15 LTR, None) , ( cell line: Tat-expressing cells, None) , ( DNA: chimeric promoter, None) , ( DNA: human IFNA2 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tumor necrosis factor alpha, None) , ( protein: IFN, None) , ( DNA: ISG15 LTR, None) , ( cell line: Tat-expressing cells, None) , ( DNA: chimeric promoter, None) , ( DNA: human IFNA2 gene, None) " }

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{ "id": "1103", "sentence": "ISG15-LTR-IFN hybrid gene inserted into the retrovirus vector was transduced into Jurkat and U937 cells .", "label": " ( cell line: Jurkat, None) , ( DNA: ISG15-LTR-IFN hybrid gene, None) , ( DNA: retrovirus vector, None) , ( cell line: U937 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Jurkat, None) , ( DNA: ISG15-LTR-IFN hybrid gene, None) , ( DNA: retrovirus vector, None) , ( cell line: U937 cells, None) " }

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{ "id": "1104", "sentence": "Selected transfected clones produced low levels of IFN A ( IFNA ) constitutively, and their abilities to express interleukin-2 and interleukin-2 receptor upon stimulation with phytohemagglutinin and phorbol myristate acetate were retained.", "label": " ( protein: interleukin-2, None) , ( protein: interleukin-2, None) , ( protein: IFN A, None) , ( protein: interleukin-2 receptor, None) , ( protein: IFNA, None) , ( cell line: transfected clones, None) , ( protein: phytohemagglutinin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin-2, None) , ( protein: interleukin-2, None) , ( protein: IFN A, None) , ( protein: interleukin-2 receptor, None) , ( protein: IFNA, None) , ( cell line: transfected clones, None) , ( protein: phytohemagglutinin, None) " }

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{ "id": "1105", "sentence": "Enhancement of IFNA synthesis observed upon HIV-1 infection resulted in significant inhibition of HIV-1 replication for a period of at least 30 days.", "label": " ( protein: IFNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFNA, None) " }

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{ "id": "1106", "sentence": "Virus isolated from IFNA -producing cells was able to replicate in the U937 cells but did not replicate efficiently in U937 cells transduced with the IFNA gene .", "label": " ( protein: IFNA, None) , ( cell line: U937 cells, None) , ( cell line: IFNA -producing cells, None) , ( DNA: IFNA gene, None) , ( protein: IFNA, None) , ( cell line: U937 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFNA, None) , ( cell line: U937 cells, None) , ( cell line: IFNA -producing cells, None) , ( DNA: IFNA gene, None) , ( protein: IFNA, None) , ( cell line: U937 cells, None) " }

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{ "id": "1107", "sentence": "These results suggest that targeting IFN synthesis to HIV-1 -infected cells is an attainable goal and that autocrine IFN synthesis results in a long-lasting and permanent suppression of HIV-1 replication .", "label": " ( protein: IFN, None) , ( protein: IFN, None) , ( cell line: HIV-1 -infected cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN, None) , ( protein: IFN, None) , ( cell line: HIV-1 -infected cells, None) " }

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{ "id": "1108", "sentence": "Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22 .", "label": " ( DNA: KOX zinc finger genes, None) , ( DNA: 7q21-q22, None) , ( DNA: chromosome bands, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: KOX zinc finger genes, None) , ( DNA: 7q21-q22, None) , ( DNA: chromosome bands, None) " }

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{ "id": "1109", "sentence": "Human cDNAs encoding Kruppel-type zinc finger domains , designated KOX 1-32 , have been cloned from human T lymphocyte cell line libraries .", "label": " ( DNA: KOX 1-32, None) , ( DNA: Human cDNAs, None) , ( cell line: human T lymphocyte cell line, None) , ( DNA: human T lymphocyte cell line libraries, None) , ( protein: Kruppel-type zinc finger domains, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: KOX 1-32, None) , ( DNA: Human cDNAs, None) , ( cell line: human T lymphocyte cell line, None) , ( DNA: human T lymphocyte cell line libraries, None) , ( protein: Kruppel-type zinc finger domains, None) " }

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{ "id": "1110", "sentence": "We report here the regional localizations by in situ hybridization of KOX 18 and KOX 25 on chromosome bands 7q21q22 .", "label": " ( DNA: chromosome bands 7q21q22, None) , ( DNA: KOX 25, None) , ( DNA: KOX 18, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: chromosome bands 7q21q22, None) , ( DNA: KOX 25, None) , ( DNA: KOX 18, None) " }

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{ "id": "1111", "sentence": "Pulse-field gel electrophoresis (PFGE) analysis showed that these genes are physically located within a DNA fragment of 250 kb .", "label": " ( DNA: 250 kb, None) , ( DNA: DNA fragment, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: 250 kb, None) , ( DNA: DNA fragment, None) " }

