Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "3000", "sentence": "Jun is essential for activation-induced transcription and binds preferably as a heterodimer with ATF-2 .", "label": " ( protein: Jun, None) , ( protein: ATF-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Jun, None) , ( protein: ATF-2, None) " }

[]

{ "id": "3001", "sentence": "In contrast, CREB appears to dampen transcription from this element.", "label": " ( protein: CREB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CREB, None) " }

[]

{ "id": "3002", "sentence": "The CpG dinucleotide in this element is selectively methylated in Th2 T cells and other cells that do not express IFN-gamma , and methylation markedly reduces transcription factor binding .", "label": " ( protein: transcription factor, None) , ( cell type: Th2 T cells, None) , ( DNA: element, None) , ( protein: IFN-gamma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor, None) , ( cell type: Th2 T cells, None) , ( DNA: element, None) , ( protein: IFN-gamma, None) " }

[]

{ "id": "3003", "sentence": "As a target for DNA methylation and for binding of transcription factors that mediate or impede transcription, this element appears to play a central role in controlling IFN-gamma expression .", "label": " ( protein: IFN-gamma, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN-gamma, None) , ( protein: transcription factors, None) " }

[]

{ "id": "3004", "sentence": "CD40 , but not lipopolysaccharide and anti-IgM stimulation of primary B lymphocytes , leads to a persistent nuclear accumulation of RelB .", "label": " ( protein: anti-IgM, None) , ( protein: RelB, None) , ( cell type: primary B lymphocytes, None) , ( protein: CD40, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti-IgM, None) , ( protein: RelB, None) , ( cell type: primary B lymphocytes, None) , ( protein: CD40, None) " }

[]

{ "id": "3005", "sentence": "In this study we analyzed the effect of CD40 stimulation on the activity and nuclear appearance of Rel/nuclear factor kappaB ( NF-kappaB ) factors in primary murine B lymphocytes .", "label": " ( protein: NF-kappaB, None) , ( protein: Rel/nuclear factor kappaB ( NF-kappaB ) factors, None) , ( protein: CD40, None) , ( cell type: primary murine B lymphocytes, None) , ( protein: Rel/nuclear factor kappaB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappaB, None) , ( protein: Rel/nuclear factor kappaB ( NF-kappaB ) factors, None) , ( protein: CD40, None) , ( cell type: primary murine B lymphocytes, None) , ( protein: Rel/nuclear factor kappaB, None) " }

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{ "id": "3006", "sentence": "We show that triggering of CD40 signaling pathway (s) by CD40 ligands expressed on L cells led to strong activation of an NF-kappaB-controlled beta-globin reporter gene in primary B lymphocytes from transgenic mice .", "label": " ( protein: CD40, None) , ( protein: CD40, None) , ( cell type: primary B lymphocytes, None) , ( DNA: NF-kappaB-controlled beta-globin reporter gene, None) , ( cell type: L cells, None) , ( protein: CD40 ligands, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD40, None) , ( protein: CD40, None) , ( cell type: primary B lymphocytes, None) , ( DNA: NF-kappaB-controlled beta-globin reporter gene, None) , ( cell type: L cells, None) , ( protein: CD40 ligands, None) " }

[]

{ "id": "3007", "sentence": "Analyses of nuclear translocation of individual members of Rel proteins after CD40 induction of primary B cells showed a strong and long-lasting accumulation of RelB and, less pronounced, of c-Rel .", "label": " ( protein: c-Rel, None) , ( protein: Rel proteins, None) , ( cell type: primary B cells, None) , ( protein: RelB, None) , ( protein: CD40, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c-Rel, None) , ( protein: Rel proteins, None) , ( cell type: primary B cells, None) , ( protein: RelB, None) , ( protein: CD40, None) " }

[]

{ "id": "3008", "sentence": "LPS stimulation did not give rise to a persistent nuclear accumulation of RelB and c-Rel , whereas nuclear c-Rel , but not RelB , accumulated after B cell receptor stimulation .", "label": " ( protein: RelB, None) , ( protein: c-Rel, None) , ( protein: c-Rel, None) , ( protein: RelB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RelB, None) , ( protein: c-Rel, None) , ( protein: c-Rel, None) , ( protein: RelB, None) " }

[]

{ "id": "3009", "sentence": "CD40 induced not only nuclear translocation but also de novo synthesis of RelB RNA and protein.", "label": " ( protein: RelB, None) , ( protein: CD40, None) , ( RNA: RelB RNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RelB, None) , ( protein: CD40, None) , ( RNA: RelB RNA, None) " }

[]

{ "id": "3010", "sentence": "S107 plasmacytoma cells , which express CD40 but are defective for the nuclear appearance of p50/p65-NF-kappaB , do not express RelB after CD40 stimulation.", "label": " ( protein: RelB, None) , ( cell line: S107 plasmacytoma cells, None) , ( protein: p50/p65-NF-kappaB, None) , ( protein: CD40, None) , ( protein: CD40, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RelB, None) , ( cell line: S107 plasmacytoma cells, None) , ( protein: p50/p65-NF-kappaB, None) , ( protein: CD40, None) , ( protein: CD40, None) " }

