Datasets:

huy-nh-2000

/

instructUIE

like 0

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{ "id": "2100", "sentence": "Induction of HIV-1 - LTR -driven transcription in THP-1 cells by superantigens was associated with the induction of nuclear factor-kappa B DNA-binding activity .", "label": " ( DNA: LTR, None) , ( protein: superantigens, None) , ( protein: nuclear factor-kappa B, None) , ( cell line: THP-1 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LTR, None) , ( protein: superantigens, None) , ( protein: nuclear factor-kappa B, None) , ( cell line: THP-1 cells, None) " }

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{ "id": "2101", "sentence": "Superantigens also increased viral protein secretion from the granulocyte-macrophage colony-stimulating factor -pretreated chronically infected human monocytic cell line U1 .", "label": " ( cell line: granulocyte-macrophage colony-stimulating factor -pretreated chronically infected human monocytic cell line U1, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( protein: Superantigens, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: granulocyte-macrophage colony-stimulating factor -pretreated chronically infected human monocytic cell line U1, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( protein: Superantigens, None) " }

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{ "id": "2102", "sentence": "Induction of HIV-1 gene expression in monocytic cells by superantigens occurred via tumor necrosis factor-alpha -dependent and -independent mechanisms .", "label": " ( cell type: monocytic cells, None) , ( protein: superantigens, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytic cells, None) , ( protein: superantigens, None) " }

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{ "id": "2103", "sentence": "Our results suggest that superantigens and other MHC class II ligands may activate HIV-1 gene expression in monocytes/macrophages .", "label": " ( cell type: monocytes/macrophages, None) , ( protein: MHC class II ligands, None) , ( protein: superantigens, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytes/macrophages, None) , ( protein: MHC class II ligands, None) , ( protein: superantigens, None) " }

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{ "id": "2104", "sentence": "Mitogen activation of human peripheral T lymphocytes induces the formation of new cyclic AMP response element-binding protein nuclear complexes .", "label": " ( cell type: T lymphocytes, None) , ( cell type: human peripheral T lymphocytes, None) , ( protein: cyclic AMP response element-binding protein nuclear complexes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T lymphocytes, None) , ( cell type: human peripheral T lymphocytes, None) , ( protein: cyclic AMP response element-binding protein nuclear complexes, None) " }

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{ "id": "2105", "sentence": "A large body of evidence indicates that experimental agents which raise cellular cAMP levels inhibit T cell growth and division.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2106", "sentence": "By contrast, many studies have reported that mitogen activation of T cells increases cAMP levels, implying a positive physiological role for cAMP in the activation process.", "label": " ( cell type: T cells, None) , ( protein: mitogen, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: mitogen, None) " }

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{ "id": "2107", "sentence": "In the present study we demonstrate that mitogen activation of human peripheral T lymphocytes induces nuclear factors that form complexes with cyclic AMP response element-binding protein ( CREB ).", "label": " ( cell type: T lymphocytes, None) , ( cell type: human peripheral T lymphocytes, None) , ( protein: CREB, None) , ( protein: mitogen, None) , ( protein: cyclic AMP response element-binding protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T lymphocytes, None) , ( cell type: human peripheral T lymphocytes, None) , ( protein: CREB, None) , ( protein: mitogen, None) , ( protein: cyclic AMP response element-binding protein, None) " }

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{ "id": "2108", "sentence": "Four complexes are identified by the electrophoretic mobility shift assay , two of which are induced by mitogen activation .", "label": " ( protein: mitogen, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: mitogen, None) " }

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{ "id": "2109", "sentence": "All four complexes contain CREB and are bound to the cAMP response element ( CRE ) core sequence ( TGACGTCA ), as indicated by antibody and oligonucleotide competition experiments .", "label": " ( protein: CREB, None) , ( DNA: CRE, None) , ( DNA: cAMP response element, None) , ( DNA: cAMP response element ( CRE ) core sequence, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CREB, None) , ( DNA: CRE, None) , ( DNA: cAMP response element, None) , ( DNA: cAMP response element ( CRE ) core sequence, None) " }

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{ "id": "2110", "sentence": "Binding of the four complexes to CRE is prevented by dephosphorylation of nuclear extracts and is restored by rephosphorylation with cAMP -dependent protein kinase or endogenous kinases .", "label": " ( protein: endogenous kinases, None) , ( DNA: CRE, None) , ( protein: cAMP -dependent protein kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: endogenous kinases, None) , ( DNA: CRE, None) , ( protein: cAMP -dependent protein kinase, None) " }

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{ "id": "2111", "sentence": "Similar complexes are detected in nuclear extracts of Jurkat cells .", "label": " ( cell line: Jurkat cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Jurkat cells, None) " }

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{ "id": "2112", "sentence": "Mitogen induction of the electrophoretic mobility shift assay complexes is not accounted for by protein phosphorylation or by induction of CREB .", "label": " ( protein: CREB, None) , ( protein: electrophoretic mobility shift assay complexes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CREB, None) , ( protein: electrophoretic mobility shift assay complexes, None) " }

