Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "1800", "sentence": "The GM-kappa B sequence is recognized by NF-kappa B , which is mainly induced by PMA .", "label": " ( protein: NF-kappa B, None) , ( DNA: GM-kappa B sequence, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( DNA: GM-kappa B sequence, None) " }

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{ "id": "1801", "sentence": "The CLE0 sequence interacts with factors, related to a PMA -induced AP-1 and a PMA / A23187 -induced NF-AT .", "label": " ( protein: PMA -induced AP-1, None) , ( DNA: CLE0 sequence, None) , ( protein: AP-1, None) , ( protein: PMA / A23187 -induced NF-AT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PMA -induced AP-1, None) , ( DNA: CLE0 sequence, None) , ( protein: AP-1, None) , ( protein: PMA / A23187 -induced NF-AT, None) " }

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{ "id": "1802", "sentence": "We examined whether signal transducing components in T cells can activate transcription of the GM-CSF gene .", "label": " ( cell type: T cells, None) , ( DNA: GM-CSF gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( DNA: GM-CSF gene, None) " }

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{ "id": "1803", "sentence": "Cotransfection of NF-kappa B (p50/p65)- or AP-1 (c-Jun/c-Fos)- expression vectors into Jurkat cells with a luciferase reporter containing the GM-CSF promoter did not stimulate transcription from the GM-CSF promoter .", "label": " ( DNA: GM-CSF promoter, None) , ( cell line: Jurkat cells, None) , ( DNA: luciferase reporter, None) , ( DNA: GM-CSF promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: GM-CSF promoter, None) , ( cell line: Jurkat cells, None) , ( DNA: luciferase reporter, None) , ( DNA: GM-CSF promoter, None) " }

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{ "id": "1804", "sentence": "In contrast, cotransfection with a combination of NF-kappa B and AP-1 significantly augmented transcription from the GM-CSF promoter containing the GM-kappa B/GC-box and the CLE0 ( AP-1 /NF-AT ).", "label": " ( protein: AP-1, None) , ( DNA: GM-CSF promoter, None) , ( protein: NF-kappa B, None) , ( protein: AP-1 /NF-AT, None) , ( protein: AP-1, None) , ( DNA: GM-kappa B/GC-box, None) , ( DNA: CLE0, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( DNA: GM-CSF promoter, None) , ( protein: NF-kappa B, None) , ( protein: AP-1 /NF-AT, None) , ( protein: AP-1, None) , ( DNA: GM-kappa B/GC-box, None) , ( DNA: CLE0, None) " }

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{ "id": "1805", "sentence": "Expression of a constitutively active calcineurin ( CN ), a Ca2+ /calmodulin-dependent protein phosphatase , potentiated by two fold the transcriptional activation by NF-kappa B /AP-1 .", "label": " ( protein: Ca2+ /calmodulin-dependent protein phosphatase, None) , ( protein: NF-kappa B, None) , ( protein: calcineurin, None) , ( protein: /AP-1, None) , ( protein: CN, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Ca2+ /calmodulin-dependent protein phosphatase, None) , ( protein: NF-kappa B, None) , ( protein: calcineurin, None) , ( protein: /AP-1, None) , ( protein: CN, None) " }

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{ "id": "1806", "sentence": "Both constitutively active forms of CN and protein kinase C ( PKC ) synergistically activated transcription from the GM-CSF promoter .", "label": " ( protein: PKC, None) , ( DNA: GM-CSF promoter, None) , ( protein: protein kinase C, None) , ( protein: CN, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC, None) , ( DNA: GM-CSF promoter, None) , ( protein: protein kinase C, None) , ( protein: CN, None) " }

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{ "id": "1807", "sentence": "These results suggest that cooperation among NF-kappa B- , AP-1- and NF-AT- binding sequences is required for induction of the GM-CSF gene through PKC- and Ca2+- signaling pathways downstream of T cell activation.", "label": " ( DNA: GM-CSF gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: GM-CSF gene, None) " }

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{ "id": "1808", "sentence": "Nonpituitary human prolactin gene transcription is independent of Pit-1 and differentially controlled in lymphocytes and in endometrial stroma .", "label": " ( cell type: lymphocytes, None) , ( DNA: Nonpituitary human prolactin gene, None) , ( protein: Pit-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphocytes, None) , ( DNA: Nonpituitary human prolactin gene, None) , ( protein: Pit-1, None) " }

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{ "id": "1809", "sentence": "Expression of the human PRL (hPRL) gene in extrapituitary sites such as the uterus (decidualized endometrial stroma and myometrium ) and cells of the hematopoietic lineage is directed by an alternative promoter which is located approximately 6 kilobases (kb) upstream of the pituitary-specific start site .", "label": " ( DNA: 6 kilobases (kb) upstream, None) , ( DNA: alternative promoter, None) , ( cell type: hematopoietic lineage, None) , ( DNA: human PRL (hPRL) gene, None) , ( DNA: pituitary-specific start site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: 6 kilobases (kb) upstream, None) , ( DNA: alternative promoter, None) , ( cell type: hematopoietic lineage, None) , ( DNA: human PRL (hPRL) gene, None) , ( DNA: pituitary-specific start site, None) " }

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{ "id": "1810", "sentence": "In order to delineate the tissue-specific mechanisms governing the control of nonpituitary PRL gene expression , we have cloned and sequenced 3 kb 5'-flanking DNA of the upstream decidual/lymphoid (dPRL) promoter .", "label": " ( DNA: decidual/lymphoid (dPRL) promoter, None) , ( DNA: 3 kb 5#$%#-flanking DNA, None) , ( DNA: PRL gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: decidual/lymphoid (dPRL) promoter, None) , ( DNA: 3 kb 5#$%#-flanking DNA, None) , ( DNA: PRL gene, None) " }