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{ "id": "1112", "sentence": "The genes KOX 4 and KOX 9 , mapped on chromosome 8q24 , were found to be located within a DNA fragment of 450 kb .", "label": " ( DNA: DNA fragment, None) , ( DNA: chromosome 8q24, None) , ( DNA: KOX 4, None) , ( DNA: KOX 9, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: DNA fragment, None) , ( DNA: chromosome 8q24, None) , ( DNA: KOX 4, None) , ( DNA: KOX 9, None) " }

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{ "id": "1113", "sentence": "From the present and previous data, eighteen different KOX genes have been located at least two by two within nine DNA fragments of 200 to 580 kb.", "label": " ( DNA: KOX genes, None) , ( DNA: DNA fragments, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: KOX genes, None) , ( DNA: DNA fragments, None) " }

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{ "id": "1114", "sentence": "Influence of age on the production of Fos and Jun by influenza virus-exposed T cells .", "label": " ( cell type: T cells, None) , ( protein: Fos, None) , ( protein: Jun, None) , ( cell type: influenza virus-exposed T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: Fos, None) , ( protein: Jun, None) , ( cell type: influenza virus-exposed T cells, None) " }

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{ "id": "1115", "sentence": "This study investigated age-related T cell responses after in vitro exposure to influenza A virus .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1116", "sentence": "Mononuclear leukocytes from young or elderly persons were sham-exposed or exposed to influenza virus for 1, 24, and 72 h.", "label": " ( cell type: Mononuclear leukocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: Mononuclear leukocytes, None) " }

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{ "id": "1117", "sentence": "Immunofluorescent staining and flow cytometric analysis were then used to detect T cells producing the transcriptional regulating proteins Fos and Jun .", "label": " ( protein: Fos, None) , ( protein: Jun, None) , ( cell type: T cells, None) , ( protein: transcriptional regulating proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Fos, None) , ( protein: Jun, None) , ( cell type: T cells, None) , ( protein: transcriptional regulating proteins, None) " }

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{ "id": "1118", "sentence": "Fewer virus-exposed cells from elderly donors stained for Fos and Jun at each data point compared with cells from young donors .", "label": " ( protein: Jun, None) , ( protein: Fos, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Jun, None) , ( protein: Fos, None) " }

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{ "id": "1119", "sentence": "Flow cytometric analysis also showed that at 72 h of virus exposure fewer T cells from the elderly produced interferon-gamma ( IFN-gamma ), suggesting a link between the magnitude of the Fos and Jun and IFN-gamma responses.", "label": " ( protein: IFN-gamma, None) , ( protein: Jun, None) , ( protein: interferon-gamma, None) , ( cell type: T cells, None) , ( protein: IFN-gamma, None) , ( protein: Fos, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN-gamma, None) , ( protein: Jun, None) , ( protein: interferon-gamma, None) , ( cell type: T cells, None) , ( protein: IFN-gamma, None) , ( protein: Fos, None) " }

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{ "id": "1120", "sentence": "Thus, failure of virus-exposed T cells to produce Fos and Jun could contribute to the increase in illness due to influenza virus in the elderly .", "label": " ( protein: Fos, None) , ( cell type: T cells, None) , ( cell type: virus-exposed T cells, None) , ( protein: Jun, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Fos, None) , ( cell type: T cells, None) , ( cell type: virus-exposed T cells, None) , ( protein: Jun, None) " }

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{ "id": "1121", "sentence": "The regulation of HIV by retinoic acid correlates with cellular expression of the retinoic acid receptors .", "label": " ( protein: retinoic acid receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: retinoic acid receptors, None) " }

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{ "id": "1122", "sentence": "OBJECTIVES: To analyze the effect of retinoic acids ( RA ) on HIV-1 expression and correlate this effect with expression levels of RA receptors ( RARs ) in T-lymphoid and monocytoid cell lines .", "label": " ( protein: RA receptors, None) , ( protein: RARs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RA receptors, None) , ( protein: RARs, None) " }

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{ "id": "1123", "sentence": "DESIGN AND METHODS: The effect of all-trans and 9-cis RA on HIV-1 production in T-lymphoid ( H9, CEM ) and monocytoid (U937,THP-1) cell lines was measured during acute and chronic infection .", "label": " ( cell line: monocytoid (U937,THP-1) cell lines, None) , ( cell line: T-lymphoid, None) , ( cell line: H9, CEM, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: monocytoid (U937,THP-1) cell lines, None) , ( cell line: T-lymphoid, None) , ( cell line: H9, CEM, None) " }