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{ "id": "2113", "sentence": "Rather, the data indicate that mitogen increases the levels of a nuclear factor(s) that dimerizes with CREB .", "label": " ( protein: CREB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CREB, None) " }

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{ "id": "2114", "sentence": "Induction of new CREB complexes implies a physiological role for cAMP in mitogen activation of T lymphocytes .", "label": " ( protein: CREB complexes, None) , ( protein: mitogen, None) , ( protein: CREB, None) , ( cell type: T lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CREB complexes, None) , ( protein: mitogen, None) , ( protein: CREB, None) , ( cell type: T lymphocytes, None) " }

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{ "id": "2115", "sentence": "Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells .", "label": " ( cell line: cultured human endothelial cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: cultured human endothelial cells, None) " }

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{ "id": "2116", "sentence": "Antioxidants have been proposed to be anti-atherosclerotic agents ; however, the mechanisms underlying their beneficial effects are poorly understood.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2117", "sentence": "We have examined the effect of alpha-tocopherol ( alpha-tcp ) on one cellular event in atherosclerotic plaque development , monocyte adhesion to stimulated endothelial cells ( ECs ).", "label": " ( cell type: stimulated endothelial cells, None) , ( cell type: ECs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: stimulated endothelial cells, None) , ( cell type: ECs, None) " }

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{ "id": "2118", "sentence": "Human umbilical vein ECs were pretreated with alpha-tcp before stimulation with known agonists of monocyte adhesion : IL-1 (10 ng/ml), LPS (10 ng/ml), thrombin (30 U/ml), or PMA (10 nM).", "label": " ( protein: IL-1, None) , ( cell type: ECs, None) , ( protein: thrombin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-1, None) , ( cell type: ECs, None) , ( protein: thrombin, None) " }

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{ "id": "2119", "sentence": "Agonist-induced monocytic cell adhesion , but not basal adhesion , was inhibited in a time- and concentration-dependent manner by alpha-tcp .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2120", "sentence": "The IC50 of alpha-tcp on an IL-1 -induced response was 45 microM.", "label": " ( protein: IL-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-1, None) " }

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{ "id": "2121", "sentence": "The inhibition correlated with a decrease in steady state levels of E-selectin mRNA and cell surface expression of E-selectin which is consistent with the ability of a monoclonal antibody to E-selectin to inhibit monocytic cell adhesion in this system.", "label": " ( RNA: E-selectin mRNA, None) , ( protein: E-selectin, None) , ( protein: monoclonal antibody, None) , ( protein: E-selectin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: E-selectin mRNA, None) , ( protein: E-selectin, None) , ( protein: monoclonal antibody, None) , ( protein: E-selectin, None) " }

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{ "id": "2122", "sentence": "Probucol (50 microM) and N-acetylcysteine (20 mM) also inhibited agonist-induced monocytic cell adhesion ; whereas, several other antioxidants had no significant effect.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2123", "sentence": "Protein kinase C ( PKC ) does not appear to play a role in the alpha-tcp effect since no suppression of phosphorylation of PKC substrates was observed.", "label": " ( protein: PKC, None) , ( protein: PKC, None) , ( protein: Protein kinase C, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC, None) , ( protein: PKC, None) , ( protein: Protein kinase C, None) " }

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{ "id": "2124", "sentence": "Activation of the transcription factor NF-kappa B is reported to be necessary but not sufficient for E-selectin expression in EC .", "label": " ( protein: transcription factor, None) , ( cell line: EC, None) , ( protein: E-selectin, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor, None) , ( cell line: EC, None) , ( protein: E-selectin, None) , ( protein: NF-kappa B, None) " }

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{ "id": "2125", "sentence": "Electrophoretic mobility shift assays failed to show an alpha-tcp -induced decrease in activation of this transcription factor after cytokine stimulation .", "label": " ( protein: cytokine, None) , ( protein: transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine, None) , ( protein: transcription factor, None) " }

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{ "id": "2126", "sentence": "It has been hypothesized that alpha-tcp acts as an anti-atherosclerotic molecule by inhibiting generation of oxidized LDL --a putative triggering molecule in the atherosclerotic process .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2127", "sentence": "Our results point to a novel alternative mechanism of action of alpha-tcp .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2128", "sentence": "Central nervous system -derived cells express a kappa B-binding activity that enhances human immunodeficiency virus type 1 transcription in vitro and facilitates TAR -independent transactivation by Tat .", "label": " ( cell type: Central nervous system -derived cells, None) , ( protein: Tat, None) , ( DNA: TAR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: Central nervous system -derived cells, None) , ( protein: Tat, None) , ( DNA: TAR, None) " }

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{ "id": "2129", "sentence": "The Tat protein of human immunodeficiency virus type 1 ( HIV-1 ) is a potent activator of long terminal repeat -directed transcription .", "label": " ( protein: Tat protein, None) , ( DNA: long terminal repeat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tat protein, None) , ( DNA: long terminal repeat, None) " }

