Datasets:

huy-nh-2000

/

instructUIE

like 0

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{ "id": "1900", "sentence": "It seems therefore that PGE2 , by elevating cAMP levels , interferes with the activation pathway for NF-kappa B but not for NF-AT , AP-1 or CLE0 binding protein .", "label": " ( protein: NF-kappa B, None) , ( protein: PGE2, None) , ( protein: AP-1, None) , ( protein: CLE0 binding protein, None) , ( protein: NF-AT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: PGE2, None) , ( protein: AP-1, None) , ( protein: CLE0 binding protein, None) , ( protein: NF-AT, None) " }

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{ "id": "1901", "sentence": "Characterization of NF(P) , the nuclear factor that interacts with the regulatory P sequence ( 5'-CGAAAATTTCC-3' ) of the human interleukin-4 gene : relationship to NF-kappa B and NF-AT .", "label": " ( protein: nuclear factor, None) , ( protein: NF-kappa B, None) , ( DNA: P sequence, None) , ( protein: NF(P), None) , ( DNA: human interleukin-4 gene, None) , ( protein: NF-AT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor, None) , ( protein: NF-kappa B, None) , ( DNA: P sequence, None) , ( protein: NF(P), None) , ( DNA: human interleukin-4 gene, None) , ( protein: NF-AT, None) " }

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{ "id": "1902", "sentence": "The P sequence of the human interleukin-4 ( IL-4 ) gene , which was defined as a responsive element for phorbol 12-myristate 13-acetate and calcium ionophore ( A23187 ) in Jurkat T cells , shares sequence similarity with the NF-kappa B and the NF-AT binding sites .", "label": " ( DNA: P sequence, None) , ( protein: IL-4, None) , ( DNA: human interleukin-4 ( IL-4 ) gene, None) , ( protein: NF-kappa B, None) , ( DNA: NF-AT binding sites, None) , ( DNA: responsive element, None) , ( DNA: NF-kappa B and the NF-AT binding sites, None) , ( cell line: Jurkat T cells, None) , ( protein: NF-AT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: P sequence, None) , ( protein: IL-4, None) , ( DNA: human interleukin-4 ( IL-4 ) gene, None) , ( protein: NF-kappa B, None) , ( DNA: NF-AT binding sites, None) , ( DNA: responsive element, None) , ( DNA: NF-kappa B and the NF-AT binding sites, None) , ( cell line: Jurkat T cells, None) , ( protein: NF-AT, None) " }

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{ "id": "1903", "sentence": "We examined whether NF(P) , a nuclear factor specific for the P sequence , is related to NF-kappa B and NF-AT .", "label": " ( protein: NF(P), None) , ( protein: NF-kappa B, None) , ( protein: nuclear factor, None) , ( DNA: P sequence, None) , ( protein: NF-AT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF(P), None) , ( protein: NF-kappa B, None) , ( protein: nuclear factor, None) , ( DNA: P sequence, None) , ( protein: NF-AT, None) " }

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{ "id": "1904", "sentence": "NF-kappa B ( P65 or P65/P50 heterodimer ) bound to the P sequence in electrophoretic mobility shift assays ( EMSA ) and activated transcription through the P sequence when expression plasmids were cotransfected with P sequence -driven reporter plasmids in Jurkat T cells .", "label": " ( DNA: P sequence -driven reporter plasmids, None) , ( protein: P65/P50 heterodimer, None) , ( DNA: P sequence, None) , ( DNA: P sequence, None) , ( protein: P65, None) , ( DNA: expression plasmids, None) , ( protein: NF-kappa B, None) , ( DNA: P sequence, None) , ( cell line: Jurkat T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: P sequence -driven reporter plasmids, None) , ( protein: P65/P50 heterodimer, None) , ( DNA: P sequence, None) , ( DNA: P sequence, None) , ( protein: P65, None) , ( DNA: expression plasmids, None) , ( protein: NF-kappa B, None) , ( DNA: P sequence, None) , ( cell line: Jurkat T cells, None) " }

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{ "id": "1905", "sentence": "In EMSAs , NF(P) binding was inhibited by the unlabeled NF-AT binding site but not by the unlabeled AP1 binding site and purified NF-AT contained an activity that bound to the P sequence .", "label": " ( DNA: P sequence, None) , ( DNA: unlabeled NF-AT binding site, None) , ( protein: purified NF-AT, None) , ( protein: NF-AT, None) , ( DNA: unlabeled AP1 binding site, None) , ( protein: NF(P), None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: P sequence, None) , ( DNA: unlabeled NF-AT binding site, None) , ( protein: purified NF-AT, None) , ( protein: NF-AT, None) , ( DNA: unlabeled AP1 binding site, None) , ( protein: NF(P), None) " }

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{ "id": "1906", "sentence": "Both mobility shift and sequence specificity of NF-AT were similar to those of NF(P) and only a small amount of P65 was detected in NF(P) in crude nuclear extracts .", "label": " ( protein: NF(P), None) , ( protein: NF-AT, None) , ( protein: P65, None) , ( protein: NF(P), None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF(P), None) , ( protein: NF-AT, None) , ( protein: P65, None) , ( protein: NF(P), None) " }

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{ "id": "1907", "sentence": "These results indicate that the component(s) of NF-AT has the potential to reconstitute NF(P) whereas NF-kappa B alone cannot account for NF(P) in crude extracts .", "label": " ( protein: NF(P), None) , ( protein: NF-kappa B, None) , ( protein: NF-AT, None) , ( protein: NF(P), None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF(P), None) , ( protein: NF-kappa B, None) , ( protein: NF-AT, None) , ( protein: NF(P), None) " }