[]

{ "id": "3011", "sentence": "In S107 cells stably transfected with relB genes , stimulation of nuclear RelB translocation by CD40 was observed.", "label": " ( cell line: S107 cells, None) , ( protein: CD40, None) , ( DNA: relB genes, None) , ( protein: RelB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: S107 cells, None) , ( protein: CD40, None) , ( DNA: relB genes, None) , ( protein: RelB, None) " }

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{ "id": "3012", "sentence": "These results indicate that stimulation of CD40 signaling pathways exerts a long-lasting stimulatory effect on both the transcription and nuclear translocation of RelB .", "label": " ( protein: CD40, None) , ( protein: RelB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD40, None) , ( protein: RelB, None) " }

[]

{ "id": "3013", "sentence": "Since LPS and anti-IgM were unable to activate RelB , CD40 appears to trigger a special program of gene expression involved in the proliferation and/or differentiation of B lymphocytes .", "label": " ( cell type: B lymphocytes, None) , ( protein: RelB, None) , ( protein: CD40, None) , ( protein: anti-IgM, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B lymphocytes, None) , ( protein: RelB, None) , ( protein: CD40, None) , ( protein: anti-IgM, None) " }

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{ "id": "3014", "sentence": "Identification and characterization of a leukocyte-specific component of the nuclear body .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3015", "sentence": "The nuclear body ( NB ) is a cellular organelle that is involved in the pathogenesis of acute promyelocytic leukemia and viral infection .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3016", "sentence": "The NB is also a target of antibodies in the serum of patients with the autoimmune disease primary biliary cirrhosis .", "label": " ( protein: antibodies, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: antibodies, None) " }

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{ "id": "3017", "sentence": "In this study, serum from a patient with primary biliary cirrhosis was used to identify a cDNA encoding a novel component of the NB , a 140-kDa protein designated Sp140 .", "label": " ( protein: 140-kDa protein, None) , ( protein: Sp140, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: 140-kDa protein, None) , ( protein: Sp140, None) " }

[]

{ "id": "3018", "sentence": "The predicted amino acid sequence of the amino-terminal portion of Sp140 was similar to Sp100 , a previously identified NB protein .", "label": " ( protein: amino acid sequence, None) , ( protein: amino-terminal portion, None) , ( protein: NB protein, None) , ( protein: Sp100, None) , ( protein: Sp140, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: amino acid sequence, None) , ( protein: amino-terminal portion, None) , ( protein: NB protein, None) , ( protein: Sp100, None) , ( protein: Sp140, None) " }

[]

{ "id": "3019", "sentence": "The carboxyl portion of Sp140 contained a zinc-finger domain and a bromodomain , motifs that are present in proteins regulating gene transcription .", "label": " ( protein: carboxyl portion, None) , ( protein: Sp140, None) , ( protein: bromodomain, None) , ( protein: zinc-finger domain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: carboxyl portion, None) , ( protein: Sp140, None) , ( protein: bromodomain, None) , ( protein: zinc-finger domain, None) " }

[]

{ "id": "3020", "sentence": "High levels of Sp140 mRNA were detected in human spleen and peripheral blood leukocytes , but not other human tissues .", "label": " ( RNA: Sp140 mRNA, None) , ( cell type: peripheral blood leukocytes, None) , ( protein: Sp140, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: Sp140 mRNA, None) , ( cell type: peripheral blood leukocytes, None) , ( protein: Sp140, None) " }

[]

{ "id": "3021", "sentence": "The level of SP140 mRNA in myeloid precursor cell lines HL60 and NB4 markedly increased in response to chemically induced cellular differentiation.", "label": " ( cell line: NB4, None) , ( RNA: SP140 mRNA, None) , ( cell line: myeloid precursor cell lines, None) , ( cell line: HL60, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: NB4, None) , ( RNA: SP140 mRNA, None) , ( cell line: myeloid precursor cell lines, None) , ( cell line: HL60, None) " }

[]

{ "id": "3022", "sentence": "Immunohistochemical techniques were used to demonstrate that SP140 localized to the NB in differentiated HL60 and NB4 cells .", "label": " ( cell line: HL60, None) , ( cell line: NB4 cells, None) , ( protein: SP140, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL60, None) , ( cell line: NB4 cells, None) , ( protein: SP140, None) " }

[]

{ "id": "3023", "sentence": "The location of Sp140 in the NB , and expression of this gene in cells involved in host defense, suggest that Sp140 may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection .", "label": " ( protein: Sp140, None) , ( protein: Sp140, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Sp140, None) , ( protein: Sp140, None) " }

[]