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{ "id": "2130", "sentence": "While in most cell types, activation requires interaction of Tat with the unusual transcription element TAR , astrocytic glial cells support TAR -independent transactivation of HIV-1 transcription by Tat.", "label": " ( DNA: transcription element, None) , ( cell type: astrocytic glial cells, None) , ( DNA: TAR, None) , ( DNA: TAR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: transcription element, None) , ( cell type: astrocytic glial cells, None) , ( DNA: TAR, None) , ( DNA: TAR, None) " }

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{ "id": "2131", "sentence": "This alternative pathway of Tat activation is mediated by the viral enhancer , a kappa B domain capable of binding the prototypical form of the transcription factor nuclear factor kappa B ( NF-kappa B ) present in many cell types, including T lymphocytes .", "label": " ( protein: Tat, None) , ( protein: NF-kappa B, None) , ( protein: transcription factor, None) , ( DNA: viral enhancer, None) , ( cell type: T lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tat, None) , ( protein: NF-kappa B, None) , ( protein: transcription factor, None) , ( DNA: viral enhancer, None) , ( cell type: T lymphocytes, None) " }

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{ "id": "2132", "sentence": "Tat transactivation mediated by the kappa B domain is sufficient to allow replication of TAR -deleted mutant HIV-1 in astrocytes .", "label": " ( DNA: kappa B domain, None) , ( protein: Tat, None) , ( cell type: astrocytes, None) , ( DNA: TAR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: kappa B domain, None) , ( protein: Tat, None) , ( cell type: astrocytes, None) , ( DNA: TAR, None) " }

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{ "id": "2133", "sentence": "The present study demonstrates the existence of kappa B-specific binding factors present in human glial astrocytes that differ from prototypical NF-kappa B .", "label": " ( cell type: human glial astrocytes, None) , ( protein: kappa B-specific binding factors, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human glial astrocytes, None) , ( protein: kappa B-specific binding factors, None) , ( protein: NF-kappa B, None) " }

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{ "id": "2134", "sentence": "The novel astrocyte-derived kappa B-binding activity is retained on an HIV-1 Tat affinity column , while prototypical NF-kappa B from Jurkat T cells is not.", "label": " ( protein: Tat, None) , ( protein: NF-kappa B, None) , ( cell line: Jurkat T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tat, None) , ( protein: NF-kappa B, None) , ( cell line: Jurkat T cells, None) " }

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{ "id": "2135", "sentence": "In vitro transcription studies demonstrate that astrocyte-derived kappa B-binding factors activate transcription of the HIV-1 long terminal repeat and that this activation is dependent on the kappa B domain .", "label": " ( protein: astrocyte-derived kappa B-binding factors, None) , ( DNA: kappa B domain, None) , ( DNA: HIV-1 long terminal repeat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: astrocyte-derived kappa B-binding factors, None) , ( DNA: kappa B domain, None) , ( DNA: HIV-1 long terminal repeat, None) " }

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{ "id": "2136", "sentence": "Moreover, TAR -independent transactivation of HIV-1 transcription is reproduced in vitro in an astrocyte factor-dependent manner which correlates with kappa B-binding activity .", "label": " ( DNA: TAR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: TAR, None) " }

[]

{ "id": "2137", "sentence": "The importance of the central nervous system -enriched kappa B transcription factor in the regulation of HIV-1 expression is discussed.", "label": " ( protein: central nervous system -enriched kappa B, None) , ( protein: transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: central nervous system -enriched kappa B, None) , ( protein: transcription factor, None) " }

[]

{ "id": "2138", "sentence": "Human interleukin-13 activates the interleukin-4-dependent transcription factor NF-IL4 sharing a DNA binding motif with an interferon-gamma-induced nuclear binding factor .", "label": " ( protein: Human interleukin-13, None) , ( protein: interleukin-4-dependent transcription factor, None) , ( protein: transcription factor, None) , ( protein: DNA binding motif, None) , ( protein: NF-IL4, None) , ( protein: interferon-gamma-induced nuclear binding factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Human interleukin-13, None) , ( protein: interleukin-4-dependent transcription factor, None) , ( protein: transcription factor, None) , ( protein: DNA binding motif, None) , ( protein: NF-IL4, None) , ( protein: interferon-gamma-induced nuclear binding factor, None) " }

[]

{ "id": "2139", "sentence": "The effects of interleukin-13 ( IL-13 ) and interleukin-4 ( IL-4 ) on cellular functions were shown to be quite similar.", "label": " ( protein: interleukin-4, None) , ( protein: IL-13, None) , ( protein: IL-4, None) , ( protein: interleukin-13, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin-4, None) , ( protein: IL-13, None) , ( protein: IL-4, None) , ( protein: interleukin-13, None) " }