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{ "id": "1908", "sentence": "Unlike NF-AT , NF(P) does not contain AP1 as its DNA binding component .", "label": " ( protein: DNA binding component, None) , ( protein: NF(P), None) , ( protein: NF-AT, None) , ( protein: AP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNA binding component, None) , ( protein: NF(P), None) , ( protein: NF-AT, None) , ( protein: AP1, None) " }

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{ "id": "1909", "sentence": "Activation of early growth response 1 gene transcription and pp90rsk during induction of monocytic differentiation .", "label": " ( DNA: early growth response 1 gene, None) , ( protein: pp90rsk, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: early growth response 1 gene, None) , ( protein: pp90rsk, None) " }

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{ "id": "1910", "sentence": "The present work has studied mechanisms responsible for induction of early growth response 1 (EGR-1) gene expression during monocytic differentiation of U-937 myeloid leukemia cells .", "label": " ( cell line: U-937 myeloid leukemia cells, None) , ( DNA: early growth response 1 (EGR-1) gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: U-937 myeloid leukemia cells, None) , ( DNA: early growth response 1 (EGR-1) gene, None) " }

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{ "id": "1911", "sentence": "Differentiation of U-937 cells with 12-O-tetradecanoylphorbol-13-acetate ( TPA ), an activator of the serine/threonine protein kinase C , was associated with transcriptional activation of EGR-1 promoter-reporter constructs .", "label": " ( protein: serine/threonine protein kinase C, None) , ( cell line: U-937 cells, None) , ( protein: protein kinase C, None) , ( DNA: EGR-1 promoter-reporter constructs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: serine/threonine protein kinase C, None) , ( cell line: U-937 cells, None) , ( protein: protein kinase C, None) , ( DNA: EGR-1 promoter-reporter constructs, None) " }

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{ "id": "1912", "sentence": "The EGR-1 promoter contains six CC(A/T)6GG (CArG) motifs .", "label": " ( DNA: CC(A/T)6GG (CArG) motifs, None) , ( DNA: EGR-1 promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: CC(A/T)6GG (CArG) motifs, None) , ( DNA: EGR-1 promoter, None) " }

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{ "id": "1913", "sentence": "The two 5'-most distal CArG sequences conferred TPA inducibility.", "label": " ( DNA: 5#$%#-most distal CArG sequences, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: 5#$%#-most distal CArG sequences, None) " }

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{ "id": "1914", "sentence": "In contrast, there was little effect of TPA on EGR-1 transcription in a TPA -resistant U-937 cell variant , designated TUR .", "label": " ( cell line: TUR, None) , ( cell line: TPA -resistant U-937 cell variant, None) , ( DNA: EGR-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: TUR, None) , ( cell line: TPA -resistant U-937 cell variant, None) , ( DNA: EGR-1, None) " }

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{ "id": "1915", "sentence": "Treatment of both U-937 and TUR cells with okadaic acid , an inhibitor of serine/threonine protein phosphatases 1 and 2A , was associated with induction of monocytic differentiation and EGR-1 transcription through the 5'-most CArG element .", "label": " ( DNA: EGR-1, None) , ( cell line: U-937, None) , ( cell line: TUR cells, None) , ( DNA: 5#$%#-most CArG element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: EGR-1, None) , ( cell line: U-937, None) , ( cell line: TUR cells, None) , ( DNA: 5#$%#-most CArG element, None) " }

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{ "id": "1916", "sentence": "Since these findings supported the involvement of serine /threonine protein phosphorylation in the regulation of EGR-1 expression , we studied activation of the 40S ribosomal protein S6 serine /threonine kinases , pp70S6K and pp90rsk .", "label": " ( protein: pp70S6K, None) , ( protein: pp90rsk, None) , ( protein: 40S ribosomal protein S6 serine /threonine kinases, None) , ( DNA: EGR-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: pp70S6K, None) , ( protein: pp90rsk, None) , ( protein: 40S ribosomal protein S6 serine /threonine kinases, None) , ( DNA: EGR-1, None) " }

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{ "id": "1917", "sentence": "Although both kinases participate in regulating cell growth , there was no detectable activation of pp70S6K during TPA- or okadaic acid- induced monocytic differentiation .", "label": " ( protein: pp70S6K, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: pp70S6K, None) " }

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{ "id": "1918", "sentence": "Moreover, rapamycin, an inhibitor of pp70S6K activation , had no effect on induction of EGR-1 expression .", "label": " ( protein: pp70S6K, None) , ( DNA: EGR-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: pp70S6K, None) , ( DNA: EGR-1, None) " }

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{ "id": "1919", "sentence": "In contrast, analysis of pp90rsk activity by phosphorylation of a peptide derived from S6 protein demonstrated stimulation of this kinase in TPA-treated U-937 , and not TUR , cells .", "label": " ( protein: kinase, None) , ( protein: S6 protein, None) , ( protein: pp90rsk, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: kinase, None) , ( protein: S6 protein, None) , ( protein: pp90rsk, None) " }

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{ "id": "1920", "sentence": "Okadaic acid treatment of both cell types was associated with activation of pp90rsk .", "label": " ( protein: pp90rsk, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: pp90rsk, None) " }

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{ "id": "1921", "sentence": "Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals .", "label": " ( cell type: endothelial cells, None) , ( protein: vascular cell adhesion molecule-1, None) , ( cell type: monocyte, None) , ( protein: nuclear factor-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: endothelial cells, None) , ( protein: vascular cell adhesion molecule-1, None) , ( cell type: monocyte, None) , ( protein: nuclear factor-kappa B, None) " }

