Datasets:

huy-nh-2000

/

instructUIE

like 0

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{ "id": "1600", "sentence": "A unique region containing four or five near-perfect direct repeats ( DR ) of 21 bp with one 12-bp insert was proven to be the main transcription-activation element , with enhancer-like characteristics .", "label": " ( DNA: direct repeats, None) , ( DNA: DR, None) , ( DNA: 12-bp insert, None) , ( DNA: transcription-activation element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: direct repeats, None) , ( DNA: DR, None) , ( DNA: 12-bp insert, None) , ( DNA: transcription-activation element, None) " }

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{ "id": "1601", "sentence": "PCR studies revealed that CAV isolates from across the world all contained this promoter sequence .", "label": " ( DNA: promoter sequence, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: promoter sequence, None) " }

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{ "id": "1602", "sentence": "Electrophoretic mobility-shift assays ( EMSA ) showed that individual DR units , as well as the 12-bp insert , can bind to nuclear factors of chicken T-cells .", "label": " ( protein: nuclear factors, None) , ( cell type: chicken T-cells, None) , ( DNA: 12-bp insert, None) , ( DNA: individual DR units, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factors, None) , ( cell type: chicken T-cells, None) , ( DNA: 12-bp insert, None) , ( DNA: individual DR units, None) " }

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{ "id": "1603", "sentence": "Competition assays revealed that the DR units bound to factors other than the 12-bp insert .", "label": " ( DNA: DR units, None) , ( DNA: 12-bp insert, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: DR units, None) , ( DNA: 12-bp insert, None) " }

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{ "id": "1604", "sentence": "A synthetic oligodeoxyribonucleotide containing an SP1-box ( 5'-GGGCGG ) could compete with factors binding to the 12-bp insert .", "label": " ( DNA: 12-bp insert, None) , ( DNA: SP1-box, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: 12-bp insert, None) , ( DNA: SP1-box, None) " }

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{ "id": "1605", "sentence": "Purified human SP1 was shown to have very strong affinity for the 12-bp insert .", "label": " ( protein: human SP1, None) , ( DNA: 12-bp insert, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: human SP1, None) , ( DNA: 12-bp insert, None) " }

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{ "id": "1606", "sentence": "Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas .", "label": " ( protein: Myc-Max heterodimer, None) , ( cell line: T cell hybridomas, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Myc-Max heterodimer, None) , ( cell line: T cell hybridomas, None) " }

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{ "id": "1607", "sentence": "T cell hybridomas respond to activation signals by undergoing apoptotic cell death , and this is likely to represent comparable events related to tolerance induction in immature and mature T cells in vivo.", "label": " ( cell line: T cell hybridomas, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: T cell hybridomas, None) " }

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{ "id": "1608", "sentence": "Previous studies using antisense oligonucleotides implicated the c-Myc protein in the phenomenon of activation-induced apoptosis .", "label": " ( protein: c-Myc protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c-Myc protein, None) " }

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{ "id": "1609", "sentence": "This role for c-Myc in apoptosis is now confirmed in studies using a dominant negative form of its heterodimeric binding partner, Max , which we show here inhibits activation-induced apoptosis .", "label": " ( protein: Max, None) , ( protein: c-Myc, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Max, None) , ( protein: c-Myc, None) " }

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{ "id": "1610", "sentence": "Further, coexpression of a reciprocally mutant Myc protein capable of forming functional heterodimers with the mutant Max can compensate for the dominant negative activity and restore activation-induced apoptosis .", "label": " ( protein: heterodimers, None) , ( protein: reciprocally mutant Myc protein, None) , ( protein: Max, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: heterodimers, None) , ( protein: reciprocally mutant Myc protein, None) , ( protein: Max, None) " }

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{ "id": "1611", "sentence": "These results imply that Myc promotes activation-induced apoptosis by obligatory heterodimerization with Max , and therefore, by regulating gene transcription .", "label": " ( protein: Max, None) , ( protein: Myc, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Max, None) , ( protein: Myc, None) " }

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{ "id": "1612", "sentence": "Epstein-Barr virus SM protein .", "label": " ( protein: Epstein-Barr virus SM protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Epstein-Barr virus SM protein, None) " }

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{ "id": "1613", "sentence": "The protein products of the Epstein-Barr virus ( EBV ) BMLF1 open reading frame have been characterized in the early productive cycle in B95-8 and Akata cells .", "label": " ( DNA: Epstein-Barr virus ( EBV ) BMLF1 open reading frame, None) , ( cell line: B95-8, None) , ( cell line: Akata cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Epstein-Barr virus ( EBV ) BMLF1 open reading frame, None) , ( cell line: B95-8, None) , ( cell line: Akata cells, None) " }

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{ "id": "1614", "sentence": "The SM protein derived from the spliced RNA joining BSLF2 to BMLF1 is much the most abundant protein.", "label": " ( protein: BMLF1, None) , ( protein: SM protein, None) , ( protein: BSLF2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: BMLF1, None) , ( protein: SM protein, None) , ( protein: BSLF2, None) " }