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{ "id": "2140", "sentence": "We provide evidence that in monocytes as well as in T lymphocytes both IL-4 and IL-13 activate the same recently identified transcription factor NF-IL4 which binds to the specific responsive element IL-4RE .", "label": " ( protein: NF-IL4, None) , ( protein: IL-4, None) , ( protein: IL-13, None) , ( protein: transcription factor, None) , ( cell type: T lymphocytes, None) , ( DNA: specific responsive element IL-4RE, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-IL4, None) , ( protein: IL-4, None) , ( protein: IL-13, None) , ( protein: transcription factor, None) , ( cell type: T lymphocytes, None) , ( DNA: specific responsive element IL-4RE, None) " }

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{ "id": "2141", "sentence": "In addition, we show that a nuclear factor activated by interferon-gamma also interacts with the IL-4RE .", "label": " ( protein: nuclear factor, None) , ( DNA: IL-4RE, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor, None) , ( DNA: IL-4RE, None) " }

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{ "id": "2142", "sentence": "It differs from NF-IL4 in the electrophoretic mobility of the complex with DNA, in its DNA-binding specificity and in the proteins interacting with the DNA sequence .", "label": " ( DNA: DNA sequence, None) , ( protein: NF-IL4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: DNA sequence, None) , ( protein: NF-IL4, None) " }

[]

{ "id": "2143", "sentence": "Sensitivity against various enzyme inhibitors suggests that components of the signal transduction pathway are shared by all three cytokines .", "label": " ( protein: cytokines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokines, None) " }

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{ "id": "2144", "sentence": "Encephalomyocarditis virus internal ribosomal entry site RNA-protein interactions .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2145", "sentence": "Translational initiation of encephalomyocarditis virus ( EMCV ) mRNA occurs by ribosomal entry into the 5' nontranslated region of the EMCV mRNA , rather than by ribosomal scanning .", "label": " ( DNA: 5#$%# nontranslated region, None) , ( RNA: encephalomyocarditis virus ( EMCV ) mRNA, None) , ( RNA: EMCV mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: 5#$%# nontranslated region, None) , ( RNA: encephalomyocarditis virus ( EMCV ) mRNA, None) , ( RNA: EMCV mRNA, None) " }

[]

{ "id": "2146", "sentence": "Internal ribosomal binding requires a cis-acting element termed the internal ribosomal entry site ( IRES ).", "label": " ( DNA: IRES, None) , ( DNA: cis-acting element, None) , ( DNA: internal ribosomal entry site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IRES, None) , ( DNA: cis-acting element, None) , ( DNA: internal ribosomal entry site, None) " }

[]

{ "id": "2147", "sentence": "IRES elements have been proposed to be involved in the translation of picornavirus mRNAs and some cellular mRNAs .", "label": " ( DNA: IRES elements, None) , ( RNA: cellular mRNAs, None) , ( RNA: picornavirus mRNAs, None) , ( DNA: IRES, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IRES elements, None) , ( RNA: cellular mRNAs, None) , ( RNA: picornavirus mRNAs, None) , ( DNA: IRES, None) " }

[]

{ "id": "2148", "sentence": "Internal ribosome binding likely requires the interaction of trans-acting factors that recognize both the mRNA and the ribosomal complex .", "label": " ( protein: trans-acting factors, None) , ( protein: ribosomal complex, None) , ( RNA: mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: trans-acting factors, None) , ( protein: ribosomal complex, None) , ( RNA: mRNA, None) " }

[]

{ "id": "2149", "sentence": "Five cellular proteins ( p52 , p57 , p70 , p72 , and p100 ) cross-link the EMCV IRES or fragments of the IRES .", "label": " ( DNA: IRES, None) , ( protein: cellular proteins, None) , ( protein: p72, None) , ( protein: p70, None) , ( protein: p57, None) , ( protein: p100, None) , ( protein: p52, None) , ( DNA: IRES, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IRES, None) , ( protein: cellular proteins, None) , ( protein: p72, None) , ( protein: p70, None) , ( protein: p57, None) , ( protein: p100, None) , ( protein: p52, None) , ( DNA: IRES, None) " }

[]

{ "id": "2150", "sentence": "For one of these proteins, p57 , binding to the IRES correlates with translation.", "label": " ( DNA: IRES, None) , ( protein: p57, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IRES, None) , ( protein: p57, None) " }

[]

{ "id": "2151", "sentence": "Recently, p57 was identified to be very similar, if not identical, to polypyrimidine tract-binding protein .", "label": " ( protein: p57, None) , ( protein: polypyrimidine tract-binding protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p57, None) , ( protein: polypyrimidine tract-binding protein, None) " }

[]

{ "id": "2152", "sentence": "On the basis of cross-linking results with 21 different EMCV IRES fragments and cytoplasmic HeLa extract or rabbit reticulocyte lysate as the source of polypeptides , consensus binding sites for p52 , p57 , p70 , and p100 are proposed.", "label": " ( DNA: EMCV IRES fragments, None) , ( protein: p52, None) , ( protein: p57, None) , ( protein: p100, None) , ( DNA: consensus binding sites, None) , ( DNA: IRES, None) , ( protein: p70, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: EMCV IRES fragments, None) , ( protein: p52, None) , ( protein: p57, None) , ( protein: p100, None) , ( DNA: consensus binding sites, None) , ( DNA: IRES, None) , ( protein: p70, None) " }

