Datasets:

huy-nh-2000

/

instructUIE

like 0

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{ "id": "1400", "sentence": "The TCL1 gene sequence, which, to our knowledge, shows no sequence homology with other human genes , is preferentially expressed early in T- and B- lymphocyte differentiation.", "label": " ( DNA: human genes, None) , ( DNA: TCL1 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: human genes, None) , ( DNA: TCL1 gene, None) " }

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{ "id": "1401", "sentence": "Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 ( macrophage colony-stimulating factor ) receptor promoter and binds PEBP2/CBF ( AML1 ).", "label": " ( protein: colony-stimulating factor 1, None) , ( protein: AML1, None) , ( DNA: receptor promoter, None) , ( protein: macrophage colony-stimulating factor, None) , ( protein: PEBP2/CBF, None) , ( DNA: colony-stimulating factor 1 ( macrophage colony-stimulating factor ) receptor promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: colony-stimulating factor 1, None) , ( protein: AML1, None) , ( DNA: receptor promoter, None) , ( protein: macrophage colony-stimulating factor, None) , ( protein: PEBP2/CBF, None) , ( DNA: colony-stimulating factor 1 ( macrophage colony-stimulating factor ) receptor promoter, None) " }

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{ "id": "1402", "sentence": "The receptor for the macrophage colony-stimulating factor (or colony-stimulating factor 1 [ CSF-1 ]) is expressed from different promoters in monocytic cells and placental trophoblasts .", "label": " ( protein: colony-stimulating factor 1, None) , ( cell type: monocytic cells, None) , ( protein: CSF-1, None) , ( cell type: placental trophoblasts, None) , ( protein: macrophage colony-stimulating factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: colony-stimulating factor 1, None) , ( cell type: monocytic cells, None) , ( protein: CSF-1, None) , ( cell type: placental trophoblasts, None) , ( protein: macrophage colony-stimulating factor, None) " }

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{ "id": "1403", "sentence": "We have demonstrated that the monocyte-specific expression of the CSF-1 receptor is regulated at the level of transcription by a tissue-specific promoter whose activity is stimulated by the monocyte/B-cell-specific transcription factor PU.1 (D.-E.Zhang, C.J.Hetherington, H.-M.Chen, and D.G.Tenen, Mol.Cell. Biol.14:373-381, 1994).", "label": " ( protein: PU.1, None) , ( protein: CSF-1, None) , ( protein: monocyte/B-cell-specific transcription factor, None) , ( DNA: tissue-specific promoter, None) , ( protein: CSF-1 receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PU.1, None) , ( protein: CSF-1, None) , ( protein: monocyte/B-cell-specific transcription factor, None) , ( DNA: tissue-specific promoter, None) , ( protein: CSF-1 receptor, None) " }

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{ "id": "1404", "sentence": "Here we report that the tissue specificity of this promoter is also mediated by sequences in a region II (bp -88 to - 59), which lies 10 bp upstream from the PU.1 -binding site .", "label": " ( DNA: region II, None) , ( protein: PU.1, None) , ( DNA: promoter, None) , ( DNA: PU.1 -binding site, None) , ( DNA: 10 bp upstream, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: region II, None) , ( protein: PU.1, None) , ( DNA: promoter, None) , ( DNA: PU.1 -binding site, None) , ( DNA: 10 bp upstream, None) " }

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{ "id": "1405", "sentence": "When analyzed by DNase footprinting , region II was protected preferentially in monocytic cells .", "label": " ( DNA: region II, None) , ( protein: DNase, None) , ( cell type: monocytic cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: region II, None) , ( protein: DNase, None) , ( cell type: monocytic cells, None) " }

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{ "id": "1406", "sentence": "Electrophoretic mobility shift assays confirmed that region II interacts specifically with nuclear proteins from monocytic cells .", "label": " ( cell type: monocytic cells, None) , ( protein: nuclear proteins, None) , ( DNA: region II, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytic cells, None) , ( protein: nuclear proteins, None) , ( DNA: region II, None) " }

