Datasets:

huy-nh-2000

/

instructUIE

like 0

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{ "id": "3100", "sentence": "The negative effects of point mutations in the LMP1 (1-231) core TRAF binding motif on TRAF binding and NF-kappaB activation genetically link the TRAFs to LMP1 (1-231)-mediated NF-kappaB activation .", "label": " ( protein: NF-kappaB, None) , ( protein: LMP1, None) , ( protein: TRAFs, None) , ( protein: NF-kappaB, None) , ( DNA: LMP1 (1-231) core TRAF binding motif, None) , ( protein: LMP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappaB, None) , ( protein: LMP1, None) , ( protein: TRAFs, None) , ( protein: NF-kappaB, None) , ( DNA: LMP1 (1-231) core TRAF binding motif, None) , ( protein: LMP1, None) " }

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{ "id": "3101", "sentence": "NF-kappaB activation by LMP1 (1-231) is likely to be mediated by TRAF1 /TRAF2 heteroaggregates since TRAF1 is unique among the TRAFs in coactivating NF-kappaB with LMP1 (1-231), a TRAF2 dominant-negative mutant can block LMP1 (1-231)-mediated NF-kappaB activation as well as TRAF1 coactivation , and 30% of TRAF2 is associated with TRAF1 in EBV-transformed B cells.", "label": " ( protein: NF-kappaB, None) , ( protein: NF-kappaB, None) , ( protein: TRAF2, None) , ( protein: TRAF1, None) , ( protein: LMP1, None) , ( protein: TRAF1, None) , ( protein: TRAF1, None) , ( protein: /TRAF2, None) , ( protein: TRAFs, None) , ( protein: LMP1, None) , ( protein: LMP1, None) , ( protein: TRAF1, None) , ( protein: NF-kappaB, None) , ( protein: TRAF2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappaB, None) , ( protein: NF-kappaB, None) , ( protein: TRAF2, None) , ( protein: TRAF1, None) , ( protein: LMP1, None) , ( protein: TRAF1, None) , ( protein: TRAF1, None) , ( protein: /TRAF2, None) , ( protein: TRAFs, None) , ( protein: LMP1, None) , ( protein: LMP1, None) , ( protein: TRAF1, None) , ( protein: NF-kappaB, None) , ( protein: TRAF2, None) " }

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{ "id": "3102", "sentence": "TRAF3 is a negative modulator of LMP1 (1-231)-mediated NF-kappaB activation .", "label": " ( protein: LMP1, None) , ( protein: TRAF3, None) , ( protein: NF-kappaB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LMP1, None) , ( protein: TRAF3, None) , ( protein: NF-kappaB, None) " }

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{ "id": "3103", "sentence": "Surprisingly, TRAF 1 , -2 , or -3 does not interact with the terminal LMP1 CT aa 333 to 386 which can independently mediate NF-kappaB activation .", "label": " ( protein: LMP1, None) , ( protein: NF-kappaB, None) , ( protein: terminal LMP1 CT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LMP1, None) , ( protein: NF-kappaB, None) , ( protein: terminal LMP1 CT, None) " }

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{ "id": "3104", "sentence": "The constitutive association of TRAFs with LMP1 through the aa 187 to 231 domain which is important in NF-kappaB activation and primary B-lymphocyte growth transformation implicates TRAF aggregation in LMP1 signaling .", "label": " ( protein: TRAFs, None) , ( protein: LMP1, None) , ( cell type: B-lymphocyte, None) , ( protein: TRAF, None) , ( protein: aa 187 to 231 domain, None) , ( protein: NF-kappaB, None) , ( protein: LMP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TRAFs, None) , ( protein: LMP1, None) , ( cell type: B-lymphocyte, None) , ( protein: TRAF, None) , ( protein: aa 187 to 231 domain, None) , ( protein: NF-kappaB, None) , ( protein: LMP1, None) " }

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{ "id": "3105", "sentence": "Lack of IL-12 signaling in human allergen-specific Th2 cells .", "label": " ( cell line: human allergen-specific Th2 cells, None) , ( protein: IL-12, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: human allergen-specific Th2 cells, None) , ( protein: IL-12, None) " }

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{ "id": "3106", "sentence": "IL-12 is a powerful skewer of CD4+ T cell responses toward the Th1 phenotype by inducing IFN-gamma production in naive Th cells .", "label": " ( cell line: naive Th cells, None) , ( protein: IFN-gamma, None) , ( protein: IL-12, None) , ( cell type: CD4+ T cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: naive Th cells, None) , ( protein: IFN-gamma, None) , ( protein: IL-12, None) , ( cell type: CD4+ T cell, None) " }