[]

{ "id": "2153", "sentence": "It is suggested that each of these proteins recognizes primarily a structural feature of the RNA rather than a specific sequence.", "label": " ( RNA: RNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: RNA, None) " }

[]

{ "id": "2154", "sentence": "A novel heterodimerization partner for thyroid hormone receptor .", "label": " ( protein: thyroid hormone receptor, None) , ( protein: heterodimerization partner, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: thyroid hormone receptor, None) , ( protein: heterodimerization partner, None) " }

[]

{ "id": "2155", "sentence": "Peroxisome proliferator-activated receptor .", "label": " ( protein: Peroxisome proliferator-activated receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Peroxisome proliferator-activated receptor, None) " }

[]

{ "id": "2156", "sentence": "Retinoid-like receptors play a central role in hormonal responses by forming heterodimers with other nuclear hormone receptors .", "label": " ( protein: nuclear hormone receptors, None) , ( protein: Retinoid-like receptors, None) , ( protein: heterodimers, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear hormone receptors, None) , ( protein: Retinoid-like receptors, None) , ( protein: heterodimers, None) " }

[]

{ "id": "2157", "sentence": "In this study we have identified the peroxisome proliferator-activated receptor ( PPAR ) as a new thyroid hormone receptor ( THR ) auxiliary nuclear protein , heterodimerizing with THR in solution.", "label": " ( protein: THR, None) , ( protein: peroxisome proliferator-activated receptor, None) , ( protein: thyroid hormone receptor, None) , ( protein: THR, None) , ( protein: thyroid hormone receptor ( THR ) auxiliary nuclear protein, None) , ( protein: PPAR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: THR, None) , ( protein: peroxisome proliferator-activated receptor, None) , ( protein: thyroid hormone receptor, None) , ( protein: THR, None) , ( protein: thyroid hormone receptor ( THR ) auxiliary nuclear protein, None) , ( protein: PPAR, None) " }

[]

{ "id": "2158", "sentence": "Although these heterodimers do not recognize a classical thyroid hormone response element ( TRE ) characterized by direct repeat separated by four nucleotides ( DR+4 ), PPAR behaves as a dominant negative regulator of thyroid hormone ( TH ) action .", "label": " ( DNA: thyroid hormone response element, None) , ( DNA: TRE, None) , ( protein: heterodimers, None) , ( protein: PPAR, None) , ( DNA: DR+4, None) , ( DNA: direct repeat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: thyroid hormone response element, None) , ( DNA: TRE, None) , ( protein: heterodimers, None) , ( protein: PPAR, None) , ( DNA: DR+4, None) , ( DNA: direct repeat, None) " }

[]

{ "id": "2159", "sentence": "However, a TH -dependent positive effect is elicited by selective interaction of the THR beta- PPAR but not the THR alpha- PPAR heterodimer with a novel TRE ( DR+2 ).", "label": " ( protein: THR, None) , ( protein: PPAR, None) , ( protein: THR, None) , ( DNA: DR+2, None) , ( protein: PPAR, None) , ( DNA: TRE, None) , ( protein: THR beta- PPAR, None) , ( protein: THR alpha- PPAR heterodimer, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: THR, None) , ( protein: PPAR, None) , ( protein: THR, None) , ( DNA: DR+2, None) , ( protein: PPAR, None) , ( DNA: TRE, None) , ( protein: THR beta- PPAR, None) , ( protein: THR alpha- PPAR heterodimer, None) " }

[]

{ "id": "2160", "sentence": "The critical region of THR beta was mapped to 3 amino acids in the distal box of the DNA binding domain .", "label": " ( protein: DNA binding domain, None) , ( protein: distal box, None) , ( protein: THR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNA binding domain, None) , ( protein: distal box, None) , ( protein: THR, None) " }

[]

{ "id": "2161", "sentence": "Hence, PPAR can positively or negatively influence TH action depending on TRE structure and THR isotype .", "label": " ( protein: THR, None) , ( DNA: TRE, None) , ( protein: THR isotype, None) , ( protein: PPAR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: THR, None) , ( DNA: TRE, None) , ( protein: THR isotype, None) , ( protein: PPAR, None) " }

[]

{ "id": "2162", "sentence": "Comparison of retinoic acid and phorbol myristate acetate as inducers of monocytic differentiation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2163", "sentence": "Several human myeloid leukemia cell lines growing in vitro can be induced to differentiate to more mature monocyte/macrophage-like cells by treatment with protein kinase C -activating phorbol esters , such as PMA .", "label": " ( cell line: human myeloid leukemia cell lines, None) , ( cell type: monocyte/macrophage-like cells, None) , ( protein: protein kinase C, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: human myeloid leukemia cell lines, None) , ( cell type: monocyte/macrophage-like cells, None) , ( protein: protein kinase C, None) " }

[]