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{ "id": "1407", "sentence": "Two gel shift complexes ( Mono A and Mono B ) were formed with separate sequence elements within this region.", "label": " ( protein: Mono B, None) , ( protein: gel shift complexes, None) , ( protein: Mono A, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Mono B, None) , ( protein: gel shift complexes, None) , ( protein: Mono A, None) " }

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{ "id": "1408", "sentence": "Competition and supershift experiments indicate that Mono B contains a member of the polyomavirus enhancer-binding protein 2/core-binding factor ( PEBP2/CBF ) family, which includes the AML1 gene product, while Mono A is a distinct complex preferentially expressed in monocytic cells .", "label": " ( protein: PEBP2/CBF, None) , ( cell type: monocytic cells, None) , ( protein: polyomavirus enhancer-binding protein 2/core-binding factor ( PEBP2/CBF ) family,, None) , ( protein: Mono B, None) , ( protein: Mono A, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PEBP2/CBF, None) , ( cell type: monocytic cells, None) , ( protein: polyomavirus enhancer-binding protein 2/core-binding factor ( PEBP2/CBF ) family,, None) , ( protein: Mono B, None) , ( protein: Mono A, None) " }

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{ "id": "1409", "sentence": "Promoter constructs with mutations in these sequence elements were no longer expressed specifically in monocytes .", "label": " ( cell type: monocytes, None) , ( DNA: Promoter constructs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytes, None) , ( DNA: Promoter constructs, None) " }

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{ "id": "1410", "sentence": "Furthermore, multimerized region II sequence elements enhanced the activity of a heterologous thymidine kinase promoter in monocytic cells but not other cell types tested.", "label": " ( cell type: monocytic cells, None) , ( DNA: region II, None) , ( DNA: heterologous thymidine kinase promoter, None) , ( DNA: multimerized region II sequence elements, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytic cells, None) , ( DNA: region II, None) , ( DNA: heterologous thymidine kinase promoter, None) , ( DNA: multimerized region II sequence elements, None) " }

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{ "id": "1411", "sentence": "These results indicate that the monocyte/B-cell-specific transcription factor PU.1 and the Mono A and Mono B protein complexes act in concert to regulate monocyte-specific transcription of the CSF-1 receptor .", "label": " ( protein: CSF-1, None) , ( protein: CSF-1 receptor, None) , ( protein: monocyte/B-cell-specific transcription factor, None) , ( protein: PU.1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CSF-1, None) , ( protein: CSF-1 receptor, None) , ( protein: monocyte/B-cell-specific transcription factor, None) , ( protein: PU.1, None) " }

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{ "id": "1412", "sentence": "Pyrrolidine dithiocarbamate , a potent inhibitor of nuclear factor kappa B ( NF-kappa B ) activation, prevents apoptosis in human promyelocytic leukemia HL-60 cells and thymocytes .", "label": " ( cell line: promyelocytic leukemia HL-60 cells, None) , ( protein: nuclear factor kappa B, None) , ( protein: NF-kappa B, None) , ( cell type: thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: promyelocytic leukemia HL-60 cells, None) , ( protein: nuclear factor kappa B, None) , ( protein: NF-kappa B, None) , ( cell type: thymocytes, None) " }

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{ "id": "1413", "sentence": "We examined the effect of pyrrolidine dithiocarbamate ( PDTC ), which potently blocks the activation of nuclear factor kappa B ( NF-kappa B ), on the induction of apoptosis by a variety of agents.", "label": " ( protein: NF-kappa B, None) , ( protein: nuclear factor kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: nuclear factor kappa B, None) " }

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{ "id": "1414", "sentence": "Treatment of a human promyelocytic leukemia cell line , HL-60 , with 10 micrograms/mL etoposide or 2 microM 1-beta-D-arabinofuranosylcytosine induced NF-kappa B activation within 1 hr and subsequently caused apoptosis within 3-4 hr.", "label": " ( protein: NF-kappa B, None) , ( cell line: HL-60, None) , ( cell line: human promyelocytic leukemia cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( cell line: HL-60, None) , ( cell line: human promyelocytic leukemia cell line, None) " }

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{ "id": "1415", "sentence": "The simultaneous addition of 50-500 microM PDTC with these agents blocked NF-kappa B activation and completely abrogated both morphologically apoptotic changes and internucleosomal DNA fragmentation for up to 6 hr.", "label": " ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) " }