{ "id": "3024", "sentence": "Regulation of cytokine and cytokine receptor expression by glucocorticoids .", "label": " ( protein: cytokine receptor, None) , ( protein: cytokine, None) , ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine receptor, None) , ( protein: cytokine, None) , ( protein: cytokine, None) " }

[]

{ "id": "3025", "sentence": "Glucocorticoids ( GCS ) profoundly inhibit several aspects of T cell immunity largely through inhibition of cytokine expression at the transcriptional and posttranscriptional levels .", "label": " ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine, None) " }

[]

{ "id": "3026", "sentence": "GCS were also reported to act indirectly by inducing transforming growth factor-beta expression , which in turn blocks T cell immunity .", "label": " ( protein: growth factor-beta, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: growth factor-beta, None) " }

[]

{ "id": "3027", "sentence": "In exerting their antiproliferative effects, GCS diffuse into target cells where they bind their cytoplasmic receptor , which in turn translocates to the nucleus where it inhibits transcription of cytokine genes through direct binding to the glucocorticoid response elements ( GRE ), which are located in the promoter region of cytokine genes or, alternatively, through antagonism of the action of transcription factors required for optimal transcriptional activation .", "label": " ( cell type: target cells, None) , ( DNA: glucocorticoid response elements, None) , ( DNA: cytokine genes, None) , ( protein: cytokine, None) , ( DNA: cytokine genes, None) , ( protein: transcription factors, None) , ( protein: cytokine, None) , ( protein: cytoplasmic receptor, None) , ( DNA: GRE, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: target cells, None) , ( DNA: glucocorticoid response elements, None) , ( DNA: cytokine genes, None) , ( protein: cytokine, None) , ( DNA: cytokine genes, None) , ( protein: transcription factors, None) , ( protein: cytokine, None) , ( protein: cytoplasmic receptor, None) , ( DNA: GRE, None) " }

[]

{ "id": "3028", "sentence": "In contrast to their inhibitory effects on cytokine expression , GCS up-regulate cytokine receptor expression that correlates with enhanced cytokine effects on target cells .", "label": " ( protein: cytokine, None) , ( protein: cytokine receptor, None) , ( cell type: target cells, None) , ( protein: cytokine, None) , ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine, None) , ( protein: cytokine receptor, None) , ( cell type: target cells, None) , ( protein: cytokine, None) , ( protein: cytokine, None) " }

[]

{ "id": "3029", "sentence": "In this review, we summarize the current state of knowledge of the mechanism of action of GCS , including the phenomenon of steroid-induced rebound, which ensues upon GCS withdrawal .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3030", "sentence": "Isolation and characterization of murine fra-1 : induction mediated by CD40 and surface Ig is protein kinase C dependent .", "label": " ( protein: surface Ig, None) , ( DNA: murine fra-1, None) , ( protein: protein kinase C, None) , ( protein: CD40, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: surface Ig, None) , ( DNA: murine fra-1, None) , ( protein: protein kinase C, None) , ( protein: CD40, None) " }

[]

{ "id": "3031", "sentence": "The murine fra-1 gene , encoding Fos-related Ag 1 , was isolated from a splenic cDNA library and sequenced.", "label": " ( protein: Fos-related Ag 1, None) , ( DNA: splenic cDNA library, None) , ( DNA: murine fra-1 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Fos-related Ag 1, None) , ( DNA: splenic cDNA library, None) , ( DNA: murine fra-1 gene, None) " }

[]

{ "id": "3032", "sentence": "Murine fra-1 was highly homologous to rat and human fra-1 .", "label": " ( DNA: Murine fra-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Murine fra-1, None) " }

[]

{ "id": "3033", "sentence": "Oligonucleotide primers based on the murine sequence were used to construct a quantitative reverse transcription-PCR assay for gene expression .", "label": " ( DNA: murine sequence, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: murine sequence, None) " }

[]

{ "id": "3034", "sentence": "B lymphocyte stimulation via both CD40 and surface Ig ( sIg ) receptors substantially induced fra-1 expression , and for both receptors, induction was protein kinase C ( PKC ) dependent .", "label": " ( protein: sIg, None) , ( protein: CD40, None) , ( cell type: B lymphocyte, None) , ( protein: protein kinase C, None) , ( DNA: fra-1, None) , ( protein: surface Ig, None) , ( protein: surface Ig ( sIg ) receptors, None) , ( protein: PKC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: sIg, None) , ( protein: CD40, None) , ( cell type: B lymphocyte, None) , ( protein: protein kinase C, None) , ( DNA: fra-1, None) , ( protein: surface Ig, None) , ( protein: surface Ig ( sIg ) receptors, None) , ( protein: PKC, None) " }

[]