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{ "id": "1124", "sentence": "The expression levels of human RAR alpha ( hRAR alpha, receptor for all-trans RA ) and the human retinoid-X receptor alpha ( hRXR alpha receptor for 9-cis RA ) were determined by Northern blot analysis.", "label": " ( protein: hRXR alpha receptor, None) , ( protein: hRAR alpha, receptor, None) , ( protein: human RAR alpha, None) , ( protein: human retinoid-X receptor alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hRXR alpha receptor, None) , ( protein: hRAR alpha, receptor, None) , ( protein: human RAR alpha, None) , ( protein: human retinoid-X receptor alpha, None) " }

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{ "id": "1125", "sentence": "RESULTS: Both all-trans and 9-cis RA inhibited virus replication in HIV-1 IIIB-infected monocytoid cells , in the presence and absence of the co-stimulatory agent phorbol myristate acetate ( PMA ).", "label": " ( cell line: HIV-1 IIIB-infected monocytoid cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HIV-1 IIIB-infected monocytoid cells, None) " }

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{ "id": "1126", "sentence": "The retinoids had weak or no stimulatory effects on HIV production by T-cell lines .", "label": " ( cell line: T-cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: T-cell lines, None) " }

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{ "id": "1127", "sentence": "HIV production by PMA -stimulated T-cell lines was inhibited by these retinoids .", "label": " ( cell line: PMA -stimulated T-cell lines, None) , ( cell line: T-cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: PMA -stimulated T-cell lines, None) , ( cell line: T-cell lines, None) " }

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{ "id": "1128", "sentence": "The 9-cis RA was generally more effective than all-trans RA in inhibiting HIV production and in combination generally more effective than the single agents alone.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1129", "sentence": "Human RAR alpha was expressed in H9 , U937 and THP-1 cells , but almost undetectable in CEM cells .", "label": " ( protein: Human RAR alpha, None) , ( cell line: H9, None) , ( cell line: THP-1 cells, None) , ( cell line: CEM cells, None) , ( cell line: U937, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Human RAR alpha, None) , ( cell line: H9, None) , ( cell line: THP-1 cells, None) , ( cell line: CEM cells, None) , ( cell line: U937, None) " }

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{ "id": "1130", "sentence": "Human RXR alpha was significantly expressed in U937 and THP-1 cells , weakly expressed in H9 cells and not detectable in CEM cells .", "label": " ( cell line: H9 cells, None) , ( protein: Human RXR alpha, None) , ( cell line: CEM cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: H9 cells, None) , ( protein: Human RXR alpha, None) , ( cell line: CEM cells, None) " }

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{ "id": "1131", "sentence": "After stimulation by PMA , RXR alpha expression increased in H9 and U937 cells but not in CEM cells .", "label": " ( protein: RXR alpha, None) , ( cell line: U937 cells, None) , ( cell line: H9, None) , ( cell line: CEM cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RXR alpha, None) , ( cell line: U937 cells, None) , ( cell line: H9, None) , ( cell line: CEM cells, None) " }

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{ "id": "1132", "sentence": "Human RAR alpha expression was unchanged in H9 and CEM cells , and elevated in U937 cells , after PMA stimulation.", "label": " ( cell line: H9, None) , ( cell line: CEM cells, None) , ( cell line: U937 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: H9, None) , ( cell line: CEM cells, None) , ( cell line: U937 cells, None) " }

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{ "id": "1133", "sentence": "CONCLUSION: The effect of RA on HIV-1 expression was cell-type-dependent and partially correlated with cellular expression of RARs .", "label": " ( protein: RARs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RARs, None) " }

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{ "id": "1134", "sentence": "Endogenous or exogenously administered RA may have a significant role in HIV regulation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1135", "sentence": "Functions of glutathione and glutathione disulfide in immunology and immunopathology .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1136", "sentence": "Even a moderate increase in the cellular cysteine supply elevates the intracellular glutathione ( GSH ) and glutathione disulfide ( GSSG ) levels and potentiates immunological functions of lymphocytes in vitro.", "label": " ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphocytes, None) " }

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{ "id": "1137", "sentence": "At low GSSG levels , T cells cannot optimally activate the immunologically important transcription factor NF kappa B , whereas high GSSG levels inhibit the DNA binding activity of NF kappa B .", "label": " ( cell type: T cells, None) , ( protein: NF kappa B, None) , ( protein: transcription factor, None) , ( protein: NF kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: NF kappa B, None) , ( protein: transcription factor, None) , ( protein: NF kappa B, None) " }

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{ "id": "1138", "sentence": "The effects of GSSG are antagonized by reduced thioredoxin ( TRX ).", "label": " ( protein: thioredoxin, None) , ( protein: TRX, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: thioredoxin, None) , ( protein: TRX, None) " }