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{ "id": "1416", "sentence": "However, PDTC failed to inhibit the endonuclease activity contained in the whole cell lysates.", "label": " ( protein: endonuclease, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: endonuclease, None) " }

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{ "id": "1417", "sentence": "The inhibitory effect of PDTC was also observed in etoposide -and dexamethasone-induced apoptosis in human thymocytes at a concentration of 1-10 microM.", "label": " ( cell type: thymocytes, None) , ( cell type: human thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: thymocytes, None) , ( cell type: human thymocytes, None) " }

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{ "id": "1418", "sentence": "Since PDTC has both antioxidant and metal-ion chelating activities , we tested the effects of N-acetyl-L-cysteine ( NAC ) ( antioxidant ) or o-phenanthroline ( OP ) ( metal-ion chelator ) on the induction of apoptosis .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1419", "sentence": "Pretreatment of HL-60 cells or thymocytes with 100-500 microM OP for 2 hr, but not 10-60 mM NAC , suppressed subsequent occurrence of apoptosis induced by etoposide .", "label": " ( cell type: thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: thymocytes, None) " }

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{ "id": "1420", "sentence": "These results suggest that the activation of NF-kappa B plays an important role in the apoptotic process of human hematopoietic cells .", "label": " ( protein: NF-kappa B, None) , ( cell type: human hematopoietic cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( cell type: human hematopoietic cells, None) " }

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{ "id": "1421", "sentence": "Overexpression of protein kinase C -zeta stimulates leukemic cell differentiation .", "label": " ( protein: protein kinase C -zeta, None) , ( cell type: leukemic cell, None) , ( protein: protein kinase C, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: protein kinase C -zeta, None) , ( cell type: leukemic cell, None) , ( protein: protein kinase C, None) " }

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{ "id": "1422", "sentence": "A function for protein kinase C -zeta ( PKC -zeta ), a member of the phorbol ester nonresponsive atypical protein kinase C subfamily , in modulating differentiation was examined in the leukemic U937 cell .", "label": " ( protein: protein kinase C -zeta, None) , ( protein: PKC, None) , ( protein: protein kinase C subfamily, None) , ( protein: PKC -zeta, None) , ( cell line: leukemic U937 cell, None) , ( protein: protein kinase C, None) , ( protein: protein kinase C, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: protein kinase C -zeta, None) , ( protein: PKC, None) , ( protein: protein kinase C subfamily, None) , ( protein: PKC -zeta, None) , ( cell line: leukemic U937 cell, None) , ( protein: protein kinase C, None) , ( protein: protein kinase C, None) " }

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{ "id": "1423", "sentence": "Transfected U937 cells stably overexpressing PKC-zeta displayed a longer doubling time, lower saturation density at confluency, and an increase in adherence to plastic as compared to control cells .", "label": " ( protein: PKC-zeta, None) , ( cell line: control cells, None) , ( cell line: U937 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC-zeta, None) , ( cell line: control cells, None) , ( cell line: U937 cells, None) " }

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{ "id": "1424", "sentence": "PKC-zeta cells expressed a more differentiated phenotype as assessed by changes in morphology, surface antigen expression, and lysosomal enzyme activities and were distinct from parental U937 cells stimulated to differentiate by exposure to phorbol esters .", "label": " ( protein: PKC-zeta, None) , ( protein: lysosomal enzyme, None) , ( cell line: parental U937 cells, None) , ( cell line: PKC-zeta cells, None) , ( cell line: U937 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC-zeta, None) , ( protein: lysosomal enzyme, None) , ( cell line: parental U937 cells, None) , ( cell line: PKC-zeta cells, None) , ( cell line: U937 cells, None) " }