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{ "id": "1811", "sentence": "Based on sequence homology we identified two binding motifs for Pit-1 and seven half-sites for glucocorticoid receptor/progesterone receptor ( PR ) binding .", "label": " ( protein: PR, None) , ( DNA: binding motifs, None) , ( protein: Pit-1, None) , ( DNA: half-sites, None) , ( protein: glucocorticoid receptor/progesterone receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PR, None) , ( DNA: binding motifs, None) , ( protein: Pit-1, None) , ( DNA: half-sites, None) , ( protein: glucocorticoid receptor/progesterone receptor, None) " }

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{ "id": "1812", "sentence": "We focused our studies on the role of Pit-1 and of PR as potential transcriptional regulators , since the POU domain protein Pit-1 is essential in the control of pituitary PRL expression , and progesterone induces decidual transformation of the endometrial stroma , a differentiation process during which the decidual PRL gene is activated.", "label": " ( DNA: PRL gene, None) , ( protein: transcriptional regulators, None) , ( protein: PR, None) , ( protein: Pit-1, None) , ( protein: POU domain protein, None) , ( DNA: Pit-1, None) , ( protein: PRL, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: PRL gene, None) , ( protein: transcriptional regulators, None) , ( protein: PR, None) , ( protein: Pit-1, None) , ( protein: POU domain protein, None) , ( DNA: Pit-1, None) , ( protein: PRL, None) " }

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{ "id": "1813", "sentence": "We demonstrate in a variety of cell types, including lymphocytes and endometrial stroma , that Pit-1 is not involved in the regulation of dPRL promoter/reporter gene constructs carrying 3 kb 5'-flanking DNA .", "label": " ( DNA: dPRL promoter/reporter gene constructs, None) , ( DNA: 3 kb 5#$%#-flanking DNA, None) , ( protein: Pit-1, None) , ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: dPRL promoter/reporter gene constructs, None) , ( DNA: 3 kb 5#$%#-flanking DNA, None) , ( protein: Pit-1, None) , ( cell type: lymphocytes, None) " }

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{ "id": "1814", "sentence": "Our experiments also show that activated PR does not confer direct transcriptional control on the dPRL promoter .", "label": " ( DNA: dPRL promoter, None) , ( protein: PR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: dPRL promoter, None) , ( protein: PR, None) " }

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{ "id": "1815", "sentence": "When we compared the activity of the transfected dPRL promoter in PRL- secreting and nonsecreting lymphoid cells , we found that the 3 kb 5'-flanking region of the dPRL promoter did not contain elements restricting expression to only those lymphocytes that produce PRL but allowed expression of fusion reporter genes irrespective of the status of the endogenous PRL gene .", "label": " ( DNA: dPRL promoter, None) , ( cell type: lymphocytes, None) , ( protein: PRL, None) , ( DNA: 3 kb 5#$%#-flanking region, None) , ( DNA: dPRL promoter, None) , ( DNA: PRL gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: dPRL promoter, None) , ( cell type: lymphocytes, None) , ( protein: PRL, None) , ( DNA: 3 kb 5#$%#-flanking region, None) , ( DNA: dPRL promoter, None) , ( DNA: PRL gene, None) " }

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{ "id": "1816", "sentence": "This was in sharp contrast to endometrial cells where 3 kb 5'-flanking DNA conferred strong transcriptional activation on the dPRL promoter in decidualized endometrial stromal cells actively secreting PRL , but did not allow transcription in undifferentiated non-PRL-secreting endometrial stromal cells .", "label": " ( protein: PRL, None) , ( cell type: non-PRL-secreting endometrial stromal cells, None) , ( cell type: endometrial stromal cells, None) , ( DNA: dPRL promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PRL, None) , ( cell type: non-PRL-secreting endometrial stromal cells, None) , ( cell type: endometrial stromal cells, None) , ( DNA: dPRL promoter, None) " }

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{ "id": "1817", "sentence": "Activation of the dPRL promoter construct in these undifferentiated cells could however be induced by the addition of cAMP , in the absence of progesterone , suggesting that a signal transduced through the cAMP signaling pathway is a primary inducer of decidual PRL gene expression .", "label": " ( DNA: dPRL promoter, None) , ( DNA: PRL gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: dPRL promoter, None) , ( DNA: PRL gene, None) " }

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{ "id": "1818", "sentence": "Signals and nuclear factors that regulate the expression of interleukin-4 and interleukin-5 genes in helper T cells .", "label": " ( cell type: helper T cells, None) , ( protein: nuclear factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: helper T cells, None) , ( protein: nuclear factors, None) " }

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{ "id": "1819", "sentence": "Mouse thymoma line EL-4 cells produce cytokines such as interleukin (IL)-2 , IL-3 , IL-4 , IL-10 , and granulocyte-macrophage colony-stimulating factor in response to phorbol 12-myristate 13-acetate ( PMA ).", "label": " ( cell line: Mouse thymoma line EL-4 cells, None) , ( protein: IL-4, None) , ( protein: interleukin (IL)-2, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( protein: IL-3, None) , ( protein: cytokines, None) , ( cell line: EL-4 cells, None) , ( protein: IL-10, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Mouse thymoma line EL-4 cells, None) , ( protein: IL-4, None) , ( protein: interleukin (IL)-2, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( protein: IL-3, None) , ( protein: cytokines, None) , ( cell line: EL-4 cells, None) , ( protein: IL-10, None) " }