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{ "id": "3107", "sentence": "In the present study we addressed the question of whether IL-12 can reverse established Th2 responses into Th1/Th0 responses by inducing IFN-gamma production in memory Th2 cells .", "label": " ( protein: IL-12, None) , ( cell line: memory Th2 cells, None) , ( protein: IFN-gamma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-12, None) , ( cell line: memory Th2 cells, None) , ( protein: IFN-gamma, None) " }

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{ "id": "3108", "sentence": "To this aim, allergen-specific CD4+ T cell clones ( TCC ) were generated from the peripheral blood of three atopic patients , and their cytokine profiles were analyzed.", "label": " ( cell line: TCC, None) , ( cell line: allergen-specific CD4+ T cell clones, None) , ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: TCC, None) , ( cell line: allergen-specific CD4+ T cell clones, None) , ( protein: cytokine, None) " }

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{ "id": "3109", "sentence": "The majority of these TCC exhibited a strongly polarized Th2 cytokine profile , and the production of IFN-gamma could not be induced by exogenous IL-12 .", "label": " ( cell line: TCC, None) , ( protein: cytokine, None) , ( protein: IFN-gamma, None) , ( protein: IL-12, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: TCC, None) , ( protein: cytokine, None) , ( protein: IFN-gamma, None) , ( protein: IL-12, None) " }

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{ "id": "3110", "sentence": "Only those TCC with low IFN-gamma levels in the absence of IL-12 responded to IL-12 by additional enhancement of IFN-gamma production .", "label": " ( protein: IFN-gamma, None) , ( protein: IFN-gamma, None) , ( cell line: TCC, None) , ( protein: IL-12, None) , ( protein: IL-12, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN-gamma, None) , ( protein: IFN-gamma, None) , ( cell line: TCC, None) , ( protein: IL-12, None) , ( protein: IL-12, None) " }

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{ "id": "3111", "sentence": "The IL-12 nonresponsiveness of the Th2 clones was further evident by the total lack of IL-12 -induced phosphorylation of STAT4 ( signal transducer and activator of transcription-4 ), a transcription factor that is typically involved in IL-12 signaling .", "label": " ( protein: STAT4, None) , ( protein: IL-12, None) , ( protein: IL-12, None) , ( cell line: Th2 clones, None) , ( protein: IL-12, None) , ( protein: transcription factor, None) , ( protein: signal transducer and activator of transcription-4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: STAT4, None) , ( protein: IL-12, None) , ( protein: IL-12, None) , ( cell line: Th2 clones, None) , ( protein: IL-12, None) , ( protein: transcription factor, None) , ( protein: signal transducer and activator of transcription-4, None) " }

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{ "id": "3112", "sentence": "Consequently, IL-12 also failed to induce the DNA-binding activity of STAT4 -containing complexes in the nuclei of these Th2 clones .", "label": " ( protein: STAT4 -containing complexes, None) , ( protein: STAT4, None) , ( protein: IL-12, None) , ( cell line: Th2 clones, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: STAT4 -containing complexes, None) , ( protein: STAT4, None) , ( protein: IL-12, None) , ( cell line: Th2 clones, None) " }

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{ "id": "3113", "sentence": "All TCC expressed equal levels of the low-affinity IL-12R beta1 subunit .", "label": " ( protein: IL-12R, None) , ( cell line: TCC, None) , ( protein: low-affinity IL-12R beta1 subunit, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-12R, None) , ( cell line: TCC, None) , ( protein: low-affinity IL-12R beta1 subunit, None) " }

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{ "id": "3114", "sentence": "Our results indicate that human allergen-specific Th cells with strongly polarized Th2 cytokine profiles do not respond to IL-12 and, therefore, cannot be induced to produce IFN-gamma .", "label": " ( protein: IL-12, None) , ( protein: IFN-gamma, None) , ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-12, None) , ( protein: IFN-gamma, None) , ( protein: cytokine, None) " }

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{ "id": "3115", "sentence": "The apparent high frequency of IL-12 -nonresponsive Th cells within the allergen-specific populations in atopic patients predicts a limited skewing potential of IL-12 in the case of established Th2 responses , but only affecting newly recruited naive Th cells .", "label": " ( cell line: IL-12 -nonresponsive Th cells, None) , ( protein: IL-12, None) , ( cell line: Th cells, None) , ( protein: IL-12, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: IL-12 -nonresponsive Th cells, None) , ( protein: IL-12, None) , ( cell line: Th cells, None) , ( protein: IL-12, None) " }

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{ "id": "3116", "sentence": "Cloning and expression of the Epstein-Barr virus -encoded dUTPase : patients with acute, reactivated or chronic virus infection develop antibodies against the enzyme .", "label": " ( protein: antibodies, None) , ( protein: enzyme, None) , ( protein: Epstein-Barr virus -encoded dUTPase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: antibodies, None) , ( protein: enzyme, None) , ( protein: Epstein-Barr virus -encoded dUTPase, None) " }