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{ "id": "1425", "sentence": "In contrast to parental U937 cells , PKC-zeta cells constitutively expressed mRNA transcripts for c-jun and a low mobility AP-1 binding activity .", "label": " ( cell line: PKC-zeta cells, None) , ( RNA: mRNA, None) , ( RNA: mRNA transcripts, None) , ( DNA: c-jun, None) , ( protein: AP-1, None) , ( cell line: U937 cells, None) , ( protein: PKC-zeta, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: PKC-zeta cells, None) , ( RNA: mRNA, None) , ( RNA: mRNA transcripts, None) , ( DNA: c-jun, None) , ( protein: AP-1, None) , ( cell line: U937 cells, None) , ( protein: PKC-zeta, None) " }

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{ "id": "1426", "sentence": "Thus, PKC-zeta overexpression stimulates a type of phenotypic differentiation that differs significantly from maturation occurring upon activation of other PKC subfamilies induced by phorbol ester treatment .", "label": " ( protein: PKC-zeta, None) , ( protein: PKC subfamilies, None) , ( protein: PKC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC-zeta, None) , ( protein: PKC subfamilies, None) , ( protein: PKC, None) " }

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{ "id": "1427", "sentence": "Increased expression of the c-jun protooncogene and an increase in AP-1 binding activity in PKC-zeta cells provides a potential mechanism for explaining the altered differentiation status of this cell.", "label": " ( protein: AP-1, None) , ( DNA: c-jun, None) , ( cell line: PKC-zeta cells, None) , ( protein: PKC-zeta, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( DNA: c-jun, None) , ( cell line: PKC-zeta cells, None) , ( protein: PKC-zeta, None) " }

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{ "id": "1428", "sentence": "A family of serine proteases expressed exclusively in myelo- monocytic cells specifically processes the nuclear factor-kappa B subunit p65 in vitro and may impair human immunodeficiency virus replication in these cells.", "label": " ( protein: nuclear factor-kappa B subunit p65, None) , ( protein: serine proteases, None) , ( cell type: monocytic cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor-kappa B subunit p65, None) , ( protein: serine proteases, None) , ( cell type: monocytic cells, None) " }

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{ "id": "1429", "sentence": "Two groups of U937 promonocytic cells were obtained by limiting dilution cloning which differed strikingly in their ability to support human immunodeficiency virus 1 ( HIV-1 ) replication .", "label": " ( cell line: U937 promonocytic cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: U937 promonocytic cells, None) " }

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{ "id": "1430", "sentence": "\"Plus\" clones replicated the virus efficiently, whereas \"minus\" clones did not.", "label": " ( cell line: \"Plus\" clones, None) , ( cell line: \"minus\" clones, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: \"Plus\" clones, None) , ( cell line: \"minus\" clones, None) " }

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{ "id": "1431", "sentence": "We examined these clones for differences in nuclear factor (NF)-kappa B activity which might account for the observed phenomenon.", "label": " ( protein: nuclear factor (NF)-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor (NF)-kappa B, None) " }

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{ "id": "1432", "sentence": "Stimulation of plus clones liberated the classical p50-p65 complex from cytoplasmic pools, whereas minus clones produced an apparently novel, faster-migrating complex , as judged by electrophoretic mobility shift assays .", "label": " ( cell line: plus clones, None) , ( protein: p50-p65 complex, None) , ( protein: faster-migrating complex, None) , ( cell line: minus clones, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: plus clones, None) , ( protein: p50-p65 complex, None) , ( protein: faster-migrating complex, None) , ( cell line: minus clones, None) " }

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{ "id": "1433", "sentence": "It is surprising that the faster-migrating complex was composed also of p50 and p65 .", "label": " ( protein: p50, None) , ( protein: faster-migrating complex, None) , ( protein: p65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p50, None) , ( protein: faster-migrating complex, None) , ( protein: p65, None) " }

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{ "id": "1434", "sentence": "However, the p65 subunit was COOH-terminally truncated , as shown by immunoprecipitation .", "label": " ( protein: p65 subunit, None) , ( protein: p65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p65 subunit, None) , ( protein: p65, None) " }

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{ "id": "1435", "sentence": "The truncation resulted from limited proteolysis of p65 during cellular extraction which released particular lysosomal serine proteases , such as elastase , cathepsin G , and proteinase 3 .", "label": " ( protein: cathepsin G, None) , ( protein: proteinase 3, None) , ( protein: serine proteases, None) , ( protein: lysosomal serine proteases, None) , ( protein: p65, None) , ( protein: elastase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cathepsin G, None) , ( protein: proteinase 3, None) , ( protein: serine proteases, None) , ( protein: lysosomal serine proteases, None) , ( protein: p65, None) , ( protein: elastase, None) " }