{ "id": "2164", "sentence": "In addition to PMA , cells of the THP-1 myeloid leukemia cell line acquire macrophage-like characteristics after treatment with all-trans retinoic acid ( RA ).", "label": " ( cell line: THP-1 myeloid leukemia cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: THP-1 myeloid leukemia cell line, None) " }

[]

{ "id": "2165", "sentence": "To analyze the signal transduction mechanisms induced by RA , we first compared the effects of PMA and RA on the expression of genes which are known to be regulated during monocytic differentiation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2166", "sentence": "Both RA and PMA effectively down-regulated c-myc expression , while c-myb expression decreased only after PMA treatment .", "label": " ( DNA: c-myb, None) , ( DNA: c-myc, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: c-myb, None) , ( DNA: c-myc, None) " }

[]

{ "id": "2167", "sentence": "Expression of the beta 2-integrin genes , CD11a and CD11b , was clearly increased after both of these treatments.", "label": " ( DNA: CD11b, None) , ( DNA: CD11a, None) , ( DNA: beta 2-integrin genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: CD11b, None) , ( DNA: CD11a, None) , ( DNA: beta 2-integrin genes, None) " }

[]

{ "id": "2168", "sentence": "Their effects on the src-family tyrosine kinase genes were different: hck expression was similarly induced by these agents but lyn expression was stronger and more rapid after RA treatment .", "label": " ( DNA: src-family tyrosine kinase genes, None) , ( DNA: hck, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: src-family tyrosine kinase genes, None) , ( DNA: hck, None) " }

[]

{ "id": "2169", "sentence": "RA also enhanced lyn mRNA production rapidly in HL-60 , indicating that the activation of lyn gene expression is common in monocytic and granulocytic maturation of myeloid leukemia cells .", "label": " ( cell line: HL-60, None) , ( cell type: myeloid leukemia cells, None) , ( DNA: lyn gene, None) , ( RNA: lyn mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL-60, None) , ( cell type: myeloid leukemia cells, None) , ( DNA: lyn gene, None) , ( RNA: lyn mRNA, None) " }

[]

{ "id": "2170", "sentence": "To examine whether the AP-1 enhancer activity is involved in RA -induced monocytic differentiation , THP-1 cells were transiently transfected with a chloramphenicol acetyl transferase ( CAT )-reporter gene containing 5 copies of the AP-1 binding sites .", "label": " ( protein: chloramphenicol acetyl transferase, None) , ( protein: AP-1, None) , ( DNA: chloramphenicol acetyl transferase ( CAT )-reporter gene, None) , ( DNA: AP-1 binding sites, None) , ( cell line: THP-1 cells, None) , ( protein: CAT, None) , ( DNA: AP-1 enhancer, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: chloramphenicol acetyl transferase, None) , ( protein: AP-1, None) , ( DNA: chloramphenicol acetyl transferase ( CAT )-reporter gene, None) , ( DNA: AP-1 binding sites, None) , ( cell line: THP-1 cells, None) , ( protein: CAT, None) , ( DNA: AP-1 enhancer, None) " }

[]

{ "id": "2171", "sentence": "In contrast to PMA , RA did not induce any CAT activity in these cells, thus suggesting that the RA -induced changes in the expression of those genes described above were not dependent on the AP-1 enhancer activity .", "label": " ( protein: AP-1, None) , ( DNA: AP-1 enhancer, None) , ( protein: CAT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( DNA: AP-1 enhancer, None) , ( protein: CAT, None) " }

[]

{ "id": "2172", "sentence": "An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement .", "label": " ( protein: v-abl protein tyrosine kinase, None) , ( DNA: immunoglobulin light-chain gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: v-abl protein tyrosine kinase, None) , ( DNA: immunoglobulin light-chain gene, None) " }

[]

{ "id": "2173", "sentence": "Lymphoid cells transformed by Abelson murine leukemia virus have provided one of the classic models for study of early B-cell development and immunoglobulin rearrangement .", "label": " ( cell type: Lymphoid cells, None) , ( protein: immunoglobulin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: Lymphoid cells, None) , ( protein: immunoglobulin, None) " }

[]

{ "id": "2174", "sentence": "Most of these cells have rearranged their heavy-chain locus but not their light chain genes , suggesting that an active v-abl protein interferes with this differentiation step.", "label": " ( DNA: light chain genes, None) , ( DNA: heavy-chain locus, None) , ( protein: v-abl protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: light chain genes, None) , ( DNA: heavy-chain locus, None) , ( protein: v-abl protein, None) " }

[]

{ "id": "2175", "sentence": "To test this hypothesis, light-chain gene structure was examined in pre-B cells transformed by temperature-sensitive mutants of the Abelson virus and in derivatives that survive at the nonpermissive temperature because they express a human BCL-2 gene .", "label": " ( cell line: pre-B cells, None) , ( DNA: human BCL-2 gene, None) , ( DNA: light-chain gene structure, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: pre-B cells, None) , ( DNA: human BCL-2 gene, None) , ( DNA: light-chain gene structure, None) " }