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{ "id": "1820", "sentence": "EL-4 cells also produce low levels of IL-5 when stimulated by PMA alone; however, cAMP greatly augments PMA -dependent IL-5 production .", "label": " ( cell line: EL-4 cells, None) , ( protein: IL-5, None) , ( protein: IL-5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: EL-4 cells, None) , ( protein: IL-5, None) , ( protein: IL-5, None) " }

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{ "id": "1821", "sentence": "A transient transfection assay revealed that two signals, PMA and cAMP , are required for optimal activation of the IL-5 promoter .", "label": " ( protein: IL-5, None) , ( DNA: IL-5 promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-5, None) , ( DNA: IL-5 promoter, None) " }

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{ "id": "1822", "sentence": "In contrast, cAMP almost completely inhibited the PMA -dependent activation of the endogenous IL-2 gene , as well as the transfected IL-2 promoter .", "label": " ( DNA: IL-2 gene, None) , ( DNA: endogenous IL-2 gene, None) , ( protein: IL-2, None) , ( DNA: IL-2 promoter, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IL-2 gene, None) , ( DNA: endogenous IL-2 gene, None) , ( protein: IL-2, None) , ( DNA: IL-2 promoter, None) , ( protein: IL-2, None) " }

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{ "id": "1823", "sentence": "These results indicate that the IL-5 gene is positively regulated by cAMP in a manner opposite to that for the IL-2 gene .", "label": " ( protein: IL-5, None) , ( DNA: IL-5 gene, None) , ( DNA: IL-2 gene, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-5, None) , ( DNA: IL-5 gene, None) , ( DNA: IL-2 gene, None) , ( protein: IL-2, None) " }

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{ "id": "1824", "sentence": "One of the nuclear factors ( NFs ) that regulates the response of the IL-5 promoter to cAMP and PMA has properties similar to NF for activated t cell .", "label": " ( cell type: activated t cell, None) , ( protein: IL-5, None) , ( DNA: IL-5 promoter, None) , ( protein: NFs, None) , ( protein: NF, None) , ( protein: nuclear factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: activated t cell, None) , ( protein: IL-5, None) , ( DNA: IL-5 promoter, None) , ( protein: NFs, None) , ( protein: NF, None) , ( protein: nuclear factors, None) " }

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{ "id": "1825", "sentence": "The P sequence of the IL-4 gene , defined as a responsive element for PMA and calcium ionophore ( A23187 ), shares sequence similarity with the NF kappa B and the NF-activated T cell binding sites .", "label": " ( DNA: P sequence, None) , ( DNA: IL-4 gene, None) , ( DNA: responsive element, None) , ( protein: IL-4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: P sequence, None) , ( DNA: IL-4 gene, None) , ( DNA: responsive element, None) , ( protein: IL-4, None) " }

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{ "id": "1826", "sentence": "We attempted to determine whether NF(P) , a nuclear factor specific for the P sequence , is related to NF-kappa B and nuclear factor for activated T cell ( NF-AT ).", "label": " ( DNA: P sequence, None) , ( protein: NF(P), None) , ( protein: NF-kappa B, None) , ( protein: nuclear factor for activated T cell, None) , ( protein: NF-AT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: P sequence, None) , ( protein: NF(P), None) , ( protein: NF-kappa B, None) , ( protein: nuclear factor for activated T cell, None) , ( protein: NF-AT, None) " }

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{ "id": "1827", "sentence": "In electromobility shift assays both NF-kappa B ( P65 or P65/P50 heterodimer ) and NF-AT bound to the P sequence .", "label": " ( protein: NF-kappa B, None) , ( protein: P65/P50 heterodimer, None) , ( protein: NF-AT, None) , ( DNA: P sequence, None) , ( protein: P65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: P65/P50 heterodimer, None) , ( protein: NF-AT, None) , ( DNA: P sequence, None) , ( protein: P65, None) " }

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{ "id": "1828", "sentence": "However, sequence specificity of NF-AT was more similar to that of NF(P) , and only a small amount of P65 was detected in NF(P) .", "label": " ( protein: NF-AT, None) , ( protein: NF(P), None) , ( protein: NF(P), None) , ( protein: P65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT, None) , ( protein: NF(P), None) , ( protein: NF(P), None) , ( protein: P65, None) " }

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{ "id": "1829", "sentence": "These results indicate that a component or components of NF-AT have the potential to reconstitute NF(P) , whereas NF-kappa B alone does not account for NF(P) in Jurkat crude extract .", "label": " ( protein: NF(P), None) , ( protein: NF(P), None) , ( protein: NF-kappa B, None) , ( protein: NF-AT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF(P), None) , ( protein: NF(P), None) , ( protein: NF-kappa B, None) , ( protein: NF-AT, None) " }

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{ "id": "1830", "sentence": "Taken together, these results suggest that NF-AT-like factors are involved in the regulation of IL-4 and IL-5 genes .", "label": " ( protein: NF-AT-like factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT-like factors, None) " }

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{ "id": "1831", "sentence": "Solution structure of a POU-specific homeodomain : 3D-NMR studies of human B-cell transcription factor Oct-2 .", "label": " ( protein: Oct-2, None) , ( protein: B-cell transcription factor, None) , ( protein: POU-specific homeodomain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-2, None) , ( protein: B-cell transcription factor, None) , ( protein: POU-specific homeodomain, None) " }

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{ "id": "1832", "sentence": "The POU DNA-binding motif defines a conserved family of eukaryotic transcription factors involved in regulation of gene expression .", "label": " ( protein: eukaryotic transcription factors, None) , ( protein: POU DNA-binding motif, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: eukaryotic transcription factors, None) , ( protein: POU DNA-binding motif, None) " }