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{ "id": "1615", "sentence": "SM is a phosphoprotein in EBV -infected cells and can be phosphorylated in vitro with casein kinase II ( CKII ).", "label": " ( protein: SM, None) , ( protein: CKII, None) , ( protein: phosphoprotein, None) , ( cell type: -infected cells, None) , ( protein: casein kinase II, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: SM, None) , ( protein: CKII, None) , ( protein: phosphoprotein, None) , ( cell type: -infected cells, None) , ( protein: casein kinase II, None) " }

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{ "id": "1616", "sentence": "Computer analysis of the SM protein sequence showed a C terminal section of SM to be related to genome positional homologues of four other herpesviruses and revealed consensus CKII sites near the N termini of the EBV SM protein , the herpes simplex virus ( HSV ) ICP27 protein and the herpesvirus saimiri ( HVS ) open reading frame 57 protein .", "label": " ( protein: CKII, None) , ( protein: SM, None) , ( protein: genome positional homologues, None) , ( protein: N termini, None) , ( protein: consensus CKII sites, None) , ( protein: SM protein, None) , ( protein: herpesvirus saimiri ( HVS ) open reading frame 57 protein, None) , ( protein: C terminal section, None) , ( protein: SM protein sequence, None) , ( protein: SM protein, None) , ( protein: SM, None) , ( protein: EBV SM protein, None) , ( protein: herpes simplex virus ( HSV ) ICP27 protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CKII, None) , ( protein: SM, None) , ( protein: genome positional homologues, None) , ( protein: N termini, None) , ( protein: consensus CKII sites, None) , ( protein: SM protein, None) , ( protein: herpesvirus saimiri ( HVS ) open reading frame 57 protein, None) , ( protein: C terminal section, None) , ( protein: SM protein sequence, None) , ( protein: SM protein, None) , ( protein: SM, None) , ( protein: EBV SM protein, None) , ( protein: herpes simplex virus ( HSV ) ICP27 protein, None) " }

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{ "id": "1617", "sentence": "Site-directed mutagenesis of the consensus CKII site in EBV SM greatly reduced the in vitro phosphorylation of SM by CKII .", "label": " ( DNA: consensus CKII site, None) , ( protein: CKII, None) , ( protein: SM, None) , ( protein: CKII, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: consensus CKII site, None) , ( protein: CKII, None) , ( protein: SM, None) , ( protein: CKII, None) " }

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{ "id": "1618", "sentence": "The mechanism of transactivation by BMLF1 proteins has been controversial but SM was shown to transactivate gene expression from a CAT reporter construct by increasing the amount of cytoplasmic CAT mRNA .", "label": " ( protein: BMLF1, None) , ( protein: BMLF1 proteins, None) , ( DNA: CAT reporter construct, None) , ( RNA: cytoplasmic CAT mRNA, None) , ( protein: SM, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: BMLF1, None) , ( protein: BMLF1 proteins, None) , ( DNA: CAT reporter construct, None) , ( RNA: cytoplasmic CAT mRNA, None) , ( protein: SM, None) " }

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{ "id": "1619", "sentence": "Mutagenesis of the CKII site in SM made no difference to the transactivation in this transient transfection assay .", "label": " ( protein: CKII, None) , ( protein: SM, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CKII, None) , ( protein: SM, None) " }

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{ "id": "1620", "sentence": "Inducible binding to the c-fos serum response element during T cell activation is regulated by a phosphotyrosine-containing protein .", "label": " ( protein: phosphotyrosine-containing protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: phosphotyrosine-containing protein, None) " }

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{ "id": "1621", "sentence": "The proto-oncogene c-fos is an immediate-early gene , and one of the first genes transcribed after stimulation of most cells with a variety of ligands.", "label": " ( DNA: proto-oncogene c-fos, None) , ( DNA: immediate-early gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: proto-oncogene c-fos, None) , ( DNA: immediate-early gene, None) " }

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{ "id": "1622", "sentence": "Fos expression may be a pivotal event in converting ligand-receptor interactions at the membrane into functional modulation of cell phenotype .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1623", "sentence": "The serum response element ( SRE ) in the c-fos regulatory region participates in induction of transcription by various growth factors and by phorbol esters and subsequent squelching of transcription.", "label": " ( DNA: SRE, None) , ( DNA: c-fos regulatory region, None) , ( protein: growth factors, None) , ( DNA: serum response element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: SRE, None) , ( DNA: c-fos regulatory region, None) , ( protein: growth factors, None) , ( DNA: serum response element, None) " }

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{ "id": "1624", "sentence": "We show that an inducible protein complex ( Band A ) binds to SRE DNA within 10 min after mitogenic stimulation of human PBL-T , and becomes nondetectable by 60 min.", "label": " ( DNA: SRE DNA, None) , ( cell line: human PBL-T, None) , ( DNA: SRE, None) , ( protein: protein complex, None) , ( protein: Band A, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: SRE DNA, None) , ( cell line: human PBL-T, None) , ( DNA: SRE, None) , ( protein: protein complex, None) , ( protein: Band A, None) " }

