Datasets:

huy-nh-2000

/

instructUIE

like 0

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{ "id": "2900", "sentence": "Contrary to the idea that protein kinase C is involved in TCR -mediated activation of NF-kappaB , high doses of staurosporine did not interfere with activation of NF-kappaB by PHA , while the same dose of staurosporine completely blocked activation by PMA .", "label": " ( protein: TCR, None) , ( protein: PHA, None) , ( protein: protein kinase C, None) , ( protein: NF-kappaB, None) , ( protein: NF-kappaB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TCR, None) , ( protein: PHA, None) , ( protein: protein kinase C, None) , ( protein: NF-kappaB, None) , ( protein: NF-kappaB, None) " }

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{ "id": "2901", "sentence": "PHA -induced kappaB-dependent reporter activity was, however, effectively blocked by a dominant negative form of Raf-1 , suggesting a critical role for a Raf kinase .", "label": " ( protein: Raf-1, None) , ( protein: PHA, None) , ( protein: Raf kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Raf-1, None) , ( protein: PHA, None) , ( protein: Raf kinase, None) " }

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{ "id": "2902", "sentence": "The TCR -mediated activation of NF-kappaB was also dependent on a Ca2+ influx , because the Ca2+ channel blocker, SK&F 96365, as well as other agents that prevented the Ca2+ influx, inhibited NF-kappaB activation .", "label": " ( protein: NF-kappaB, None) , ( protein: NF-kappaB, None) , ( protein: TCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappaB, None) , ( protein: NF-kappaB, None) , ( protein: TCR, None) " }

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{ "id": "2903", "sentence": "Cotransfection of a constitutively active form of calcineurin largely substituted for the Ca2+ requirement and reversed the blockade by SK&F 96365 .", "label": " ( protein: calcineurin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: calcineurin, None) " }

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{ "id": "2904", "sentence": "Consistent with these observations, coexpression of constitutively active forms of Raf-1 and calcineurin synergistically induced kappaB -dependent reporter activity , suggesting a physiologically relevant functional interaction between the kinase and the phosphatase .", "label": " ( protein: Raf-1, None) , ( protein: calcineurin, None) , ( protein: kinase, None) , ( protein: phosphatase, None) , ( protein: kappaB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Raf-1, None) , ( protein: calcineurin, None) , ( protein: kinase, None) , ( protein: phosphatase, None) , ( protein: kappaB, None) " }

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{ "id": "2905", "sentence": "Synergistic interactions between overlapping binding sites for the serum response factor and ELK-1 proteins mediate both basal enhancement and phorbol ester responsiveness of primate cytomegalovirus major immediate-early promoters in monocyte and T-lymphocyte cell types.", "label": " ( protein: ELK-1 proteins, None) , ( protein: serum response factor, None) , ( DNA: overlapping binding sites, None) , ( DNA: primate cytomegalovirus major immediate-early promoters, None) , ( cell type: T-lymphocyte, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ELK-1 proteins, None) , ( protein: serum response factor, None) , ( DNA: overlapping binding sites, None) , ( DNA: primate cytomegalovirus major immediate-early promoters, None) , ( cell type: T-lymphocyte, None) " }

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{ "id": "2906", "sentence": "Cytomegalovirus (CMV) infection is nonpermissive or persistent in many lymphoid and myeloid cell types but can be activated in differentiated macrophages .", "label": " ( cell type: differentiated macrophages, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: differentiated macrophages, None) " }

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{ "id": "2907", "sentence": "We have shown elsewhere that both the major immediate-early gene ( MIE ) and lytic cycle infectious progeny virus expression can be induced in otherwise nonpermissive monocyte-like U-937 cell cultures infected with either human CMV ( HCMV ) or simian CMV ( SCMV ) by treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate ( TPA ).", "label": " ( DNA: MIE, None) , ( cell line: monocyte-like U-937 cell cultures, None) , ( DNA: major immediate-early gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: MIE, None) , ( cell line: monocyte-like U-937 cell cultures, None) , ( DNA: major immediate-early gene, None) " }

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{ "id": "2908", "sentence": "Two multicopy basal enhancer motifs within the SCMV MIE enhancer , namely, 11 copies of the 16-bp cyclic AMP response element ( CRE ) and 3 copies of novel 17-bp serum response factor ( SRF ) binding sites referred to as the SNE ( SRF/NFkappaB-like element ), as well as four classical NFkappaB sites within the HCMV version, contribute to TPA responsiveness in transient assays in monocyte and T- cell types .", "label": " ( protein: SRF, None) , ( DNA: MIE enhancer, None) , ( DNA: NFkappaB sites, None) , ( DNA: CRE, None) , ( protein: serum response factor, None) , ( DNA: SNE, None) , ( DNA: cyclic AMP response element, None) , ( DNA: SRF/NFkappaB-like element, None) , ( DNA: MIE, None) , ( DNA: serum response factor ( SRF ) binding sites, None) , ( DNA: multicopy basal enhancer motifs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: SRF, None) , ( DNA: MIE enhancer, None) , ( DNA: NFkappaB sites, None) , ( DNA: CRE, None) , ( protein: serum response factor, None) , ( DNA: SNE, None) , ( DNA: cyclic AMP response element, None) , ( DNA: SRF/NFkappaB-like element, None) , ( DNA: MIE, None) , ( DNA: serum response factor ( SRF ) binding sites, None) , ( DNA: multicopy basal enhancer motifs, None) " }