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{ "id": "1922", "sentence": "Cell adhesion to endothelial cells stimulated by tumor necrosis factor-alpha ( TNF ) is due to induction of surface receptors , such as vascular cell adhesion molecule-1 ( VCAM-1 ).", "label": " ( protein: VCAM-1, None) , ( cell type: endothelial cells, None) , ( protein: vascular cell adhesion molecule-1, None) , ( protein: stimulated by tumor necrosis factor-alpha, None) , ( protein: surface receptors, None) , ( protein: TNF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: VCAM-1, None) , ( cell type: endothelial cells, None) , ( protein: vascular cell adhesion molecule-1, None) , ( protein: stimulated by tumor necrosis factor-alpha, None) , ( protein: surface receptors, None) , ( protein: TNF, None) " }

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{ "id": "1923", "sentence": "The antioxidant pyrrolidine dithiocarbamate ( PDTC ) specifically inhibits activation of nuclear factor-kappa B ( NF-kappa B ).", "label": " ( protein: NF-kappa B, None) , ( protein: nuclear factor-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: nuclear factor-kappa B, None) " }

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{ "id": "1924", "sentence": "Since kappa B motifs are present in VCAM-1 and intercellular adhesion molecule-1 ( ICAM-1 ) promoters , we used PDTC to study the regulatory mechanisms of VCAM-1 and ICAM-1 induction and subsequent monocyte adhesion in TNF-treated human umbilical vein endothelial cells ( HUVECs ).", "label": " ( protein: VCAM-1, None) , ( protein: VCAM-1, None) , ( DNA: VCAM-1 and intercellular adhesion molecule-1 ( ICAM-1 ) promoters, None) , ( cell line: HUVECs, None) , ( DNA: kappa B motifs, None) , ( cell line: TNF-treated human umbilical vein endothelial cells, None) , ( protein: intercellular adhesion molecule-1, None) , ( DNA: intercellular adhesion molecule-1 ( ICAM-1 ) promoters, None) , ( protein: ICAM-1, None) , ( cell type: endothelial cells, None) , ( protein: ICAM-1, None) , ( cell type: monocyte, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: VCAM-1, None) , ( protein: VCAM-1, None) , ( DNA: VCAM-1 and intercellular adhesion molecule-1 ( ICAM-1 ) promoters, None) , ( cell line: HUVECs, None) , ( DNA: kappa B motifs, None) , ( cell line: TNF-treated human umbilical vein endothelial cells, None) , ( protein: intercellular adhesion molecule-1, None) , ( DNA: intercellular adhesion molecule-1 ( ICAM-1 ) promoters, None) , ( protein: ICAM-1, None) , ( cell type: endothelial cells, None) , ( protein: ICAM-1, None) , ( cell type: monocyte, None) " }

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{ "id": "1925", "sentence": "PDTC or N-acetylcysteine dose dependently reduced TNF-induced VCAM-1 but not ICAM-1 surface protein (also in human umbilical arterial endothelial cells ) and mRNA expression (by 70% at 100 mumol/L PDTC ) in HUVECs as assessed by flow cytometry and polymerase chain reaction .", "label": " ( cell type: human umbilical arterial endothelial cells, None) , ( cell line: HUVECs, None) , ( protein: VCAM-1, None) , ( cell type: endothelial cells, None) , ( protein: ICAM-1, None) , ( protein: TNF-induced VCAM-1, None) , ( protein: ICAM-1 surface protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human umbilical arterial endothelial cells, None) , ( cell line: HUVECs, None) , ( protein: VCAM-1, None) , ( cell type: endothelial cells, None) , ( protein: ICAM-1, None) , ( protein: TNF-induced VCAM-1, None) , ( protein: ICAM-1 surface protein, None) " }

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{ "id": "1926", "sentence": "Gel-shift analysis in HUVECs demonstrated that PDTC prevented NF-kappa B mobilization by TNF , suggesting that only VCAM-1 induction was controlled by NF-kappa B .", "label": " ( protein: NF-kappa B, None) , ( protein: TNF, None) , ( cell line: HUVECs, None) , ( protein: NF-kappa B, None) , ( protein: VCAM-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: TNF, None) , ( cell line: HUVECs, None) , ( protein: NF-kappa B, None) , ( protein: VCAM-1, None) " }

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{ "id": "1927", "sentence": "Since HUVECs released superoxide anions in response to TNF, and H2O2 induces VCAM-1 , PDTC may act as a radical scavenger .", "label": " ( protein: VCAM-1, None) , ( cell line: HUVECs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: VCAM-1, None) , ( cell line: HUVECs, None) " }

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{ "id": "1928", "sentence": "Although ICAM-1 induction was unaffected, inhibitors of NADPH oxidase ( apocynin ) or cytochrome P-450 ( SKF525a ) suppressed VCAM-1 induction by TNF, revealing that several radical-generating systems are involved in its regulation.", "label": " ( protein: NADPH oxidase, None) , ( protein: cytochrome P-450, None) , ( protein: ICAM-1, None) , ( protein: VCAM-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NADPH oxidase, None) , ( protein: cytochrome P-450, None) , ( protein: ICAM-1, None) , ( protein: VCAM-1, None) " }

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{ "id": "1929", "sentence": "PDTC , apocynin , or SKF525a decreased adhesion of monocytic U937 cells to TNF-treated HUVECs (by 75% at 100 mumol/L PDTC ).", "label": " ( cell line: TNF-treated HUVECs, None) , ( cell line: HUVECs, None) , ( cell line: monocytic U937 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: TNF-treated HUVECs, None) , ( cell line: HUVECs, None) , ( cell line: monocytic U937 cells, None) " }