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{ "id": "3117", "sentence": "The gene encoding the Epstein-Barr virus ( EBV )-specific dUTPase was amplified from virus DNA by PCR .", "label": " ( DNA: virus DNA, None) , ( protein: Epstein-Barr virus ( EBV )-specific dUTPase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: virus DNA, None) , ( protein: Epstein-Barr virus ( EBV )-specific dUTPase, None) " }

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{ "id": "3118", "sentence": "The active enzyme was expressed in Escherichia coli and in insect cells as a non-fusion protein .", "label": " ( protein: non-fusion protein, None) , ( cell type: insect cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: non-fusion protein, None) , ( cell type: insect cells, None) " }

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{ "id": "3119", "sentence": "The protein from E. coli specifically converted dUTP to dUMP and did not react with other dNTPs or NTPs .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3120", "sentence": "Preliminary experiments yielded a Km value of about 0.8 microM for dUTP .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3121", "sentence": "MAbs against the dUTPase reacted with a protein of approximately 31 kDa in 12-O-tetradecanoyl-phorbol-13-acetate ( TPA )-stimulated B cells harbouring either type 1 or type 2 EBV .", "label": " ( cell line: 12-O-tetradecanoyl-phorbol-13-acetate ( TPA )-stimulated B cells, None) , ( protein: dUTPase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: 12-O-tetradecanoyl-phorbol-13-acetate ( TPA )-stimulated B cells, None) , ( protein: dUTPase, None) " }

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{ "id": "3122", "sentence": "The protein was found in untreated cells at low levels, whereas induction of the lytic replication cycle by TPA treatment or by providing the immediate early transactivator BZLF1 in trans resulted in increased expression .", "label": " ( protein: immediate early transactivator, None) , ( cell type: untreated cells, None) , ( protein: BZLF1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: immediate early transactivator, None) , ( cell type: untreated cells, None) , ( protein: BZLF1, None) " }

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{ "id": "3123", "sentence": "We demonstrated that the virus dUTPase isolated from EBV -infected cells is a phosphoprotein .", "label": " ( protein: phosphoprotein, None) , ( cell type: EBV -infected cells, None) , ( protein: virus dUTPase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: phosphoprotein, None) , ( cell type: EBV -infected cells, None) , ( protein: virus dUTPase, None) " }

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{ "id": "3124", "sentence": "The protein expressed in insect cells was used to test for the presence of specific antibodies in sera from normal, healthy carriers and from patients with various diseases.", "label": " ( protein: specific antibodies, None) , ( cell type: insect cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: specific antibodies, None) , ( cell type: insect cells, None) " }

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{ "id": "3125", "sentence": "While the sera of EBV -negative individuals (0/3) or healthy carriers (0/33) did not contain detectable levels of antibodies, patients with mononucleosis (5/18), chronic EBV infection (2/7), EBV reactivation (7/20) and human immunodeficiency virus infection (5/24) showed elevated antibody titres against the enzyme.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3126", "sentence": "This indicated that the dUTPase is expressed during EBV replication and reactivation.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3127", "sentence": "The enzyme might therefore be a potential target for drug therapy under conditions of active DNA replication .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3128", "sentence": "The catalytic domain of pp56(lck) , but not its regulatory domain , is sufficient for inducing IL-2 production .", "label": " ( protein: IL-2, None) , ( protein: catalytic domain, None) , ( protein: pp56(lck), None) , ( protein: regulatory domain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( protein: catalytic domain, None) , ( protein: pp56(lck), None) , ( protein: regulatory domain, None) " }

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{ "id": "3129", "sentence": "The lymphoid src kinase pp56(lck) has been shown to be essential for the induction of different T lymphocyte responses , including CD4 -mediated enhancement of Ag-induced T cell activation , early T cell differentiation , induction of IL-2 production , and cytotoxicity .", "label": " ( protein: IL-2, None) , ( cell type: T lymphocyte, None) , ( protein: lymphoid src kinase, None) , ( protein: pp56(lck), None) , ( protein: CD4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( cell type: T lymphocyte, None) , ( protein: lymphoid src kinase, None) , ( protein: pp56(lck), None) , ( protein: CD4, None) " }

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{ "id": "3130", "sentence": "It is assumed that pp56(lck) acts on these processes by phosphorylating substrates.", "label": " ( protein: pp56(lck), None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: pp56(lck), None) " }

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{ "id": "3131", "sentence": "However, it has been recently reported that the NH2 regulatory domain is sufficient to mediate CD4 accessory function .", "label": " ( protein: CD4, None) , ( protein: regulatory domain, None) , ( protein: NH2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD4, None) , ( protein: regulatory domain, None) , ( protein: NH2, None) " }