{ "id": "3035", "sentence": "This contrasts with induction of c-fos by both CD40 and sIg , which is PKC independent and indicates that CD40 is capable of signaling through PKC or a closely related kinase .", "label": " ( DNA: c-fos, None) , ( protein: PKC, None) , ( protein: kinase, None) , ( protein: sIg, None) , ( protein: CD40, None) , ( protein: CD40, None) , ( protein: PKC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: c-fos, None) , ( protein: PKC, None) , ( protein: kinase, None) , ( protein: sIg, None) , ( protein: CD40, None) , ( protein: CD40, None) , ( protein: PKC, None) " }

[]

{ "id": "3036", "sentence": "Induction of fra-1 following engagement of CD40 did not require protein synthesis , suggesting that the PKC -dependent linkage between CD40 and fra-1 is direct.", "label": " ( protein: CD40, None) , ( DNA: fra-1, None) , ( protein: PKC, None) , ( protein: CD40, None) , ( DNA: fra-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD40, None) , ( DNA: fra-1, None) , ( protein: PKC, None) , ( protein: CD40, None) , ( DNA: fra-1, None) " }

[]

{ "id": "3037", "sentence": "CD40 -mediated fra-1 induction did require tyrosine kinase activity .", "label": " ( protein: tyrosine kinase, None) , ( DNA: fra-1, None) , ( protein: CD40, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tyrosine kinase, None) , ( DNA: fra-1, None) , ( protein: CD40, None) " }

[]

{ "id": "3038", "sentence": "These results demonstrate that CD40 , like sIg , may employ PKC in producing select outcomes, that individual B cell receptors may signal downstream events via both PKC-dependent and PKC-independent pathways , and that multiple signal transduction pathways may be used to activate the expression of closely related genes .", "label": " ( protein: sIg, None) , ( protein: PKC, None) , ( DNA: genes, None) , ( protein: CD40, None) , ( protein: B cell receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: sIg, None) , ( protein: PKC, None) , ( DNA: genes, None) , ( protein: CD40, None) , ( protein: B cell receptors, None) " }

[]

{ "id": "3039", "sentence": "Pentoxifylline for the treatment of infection with human immunodeficiency virus .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3040", "sentence": "Cytokine dysregulation in human immunodeficiency virus type 1 ( HIV-1 ) infection has been documented in numerous studies and has been cited as an important component in the pathogenesis of this retroviral infection .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3041", "sentence": "Pharmacological modification of cytokine dysregulation , therefore, has been suggested as a therapeutic modality for HIV-1 infection .", "label": " ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine, None) " }

[]

{ "id": "3042", "sentence": "Dr. Dezube of Beth Israel Hospital (Boston) concisely reviews the state of our knowledge regarding the effects of pentoxifylline on expression of tumor necrosis factor-alpha , a cytokine known to influence HIV-1 replication and to play a possible role in the clinical manifestations of advanced infection with this virus.", "label": " ( protein: tumor necrosis factor-alpha, None) , ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tumor necrosis factor-alpha, None) , ( protein: cytokine, None) " }

[]

{ "id": "3043", "sentence": "Pentoxifylline , a trisubstituted xanthine derivative , has been used to decrease blood viscosity and is reasonably well tolerated by most recipients of the drug.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3044", "sentence": "Results of preliminary studies, many of which were conducted by Dr. Dezube , suggest that use of this agent in combination with antiretroviral compounds may prove useful in the treatment of patients with HIV-1 infection.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3045", "sentence": "Activation of the granulocyte-macrophage colony-stimulating factor promoter in T cells requires cooperative binding of Elf-1 and AP-1 transcription factors .", "label": " ( protein: AP-1, None) , ( cell type: T cells, None) , ( protein: Elf-1, None) , ( DNA: granulocyte-macrophage colony-stimulating factor promoter, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( cell type: T cells, None) , ( protein: Elf-1, None) , ( DNA: granulocyte-macrophage colony-stimulating factor promoter, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( protein: transcription factors, None) " }

[]

{ "id": "3046", "sentence": "The granulocyte-macrophage colony-stimulating factor ( GM-CSF ) gene has been studied extensively as a model system of transcriptional induction during T-lymphocyte activation .", "label": " ( DNA: granulocyte-macrophage colony-stimulating factor ( GM-CSF ) gene, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( protein: GM-CSF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: granulocyte-macrophage colony-stimulating factor ( GM-CSF ) gene, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( protein: GM-CSF, None) " }

[]

{ "id": "3047", "sentence": "The GM-CSF gene is not expressed in resting peripheral blood T cells but is rapidly induced at the transcriptional level following activation through the cell surface T-cell receptor .", "label": " ( protein: GM-CSF, None) , ( cell type: peripheral blood T cells, None) , ( DNA: GM-CSF gene, None) , ( protein: cell surface T-cell receptor, None) , ( cell type: resting peripheral blood T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GM-CSF, None) , ( cell type: peripheral blood T cells, None) , ( DNA: GM-CSF gene, None) , ( protein: cell surface T-cell receptor, None) , ( cell type: resting peripheral blood T cells, None) " }