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{ "id": "1625", "sentence": "Band A contains the serum response factor plus additional factor(s).", "label": " ( protein: serum response factor, None) , ( protein: Band A, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: serum response factor, None) , ( protein: Band A, None) " }

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{ "id": "1626", "sentence": "A protein that is phosphorylated on a tyrosine residue in resting PBL-T suppresses binding of a component of Band A to the SRE motif .", "label": " ( protein: Band A, None) , ( DNA: SRE motif, None) , ( DNA: SRE, None) , ( cell line: resting PBL-T, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Band A, None) , ( DNA: SRE motif, None) , ( DNA: SRE, None) , ( cell line: resting PBL-T, None) " }

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{ "id": "1627", "sentence": "Upon stimulation of the cells, this protein no longer prevents binding of DNA by Band A , and suppression of binding is restored within 30 min.", "label": " ( protein: Band A, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Band A, None) " }

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{ "id": "1628", "sentence": "The phosphorylated tyrosine residue itself is important for the protein-protein interaction .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1629", "sentence": "In vivo modification of major histocompatibility complex class II DRA promoter occupancy mediated by the AIR-1 trans-activator .", "label": " ( protein: major histocompatibility complex class II, None) , ( DNA: major histocompatibility complex class II DRA promoter, None) , ( protein: AIR-1 trans-activator, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: major histocompatibility complex class II, None) , ( DNA: major histocompatibility complex class II DRA promoter, None) , ( protein: AIR-1 trans-activator, None) " }

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{ "id": "1630", "sentence": "RJ 2.2.5 is a human B cell mutant derived from the Burkitt lymphoma Raji cell which is defective in the AIR-1 locus function .", "label": " ( cell line: RJ 2.2.5, None) , ( cell line: human B cell mutant, None) , ( cell line: Burkitt lymphoma Raji cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: RJ 2.2.5, None) , ( cell line: human B cell mutant, None) , ( cell line: Burkitt lymphoma Raji cell, None) " }

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{ "id": "1631", "sentence": "This locus encodes a transcriptional trans-activator required for the constitutive expression of major histocompatibility complex (MHC) class II genes .", "label": " ( DNA: major histocompatibility complex (MHC) class II genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: major histocompatibility complex (MHC) class II genes, None) " }

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{ "id": "1632", "sentence": "Here we show, by in vivo DNase I footprinting , that the AIR-1 locus defect correlates with changes in the DRA promoter occupancy .", "label": " ( DNA: AIR-1 locus defect, None) , ( protein: DNase I, None) , ( DNA: DRA promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: AIR-1 locus defect, None) , ( protein: DNase I, None) , ( DNA: DRA promoter, None) " }

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{ "id": "1633", "sentence": "Interestingly, reexpression of human MHC class II genes in RJ 2.2.5 x mouse spleen cell hybrids is associated with partial reversion of DRA promoter occupancy to the Raji pattern .", "label": " ( DNA: human MHC class II genes, None) , ( cell line: RJ 2.2.5 x mouse spleen cell hybrids, None) , ( DNA: DRA promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: human MHC class II genes, None) , ( cell line: RJ 2.2.5 x mouse spleen cell hybrids, None) , ( DNA: DRA promoter, None) " }

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{ "id": "1634", "sentence": "DRA promoter occupancy in other class II-negative B cell lines , derived from patients with bare lymphocyte syndrome , is drastically different from the one observed in RJ 2.2.5 and Raji cells .", "label": " ( cell line: class II-negative B cell lines, None) , ( cell line: Raji cells, None) , ( DNA: DRA promoter, None) , ( cell line: RJ 2.2.5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: class II-negative B cell lines, None) , ( cell line: Raji cells, None) , ( DNA: DRA promoter, None) , ( cell line: RJ 2.2.5, None) " }

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{ "id": "1635", "sentence": "Moreover, the use of the DNase I as an in vivo footprinting agent reveals that the patients ' cell lines do not display a completely \" bare promoter \" as previously reported using dimethyl sulfate as the footprinting agent .", "label": " ( DNA: bare promoter, None) , ( cell line: patients #$%# cell lines, None) , ( protein: DNase I, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: bare promoter, None) , ( cell line: patients #$%# cell lines, None) , ( protein: DNase I, None) " }

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{ "id": "1636", "sentence": "Thus, the use of DNase I allowed us, for the first time, to correlate the AIR-1 locus defect with class II promoter occupancy alterations and distinguish these alterations from the ones observed in phenotypically similar but genetically distinct MHC class II-negative cells .", "label": " ( protein: DNase I, None) , ( DNA: class II promoter, None) , ( DNA: AIR-1 locus defect, None) , ( cell line: MHC class II-negative cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNase I, None) , ( DNA: class II promoter, None) , ( DNA: AIR-1 locus defect, None) , ( cell line: MHC class II-negative cells, None) " }