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{ "id": "2909", "sentence": "The SCMV SNE sites contain potential overlapping core recognition binding motifs for SRF , Rel/NFkappaB , ETS , and YY1 class transcription factors but fail to respond to either serum or tumor necrosis factor alpha .", "label": " ( protein: ETS, None) , ( protein: Rel/NFkappaB, None) , ( protein: SRF, None) , ( DNA: SCMV SNE sites, None) , ( protein: YY1 class transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ETS, None) , ( protein: Rel/NFkappaB, None) , ( protein: SRF, None) , ( DNA: SCMV SNE sites, None) , ( protein: YY1 class transcription factors, None) " }

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{ "id": "2910", "sentence": "Therefore, to evaluate the mechanism of TPA responsiveness of the SNE motifs and of a related 16-bp SEE ( SRF/ ETS element ) motif found in the HCMV and chimpanzee CMV MIE enhancers , we have examined the functional responses and protein binding properties of multimerized wild-type and mutant elements added upstream to the SCMV MIE or simian virus 40 minimal promoter regions in the U-937 , K-562 , HL-60 , THP-1 , and Jurkat cell lines .", "label": " ( DNA: SEE, None) , ( DNA: SNE motifs, None) , ( cell line: THP-1, None) , ( cell line: Jurkat cell lines, None) , ( DNA: SCMV MIE, None) , ( cell line: HL-60, None) , ( DNA: SRF/ ETS element, None) , ( DNA: simian virus 40 minimal promoter regions, None) , ( cell line: U-937, None) , ( DNA: SNE, None) , ( DNA: MIE, None) , ( cell line: K-562, None) , ( protein: ETS, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: SEE, None) , ( DNA: SNE motifs, None) , ( cell line: THP-1, None) , ( cell line: Jurkat cell lines, None) , ( DNA: SCMV MIE, None) , ( cell line: HL-60, None) , ( DNA: SRF/ ETS element, None) , ( DNA: simian virus 40 minimal promoter regions, None) , ( cell line: U-937, None) , ( DNA: SNE, None) , ( DNA: MIE, None) , ( cell line: K-562, None) , ( protein: ETS, None) " }

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{ "id": "2911", "sentence": "Unlike classical NFkappaB sites , neither the SNE nor the SEE motif responded to phosphatase inhibition by okadaic acid.", "label": " ( DNA: SNE, None) , ( DNA: SEE, None) , ( DNA: SEE motif, None) , ( DNA: NFkappaB sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: SNE, None) , ( DNA: SEE, None) , ( DNA: SEE motif, None) , ( DNA: NFkappaB sites, None) " }

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{ "id": "2912", "sentence": "However, the TPA responsiveness of both CMV elements proved to involve synergistic interactions between the core SRF binding site ( CCATATATGG ) and the adjacent inverted ETS binding motifs ( TTCC ), which correlated directly with formation of a bound tripartite complex containing both the cellular SRF and ELK-1 proteins .", "label": " ( protein: ETS, None) , ( protein: SRF, None) , ( protein: tripartite complex, None) , ( DNA: CMV elements, None) , ( DNA: ETS binding motifs, None) , ( protein: ELK-1 proteins, None) , ( protein: SRF, None) , ( DNA: SRF binding site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ETS, None) , ( protein: SRF, None) , ( protein: tripartite complex, None) , ( DNA: CMV elements, None) , ( DNA: ETS binding motifs, None) , ( protein: ELK-1 proteins, None) , ( protein: SRF, None) , ( DNA: SRF binding site, None) " }

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{ "id": "2913", "sentence": "This protein complex was more abundant in U-937 , K-562 , and HeLa cell extracts than in Raji , HF , BALB/c 3T3 , or HL-60 cells , but the binding activity was altered only twofold after TPA treatment.", "label": " ( cell line: HL-60 cells, None) , ( cell line: Raji, None) , ( cell line: HF, None) , ( protein: protein complex, None) , ( cell line: BALB/c 3T3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL-60 cells, None) , ( cell line: Raji, None) , ( cell line: HF, None) , ( protein: protein complex, None) , ( cell line: BALB/c 3T3, None) " }

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{ "id": "2914", "sentence": "A 40-fold stimulation of chloramphenicol acetyltransferase activity mediated by four tandem repeats of the SNE could be induced within 2 h (and up to 250-fold within 6 h) after addition of TPA in DNA-transfected U-937 cells , indicating that the stimulation appeared likely to be a true protein kinase C -mediated signal transduction event rather than a differentiation response .", "label": " ( DNA: SNE, None) , ( protein: protein kinase C, None) , ( DNA: tandem repeats, None) , ( cell line: U-937 cells, None) , ( cell line: DNA-transfected U-937 cells, None) , ( protein: chloramphenicol acetyltransferase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: SNE, None) , ( protein: protein kinase C, None) , ( DNA: tandem repeats, None) , ( cell line: U-937 cells, None) , ( cell line: DNA-transfected U-937 cells, None) , ( protein: chloramphenicol acetyltransferase, None) " }

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{ "id": "2915", "sentence": "Slight differences in the sequence of the core SRF binding site compared with that of the classical c-Fos promoter serum response element , together with differences in the spacing between the SRF and ETS motifs , appear to account for the inability of the SCMV SNEs to respond to serum induction .", "label": " ( DNA: c-Fos promoter serum response element, None) , ( DNA: core SRF binding site, None) , ( DNA: SCMV SNEs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: c-Fos promoter serum response element, None) , ( DNA: core SRF binding site, None) , ( DNA: SCMV SNEs, None) " }