[]

{ "id": "3048", "sentence": "A highly conserved 19-bp element located immediately 5' of the human GM-CSF TATA box ( bp -34 to -52 ), herein called purine box 1 ( PB1 ), has been shown to bind a T-cell nuclear protein complex and to be required for transcriptional induction of the GM-CSF gene following T-cell activation .", "label": " ( DNA: bp -34 to -52, None) , ( protein: GM-CSF, None) , ( protein: T-cell nuclear protein complex, None) , ( DNA: human GM-CSF TATA box, None) , ( DNA: GM-CSF gene, None) , ( DNA: purine box 1, None) , ( protein: GM-CSF, None) , ( DNA: PB1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: bp -34 to -52, None) , ( protein: GM-CSF, None) , ( protein: T-cell nuclear protein complex, None) , ( DNA: human GM-CSF TATA box, None) , ( DNA: GM-CSF gene, None) , ( DNA: purine box 1, None) , ( protein: GM-CSF, None) , ( DNA: PB1, None) " }

[]

{ "id": "3049", "sentence": "The PB1 sequence motif is highly conserved in both human and murine GM-CSF genes .", "label": " ( DNA: PB1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: PB1, None) " }

[]

{ "id": "3050", "sentence": "In this report, we demonstrate that the PB1 element alone confers inducibility on a heterologous promoter following transfection into human Jurkat T cells .", "label": " ( DNA: PB1, None) , ( DNA: PB1 element, None) , ( cell line: human Jurkat T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: PB1, None) , ( DNA: PB1 element, None) , ( cell line: human Jurkat T cells, None) " }

[]

{ "id": "3051", "sentence": "In addition, we identify a major PB1 nuclear protein-binding complex that is not present in resting peripheral blood T cells but is rapidly induced following T-cell activation .", "label": " ( protein: PB1 nuclear protein-binding complex, None) , ( cell type: peripheral blood T cells, None) , ( DNA: PB1, None) , ( cell type: resting peripheral blood T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PB1 nuclear protein-binding complex, None) , ( cell type: peripheral blood T cells, None) , ( DNA: PB1, None) , ( cell type: resting peripheral blood T cells, None) " }

[]

{ "id": "3052", "sentence": "Sequence analysis revealed that PB1 is composed of adjacent binding sites for Ets and AP-1 transcription factors .", "label": " ( DNA: PB1, None) , ( DNA: adjacent binding sites, None) , ( protein: Ets, None) , ( protein: AP-1, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: PB1, None) , ( DNA: adjacent binding sites, None) , ( protein: Ets, None) , ( protein: AP-1, None) , ( protein: transcription factors, None) " }

[]

{ "id": "3053", "sentence": "In vitro mutagenesis experiments demonstrated that both the Ets and AP-1 sites are required for binding of the inducible PB1 nuclear protein complex and for the transcriptional activity of this element and the GM-CSF promoter in activated T cells .", "label": " ( cell type: activated T cells, None) , ( DNA: GM-CSF promoter, None) , ( protein: PB1 nuclear protein complex, None) , ( DNA: PB1, None) , ( protein: GM-CSF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: activated T cells, None) , ( DNA: GM-CSF promoter, None) , ( protein: PB1 nuclear protein complex, None) , ( DNA: PB1, None) , ( protein: GM-CSF, None) " }

[]

{ "id": "3054", "sentence": "(ABSTRACT TRUNCATED AT 250 WORDS)", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3055", "sentence": "Steroid-resistant asthma .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3056", "sentence": "Cellular mechanisms contributing to inadequate response to glucocorticoid therapy .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3057", "sentence": "The current study examined whether alterations in glucocorticoid receptor ( GR ) binding contribute to poor response to glucocorticoid therapy in asthma.", "label": " ( protein: glucocorticoid receptor, None) , ( protein: GR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptor, None) , ( protein: GR, None) " }

[]

{ "id": "3058", "sentence": "29 asthma patients with forced expiratory volume in 1 s ( FEV1 ) < 70% predicted were studied.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3059", "sentence": "Patients were classified as steroid sensitive ( SS ) if their morning FEV1 increased > 30% after a 1-wk course of oral prednisone 20 mg twice daily and steroid resistant ( SR ) if they failed to increase > 15%.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3060", "sentence": "PBMC obtained from these two groups, 17 SR and 12 SS , as well as 12 normal controls were analyzed. SR patients had two distinguishable GR binding abnormalities: 15 of the 17 SR patients demonstrated a significantly reduced GR binding affinity , as compared with SS patients (P = 0.0001) and normal controls (P = 0.0001).", "label": " ( protein: GR, None) , ( protein: GR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GR, None) , ( protein: GR, None) " }

[]

{ "id": "3061", "sentence": "This defect was localized to T cells and reverted to normal after 48 h in culture media.", "label": " ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) " }