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{ "id": "3132", "sentence": "In this report we address the contribution of the regulatory and catalytic domains of pp56(lck) to another function of this enzyme independent of CD4 : TCR-induced IL-2 production .", "label": " ( protein: pp56(lck), None) , ( protein: CD4, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: pp56(lck), None) , ( protein: CD4, None) , ( protein: IL-2, None) " }

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{ "id": "3133", "sentence": "Two pp56(lck) mutants lacking either the entire catalytic domain or the entire NH2 regulatory domain were generated, and their abilities to trigger transactivation of the TCR-regulated nuclear factor of activated T cells ( NF-AT ) region of the IL-2 promoter were compared.", "label": " ( protein: NH2, None) , ( protein: pp56(lck), None) , ( DNA: TCR-regulated nuclear factor of activated T cells ( NF-AT ) region, None) , ( DNA: IL-2 promoter, None) , ( protein: TCR-regulated nuclear factor, None) , ( protein: catalytic domain, None) , ( protein: NF-AT, None) , ( protein: pp56(lck) mutants, None) , ( cell type: activated T cells, None) , ( protein: regulatory domain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NH2, None) , ( protein: pp56(lck), None) , ( DNA: TCR-regulated nuclear factor of activated T cells ( NF-AT ) region, None) , ( DNA: IL-2 promoter, None) , ( protein: TCR-regulated nuclear factor, None) , ( protein: catalytic domain, None) , ( protein: NF-AT, None) , ( protein: pp56(lck) mutants, None) , ( cell type: activated T cells, None) , ( protein: regulatory domain, None) " }

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{ "id": "3134", "sentence": "Only the catalytic, but not the NH2 regulatory, domain of pp56(lck) was able to induce NF-AT region transactivation on its own and to cooperate with other intracellular signals to trigger this response.", "label": " ( protein: NF-AT, None) , ( protein: pp56(lck), None) , ( protein: NH2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT, None) , ( protein: pp56(lck), None) , ( protein: NH2, None) " }

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{ "id": "3135", "sentence": "Moreover, the catalytic domain of pp56(lck) was able to induce IL-2 cytokine production to an extent similar to that of wild-type pp56(lck) .", "label": " ( protein: catalytic domain, None) , ( protein: pp56(lck), None) , ( protein: IL-2, None) , ( protein: cytokine, None) , ( protein: pp56(lck), None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: catalytic domain, None) , ( protein: pp56(lck), None) , ( protein: IL-2, None) , ( protein: cytokine, None) , ( protein: pp56(lck), None) " }

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{ "id": "3136", "sentence": "We conclude that different domains of the pp56(lck) molecule contribute to regulate distinct biologic functions .", "label": " ( protein: pp56(lck), None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: pp56(lck), None) " }

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{ "id": "3137", "sentence": "In fact, while the NH2 regulatory domain is sufficient to mediate CD4 accessory function, we show here that the catalytic domain of pp56(lck) is sufficient for induction of IL-2 production , mimicking TCR ligation .", "label": " ( protein: IL-2, None) , ( protein: TCR, None) , ( protein: catalytic domain, None) , ( protein: regulatory domain, None) , ( protein: CD4, None) , ( protein: pp56(lck), None) , ( protein: NH2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( protein: TCR, None) , ( protein: catalytic domain, None) , ( protein: regulatory domain, None) , ( protein: CD4, None) , ( protein: pp56(lck), None) , ( protein: NH2, None) " }

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{ "id": "3138", "sentence": "[The changes in glucocorticoid receptors in peripheral leukocytes in asthmatic subjects ]", "label": " ( cell type: peripheral leukocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral leukocytes, None) " }

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{ "id": "3139", "sentence": "The number of glucocorticoid receptors ( GCR ) in peripheral leukocytes was determined by radioligand-binding assay in extrinsic and intrinsic asthmatics .", "label": " ( cell type: peripheral leukocytes, None) , ( protein: GCR, None) , ( protein: glucocorticoid receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral leukocytes, None) , ( protein: GCR, None) , ( protein: glucocorticoid receptors, None) " }

[]

{ "id": "3140", "sentence": "Their corresponding plasma cortisol levels were assessed.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3141", "sentence": "The results showed that the average number of GCR in asthmatics was significantly lower than that in healthy subjects (P < 0.01), and there was a linear correlation between the number of GCR and the course of asthma .", "label": " ( protein: GCR, None) , ( protein: GCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCR, None) , ( protein: GCR, None) " }

[]

{ "id": "3142", "sentence": "Besides, there was also a linear correlation between the number of GCR and the age of the initial attack of asthma .", "label": " ( protein: GCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCR, None) " }