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{ "id": "1139", "sentence": "As the protein tyrosine kinase activities p56lck and p59fyn are activated in intact cells by hydrogen peroxide , they are likely targets for GSSG action .", "label": " ( protein: p59fyn, None) , ( protein: p56lck, None) , ( protein: protein tyrosine kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p59fyn, None) , ( protein: p56lck, None) , ( protein: protein tyrosine kinase, None) " }

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{ "id": "1140", "sentence": "These redox-regulated enzymes trigger signal cascades for NF kappa B activation and transduce signals from the T cell antigen receptor , from CD4 and CD8 molecules , and from the IL-2 receptor beta-chain .", "label": " ( protein: CD4, None) , ( protein: IL-2, None) , ( protein: T cell antigen receptor, None) , ( protein: CD8 molecules, None) , ( protein: redox-regulated enzymes, None) , ( protein: NF kappa B, None) , ( protein: IL-2 receptor beta-chain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD4, None) , ( protein: IL-2, None) , ( protein: T cell antigen receptor, None) , ( protein: CD8 molecules, None) , ( protein: redox-regulated enzymes, None) , ( protein: NF kappa B, None) , ( protein: IL-2 receptor beta-chain, None) " }

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{ "id": "1141", "sentence": "The effector phase of cytotoxic T cell responses and IL-2 -dependent functions are inhibited even by a partial depletion of the intracellular GSH pool .", "label": " ( protein: IL-2, None) , ( cell type: cytotoxic T cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( cell type: cytotoxic T cell, None) " }

[]

{ "id": "1142", "sentence": "As signal transduction is facilitated by prooxidant conditions , we propose that the well-known immunological consequences of GSH depletion ultimately may be results of the accompanying GSSG deficiency .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1143", "sentence": "As HIV -infected patients and SIV-infected rhesus macaques have, on the average, significantly decreased plasma cyst(e)ine and intracellular GSH levels , we also hypothesize that AIDS may be the consequence of a GSSG deficiency as well.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1144", "sentence": "T cells from renal cell carcinoma patients exhibit an abnormal pattern of kappa B-specific DNA-binding activity : a preliminary report.", "label": " ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) " }

[]

{ "id": "1145", "sentence": "Recent data suggest that the poor induction of a T-cell response to human renal cell carcinoma ( RCC ) may be related to alterations in signal transduction pathways .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1146", "sentence": "We report that T cells from RCC patients have two alterations in kappa B motif -specific DNA-binding activity .", "label": " ( cell type: T cells, None) , ( DNA: kappa B motif, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( DNA: kappa B motif, None) " }

[]

{ "id": "1147", "sentence": "The first alteration involves the constitutive expression of substantial kappa B-binding activity in nuclear extracts , which was observed in the electrophoretic mobility shift assay .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1148", "sentence": "The magnitude of kappa B activity in unstimulated patient T cells was similar to that observed in T cells from normal individuals that had been activated in vitro.", "label": " ( cell type: T cells, None) , ( cell type: T cells, None) , ( cell type: unstimulated patient T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( cell type: T cells, None) , ( cell type: unstimulated patient T cells, None) " }

[]

{ "id": "1149", "sentence": "On the basis of Western blotting experiments using antibodies to kappa B/Rel family proteins , the kappa B-binding activity constitutively expressed in T cells from RCC patients is composed mostly of the NF-kappa B1 ( p50 ) subunit .", "label": " ( cell type: T cells, None) , ( protein: kappa B/Rel family proteins, None) , ( protein: p50, None) , ( protein: NF-kappa B1 ( p50 ) subunit, None) , ( protein: antibodies, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: kappa B/Rel family proteins, None) , ( protein: p50, None) , ( protein: NF-kappa B1 ( p50 ) subunit, None) , ( protein: antibodies, None) " }

[]

{ "id": "1150", "sentence": "The second abnormality in kappa B-binding activity in T cells from these patients is that RelA , a member of the Rel homology family which is part of the normal NF-kappa B complex , was not induced in the nucleus following activation.", "label": " ( protein: RelA, None) , ( cell type: T cells, None) , ( protein: NF-kappa B complex, None) , ( protein: Rel homology family, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RelA, None) , ( cell type: T cells, None) , ( protein: NF-kappa B complex, None) , ( protein: Rel homology family, None) " }

[]

{ "id": "1151", "sentence": "Western blotting analysis did not detect any RelA in nuclear extracts either before or after stimulation of T cells .", "label": " ( cell type: T cells, None) , ( protein: RelA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: RelA, None) " }

[]

{ "id": "1152", "sentence": "The altered kappa B-binding activity in T cells from RCC patients may impair their capacity to respond normally to various stimuli.", "label": " ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) " }