[]

{ "id": "3062", "sentence": "However, incubation with a combination of IL-2 and IL-4 sustained this abnormality.", "label": " ( protein: IL-2, None) , ( protein: IL-4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( protein: IL-4, None) " }

[]

{ "id": "3063", "sentence": "The other two SR patients had an abnormally low GR number with normal binding affinity that was not limited to T cells .", "label": " ( cell type: T cells, None) , ( protein: GR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: GR, None) " }

[]

{ "id": "3064", "sentence": "Furthermore, GR number failed to normalize after incubation in media alone or IL-2 and IL-4 .", "label": " ( protein: GR, None) , ( protein: IL-4, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GR, None) , ( protein: IL-4, None) , ( protein: IL-2, None) " }

[]

{ "id": "3065", "sentence": "Therefore, SR asthma may be due to more than one abnormality, the majority related to a reversible cytokine -induced reduction in GR binding affinity and the second related to an irreversible reduction in GR number .", "label": " ( protein: cytokine, None) , ( protein: GR, None) , ( protein: GR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine, None) , ( protein: GR, None) , ( protein: GR, None) " }

[]

{ "id": "3066", "sentence": "These findings may have important implications for the design of alternative treatment approaches for recalcitrant asthma .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3067", "sentence": "Prevalence of aneuploidy , overexpressed ER , and overexpressed EGFR in random breast aspirates of women at high and low risk for breast cancer .", "label": " ( protein: ER, None) , ( protein: EGFR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ER, None) , ( protein: EGFR, None) " }

[]

{ "id": "3068", "sentence": "Breast tissue biomarkers which accurately predict breast cancer development within a 10 year period in high risk women are needed but currently not available.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3069", "sentence": "We initiated this study to determine 1) the prevalence of one or more breast tissue abnormalities in a group of women at high risk for breast cancer , and 2) if the prevalence of biomarker abnormalities is greater in high risk than in low risk women .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3070", "sentence": "Eligible high risk women were those with a first degree relative with breast cancer , prior breast cancer , or precancerous mastopathy .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3071", "sentence": "Low risk women were those without these or other major identifiable risk factors .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3072", "sentence": "Ductal cells were obtained via random fine needle aspirations and cytologically classified.", "label": " ( cell type: Ductal cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: Ductal cells, None) " }

[]

{ "id": "3073", "sentence": "Biomarkers included DNA ploidy , estrogen receptor ( ER ), and epidermal growth factor receptor ( EGFR ).", "label": " ( protein: epidermal growth factor receptor, None) , ( protein: estrogen receptor, None) , ( protein: ER, None) , ( protein: EGFR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: epidermal growth factor receptor, None) , ( protein: estrogen receptor, None) , ( protein: ER, None) , ( protein: EGFR, None) " }

[]

{ "id": "3074", "sentence": "The prevalence of DNA aneuploidy was 30%, overexpression of ER 10%, and overexpression of EGFR 35%, in the 206 high risk women whose median 10 year Gail risk (projected probability) of developing breast cancer was 4.5%.", "label": " ( protein: EGFR, None) , ( protein: ER, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: EGFR, None) , ( protein: ER, None) " }

[]

{ "id": "3075", "sentence": "The prevalence of aneuploidy and overexpressed EGFR was significantly higher in the high risk women than in the 25 low risk controls (p < 0.002), whose median 10 year Gail risk was 0.7%.", "label": " ( protein: EGFR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: EGFR, None) " }

[]

{ "id": "3076", "sentence": "The difference in the prevalence of ER overexpression between high and low risk groups was not statistically significant (p = 0.095).", "label": " ( protein: ER, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ER, None) " }

[]

{ "id": "3077", "sentence": "This may be due to the low prevalence of overexpressed ER and the small number of controls.", "label": " ( protein: ER, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ER, None) " }

[]

{ "id": "3078", "sentence": "A significant difference was noted in the prevalence of one or more abnormal biomarkers between the high risk and low risk women (p < 0.001).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3079", "sentence": "A large prospective trial is needed to determine if one or more of these biomarkers , is predictive of breast cancer development .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3080", "sentence": "Inhibition of nuclear factor kappa B subunit p65 mRNA accumulation in lipopolysaccharide -stimulated human monocytic cells treated with sodium salicylate .", "label": " ( RNA: nuclear factor kappa B subunit p65 mRNA, None) , ( protein: nuclear factor kappa B, None) , ( protein: nuclear factor kappa B subunit p65, None) , ( cell line: lipopolysaccharide -stimulated human monocytic cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: nuclear factor kappa B subunit p65 mRNA, None) , ( protein: nuclear factor kappa B, None) , ( protein: nuclear factor kappa B subunit p65, None) , ( cell line: lipopolysaccharide -stimulated human monocytic cells, None) " }

[]