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{ "id": "1436", "sentence": "These specific proteases are coordinately expressed and were present exclusively in the minus U937 clones , but not in the plus clones , as demonstrated in the case of cathepsin G .", "label": " ( cell line: plus clones, None) , ( protein: cathepsin G, None) , ( cell line: minus U937 clones, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: plus clones, None) , ( protein: cathepsin G, None) , ( cell line: minus U937 clones, None) " }

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{ "id": "1437", "sentence": "In addition, these proteases were detected in certain subclones of THP-1 and HL-60 cells and in primary monocytes , in each case correlating with the truncated from of p65 .", "label": " ( cell line: THP-1, None) , ( protein: p65, None) , ( cell line: HL-60 cells, None) , ( cell type: monocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: THP-1, None) , ( protein: p65, None) , ( cell line: HL-60 cells, None) , ( cell type: monocytes, None) " }

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{ "id": "1438", "sentence": "We demonstrate in vitro cleavage of p65 by purified elastase and cathepsin G .", "label": " ( protein: elastase, None) , ( protein: p65, None) , ( protein: cathepsin G, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: elastase, None) , ( protein: p65, None) , ( protein: cathepsin G, None) " }

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{ "id": "1439", "sentence": "It is possible that particular serine proteases may have inhibiting effects on the replication of HIV-1 in myelo- monocytic cells .", "label": " ( cell type: monocytic cells, None) , ( cell line: myelo- monocytic cells, None) , ( protein: serine proteases, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytic cells, None) , ( cell line: myelo- monocytic cells, None) , ( protein: serine proteases, None) " }

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{ "id": "1440", "sentence": "The data also demonstrate that special precautions must be taken when making extracts from myelo- monocytic cells .", "label": " ( cell line: myelo- monocytic cells, None) , ( cell type: monocytic cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: myelo- monocytic cells, None) , ( cell type: monocytic cells, None) " }

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{ "id": "1441", "sentence": "A germline TaqI restriction fragment length polymorphism in the progesterone receptor gene in ovarian carcinoma [see comments]", "label": " ( DNA: germline TaqI restriction fragment length polymorphism, None) , ( DNA: progesterone receptor gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: germline TaqI restriction fragment length polymorphism, None) , ( DNA: progesterone receptor gene, None) " }

[]

{ "id": "1442", "sentence": "Clinical outcome in ovarian carcinoma is predicted by progesterone receptor status , indicating an endocrine aspect to this disease.", "label": " ( protein: progesterone receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: progesterone receptor, None) " }

[]

{ "id": "1443", "sentence": "Peripheral leucocyte genomic DNAs were obtained from 41 patients with primary ovarian carcinoma and 83 controls from Ireland, as well as from 26 primary ovarian carcinoma patients and 101 controls in Germany.", "label": " ( DNA: Peripheral leucocyte genomic DNAs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Peripheral leucocyte genomic DNAs, None) " }

[]

{ "id": "1444", "sentence": "Southern analysis using a human progesterone receptor ( hPR ) cDNA probe identified a germline TaqI restriction fragment length polymorphism ( RFLP ) defined by two alleles : T1 , represented by a 2.7 kb fragment ; and T2 , represented by a 1.9 kb fragment and characterised by an additional TaqI restriction site with respect to T1 .", "label": " ( DNA: T1, None) , ( protein: hPR, None) , ( DNA: 1.9 kb fragment, None) , ( DNA: germline TaqI restriction fragment length polymorphism, None) , ( DNA: T1, None) , ( DNA: 2.7 kb fragment, None) , ( protein: human progesterone receptor, None) , ( DNA: human progesterone receptor ( hPR ) cDNA probe, None) , ( DNA: TaqI restriction site, None) , ( DNA: alleles, None) , ( DNA: RFLP, None) , ( protein: progesterone receptor, None) , ( DNA: T2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: T1, None) , ( protein: hPR, None) , ( DNA: 1.9 kb fragment, None) , ( DNA: germline TaqI restriction fragment length polymorphism, None) , ( DNA: T1, None) , ( DNA: 2.7 kb fragment, None) , ( protein: human progesterone receptor, None) , ( DNA: human progesterone receptor ( hPR ) cDNA probe, None) , ( DNA: TaqI restriction site, None) , ( DNA: alleles, None) , ( DNA: RFLP, None) , ( protein: progesterone receptor, None) , ( DNA: T2, None) " }