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{ "id": "1930", "sentence": "Inhibition by anti- VCAM-1 monoclonal antibody 1G11 indicated that U937 adhesion was VCAM-1 dependent and suppression by antioxidants was due to reduced VCAM-1 induction .", "label": " ( protein: VCAM-1, None) , ( protein: VCAM-1, None) , ( protein: VCAM-1, None) , ( protein: 1G11, None) , ( protein: anti- VCAM-1 monoclonal antibody, None) , ( cell line: U937, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: VCAM-1, None) , ( protein: VCAM-1, None) , ( protein: VCAM-1, None) , ( protein: 1G11, None) , ( protein: anti- VCAM-1 monoclonal antibody, None) , ( cell line: U937, None) " }

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{ "id": "1931", "sentence": "(ABSTRACT TRUNCATED AT 250 WORDS)", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1932", "sentence": "Displacement of an E-box-binding repressor by basic helix-loop-helix proteins : implications for B-cell specificity of the immunoglobulin heavy-chain enhancer .", "label": " ( DNA: immunoglobulin heavy-chain enhancer, None) , ( protein: basic helix-loop-helix proteins, None) , ( protein: E-box-binding repressor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: immunoglobulin heavy-chain enhancer, None) , ( protein: basic helix-loop-helix proteins, None) , ( protein: E-box-binding repressor, None) " }

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{ "id": "1933", "sentence": "The activity of the immunoglobulin heavy-chain (IgH) enhancer is restricted to B cells , although it binds both B-cell-restricted and ubiquitous transcription factors .", "label": " ( cell type: B cells, None) , ( DNA: immunoglobulin heavy-chain (IgH) enhancer, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B cells, None) , ( DNA: immunoglobulin heavy-chain (IgH) enhancer, None) " }

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{ "id": "1934", "sentence": "Activation of the enhancer in non- B cells upon overexpression of the basic helix-loop-helix (bHLH) protein E2A appears to be mediated not only by the binding of E2A to its cognate E box but also by the resulting displacement of a repressor from that same site.", "label": " ( cell type: non- B cells, None) , ( protein: repressor, None) , ( protein: E2A, None) , ( protein: E2A, None) , ( cell type: B cells, None) , ( DNA: E box, None) , ( protein: basic helix-loop-helix (bHLH) protein, None) , ( DNA: enhancer, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: non- B cells, None) , ( protein: repressor, None) , ( protein: E2A, None) , ( protein: E2A, None) , ( cell type: B cells, None) , ( DNA: E box, None) , ( protein: basic helix-loop-helix (bHLH) protein, None) , ( DNA: enhancer, None) " }

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{ "id": "1935", "sentence": "We have identified a \"two-handed\" zinc finger protein , denoted ZEB , the DNA-binding specificity of which mimics that of the cellular repressor .", "label": " ( protein: \"two-handed\" zinc finger protein, None) , ( protein: cellular repressor, None) , ( protein: ZEB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: \"two-handed\" zinc finger protein, None) , ( protein: cellular repressor, None) , ( protein: ZEB, None) " }

[]

{ "id": "1936", "sentence": "By employing a derivative E box that binds ZEB but not E2A , we have shown that the repressor is active in B cells and the IgH enhancer is silenced in the absence of binding competition by bHLH proteins .", "label": " ( DNA: E box, None) , ( protein: ZEB, None) , ( cell type: B cells, None) , ( protein: repressor, None) , ( protein: E2A, None) , ( DNA: IgH enhancer, None) , ( protein: bHLH proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: E box, None) , ( protein: ZEB, None) , ( cell type: B cells, None) , ( protein: repressor, None) , ( protein: E2A, None) , ( DNA: IgH enhancer, None) , ( protein: bHLH proteins, None) " }

[]

{ "id": "1937", "sentence": "Hence, we propose that a necessary prerequisite of enhancer activity is the B-cell-specific displacement of a ZEB -like repressor by bHLH proteins .", "label": " ( protein: bHLH proteins, None) , ( protein: ZEB -like repressor, None) , ( protein: ZEB, None) , ( DNA: enhancer, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: bHLH proteins, None) , ( protein: ZEB -like repressor, None) , ( protein: ZEB, None) , ( DNA: enhancer, None) " }

[]

{ "id": "1938", "sentence": "Inhibition of NF-kappa B by sodium salicylate and aspirin [see comments]", "label": " ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) " }

[]

{ "id": "1939", "sentence": "The transcription factor nuclear factor-kappa B ( NF-kappa B ) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 ( IL-1 ), IL-6 , and adhesion molecules .", "label": " ( protein: nuclear factor-kappa B, None) , ( protein: transcription factor, None) , ( protein: IL-1, None) , ( protein: interleukin-1, None) , ( protein: NF-kappa B, None) , ( protein: adhesion molecules, None) , ( protein: IL-6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor-kappa B, None) , ( protein: transcription factor, None) , ( protein: IL-1, None) , ( protein: interleukin-1, None) , ( protein: NF-kappa B, None) , ( protein: adhesion molecules, None) , ( protein: IL-6, None) " }

[]

{ "id": "1940", "sentence": "The anti-inflammatory drugs sodium salicylate and aspirin inhibited the activation of NF-kappa B , which further explains the mechanism of action of these drugs.", "label": " ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) " }

[]

{ "id": "1941", "sentence": "This inhibition prevented the degradation of the NF-kappa B inhibitor , I kappa B , and therefore NF-kappa B was retained in the cytosol .", "label": " ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: I kappa B, None) , ( protein: NF-kappa B inhibitor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: I kappa B, None) , ( protein: NF-kappa B inhibitor, None) " }

[]