[]

{ "id": "1153", "sentence": "Hemoglobin switching in humans is accompanied by changes in the ratio of the transcription factors , GATA-1 and SP1 .", "label": " ( protein: GATA-1, None) , ( protein: Hemoglobin, None) , ( protein: transcription factors, None) , ( protein: SP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA-1, None) , ( protein: Hemoglobin, None) , ( protein: transcription factors, None) , ( protein: SP1, None) " }

[]

{ "id": "1154", "sentence": "BACKGROUND: Understanding the mechanism of developmental regulation of hemoglobin switching has scientific as well as clinical relevance because of the influence of fetal hemoglobin ( HbF ) production in adulthood on the clinical manifestation of thalassemia and sickle cell anemia .", "label": " ( protein: hemoglobin, None) , ( protein: HbF, None) , ( protein: hemoglobin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hemoglobin, None) , ( protein: HbF, None) , ( protein: hemoglobin, None) " }

[]

{ "id": "1155", "sentence": "We have previously found that the normal developmental patterns of globin gene expression are recapitulated in an experimental system of primary cultures that support differentiation of erythroid progenitors .", "label": " ( cell type: erythroid progenitors, None) , ( cell line: primary cultures, None) , ( DNA: globin gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: erythroid progenitors, None) , ( cell line: primary cultures, None) , ( DNA: globin gene, None) " }

[]

{ "id": "1156", "sentence": "We further found that high activities of the transcriptional activators , GATA-1 and SP1 , are associated with normal adult erythroid differentiation .", "label": " ( protein: transcriptional activators, None) , ( protein: SP1, None) , ( protein: GATA-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcriptional activators, None) , ( protein: SP1, None) , ( protein: GATA-1, None) " }

[]

{ "id": "1157", "sentence": "MATERIALS AND METHODS: In the present work, we have studied, the activities of GATA-1 and SP1 during differentiation of cultured erythroid progenitors derived from cord blood and from fetal livers , as well as from beta zero- thalassemia patients .", "label": " ( cell type: erythroid progenitors, None) , ( protein: SP1, None) , ( protein: GATA-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: erythroid progenitors, None) , ( protein: SP1, None) , ( protein: GATA-1, None) " }

[]

{ "id": "1158", "sentence": "RESULTS: The results showed high GATA-1 binding activity and very low SP1 activity in the fetal liver cultures .", "label": " ( protein: SP1, None) , ( cell line: fetal liver cultures, None) , ( protein: GATA-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: SP1, None) , ( cell line: fetal liver cultures, None) , ( protein: GATA-1, None) " }

[]

{ "id": "1159", "sentence": "This pattern was in contrast to cultures derived from normal adult peripheral blood , in which both GATA-1 and SP1 activities were high.", "label": " ( protein: GATA-1, None) , ( protein: SP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA-1, None) , ( protein: SP1, None) " }

[]

{ "id": "1160", "sentence": "Cord blood cultures showed an additive combination of \"adult\" and \"fetal\" patterns.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1161", "sentence": "The progenitors derived from a beta zero- thalassemia patient with high HbF production showed \"fetal\" pattern.", "label": " ( protein: HbF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HbF, None) " }

[]

{ "id": "1162", "sentence": "On the other hand, in cultures of 2 beta zero- thalassemia patients without high HbF , \"adult\" pattern was observed.", "label": " ( protein: HbF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HbF, None) " }

[]

{ "id": "1163", "sentence": "CONCLUSIONS: In the present work, we show that human fetal and adult erythroid progenitors are distinct in their transcription factors , and that the commitment to fetal or adult program occurs at a very early differentiation stage.", "label": " ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) " }

[]

{ "id": "1164", "sentence": "Our studies also demonstrate that under anemic stress , recruitment of fetal progenitors may occur in adulthood .", "label": " ( cell type: fetal progenitors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: fetal progenitors, None) " }

[]

{ "id": "1165", "sentence": "Transcription-independent turnover of I kappa B alpha during monocyte adherence : implications for a translational component regulating I kappa B alpha /MAD-3 mRNA levels .", "label": " ( protein: /MAD-3, None) , ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: /MAD-3, None) , ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) " }

[]

{ "id": "1166", "sentence": "We identified I kappa B alpha /MAD-3 as an immediate-early gene in human monocytes that is expressed in response to a variety of signals, including adhesion , lipopolysaccharide , and phorbol myristate acetate .", "label": " ( DNA: immediate-early gene, None) , ( protein: I kappa B alpha, None) , ( cell type: human monocytes, None) , ( protein: I kappa B alpha /MAD-3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: immediate-early gene, None) , ( protein: I kappa B alpha, None) , ( cell type: human monocytes, None) , ( protein: I kappa B alpha /MAD-3, None) " }