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{ "id": "2916", "sentence": "T-cell -directed TAL-1 expression induces T-cell malignancies in transgenic mice .", "label": " ( cell type: T-cell, None) , ( protein: TAL-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T-cell, None) , ( protein: TAL-1, None) " }

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{ "id": "2917", "sentence": "The TAL-1 gene specifies for a basic domain-helix-loop-helix protein , which is involved in the control of normal hematopoiesis .", "label": " ( DNA: TAL-1 gene, None) , ( protein: domain-helix-loop-helix protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: TAL-1 gene, None) , ( protein: domain-helix-loop-helix protein, None) " }

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{ "id": "2918", "sentence": "In human pathology, the TAL-1 gene product is expressed in a high percentage of T-cell acute lymphoblastic leukemias in the pediatric age range; however, it has not been established whether the expression has a causal role in oncogenesis .", "label": " ( cell type: T-cell, None) , ( DNA: TAL-1 gene, None) , ( protein: TAL-1 gene product, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T-cell, None) , ( DNA: TAL-1 gene, None) , ( protein: TAL-1 gene product, None) " }

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{ "id": "2919", "sentence": "In this report, we describe the phenotype of mouse transgenic lines obtained by inducing tal-1 protein expression in lymphoid tissues using the LCK promoter .", "label": " ( DNA: LCK promoter, None) , ( protein: tal-1 protein, None) , ( cell line: mouse transgenic lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LCK promoter, None) , ( protein: tal-1 protein, None) , ( cell line: mouse transgenic lines, None) " }

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{ "id": "2920", "sentence": "The survival rate of tal-1 transgenic animals was much lower as compared with control mice.", "label": " ( DNA: tal-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: tal-1, None) " }

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{ "id": "2921", "sentence": "Histopathological analysis revealed lymphomas of T-cell type , often comprising a minor B-cell component .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2922", "sentence": "Some mice showed marked splenic lymphocyte depletion .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2923", "sentence": "Primary lymphocyte cultures showed partial independence from exogenous growth stimuli and increased resistance to low-serum apoptosis .", "label": " ( cell line: Primary lymphocyte cultures, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Primary lymphocyte cultures, None) " }

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{ "id": "2924", "sentence": "To further unravel the tal-1 oncogenic potential , a strain of tal-1 transgenic mice was crossbred with p53-/- mice ; the survival rate in these animals was reduced by more than one-half when compared with that of tal-1 mice , and histopathological analysis revealed exclusively T-cell lymphomas .", "label": " ( DNA: tal-1, None) , ( DNA: tal-1, None) , ( cell type: T-cell, None) , ( DNA: tal-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: tal-1, None) , ( DNA: tal-1, None) , ( cell type: T-cell, None) , ( DNA: tal-1, None) " }

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{ "id": "2925", "sentence": "These data indicate that TAL-1 , expressed in T cells , is per se a potent oncogene, which may exert a key leukemogenetic role in the majority of T-cell acute lymphoblastic leukemias .", "label": " ( protein: TAL-1, None) , ( cell type: T cells, None) , ( cell type: T-cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TAL-1, None) , ( cell type: T cells, None) , ( cell type: T-cell, None) " }

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{ "id": "2926", "sentence": "Tissue and cell-type specific expression of the tuberous sclerosis gene , TSC2 , in human tissues .", "label": " ( DNA: TSC2, None) , ( DNA: tuberous sclerosis gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: TSC2, None) , ( DNA: tuberous sclerosis gene, None) " }

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{ "id": "2927", "sentence": "TSC2 is a gene on chromosome 16p13.3 associated with the autosomal dominant neurocutaneous disorder , tuberous sclerosis complex ( TSC ).", "label": " ( DNA: chromosome 16p13.3, None) , ( DNA: TSC2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: chromosome 16p13.3, None) , ( DNA: TSC2, None) " }

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{ "id": "2928", "sentence": "By using a partial nucleotide sequence from the cloned TSC2 and polymerase chain reaction methodology , we constructed a digoxigenin-labeled complementary DNA probe to examine TSC2 gene expression in autopsy- or biopsy-derived human tissues by in situ hybridization .", "label": " ( DNA: TSC2, None) , ( DNA: TSC2, None) , ( DNA: partial nucleotide sequence, None) , ( DNA: digoxigenin-labeled complementary DNA probe, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: TSC2, None) , ( DNA: TSC2, None) , ( DNA: partial nucleotide sequence, None) , ( DNA: digoxigenin-labeled complementary DNA probe, None) " }

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{ "id": "2929", "sentence": "TSC2 messenger RNA was widely expressed in various cell types throughout the body, including epithelia , lymphocytes , and cells with endocrine functions , e.g., adrenal cortex and anterior pituitary .", "label": " ( RNA: TSC2 messenger RNA, None) , ( DNA: TSC2, None) , ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: TSC2 messenger RNA, None) , ( DNA: TSC2, None) , ( cell type: lymphocytes, None) " }

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{ "id": "2930", "sentence": "It was prominently and selectively (within the central nervous system ) expressed in pyramidal cells of the cerebral cortex and other motor neurons , e.g., in spinal cord and brainstem nuclei .", "label": " ( cell type: motor neurons, None) , ( cell type: pyramidal cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: motor neurons, None) , ( cell type: pyramidal cells, None) " }