[]

{ "id": "2176", "sentence": "Our studies reveal that inactivation of the v-abl protein tyrosine kinase triggers high-frequency rearrangement of kappa and lambda light-chain genes .", "label": " ( protein: v-abl protein, None) , ( protein: v-abl protein tyrosine kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: v-abl protein, None) , ( protein: v-abl protein tyrosine kinase, None) " }

[]

{ "id": "2177", "sentence": "These events are accompanied by marked increases in the expression of RAG-1 and RAG-2 RNAs .", "label": " ( RNA: RAG-1 and RAG-2 RNAs, None) , ( RNA: RAG-1, None) , ( RNA: RAG-2 RNAs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: RAG-1 and RAG-2 RNAs, None) , ( RNA: RAG-1, None) , ( RNA: RAG-2 RNAs, None) " }

[]

{ "id": "2178", "sentence": "These increases occur in the absence of protein synthesis but are dependent on inactivation of the v-abl protein tyrosine kinase .", "label": " ( protein: v-abl protein tyrosine kinase, None) , ( protein: v-abl protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: v-abl protein tyrosine kinase, None) , ( protein: v-abl protein, None) " }

[]

{ "id": "2179", "sentence": "As documented in the accompanying paper (Klug et al., this issue), an active v-abl protein also suppresses the activity of NF-kappa B /rel and expression controlled by the kappa intron enhancer .", "label": " ( protein: NF-kappa B /rel, None) , ( protein: NF-kappa B, None) , ( DNA: kappa intron enhancer, None) , ( protein: v-abl protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B /rel, None) , ( protein: NF-kappa B, None) , ( DNA: kappa intron enhancer, None) , ( protein: v-abl protein, None) " }

[]

{ "id": "2180", "sentence": "Together these data demonstrate that the v-abl protein specifically interferes with light-chain gene rearrangement by suppressing at least two pathways essential for this stage of B-cell differentiation and suggest that tyrosine phosphorylation is important in regulating RAG gene expression .", "label": " ( protein: v-abl protein, None) , ( DNA: light-chain gene, None) , ( DNA: RAG gene, None) , ( cell type: B-cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: v-abl protein, None) , ( DNA: light-chain gene, None) , ( DNA: RAG gene, None) , ( cell type: B-cell, None) " }

[]

{ "id": "2181", "sentence": "Calcium signalling in T cells stimulated by a cyclophilin B-binding protein .", "label": " ( protein: cyclophilin B-binding protein, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cyclophilin B-binding protein, None) , ( cell type: T cells, None) " }

[]

{ "id": "2182", "sentence": "The immunosuppressant drug cyclosporin A blocks a calcium -dependent signal from the T-cell receptor ( TCR ) that normally leads to T-cell activation .", "label": " ( protein: TCR, None) , ( protein: T-cell receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TCR, None) , ( protein: T-cell receptor, None) " }

[]

{ "id": "2183", "sentence": "When bound to cyclophilin , cyclosporin A binds and inactivates the key signalling intermediate calcineurin .", "label": " ( protein: cyclophilin, None) , ( protein: calcineurin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cyclophilin, None) , ( protein: calcineurin, None) " }

[]

{ "id": "2184", "sentence": "To identify potential cellular homologues of cyclosporin A that might regulate calcium signalling , we have cloned human genes encoding cyclophilin B-binding-proteins using the yeast two-hybrid system .", "label": " ( protein: cyclophilin B-binding-proteins, None) , ( protein: cyclophilin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cyclophilin B-binding-proteins, None) , ( protein: cyclophilin, None) " }

[]

{ "id": "2185", "sentence": "One gene product, when overexpressed in Jurkat T cells , specifically induced transcription from the interleukin-2 enhancer , by activating the T-cell-specific transcription factors NF-AT and NF-IL2A .", "label": " ( protein: NF-AT, None) , ( DNA: interleukin-2 enhancer, None) , ( protein: T-cell-specific transcription factors, None) , ( protein: NF-IL2A, None) , ( cell line: Jurkat T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT, None) , ( DNA: interleukin-2 enhancer, None) , ( protein: T-cell-specific transcription factors, None) , ( protein: NF-IL2A, None) , ( cell line: Jurkat T cells, None) " }

[]

{ "id": "2186", "sentence": "This protein, termed calcium -signal modulating cyclophilin ligand ( CAML ), acts downstream of the TCR and upstream of calcineurin by causing an influx of calcium .", "label": " ( protein: CAML, None) , ( protein: TCR, None) , ( protein: calcium -signal modulating cyclophilin ligand, None) , ( protein: calcineurin, None) , ( protein: cyclophilin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CAML, None) , ( protein: TCR, None) , ( protein: calcium -signal modulating cyclophilin ligand, None) , ( protein: calcineurin, None) , ( protein: cyclophilin, None) " }

[]