[]

{ "id": "3143", "sentence": "No difference in plasma cortisol level was found between asthmatics and healthy subjects .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3144", "sentence": "These findings suggest that there is no primary and general impairment of glucocorticoid metabolism in the asthmatics , but the number of GCR in the asthmatics is lower than that in healthy controls.", "label": " ( protein: GCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCR, None) " }

[]

{ "id": "3145", "sentence": "The decrease of the number of GCR in asthmatics , we think, is related to heredity and repeated attacks of asthma .", "label": " ( protein: GCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCR, None) " }

[]

{ "id": "3146", "sentence": "Novel aldosterone receptors : specificity-conferring mechanism at the level of the cell membrane .", "label": " ( protein: aldosterone receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: aldosterone receptors, None) " }

[]

{ "id": "3147", "sentence": "Functional studies in extra-renal, nonepithelial cells such as smooth muscle cells and more recently circulating human lymphocytes have provided increasing evidence that aldosterone produces not only classical genomic effects, but also rapid non-genomic effects on transmembrane electrolyte movements .", "label": " ( cell type: extra-renal, nonepithelial cells, None) , ( cell type: smooth muscle cells, None) , ( cell type: human lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: extra-renal, nonepithelial cells, None) , ( cell type: smooth muscle cells, None) , ( cell type: human lymphocytes, None) " }

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{ "id": "3148", "sentence": "These involve activation of the sodium/proton-exchanger of the cell membrane at very low, physiological concentrations of aldosterone with an acute onset within 1-2 minutes.", "label": " ( protein: sodium/proton-exchanger, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: sodium/proton-exchanger, None) " }

[]

{ "id": "3149", "sentence": "A second messenger cascade involved is the inositol-1,4,5-trisphosphate /calcium pathway which responds over the same rapid time course.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3150", "sentence": "Such changes clearly cannot be explained by genomic mechanisms , which are responsible for later effects than the membrane-related rapid responses .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3151", "sentence": "In addition to its rapid time course the unique characteristics of this new pathway for steroid action include a 10000-fold selectivity for aldosterone over cortisol and the ineffectiveness of spironolactones , classical mineralocorticoid antagonists , as antagonists of the response.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3152", "sentence": "Subsequently binding sites have been demonstrated in the plasma membrane of human lymphocytes which show pharmacological ( aldosterone specificity) and kinetic (high turnover) properties identical with those of the rapid aldosterone effects in the same cells.", "label": " ( cell type: human lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human lymphocytes, None) " }

[]

{ "id": "3153", "sentence": "SDS-PAGE analysis of the receptor protein has shown a molecular weight of approximately 50 kD .", "label": " ( protein: receptor protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: receptor protein, None) " }

[]

{ "id": "3154", "sentence": "The present paper reviews the data supporting a new, two-step model for non-genomic and genomic aldosterone effects.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3155", "sentence": "It also suggests a novel specificity-conferring mechanism for mineralocorticoid action at the membrane level .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3156", "sentence": "The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor .", "label": " ( protein: macrophage transcription factor, None) , ( protein: PU.1, None) , ( protein: macrophage colony-stimulating factor receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: macrophage transcription factor, None) , ( protein: PU.1, None) , ( protein: macrophage colony-stimulating factor receptor, None) " }

[]

{ "id": "3157", "sentence": "The macrophage colony-stimulating factor ( M-CSF ) receptor is expressed in a tissue-specific fashion from two distinct promoters in monocytes/macrophages and the placenta .", "label": " ( protein: M-CSF, None) , ( DNA: promoters, None) , ( protein: macrophage colony-stimulating factor ( M-CSF ) receptor, None) , ( protein: macrophage colony-stimulating factor, None) , ( cell type: monocytes/macrophages, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: M-CSF, None) , ( DNA: promoters, None) , ( protein: macrophage colony-stimulating factor ( M-CSF ) receptor, None) , ( protein: macrophage colony-stimulating factor, None) , ( cell type: monocytes/macrophages, None) " }

[]

{ "id": "3158", "sentence": "In order to further understand the transcription factors which play a role in the commitment of multipotential progenitors to the monocyte/macrophage lineage, we have initiated an investigation of the factors which activate the M-CSF receptor very early during the monocyte differentiation process .", "label": " ( protein: M-CSF receptor, None) , ( cell type: multipotential progenitors, None) , ( protein: M-CSF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: M-CSF receptor, None) , ( cell type: multipotential progenitors, None) , ( protein: M-CSF, None) " }

[]