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{ "id": "2931", "sentence": "Visceral TSC2 expression was comparable in autopsy tissues from patients with and without TSC ; TSC2 messenger RNA expression was most prominent in cells with a rapid mitotic rate and turnover, e.g., epithelia and lymphocytes , with central nervous system pyramidal cells and other neurons being an obvious exception, and/or in cells with important secretory/transport functions.", "label": " ( DNA: TSC2, None) , ( cell type: pyramidal cells, None) , ( cell type: lymphocytes, None) , ( DNA: TSC2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: TSC2, None) , ( cell type: pyramidal cells, None) , ( cell type: lymphocytes, None) , ( DNA: TSC2, None) " }

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{ "id": "2932", "sentence": "This widespread expression of the TSC2 gene supports the view that it encodes a protein vital to cell growth and metabolism or one that functions as a tumor/growth suppressor .", "label": " ( DNA: TSC2 gene, None) , ( DNA: TSC2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: TSC2 gene, None) , ( DNA: TSC2, None) " }

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{ "id": "2933", "sentence": "Apoptosis signaling pathways in normal T cells : differential activity of Bcl-2 and IL-1beta -converting enzyme family protease inhibitors on glucocorticoid- and Fas- mediated cytotoxicity .", "label": " ( protein: Bcl-2, None) , ( cell type: T cells, None) , ( protein: IL-1beta, None) , ( protein: IL-1beta -converting enzyme family, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Bcl-2, None) , ( cell type: T cells, None) , ( protein: IL-1beta, None) , ( protein: IL-1beta -converting enzyme family, None) " }

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{ "id": "2934", "sentence": "Fas -mediated apoptosis plays an important role in regulating the immune response in peripheral T cells .", "label": " ( cell type: T cells, None) , ( cell type: peripheral T cells, None) , ( protein: Fas, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( cell type: peripheral T cells, None) , ( protein: Fas, None) " }

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{ "id": "2935", "sentence": "Restimulation of T cell blasts up-regulates Fas and Fas ligand expression , with subsequent interaction leading to cell death .", "label": " ( protein: Fas, None) , ( cell type: T cell blasts, None) , ( protein: Fas, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Fas, None) , ( cell type: T cell blasts, None) , ( protein: Fas, None) " }

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{ "id": "2936", "sentence": "Overexpression of Bcl-2 in tumor cells blocks apoptosis induced by many stimuli, but inhibition of Fas -mediated killing has not been consistently observed.", "label": " ( protein: Fas, None) , ( protein: Bcl-2, None) , ( cell type: tumor cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Fas, None) , ( protein: Bcl-2, None) , ( cell type: tumor cells, None) " }

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{ "id": "2937", "sentence": "To examine the behavior of Bcl-2 in normal cells , T cell blasts were transiently transfected with Bcl-2 and related gene products to determine the effect on apoptotic signaling.", "label": " ( protein: gene products, None) , ( cell type: T cell blasts, None) , ( cell type: normal cells, None) , ( protein: Bcl-2, None) , ( protein: Bcl-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: gene products, None) , ( cell type: T cell blasts, None) , ( cell type: normal cells, None) , ( protein: Bcl-2, None) , ( protein: Bcl-2, None) " }

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{ "id": "2938", "sentence": "Transient overexpression of Bcl-2 in mouse and human T cell blasts did not block Fas -mediated apoptosis , whereas etoposide- and glucocorticoid- induced cytotoxicity was potently inhibited.", "label": " ( protein: Fas, None) , ( cell type: T cell blasts, None) , ( protein: Bcl-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Fas, None) , ( cell type: T cell blasts, None) , ( protein: Bcl-2, None) " }

[]

{ "id": "2939", "sentence": "Expression of Bcl-xL and adenovirus E1B 19K did not interfere with anti- Fas killing .", "label": " ( protein: Bcl-xL, None) , ( protein: adenovirus E1B 19K, None) , ( protein: Fas, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Bcl-xL, None) , ( protein: adenovirus E1B 19K, None) , ( protein: Fas, None) " }

[]

{ "id": "2940", "sentence": "In contrast, interleukin-1beta-converting enzyme family protease inhibitors Ac-DEVD-CHO and CrmA blocked Fas -mediated apoptosis .", "label": " ( protein: Fas, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Fas, None) " }

[]

{ "id": "2941", "sentence": "These results suggest that peripheral T cells use distinct apoptosis signaling pathways with differential sensitivity to Bcl-2 and interleukin-1beta-converting enzyme family protease inhibitors .", "label": " ( cell type: T cells, None) , ( protein: Bcl-2, None) , ( cell type: peripheral T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: Bcl-2, None) , ( cell type: peripheral T cells, None) " }

[]

{ "id": "2942", "sentence": "Since T cells normally express Bcl-2 and Bcl-xL following activation, their inability to block Fas -mediated apoptosis may allow for the elimination of self-reactive cells and the appropriate regulation of immune responses .", "label": " ( protein: Bcl-xL, None) , ( cell type: T cells, None) , ( cell type: self-reactive cells, None) , ( protein: Bcl-2, None) , ( protein: Fas, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Bcl-xL, None) , ( cell type: T cells, None) , ( cell type: self-reactive cells, None) , ( protein: Bcl-2, None) , ( protein: Fas, None) " }

[]

{ "id": "2943", "sentence": "Increased interleukin 2 transcription in murine lymphocytes by ciprofloxacin .", "label": " ( cell type: murine lymphocytes, None) , ( protein: interleukin 2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: murine lymphocytes, None) , ( protein: interleukin 2, None) " }

[]