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{ "id": "1833", "sentence": "This bipartite motif consists of an N-terminal POU-specific domain ( POUs ), a flexible linker , and a C-terminal POU-specific homeodomain ( POUHD ).", "label": " ( protein: POU-specific homeodomain, None) , ( protein: POUs, None) , ( protein: bipartite motif, None) , ( protein: POUHD, None) , ( protein: N-terminal POU-specific domain, None) , ( protein: C-terminal POU-specific homeodomain, None) , ( protein: flexible linker, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: POU-specific homeodomain, None) , ( protein: POUs, None) , ( protein: bipartite motif, None) , ( protein: POUHD, None) , ( protein: N-terminal POU-specific domain, None) , ( protein: C-terminal POU-specific homeodomain, None) , ( protein: flexible linker, None) " }

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{ "id": "1834", "sentence": "Here we describe the solution structure of a POU-specific homeodomain .", "label": " ( protein: POU-specific homeodomain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: POU-specific homeodomain, None) " }

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{ "id": "1835", "sentence": "An NMR model is obtained from Oct-2 , a human B-cell specific transcription factor which participates in the regulation of immunoglobulin genes .", "label": " ( protein: Oct-2, None) , ( protein: human B-cell specific transcription factor, None) , ( DNA: immunoglobulin genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-2, None) , ( protein: human B-cell specific transcription factor, None) , ( DNA: immunoglobulin genes, None) " }

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{ "id": "1836", "sentence": "A fragment of Oct-2 containing POUHD and an adjoining linker was expressed in Escherichia coli and characterized by three-dimensional nuclear magnetic resonance ( 3D-NMR ) spectroscopy .", "label": " ( protein: Oct-2, None) , ( protein: POUHD, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-2, None) , ( protein: POUHD, None) " }

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{ "id": "1837", "sentence": "Complete 1H and 15N resonance assignment of the POUHD moiety is presented.", "label": " ( protein: POUHD, None) , ( protein: POUHD moiety, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: POUHD, None) , ( protein: POUHD moiety, None) " }

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{ "id": "1838", "sentence": "The POUHD solution structure , as calculated by distance geometry and simulated annealing ( DG/SA ), is similar to that of canonical homeodomains .", "label": " ( protein: POUHD, None) , ( protein: canonical homeodomains, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: POUHD, None) , ( protein: canonical homeodomains, None) " }

[]

{ "id": "1839", "sentence": "A salient difference between solution and crystal structures is observed in the C-terminal segment of alpha-helix 3 (the HTH recognition helix ), which is not well ordered in solution.", "label": " ( protein: C-terminal segment, None) , ( protein: alpha-helix 3, None) , ( protein: HTH recognition helix, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: C-terminal segment, None) , ( protein: alpha-helix 3, None) , ( protein: HTH recognition helix, None) " }

[]

{ "id": "1840", "sentence": "Because this segment presumably folds upon specific DNA binding, its flexibility in solution may reduce the intrinsic DNA affinity of POUHD in the absence of POUs .", "label": " ( protein: POUHD, None) , ( protein: POUs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: POUHD, None) , ( protein: POUs, None) " }

[]

{ "id": "1841", "sentence": "NF-kappa B -dependent and -independent pathways of HIV activation in a chronically infected T cell line .", "label": " ( cell line: chronically infected T cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: chronically infected T cell line, None) " }

[]

{ "id": "1842", "sentence": "J delta K cells were isolated as a chronically infected survivor cell line , following infection of Jurkat CD4+ T cells with dl-NF , a mutated strain of human immunodeficiency virus type 1 ( HIV-1 ) containing a deletion of the long terminal repeat ( LTR ) NF-kappa B sites.", "label": " ( protein: NF-kappa B, None) , ( cell line: chronically infected survivor cell line, None) , ( DNA: long terminal repeat, None) , ( cell line: J delta K cells, None) , ( DNA: LTR, None) , ( cell line: Jurkat CD4+ T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( cell line: chronically infected survivor cell line, None) , ( DNA: long terminal repeat, None) , ( cell line: J delta K cells, None) , ( DNA: LTR, None) , ( cell line: Jurkat CD4+ T cells, None) " }

[]

{ "id": "1843", "sentence": "J delta K cells exhibited very low levels of constitutive HIV production .", "label": " ( cell line: J delta K cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: J delta K cells, None) " }

[]

{ "id": "1844", "sentence": "HIV-1 expression was activated from J delta K cells by treatment with phorbol myristate acetate ( PMA ), sodium butyrate ( NaB ), or hexamethylene bisacetamide ( HMBA ), but not tumor necrosis factor alpha ( TNF-alpha ), confirming the role of NF-kappa B in mediating TNF-alpha induction of HIV transcription .", "label": " ( protein: NF-kappa B, None) , ( protein: tumor necrosis factor alpha, None) , ( protein: TNF-alpha, None) , ( protein: TNF-alpha, None) , ( cell line: J delta K cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: tumor necrosis factor alpha, None) , ( protein: TNF-alpha, None) , ( protein: TNF-alpha, None) , ( cell line: J delta K cells, None) " }

[]

{ "id": "1845", "sentence": "The strong induction of HIV expression by NaB or HMBA in J delta K cells clearly demonstrates the existence of NF-kappa B -independent mechanisms of HIV activation in chronically infected cells .", "label": " ( cell line: J delta K cells, None) , ( protein: NF-kappa B, None) , ( cell type: chronically infected cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: J delta K cells, None) , ( protein: NF-kappa B, None) , ( cell type: chronically infected cells, None) " }

[]