{ "id": "1942", "sentence": "Sodium salicylate and aspirin also inhibited NF-kappa B -dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat ( LTR ) in transfected T cells .", "label": " ( protein: NF-kappa B, None) , ( DNA: human immunodeficiency virus (HIV) long terminal repeat, None) , ( DNA: LTR, None) , ( DNA: Ig kappa enhancer, None) , ( cell line: transfected T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( DNA: human immunodeficiency virus (HIV) long terminal repeat, None) , ( DNA: LTR, None) , ( DNA: Ig kappa enhancer, None) , ( cell line: transfected T cells, None) " }

[]

{ "id": "1943", "sentence": "Effects of the antisense myb expression on hemin- and erythropoietin- induced erythroid differentiation of K562 cells .", "label": " ( cell line: K562 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: K562 cells, None) " }

[]

{ "id": "1944", "sentence": "In order to elucidate the role of c-myb gene in erythroid differentiation of K562 cell induced by hemin ( Hm ) and erythropoietin ( Epo ), we constructed recombinant plasmid that could produce antisense myb RNA after induction with dexamethasone .", "label": " ( protein: erythropoietin, None) , ( DNA: recombinant plasmid, None) , ( protein: Hm, None) , ( protein: Epo, None) , ( RNA: antisense myb RNA, None) , ( DNA: c-myb gene, None) , ( protein: hemin, None) , ( cell line: K562 cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: erythropoietin, None) , ( DNA: recombinant plasmid, None) , ( protein: Hm, None) , ( protein: Epo, None) , ( RNA: antisense myb RNA, None) , ( DNA: c-myb gene, None) , ( protein: hemin, None) , ( cell line: K562 cell, None) " }

[]

{ "id": "1945", "sentence": "During treatment with Hm , K562 cells constitutively expressed c-myb mRNA , and 50% of them began to synthesize hemoglobin ( Hb ).", "label": " ( protein: hemoglobin, None) , ( cell line: K562 cells, None) , ( protein: Hm, None) , ( protein: Hb, None) , ( RNA: c-myb mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hemoglobin, None) , ( cell line: K562 cells, None) , ( protein: Hm, None) , ( protein: Hb, None) , ( RNA: c-myb mRNA, None) " }

[]

{ "id": "1946", "sentence": "Expression of antisense myb RNA reduced the amount of c-myb mRNA , and the percentage of Hb -synthesizing cells was decreased to 20%.", "label": " ( RNA: antisense myb RNA, None) , ( cell line: Hb -synthesizing cells, None) , ( RNA: c-myb mRNA, None) , ( protein: Hb, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: antisense myb RNA, None) , ( cell line: Hb -synthesizing cells, None) , ( RNA: c-myb mRNA, None) , ( protein: Hb, None) " }

[]

{ "id": "1947", "sentence": "In the presence of Epo , c-myb mRNA declined and 20% of K562 cells synthesized Hb regardless of antisense myb RNA expression.", "label": " ( protein: Epo, None) , ( protein: Hb, None) , ( RNA: c-myb mRNA, None) , ( cell line: K562 cells, None) , ( RNA: antisense myb RNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Epo, None) , ( protein: Hb, None) , ( RNA: c-myb mRNA, None) , ( cell line: K562 cells, None) , ( RNA: antisense myb RNA, None) " }

[]

{ "id": "1948", "sentence": "It is suggested that constitutive expression of c-myb mRNA is necessary for Hm -induced differentiation , and that a decrease in the amount of c-myb mRNA induced by antisense myb RNA expression suppresses Hm -induced differentiation .", "label": " ( RNA: c-myb mRNA, None) , ( RNA: c-myb mRNA, None) , ( RNA: antisense myb RNA, None) , ( protein: Hm, None) , ( protein: Hm, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: c-myb mRNA, None) , ( RNA: c-myb mRNA, None) , ( RNA: antisense myb RNA, None) , ( protein: Hm, None) , ( protein: Hm, None) " }

[]

{ "id": "1949", "sentence": "The amount of c-myb mRNA in K562 cells was reduced during the differentiation induced by Epo .", "label": " ( protein: Epo, None) , ( cell line: K562 cells, None) , ( RNA: c-myb mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Epo, None) , ( cell line: K562 cells, None) , ( RNA: c-myb mRNA, None) " }

[]

{ "id": "1950", "sentence": "Expression of GATA-1 mRNA was almost constant during Hm -induced differentiation , but increased during Epo treatment .", "label": " ( RNA: GATA-1 mRNA, None) , ( protein: Hm, None) , ( protein: Epo, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: GATA-1 mRNA, None) , ( protein: Hm, None) , ( protein: Epo, None) " }

[]

{ "id": "1951", "sentence": "It is supposed that the mechanism of Hm -induced differentiation is distinguished from that of Epo -induced differentiation in K562 cells .", "label": " ( protein: Hm, None) , ( cell line: K562 cells, None) , ( protein: Epo, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Hm, None) , ( cell line: K562 cells, None) , ( protein: Epo, None) " }

[]

{ "id": "1952", "sentence": "Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1953", "sentence": "We investigated whether non-abortive maternal infections would compromise fetal brain development and alter hypothalamic-pituitary-adrenocortical (HPA) axis functioning when adult.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1954", "sentence": "To study putative teratogenic effects of a T cell-mediated immune response versus an endotoxic challenge , 10-d-pregnant rats received a single intraperitoneal injection of 5 x 10(8) human red blood cells ( HRBC ) or gram-negative bacterial endotoxin ( Escherichia coli LPS : 30 micrograms/kg).", "label": " ( cell type: HRBC, None) , ( cell type: human red blood cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: HRBC, None) , ( cell type: human red blood cells, None) " }

[]

