Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "3300", "sentence": "Regions of low base order-dependent stem-loop potential in the region of the gene are defined.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3301", "sentence": "These indicate where base order has been adapted for purposes other than stem-loop stability (e.g., encoding proteins or gene regulation ).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3302", "sentence": "Regions of low potential in a 68.5-kb genomic segment containing the FOSB gene suggest that the potential may help locate genes in uncharted DNA sequences .", "label": " ( DNA: FOSB, None) , ( DNA: uncharted DNA sequences, None) , ( DNA: FOSB gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: FOSB, None) , ( DNA: uncharted DNA sequences, None) , ( DNA: FOSB gene, None) " }

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{ "id": "3303", "sentence": "Susceptibility to natural killer cells and down regulation of MHC class I expression in adenovirus 12 transformed cells are regulated by different E1A domains .", "label": " ( cell line: adenovirus 12 transformed cells, None) , ( DNA: E1A domains, None) , ( protein: MHC, None) , ( cell type: natural killer cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: adenovirus 12 transformed cells, None) , ( DNA: E1A domains, None) , ( protein: MHC, None) , ( cell type: natural killer cells, None) " }

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{ "id": "3304", "sentence": "All human adenoviruses transform rodent cells in vitro, but only cells transformed by serotypes belonging to subgroups A ( Ad12 ) and B ( Ad3 ) are tumorigenic for immunocompetent animals .", "label": " ( cell type: rodent cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: rodent cells, None) " }

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{ "id": "3305", "sentence": "In these cells, the expression of MHC-class I antigens is repressed and might allow them to escape from recognition by cytotoxic T lymphocytes ( CTL ) and to develop in tumor .", "label": " ( cell type: cytotoxic T lymphocytes, None) , ( cell type: CTL, None) , ( protein: MHC-class I antigens, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: cytotoxic T lymphocytes, None) , ( cell type: CTL, None) , ( protein: MHC-class I antigens, None) " }

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{ "id": "3306", "sentence": "Furthermore, these cell lines appear resistant to lysis by natural killer (NK) cells .", "label": " ( cell line: cell lines, None) , ( cell type: natural killer (NK) cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: cell lines, None) , ( cell type: natural killer (NK) cells, None) " }

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{ "id": "3307", "sentence": "To determine the E1A domain (s) responsible for these properties several cell lines were created by transforming baby rat kidney (BRK) cells with a set of plasmids expressing different Ad2/Ad12 hybrid E1A gene products .", "label": " ( cell line: baby rat kidney (BRK) cells, None) , ( DNA: E1A domain, None) , ( protein: Ad2/Ad12 hybrid E1A gene products, None) , ( DNA: plasmids, None) , ( cell line: cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: baby rat kidney (BRK) cells, None) , ( DNA: E1A domain, None) , ( protein: Ad2/Ad12 hybrid E1A gene products, None) , ( DNA: plasmids, None) , ( cell line: cell lines, None) " }

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{ "id": "3308", "sentence": "The MHC class 1 gene expression was inhibited in cells expressing the Ad12 13S mRNA product and in cells transformed with Ad2/Ad12 hybrid E1A gene product harboring the C-terminal part of the conserved region (CR) 3 of Ad12 .", "label": " ( DNA: MHC class 1 gene, None) , ( protein: Ad2/Ad12 hybrid E1A gene product, None) , ( RNA: Ad12 13S mRNA, None) , ( DNA: conserved region (CR) 3, None) , ( protein: Ad12 13S mRNA product, None) , ( protein: C-terminal part, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: MHC class 1 gene, None) , ( protein: Ad2/Ad12 hybrid E1A gene product, None) , ( RNA: Ad12 13S mRNA, None) , ( DNA: conserved region (CR) 3, None) , ( protein: Ad12 13S mRNA product, None) , ( protein: C-terminal part, None) " }

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{ "id": "3309", "sentence": "Susceptibility of these transformed cell lines to NK cells was determined by cytolytic assays.", "label": " ( cell type: NK cells, None) , ( cell line: cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: NK cells, None) , ( cell line: cell lines, None) " }

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{ "id": "3310", "sentence": "The results obtained suggest that two Ad12 E1A domains are required to induce resistance of the cell lines to NK cells .", "label": " ( cell type: NK cells, None) , ( DNA: E1A domains, None) , ( DNA: Ad12 E1A domains, None) , ( cell line: cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: NK cells, None) , ( DNA: E1A domains, None) , ( DNA: Ad12 E1A domains, None) , ( cell line: cell lines, None) " }

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{ "id": "3311", "sentence": "Cell specific expression of human Bruton's agammaglobulinemia tyrosine kinase gene ( Btk ) is regulated by Sp1- and Spi-1/PU.1-family members .", "label": " ( protein: Sp1-, None) , ( protein: Btk, None) , ( protein: Spi-1/PU.1-family members, None) , ( DNA: human Bruton#$%#s agammaglobulinemia tyrosine kinase gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Sp1-, None) , ( protein: Btk, None) , ( protein: Spi-1/PU.1-family members, None) , ( DNA: human Bruton#$%#s agammaglobulinemia tyrosine kinase gene, None) " }