{ "id": "1846", "sentence": "J delta K cells may provide a useful model for characterizing NF-kappa B -independent transcriptional activation of the HIV LTR .", "label": " ( cell line: J delta K cells, None) , ( DNA: HIV LTR, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: J delta K cells, None) , ( DNA: HIV LTR, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "1847", "sentence": "JNK is involved in signal integration during costimulation of T lymphocytes .", "label": " ( protein: JNK, None) , ( cell type: T lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: JNK, None) , ( cell type: T lymphocytes, None) " }

[]

{ "id": "1848", "sentence": "T lymphocyte activation and interleukin-2 ( IL-2 ) production require at least two signals, generated by phorbol ester ( TPA ) and Ca2+ ionophore or costimulation of the T cell receptor ( TCR ) and the CD28 auxiliary receptor .", "label": " ( protein: interleukin-2, None) , ( protein: TCR, None) , ( protein: CD28 auxiliary receptor, None) , ( protein: T cell receptor, None) , ( cell type: T lymphocyte, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin-2, None) , ( protein: TCR, None) , ( protein: CD28 auxiliary receptor, None) , ( protein: T cell receptor, None) , ( cell type: T lymphocyte, None) , ( protein: IL-2, None) " }

[]

{ "id": "1849", "sentence": "We investigated how these stimuli affect mitogen activated protein (MAP) kinases .", "label": " ( protein: mitogen activated protein (MAP) kinases, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: mitogen activated protein (MAP) kinases, None) " }

[]

{ "id": "1850", "sentence": "Full activation of the MAP kinases that phosphorylate the Jun activation domain , JNK1 and JNK2 , required costimulation of T cells with either TPA and Ca2+ ionophore or antibodies to TCR and CD28 .", "label": " ( protein: JNK1, None) , ( cell type: T cells, None) , ( protein: Jun activation domain, None) , ( protein: JNK2, None) , ( protein: MAP kinases, None) , ( protein: CD28, None) , ( protein: TCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: JNK1, None) , ( cell type: T cells, None) , ( protein: Jun activation domain, None) , ( protein: JNK2, None) , ( protein: MAP kinases, None) , ( protein: CD28, None) , ( protein: TCR, None) " }

[]

{ "id": "1851", "sentence": "Alone, each stimulus resulted in little or no activation.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1852", "sentence": "Similar to its effect on IL-2 induction , cyclosporin A ( CsA ) inhibited the synergistic activation of JNK , and a competitive inhibitor of Jun phosphorylation by JNK inhibited IL-2 promoter activation .", "label": " ( DNA: IL-2 promoter, None) , ( protein: Jun, None) , ( protein: JNK, None) , ( protein: IL-2, None) , ( protein: IL-2, None) , ( protein: JNK, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IL-2 promoter, None) , ( protein: Jun, None) , ( protein: JNK, None) , ( protein: IL-2, None) , ( protein: IL-2, None) , ( protein: JNK, None) " }

[]

{ "id": "1853", "sentence": "By contrast, the MAP kinases ERK1 and ERK2 were fully activated by TPA or TCR stimulation and were not affected by Ca2+ , CD28, or CsA .", "label": " ( protein: ERK1, None) , ( protein: ERK2, None) , ( protein: MAP kinases, None) , ( protein: TCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ERK1, None) , ( protein: ERK2, None) , ( protein: MAP kinases, None) , ( protein: TCR, None) " }

[]

{ "id": "1854", "sentence": "Hence, integration of signals that lead to T cell activation occurs at the level of JNK activation.", "label": " ( protein: JNK, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: JNK, None) " }

[]

{ "id": "1855", "sentence": "Inhibition of rat splenocyte proliferation with methylprednisolone : in vivo effect of liposomal formulation .", "label": " ( cell type: rat splenocyte, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: rat splenocyte, None) " }

[]

{ "id": "1856", "sentence": "The effect of a liposomal formulation of methylprednisolone ( MPL ) on the inhibition of lymphocyte proliferation in spleen cells was investigated following IV dosing in rats .", "label": " ( cell type: spleen cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: spleen cells, None) " }

[]

{ "id": "1857", "sentence": "Liposomes do not alter the suppressive action of MPL when placed in lymphocyte culture .", "label": " ( cell line: lymphocyte culture, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: lymphocyte culture, None) " }

[]

{ "id": "1858", "sentence": "Rat splenocytes were found to have greater sensitivity to MPL (EC50 = 7.9 nM) than do human peripheral blood lymphocytes (EC50 = 28 nM).", "label": " ( cell type: Rat splenocytes, None) , ( cell type: human peripheral blood lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: Rat splenocytes, None) , ( cell type: human peripheral blood lymphocytes, None) " }

[]

{ "id": "1859", "sentence": "In vivo studies in rats utilized 2 mg/kg IV bolus doses of liposomal MPL compared to drug in solution.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1860", "sentence": "Animals were sacrificed at various times post-dosing until 120 h, spleen was excised and, after incubation of lymphocytes with PHA , splenocyte blastogenic responses were assessed by measuring cellular incorporation of 3H-thymidine .", "label": " ( cell type: lymphocytes, None) , ( protein: PHA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphocytes, None) , ( protein: PHA, None) " }

[]

{ "id": "1861", "sentence": "The suppressive effect of liposomal MPL in comparison with free drug was significantly prolonged (> 120 h vs < 18 h).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1862", "sentence": "Inhibition effects versus time were described by a pharmacodynamic model using MPL concentrations in plasma as an input function.", "label": " ( cell type: plasma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: plasma, None) " }

[]

{ "id": "1863", "sentence": "A nonlinear relationship was found between suppression of splenocyte proliferation and the concentration of bound glucocorticoid receptors in spleen .", "label": " ( protein: glucocorticoid receptors, None) , ( cell type: splenocyte, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptors, None) , ( cell type: splenocyte, None) " }