{ "id": "1955", "sentence": "The adult male progeny (3 mo old) of both experimental groups showed increased basal plasma corticosterone levels .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1956", "sentence": "In addition, after novelty stress the HRBC group, but not the LPS group , showed increased ACTH and corticosterone levels .", "label": " ( cell type: HRBC, None) , ( cell line: LPS group, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: HRBC, None) , ( cell line: LPS group, None) " }

[]

{ "id": "1957", "sentence": "Both groups showed substantial decreases in mineralocorticoid (MR) and glucocorticoid receptor (GR) levels in the hippocampus , a limbic brain structure critical for HPA axis regulation , whereas GR concentrations in the hypothalamus were unchanged and in anterior pituitary were slightly increased.", "label": " ( protein: GR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GR, None) " }

[]

{ "id": "1958", "sentence": "HRBC and LPS indeed stimulated the maternal immune system as revealed by specific anti- HRBC antibody production and enhanced IL-1 beta mRNA expression in splenocytes , respectively.", "label": " ( cell type: splenocytes, None) , ( cell type: HRBC, None) , ( cell type: HRBC, None) , ( protein: anti- HRBC antibody, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: splenocytes, None) , ( cell type: HRBC, None) , ( cell type: HRBC, None) , ( protein: anti- HRBC antibody, None) " }

[]

{ "id": "1959", "sentence": "This study demonstrates that a T cell-mediated immune response as well as an endotoxic challenge during pregnancy can induce anomalies in HPA axis function in adulthood.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1960", "sentence": "Clinically, it may be postulated that disturbed fetal brain development due to prenatal immune challenge increases the vulnerability to develop mental illness involving inadequate responses to stress .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1961", "sentence": "A low NM23.H1 gene expression identifying high malignancy human melanomas .", "label": " ( DNA: NM23.H1 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: NM23.H1 gene, None) " }

[]

{ "id": "1962", "sentence": "The NM23 gene has been proposed as a metastasis-suppressor gene , and its use has been suggested as prognostic factor .", "label": " ( DNA: NM23 gene, None) , ( DNA: metastasis-suppressor gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: NM23 gene, None) , ( DNA: metastasis-suppressor gene, None) " }

[]

{ "id": "1963", "sentence": "NM23 was identified in a system of murine melanoma cell lines , in which an inverse relationship was found between NM23 expression and metastatic ability .", "label": " ( protein: NM23, None) , ( protein: NM23, None) , ( cell line: murine melanoma cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NM23, None) , ( protein: NM23, None) , ( cell line: murine melanoma cell lines, None) " }

[]

{ "id": "1964", "sentence": "In a human malignant melanoma study NM23 expression was found to be significantly lower in metastases that developed less than 24 months after diagnosis of the primary tumours .", "label": " ( protein: NM23, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NM23, None) " }

[]

{ "id": "1965", "sentence": "The present paper studies the expression of the NM23 .H1 gene in cell lines which derive from primary or metastatic human malignant melanomas in relation to staging, infiltration degree, lymphocytic infiltration , cell morphology , cell pigmentation , karyotype , and disease-free survival .", "label": " ( cell line: cell lines, None) , ( protein: NM23, None) , ( DNA: NM23 .H1 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: cell lines, None) , ( protein: NM23, None) , ( DNA: NM23 .H1 gene, None) " }

[]

{ "id": "1966", "sentence": "The level of mRNA expression of the NM23 gene is significantly lower in cell lines that derive from more infiltrating primary melanomas than in cell lines obtained from less infiltrating tumours .", "label": " ( cell line: cell lines, None) , ( DNA: NM23 gene, None) , ( protein: NM23, None) , ( cell line: cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: cell lines, None) , ( DNA: NM23 gene, None) , ( protein: NM23, None) , ( cell line: cell lines, None) " }

[]

{ "id": "1967", "sentence": "Moreover, cell lines derived from tumours of patients with a disease-free survival of more than 24 months (24-58 months) express the NM23 gene at higher levels than cell lines obtained from melanomas of patients with a disease-free survival of less than 24 months (6-15 months).", "label": " ( protein: NM23, None) , ( DNA: NM23 gene, None) , ( cell line: cell lines, None) , ( cell line: cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NM23, None) , ( DNA: NM23 gene, None) , ( cell line: cell lines, None) , ( cell line: cell lines, None) " }

[]

{ "id": "1968", "sentence": "Activation of a novel serine /threonine kinase that phosphorylates c-Fos upon stimulation of T and B lymphocytes via antigen and cytokine receptors .", "label": " ( protein: cytokine receptors, None) , ( protein: serine /threonine kinase, None) , ( protein: c-Fos, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine receptors, None) , ( protein: serine /threonine kinase, None) , ( protein: c-Fos, None) " }

[]

{ "id": "1969", "sentence": "Ligation of Ag receptors in T and B lymphocytes initiates signal transduction cascades which alter the expression of genes that regulate cellular proliferation and differentiation .", "label": " ( protein: Ag receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Ag receptors, None) " }

[]

{ "id": "1970", "sentence": "The transmission of signals from the membrane to the nucleus is mediated principally through the action of protein tyrosine and serine/threonine kinases .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1971", "sentence": "We have identified and characterized a novel serine /threonine kinase that phosphorylated the proto-oncogene product , c-Fos , and is termed Fos kinase .", "label": " ( protein: serine /threonine kinase, None) , ( protein: Fos kinase, None) , ( protein: c-Fos, None) , ( protein: proto-oncogene product, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: serine /threonine kinase, None) , ( protein: Fos kinase, None) , ( protein: c-Fos, None) , ( protein: proto-oncogene product, None) " }

[]