[]

{ "id": "1167", "sentence": "Within 5 min of monocyte adhesion , the level of the I kappa B alpha protein is markedly diminished but is rapidly replaced in a cycloheximide-sensitive manner within 20 min.", "label": " ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha protein, None) " }

[]

{ "id": "1168", "sentence": "Accompanying the rapid turnover of the I kappa B alpha protein is simultaneous translocation of NF-kappa B-related transcription factors to nuclei of adhered monocytes.", "label": " ( protein: transcription factors, None) , ( protein: I kappa B alpha protein, None) , ( protein: NF-kappa B-related transcription factors, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) , ( protein: I kappa B alpha protein, None) , ( protein: NF-kappa B-related transcription factors, None) , ( protein: I kappa B alpha, None) " }

[]

{ "id": "1169", "sentence": "The demonstration that NF-kappa B can regulate I kappa B alpha /MAD-3 gene transcription in other cell types suggested that the rapid increase in steady-state I kappa B alpha /MAD-3 mRNA levels we observed within 30 min of monocyte adherence would result from NF-kappa B -dependent transcriptional stimulation of the I kappa B alpha /MAD-3 gene .", "label": " ( protein: NF-kappa B, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) , ( DNA: I kappa B alpha /MAD-3 gene, None) , ( protein: NF-kappa B, None) , ( DNA: I kappa B alpha /MAD-3 gene, None) , ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) , ( DNA: I kappa B alpha /MAD-3 gene, None) , ( protein: NF-kappa B, None) , ( DNA: I kappa B alpha /MAD-3 gene, None) , ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha, None) " }

[]

{ "id": "1170", "sentence": "Nuclear run-on analyses indicated that, instead, while several immediate-early cytokine genes , such as the interleukin 1 beta ( IL-1 beta ) gene , were transcriptionally activated during monocyte adhesion , the rate of I kappa B alpha /MAD-3 gene transcription remained constant.", "label": " ( DNA: interleukin 1 beta ( IL-1 beta ) gene, None) , ( protein: IL-1 beta, None) , ( DNA: I kappa B alpha /MAD-3 gene, None) , ( protein: interleukin 1 beta, None) , ( protein: I kappa B alpha, None) , ( DNA: immediate-early cytokine genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: interleukin 1 beta ( IL-1 beta ) gene, None) , ( protein: IL-1 beta, None) , ( DNA: I kappa B alpha /MAD-3 gene, None) , ( protein: interleukin 1 beta, None) , ( protein: I kappa B alpha, None) , ( DNA: immediate-early cytokine genes, None) " }

[]

{ "id": "1171", "sentence": "The adherence-dependent increase in I kappa B alpha /MAD-3 mRNA levels was also not a consequence of mRNA stabilization events .", "label": " ( RNA: mRNA, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: mRNA, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) , ( protein: I kappa B alpha, None) " }

[]

{ "id": "1172", "sentence": "Interestingly, while increases in both IL-1 beta and I kappa B alpha/MAD-3 mRNA levels were detected in nuclei of adherent monocytes , cytoplasmic levels of IL-1 beta mRNA increased during adherence whereas those of I kappa B alpha /MAD-3 mRNA did not.", "label": " ( cell type: adherent monocytes, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) , ( protein: I kappa B alpha, None) , ( RNA: IL-1 beta mRNA, None) , ( protein: IL-1 beta, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: adherent monocytes, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) , ( protein: I kappa B alpha, None) , ( RNA: IL-1 beta mRNA, None) , ( protein: IL-1 beta, None) " }

[]

{ "id": "1173", "sentence": "Taken together, our data suggest that two interactive mechanisms regulate monocytic I kappa B alpha /MAD-3 mRNA levels .", "label": " ( protein: I kappa B alpha, None) , ( RNA: monocytic I kappa B alpha /MAD-3 mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I kappa B alpha, None) , ( RNA: monocytic I kappa B alpha /MAD-3 mRNA, None) " }

[]

{ "id": "1174", "sentence": "We propose that adherent monocytes regulate nuclear processing (or decay) of I kappa B alpha /MAD-3 mRNA , thereby increasing mRNA levels without stimulating I kappa B alpha /MAD-3 gene transcription .", "label": " ( cell type: adherent monocytes, None) , ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) , ( DNA: I kappa B alpha /MAD-3 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: adherent monocytes, None) , ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) , ( DNA: I kappa B alpha /MAD-3 gene, None) " }

[]