{ "id": "2187", "sentence": "CAML appears to be a new participant in the calcium -signal transduction pathway , implicating cyclophilin B in calcium signalling , even in the absence of cyclosporin .", "label": " ( protein: CAML, None) , ( protein: cyclophilin B, None) , ( protein: cyclophilin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CAML, None) , ( protein: cyclophilin B, None) , ( protein: cyclophilin, None) " }

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{ "id": "2188", "sentence": "Expression and genomic configuration of GM-CSF , IL-3 , M-CSF receptor ( C-FMS ), early growth response gene-1 ( EGR-1 ) and M-CSF genes in primary myelodysplastic syndromes .", "label": " ( DNA: early growth response gene-1, None) , ( DNA: M-CSF genes, None) , ( DNA: EGR-1, None) , ( protein: C-FMS, None) , ( protein: IL-3, None) , ( protein: GM-CSF, None) , ( protein: M-CSF receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: early growth response gene-1, None) , ( DNA: M-CSF genes, None) , ( DNA: EGR-1, None) , ( protein: C-FMS, None) , ( protein: IL-3, None) , ( protein: GM-CSF, None) , ( protein: M-CSF receptor, None) " }

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{ "id": "2189", "sentence": "Peripheral blood mononuclear cells from seventeen patients with primary myelodysplastic syndromes ( MDS ) in advanced stage were enriched for blasts and tested for (1) karyotype , (2) genomic configuration and (3) expression of IL-3 , GM-CSF , FMS and EGR-1 genes which are all located on the long arm of chromosome 5 .", "label": " ( DNA: long arm of chromosome 5, None) , ( DNA: chromosome 5, None) , ( cell type: blasts, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: long arm of chromosome 5, None) , ( DNA: chromosome 5, None) , ( cell type: blasts, None) " }

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{ "id": "2190", "sentence": "The expression of the M-CSF gene , that has been recently reassigned to the short arm of chromosome 1 ( lp ), was also investigated.", "label": " ( DNA: chromosome 1, None) , ( DNA: lp, None) , ( DNA: M-CSF gene, None) , ( DNA: short arm of chromosome 1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: chromosome 1, None) , ( DNA: lp, None) , ( DNA: M-CSF gene, None) , ( DNA: short arm of chromosome 1, None) " }

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{ "id": "2191", "sentence": "Aims of the study were to (1) assess the potential role of the expression of these genes in the maintenance and expansion of the neoplastic clones and (2) search for constitutional losses or rearrangements of one allele followed by a deletion of the second allele of the same genes in the leukemic cells .", "label": " ( DNA: allele, None) , ( cell type: leukemic cells, None) , ( cell line: neoplastic clones, None) , ( DNA: allele, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: allele, None) , ( cell type: leukemic cells, None) , ( cell line: neoplastic clones, None) , ( DNA: allele, None) " }

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{ "id": "2192", "sentence": "The latter issue was investigated by comparing, in 8 cases, constitutive DNA from skin fibroblasts with leukemic DNA .", "label": " ( DNA: constitutive DNA, None) , ( cell type: skin fibroblasts, None) , ( DNA: leukemic DNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: constitutive DNA, None) , ( cell type: skin fibroblasts, None) , ( DNA: leukemic DNA, None) " }

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{ "id": "2193", "sentence": "Eleven of the 17 patients had abnormal karyotypes .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2194", "sentence": "The M-CSF gene was expressed in 6 cases and the FMS and the EGR-1 genes were expressed in 2 of the latter cases.", "label": " ( DNA: EGR-1, None) , ( DNA: M-CSF gene, None) , ( DNA: EGR-1 genes, None) , ( DNA: FMS, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: EGR-1, None) , ( DNA: M-CSF gene, None) , ( DNA: EGR-1 genes, None) , ( DNA: FMS, None) " }

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{ "id": "2195", "sentence": "An autocrine mechanism of growth could be hypothesized only for the 2 patients whose cells expressed both the M-CSF and FMS genes .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2196", "sentence": "No germline changes or rearrangements were observed in any of the genes studied.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2197", "sentence": "Thus, deregulation of genes encoding for certain hemopoietic growth factors or receptors does not seem to represent a major mechanism of MDS progression .", "label": " ( protein: hemopoietic growth factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hemopoietic growth factors, None) " }

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{ "id": "2198", "sentence": "A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues .", "label": " ( DNA: proboscipedia, None) , ( DNA: human homeobox gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: proboscipedia, None) , ( DNA: human homeobox gene, None) " }

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{ "id": "2199", "sentence": "A novel human homeobox gene , HB9 , was isolated from a cDNA library prepared from in vitro stimulated human tonsil B lymphocytes and from a human genomic library .", "label": " ( cell type: vitro stimulated human tonsil B lymphocytes, None) , ( DNA: human genomic library, None) , ( DNA: cDNA library, None) , ( DNA: HB9, None) , ( DNA: human homeobox gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: vitro stimulated human tonsil B lymphocytes, None) , ( DNA: human genomic library, None) , ( DNA: cDNA library, None) , ( DNA: HB9, None) , ( DNA: human homeobox gene, None) " }