{ "id": "3081", "sentence": "Lipopolysaccharide is one of the most potent trigger substances for monocytes and macrophages causing secretion of inflammatory mediators such as tumor necrosis factor and interleukin-1 .", "label": " ( protein: interleukin-1, None) , ( protein: inflammatory mediators, None) , ( protein: tumor necrosis factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin-1, None) , ( protein: inflammatory mediators, None) , ( protein: tumor necrosis factor, None) " }

[]

{ "id": "3082", "sentence": "The nature of the nuclear factors involved in regulation of these cytokine genes is still unknown.", "label": " ( protein: cytokine, None) , ( DNA: cytokine genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine, None) , ( DNA: cytokine genes, None) " }

[]

{ "id": "3083", "sentence": "Nuclear factor kappa B ( NF-kappa B ; heterodimer of p50 and p65 ) proteins have been suggested to play an important role in gene transcription of inflammatory mediators when monocytes are stimulated with lipopolysaccharide .", "label": " ( protein: p65, None) , ( protein: NF-kappa B, None) , ( protein: Nuclear factor kappa B, None) , ( protein: inflammatory mediators, None) , ( cell type: monocytes, None) , ( protein: p50, None) , ( protein: Nuclear factor kappa B ( NF-kappa B ; heterodimer of p50 and p65 ) proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p65, None) , ( protein: NF-kappa B, None) , ( protein: Nuclear factor kappa B, None) , ( protein: inflammatory mediators, None) , ( cell type: monocytes, None) , ( protein: p50, None) , ( protein: Nuclear factor kappa B ( NF-kappa B ; heterodimer of p50 and p65 ) proteins, None) " }

[]

{ "id": "3084", "sentence": "Nonsteroidal anti-inflammatory drugs such as salicylates have been used to treat symptoms of inflammation , and a new mechanism of drug action was suggested recently.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3085", "sentence": "Salicylates have been shown to inhibit lipopolysaccharide -induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor \" I kappa B \", blocking the translocation of NF-kappa B into the nuclear compartment .", "label": " ( protein: NF-kappa B, None) , ( protein: NF-kappa B inhibitor, None) , ( protein: NF-kappa B, None) , ( protein: I kappa B, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: NF-kappa B inhibitor, None) , ( protein: NF-kappa B, None) , ( protein: I kappa B, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "3086", "sentence": "However, the nature of the subunit involved in this mechanism has not been defined.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3087", "sentence": "To examine the mechanisms by which salicylates affect cytokine gene transcription , the amount of active and inactive NF-kappa B and NF-kappa B mRNA , in Porphyromonas gingivalis lipopolysaccharide -stimulated human monocytic cells was assessed.", "label": " ( cell line: lipopolysaccharide -stimulated human monocytic cells, None) , ( protein: NF-kappa B, None) , ( protein: cytokine, None) , ( RNA: NF-kappa B mRNA, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: lipopolysaccharide -stimulated human monocytic cells, None) , ( protein: NF-kappa B, None) , ( protein: cytokine, None) , ( RNA: NF-kappa B mRNA, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "3088", "sentence": "High doses of sodium salicylate suppressed NF-kappa B p65 mRNA accumulation , resulting in suppression of total NF-kappa B , p50 on tissue oligonucleotide had no effects on lipopolysaccharide -induced NF-kappa B activation .", "label": " ( protein: p50, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( RNA: p65 mRNA, None) , ( protein: p65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p50, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( RNA: p65 mRNA, None) , ( protein: p65, None) " }

[]

{ "id": "3089", "sentence": "The data demonstrate that the p65 subunit of NF-kappa B is inhibited by salicylate treatment and highlight the role of salicylate in the control of gene expression of inflammatory mediators .", "label": " ( protein: NF-kappa B, None) , ( protein: inflammatory mediators, None) , ( protein: p65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: inflammatory mediators, None) , ( protein: p65, None) " }

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{ "id": "3090", "sentence": "Glucocorticoid -mediated inhibition of RANTES expression in human T lymphocytes .", "label": " ( protein: RANTES, None) , ( cell type: human T lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RANTES, None) , ( cell type: human T lymphocytes, None) " }

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{ "id": "3091", "sentence": "The chemokine RANTES has been implicated in the pathogenesis of allergic inflammatory diseases including asthma and rhinitis which are frequently treated with glucocorticoids .", "label": " ( protein: RANTES, None) , ( protein: chemokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RANTES, None) , ( protein: chemokine, None) " }

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{ "id": "3092", "sentence": "We observed that dexamethasone dramatically inhibited RANTES mRNA expression dose dependently in anti-CD3 activated Hut-78 T cells and human PBMCs .", "label": " ( cell type: human PBMCs, None) , ( protein: RANTES, None) , ( RNA: RANTES mRNA, None) , ( cell line: anti-CD3 activated Hut-78 T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human PBMCs, None) , ( protein: RANTES, None) , ( RNA: RANTES mRNA, None) , ( cell line: anti-CD3 activated Hut-78 T cells, None) " }