{ "id": "2944", "sentence": "The fluoroquinolone antibiotic , ciprofloxacin ( cipro ), induces hyperproduction of interleukin 2 ( IL-2 ) and interferon-gamma ( IFN-gamma ) in stimulated human peripheral blood lymphocytes .", "label": " ( cell type: human peripheral blood lymphocytes, None) , ( protein: interferon-gamma, None) , ( protein: IFN-gamma, None) , ( protein: interleukin 2, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human peripheral blood lymphocytes, None) , ( protein: interferon-gamma, None) , ( protein: IFN-gamma, None) , ( protein: interleukin 2, None) , ( protein: IL-2, None) " }

[]

{ "id": "2945", "sentence": "In this investigation an enhanced and prolonged IL-2 and IL-2 mRNA response was also detected in both stimulated ( T cell mitogens or alloantigens ) murine splenocytes and in the stimulated murine T cell line EL-4 in the presence of ciprofloxacin (5-80 micrograms/ml) as compared to control cells without antibiotics .", "label": " ( cell line: murine T cell line EL-4, None) , ( protein: IL-2, None) , ( cell type: murine splenocytes, None) , ( protein: alloantigens, None) , ( RNA: IL-2 mRNA, None) , ( protein: T cell mitogens, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: murine T cell line EL-4, None) , ( protein: IL-2, None) , ( cell type: murine splenocytes, None) , ( protein: alloantigens, None) , ( RNA: IL-2 mRNA, None) , ( protein: T cell mitogens, None) " }

[]

{ "id": "2946", "sentence": "However, in contrast to human lymphocytes , IFN-gamma production was inhibited and IFN-gamma mRNA levels were unaffected at 24 h and only slightly upregulated at 48 and 72 h of culture in murine splenocytes incubated with cipro (20 micrograms/ml).", "label": " ( protein: IFN-gamma, None) , ( RNA: IFN-gamma mRNA, None) , ( cell type: human lymphocytes, None) , ( protein: IFN-gamma, None) , ( cell type: murine splenocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN-gamma, None) , ( RNA: IFN-gamma mRNA, None) , ( cell type: human lymphocytes, None) , ( protein: IFN-gamma, None) , ( cell type: murine splenocytes, None) " }

[]

{ "id": "2947", "sentence": "EL-4 cells were transfected with a plasmid containing the IL-2 promoter and enhancer region linked to the chloramphenicol acetyltransferase ( CAT ) reporter gene .", "label": " ( protein: CAT, None) , ( DNA: enhancer region, None) , ( DNA: chloramphenicol acetyltransferase ( CAT ) reporter gene, None) , ( protein: chloramphenicol acetyltransferase, None) , ( DNA: IL-2 promoter, None) , ( cell type: EL-4 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CAT, None) , ( DNA: enhancer region, None) , ( DNA: chloramphenicol acetyltransferase ( CAT ) reporter gene, None) , ( protein: chloramphenicol acetyltransferase, None) , ( DNA: IL-2 promoter, None) , ( cell type: EL-4 cells, None) " }

[]

{ "id": "2948", "sentence": "Analysis of CAT activity revealed that cipro enhanced IL-2 gene induction.", "label": " ( protein: CAT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CAT, None) " }

[]

{ "id": "2949", "sentence": "In addition, EL-4 cells incubated with ciprofloxacin showed an early peak and more activated nuclear factor of activated T cells ( NFAT-1 ) as compared to control cells without antibiotics .", "label": " ( protein: NFAT-1, None) , ( cell type: activated T cells, None) , ( cell type: EL-4 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NFAT-1, None) , ( cell type: activated T cells, None) , ( cell type: EL-4 cells, None) " }

[]

{ "id": "2950", "sentence": "Cipro did not affect the nuclear transcription factors AP-1 or NFIL-2A .", "label": " ( protein: AP-1, None) , ( protein: NFIL-2A, None) , ( protein: nuclear transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( protein: NFIL-2A, None) , ( protein: nuclear transcription factors, None) " }

[]

{ "id": "2951", "sentence": "Taken together, cipro inhibited IFN-gamma synthesis , but enhanced IL-2 production in murine lymphocytes by means of influencing NFAT-1 and causing an increased IL-2 transcription .", "label": " ( protein: IFN-gamma, None) , ( protein: IL-2, None) , ( protein: IL-2, None) , ( cell type: murine lymphocytes, None) , ( protein: NFAT-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN-gamma, None) , ( protein: IL-2, None) , ( protein: IL-2, None) , ( cell type: murine lymphocytes, None) , ( protein: NFAT-1, None) " }

[]

{ "id": "2952", "sentence": "Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product : implications for viral latency.", "label": " ( protein: Tax, None) , ( protein: NF-kappa B2 p100 gene product, None) , ( DNA: NF-kappa B2 p100 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tax, None) , ( protein: NF-kappa B2 p100 gene product, None) , ( DNA: NF-kappa B2 p100 gene, None) " }

[]

{ "id": "2953", "sentence": "Human T-cell leukemia virus type I ( HTLV-I ) is the etiologic agent of the adult T-cell leukemia , an aggressive and often fatal malignancy of activated human CD4 T cells .", "label": " ( cell line: activated human CD4 T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: activated human CD4 T cells, None) " }

[]

{ "id": "2954", "sentence": "HTLV-I encodes an essential 40-kDa protein termed Tax that not only transactivates the long terminal repeat of this retrovirus but also induces an array of cellular genes .", "label": " ( protein: 40-kDa protein, None) , ( protein: Tax, None) , ( DNA: cellular genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: 40-kDa protein, None) , ( protein: Tax, None) , ( DNA: cellular genes, None) " }