{ "id": "3159", "sentence": "Here we demonstrate that the human monocytic M-CSF receptor promoter directs reporter gene activity in a tissue-specific fashion .", "label": " ( protein: M-CSF receptor, None) , ( protein: M-CSF, None) , ( DNA: human monocytic M-CSF receptor promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: M-CSF receptor, None) , ( protein: M-CSF, None) , ( DNA: human monocytic M-CSF receptor promoter, None) " }

[]

{ "id": "3160", "sentence": "Since one of the few transcription factors which have been implicated in the regulation of monocyte genes is the macrophage- and B-cell-specific PU.1 transcription factor , we investigated whether PU.1 binds and activates the M-CSF receptor promoter .", "label": " ( protein: transcription factors, None) , ( protein: M-CSF, None) , ( protein: PU.1, None) , ( DNA: monocyte genes, None) , ( protein: PU.1, None) , ( protein: transcription factor, None) , ( DNA: M-CSF receptor promoter, None) , ( protein: macrophage- and B-cell-specific PU.1, None) , ( protein: M-CSF receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) , ( protein: M-CSF, None) , ( protein: PU.1, None) , ( DNA: monocyte genes, None) , ( protein: PU.1, None) , ( protein: transcription factor, None) , ( DNA: M-CSF receptor promoter, None) , ( protein: macrophage- and B-cell-specific PU.1, None) , ( protein: M-CSF receptor, None) " }

[]

{ "id": "3161", "sentence": "Here we demonstrate that both in vitro-translated PU.1 and PU.1 from nuclear extracts bind to a specific site in the M-CSF receptor promoter just upstream from the major transcription initiation site .", "label": " ( protein: M-CSF receptor, None) , ( DNA: major transcription initiation site, None) , ( protein: PU.1, None) , ( protein: PU.1, None) , ( protein: vitro-translated PU.1, None) , ( protein: M-CSF, None) , ( DNA: M-CSF receptor promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: M-CSF receptor, None) , ( DNA: major transcription initiation site, None) , ( protein: PU.1, None) , ( protein: PU.1, None) , ( protein: vitro-translated PU.1, None) , ( protein: M-CSF, None) , ( DNA: M-CSF receptor promoter, None) " }

[]

{ "id": "3162", "sentence": "Mutations in this site which eliminate PU.1 binding decrease M-CSF receptor promoter activity significantly in macrophage cell lines only.", "label": " ( protein: M-CSF, None) , ( cell line: macrophage cell lines, None) , ( protein: PU.1, None) , ( protein: M-CSF receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: M-CSF, None) , ( cell line: macrophage cell lines, None) , ( protein: PU.1, None) , ( protein: M-CSF receptor, None) " }

[]

{ "id": "3163", "sentence": "Furthermore, PU.1 transactivates the M-CSF receptor promoter in nonmacrophage cells .", "label": " ( DNA: M-CSF receptor promoter, None) , ( cell type: nonmacrophage cells, None) , ( protein: PU.1, None) , ( protein: M-CSF receptor, None) , ( protein: M-CSF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: M-CSF receptor promoter, None) , ( cell type: nonmacrophage cells, None) , ( protein: PU.1, None) , ( protein: M-CSF receptor, None) , ( protein: M-CSF, None) " }

[]

{ "id": "3164", "sentence": "These results suggest that PU.1 plays a major role in macrophage gene regulation and development by directing the expression of a receptor for a key macrophage growth factor .", "label": " ( protein: PU.1, None) , ( protein: key macrophage growth factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PU.1, None) , ( protein: key macrophage growth factor, None) " }

[]

{ "id": "3165", "sentence": "Increased natural killer cell activity correlates with low or negative expression of the HER-2/neu oncogene in patients with breast cancer .", "label": " ( DNA: HER-2/neu oncogene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: HER-2/neu oncogene, None) " }

[]

{ "id": "3166", "sentence": "BACKGROUND.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3167", "sentence": "Increased expression of the HER-2/neu oncogene in breast cancer correlates with decreased estrogen receptor concentration and seems to be an important prognostic factor.", "label": " ( DNA: HER-2/neu oncogene, None) , ( protein: estrogen receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: HER-2/neu oncogene, None) , ( protein: estrogen receptor, None) " }

[]

{ "id": "3168", "sentence": "The authors investigated whether there is a correlation between HER-2/neu expression and immunologic parameters representing tumor defense in patients with breast cancer .", "label": " ( protein: HER-2/neu, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HER-2/neu, None) " }

[]

{ "id": "3169", "sentence": "METHOD.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3170", "sentence": "A Western blot analysis was used to investigate HER-2/neu expression , whereas a chromium-release assay using the K562 cell line as target was used to measure natural killer (NK) cell activity .", "label": " ( protein: HER-2/neu, None) , ( cell type: natural killer (NK) cell, None) , ( cell line: K562 cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HER-2/neu, None) , ( cell type: natural killer (NK) cell, None) , ( cell line: K562 cell line, None) " }