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{ "id": "3093", "sentence": "Inhibition of RANTES expression did not appear to be secondary to IL-2 inhibition and required binding to the intracellular glucocorticoid receptor .", "label": " ( protein: RANTES, None) , ( protein: IL-2, None) , ( protein: glucocorticoid receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RANTES, None) , ( protein: IL-2, None) , ( protein: glucocorticoid receptor, None) " }

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{ "id": "3094", "sentence": "The down-regulation of RANTES expression by glucocorticoids in T cells may directly contribute to the efficacy of these agents in suppressing cellular infiltration and to their anti-inflammatory properties .", "label": " ( cell type: T cells, None) , ( protein: RANTES, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: RANTES, None) " }

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{ "id": "3095", "sentence": "Association of TRAF1 , TRAF2 , and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation : role in NF-kappaB activation .", "label": " ( cell type: B-lymphocyte, None) , ( protein: NF-kappaB, None) , ( protein: TRAF3, None) , ( protein: TRAF2, None) , ( protein: TRAF1, None) , ( DNA: Epstein-Barr virus LMP1 domain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B-lymphocyte, None) , ( protein: NF-kappaB, None) , ( protein: TRAF3, None) , ( protein: TRAF2, None) , ( protein: TRAF1, None) , ( DNA: Epstein-Barr virus LMP1 domain, None) " }

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{ "id": "3096", "sentence": "The Epstein-Barr virus ( EBV ) transforming protein LMP1 appears to be a constitutively activated tumor necrosis factor receptor ( TNFR ) on the basis of an intrinsic ability to aggregate in the plasma membrane and an association of its cytoplasmic carboxyl terminus ( CT ) with TNFR -associated factors ( TRAFs ).", "label": " ( protein: TNFR, None) , ( protein: Epstein-Barr virus ( EBV ) transforming protein LMP1, None) , ( protein: LMP1, None) , ( protein: transforming protein, None) , ( protein: TRAFs, None) , ( protein: constitutively activated tumor necrosis factor receptor, None) , ( protein: CT, None) , ( protein: TNFR, None) , ( protein: TNFR -associated factors, None) , ( protein: cytoplasmic carboxyl terminus, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNFR, None) , ( protein: Epstein-Barr virus ( EBV ) transforming protein LMP1, None) , ( protein: LMP1, None) , ( protein: transforming protein, None) , ( protein: TRAFs, None) , ( protein: constitutively activated tumor necrosis factor receptor, None) , ( protein: CT, None) , ( protein: TNFR, None) , ( protein: TNFR -associated factors, None) , ( protein: cytoplasmic carboxyl terminus, None) " }

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{ "id": "3097", "sentence": "We now show that in EBV-transformed B lymphocytes most of TRAF1 or TRAF3 and 5% of TRAF2 are associated with LMP1 and that most of LMP1 is associated with TRAF1 or TRAF3 .", "label": " ( cell line: EBV-transformed B lymphocytes, None) , ( protein: TRAF3, None) , ( protein: LMP1, None) , ( protein: TRAF3, None) , ( protein: TRAF2, None) , ( protein: TRAF1, None) , ( protein: TRAF1, None) , ( protein: LMP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: EBV-transformed B lymphocytes, None) , ( protein: TRAF3, None) , ( protein: LMP1, None) , ( protein: TRAF3, None) , ( protein: TRAF2, None) , ( protein: TRAF1, None) , ( protein: TRAF1, None) , ( protein: LMP1, None) " }

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{ "id": "3098", "sentence": "TRAF1 , TRAF2 , and TRAF3 bind to a single site in the LMP1 CT corresponding to amino acids (aa) 199 to 214, within a domain which is important for B-lymphocyte growth transformation (aa 187 to 231).", "label": " ( protein: TRAF3, None) , ( protein: LMP1, None) , ( protein: TRAF2, None) , ( protein: TRAF1, None) , ( protein: LMP1 CT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TRAF3, None) , ( protein: LMP1, None) , ( protein: TRAF2, None) , ( protein: TRAF1, None) , ( protein: LMP1 CT, None) " }

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{ "id": "3099", "sentence": "Further deletional and alanine mutagenesis analyses and comparison with TRAF binding sequences in CD40 , in CD30 , and in the LMP1 of other lymphycryptoviruses provide the first evidence that PXQXT/S is a core TRAF binding motif .", "label": " ( DNA: TRAF binding sequences, None) , ( DNA: TRAF binding motif, None) , ( DNA: PXQXT/S, None) , ( protein: TRAF, None) , ( protein: LMP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: TRAF binding sequences, None) , ( DNA: TRAF binding motif, None) , ( DNA: PXQXT/S, None) , ( protein: TRAF, None) , ( protein: LMP1, None) " }