[]

{ "id": "2955", "sentence": "Tax -mediated transformation of T cells likely involves the deregulated expression of various cellular genes that normally regulate lymphocyte growth produced by altered activity of various endogenous host transcription factors .", "label": " ( protein: Tax, None) , ( DNA: cellular genes, None) , ( protein: transcription factors, None) , ( cell type: T cells, None) , ( cell type: lymphocyte, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tax, None) , ( DNA: cellular genes, None) , ( protein: transcription factors, None) , ( cell type: T cells, None) , ( cell type: lymphocyte, None) " }

[]

{ "id": "2956", "sentence": "In particular, Tax is capable of modulating the expression or activity of various host transcription factors , including members of the NF-kappa B/Rel and CREB/ATF families , as well as the cellular factors HEB-1 and p67SRF .", "label": " ( protein: HEB-1, None) , ( protein: CREB/ATF families, None) , ( protein: NF-kappa B/Rel, None) , ( protein: transcription factors, None) , ( protein: cellular factors, None) , ( protein: Tax, None) , ( protein: p67SRF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HEB-1, None) , ( protein: CREB/ATF families, None) , ( protein: NF-kappa B/Rel, None) , ( protein: transcription factors, None) , ( protein: cellular factors, None) , ( protein: Tax, None) , ( protein: p67SRF, None) " }

[]

{ "id": "2957", "sentence": "An additional distinguishing characteristic of HTLV-I infection is the profound state of viral latency that is present in circulating primary leukemic T cells .", "label": " ( cell type: primary leukemic T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: primary leukemic T cells, None) " }

[]

{ "id": "2958", "sentence": "In this study, we demonstrate that HTLV-I Tax can physically associate with p100 , the product of the Rel-related NF-kappa B2 gene , both in transfected cells and in HTLV-I -infected leukemic T-cell lines .", "label": " ( cell line: transfected cells, None) , ( protein: Tax, None) , ( protein: p100, None) , ( cell line: HTLV-I -infected leukemic T-cell lines, None) , ( DNA: Rel-related NF-kappa B2 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: transfected cells, None) , ( protein: Tax, None) , ( protein: p100, None) , ( cell line: HTLV-I -infected leukemic T-cell lines, None) , ( DNA: Rel-related NF-kappa B2 gene, None) " }

[]

{ "id": "2959", "sentence": "Furthermore, the physical interaction of Tax with p100 leads to the inhibition of Tax -induced activation of the HTLV-I and human immunodeficiency virus type 1 long terminal repeats , reflecting p100 -mediated cytoplasmic sequestration of the normally nuclearly expressed Tax protein .", "label": " ( protein: p100, None) , ( DNA: human immunodeficiency virus type 1 long terminal repeats, None) , ( protein: Tax, None) , ( protein: Tax, None) , ( protein: p100, None) , ( protein: Tax protein, None) , ( protein: Tax, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p100, None) , ( DNA: human immunodeficiency virus type 1 long terminal repeats, None) , ( protein: Tax, None) , ( protein: Tax, None) , ( protein: p100, None) , ( protein: Tax protein, None) , ( protein: Tax, None) " }

[]

{ "id": "2960", "sentence": "In contrast, a mutant of Tax that selectively fails to activate nuclear NF-kappa B expression does not associate with p100 .", "label": " ( protein: Tax, None) , ( protein: NF-kappa B, None) , ( protein: p100, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tax, None) , ( protein: NF-kappa B, None) , ( protein: p100, None) " }

[]

{ "id": "2961", "sentence": "(ABSTRACT TRUNCATED AT 250 WORDS)", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2962", "sentence": "Rhabdomyosarcomas do not contain mutations in the DNA binding domains of myogenic transcription factors .", "label": " ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) " }

[]

{ "id": "2963", "sentence": "Skeletal myogenesis is regulated by a group of transcription factors ( MyoD , myogenin , myf5 , and myf6 ) that are \"basic helix-loop-helix\" proteins that bind to the promoters of muscle-specific genes and promote their expression.", "label": " ( protein: \"basic helix-loop-helix\" proteins, None) , ( protein: MyoD, None) , ( protein: myogenin, None) , ( DNA: promoters, None) , ( DNA: muscle-specific genes, None) , ( protein: myf5, None) , ( protein: transcription factors, None) , ( protein: myf6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: \"basic helix-loop-helix\" proteins, None) , ( protein: MyoD, None) , ( protein: myogenin, None) , ( DNA: promoters, None) , ( DNA: muscle-specific genes, None) , ( protein: myf5, None) , ( protein: transcription factors, None) , ( protein: myf6, None) " }

[]

{ "id": "2964", "sentence": "We have previously shown that after a mutation of Leu122 to Arg the DNA binding basic domain of MyoD confers c-myc -like functional characteristics to the protein.", "label": " ( protein: DNA binding basic domain, None) , ( protein: MyoD, None) , ( DNA: c-myc, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNA binding basic domain, None) , ( protein: MyoD, None) , ( DNA: c-myc, None) " }

[]

{ "id": "2965", "sentence": "In this study we used single-strand conformation polymorphism analysis to determine whether such mutations occur naturally in rhabdomyosarcomas .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2966", "sentence": "We have found that the basic domains of all the myogenic factors remain unaltered in rhabdomyosarcomas .", "label": " ( protein: basic domains, None) , ( protein: myogenic factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: basic domains, None) , ( protein: myogenic factors, None) " }