[]

{ "id": "3171", "sentence": "RESULTS.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3172", "sentence": "In patients with breast cancer , NK cell activity was significantly higher compared with patients with benign tumors (P = 0.006) or healthy control subjects (P = 0.002).", "label": " ( cell type: NK cell, None) , ( cell type: benign tumors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: NK cell, None) , ( cell type: benign tumors, None) " }

[]

{ "id": "3173", "sentence": "Moreover, 23.3% of patients with breast cancer showed an overexpression of HER-2/neu protein .", "label": " ( protein: HER-2/neu protein, None) , ( protein: HER-2/neu, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HER-2/neu protein, None) , ( protein: HER-2/neu, None) " }

[]

{ "id": "3174", "sentence": "Within this group of patients , NK cell activity was significantly lower (45.6 +/- 16.1%) compared with the group with no HER-2/neu overexpression (57.3 +/- 11.0%).", "label": " ( cell type: NK cell, None) , ( protein: HER-2/neu, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: NK cell, None) , ( protein: HER-2/neu, None) " }

[]

{ "id": "3175", "sentence": "NK cell activity did not increase in patients with HER-2/neu overexpression .", "label": " ( cell type: NK cell, None) , ( protein: HER-2/neu, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: NK cell, None) , ( protein: HER-2/neu, None) " }

[]

{ "id": "3176", "sentence": "Thus, there was a statistically significant correlation of cytolytic effector cell function with HER-2/neu expression of the tumor (P = 0.003), and HER-2/neu overexpression correlated with a negative estrogen receptor status (P = 0.005).", "label": " ( protein: estrogen receptor, None) , ( protein: HER-2/neu, None) , ( protein: HER-2/neu, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: estrogen receptor, None) , ( protein: HER-2/neu, None) , ( protein: HER-2/neu, None) " }

[]

{ "id": "3177", "sentence": "CONCLUSION.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3178", "sentence": "These data add further evidence to previous observations from the authors' laboratory that certain tumor characteristics may be associated with reactions of the host with breast cancer .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3179", "sentence": "[The value of the clinical test of glucocorticoid receptors of peripheral blood leukocytes in patients with chronic pulmonary heart disease ]", "label": " ( cell type: peripheral blood leukocytes, None) , ( protein: glucocorticoid receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral blood leukocytes, None) , ( protein: glucocorticoid receptors, None) " }

[]

{ "id": "3180", "sentence": "In order to inquire into the functional state of adrenal cortex in patients with pulmonary heart disease , the number of glucocorticoid receptors ( GCR ) of peripheral blood leukocytes in patients with chronic pulmonary heart disease was determined with radioligand-binding assay and the corresponding plasma cortisol levels were assessed with radioimmune assays .", "label": " ( protein: glucocorticoid receptors, None) , ( protein: GCR, None) , ( cell type: peripheral blood leukocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptors, None) , ( protein: GCR, None) , ( cell type: peripheral blood leukocytes, None) " }

[]

{ "id": "3181", "sentence": "The results showed that the number of GCR in the patients was significantly reduced (P < 0.01) and it was increased when their health state was improved.", "label": " ( protein: GCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCR, None) " }

[]

{ "id": "3182", "sentence": "However, it was still lower than that in healthy subjects (P < 0.01).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3183", "sentence": "The number of GCR in the patients was greatly increased when these patients were treated with oxygen (P < 0.01).", "label": " ( protein: GCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCR, None) " }

[]

{ "id": "3184", "sentence": "No difference in plasma cortisol was found between the patients and the healthy subjects (P > 0.05).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3185", "sentence": "These results indicate that the function of adrenal cortex may be improved by the compensation mechanism of the patients , but the lower GCR number was the result of lacking of oxygen in the patients .", "label": " ( protein: GCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCR, None) " }

[]

{ "id": "3186", "sentence": "The number of GCR may be improved by inhalation of oxygen .", "label": " ( protein: GCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCR, None) " }

[]

{ "id": "3187", "sentence": "Therefore oxygen therapy is helpful in raising the activity of glucocorticoid receptors and controlling the development of the disease.", "label": " ( protein: glucocorticoid receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptors, None) " }

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{ "id": "3188", "sentence": "Signaling via IL-2 and IL-4 in JAK3 -deficient severe combined immunodeficiency lymphocytes : JAK3 -dependent and independent pathways .", "label": " ( protein: JAK3, None) , ( protein: JAK3, None) , ( protein: IL-4, None) , ( protein: IL-2, None) , ( cell line: JAK3 -deficient severe combined immunodeficiency lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: JAK3, None) , ( protein: JAK3, None) , ( protein: IL-4, None) , ( protein: IL-2, None) , ( cell line: JAK3 -deficient severe combined immunodeficiency lymphocytes, None) " }