[]

{ "id": "1864", "sentence": "Only partial receptor occupancy accompanied complete lymphocyte suppression .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1865", "sentence": "The suppression of endogenous corticosterone in plasma for both treatments was similar with values from L- MPL rats returning to baseline after 24 h.", "label": " ( cell type: plasma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: plasma, None) " }

[]

{ "id": "1866", "sentence": "These results demonstrate enhanced efficacy of local immunosuppression by targeting spleen with liposomal MPL .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1867", "sentence": "Function of NF-kappa B /Rel binding sites in the major histocompatibility complex class II invariant chain promoter is dependent on cell-specific binding of different NF-kappa B /Rel subunits .", "label": " ( protein: NF-kappa B /Rel subunits, None) , ( DNA: NF-kappa B /Rel binding sites, None) , ( DNA: major histocompatibility complex class II invariant chain promoter, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B /Rel subunits, None) , ( DNA: NF-kappa B /Rel binding sites, None) , ( DNA: major histocompatibility complex class II invariant chain promoter, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "1868", "sentence": "The promoter of the human major histocompatibility complex class II-associated invariant-chain gene ( Ii ) contains two NF-kappa B /Rel binding sites located at -109 to -118 ( Ii kappa B-1 ) and -163 to -172 ( Ii kappa B-2 ) from the transcription start site.", "label": " ( DNA: -163 to -172, None) , ( protein: NF-kappa B, None) , ( DNA: histocompatibility complex class II-associated invariant-chain gene, None) , ( DNA: -109 to -118, None) , ( DNA: Ii kappa B-1, None) , ( DNA: Ii, None) , ( DNA: NF-kappa B /Rel binding sites, None) , ( DNA: promoter, None) , ( DNA: Ii kappa B-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: -163 to -172, None) , ( protein: NF-kappa B, None) , ( DNA: histocompatibility complex class II-associated invariant-chain gene, None) , ( DNA: -109 to -118, None) , ( DNA: Ii kappa B-1, None) , ( DNA: Ii, None) , ( DNA: NF-kappa B /Rel binding sites, None) , ( DNA: promoter, None) , ( DNA: Ii kappa B-2, None) " }

[]

{ "id": "1869", "sentence": "We report here that the differential function of each of these NF-kappa B /Rel sites in several distinct cell types depends on cell-specific binding of NF-kappa B /Rel transcription factors .", "label": " ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B /Rel transcription factors, None) , ( DNA: NF-kappa B /Rel sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B /Rel transcription factors, None) , ( DNA: NF-kappa B /Rel sites, None) " }

[]

{ "id": "1870", "sentence": "Ii kappa B-1 is a positive regulatory element in B-cell lines and in the Ii-expressing T-cell line , H9 , but acts as a negative regulatory element in myelomonocytic and glia cell lines .", "label": " ( DNA: positive regulatory element, None) , ( cell line: H9, None) , ( DNA: Ii kappa B-1, None) , ( cell line: Ii-expressing T-cell line, None) , ( cell line: B-cell lines, None) , ( DNA: negative regulatory element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: positive regulatory element, None) , ( cell line: H9, None) , ( DNA: Ii kappa B-1, None) , ( cell line: Ii-expressing T-cell line, None) , ( cell line: B-cell lines, None) , ( DNA: negative regulatory element, None) " }

[]

{ "id": "1871", "sentence": "In vivo protein-DNA contacts are detectable at Ii kappa B-1 in cell lines in which this site is functional as either a positive or negative regulator .", "label": " ( cell line: cell lines, None) , ( DNA: Ii kappa B-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: cell lines, None) , ( DNA: Ii kappa B-1, None) " }

[]

{ "id": "1872", "sentence": "Electrophoretic mobility supershift assays determine that members of the NF-kappa B /Rel family of transcription factors can bind to this site in vitro and that DNA-binding complexes that contain p50 , p52 , p65 , and cRel correlate with positive regulation whereas the presence of p50 correlates with negative regulation .", "label": " ( protein: p50, None) , ( protein: p52, None) , ( protein: p50, None) , ( protein: cRel, None) , ( protein: NF-kappa B /Rel family, None) , ( protein: DNA-binding complexes, None) , ( protein: NF-kappa B, None) , ( protein: transcription factors, None) , ( protein: p65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p50, None) , ( protein: p52, None) , ( protein: p50, None) , ( protein: cRel, None) , ( protein: NF-kappa B /Rel family, None) , ( protein: DNA-binding complexes, None) , ( protein: NF-kappa B, None) , ( protein: transcription factors, None) , ( protein: p65, None) " }

[]

{ "id": "1873", "sentence": "Ii kappa B-2 is a site of positive regulation in B-cell lines and a site of negative regulation in H9 T cells , myelomonocytic , and glial cell lines .", "label": " ( DNA: Ii kappa B-2, None) , ( cell line: B-cell lines, None) , ( cell line: H9 T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Ii kappa B-2, None) , ( cell line: B-cell lines, None) , ( cell line: H9 T cells, None) " }

[]

{ "id": "1874", "sentence": "In vivo occupancy of this site is observed only in the H9 T-cell line .", "label": " ( cell line: H9 T-cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: H9 T-cell line, None) " }

[]

{ "id": "1875", "sentence": "Again, in vitro supershift studies indicate that the presence of p50 , p52 , p65 , and cRel correlates with positive function whereas the presence of only p50 and p52 correlates with negative function .", "label": " ( protein: p50, None) , ( protein: p65, None) , ( protein: p52, None) , ( protein: p52, None) , ( protein: cRel, None) , ( protein: p50, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p50, None) , ( protein: p65, None) , ( protein: p52, None) , ( protein: p52, None) , ( protein: cRel, None) , ( protein: p50, None) " }