[]

{ "id": "2967", "sentence": "Selection against such mutations may be the result of functional redundancy of these myogenic transcription factors .", "label": " ( protein: transcription factors, None) , ( protein: myogenic transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) , ( protein: myogenic transcription factors, None) " }

[]

{ "id": "2968", "sentence": "Function and activation of NF-kappa B in the immune system .", "label": " ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) " }

[]

{ "id": "2969", "sentence": "NF-kappa B is a ubiquitous transcription factor .", "label": " ( protein: NF-kappa B, None) , ( protein: ubiquitous transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: ubiquitous transcription factor, None) " }

[]

{ "id": "2970", "sentence": "Nevertheless, its properties seem to be most extensively exploited in cells of the immune system .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2971", "sentence": "Among these properties are NF-kappa B 's rapid posttranslational activation in response to many pathogenic signals , its direct participation in cytoplasmic/nuclear signaling , and its potency to activate transcription of a great variety of genes encoding immunologically relevant proteins .", "label": " ( protein: immunologically relevant proteins, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: immunologically relevant proteins, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "2972", "sentence": "In vertebrates, five distinct DNA binding subunits are currently known which might extensively heterodimerize, thereby forming complexes with distinct transcriptional activity, DNA sequence specificity, and cell type- and cell stage-specific distribution.", "label": " ( protein: DNA binding subunits, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNA binding subunits, None) " }

[]

{ "id": "2973", "sentence": "The activity of DNA binding NF-kappa B dimers is tightly controlled by accessory proteins called I kappa B subunits of which there are also five different species currently known in vertebrates .", "label": " ( protein: NF-kappa B, None) , ( protein: accessory proteins, None) , ( protein: I kappa B subunits, None) , ( protein: DNA binding NF-kappa B dimers, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: accessory proteins, None) , ( protein: I kappa B subunits, None) , ( protein: DNA binding NF-kappa B dimers, None) " }

[]

{ "id": "2974", "sentence": "I kappa B proteins inhibit DNA binding and prevent nuclear uptake of NF-kappa B complexes .", "label": " ( protein: I kappa B proteins, None) , ( protein: NF-kappa B complexes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I kappa B proteins, None) , ( protein: NF-kappa B complexes, None) " }

[]

{ "id": "2975", "sentence": "An exception is the Bcl-3 protein which in addition can function as a transcription activating subunit in th nucleus .", "label": " ( protein: Bcl-3 protein, None) , ( protein: transcription activating subunit, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Bcl-3 protein, None) , ( protein: transcription activating subunit, None) " }

[]

{ "id": "2976", "sentence": "Other I kappa B proteins are rather involved in terminating NF-kappa B 's activity in the nucleus .", "label": " ( protein: NF-kappa B, None) , ( protein: I kappa B proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: I kappa B proteins, None) " }

[]

{ "id": "2977", "sentence": "The intracellular events that lead to the inactivation of I kappa B , i.e. the activation of NF-kappa B , are complex.", "label": " ( protein: NF-kappa B, None) , ( protein: I kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: I kappa B, None) " }

[]

{ "id": "2978", "sentence": "They involve phosphorylation and proteolytic reactions and seem to be controlled by the cells' redox status .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2979", "sentence": "Interference with the activation or activity of NF-kappa B may be beneficial in suppressing toxic/septic shock , graft-vs-host reactions , acute inflammatory reactions , acute phase response , and radiation damage .", "label": " ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) " }

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{ "id": "2980", "sentence": "The inhibition of NF-kappa B activation by antioxidants and specific protease inhibitors may provide a pharmacological basis for interfering with these acute processes .", "label": " ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) " }

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{ "id": "2981", "sentence": "Lack of T-cell-mediated recognition of the fusion region of the pml/RAR-alpha hybrid protein by lymphocytes of acute promyelocytic leukemia patients .", "label": " ( protein: pml/RAR-alpha hybrid protein, None) , ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: pml/RAR-alpha hybrid protein, None) , ( cell type: lymphocytes, None) " }

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{ "id": "2982", "sentence": "In previous studies, it was shown that the fusion region of the pml/RAR-alpha protein , expressed by acute promyelocytic leukemia (APL) cells , can be specifically recognized in vitro by donor (D. E.) CD4 T cells in a HLA class II DR11-restricted fashion .", "label": " ( cell line: CD4 T cells, None) , ( protein: HLA class II, None) , ( protein: pml/RAR-alpha protein, None) , ( cell line: acute promyelocytic leukemia (APL) cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: CD4 T cells, None) , ( protein: HLA class II, None) , ( protein: pml/RAR-alpha protein, None) , ( cell line: acute promyelocytic leukemia (APL) cells, None) " }

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{ "id": "2983", "sentence": "We present here the results on the recognition of several pml/RAR-alpha peptides by APL patients expressing HLA DR11 .", "label": " ( protein: HLA DR11, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HLA DR11, None) " }

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{ "id": "2984", "sentence": "The in vitro immunization of peripheral blood lymphocytes from four patients in remission (S.R., F.R., M.M., P. G.) with BCR1/25 , a 25-mer pml/ RAR-alpha , did not elicit either a polyclonal or a clonal immune response specific to the peptide .", "label": " ( protein: RAR-alpha, None) , ( cell type: peripheral blood lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RAR-alpha, None) , ( cell type: peripheral blood lymphocytes, None) " }

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{ "id": "2985", "sentence": "We then generated new donor anti-pml/ RAR-alpha CD4(+) T-cell clones .", "label": " ( cell line: anti-pml/ RAR-alpha CD4(+) T-cell clones, None) , ( protein: RAR-alpha, None) , ( protein: anti-pml/ RAR-alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: anti-pml/ RAR-alpha CD4(+) T-cell clones, None) , ( protein: RAR-alpha, None) , ( protein: anti-pml/ RAR-alpha, None) " }

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{ "id": "2986", "sentence": "These clones were tested for their recognition of BCR1/25 .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2987", "sentence": "One clone ( C3/5, CD3(+), CD4(+), CD8(-) ) was selected for further analysis.", "label": " ( cell line: C3/5, CD3(+), CD4(+), CD8(-), None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: C3/5, CD3(+), CD4(+), CD8(-), None) " }

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{ "id": "2988", "sentence": "Clone C3/5 showed specific proliferation, cytotoxicity, and cytokine ( tumor necrosis factor alpha , granulocyte-macrophage colony-stimulating factor ) production when challenged with autologous lymphoblastic cell lines pulsed with peptide BCR1/25 .", "label": " ( cell line: Clone C3/5, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( cell line: autologous lymphoblastic cell lines, None) , ( protein: tumor necrosis factor alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Clone C3/5, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( cell line: autologous lymphoblastic cell lines, None) , ( protein: tumor necrosis factor alpha, None) " }

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{ "id": "2989", "sentence": "C3/5 cells developed specific proliferation and cytotoxicity when challenged with peptide-pulsed lymphoblastic cell lines and peripheral blood lymphocytes from the four DR11(+) APL patients .", "label": " ( cell line: C3/5 cells, None) , ( cell type: peripheral blood lymphocytes, None) , ( cell line: peptide-pulsed lymphoblastic cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: C3/5 cells, None) , ( cell type: peripheral blood lymphocytes, None) , ( cell line: peptide-pulsed lymphoblastic cell lines, None) " }

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{ "id": "2990", "sentence": "APL blasts , available only from patients F.R. and P.G., were not lysed by C3/5 and were unable to present peptide BCR1/25 .", "label": " ( cell line: C3/5, None) , ( cell type: APL blasts, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: C3/5, None) , ( cell type: APL blasts, None) " }

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{ "id": "2991", "sentence": "Incubation of APL cells with IFN-gamma failed to induce HLA class II molecules and recognition by the C3/5 clone .", "label": " ( protein: IFN-gamma, None) , ( cell line: C3/5 clone, None) , ( protein: HLA class II molecules, None) , ( cell line: APL cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN-gamma, None) , ( cell line: C3/5 clone, None) , ( protein: HLA class II molecules, None) , ( cell line: APL cells, None) " }

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{ "id": "2992", "sentence": "Since APL cells do not express HLA class II molecules , we tested in two donors (D.E. and C.H.R.) and in patients S.R.and P.G.whether the use of 9-mer peptides ( BCR1/9 ) would generate a CD8 /HLA class I -restricted response .", "label": " ( protein: CD8, None) , ( protein: /HLA class I, None) , ( protein: HLA class II molecules, None) , ( cell line: APL cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD8, None) , ( protein: /HLA class I, None) , ( protein: HLA class II molecules, None) , ( cell line: APL cells, None) " }

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{ "id": "2993", "sentence": "No peptide-specific T-cell line or clone could be generated from both donors and patients .", "label": " ( cell line: peptide-specific T-cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: peptide-specific T-cell line, None) " }

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{ "id": "2994", "sentence": "These findings are discussed in relation to possible therapeutic approaches to the immunotherapy of APL .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2995", "sentence": "The proximal regulatory element of the interferon-gamma promoter mediates selective expression in T cells .", "label": " ( protein: interferon-gamma, None) , ( DNA: interferon-gamma promoter, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interferon-gamma, None) , ( DNA: interferon-gamma promoter, None) , ( cell type: T cells, None) " }

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{ "id": "2996", "sentence": "Interferon-gamma ( IFN-gamma ) is produced by natural killer cells and certain subsets of T cells , but the basis for its selective expression is unknown.", "label": " ( protein: Interferon-gamma, None) , ( cell type: natural killer cells, None) , ( cell type: T cells, None) , ( protein: IFN-gamma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Interferon-gamma, None) , ( cell type: natural killer cells, None) , ( cell type: T cells, None) , ( protein: IFN-gamma, None) " }

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{ "id": "2997", "sentence": "Within the region between -108 and -40 base pairs of the IFN-gamma promoter are two conserved and essential regulatory elements , which confer activation-specific expression in T cells .", "label": " ( protein: IFN-gamma, None) , ( DNA: regulatory elements, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN-gamma, None) , ( DNA: regulatory elements, None) , ( cell type: T cells, None) " }

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{ "id": "2998", "sentence": "This report describes studies indicating that the most proximal of these two regulatory elements is an important determinant of its restricted expression .", "label": " ( DNA: regulatory elements, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: regulatory elements, None) " }

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{ "id": "2999", "sentence": "The proximal element is a composite site that binds members of the CREB/ATF , AP-1 , and octamer families of transcription factors .", "label": " ( protein: AP-1, None) , ( protein: transcription factors, None) , ( protein: CREB/ATF, None) , ( protein: octamer families, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( protein: transcription factors, None) , ( protein: CREB/ATF, None) , ( protein: octamer families, None) " }