{ "id": "1175", "sentence": "Moreover, since inhibition of protein synthesis leads to accumulation of I kappa B alpha /MAD-3 mRNA without stimulating I kappa B alpha /MAD-3 gene transcription , we suggest that low cytoplasmic levels of I kappa B alpha /MAD-3 mRNA are maintained by a translation-dependent degradation mechanism .", "label": " ( DNA: I kappa B alpha /MAD-3 gene, None) , ( protein: I kappa B alpha, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) , ( protein: I kappa B alpha, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: I kappa B alpha /MAD-3 gene, None) , ( protein: I kappa B alpha, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) , ( protein: I kappa B alpha, None) , ( RNA: I kappa B alpha /MAD-3 mRNA, None) , ( protein: I kappa B alpha, None) " }

[]

{ "id": "1176", "sentence": "Distinct roles of the molecular chaperone hsp90 in modulating dioxin receptor function via the basic helix-loop-helix and PAS domains .", "label": " ( protein: chaperone hsp90, None) , ( protein: helix-loop-helix, None) , ( protein: PAS domains, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: chaperone hsp90, None) , ( protein: helix-loop-helix, None) , ( protein: PAS domains, None) " }

[]

{ "id": "1177", "sentence": "The intracellular dioxin receptor mediates signal transduction by dioxin and functions as a ligand-activated transcription factor .", "label": " ( protein: ligand-activated transcription factor, None) , ( protein: intracellular dioxin receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ligand-activated transcription factor, None) , ( protein: intracellular dioxin receptor, None) " }

[]

{ "id": "1178", "sentence": "It contains a basic helix-loop-helix ( bHLH ) motif contiguous with a Per-Arnt-Sim (PAS) homology region .", "label": " ( protein: basic helix-loop-helix ( bHLH ) motif, None) , ( protein: bHLH, None) , ( protein: Per-Arnt-Sim (PAS) homology region, None) , ( protein: helix-loop-helix, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: basic helix-loop-helix ( bHLH ) motif, None) , ( protein: bHLH, None) , ( protein: Per-Arnt-Sim (PAS) homology region, None) , ( protein: helix-loop-helix, None) " }

[]

{ "id": "1179", "sentence": "In extracts from nonstimulated cells the receptor is recovered in an inducible cytoplasmic form associated with the 90-kDa heat shock protein ( hsp90 ), a molecular chaperone .", "label": " ( protein: hsp90, None) , ( protein: 90-kDa heat shock protein, None) , ( protein: molecular chaperone, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hsp90, None) , ( protein: 90-kDa heat shock protein, None) , ( protein: molecular chaperone, None) " }

[]

{ "id": "1180", "sentence": "We have reconstituted ligand-dependent activation of the receptor to a DNA-binding form by using the dioxin receptor and its bHLH-PAS partner factor Arnt expressed by in vitro translation in reticulocyte lysate.", "label": " ( protein: DNA-binding form, None) , ( protein: bHLH-PAS partner factor, None) , ( protein: dioxin receptor, None) , ( protein: Arnt, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNA-binding form, None) , ( protein: bHLH-PAS partner factor, None) , ( protein: dioxin receptor, None) , ( protein: Arnt, None) " }

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{ "id": "1181", "sentence": "Deletion of the PAS domain of the receptor resulted in constitutive dimerization with Arnt .", "label": " ( protein: PAS domain, None) , ( protein: Arnt, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PAS domain, None) , ( protein: Arnt, None) " }

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{ "id": "1182", "sentence": "In contrast, this receptor mutant showed low levels of xenobiotic response element-binding activity , indicating that the PAS domain may be important for DNA-binding affinity and/or specificity of the receptor.", "label": " ( protein: PAS domain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PAS domain, None) " }

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{ "id": "1183", "sentence": "It was not possible to reconstitute dioxin receptor function with proteins expressed in wheat germ lysate .", "label": " ( protein: dioxin receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: dioxin receptor, None) " }

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{ "id": "1184", "sentence": "In line with these observations, reticulocyte lysate but not wheat germ lysate promoted the association of de novo synthesized dioxin receptor with hsp90 .", "label": " ( protein: hsp90, None) , ( protein: dioxin receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hsp90, None) , ( protein: dioxin receptor, None) " }

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{ "id": "1185", "sentence": "At least two distinct domains of the receptor mediated interaction with hsp90 : the ligand-binding domain located within the PAS region and, surprisingly, the bHLH domain .", "label": " ( protein: bHLH domain, None) , ( protein: PAS region, None) , ( protein: ligand-binding domain, None) , ( protein: hsp90, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: bHLH domain, None) , ( protein: PAS region, None) , ( protein: ligand-binding domain, None) , ( protein: hsp90, None) " }