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{ "id": "3189", "sentence": "Both IL-2 and IL-4 bind to receptors containing the common gamma chain and JAK3 .", "label": " ( protein: JAK3, None) , ( protein: IL-2, None) , ( protein: common gamma chain, None) , ( protein: IL-4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: JAK3, None) , ( protein: IL-2, None) , ( protein: common gamma chain, None) , ( protein: IL-4, None) " }

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{ "id": "3190", "sentence": "Although JAK3 is required for proper lymphoid development , the precise roles of this kinase in IL-2 and IL-4 signaling in lymphocytes have not been defined.", "label": " ( protein: IL-2, None) , ( protein: JAK3, None) , ( cell type: lymphocytes, None) , ( protein: IL-4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( protein: JAK3, None) , ( cell type: lymphocytes, None) , ( protein: IL-4, None) " }

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{ "id": "3191", "sentence": "Here, we have studied IL-2 and IL-4 signaling in B cell lines lacking JAK3 .", "label": " ( protein: JAK3, None) , ( protein: IL-2, None) , ( cell line: B cell lines, None) , ( protein: IL-4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: JAK3, None) , ( protein: IL-2, None) , ( cell line: B cell lines, None) , ( protein: IL-4, None) " }

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{ "id": "3192", "sentence": "Although IL-2 -induced phosphorylation of IL-2R beta , JAK1 , and STAT5 all required the presence of JAK3 , IL-4 -mediated phosphorylation of JAK1 , STAT6 , and insulin receptor substrates 1 and 2 did not.", "label": " ( protein: JAK3, None) , ( protein: JAK1, None) , ( protein: IL-2R beta, None) , ( protein: STAT6, None) , ( protein: insulin receptor, None) , ( protein: IL-2, None) , ( protein: JAK1, None) , ( protein: STAT5, None) , ( protein: IL-4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: JAK3, None) , ( protein: JAK1, None) , ( protein: IL-2R beta, None) , ( protein: STAT6, None) , ( protein: insulin receptor, None) , ( protein: IL-2, None) , ( protein: JAK1, None) , ( protein: STAT5, None) , ( protein: IL-4, None) " }

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{ "id": "3193", "sentence": "However, IL-4 -induced effects were clearly improved following JAK3 expression .", "label": " ( protein: JAK3, None) , ( protein: IL-4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: JAK3, None) , ( protein: IL-4, None) " }

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{ "id": "3194", "sentence": "These data indicate that IL-4 signaling occurs in the absence of of JAK3 , but is comparatively inefficient.", "label": " ( protein: JAK3, None) , ( protein: IL-4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: JAK3, None) , ( protein: IL-4, None) " }

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{ "id": "3195", "sentence": "These findings may help in understanding the pathogenesis of the immunodeficiency that occurs with mutations of JAK3 and may suggest a mechanism for the pleiotropic effects of IL-4 .", "label": " ( protein: IL-4, None) , ( protein: JAK3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-4, None) , ( protein: JAK3, None) " }

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{ "id": "3196", "sentence": "Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor alpha gene [published erratum appears in Mol Cell Biol 1997 Apr;17(4):2351]", "label": " ( protein: human interleukin-2 receptor alpha, None) , ( DNA: human interleukin-2 receptor alpha gene, None) , ( protein: Stat5, None) , ( protein: Elf-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: human interleukin-2 receptor alpha, None) , ( DNA: human interleukin-2 receptor alpha gene, None) , ( protein: Stat5, None) , ( protein: Elf-1, None) " }

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{ "id": "3197", "sentence": "The interleukin 2 receptor alpha-chain ( IL-2R alpha ) gene is a key regulator of lymphocyte proliferation .", "label": " ( protein: IL-2R alpha, None) , ( DNA: interleukin 2 receptor alpha-chain ( IL-2R alpha ) gene, None) , ( protein: interleukin 2 receptor alpha-chain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2R alpha, None) , ( DNA: interleukin 2 receptor alpha-chain ( IL-2R alpha ) gene, None) , ( protein: interleukin 2 receptor alpha-chain, None) " }

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{ "id": "3198", "sentence": "IL-2R alpha is rapidly and potently induced in T cells in response to mitogenic stimuli .", "label": " ( cell type: T cells, None) , ( protein: IL-2R alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: IL-2R alpha, None) " }

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{ "id": "3199", "sentence": "Interleukin 2 ( IL-2 ) stimulates IL-2R alpha .", "label": " ( protein: IL-2, None) , ( protein: IL-2R alpha, None) , ( protein: Interleukin 2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( protein: IL-2R alpha, None) , ( protein: Interleukin 2, None) " }