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{ "id": "1637", "sentence": "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression : potential role of physical interactions between Elf-1 , HMG-I(Y) , and NF-kappa B family proteins .", "label": " ( protein: Elf-1, None) , ( protein: interleukin-2 receptor alpha-chain, None) , ( protein: NF-kappa B family proteins, None) , ( protein: HMG-I(Y), None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Elf-1, None) , ( protein: interleukin-2 receptor alpha-chain, None) , ( protein: NF-kappa B family proteins, None) , ( protein: HMG-I(Y), None) " }

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{ "id": "1638", "sentence": "The interleukin 2 receptor alpha-chain ( IL-2R alpha ) gene is rapidly and potently induced in T cells in response to mitogenic stimuli.", "label": " ( protein: IL-2R alpha, None) , ( protein: interleukin 2 receptor alpha-chain, None) , ( cell type: T cells, None) , ( DNA: interleukin 2 receptor alpha-chain ( IL-2R alpha ) gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2R alpha, None) , ( protein: interleukin 2 receptor alpha-chain, None) , ( cell type: T cells, None) , ( DNA: interleukin 2 receptor alpha-chain ( IL-2R alpha ) gene, None) " }

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{ "id": "1639", "sentence": "Previously, an inducible enhancer between nucleotides -299 and -228 that contains NF-kappa B and CArG motifs was identified.", "label": " ( DNA: inducible enhancer, None) , ( DNA: nucleotides -299 and -228, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: inducible enhancer, None) , ( DNA: nucleotides -299 and -228, None) " }

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{ "id": "1640", "sentence": "We now report the characterization of a second essential positive regulatory element located between nucleotides -137 and -64 that binds Elf-1 and HMG-I(Y) .", "label": " ( DNA: essential positive regulatory element, None) , ( protein: HMG-I(Y), None) , ( DNA: nucleotides -137 and -64, None) , ( protein: Elf-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: essential positive regulatory element, None) , ( protein: HMG-I(Y), None) , ( DNA: nucleotides -137 and -64, None) , ( protein: Elf-1, None) " }

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{ "id": "1641", "sentence": "This element had maximal activity in lymphoid cells , paralleling the cell type specificity of Elf-1 expression .", "label": " ( protein: Elf-1, None) , ( cell type: lymphoid cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Elf-1, None) , ( cell type: lymphoid cells, None) " }

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{ "id": "1642", "sentence": "Transcription from the IL-2R alpha promoter was inhibited when either the Elf-1 or the HMG-I(Y) binding site was mutated.", "label": " ( protein: HMG-I(Y), None) , ( DNA: IL-2R alpha promoter, None) , ( protein: IL-2R alpha, None) , ( protein: Elf-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HMG-I(Y), None) , ( DNA: IL-2R alpha promoter, None) , ( protein: IL-2R alpha, None) , ( protein: Elf-1, None) " }

[]

{ "id": "1643", "sentence": "Coexpression of both proteins activated transcription of the -137 to -64 element in COS-7 cells .", "label": " ( cell line: COS-7 cells, None) , ( DNA: -137 to -64 element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: COS-7 cells, None) , ( DNA: -137 to -64 element, None) " }

[]

{ "id": "1644", "sentence": "Elf-1 physically associated with HMG-I and with NF-kappa B p50 and c-Rel in vitro, suggesting that protein-protein interactions might functionally coordinate the actions of the upstream and downstream positive regulatory elements .", "label": " ( protein: NF-kappa B, None) , ( protein: HMG-I, None) , ( protein: Elf-1, None) , ( protein: c-Rel, None) , ( protein: p50, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: HMG-I, None) , ( protein: Elf-1, None) , ( protein: c-Rel, None) , ( protein: p50, None) " }

[]

{ "id": "1645", "sentence": "This is the first report of a physical interaction between an Ets family member and NF-kappa B family proteins .", "label": " ( protein: NF-kappa B family proteins, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B family proteins, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "1646", "sentence": "These findings provide significant new insights into the protein-protein and protein-DNA interactions that regulate cell-type-specific and inducible IL-2R alpha gene expression and also have implications for other genes regulated by Elf-1 and NF-kappa B family proteins .", "label": " ( protein: Elf-1, None) , ( protein: NF-kappa B, None) , ( protein: IL-2R alpha, None) , ( protein: NF-kappa B family proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Elf-1, None) , ( protein: NF-kappa B, None) , ( protein: IL-2R alpha, None) , ( protein: NF-kappa B family proteins, None) " }

[]

{ "id": "1647", "sentence": "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937 .", "label": " ( cell line: human monoblast cell line U-937, None) , ( protein: Kruppel-related zinc finger proteins, None) , ( DNA: cDNA clones, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: human monoblast cell line U-937, None) , ( protein: Kruppel-related zinc finger proteins, None) , ( DNA: cDNA clones, None) " }

[]