[]

{ "id": "1876", "sentence": "This differential binding of specific NF-kappa B /Rel subunits is likely to mediate the disparate functions of these two NF-kappa B /Rel binding sites .", "label": " ( protein: NF-kappa B, None) , ( DNA: NF-kappa B /Rel binding sites, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B /Rel subunits, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( DNA: NF-kappa B /Rel binding sites, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B /Rel subunits, None) " }

[]

{ "id": "1877", "sentence": "Epstein-Barr virus ( EBV ) replicative gene expression in tumour cells of AIDS-related non-Hodgkin's lymphoma in relation to CD4 cell number and antibody titres to EBV .", "label": " ( cell type: tumour cells, None) , ( protein: CD4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: tumour cells, None) , ( protein: CD4, None) " }

[]

{ "id": "1878", "sentence": "OBJECTIVE: To determine whether activation of Epstein-Barr virus ( EBV ) replication in tumour cells of AIDS-related non-Hodgkin's lymphoma ( ARNHL ) is correlated with CD4+ cell counts and influences antibody response to EBV [ anti-Z Epstein-Barr replicative activator ( ZEBRA ), anti-early antigen ( EA ), anti-viral capsid antigen ( VCA )].", "label": " ( protein: anti-early antigen, None) , ( protein: CD4+, None) , ( cell type: tumour cells, None) , ( protein: anti-Z Epstein-Barr replicative activator, None) , ( protein: ZEBRA, None) , ( protein: anti-viral capsid antigen, None) , ( protein: VCA, None) , ( protein: EA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti-early antigen, None) , ( protein: CD4+, None) , ( cell type: tumour cells, None) , ( protein: anti-Z Epstein-Barr replicative activator, None) , ( protein: ZEBRA, None) , ( protein: anti-viral capsid antigen, None) , ( protein: VCA, None) , ( protein: EA, None) " }

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{ "id": "1879", "sentence": "DESIGN: Retrospective study based on immunohistochemistry and in situ hybridization to detect EBV replicative gene products in tissue samples from patients affected by ARNHL and correlation with CD4+ cell counts and results of EBV serology (including anti- ZEBRA activity ) in sera from the same patients .", "label": " ( protein: ZEBRA, None) , ( protein: CD4+, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ZEBRA, None) , ( protein: CD4+, None) " }

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{ "id": "1880", "sentence": "METHODS: Seventeen out of 22 cases of ARNHL were selected for the presence of EBV [ Epstein-Barr early region (EBER) RNA-positive ].", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1881", "sentence": "Immunohistochemistry was performed with anti- ZEBRA , anti- EA -restricted, anti- VCA antibodies and in situ hybridization with BHLF1/NotI oligoprobes on tumour samples .", "label": " ( protein: VCA, None) , ( protein: anti- ZEBRA, None) , ( protein: ZEBRA, None) , ( protein: EA, None) , ( protein: anti- EA -restricted, anti- VCA antibodies, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: VCA, None) , ( protein: anti- ZEBRA, None) , ( protein: ZEBRA, None) , ( protein: EA, None) , ( protein: anti- EA -restricted, anti- VCA antibodies, None) " }

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{ "id": "1882", "sentence": "Results were statistically correlated with those of CD4+ cell counts (17 out of 17) and with anti- EBV antibody titres (13 out of 17) assessed using standard immunofluorescence method and enzyme-linked immunosorbent assay procedure using recombinant ZEBRA protein and synthetic peptides as antigens .", "label": " ( protein: recombinant ZEBRA protein, None) , ( protein: CD4+, None) , ( protein: antigens, None) , ( protein: ZEBRA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: recombinant ZEBRA protein, None) , ( protein: CD4+, None) , ( protein: antigens, None) , ( protein: ZEBRA, None) " }

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{ "id": "1883", "sentence": "RESULTS: BZLF1 ( ZEBRA ) or early gene products ( EA-R and EA-D/BHLF1/NotI ) were detected in a small proportion (< 0.01-5%) of tumour cells in eight of these 17 cases by immunohistochemistry and in situ hybridization .", "label": " ( protein: BZLF1, None) , ( protein: EA-D/BHLF1/NotI, None) , ( protein: EA-R, None) , ( cell type: tumour cells, None) , ( protein: ZEBRA, None) , ( protein: early gene products, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: BZLF1, None) , ( protein: EA-D/BHLF1/NotI, None) , ( protein: EA-R, None) , ( cell type: tumour cells, None) , ( protein: ZEBRA, None) , ( protein: early gene products, None) " }

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{ "id": "1884", "sentence": "Demonstration of replicative gene expression did not correlate with either low CD4+ cell counts (P > 0.05) or anti- EBV antibody titres (P > 0.05).", "label": " ( protein: CD4+, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD4+, None) " }

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{ "id": "1885", "sentence": "Anti- ZEBRA activity was not significantly increased in patients affected with ARNHL , the cells of which expressed replicative gene products (P > 0.05).", "label": " ( protein: ZEBRA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ZEBRA, None) " }

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{ "id": "1886", "sentence": "CONCLUSION: The degree of immunodeficiency does not clearly enhance replicative gene expression in tumour cells of ARNHL .", "label": " ( cell type: tumour cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: tumour cells, None) " }

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{ "id": "1887", "sentence": "EBV serology , including anti- ZEBRA activity , is not a reliable tool for predicting the occurrence of such proliferations.", "label": " ( protein: ZEBRA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ZEBRA, None) " }