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{ "id": "3312", "sentence": "Bruton's agammaglobulinemia tyrosine kinase ( Btk ) is a cytoplasmic tyrosine kinase involved in the human disease X-linked agammaglobulinemia ( XLA ).", "label": " ( protein: Btk, None) , ( protein: cytoplasmic tyrosine kinase, None) , ( protein: Bruton#$%#s agammaglobulinemia tyrosine kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Btk, None) , ( protein: cytoplasmic tyrosine kinase, None) , ( protein: Bruton#$%#s agammaglobulinemia tyrosine kinase, None) " }

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{ "id": "3313", "sentence": "The gene is expressed in all hematopoietic cells with the exception of T-cells and plasma cells .", "label": " ( cell type: hematopoietic cells, None) , ( cell type: T-cells, None) , ( cell type: plasma cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: hematopoietic cells, None) , ( cell type: T-cells, None) , ( cell type: plasma cells, None) " }

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{ "id": "3314", "sentence": "For this expression pattern the first 280 bp upstream of the major transcriptional start site seems to be sufficient.", "label": " ( DNA: major transcriptional start site, None) , ( DNA: 280 bp upstream, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: major transcriptional start site, None) , ( DNA: 280 bp upstream, None) " }

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{ "id": "3315", "sentence": "In vitro footprinting analysis within this part of the promoter revealed two Sp1 binding sites as well as a PU-box .", "label": " ( DNA: Sp1 binding sites, None) , ( DNA: promoter, None) , ( DNA: PU-box, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Sp1 binding sites, None) , ( DNA: promoter, None) , ( DNA: PU-box, None) " }

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{ "id": "3316", "sentence": "The transcription factor Spi-1/PU.1 as well as the closely related factor Spi-B bound to the PU-box in B-cells.", "label": " ( DNA: PU-box, None) , ( protein: transcription factor, None) , ( protein: Spi-1/PU.1, None) , ( protein: Spi-B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: PU-box, None) , ( protein: transcription factor, None) , ( protein: Spi-1/PU.1, None) , ( protein: Spi-B, None) " }

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{ "id": "3317", "sentence": "In the erythroleukemia cell line K562 , due to the absence of Spi-B , only PU.1 bound to the Btk promoter .", "label": " ( protein: Btk, None) , ( protein: PU.1, None) , ( protein: Spi-B, None) , ( DNA: Btk promoter, None) , ( cell line: erythroleukemia cell line K562, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Btk, None) , ( protein: PU.1, None) , ( protein: Spi-B, None) , ( DNA: Btk promoter, None) , ( cell line: erythroleukemia cell line K562, None) " }

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{ "id": "3318", "sentence": "Mutation of either site reduced the expression in transient transfection experiments.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3319", "sentence": "However, mutation of the PU box had no effect in the T-cell line Jurkat , where none of the Spi-1 family members is expressed.", "label": " ( protein: Spi-1 family members, None) , ( DNA: PU box, None) , ( cell line: T-cell line Jurkat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Spi-1 family members, None) , ( DNA: PU box, None) , ( cell line: T-cell line Jurkat, None) " }

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{ "id": "3320", "sentence": "In addition Spi-B as well as PU.1 were able to transactivate Btk expression .", "label": " ( protein: PU.1, None) , ( protein: Btk, None) , ( protein: Spi-B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PU.1, None) , ( protein: Btk, None) , ( protein: Spi-B, None) " }

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{ "id": "3321", "sentence": "In fetal liver of PU.1-/- mice , which lack lymphoid and myeloid cells , expression of Btk was reduced two- to threefold but not abolished.", "label": " ( protein: Btk, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Btk, None) " }

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{ "id": "3322", "sentence": "Collectively this study shows that expression of the Btk gene is regulated by the combined action of Sp1- and PU.1- family members .", "label": " ( protein: Btk, None) , ( DNA: Btk gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Btk, None) , ( DNA: Btk gene, None) " }

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{ "id": "3323", "sentence": "T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis .", "label": " ( protein: Epstein-Barr virus transactivators, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Epstein-Barr virus transactivators, None) " }

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{ "id": "3324", "sentence": "Rheumatoid arthritis is a multistep disorder associated with autoimmune features of yet unknown etiology .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3325", "sentence": "Implication of viruses such as Epstein-Barr virus ( EBV ) in rheumatoid arthritis pathogenesis has been suspected on the basis of several indirect observations, but thus far, a direct link between EBV and rheumatoid arthritis has not been provided.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3326", "sentence": "Here we show that a large fraction of T cells infiltrating affected joints from a patient with chronic rheumatoid arthritis recognizes two EBV transactivators ( BZLF1 and BMLF1 ) in a major histocompatibility complex -restricted fashion .", "label": " ( protein: major histocompatibility complex, None) , ( cell type: T cells, None) , ( protein: BMLF1, None) , ( protein: EBV transactivators, None) , ( protein: BZLF1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: major histocompatibility complex, None) , ( cell type: T cells, None) , ( protein: BMLF1, None) , ( protein: EBV transactivators, None) , ( protein: BZLF1, None) " }