{ "id": "1648", "sentence": "To study the complexity and structural characteristics of zinc finger proteins expressed during human hematopoiesis and to isolate novel regulators of blood cell development , a degenerate oligonucleotide probe specific for a consensus zinc finger peptide domain was used to isolate 63 cDNA clones for Kruppel-related zinc finger genes from the human monoblast cell line U-937 .", "label": " ( cell line: human monoblast cell line U-937, None) , ( protein: zinc finger proteins, None) , ( DNA: Kruppel-related zinc finger genes, None) , ( DNA: cDNA clones, None) , ( protein: consensus zinc finger peptide domain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: human monoblast cell line U-937, None) , ( protein: zinc finger proteins, None) , ( DNA: Kruppel-related zinc finger genes, None) , ( DNA: cDNA clones, None) , ( protein: consensus zinc finger peptide domain, None) " }

[]

{ "id": "1649", "sentence": "By extensive nucleotide sequence and Northern blot analysis , these cDNA clones were found to originate from approximately 42 different genes ( HZF 1-42 ) of which only 8 have previously been described.", "label": " ( DNA: cDNA clones, None) , ( DNA: HZF 1-42, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: cDNA clones, None) , ( DNA: HZF 1-42, None) " }

[]

{ "id": "1650", "sentence": "Northern blot analysis showed that a majority of these genes were expressed at comparable levels in U-937 and HeLa cells .", "label": " ( cell line: U-937, None) , ( cell line: HeLa cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: U-937, None) , ( cell line: HeLa cells, None) " }

[]

{ "id": "1651", "sentence": "The large number of individual genes represented among the 63 clones and their apparent non-cell-type-specific expression suggest that the majority of the Kruppel-related zinc finger genes are likely to be expressed in most human tissues .", "label": " ( DNA: Kruppel-related zinc finger genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Kruppel-related zinc finger genes, None) " }

[]

{ "id": "1652", "sentence": "In contrast, some of the genes displayed a restricted expression pattern, indicating that they represent potential regulators of monocyte differentiation or proliferation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1653", "sentence": "Detailed structural analysis of the first 12 cDNAs ( HZF 1-10 ) and a partial characterization of HZF 11-42 revealed that a common feature of human Kruppel-related zinc finger proteins is the presence of tandem arrays of zinc fingers ranging in number from 3 to over 20 that are preferentially located in the carboxy-terminal regions of the proteins.", "label": " ( protein: zinc finger proteins, None) , ( protein: Kruppel-related zinc finger proteins, None) , ( DNA: HZF 11-42, None) , ( protein: zinc fingers, None) , ( protein: carboxy-terminal regions, None) , ( DNA: cDNAs, None) , ( protein: human Kruppel-related zinc finger proteins, None) , ( DNA: HZF 1-10, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: zinc finger proteins, None) , ( protein: Kruppel-related zinc finger proteins, None) , ( DNA: HZF 11-42, None) , ( protein: zinc fingers, None) , ( protein: carboxy-terminal regions, None) , ( DNA: cDNAs, None) , ( protein: human Kruppel-related zinc finger proteins, None) , ( DNA: HZF 1-10, None) " }

[]

{ "id": "1654", "sentence": "In addition, several novel KRAB-containing zinc finger genes and a novel conserved sequence element were identified.", "label": " ( DNA: KRAB-containing zinc finger genes, None) , ( DNA: conserved sequence element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: KRAB-containing zinc finger genes, None) , ( DNA: conserved sequence element, None) " }

[]

{ "id": "1655", "sentence": "CAG repeat length variation in sperm from a patient with Kennedy's disease .", "label": " ( cell type: sperm, None) , ( DNA: CAG repeat length variation, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: sperm, None) , ( DNA: CAG repeat length variation, None) " }

[]

{ "id": "1656", "sentence": "Using a modified sperm typing protocol , the mutation frequency of the CAG repeat region at the androgen receptor locus has been measured using a rare semen sample from an individual with spinal and bulbar muscular atrophy ( SBMA ).", "label": " ( cell type: sperm, None) , ( DNA: CAG repeat region, None) , ( DNA: androgen receptor locus, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: sperm, None) , ( DNA: CAG repeat region, None) , ( DNA: androgen receptor locus, None) " }

[]

{ "id": "1657", "sentence": "Among 258 X chromosome-containing sperm , 19% had a repeat number equal to the donor's somatic DNA (47 repeats), 66% were expansions and 15% were contractions .", "label": " ( DNA: donor#$%#s somatic DNA, None) , ( cell type: sperm, None) , ( cell type: X chromosome-containing sperm, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: donor#$%#s somatic DNA, None) , ( cell type: sperm, None) , ( cell type: X chromosome-containing sperm, None) " }

[]

{ "id": "1658", "sentence": "The average expansion was 2.7 repeats.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1659", "sentence": "More than half of the expansions involved one or two repeats; the largest was 11 repeats.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1660", "sentence": "68% of the contractions were also one or two repeats but six (16%) were very large (12-25 repeats).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1661", "sentence": "One contraction generated an allele in an intermediate size range (33-39 repeats).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1662", "sentence": "Such alleles have not been observed among more than 900 normal and SBMA X-chromosomes that have been examined.", "label": " ( DNA: SBMA X-chromosomes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: SBMA X-chromosomes, None) " }

[]