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{ "id": "1888", "sentence": "Effects of prostaglandin E2 on Th0-type human T cell clones : modulation of functions of nuclear proteins involved in cytokine production .", "label": " ( cell line: Th0-type human T cell clones, None) , ( protein: cytokine, None) , ( protein: prostaglandin E2, None) , ( protein: nuclear proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Th0-type human T cell clones, None) , ( protein: cytokine, None) , ( protein: prostaglandin E2, None) , ( protein: nuclear proteins, None) " }

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{ "id": "1889", "sentence": "The effects of prostaglandin E2 ( PGE2 ) on cytokine production and proliferation of the CD4+ human helper T cell clone SP-B21 were investigated.", "label": " ( cell line: CD4+ human helper T cell clone SP-B21, None) , ( protein: prostaglandin E2, None) , ( protein: cytokine, None) , ( protein: PGE2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: CD4+ human helper T cell clone SP-B21, None) , ( protein: prostaglandin E2, None) , ( protein: cytokine, None) , ( protein: PGE2, None) " }

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{ "id": "1890", "sentence": "In cells stimulated with anti-CD3 mAb , PGE2 inhibited cell proliferation and the production of all the cytokines examined.", "label": " ( protein: PGE2, None) , ( protein: cytokines, None) , ( protein: anti-CD3 mAb, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PGE2, None) , ( protein: cytokines, None) , ( protein: anti-CD3 mAb, None) " }

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{ "id": "1891", "sentence": "Addition of rIL-2 fully restored the proliferative response and partially restored the production of IL-4 and IL-5 , but not that of other cytokines .", "label": " ( protein: rIL-2, None) , ( protein: IL-4, None) , ( protein: cytokines, None) , ( protein: IL-5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: rIL-2, None) , ( protein: IL-4, None) , ( protein: cytokines, None) , ( protein: IL-5, None) " }

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{ "id": "1892", "sentence": "In contrast, in cells stimulated with phorbol myristate acetate ( PMA )/ A23187 , PGE2 enhanced the production of IL-4 and IL-5 , and only partially inhibited the production of other cytokines .", "label": " ( protein: IL-4, None) , ( protein: cytokines, None) , ( protein: IL-5, None) , ( protein: PGE2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-4, None) , ( protein: cytokines, None) , ( protein: IL-5, None) , ( protein: PGE2, None) " }

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{ "id": "1893", "sentence": "Therefore, the effects of PGE2 vary depending on the mode of T cell activation , and the IL-4 and IL-5 are regulated differently from other cytokines .", "label": " ( protein: IL-4, None) , ( protein: IL-5, None) , ( protein: PGE2, None) , ( protein: cytokines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-4, None) , ( protein: IL-5, None) , ( protein: PGE2, None) , ( protein: cytokines, None) " }

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{ "id": "1894", "sentence": "In a mobility shift assay , only the NF-kappa B ( p50 /p50 ) homodimer was observed in a complex formed with the kappa B sequence in unstimulated SP-B21 cells.", "label": " ( protein: NF-kappa B, None) , ( protein: p50, None) , ( DNA: kappa B sequence, None) , ( protein: NF-kappa B ( p50 /p50 ) homodimer, None) , ( protein: /p50, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: p50, None) , ( DNA: kappa B sequence, None) , ( protein: NF-kappa B ( p50 /p50 ) homodimer, None) , ( protein: /p50, None) " }

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{ "id": "1895", "sentence": "When cells were stimulated with anti-CD3 mAb or PMA /A23187 , a complex formation of NF-kappa B ( p50 /p65 ) heterodimer with the kappa B sequence was induced.", "label": " ( protein: p50, None) , ( DNA: kappa B sequence, None) , ( protein: /p65, None) , ( protein: NF-kappa B, None) , ( protein: anti-CD3 mAb, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p50, None) , ( DNA: kappa B sequence, None) , ( protein: /p65, None) , ( protein: NF-kappa B, None) , ( protein: anti-CD3 mAb, None) " }

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{ "id": "1896", "sentence": "Interestingly, PGE2 or di-butyryl (Bt2) cAMP abolished the binding of NF-kappa B ( p50 /p65 ) heterodimer to the kappa B sequence in cells stimulated with anti-CD3 mAb but not with PMA /A23187 .", "label": " ( protein: /p65, None) , ( protein: p50, None) , ( protein: NF-kappa B ( p50 /p65 ) heterodimer, None) , ( protein: NF-kappa B, None) , ( DNA: kappa B sequence, None) , ( protein: anti-CD3 mAb, None) , ( protein: PGE2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: /p65, None) , ( protein: p50, None) , ( protein: NF-kappa B ( p50 /p65 ) heterodimer, None) , ( protein: NF-kappa B, None) , ( DNA: kappa B sequence, None) , ( protein: anti-CD3 mAb, None) , ( protein: PGE2, None) " }

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{ "id": "1897", "sentence": "Our results suggest that the target of PGE2 action is a component in the signal transduction pathway leading to the activation of protein kinase C .", "label": " ( protein: protein kinase C, None) , ( protein: PGE2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: protein kinase C, None) , ( protein: PGE2, None) " }

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{ "id": "1898", "sentence": "However, the inhibition of the T cell activation signals by PGE2 is selective.", "label": " ( protein: PGE2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PGE2, None) " }

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{ "id": "1899", "sentence": "PGE2 enhanced the complex formation with NF-AT , AP-1 and CLE0 sequences when the cells were activated by either anti-CD3 mAb or PMA /A23187 stimulation .", "label": " ( protein: PGE2, None) , ( protein: anti-CD3 mAb, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PGE2, None) , ( protein: anti-CD3 mAb, None) " }