{ "id": "1972", "sentence": "Fos kinase was rapidly activated after ligation of the CD3 and CD2 receptors in Jurkat and normal human T lymphocytes and in response to IL-6 and anti-IgM in the human B cell lines AF10 and Ramos , respectively.", "label": " ( protein: anti-IgM, None) , ( protein: IL-6, None) , ( cell type: normal human T lymphocytes, None) , ( cell line: cell lines, None) , ( protein: Fos kinase, None) , ( cell line: Ramos, None) , ( cell line: AF10, None) , ( cell line: human B cell lines, None) , ( cell line: Jurkat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti-IgM, None) , ( protein: IL-6, None) , ( cell type: normal human T lymphocytes, None) , ( cell line: cell lines, None) , ( protein: Fos kinase, None) , ( cell line: Ramos, None) , ( cell line: AF10, None) , ( cell line: human B cell lines, None) , ( cell line: Jurkat, None) " }

[]

{ "id": "1973", "sentence": "The phorbol ester , PMA , was also a potent inducer of Fos kinase activity in all of the above populations, suggesting that PKC plays a role in the regulation of this enzyme .", "label": " ( protein: Fos kinase, None) , ( protein: enzyme, None) , ( protein: PKC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Fos kinase, None) , ( protein: enzyme, None) , ( protein: PKC, None) " }

[]

{ "id": "1974", "sentence": "Fos kinase phosphorylates c-Fos at a site near the C-terminus , as well as a peptide derived from this region ( residues 359-370 , RKGSSSNEPSSD ), and Fos peptide competitively inhibited c-Fos phosphorylation.", "label": " ( protein: c-Fos, None) , ( protein: residues 359-370, None) , ( protein: c-Fos, None) , ( protein: Fos kinase, None) , ( protein: RKGSSSNEPSSD, None) , ( protein: C-terminus, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c-Fos, None) , ( protein: residues 359-370, None) , ( protein: c-Fos, None) , ( protein: Fos kinase, None) , ( protein: RKGSSSNEPSSD, None) , ( protein: C-terminus, None) " }

[]

{ "id": "1975", "sentence": "Fos kinase was shown to be distinct from other identified serine /threonine kinases , including protein kinase A , protein kinase C , casein kinase II , MAP kinases , p70S6K and p90RSK .", "label": " ( protein: p90RSK, None) , ( protein: protein kinase C, None) , ( protein: MAP kinases, None) , ( protein: serine /threonine kinases, None) , ( protein: casein kinase II, None) , ( protein: p70S6K, None) , ( protein: protein kinase A, None) , ( protein: Fos kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p90RSK, None) , ( protein: protein kinase C, None) , ( protein: MAP kinases, None) , ( protein: serine /threonine kinases, None) , ( protein: casein kinase II, None) , ( protein: p70S6K, None) , ( protein: protein kinase A, None) , ( protein: Fos kinase, None) " }

[]

{ "id": "1976", "sentence": "Fos kinase was purified by anion exchange chromatography and exhibited an apparent M(r) = 65,000 and isoelectric point = 6.1.", "label": " ( protein: Fos kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Fos kinase, None) " }

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{ "id": "1977", "sentence": "Fos kinase may play a role in transcriptional regulation through its capacity to phosphorylate c-Fos at a site required for expression of the transcriptional transrepressive activity of this molecule.", "label": " ( protein: c-Fos, None) , ( protein: Fos kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c-Fos, None) , ( protein: Fos kinase, None) " }

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{ "id": "1978", "sentence": "Moreover, its rapid activation suggests it may have a wider role within signal transduction cascades in lymphocytes .", "label": " ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphocytes, None) " }

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{ "id": "1979", "sentence": "Antigenic specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions .", "label": " ( cell line: human CD4+ T-cell clones, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: human CD4+ T-cell clones, None) " }

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{ "id": "1980", "sentence": "Lesions resulting from recurrent genital herpes simplex virus ( HSV ) infection are characterized by infiltration of CD4+ lymphocytes .", "label": " ( cell type: CD4+ lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: CD4+ lymphocytes, None) " }

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{ "id": "1981", "sentence": "We have investigated the antigenic specificity of 47 HSV-specific CD4+ T-cell clones recovered from the HSV-2 buttock and thigh lesions of five patients .", "label": " ( cell line: HSV-specific CD4+ T-cell clones, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HSV-specific CD4+ T-cell clones, None) " }

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{ "id": "1982", "sentence": "Clones with proliferative responses to recombinant truncated glycoprotein B ( gB ) or gD of HSV-2 or purified natural gC of HSV-2 comprised a minority of the total number of HSV-specific clones isolated from lesions .", "label": " ( cell line: HSV-specific clones, None) , ( protein: gB, None) , ( protein: recombinant truncated glycoprotein B, None) , ( protein: gD, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HSV-specific clones, None) , ( protein: gB, None) , ( protein: recombinant truncated glycoprotein B, None) , ( protein: gD, None) " }

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{ "id": "1983", "sentence": "The gC2- and gD2- specific CD4+ clones had cytotoxic activity .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1984", "sentence": "The approximate locations of the HSV-2 genes encoding HSV-2 type-specific CD4+ antigens have been determined by using HSV-1 x HSV-2 intertypic recombinant virus and include the approximate map regions 0.30 to 0.46 , 0.59 to 0.67 , 0.67 to 0.73 , and 0.82 to 1.0 units .", "label": " ( protein: CD4+ antigens, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD4+ antigens, None) " }