{ "id": "1663", "sentence": "Comparison of the SBMA sperm typing results with mutation frequency data on normal alleles supports the hypothesis that trinucleotide repeat expansions may have a different molecular origin than contractions .", "label": " ( cell type: sperm, None) , ( DNA: trinucleotide repeat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: sperm, None) , ( DNA: trinucleotide repeat, None) " }

[]

{ "id": "1664", "sentence": "Aspirin-like drugs can protect human T lymphocytes against benzoquinone cytotoxicity : evidence for a NAD(P)H:quinone reductase -dependent mechanism .", "label": " ( protein: NAD(P)H:quinone reductase, None) , ( cell type: human T lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NAD(P)H:quinone reductase, None) , ( cell type: human T lymphocytes, None) " }

[]

{ "id": "1665", "sentence": "Benzene toxicity towards lymphocytes is thought to be mediated by metabolites of benzene including benzoquinone ( BQ ).", "label": " ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphocytes, None) " }

[]

{ "id": "1666", "sentence": "NAD(P)H:quinone reductase ( QR ) is known to protect against BQ toxicity .", "label": " ( protein: NAD(P)H:quinone reductase, None) , ( protein: QR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NAD(P)H:quinone reductase, None) , ( protein: QR, None) " }

[]

{ "id": "1667", "sentence": "The expression of the QR gene is regulated by the transcription factor AP-1 .", "label": " ( DNA: QR gene, None) , ( protein: transcription factor, None) , ( protein: AP-1, None) , ( protein: QR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: QR gene, None) , ( protein: transcription factor, None) , ( protein: AP-1, None) , ( protein: QR, None) " }

[]

{ "id": "1668", "sentence": "We had previously found that aspirin-like drugs ( ALD ) induce AP-1 in human T lymphocytes .", "label": " ( protein: AP-1, None) , ( cell type: human T lymphocytes, None) , ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( cell type: human T lymphocytes, None) , ( cell type: lymphocytes, None) " }

[]

{ "id": "1669", "sentence": "It was therefore hypothesized that ALD would protect lymphocytes against BQ toxicity by inducing QR .", "label": " ( cell type: lymphocytes, None) , ( protein: QR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphocytes, None) , ( protein: QR, None) " }

[]

{ "id": "1670", "sentence": "Molt-4 cells ( M4 ), a human T lymphocyte cell line , were incubated with different concentrations of two ALD , flurbiprofen and sodium diclofenac , and then exposed to BQ .", "label": " ( cell line: M4, None) , ( cell line: human T lymphocyte cell line, None) , ( cell line: Molt-4 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: M4, None) , ( cell line: human T lymphocyte cell line, None) , ( cell line: Molt-4 cells, None) " }

[]

{ "id": "1671", "sentence": "Toxicity was measured by viability ( trypan blue exclusion ).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1672", "sentence": "Both drugs protected the cells against BQ cytotoxicity in a dose-dependent manner , e.g., sodium diclofenac at 15 microM reduced the fraction of BQ -treated dead cells by 70%.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1673", "sentence": "ALDs induced QR activity in the M4 cells in the same range of concentrations that protected the cells against BQ toxicity.", "label": " ( protein: QR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: QR, None) " }

[]

{ "id": "1674", "sentence": "The protective effect of ALD was significantly reduced by dicoumarol , a QR -specific inhibitor .", "label": " ( protein: QR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: QR, None) " }

[]

{ "id": "1675", "sentence": "Since human T cells and T cell lines do not metabolize arachidonic acid, our data suggest that ALD can protect human T lymphocytes against a metabolite of benzene by induction of QR activity .", "label": " ( protein: QR, None) , ( cell type: T cell lines, None) , ( cell type: human T lymphocytes, None) , ( cell type: lymphocytes, None) , ( cell type: human T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: QR, None) , ( cell type: T cell lines, None) , ( cell type: human T lymphocytes, None) , ( cell type: lymphocytes, None) , ( cell type: human T cells, None) " }

[]

{ "id": "1676", "sentence": "Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4 .", "label": " ( cell line: HL-60, None) , ( cell line: human leukemia cell lines, None) , ( cell line: NB4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL-60, None) , ( cell line: human leukemia cell lines, None) , ( cell line: NB4, None) " }

[]

{ "id": "1677", "sentence": "Retinoids , including all-trans-retinoic acid , its isomers, and fifty synthetic retinoids (retinobenzoic acids), were tested for differentiation-inducing activity on human leukemia cell lines HL-60 and NB4 .", "label": " ( cell line: NB4, None) , ( cell line: HL-60, None) , ( cell line: human leukemia cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: NB4, None) , ( cell line: HL-60, None) , ( cell line: human leukemia cell lines, None) " }

[]

{ "id": "1678", "sentence": "A good linear correlation, with an r value of 0.91, between the ED50 values for the differentiation-inducing activity towards HL-60 cells and that towards NB4 cells was found.", "label": " ( cell line: HL-60 cells, None) , ( cell line: NB4 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL-60 cells, None) , ( cell line: NB4 cells, None) " }

[]