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{ "id": "1186", "sentence": "Whereas ligand-binding activity correlated with association with hsp90 , bHLH- hsp90 interaction appeared to be important for DNA-binding activity but not for dimerization of the receptor.", "label": " ( protein: hsp90, None) , ( protein: hsp90, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hsp90, None) , ( protein: hsp90, None) " }

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{ "id": "1187", "sentence": "Several distinct roles for hsp90 in modulating dioxin receptor function are therefore likely: correct folding of the ligand-binding domain, interference with Arnt heterodimerization, and folding of a DNA-binding conformation of the bHLH domain .", "label": " ( protein: hsp90, None) , ( protein: bHLH domain, None) , ( protein: dioxin receptor, None) , ( protein: Arnt, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hsp90, None) , ( protein: bHLH domain, None) , ( protein: dioxin receptor, None) , ( protein: Arnt, None) " }

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{ "id": "1188", "sentence": "Thus, the dioxin receptor system provides a complex and interesting model of the regulation of transcription factors by hsp90 .", "label": " ( protein: dioxin receptor, None) , ( protein: hsp90, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: dioxin receptor, None) , ( protein: hsp90, None) , ( protein: transcription factors, None) " }

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{ "id": "1189", "sentence": "Induction of transcription factors in human T lymphocytes by aspirin -like drugs .", "label": " ( protein: transcription factors, None) , ( cell type: human T lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) , ( cell type: human T lymphocytes, None) " }

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{ "id": "1190", "sentence": "Aspirin-like drugs ( ALD ) induce calcium mobilization , an essential component of T cell activation , but do not induce the biosynthesis of IL-2 .", "label": " ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) " }

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{ "id": "1191", "sentence": "To understand the extent to which ALD may mimic mitogenic stimulation , we studied cytoplasmic and nuclear signaling steps in ALD -treated T cells .", "label": " ( cell line: ALD -treated T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: ALD -treated T cells, None) " }

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{ "id": "1192", "sentence": "We found that ALD induce a transient activation of protein kinase ( PKC ) but have no effect (in comparison to anti-CD3 antibodies ) on protein tyrosine phosphorylation nor on PCL gamma 1 tyrosine phosphorylation .", "label": " ( protein: PKC, None) , ( protein: protein kinase, None) , ( protein: anti-CD3 antibodies, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC, None) , ( protein: protein kinase, None) , ( protein: anti-CD3 antibodies, None) " }

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{ "id": "1193", "sentence": "ALD -induced calcium mobilization and PKC activation are independent of tyrosine protein kinase activity as shown by the lack of effect of herbimycin , a tyrosine -protein kinase -specific inhibitor .", "label": " ( protein: tyrosine -protein kinase, None) , ( protein: PKC, None) , ( protein: tyrosine protein kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tyrosine -protein kinase, None) , ( protein: PKC, None) , ( protein: tyrosine protein kinase, None) " }

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{ "id": "1194", "sentence": "Although we detected no IL-2 mRNA in ALD -treated cells , the nuclei of these cells contain proteins capable of binding to three regulatory sequences in the IL-2 promoter region : NFAT , NF kappa B , and AP-1 .", "label": " ( DNA: IL-2 promoter region, None) , ( protein: NF kappa B, None) , ( cell line: ALD -treated cells, None) , ( protein: NFAT, None) , ( protein: IL-2, None) , ( DNA: regulatory sequences, None) , ( protein: AP-1, None) , ( protein: IL-2, None) , ( RNA: IL-2 mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IL-2 promoter region, None) , ( protein: NF kappa B, None) , ( cell line: ALD -treated cells, None) , ( protein: NFAT, None) , ( protein: IL-2, None) , ( DNA: regulatory sequences, None) , ( protein: AP-1, None) , ( protein: IL-2, None) , ( RNA: IL-2 mRNA, None) " }

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{ "id": "1195", "sentence": "These binding activities are expressed only in activated T cells .", "label": " ( cell type: activated T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: activated T cells, None) " }

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{ "id": "1196", "sentence": "The expression of AP-1 depended on calcium mobilization and PKC activation .", "label": " ( protein: AP-1, None) , ( protein: PKC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( protein: PKC, None) " }

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{ "id": "1197", "sentence": "These data suggest that ALD cause transient but significant changes in T cell transmembrane signaling , although some events induced by stimulation with anti-CD3 antibodies are not induced by ALD .", "label": " ( protein: anti-CD3 antibodies, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti-CD3 antibodies, None) " }

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{ "id": "1198", "sentence": "The signal is transmitted to the nucleus and induces DNA-binding activity by several transcription factors .", "label": " ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) " }

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{ "id": "1199", "sentence": "However, the ALD stimulus is not capable of causing complete T cell activation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }