Datasets:

huy-nh-2000

/

instructUIE

like 0

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{ "id": "1700", "sentence": "By using transient transfection assays , we found that cross-linking CD40 supports NF-kappa B -dependent gene expression .", "label": " ( protein: NF-kappa B, None) , ( protein: CD40, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: CD40, None) " }

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{ "id": "1701", "sentence": "Our results define the NF-kappa B system as an intermediate event in CD40 signaling and suggest that the CD40 pathway can influence the expression of B cell-associated genes with NF-kappa B consensus sites .", "label": " ( protein: CD40, None) , ( protein: CD40, None) , ( DNA: NF-kappa B consensus sites, None) , ( protein: NF-kappa B, None) , ( DNA: B cell-associated genes, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD40, None) , ( protein: CD40, None) , ( DNA: NF-kappa B consensus sites, None) , ( protein: NF-kappa B, None) , ( DNA: B cell-associated genes, None) , ( protein: NF-kappa B, None) " }

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{ "id": "1702", "sentence": "Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/ p65 heterodimers .", "label": " ( protein: p65, None) , ( protein: c-Rel/ p65 heterodimers, None) , ( cell type: human monocytic cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p65, None) , ( protein: c-Rel/ p65 heterodimers, None) , ( cell type: human monocytic cells, None) " }

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{ "id": "1703", "sentence": "Tissue factor ( TF ) is expressed rapidly by human monocytes exposed to bacterial endotoxin ( lipopolysaccharide , or LPS ).", "label": " ( protein: Tissue factor, None) , ( cell type: human monocytes, None) , ( protein: bacterial endotoxin, None) , ( protein: TF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tissue factor, None) , ( cell type: human monocytes, None) , ( protein: bacterial endotoxin, None) , ( protein: TF, None) " }

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{ "id": "1704", "sentence": "Transcriptional regulation is mediated by binding of c-Rel /p65 heterodimers to a kappa B-like site in the TF promoter .", "label": " ( protein: TF, None) , ( protein: /p65, None) , ( protein: c-Rel, None) , ( DNA: kappa B-like site, None) , ( DNA: TF promoter, None) , ( protein: c-Rel /p65 heterodimers, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TF, None) , ( protein: /p65, None) , ( protein: c-Rel, None) , ( DNA: kappa B-like site, None) , ( DNA: TF promoter, None) , ( protein: c-Rel /p65 heterodimers, None) " }

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{ "id": "1705", "sentence": "Nuclear translocation of cytosolic c-Rel/ p65 heterodimers and other members of the NF-kappa B /Rel family requires dissociation and proteolytic degradation of the inhibitor protein , I kappa B alpha .", "label": " ( protein: inhibitor protein, None) , ( protein: cytosolic c-Rel/ p65 heterodimers, None) , ( protein: NF-kappa B, None) , ( protein: p65, None) , ( protein: NF-kappa B /Rel family, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: inhibitor protein, None) , ( protein: cytosolic c-Rel/ p65 heterodimers, None) , ( protein: NF-kappa B, None) , ( protein: p65, None) , ( protein: NF-kappa B /Rel family, None) , ( protein: I kappa B alpha, None) " }

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{ "id": "1706", "sentence": "The protease inhibitors N alpha-tosylphenylalanyl chloromethyl ketone ( TPCK ) and N alpha-tosyl-L-lysine chloromethyl ketone ( TLCK ) block activation of NF-kappa B /Rel proteins by preventing degradation of I kappa B alpha .", "label": " ( protein: NF-kappa B /Rel proteins, None) , ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B /Rel proteins, None) , ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) " }

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{ "id": "1707", "sentence": "To determine if TPCK and TLCK inhibited LPS induction of TF expression , freshly isolated human monocytes and monocytic THP-1 cells were pretreated with these inhibitors for 30 min before LPS stimulation .", "label": " ( protein: TF, None) , ( cell line: monocytic THP-1 cells, None) , ( cell type: human monocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TF, None) , ( cell line: monocytic THP-1 cells, None) , ( cell type: human monocytes, None) " }

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{ "id": "1708", "sentence": "Both TPCK and TLCK inhibited LPS induction of TF protein , TF mRNA and TF promoter activity in a dose-dependent manner .", "label": " ( protein: TF, None) , ( RNA: TF mRNA, None) , ( protein: TF protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TF, None) , ( RNA: TF mRNA, None) , ( protein: TF protein, None) " }

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{ "id": "1709", "sentence": "These inhibitors specifically prevented degradation of I kappa B alpha and nuclear translocation of c-Rel /p65 heterodimers .", "label": " ( protein: /p65, None) , ( protein: c-Rel, None) , ( protein: c-Rel /p65 heterodimers, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: /p65, None) , ( protein: c-Rel, None) , ( protein: c-Rel /p65 heterodimers, None) , ( protein: I kappa B alpha, None) " }

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{ "id": "1710", "sentence": "In contrast, TPCK and TLCK did not block induction of an immediate-early gene encoding the transcription factor , Egr-1 .", "label": " ( protein: Egr-1, None) , ( protein: transcription factor, None) , ( DNA: immediate-early gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Egr-1, None) , ( protein: transcription factor, None) , ( DNA: immediate-early gene, None) " }

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{ "id": "1711", "sentence": "Taken together, these data indicated that inhibiting nuclear translocation of c-Rel /p65 heterodimers prevented LPS induction of TF gene transcription in monocytic cells .", "label": " ( protein: c-Rel /p65 heterodimers, None) , ( protein: c-Rel, None) , ( cell type: monocytic cells, None) , ( protein: /p65, None) , ( protein: TF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c-Rel /p65 heterodimers, None) , ( protein: c-Rel, None) , ( cell type: monocytic cells, None) , ( protein: /p65, None) , ( protein: TF, None) " }

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{ "id": "1712", "sentence": "1,25-Dihydroxyvitamin D3 receptors in peripheral blood mononuclear cells from patients with primary and secondary hyperparathyroidism .", "label": " ( cell type: peripheral blood mononuclear cells, None) , ( protein: 1,25-Dihydroxyvitamin D3 receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral blood mononuclear cells, None) , ( protein: 1,25-Dihydroxyvitamin D3 receptors, None) " }

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{ "id": "1713", "sentence": "A decreased number of calcitriol ( 1,25(OH)2D3 ) receptors has been observed in parathyroid glands of uremic animals .", "label": " ( protein: calcitriol ( 1,25(OH)2D3 ) receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: calcitriol ( 1,25(OH)2D3 ) receptors, None) " }

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{ "id": "1714", "sentence": "In humans , studies carried out in surgically removed parathyroid glands have shown that calcitriol binding is higher in primary than in secondary hyperparathyroidism .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1715", "sentence": "Since specific receptors for calcitriol have been described in peripheral blood mononuclear cells ( PBMC ), we have investigated the specific uptake of 3H-labelled 1,25(OH)2D3 in PBMC of 12 women with primary hyperparathyroidism ( PHP ), 8 women with hyperparathyroidism secondary to chronic renal failure ( SH ), 9 women with renal transplant ( RT ), and 23 healthy women .", "label": " ( cell type: PBMC, None) , ( cell type: PBMC, None) , ( cell type: peripheral blood mononuclear cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PBMC, None) , ( cell type: PBMC, None) , ( cell type: peripheral blood mononuclear cells, None) " }

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{ "id": "1716", "sentence": "The median dissociation constant ( Kd ) was similar in all three groups of patients and in healthy women (mean +/- S.D. (range): PHP , 1.2 +/- 1.0 (0.2-4) x 10(-10) M; SH , 0.6 +/- 0.4 (0.2-1.2) x 10(-10) M; RT , 1.1 +/- 0.5 (0.4-1.9) x 10(-10) M; controls , 1.0 +/- 0.6 (0.3-2.6) x 10(-10) M). However, the maximal binding capacity ( Nmax ) was significantly enhanced in PHP (3.9 +/- 1.9 (1.3-7.6) fmol/10(7) cells vs. 2.3 +/- 0.9 (1.1-4.4) fmol/10(7) cells in controls ; P = 0.0006) and decreased in SH (0.8 +/- 0.5 (0.2-1.6) fmol/10(7) cells vs. 2.3 +/- 0.9 (1.1-4.4) fmol/10(7) cells in controls ; P = 0.0001), whereas no changes were seen in RT (2.3 +/- 0.7 (1.2-3.3) fmol/10(7) cells vs. 2.3 +/- 0.9 (1.1-4.4) fmol/10(7) cells in controls ).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1717", "sentence": "In three patients with PHP who were subjected to parathyroidectomy, the calcitriol number came down to normal.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1718", "sentence": "Changes of calcitriol receptors in primary and secondary hyperparathyroidism could magnify the consequences of disturbances in serum concentration of calcitriol itself and might play an important role in the development of secondary hyperparathyroidism in uremia .", "label": " ( protein: calcitriol receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: calcitriol receptors, None) " }

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{ "id": "1719", "sentence": "The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation .", "label": " ( DNA: tiny ring X chromosomes, None) , ( DNA: chromosomes, None) , ( DNA: X chromosomes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: tiny ring X chromosomes, None) , ( DNA: chromosomes, None) , ( DNA: X chromosomes, None) " }

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{ "id": "1720", "sentence": "Mental retardation and a constellation of congenital malformations not usually associated with Turner syndrome are seen in some females with a mosaic 45,X/46,X,r(X) karyotype .", "label": " ( DNA: mosaic 45,X/46,X,r(X) karyotype, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: mosaic 45,X/46,X,r(X) karyotype, None) " }

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{ "id": "1721", "sentence": "Studies of these females show that the XIST locus on their tiny ring X chromosomes is either not present or not expressed.", "label": " ( DNA: XIST locus, None) , ( DNA: X chromosomes, None) , ( DNA: tiny ring X chromosomes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: XIST locus, None) , ( DNA: X chromosomes, None) , ( DNA: tiny ring X chromosomes, None) " }

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{ "id": "1722", "sentence": "As XIST transcription is well correlated with inactivation of the X chromosome in female somatic cells and spermatogonia , nonexpression of the locus even when it is present suggests that these chromosomes are transcriptionally active .", "label": " ( DNA: XIST, None) , ( cell type: spermatogonia, None) , ( DNA: chromosomes, None) , ( cell type: female somatic cells, None) , ( DNA: X chromosome, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: XIST, None) , ( cell type: spermatogonia, None) , ( DNA: chromosomes, None) , ( cell type: female somatic cells, None) , ( DNA: X chromosome, None) " }

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{ "id": "1723", "sentence": "We examined the transcriptional activity of ring X chromosomes lacking XIST expression (XISTE-), from three females with severe phenotypes.", "label": " ( DNA: XIST, None) , ( DNA: X chromosomes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: XIST, None) , ( DNA: X chromosomes, None) " }

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{ "id": "1724", "sentence": "The two tiny ring X chromosomes studied with an antibody specific for the acetylated isoforms of histone H4 marking transcribed chromatin domains were labeled at a level consistent with their being active.", "label": " ( protein: antibody, None) , ( protein: histone H4, None) , ( DNA: X chromosomes, None) , ( DNA: transcribed chromatin domains, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: antibody, None) , ( protein: histone H4, None) , ( DNA: X chromosomes, None) , ( DNA: transcribed chromatin domains, None) " }

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{ "id": "1725", "sentence": "We also examined tow of the XISTE- ring chromosomes to determine whether genes that are normally silent on an inactive X are expressed from these chromosomes .", "label": " ( DNA: chromosomes, None) , ( DNA: inactive X, None) , ( DNA: XISTE- ring chromosomes, None) , ( DNA: genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: chromosomes, None) , ( DNA: inactive X, None) , ( DNA: XISTE- ring chromosomes, None) , ( DNA: genes, None) " }

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{ "id": "1726", "sentence": "Analyses of hybrid cells show that TIMP , ZXDA , and ZXDB loci on the proximal short arm , and AR and PHKA1 loci on the long arm, are well expressed from the tiny ring X chromosome lacking XIST DNA .", "label": " ( DNA: AR, None) , ( DNA: TIMP, None) , ( DNA: tiny ring X chromosome, None) , ( DNA: XIST DNA, None) , ( DNA: ZXDA, None) , ( DNA: ZXDB loci, None) , ( DNA: X chromosome, None) , ( DNA: proximal short arm, None) , ( DNA: PHKA1 loci, None) , ( cell line: hybrid cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: AR, None) , ( DNA: TIMP, None) , ( DNA: tiny ring X chromosome, None) , ( DNA: XIST DNA, None) , ( DNA: ZXDA, None) , ( DNA: ZXDB loci, None) , ( DNA: X chromosome, None) , ( DNA: proximal short arm, None) , ( DNA: PHKA1 loci, None) , ( cell line: hybrid cells, None) " }

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{ "id": "1727", "sentence": "Studies of the ring chromosome that has XIST DNA but does not transcribe it show that its AR allele is transcribed along with the one on the normal X allele .", "label": " ( DNA: ring chromosome, None) , ( DNA: XIST DNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: ring chromosome, None) , ( DNA: XIST DNA, None) " }

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{ "id": "1728", "sentence": "(ABSTRACT TRUNCATED AT 250 WORDS)", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1729", "sentence": "Inhibition of activation of transcription factor AP-1 by CD28 signalling in human T-cells .", "label": " ( protein: AP-1, None) , ( cell type: human T-cells, None) , ( protein: transcription factor AP-1, None) , ( protein: CD28, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( cell type: human T-cells, None) , ( protein: transcription factor AP-1, None) , ( protein: CD28, None) " }

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{ "id": "1730", "sentence": "Co-stimulation of T-lymphocytes by T-cell receptor ( TcR ) occupancy and activation of the CD28 surface molecule results in enhanced proliferation and interleukin 2 ( IL-2 ) production .", "label": " ( cell type: T-lymphocytes, None) , ( protein: interleukin 2, None) , ( protein: T-cell receptor, None) , ( protein: IL-2, None) , ( protein: TcR, None) , ( protein: CD28 surface molecule, None) , ( protein: CD28, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T-lymphocytes, None) , ( protein: interleukin 2, None) , ( protein: T-cell receptor, None) , ( protein: IL-2, None) , ( protein: TcR, None) , ( protein: CD28 surface molecule, None) , ( protein: CD28, None) " }

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{ "id": "1731", "sentence": "The increase in IL-2 gene expression triggered by CD28 involves a kappa B-like sequence in the 5'-regulatory region of the IL-2 promoter , called CD28 -responsive element .", "label": " ( DNA: IL-2 promoter, None) , ( DNA: kappa B-like sequence, None) , ( protein: CD28, None) , ( DNA: CD28 -responsive element, None) , ( protein: IL-2, None) , ( protein: IL-2, None) , ( protein: CD28, None) , ( DNA: 5#$%#-regulatory region, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IL-2 promoter, None) , ( DNA: kappa B-like sequence, None) , ( protein: CD28, None) , ( DNA: CD28 -responsive element, None) , ( protein: IL-2, None) , ( protein: IL-2, None) , ( protein: CD28, None) , ( DNA: 5#$%#-regulatory region, None) " }

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{ "id": "1732", "sentence": "Stimulation of T-cells by agonistic anti- CD28 antibodies in conjunction with phorbol 12-myristate 13-acetate ( PMA )- or TcR -derived signals induces the enhanced activation of the transcription factor NF-kappa B .", "label": " ( protein: CD28, None) , ( protein: NF-kappa B, None) , ( protein: anti- CD28 antibodies, None) , ( protein: TcR, None) , ( cell type: T-cells, None) , ( protein: transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD28, None) , ( protein: NF-kappa B, None) , ( protein: anti- CD28 antibodies, None) , ( protein: TcR, None) , ( cell type: T-cells, None) , ( protein: transcription factor, None) " }

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{ "id": "1733", "sentence": "Here we report that CD28 engagement, however, exerts opposite effects on the transcription factor AP-1 .", "label": " ( protein: transcription factor, None) , ( protein: AP-1, None) , ( protein: transcription factor AP-1, None) , ( protein: CD28, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor, None) , ( protein: AP-1, None) , ( protein: transcription factor AP-1, None) , ( protein: CD28, None) " }

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{ "id": "1734", "sentence": "Whereas anti- CD28 together with PMA increased the DNA binding and trans-activation activity of NF-kappa B , PMA -induced activation of AP-1 was significantly suppressed.", "label": " ( protein: AP-1, None) , ( protein: CD28, None) , ( protein: NF-kappa B, None) , ( protein: anti- CD28, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( protein: CD28, None) , ( protein: NF-kappa B, None) , ( protein: anti- CD28, None) " }

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{ "id": "1735", "sentence": "The inhibitory effect exerted by anti- CD28 was observed at the level of DNA binding as well as in functional reporter-gene assays .", "label": " ( protein: CD28, None) , ( protein: anti- CD28, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD28, None) , ( protein: anti- CD28, None) " }

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{ "id": "1736", "sentence": "These results suggest that the two transcription factors are independently regulated and may perform different functions during T-cell activation .", "label": " ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) " }

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{ "id": "1737", "sentence": "HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization .", "label": " ( protein: HIV-1 Nef, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HIV-1 Nef, None) , ( cell type: T cells, None) " }

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{ "id": "1738", "sentence": "Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys .", "label": " ( protein: Nef, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Nef, None) " }

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{ "id": "1739", "sentence": "Negative, positive, and no effects of Nef have also been reported on viral replication in cells.", "label": " ( protein: Nef, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Nef, None) " }

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{ "id": "1740", "sentence": "To reconcile these observations, we expressed a hybrid CD8- Nef protein in Jurkat cells .", "label": " ( protein: hybrid CD8- Nef protein, None) , ( protein: Nef, None) , ( cell line: Jurkat cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hybrid CD8- Nef protein, None) , ( protein: Nef, None) , ( cell line: Jurkat cells, None) " }

[]

{ "id": "1741", "sentence": "Two opposite phenotypes were found, which depended on the intracellular localization of Nef .", "label": " ( protein: Nef, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Nef, None) " }

[]

{ "id": "1742", "sentence": "Expressed in the cytoplasm or on the cell surface , the chimera inhibited or activated early signaling events from the T cell antigen receptor .", "label": " ( protein: chimera, None) , ( protein: T cell antigen receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: chimera, None) , ( protein: T cell antigen receptor, None) " }

[]

{ "id": "1743", "sentence": "Activated Jurkat cells died by apoptosis , and only cells with mutated nef genes expressing truncated Nefs survived, which rendered Nef nonfunctional.", "label": " ( DNA: nef genes, None) , ( cell line: Jurkat cells, None) , ( protein: Nef, None) , ( protein: Nefs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: nef genes, None) , ( cell line: Jurkat cells, None) , ( protein: Nef, None) , ( protein: Nefs, None) " }

[]

{ "id": "1744", "sentence": "These mutations paralleled those in other viral strains passaged in vitro.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1745", "sentence": "Not only do these positional effects of Nef reconcile diverse phenotypes of Nef and suggest a role for its N-terminal myristylation , but they also explain effects of Nef in HIV infection and progression to AIDS .", "label": " ( protein: Nef, None) , ( protein: Nef, None) , ( protein: Nef, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Nef, None) , ( protein: Nef, None) , ( protein: Nef, None) " }

[]

{ "id": "1746", "sentence": "An intricate arrangement of binding sites for the Ets family of transcription factors regulates activity of the alpha 4 integrin gene promoter .", "label": " ( protein: Ets family, None) , ( protein: transcription factors, None) , ( DNA: alpha 4 integrin gene promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Ets family, None) , ( protein: transcription factors, None) , ( DNA: alpha 4 integrin gene promoter, None) " }

[]

{ "id": "1747", "sentence": "alpha 4 integrins mediate cell-cell and cell-extracellular matrix interactions that are critical for maturation and function of the immune system as well as differentiation of skeletal muscle .", "label": " ( protein: alpha 4 integrins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: alpha 4 integrins, None) " }

[]

{ "id": "1748", "sentence": "Here we examine molecular mechanisms controlling the pattern of alpha 4 expression .", "label": " ( protein: alpha 4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: alpha 4, None) " }

[]

{ "id": "1749", "sentence": "The activity of constructs containing 5' deletion mutants of the alpha 4 gene promoter was compared in transfection assays into cell lines that express alpha 4 and cell lines that do not.", "label": " ( protein: alpha 4, None) , ( cell line: cell lines, None) , ( cell line: cell lines, None) , ( DNA: alpha 4 gene promoter, None) , ( DNA: 5#$%# deletion mutants, None) , ( protein: alpha 4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: alpha 4, None) , ( cell line: cell lines, None) , ( cell line: cell lines, None) , ( DNA: alpha 4 gene promoter, None) , ( DNA: 5#$%# deletion mutants, None) , ( protein: alpha 4, None) " }

[]

{ "id": "1750", "sentence": "The sequence between position -42 and -76 base pairs (bp) was required for efficient transcription in cells that express alpha 4 , but it showed no activity in HeLa cells , which do not express alpha 4 .", "label": " ( cell line: HeLa cells, None) , ( DNA: -42 and -76 base pairs, None) , ( protein: alpha 4, None) , ( protein: alpha 4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HeLa cells, None) , ( DNA: -42 and -76 base pairs, None) , ( protein: alpha 4, None) , ( protein: alpha 4, None) " }

[]

{ "id": "1751", "sentence": "Three binding sites for the Ets family of transcription factors are found in this region: two adjacent sites at positions -50 and -54 bp and a more 5' site at position -67 bp .", "label": " ( protein: Ets family, None) , ( DNA: -50 and -54 bp, None) , ( DNA: -67 bp, None) , ( protein: transcription factors, None) , ( DNA: 5#$%# site, None) , ( DNA: binding sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Ets family, None) , ( DNA: -50 and -54 bp, None) , ( DNA: -67 bp, None) , ( protein: transcription factors, None) , ( DNA: 5#$%# site, None) , ( DNA: binding sites, None) " }

[]

{ "id": "1752", "sentence": "Using a series of constructs containing deletions and mutations in this region, we found that the 3'-most site alone was sufficient for binding GA-binding protein alpha ( GABP alpha )/ GABP beta and for a low level of transcriptional activation .", "label": " ( protein: GABP alpha )/ GABP beta, None) , ( protein: GABP beta, None) , ( DNA: 3#$%#-most site, None) , ( protein: GABP alpha, None) , ( protein: GA-binding protein alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GABP alpha )/ GABP beta, None) , ( protein: GABP beta, None) , ( DNA: 3#$%#-most site, None) , ( protein: GABP alpha, None) , ( protein: GA-binding protein alpha, None) " }

[]

{ "id": "1753", "sentence": "When all three sites were present, a second complex \"a\" was detected, which contains an unknown member of the Ets family .", "label": " ( protein: Ets family, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Ets family, None) " }

[]

{ "id": "1754", "sentence": "Formation of complex a was cell-type specific and correlated with a high level of transcription.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1755", "sentence": "Deletion of the 5'-most Ets site had no effect on binding to GABP alpha/GABP beta , but it eliminated a.", "label": " ( DNA: 5#$%#-most Ets site, None) , ( protein: GABP alpha/GABP beta, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: 5#$%#-most Ets site, None) , ( protein: GABP alpha/GABP beta, None) " }

[]

{ "id": "1756", "sentence": "Concomitant with this loss of a, a new Ets-1-containing complex \" c \" appeared.", "label": " ( protein: c, None) , ( protein: new Ets-1-containing complex, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c, None) , ( protein: new Ets-1-containing complex, None) " }

[]

{ "id": "1757", "sentence": "Complex c substituted efficiently for complex a in transcriptional activation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1758", "sentence": "We conclude that although neither of the two 5'-most Ets sites alone binds nuclear protein , they appear to act as modulators which control the pattern of Ets proteins that bind the alpha 4 gene promoter .", "label": " ( protein: alpha 4, None) , ( DNA: alpha 4 gene promoter, None) , ( protein: nuclear protein, None) , ( protein: Ets proteins, None) , ( DNA: 5#$%#-most Ets sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: alpha 4, None) , ( DNA: alpha 4 gene promoter, None) , ( protein: nuclear protein, None) , ( protein: Ets proteins, None) , ( DNA: 5#$%#-most Ets sites, None) " }

[]

{ "id": "1759", "sentence": "This arrangement of Ets sites , coupled with the tissue- and developmental-specific expression of Ets members , likely play a key role in defining the pattern of alpha 4 integrin .", "label": " ( protein: alpha 4 integrin, None) , ( protein: Ets members, None) , ( DNA: Ets sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: alpha 4 integrin, None) , ( protein: Ets members, None) , ( DNA: Ets sites, None) " }

[]

{ "id": "1760", "sentence": "Mechanism of antiandrogen action : conformational changes of the receptor.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1761", "sentence": "Androgen receptor mRNA was translated in vitro, and androgen- and antiandrogen- bound receptor complexes were studied using limited proteolytic digestion by trypsin .", "label": " ( protein: Androgen receptor, None) , ( RNA: Androgen receptor mRNA, None) , ( protein: trypsin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Androgen receptor, None) , ( RNA: Androgen receptor mRNA, None) , ( protein: trypsin, None) " }

[]

{ "id": "1762", "sentence": "Partial proteolysis of androgen -bound receptor protein resulted in a 29-kDa proteolysis-resisting fragment , whereas antiandrogen binding stabilised a 35-kDa fragment .", "label": " ( protein: 35-kDa fragment, None) , ( protein: androgen -bound receptor protein, None) , ( protein: 29-kDa proteolysis-resisting fragment, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: 35-kDa fragment, None) , ( protein: androgen -bound receptor protein, None) , ( protein: 29-kDa proteolysis-resisting fragment, None) " }

[]

{ "id": "1763", "sentence": "Both fragments contain the entire ligand binding domain , and the 35-kDa fragment extended into the hinge region of the receptor.", "label": " ( protein: 35-kDa fragment, None) , ( protein: ligand binding domain, None) , ( protein: hinge region, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: 35-kDa fragment, None) , ( protein: ligand binding domain, None) , ( protein: hinge region, None) " }

[]

{ "id": "1764", "sentence": "Several antiandrogens show agonistic properties for a mutated androgen receptor ( LNCaP cell variant ); trypsin digestion of antiandrogen -bound mutated receptor also resulted in a 29-kDa fragment .", "label": " ( protein: trypsin, None) , ( protein: antiandrogen -bound mutated receptor, None) , ( cell line: LNCaP cell variant, None) , ( protein: 29-kDa fragment, None) , ( protein: mutated androgen receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: trypsin, None) , ( protein: antiandrogen -bound mutated receptor, None) , ( cell line: LNCaP cell variant, None) , ( protein: 29-kDa fragment, None) , ( protein: mutated androgen receptor, None) " }

[]

{ "id": "1765", "sentence": "Our results point to an important difference between antiandrogens and antagonists of other steroid hormone receptors .", "label": " ( protein: steroid hormone receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: steroid hormone receptors, None) " }

[]

{ "id": "1766", "sentence": "Antiandrogens result in protection of both the hinge region and C-terminus of the androgen receptor agonist proteolytic attack , whereas other studies showed that antiestrogens and antiprogestagens expose the C-terminal end of the ligand binding domain of their respective receptors to protease .", "label": " ( protein: ligand binding domain, None) , ( protein: hinge region, None) , ( protein: C-terminus, None) , ( protein: C-terminal end, None) , ( protein: protease, None) , ( protein: androgen receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ligand binding domain, None) , ( protein: hinge region, None) , ( protein: C-terminus, None) , ( protein: C-terminal end, None) , ( protein: protease, None) , ( protein: androgen receptor, None) " }

[]

{ "id": "1767", "sentence": "Differences in conformation of the hinge region distinguish androgen -bound from antiandrogen -bound receptor complexes , which represents an important feature of antiandrogen action .", "label": " ( protein: hinge region, None) , ( protein: antiandrogen -bound receptor complexes, None) , ( protein: androgen -bound, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hinge region, None) , ( protein: antiandrogen -bound receptor complexes, None) , ( protein: androgen -bound, None) " }

[]

{ "id": "1768", "sentence": "Activation of nuclear factor kappa B in human neuroblastoma cell lines .", "label": " ( protein: nuclear factor kappa B, None) , ( cell line: neuroblastoma cell lines, None) , ( cell line: human neuroblastoma cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor kappa B, None) , ( cell line: neuroblastoma cell lines, None) , ( cell line: human neuroblastoma cell lines, None) " }

[]

{ "id": "1769", "sentence": "The nuclear factor kappa B ( NF-kappa B ) is a eukaryotic transcription factor .", "label": " ( protein: NF-kappa B, None) , ( protein: nuclear factor kappa B, None) , ( protein: transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: nuclear factor kappa B, None) , ( protein: transcription factor, None) " }

[]

{ "id": "1770", "sentence": "In B cells and macrophages it is constitutively present in cell nuclei, whereas in many other cell types, NF-kappa B translocates from cytosol to nucleus as a result of transduction by tumor necrosis factor alpha ( TNF alpha ), phorbol ester , and other polyclonal signals .", "label": " ( cell type: B cells, None) , ( protein: TNF alpha, None) , ( protein: NF-kappa B, None) , ( protein: tumor necrosis factor alpha, None) , ( cell type: macrophages, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B cells, None) , ( protein: TNF alpha, None) , ( protein: NF-kappa B, None) , ( protein: tumor necrosis factor alpha, None) , ( cell type: macrophages, None) " }

[]

{ "id": "1771", "sentence": "Using neuroblastoma cell lines as models, we have shown that in neural cells NF-kappa B was present in the cytosol and translocated into nuclei as a result of TNF alpha treatment .", "label": " ( protein: NF-kappa B, None) , ( cell line: neuroblastoma cell lines, None) , ( protein: TNF alpha, None) , ( cell type: neural cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( cell line: neuroblastoma cell lines, None) , ( protein: TNF alpha, None) , ( cell type: neural cells, None) " }

[]

{ "id": "1772", "sentence": "The TNF alpha -activated NF-kappa B was transcriptionally functional.", "label": " ( protein: TNF alpha, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF alpha, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "1773", "sentence": "NF-kappa B activation by TNF alpha was not correlated with cell differentiation or proliferation .", "label": " ( protein: TNF alpha, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF alpha, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "1774", "sentence": "However, reagents such as nerve growth factor ( NGF ) and the phorbol ester phorbol 12-myristate 13-acetate ( PMA ), which induce phenotypical differentiation of the SH-SY5Y neuroblastoma cell line , activated NF-kappa B , but only in that particular cell line .", "label": " ( cell line: cell line, None) , ( cell line: SH-SY5Y neuroblastoma cell line, None) , ( protein: NF-kappa B, None) , ( protein: nerve growth factor, None) , ( protein: NGF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: cell line, None) , ( cell line: SH-SY5Y neuroblastoma cell line, None) , ( protein: NF-kappa B, None) , ( protein: nerve growth factor, None) , ( protein: NGF, None) " }

[]

{ "id": "1775", "sentence": "In a NGF -responsive rat pheochromocytoma cell line , PC12 , PMA activated NF-kappa B , whereas NGF did not.", "label": " ( protein: NF-kappa B, None) , ( protein: NGF, None) , ( cell line: NGF -responsive rat pheochromocytoma cell line, None) , ( cell line: PC12, None) , ( protein: NGF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: NGF, None) , ( cell line: NGF -responsive rat pheochromocytoma cell line, None) , ( cell line: PC12, None) , ( protein: NGF, None) " }

[]

{ "id": "1776", "sentence": "In other neuroblastoma cell lines , such as SK-N-Be(2) , the lack of PMA induction of differentiation was correlated with the lack of NF-kappa B activation .", "label": " ( protein: NF-kappa B, None) , ( cell line: neuroblastoma cell lines, None) , ( cell line: SK-N-Be(2), None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( cell line: neuroblastoma cell lines, None) , ( cell line: SK-N-Be(2), None) " }

[]

{ "id": "1777", "sentence": "We found, moreover, that in SK-N-Be(2) cells protein kinase C ( PKC ) enzymatic activity was much lower compared with that in a control cell line and that the low PKC enzymatic activity was due to low PKC protein expression .", "label": " ( protein: PKC, None) , ( protein: protein kinase C, None) , ( protein: PKC, None) , ( protein: PKC, None) , ( cell line: SK-N-Be(2) cells, None) , ( cell line: control cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC, None) , ( protein: protein kinase C, None) , ( protein: PKC, None) , ( protein: PKC, None) , ( cell line: SK-N-Be(2) cells, None) , ( cell line: control cell line, None) " }

[]

{ "id": "1778", "sentence": "NF-kappa B was not activated by retinoic acid , which induced morphological differentiation of all the neuroblastoma cell lines used in the present study.", "label": " ( protein: NF-kappa B, None) , ( cell line: neuroblastoma cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( cell line: neuroblastoma cell lines, None) " }

[]

{ "id": "1779", "sentence": "Thus, NF-kappa B activation was not required for neuroblastoma cell differentiation .", "label": " ( cell type: neuroblastoma, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: neuroblastoma, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "1780", "sentence": "Furthermore, the results obtained with TNF alpha proved that NF-kappa B activation was not sufficient for induction of neuroblastoma differentiation .", "label": " ( cell type: neuroblastoma, None) , ( protein: TNF alpha, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: neuroblastoma, None) , ( protein: TNF alpha, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "1781", "sentence": "ERP , a new member of the ets transcription factor/oncoprotein family : cloning , characterization , and differential expression during B-lymphocyte development .", "label": " ( protein: ERP, None) , ( protein: ets transcription factor/oncoprotein family, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ERP, None) , ( protein: ets transcription factor/oncoprotein family, None) " }

[]

{ "id": "1782", "sentence": "The ets gene family encodes a group of proteins which function as transcription factors under physiological conditions and, if aberrantly expressed, can cause cellular transformation .", "label": " ( DNA: ets gene family, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: ets gene family, None) , ( protein: transcription factors, None) " }

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{ "id": "1783", "sentence": "We have recently identified two regulatory elements in the murine immunoglobulin heavy-chain (IgH) enhancer , pi and microB , which exhibit striking similarity to binding sites for ets-related proteins .", "label": " ( DNA: ets-related proteins, None) , ( DNA: microB, None) , ( DNA: pi, None) , ( DNA: binding sites, None) , ( DNA: murine immunoglobulin heavy-chain (IgH) enhancer, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: ets-related proteins, None) , ( DNA: microB, None) , ( DNA: pi, None) , ( DNA: binding sites, None) , ( DNA: murine immunoglobulin heavy-chain (IgH) enhancer, None) " }

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{ "id": "1784", "sentence": "To identify ets-related transcriptional regulators expressed in pre-B lymphocytes that may interact with either the pi or the microB site , we have used a PCR approach with degenerate oligonucleotides encoding conserved sequences in all members of the ets family .", "label": " ( cell type: pre-B lymphocytes, None) , ( protein: ets-related transcriptional regulators, None) , ( DNA: microB site, None) , ( DNA: ets family, None) , ( DNA: microB, None) , ( DNA: pi, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: pre-B lymphocytes, None) , ( protein: ets-related transcriptional regulators, None) , ( DNA: microB site, None) , ( DNA: ets family, None) , ( DNA: microB, None) , ( DNA: pi, None) " }

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{ "id": "1785", "sentence": "We have cloned the gene for a new ets-related transcription factor , ERP ( ets-related protein ), from the murine pre-B cell line BASC 6C2 and from mouse lung tissue .", "label": " ( cell line: murine pre-B cell line, None) , ( protein: transcription factor, None) , ( protein: ets-related protein, None) , ( protein: ERP, None) , ( cell line: BASC 6C2, None) , ( protein: ets-related transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: murine pre-B cell line, None) , ( protein: transcription factor, None) , ( protein: ets-related protein, None) , ( protein: ERP, None) , ( cell line: BASC 6C2, None) , ( protein: ets-related transcription factor, None) " }

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{ "id": "1786", "sentence": "The ERP protein contains a region of high homology with the ETS DNA-binding domain common to all members of the ets transcription factor/oncoprotein family .", "label": " ( protein: ets transcription factor/oncoprotein family, None) , ( protein: ERP, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ets transcription factor/oncoprotein family, None) , ( protein: ERP, None) " }

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{ "id": "1787", "sentence": "Three additional smaller regions show homology to the ELK-1 and SAP-1 genes, a subgroup of the ets gene family that interacts with the serum response factor .", "label": " ( protein: SAP-1, None) , ( DNA: ets gene family, None) , ( protein: serum response factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: SAP-1, None) , ( DNA: ets gene family, None) , ( protein: serum response factor, None) " }

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{ "id": "1788", "sentence": "Full-length ERP expresses only negligible DNA-binding activity by itself.", "label": " ( protein: ERP, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ERP, None) " }

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{ "id": "1789", "sentence": "Removal of the carboxy terminus enables ERP to interact with a variety of ets-binding sites including the E74 site , the IgH enhancer pi site , and the lck promoter ets site , suggesting a carboxy-terminal negative regulatory domain .", "label": " ( DNA: lck promoter ets site, None) , ( DNA: ets-binding sites, None) , ( protein: ERP, None) , ( DNA: E74 site, None) , ( protein: carboxy-terminal negative regulatory domain, None) , ( protein: carboxy terminus, None) , ( DNA: IgH enhancer pi site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: lck promoter ets site, None) , ( DNA: ets-binding sites, None) , ( protein: ERP, None) , ( DNA: E74 site, None) , ( protein: carboxy-terminal negative regulatory domain, None) , ( protein: carboxy terminus, None) , ( DNA: IgH enhancer pi site, None) " }

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{ "id": "1790", "sentence": "At least three ERP -related transcripts are expressed in a variety of tissues.", "label": " ( protein: ERP, None) , ( protein: ERP -related transcripts, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ERP, None) , ( protein: ERP -related transcripts, None) " }

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{ "id": "1791", "sentence": "However, within the B-cell lineage , ERP is highly expressed primarily at early stages of B-lymphocyte development , and expression declines drastically upon B-cell maturation , correlating with the enhancer activity of the IgH pi site .", "label": " ( DNA: IgH pi site, None) , ( cell type: B-lymphocyte, None) , ( protein: ERP, None) , ( cell type: B-cell lineage, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IgH pi site, None) , ( cell type: B-lymphocyte, None) , ( protein: ERP, None) , ( cell type: B-cell lineage, None) " }

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{ "id": "1792", "sentence": "These data suggest that ERP might play a role in B-cell development and in IgH gene regulation .", "label": " ( cell type: B-cell, None) , ( DNA: IgH gene, None) , ( protein: ERP, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B-cell, None) , ( DNA: IgH gene, None) , ( protein: ERP, None) " }

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{ "id": "1793", "sentence": "Gene for a tissue-specific transcriptional activator ( EBF or Olf-1 ), expressed in early B lymphocytes , adipocytes , and olfactory neurons , is located on human chromosome 5 , band q34 , and proximal mouse chromosome 11 .", "label": " ( protein: EBF, None) , ( DNA: band q34, None) , ( cell type: olfactory neurons, None) , ( cell type: early B lymphocytes, None) , ( DNA: proximal mouse chromosome 11, None) , ( DNA: human chromosome 5, None) , ( protein: tissue-specific transcriptional activator, None) , ( protein: Olf-1, None) , ( cell type: adipocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: EBF, None) , ( DNA: band q34, None) , ( cell type: olfactory neurons, None) , ( cell type: early B lymphocytes, None) , ( DNA: proximal mouse chromosome 11, None) , ( DNA: human chromosome 5, None) , ( protein: tissue-specific transcriptional activator, None) , ( protein: Olf-1, None) , ( cell type: adipocytes, None) " }

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{ "id": "1794", "sentence": "Murine B lymphocytes , adipocytes , and olfactory neurons contain a DNA-binding protein that participates in the regulation of genes encoding tissue-specific components of signal transduction .", "label": " ( cell type: adipocytes, None) , ( DNA: genes, None) , ( cell type: Murine B lymphocytes, None) , ( protein: DNA-binding protein, None) , ( cell type: olfactory neurons, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: adipocytes, None) , ( DNA: genes, None) , ( cell type: Murine B lymphocytes, None) , ( protein: DNA-binding protein, None) , ( cell type: olfactory neurons, None) " }

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{ "id": "1795", "sentence": "Purification and cloning of this protein, termed early B-cell factor ( EBF ), from murine B lymphocytes and independent cloning of a protein, termed Olf-1 , from olfactory neuronal cells revealed virtual complete amino acid sequence identity between these proteins.", "label": " ( protein: B-cell factor, None) , ( protein: amino acid sequence, None) , ( cell type: olfactory neuronal cells, None) , ( protein: EBF, None) , ( cell type: murine B lymphocytes, None) , ( protein: Olf-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: B-cell factor, None) , ( protein: amino acid sequence, None) , ( cell type: olfactory neuronal cells, None) , ( protein: EBF, None) , ( cell type: murine B lymphocytes, None) , ( protein: Olf-1, None) " }

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{ "id": "1796", "sentence": "As a first step towards identifying a human genetic disorder or mouse mutation for which EBF could be a candidate gene, we have chromosomally mapped the corresponding locus in both species.", "label": " ( protein: EBF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: EBF, None) " }

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{ "id": "1797", "sentence": "By Southern hybridization analyses of somatic cell hybrid panels with murine cDNA probe , fluorescence chromosomal in situ hybridization ( FISH ) of human genomic clones , and analysis of recombinant inbred mouse strains , we have found single sites for EBF homologous sequences on human Chromosome (Chr) 5, band q34 , and on proximal mouse Chr 11 , in an evolutionarily conserved region .", "label": " ( DNA: band q34, None) , ( protein: EBF, None) , ( DNA: murine cDNA probe, None) , ( DNA: proximal mouse Chr 11, None) , ( DNA: evolutionarily conserved region, None) , ( DNA: EBF homologous sequences, None) , ( DNA: human genomic clones, None) , ( cell line: recombinant inbred mouse strains, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: band q34, None) , ( protein: EBF, None) , ( DNA: murine cDNA probe, None) , ( DNA: proximal mouse Chr 11, None) , ( DNA: evolutionarily conserved region, None) , ( DNA: EBF homologous sequences, None) , ( DNA: human genomic clones, None) , ( cell line: recombinant inbred mouse strains, None) " }

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{ "id": "1798", "sentence": "Calcineurin activates transcription from the GM-CSF promoter in synergy with either protein kinase C or NF-kappa B /AP-1 in T cells .", "label": " ( DNA: GM-CSF promoter, None) , ( cell type: T cells, None) , ( protein: protein kinase C, None) , ( protein: Calcineurin, None) , ( protein: NF-kappa B, None) , ( protein: /AP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: GM-CSF promoter, None) , ( cell type: T cells, None) , ( protein: protein kinase C, None) , ( protein: Calcineurin, None) , ( protein: NF-kappa B, None) , ( protein: /AP-1, None) " }

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{ "id": "1799", "sentence": "Two cis-acting elements GM-kappa B/GC-box and CLE0 , of the granulocyte-macrophage colony-stimulating factor ( GM-CSF ) gene are required for maximal induction in Jurkat T cells by costimulation with phorbol-12-myristate acetate ( PMA ) and Ca2+ ionophore ( A23187 ).", "label": " ( protein: GM-CSF, None) , ( DNA: GM-kappa B/GC-box, None) , ( DNA: granulocyte-macrophage colony-stimulating factor ( GM-CSF ) gene, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( cell line: Jurkat T cells, None) , ( DNA: cis-acting elements, None) , ( DNA: CLE0, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GM-CSF, None) , ( DNA: GM-kappa B/GC-box, None) , ( DNA: granulocyte-macrophage colony-stimulating factor ( GM-CSF ) gene, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( cell line: Jurkat T cells, None) , ( DNA: cis-acting elements, None) , ( DNA: CLE0, None) " }