{ "id": "1679", "sentence": "Platelet-activating factor ( PAF ) positively auto-regulates the expression of human PAF receptor transcript 1 ( leukocyte-type ) through NF-kappa B .", "label": " ( protein: PAF, None) , ( protein: human PAF receptor transcript 1, None) , ( protein: NF-kappa B, None) , ( protein: Platelet-activating factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PAF, None) , ( protein: human PAF receptor transcript 1, None) , ( protein: NF-kappa B, None) , ( protein: Platelet-activating factor, None) " }

[]

{ "id": "1680", "sentence": "The human platelet-activating factor receptor ( PAFR ) gene is transcribed by two distinct promoters ( promoter 1 and promoter 2 ) to generate two transcripts (designated as PAFR transcript 1 and PAFR transcript 2 ), though their open reading frames are identical.", "label": " ( protein: PAFR, None) , ( protein: human platelet-activating factor receptor, None) , ( DNA: human platelet-activating factor receptor ( PAFR ) gene, None) , ( protein: PAFR, None) , ( RNA: PAFR transcript 2, None) , ( DNA: promoter 2, None) , ( DNA: promoter 1, None) , ( protein: PAFR, None) , ( DNA: promoters, None) , ( RNA: PAFR transcript 1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PAFR, None) , ( protein: human platelet-activating factor receptor, None) , ( DNA: human platelet-activating factor receptor ( PAFR ) gene, None) , ( protein: PAFR, None) , ( RNA: PAFR transcript 2, None) , ( DNA: promoter 2, None) , ( DNA: promoter 1, None) , ( protein: PAFR, None) , ( DNA: promoters, None) , ( RNA: PAFR transcript 1, None) " }

[]

{ "id": "1681", "sentence": "By primer extension analysis to discriminate two transcripts, we found that the levels of PAFR transcript 1 ( leukocyte-type ), but not PAFR transcript 2 ( tissue-type ), are upregulated by PAF as well as by 12-O-tetradecanoylphorbol-13-acetate ( TPA ) in the human stomach cancer cell line ( JR-St cells ) which expresses both functional PAFR transcript 1 and PAFR transcript 2 endogenously.", "label": " ( protein: PAF, None) , ( cell line: JR-St cells, None) , ( protein: PAFR, None) , ( protein: PAFR, None) , ( RNA: PAFR transcript 2, None) , ( RNA: PAFR transcript 1, None) , ( RNA: PAFR transcript 1, None) , ( RNA: PAFR transcript 2, None) , ( protein: PAFR, None) , ( protein: PAFR, None) , ( cell line: human stomach cancer cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PAF, None) , ( cell line: JR-St cells, None) , ( protein: PAFR, None) , ( protein: PAFR, None) , ( RNA: PAFR transcript 2, None) , ( RNA: PAFR transcript 1, None) , ( RNA: PAFR transcript 1, None) , ( RNA: PAFR transcript 2, None) , ( protein: PAFR, None) , ( protein: PAFR, None) , ( cell line: human stomach cancer cell line, None) " }

[]

{ "id": "1682", "sentence": "Functional analysis of the promoter 1 with a transient expression assay using chloramphenicol acetyltransferase (CAT) gene as a reporter showed that both PAF and TPA activated the promoter 1 but not the deleted promoter lacking the three consensus binding sites for NF-kappa B located from -571 bp to -459 bp.", "label": " ( protein: PAF, None) , ( DNA: promoter 1, None) , ( DNA: deleted promoter, None) , ( DNA: promoter 1, None) , ( DNA: consensus binding sites, None) , ( protein: NF-kappa B, None) , ( DNA: chloramphenicol acetyltransferase (CAT) gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PAF, None) , ( DNA: promoter 1, None) , ( DNA: deleted promoter, None) , ( DNA: promoter 1, None) , ( DNA: consensus binding sites, None) , ( protein: NF-kappa B, None) , ( DNA: chloramphenicol acetyltransferase (CAT) gene, None) " }

[]

{ "id": "1683", "sentence": "These findings suggest a molecular mechanism of positive regulation of PAFR gene expression by PAF through NF-kappa B , possibly by a phosphorylation reaction involving protein kinase C by PAF .", "label": " ( protein: PAF, None) , ( protein: NF-kappa B, None) , ( protein: PAFR, None) , ( protein: PAF, None) , ( protein: protein kinase C, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PAF, None) , ( protein: NF-kappa B, None) , ( protein: PAFR, None) , ( protein: PAF, None) , ( protein: protein kinase C, None) " }

[]

{ "id": "1684", "sentence": "One gene, two transcripts : isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjogrens' syndrome .", "label": " ( RNA: transcripts, None) , ( DNA: cDNA library, None) , ( protein: autoantigen La/SS-B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: transcripts, None) , ( DNA: cDNA library, None) , ( protein: autoantigen La/SS-B, None) " }

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{ "id": "1685", "sentence": "A cDNA library was prepared from peripheral blood lymphocytes of an autoimmune patient with primary Sjogrens' syndrome .", "label": " ( DNA: cDNA library, None) , ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: cDNA library, None) , ( cell type: lymphocytes, None) " }