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{ "id": "3327", "sentence": "Responses to these EBV antigens by synovial lymphocytes from several other chronic rheumatoid arthritis patients were readily detectable.", "label": " ( protein: EBV antigens, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: EBV antigens, None) " }

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{ "id": "3328", "sentence": "Thus these results suggest a direct contribution of EBV to chronic rheumatoid arthritis pathogenesis.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3329", "sentence": "They also demonstrate for the first time the occurrence of T cell responses against EBV transactivating factors , which might be central in the control of virus reactivation .", "label": " ( protein: EBV transactivating factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: EBV transactivating factors, None) " }

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{ "id": "3330", "sentence": "CD14 -mediated signal pathway of Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts .", "label": " ( cell type: human gingival fibroblasts, None) , ( protein: CD14, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human gingival fibroblasts, None) , ( protein: CD14, None) " }

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{ "id": "3331", "sentence": "Lipopolysaccharide ( LPS ) induces expression of inflammatory cytokines in monocytes/macrophages via CD14 , one of the LPS receptors , which is expressed predominantly in these cells.", "label": " ( protein: LPS receptors, None) , ( protein: inflammatory cytokines, None) , ( protein: CD14, None) , ( cell type: monocytes/macrophages, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LPS receptors, None) , ( protein: inflammatory cytokines, None) , ( protein: CD14, None) , ( cell type: monocytes/macrophages, None) " }

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{ "id": "3332", "sentence": "It has been demonstrated that Porphyromonas gingivalis LPS ( P- LPS ) also is able to induce inflammatory cytokines in human gingival fibroblasts .", "label": " ( cell type: human gingival fibroblasts, None) , ( protein: inflammatory cytokines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human gingival fibroblasts, None) , ( protein: inflammatory cytokines, None) " }

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{ "id": "3333", "sentence": "Therefore, it is important to determine whether CD14 is expressed in gingival fibroblasts and to define the P- LPS -mediated signal-transducing mechanism in the cells.", "label": " ( protein: signal-transducing, None) , ( protein: CD14, None) , ( cell type: gingival fibroblasts, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: signal-transducing, None) , ( protein: CD14, None) , ( cell type: gingival fibroblasts, None) " }

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{ "id": "3334", "sentence": "In this study, we observed unexpectedly by immunohistochemical, Western blotting ( immunoblotting ), and Northern (RNA) blotting assays that CD14 is expressed at high density in human gingival fibroblasts .", "label": " ( cell type: human gingival fibroblasts, None) , ( protein: CD14, None) , ( cell type: gingival fibroblasts, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human gingival fibroblasts, None) , ( protein: CD14, None) , ( cell type: gingival fibroblasts, None) " }

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{ "id": "3335", "sentence": "P- LPS -induced expression of the monocyte chemoattractant protein 1 ( MCP-1 ) gene in the cells was inhibited markedly by treatment with anti-human CD14 antibody and was completely inhibited by herbimycin A , a potent inhibitor of tyrosine kinase .", "label": " ( DNA: MCP-1, None) , ( protein: CD14, None) , ( protein: tyrosine kinase, None) , ( protein: monocyte chemoattractant protein 1, None) , ( DNA: monocyte chemoattractant protein 1 ( MCP-1 ) gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: MCP-1, None) , ( protein: CD14, None) , ( protein: tyrosine kinase, None) , ( protein: monocyte chemoattractant protein 1, None) , ( DNA: monocyte chemoattractant protein 1 ( MCP-1 ) gene, None) " }

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{ "id": "3336", "sentence": "The inhibitor also dramatically inhibited monocyte chemotactic activity of and MCP-1 production by the cells.", "label": " ( protein: MCP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MCP-1, None) " }

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{ "id": "3337", "sentence": "Furthermore, P- LPS -induced expression of the MCP-1 gene in the cells also was blocked by inhibitors of two transcription factors , i.e., curcumin , an inhibitor of AP-1 , and pyrolidine dithiocarbamate , an inhibitor of NF-kappaB .", "label": " ( DNA: MCP-1 gene, None) , ( protein: AP-1, None) , ( protein: NF-kappaB, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: MCP-1 gene, None) , ( protein: AP-1, None) , ( protein: NF-kappaB, None) , ( protein: transcription factors, None) " }

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{ "id": "3338", "sentence": "Both inhibitors inhibited monocyte chemotactic activity in the culture supernatant of P- LPS -treated cells.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3339", "sentence": "Gel shift mobility assay showed stimulation of the AP-1 and NF-kappaB contents in P- LPS -treated cells.", "label": " ( protein: AP-1, None) , ( protein: NF-kappaB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( protein: NF-kappaB, None) " }

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{ "id": "3340", "sentence": "This study is the first to demonstrate the expression of CD14 in human gingival fibroblasts and to show that the signal-transducing pathway of P- LPS in the cells is mediated by CD14 .", "label": " ( protein: CD14, None) , ( protein: CD14, None) , ( cell type: human gingival fibroblasts, None) , ( cell type: gingival fibroblasts, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD14, None) , ( protein: CD14, None) , ( cell type: human gingival fibroblasts, None) , ( cell type: gingival fibroblasts, None) " }

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{ "id": "3341", "sentence": "rel Is rapidly tyrosine-phosphorylated following granulocyte-colony stimulating factor treatment of human neutrophils.", "label": " ( protein: rel, None) , ( protein: granulocyte-colony stimulating factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: rel, None) , ( protein: granulocyte-colony stimulating factor, None) " }

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{ "id": "3342", "sentence": "Stimulation of neutrophils with granulocyte-colony stimulating factor ( G-CSF ) results in an enhanced respiratory burst , prolonged survival, and increased tumor cell killing .", "label": " ( protein: G-CSF, None) , ( protein: granulocyte-colony stimulating factor, None) , ( cell type: neutrophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: G-CSF, None) , ( protein: granulocyte-colony stimulating factor, None) , ( cell type: neutrophils, None) " }

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{ "id": "3343", "sentence": "The effects of G-CSF are mediated by binding to specific, high affinity receptors .", "label": " ( protein: affinity receptors, None) , ( protein: G-CSF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: affinity receptors, None) , ( protein: G-CSF, None) " }

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{ "id": "3344", "sentence": "G-CSF receptors lack intrinsic tyrosine kinase activity , but activation of the receptor results in the rapid induction of tyrosine kinase activity .", "label": " ( protein: G-CSF, None) , ( protein: G-CSF receptors, None) , ( protein: tyrosine kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: G-CSF, None) , ( protein: G-CSF receptors, None) , ( protein: tyrosine kinase, None) " }

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{ "id": "3345", "sentence": "Antiphosphotyrosine immunoblots of whole cell lysates prepared from neutrophils show that the G-CSF rapidly induces prominent tyrosine phosphorylation of a protein of a relative molecular mass of 80 kDa.", "label": " ( protein: G-CSF, None) , ( cell type: neutrophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: G-CSF, None) , ( cell type: neutrophils, None) " }

[]

{ "id": "3346", "sentence": "Using monospecific antibodies , the 80-kDa tyrosine -phosphorylated protein has been shown to be p80c-rel , a proto-oncogene belonging to a family of transcriptional regulators which include NF-kB .", "label": " ( protein: monospecific antibodies, None) , ( DNA: proto-oncogene, None) , ( protein: p80c-rel, None) , ( protein: NF-kB, None) , ( protein: transcriptional regulators, None) , ( protein: tyrosine -phosphorylated protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: monospecific antibodies, None) , ( DNA: proto-oncogene, None) , ( protein: p80c-rel, None) , ( protein: NF-kB, None) , ( protein: transcriptional regulators, None) , ( protein: tyrosine -phosphorylated protein, None) " }

[]

{ "id": "3347", "sentence": "The induction of tyrosine phosphorylation of p80c-rel was unique to G-CSF in that granulocyte-macrophage colony stimulating factor which also stimulates neutrophils and induces tyrosine phosphorylation does not result in tyrosine phosphorylation of p80c-rel .", "label": " ( protein: p80c-rel, None) , ( protein: granulocyte-macrophage colony stimulating factor, None) , ( protein: p80c-rel, None) , ( protein: G-CSF, None) , ( cell type: neutrophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p80c-rel, None) , ( protein: granulocyte-macrophage colony stimulating factor, None) , ( protein: p80c-rel, None) , ( protein: G-CSF, None) , ( cell type: neutrophils, None) " }

[]

{ "id": "3348", "sentence": "The consequences of p80c-rel tyrosine phosphorylation are not yet known; however, tyrosine -phosphorylated p80c-rel is capable of binding to DNA, and G-CSF stimulation results in an increase in the amount of p80c-rel which binds to DNA.", "label": " ( protein: G-CSF, None) , ( protein: p80c-rel, None) , ( protein: p80c-rel, None) , ( protein: p80c-rel, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: G-CSF, None) , ( protein: p80c-rel, None) , ( protein: p80c-rel, None) , ( protein: p80c-rel, None) " }

[]

{ "id": "3349", "sentence": "These results demonstrate that one of the first biochemical events which occurs in neutrophils following G-CSF stimulation , activation of a tyrosine kinase , leads directly to the tyrosine phosphorylation of p80c-rel .", "label": " ( cell type: neutrophils, None) , ( protein: p80c-rel, None) , ( protein: tyrosine kinase, None) , ( protein: G-CSF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: neutrophils, None) , ( protein: p80c-rel, None) , ( protein: tyrosine kinase, None) , ( protein: G-CSF, None) " }

[]

{ "id": "3350", "sentence": "Thus, the tyrosine kinase activated by G-CSF appears to directly transduce a signal to a protein which functions as a transcriptional regulator .", "label": " ( protein: transcriptional regulator, None) , ( protein: tyrosine kinase, None) , ( protein: G-CSF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcriptional regulator, None) , ( protein: tyrosine kinase, None) , ( protein: G-CSF, None) " }

[]

{ "id": "3351", "sentence": "Patterns of Pan expression and role of Pan proteins in endocrine cell type-specific complex formation .", "label": " ( protein: Pan, None) , ( protein: Pan proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Pan, None) , ( protein: Pan proteins, None) " }

[]

{ "id": "3352", "sentence": "The Pan gene encodes at least two distinct transcripts, Pan-1 and Pan-2 (also known as E47 and E12 , respectively), by the mechanism of alternative RNA splicing.", "label": " ( protein: Pan-1, None) , ( DNA: Pan gene, None) , ( protein: Pan-2, None) , ( protein: E47, None) , ( protein: E12, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Pan-1, None) , ( DNA: Pan gene, None) , ( protein: Pan-2, None) , ( protein: E47, None) , ( protein: E12, None) " }

[]

{ "id": "3353", "sentence": "Northern blot analyses performed on rat and mouse tissues have detected ubiquitously expressed Pan transcripts, but the abundance, distribution, and form of Pan proteins have not been clearly defined.", "label": " ( protein: Pan proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Pan proteins, None) " }

[]

{ "id": "3354", "sentence": "Studies of cell lines representing endocrine , fibroblast , and lymphoid lineages using polyclonal antisera to detect E2A proteins have suggested that significant E2A protein expression is restricted to B-lymphocytes .", "label": " ( cell line: cell lines, None) , ( protein: E2A protein, None) , ( protein: E2A proteins, None) , ( cell type: B-lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: cell lines, None) , ( protein: E2A protein, None) , ( protein: E2A proteins, None) , ( cell type: B-lymphocytes, None) " }

[]

{ "id": "3355", "sentence": "We have developed a monoclonal antibody , Yae , which is specific for Pan/ E2A proteins , and have used the Yae antibody to examine a variety of endocrine and nonendocrine cell lineages for differences in Pan/ E2A protein expression , subcellular localization, and heteromeric complex formation .", "label": " ( protein: E2A protein, None) , ( protein: Yae, None) , ( protein: Pan/ E2A proteins, None) , ( protein: Yae antibody, None) , ( protein: monoclonal antibody, None) , ( protein: E2A proteins, None) , ( protein: Yae, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: E2A protein, None) , ( protein: Yae, None) , ( protein: Pan/ E2A proteins, None) , ( protein: Yae antibody, None) , ( protein: monoclonal antibody, None) , ( protein: E2A proteins, None) , ( protein: Yae, None) " }

[]

{ "id": "3356", "sentence": "In contrast to previous results obtained using polyclonal antiseras to detect Pan/ E2A proteins , we report comparable levels of Pan proteins in GH/PRL- and insulin- producing , B- and T- lymphocyte cells .", "label": " ( protein: Pan proteins, None) , ( protein: E2A proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Pan proteins, None) , ( protein: E2A proteins, None) " }

[]

{ "id": "3357", "sentence": "IEF-1 , a pancreatic beta-cell type-specific complex believed to regulate insulin expression , is demonstrated to consist of at least two distinct species, one of which does not contain Pan molecules .", "label": " ( protein: IEF-1, None) , ( protein: Pan molecules, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IEF-1, None) , ( protein: Pan molecules, None) " }

[]

{ "id": "3358", "sentence": "Although it has been postulated that pituitary endocrine cells and pancreatic endocrine beta-cells share identical Pan/E2A complexes , native-Western analyses of pituitary and endocrine beta-cells detect Pan proteins in distinct cell type-specific complexes .", "label": " ( protein: Pan/E2A complexes, None) , ( cell type: pancreatic endocrine beta-cells, None) , ( protein: Pan proteins, None) , ( cell type: endocrine beta-cells, None) , ( protein: cell type-specific complexes, None) , ( cell type: pituitary endocrine cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Pan/E2A complexes, None) , ( cell type: pancreatic endocrine beta-cells, None) , ( protein: Pan proteins, None) , ( cell type: endocrine beta-cells, None) , ( protein: cell type-specific complexes, None) , ( cell type: pituitary endocrine cells, None) " }

[]

{ "id": "3359", "sentence": "Visualization of the endogenous NF-kappa B p50 subunit in the nucleus of follicular dendritic cells in germinal centers .", "label": " ( protein: endogenous NF-kappa B p50 subunit, None) , ( cell type: follicular dendritic cells, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: endogenous NF-kappa B p50 subunit, None) , ( cell type: follicular dendritic cells, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "3360", "sentence": "NF-kappa B , a 50 kDa/65 kDa (p50/p65) heterodimer , is a ubiquitous transcription factor involved in the positive regulation of various immune genes .", "label": " ( DNA: immune genes, None) , ( protein: NF-kappa B, None) , ( protein: 50 kDa/65 kDa (p50/p65) heterodimer, None) , ( protein: ubiquitous transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: immune genes, None) , ( protein: NF-kappa B, None) , ( protein: 50 kDa/65 kDa (p50/p65) heterodimer, None) , ( protein: ubiquitous transcription factor, None) " }

[]

{ "id": "3361", "sentence": "The aim of this study was to determine whether NF-kappa B is related to a particular cell type and/or differentiation step during immunopoiesis .", "label": " ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) " }

[]

{ "id": "3362", "sentence": "Using in situ hybridization on sections from non HIV hyperplastic lymph nodes , we found that the gene of the 105 kDa precursor of p50 was overexpressed in the light zone of germinal centers , with a network aspect, which suggested the involvement of follicular dendritic cells ( FDC ).", "label": " ( cell type: FDC, None) , ( protein: 105 kDa precursor, None) , ( protein: p50, None) , ( cell type: follicular dendritic cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: FDC, None) , ( protein: 105 kDa precursor, None) , ( protein: p50, None) , ( cell type: follicular dendritic cells, None) " }

[]

{ "id": "3363", "sentence": "By immunohistochemistry , p50 protein was detected in the cytoplasm and nucleus of FDC , confirming the involvement of FDC .", "label": " ( cell type: FDC, None) , ( cell type: FDC, None) , ( protein: p50, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: FDC, None) , ( cell type: FDC, None) , ( protein: p50, None) " }

[]

{ "id": "3364", "sentence": "Furthermore, p50 protein was detected in the cytoplasm of all lymphocytes .", "label": " ( cell type: lymphocytes, None) , ( protein: p50, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphocytes, None) , ( protein: p50, None) " }

[]

{ "id": "3365", "sentence": "Thus, we focused our study on isolated FDC clusters from normal tonsils.", "label": " ( cell type: FDC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: FDC, None) " }

[]

{ "id": "3366", "sentence": "As showed on tissue sections , we detected the p50 in both cytoplasm and nucleus of FDC .", "label": " ( cell type: FDC, None) , ( protein: p50, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: FDC, None) , ( protein: p50, None) " }

[]

{ "id": "3367", "sentence": "Nuclei of lymphocytes from FDC clusters were negative.", "label": " ( cell type: FDC, None) , ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: FDC, None) , ( cell type: lymphocytes, None) " }

[]

{ "id": "3368", "sentence": "We next studied p65 and c-Rel protein expression in FDC clusters.", "label": " ( cell type: FDC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: FDC, None) " }

[]

{ "id": "3369", "sentence": "p65 was detected in the cytoplasm of FDC , whereas nuclei were negative.", "label": " ( cell type: FDC, None) , ( protein: p65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: FDC, None) , ( protein: p65, None) " }

[]

{ "id": "3370", "sentence": "Furthermore, p65 was detected in the nuclei of some lymphocytes .", "label": " ( cell type: lymphocytes, None) , ( protein: p65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphocytes, None) , ( protein: p65, None) " }

[]

{ "id": "3371", "sentence": "c-Rel protein was detected only in the cytoplasm of lymphocytes and not in the nucleus and cytoplasm of FDC .", "label": " ( cell type: lymphocytes, None) , ( protein: c-Rel protein, None) , ( cell type: FDC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphocytes, None) , ( protein: c-Rel protein, None) , ( cell type: FDC, None) " }

[]

{ "id": "3372", "sentence": "Our results indicated that, in the context of T cell-dependent B cell immunopoiesis occurring in FDC clusters, p50 is mainly related to FDC with a massive overexpression in the nuclei , whereas p65 is expressed in a scattered manner in the nuclei of lymphocytes and c-Rel protein exclusively in the cytoplasm of lymphocytes from FDC clusters.", "label": " ( protein: p65, None) , ( protein: p50, None) , ( cell type: lymphocytes, None) , ( cell type: FDC, None) , ( cell type: FDC, None) , ( cell type: FDC, None) , ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p65, None) , ( protein: p50, None) , ( cell type: lymphocytes, None) , ( cell type: FDC, None) , ( cell type: FDC, None) , ( cell type: FDC, None) , ( cell type: lymphocytes, None) " }

[]

{ "id": "3373", "sentence": "These results suggested that the two subunits of NF-kappa B and the c-Rel protein have different roles in different cell types during B cell immunopoiesis .", "label": " ( protein: NF-kappa B, None) , ( protein: c-Rel protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: c-Rel protein, None) " }

[]

{ "id": "3374", "sentence": "Cloning and characterization of NF-ATc and NF-ATp : the cytoplasmic components of NF-AT .", "label": " ( protein: NF-ATp, None) , ( protein: NF-AT, None) , ( protein: NF-ATc, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-ATp, None) , ( protein: NF-AT, None) , ( protein: NF-ATc, None) " }

[]

{ "id": "3375", "sentence": "Present evidence indicates a pathway of signal transmission in T cells that is outlined in figure 1.", "label": " ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) " }

[]

{ "id": "3376", "sentence": "The elevation in intracellular calcium that is induced by interactions at the antigen receptor leads to the activation of the calcium-dependent phosphatase calcineurin .", "label": " ( protein: calcineurin, None) , ( protein: calcium-dependent phosphatase, None) , ( protein: antigen receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: calcineurin, None) , ( protein: calcium-dependent phosphatase, None) , ( protein: antigen receptor, None) " }

[]

{ "id": "3377", "sentence": "This in turn leads to the nuclear association of the cytosolic component of NF-ATc .", "label": " ( protein: NF-ATc, None) , ( protein: cytosolic component, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-ATc, None) , ( protein: cytosolic component, None) " }

[]

{ "id": "3378", "sentence": "The activation of calcineurin and the nuclear import of NF-ATc can both be blocked by cyclosporin A or FK506 in complex with their respective immunophilins .", "label": " ( protein: NF-ATc, None) , ( protein: calcineurin, None) , ( protein: immunophilins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-ATc, None) , ( protein: calcineurin, None) , ( protein: immunophilins, None) " }

[]

{ "id": "3379", "sentence": "Once in the nucleus , NF-ATc interacts with NF-ATn to form an active transcriptional complex .", "label": " ( protein: active transcriptional complex, None) , ( protein: NF-ATc, None) , ( protein: NF-ATn, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: active transcriptional complex, None) , ( protein: NF-ATc, None) , ( protein: NF-ATn, None) " }

[]

{ "id": "3380", "sentence": "NF-ATn is a ubiquitous protein, can be synthesized in response to PMA , and has many similarities to AP-1 .", "label": " ( protein: AP-1, None) , ( protein: NF-ATn, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( protein: NF-ATn, None) " }

[]

{ "id": "3381", "sentence": "The mechanism by which NF-ATc enters the nucleus is unknown, and although it appears to require calcineurin , NF-ATc has not yet been shown to be an in vivo substrate of calcineurin .", "label": " ( protein: calcineurin, None) , ( protein: NF-ATc, None) , ( protein: calcineurin, None) , ( protein: NF-ATc, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: calcineurin, None) , ( protein: NF-ATc, None) , ( protein: calcineurin, None) , ( protein: NF-ATc, None) " }

[]

{ "id": "3382", "sentence": "Alternative mechanisms include the possibility that NF-ATc operates on some cytoplasmic anchor or that other proteins that are controlled by calcineurin carry out the nuclear import of NF-ATc .", "label": " ( protein: calcineurin, None) , ( protein: NF-ATc, None) , ( protein: NF-ATc, None) , ( protein: cytoplasmic anchor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: calcineurin, None) , ( protein: NF-ATc, None) , ( protein: NF-ATc, None) , ( protein: cytoplasmic anchor, None) " }

[]

{ "id": "3383", "sentence": "Although NF-ATp copurifies with NF-ATc , there is as yet no understanding of how NF-ATp is functioning in vivo.", "label": " ( protein: NF-ATp, None) , ( protein: NF-ATc, None) , ( protein: NF-ATp, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-ATp, None) , ( protein: NF-ATc, None) , ( protein: NF-ATp, None) " }

[]

{ "id": "3384", "sentence": "Now that these proteins are purified and cloned, the major goals will be to understand their role and the roles of other family members in thymic development .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3385", "sentence": "Induction of vascular cell adhesion molecule-1 by low-density lipoprotein .", "label": " ( protein: vascular cell adhesion molecule-1, None) , ( protein: low-density lipoprotein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: vascular cell adhesion molecule-1, None) , ( protein: low-density lipoprotein, None) " }

[]

{ "id": "3386", "sentence": "Low-density lipoprotein ( LDL ) is a well-established risk factor for atherosclerosis .", "label": " ( protein: Low-density lipoprotein, None) , ( protein: LDL, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Low-density lipoprotein, None) , ( protein: LDL, None) " }

[]

{ "id": "3387", "sentence": "When endothelial cells are incubated with this lipoprotein in pathophysiologic amounts, the cells are activated.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3388", "sentence": "Among the documented cellular responses to LDL is increased recruitment of monocytes , which are believed to play a major role in promoting intimal plaque formation.", "label": " ( protein: LDL, None) , ( cell type: monocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LDL, None) , ( cell type: monocytes, None) " }

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{ "id": "3389", "sentence": "The findings presented here link an atheogenic lipoprotein , LDL , with the induction of an adhesion molecule important in atherogenesis Human LDL induces the vascular cell adhesion molecule-1 ( VCAM-1 ) transcriptionally with an increase in mRNA levels through activation of the VCAM promoter .", "label": " ( protein: atheogenic lipoprotein, None) , ( DNA: VCAM promoter, None) , ( protein: vascular cell adhesion molecule-1, None) , ( protein: LDL, None) , ( protein: LDL, None) , ( protein: VCAM-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: atheogenic lipoprotein, None) , ( DNA: VCAM promoter, None) , ( protein: vascular cell adhesion molecule-1, None) , ( protein: LDL, None) , ( protein: LDL, None) , ( protein: VCAM-1, None) " }

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{ "id": "3390", "sentence": "This effect is blocked by anti-VCAM antibodies .", "label": " ( protein: anti-VCAM antibodies, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti-VCAM antibodies, None) " }

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{ "id": "3391", "sentence": "After a 2-day incubation in LDL , the binding of NF-kappa B , which is believed to be a key oxidative-stress sensor for VCAM regulation , remains at basal level.", "label": " ( protein: LDL, None) , ( protein: NF-kappa B, None) , ( protein: VCAM, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LDL, None) , ( protein: NF-kappa B, None) , ( protein: VCAM, None) " }

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{ "id": "3392", "sentence": "In contrast, the binding activities of AP-1 and GATA , on the other hand, are increased by LDL .", "label": " ( protein: AP-1, None) , ( protein: LDL, None) , ( protein: GATA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( protein: LDL, None) , ( protein: GATA, None) " }

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{ "id": "3393", "sentence": "Thus, a component of LDL -enhanced endothelial recruitment of monocytes is attributed to VCAM-1 expression , which appears to be mediated through AP-1 and GATA .", "label": " ( cell type: monocytes, None) , ( protein: LDL, None) , ( protein: VCAM-1, None) , ( protein: AP-1, None) , ( protein: GATA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytes, None) , ( protein: LDL, None) , ( protein: VCAM-1, None) , ( protein: AP-1, None) , ( protein: GATA, None) " }

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{ "id": "3394", "sentence": "These data identify LDL as a VCAM -inducer possibly distinct from cytokines and endotoxin .", "label": " ( protein: VCAM, None) , ( protein: LDL, None) , ( protein: cytokines, None) , ( protein: endotoxin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: VCAM, None) , ( protein: LDL, None) , ( protein: cytokines, None) , ( protein: endotoxin, None) " }

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{ "id": "3395", "sentence": "Involvement of nuclear factor-kappa B activation in IgE synthesis in human B cells .", "label": " ( protein: IgE, None) , ( cell type: human B cells, None) , ( protein: nuclear factor-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IgE, None) , ( cell type: human B cells, None) , ( protein: nuclear factor-kappa B, None) " }

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{ "id": "3396", "sentence": "Nuclear factor-kappa B ( NF-kappa B ) is a transcription factor that binds to the consensus DNA sequence in the cis-acting elements of various genes .", "label": " ( protein: NF-kappa B, None) , ( DNA: consensus DNA sequence, None) , ( DNA: various genes, None) , ( protein: Nuclear factor-kappa B, None) , ( DNA: cis-acting elements, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( DNA: consensus DNA sequence, None) , ( DNA: various genes, None) , ( protein: Nuclear factor-kappa B, None) , ( DNA: cis-acting elements, None) " }

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{ "id": "3397", "sentence": "Although NF-kappa B activates the expression of many genes involved in immune and inflammatory responses , little is known about the role of NF-kappa B activation in the induction of IgE synthesis in human B cells .", "label": " ( protein: NF-kappa B, None) , ( cell type: human B cells, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( cell type: human B cells, None) , ( protein: NF-kappa B, None) " }

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{ "id": "3398", "sentence": "Therefore we first examined the participation of NF-kappa B in germline C epsilon transcription in a human Burkitt lymphoma B cell line , DND39 .", "label": " ( protein: NF-kappa B, None) , ( cell line: human Burkitt lymphoma B cell line, None) , ( cell line: germline C epsilon, None) , ( cell line: DND39, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( cell line: human Burkitt lymphoma B cell line, None) , ( cell line: germline C epsilon, None) , ( cell line: DND39, None) " }

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{ "id": "3399", "sentence": "Stimulation of DND39 cells with IL-4 or anti-CD40 monoclonal antibody ( mAb ) activated phosphatidylinositol 3-kinase and subsequently induced nuclear expression of NF-kappa B , which was identified by electrophoretic mobility shift assays .", "label": " ( protein: IL-4, None) , ( cell line: DND39 cells, None) , ( protein: mAb, None) , ( protein: NF-kappa B, None) , ( protein: anti-CD40 monoclonal antibody, None) , ( protein: phosphatidylinositol 3-kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-4, None) , ( cell line: DND39 cells, None) , ( protein: mAb, None) , ( protein: NF-kappa B, None) , ( protein: anti-CD40 monoclonal antibody, None) , ( protein: phosphatidylinositol 3-kinase, None) " }