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{ "id": "1985", "sentence": "The antigenic specificity of an HLA DQ2-restricted, HSV-2 type-specific T-cell clone was mapped to amino acids 425 to 444 of VP16 of HSV-2 by sequential use of an intertypic recombinant virus containing VP16 of HSV-2 in an HSV-1 background , recombinant VP16 fusion proteins , and synthetic peptides .", "label": " ( protein: VP16, None) , ( protein: VP16, None) , ( protein: recombinant VP16 fusion proteins, None) , ( cell line: HLA DQ2-restricted, HSV-2 type-specific T-cell clone, None) , ( protein: VP16, None) , ( protein: amino acids 425 to 444, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: VP16, None) , ( protein: VP16, None) , ( protein: recombinant VP16 fusion proteins, None) , ( cell line: HLA DQ2-restricted, HSV-2 type-specific T-cell clone, None) , ( protein: VP16, None) , ( protein: amino acids 425 to 444, None) " }

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{ "id": "1986", "sentence": "Each of the remaining four patients also yielded at least one type-specific T-cell clone reactive with an HSV-2 epitope mapping to approximately 0.67 to 0.73 map units .", "label": " ( cell line: type-specific T-cell clone, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: type-specific T-cell clone, None) " }

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{ "id": "1987", "sentence": "The antigenic specificities of lesion-derived CD4+ T-cell clones are quite diverse and include at least 10 epitopes.", "label": " ( cell line: lesion-derived CD4+ T-cell clones, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: lesion-derived CD4+ T-cell clones, None) " }

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{ "id": "1988", "sentence": "Human T-cell clones reactive with gC and VP16 are reported here for the first time.", "label": " ( protein: VP16, None) , ( protein: gC, None) , ( cell line: Human T-cell clones, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: VP16, None) , ( protein: gC, None) , ( cell line: Human T-cell clones, None) " }

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{ "id": "1989", "sentence": "Marked basophilia in acute promyelocytic leukaemia treated with all-trans retinoic acid : molecular analysis of the cell origin of the basophils .", "label": " ( cell type: basophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: basophils, None) " }

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{ "id": "1990", "sentence": "We report a patient with acute promyelocytic leukaemia who developed marked basophilia during all-trans retinoic acid treatment .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1991", "sentence": "We studied genomic DNA and RNA extracted from the patient's peripheral leucocytes in order to determine the origin of the basophils .", "label": " ( cell type: basophils, None) , ( DNA: genomic DNA, None) , ( RNA: RNA, None) , ( cell type: peripheral leucocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: basophils, None) , ( DNA: genomic DNA, None) , ( RNA: RNA, None) , ( cell type: peripheral leucocytes, None) " }

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{ "id": "1992", "sentence": "The RAR alpha rearranged band in the Southern blot analysis and a chimaeric product of PML-RAR alpha by polymerase chain reaction were strongly visible before ATRA treatment , but at the time of maximal basophilia both of them were markedly diminished.", "label": " ( protein: PML-RAR alpha, None) , ( protein: chimaeric product, None) , ( protein: RAR alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PML-RAR alpha, None) , ( protein: chimaeric product, None) , ( protein: RAR alpha, None) " }

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{ "id": "1993", "sentence": "These findings suggest that the basophils which appeared during the ATRA treatment are reactive in nature rather than a leukaemic clone .", "label": " ( cell line: leukaemic clone, None) , ( cell type: basophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: leukaemic clone, None) , ( cell type: basophils, None) " }

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{ "id": "1994", "sentence": "Activation of the interleukin 6 gene by Mycobacterium tuberculosis or lipopolysaccharide is mediated by nuclear factors NF-IL6 and NF-kappa B [published erratum appears in Proc Natl Acad Sci U S A 1995 Apr 11;92(8):3632]", "label": " ( protein: NF-kappa B, None) , ( DNA: interleukin 6 gene, None) , ( protein: nuclear factors NF-IL6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( DNA: interleukin 6 gene, None) , ( protein: nuclear factors NF-IL6, None) " }

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{ "id": "1995", "sentence": "The host response to Mycobacterium tuberculosis includes granuloma formation at sites of infection and systemic symptoms .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1996", "sentence": "Cytokines have been identified by immunohistochemistry in granulomas in animal models of bacillus Calmette-Guerin (BCG) infection and are released by mononuclear phagocytes upon stimulation by mycobacterial proteins.", "label": " ( protein: Cytokines, None) , ( cell type: mononuclear phagocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Cytokines, None) , ( cell type: mononuclear phagocytes, None) " }

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{ "id": "1997", "sentence": "In this regard, the cytokine interleukin 6 ( IL-6 ) may play a role in the clinical manifestations and pathological events of tuberculosis infection .", "label": " ( protein: tuberculosis infection, None) , ( protein: interleukin 6, None) , ( protein: IL-6, None) , ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tuberculosis infection, None) , ( protein: interleukin 6, None) , ( protein: IL-6, None) , ( protein: cytokine, None) " }

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{ "id": "1998", "sentence": "We have demonstrated that lipoarabinomannan ( LAM ) from the mycobacterial cell wall, which was virtually devoid of lipopolysaccharide ( LPS ), stimulated mononuclear phagocytes to release IL-6 in a dose-response manner .", "label": " ( protein: LAM, None) , ( protein: IL-6, None) , ( cell type: mononuclear phagocytes, None) , ( protein: lipoarabinomannan, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LAM, None) , ( protein: IL-6, None) , ( cell type: mononuclear phagocytes, None) , ( protein: lipoarabinomannan, None) " }

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{ "id": "1999", "sentence": "LAM and LPS were potent inducers of IL-6 gene expression in peripheral blood monocytes .", "label": " ( cell type: peripheral blood monocytes, None) , ( protein: LAM, None) , ( DNA: IL-6 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral blood monocytes, None) , ( protein: LAM, None) , ( DNA: IL-6 gene, None) " }