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{ "id": "1686", "sentence": "The cDNA library was screened with the patients own autoimmune serum being monospecific for the nuclear autoantigen La/SS-B .", "label": " ( DNA: cDNA library, None) , ( protein: autoantigen La/SS-B, None) , ( protein: nuclear autoantigen La/SS-B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: cDNA library, None) , ( protein: autoantigen La/SS-B, None) , ( protein: nuclear autoantigen La/SS-B, None) " }

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{ "id": "1687", "sentence": "Thereby an alternative type of La mRNA was identified that differed from the known La mRNA due to an exchange of the exon 1 .", "label": " ( DNA: exon 1, None) , ( RNA: La mRNA, None) , ( RNA: La mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: exon 1, None) , ( RNA: La mRNA, None) , ( RNA: La mRNA, None) " }

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{ "id": "1688", "sentence": "Sequencing of the genomic region between the exons 1 and 2 showed that the alternative 5'-end is a part of the intron .", "label": " ( DNA: alternative 5#$%#-end, None) , ( DNA: intron, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: alternative 5#$%#-end, None) , ( DNA: intron, None) " }

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{ "id": "1689", "sentence": "In addition, the presence of an alternative promoter site , which exists within the intron downstream of the exon 1 , became evident.", "label": " ( DNA: intron, None) , ( DNA: alternative promoter site, None) , ( DNA: exon 1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: intron, None) , ( DNA: alternative promoter site, None) , ( DNA: exon 1, None) " }

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{ "id": "1690", "sentence": "In consequence, the alternative La mRNA is the result of a promoter switching combined with an alternative splicing mechanism .", "label": " ( RNA: alternative La mRNA, None) , ( RNA: La mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: alternative La mRNA, None) , ( RNA: La mRNA, None) " }

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{ "id": "1691", "sentence": "In the intron, further transcription factor binding sites, including a NF-kappa B element , were identified leading to the suggestion that the expression of the gene encoding for the nuclear autoantigen La/SS-B alters in dependence on disease conditions.", "label": " ( protein: transcription factor, None) , ( DNA: NF-kappa B element, None) , ( protein: nuclear autoantigen La/SS-B, None) , ( protein: autoantigen La/SS-B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor, None) , ( DNA: NF-kappa B element, None) , ( protein: nuclear autoantigen La/SS-B, None) , ( protein: autoantigen La/SS-B, None) " }

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{ "id": "1692", "sentence": "Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B .", "label": " ( protein: CD40, None) , ( protein: nuclear factor-kappa B, None) , ( cell type: B cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD40, None) , ( protein: nuclear factor-kappa B, None) , ( cell type: B cells, None) " }

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{ "id": "1693", "sentence": "The B cell-associated surface molecule CD40 functions to regulate B cell responses.", "label": " ( protein: CD40, None) , ( protein: B cell-associated surface molecule CD40, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD40, None) , ( protein: B cell-associated surface molecule CD40, None) " }

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{ "id": "1694", "sentence": "Cross-linking CD40 on B cells can lead to homotypic cell adhesion, IL-6 production , and, in combination with cytokines , to Ig isotype switching .", "label": " ( protein: CD40, None) , ( cell type: B cells, None) , ( protein: cytokines, None) , ( protein: IL-6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD40, None) , ( cell type: B cells, None) , ( protein: cytokines, None) , ( protein: IL-6, None) " }

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{ "id": "1695", "sentence": "Tyrosine kinase activity is increased shortly after engagement of this receptor.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1696", "sentence": "Little is known about how the very early events induced by CD40 cross-linking link to cellular responses.", "label": " ( protein: CD40, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD40, None) " }

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{ "id": "1697", "sentence": "In this study, we demonstrate that nuclear factor (NF)-kappa B and NF-kappa B-like transcription factors are activated after cross-linking CD40 on resting human tonsillar B cells and on B cell lines .", "label": " ( cell type: B cells, None) , ( protein: NF-kappa B-like transcription factors, None) , ( protein: nuclear factor (NF)-kappa B, None) , ( cell line: B cell lines, None) , ( protein: transcription factors, None) , ( cell type: human tonsillar B cells, None) , ( protein: CD40, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B cells, None) , ( protein: NF-kappa B-like transcription factors, None) , ( protein: nuclear factor (NF)-kappa B, None) , ( cell line: B cell lines, None) , ( protein: transcription factors, None) , ( cell type: human tonsillar B cells, None) , ( protein: CD40, None) " }

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{ "id": "1698", "sentence": "The activation is rapid and is mediated through a tyrosine kinase-dependent pathway .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1699", "sentence": "The complexes detected in electrophoretic mobility shift assays contain p50 , p65 ( RelA ), c-Rel , and most likely other components.", "label": " ( protein: p65, None) , ( protein: RelA, None) , ( protein: p50, None) , ( protein: c-Rel, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p65, None) , ( protein: RelA, None) , ( protein: p50, None) , ( protein: c-Rel, None) " }