[]

{ "id": "1445", "sentence": "An over-representation of T2 in ovarian cancer patients compared with controls in the pooled Irish/German population (P < 0.025) was observed.", "label": " ( DNA: T2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: T2, None) " }

[]

{ "id": "1446", "sentence": "A difference (P < 0.02) in the distribution of the RFLP genotypes between Irish and German control populations was also observed.", "label": " ( DNA: RFLP, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: RFLP, None) " }

[]

{ "id": "1447", "sentence": "The allele distributions could not be shown to differ significantly from Hardy-Weinberg distribution in any subgroup.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1448", "sentence": "Using hPR cDNA region-specific probes , the extra TaqI restriction site was mapped to intron G of the hPR gene .", "label": " ( protein: hPR, None) , ( protein: hPR, None) , ( DNA: hPR gene, None) , ( DNA: hPR cDNA region-specific probes, None) , ( DNA: intron G, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hPR, None) , ( protein: hPR, None) , ( DNA: hPR gene, None) , ( DNA: hPR cDNA region-specific probes, None) , ( DNA: intron G, None) " }

[]

{ "id": "1449", "sentence": "OBF-1 , a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins .", "label": " ( protein: novel B cell-specific coactivator, None) , ( protein: OBF-1, None) , ( DNA: immunoglobulin promoter, None) , ( protein: octamer-binding proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: novel B cell-specific coactivator, None) , ( protein: OBF-1, None) , ( DNA: immunoglobulin promoter, None) , ( protein: octamer-binding proteins, None) " }

[]

{ "id": "1450", "sentence": "Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2 , other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity .", "label": " ( protein: B cell components, None) , ( protein: octamer-binding proteins, None) , ( DNA: immunoglobulin gene promoter, None) , ( protein: Oct-1, None) , ( protein: Oct-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: B cell components, None) , ( protein: octamer-binding proteins, None) , ( DNA: immunoglobulin gene promoter, None) , ( protein: Oct-1, None) , ( protein: Oct-2, None) " }

[]

{ "id": "1451", "sentence": "Using a genetic screen in yeast, we have isolated B cell-derived cDNAs encoding Oct-binding factor 1 ( OBF-1 ), a novel protein that specifically associates with Oct-1 and Oct-2 .", "label": " ( protein: Oct-1, None) , ( protein: Oct-2, None) , ( DNA: B cell-derived cDNAs, None) , ( protein: OBF-1, None) , ( protein: Oct-binding factor 1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-1, None) , ( protein: Oct-2, None) , ( DNA: B cell-derived cDNAs, None) , ( protein: OBF-1, None) , ( protein: Oct-binding factor 1, None) " }

[]

{ "id": "1452", "sentence": "Biochemical studies demonstrate that OBF-1 has no intrinsic DNA-binding activity and recognizes the POU domains of Oct-1 and Oct-2 , but not those of Oct-4 and Oct-6 .", "label": " ( protein: Oct-1, None) , ( protein: OBF-1, None) , ( protein: POU domains, None) , ( protein: Oct-6, None) , ( protein: Oct-4, None) , ( protein: Oct-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-1, None) , ( protein: OBF-1, None) , ( protein: POU domains, None) , ( protein: Oct-6, None) , ( protein: Oct-4, None) , ( protein: Oct-2, None) " }

[]

{ "id": "1453", "sentence": "The OBF-1 mRNA is expressed in a highly cell-specific manner, being most abundant in B cells and essentially absent in most of the other cells or tissues tested.", "label": " ( protein: OBF-1, None) , ( cell type: B cells, None) , ( RNA: OBF-1 mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: OBF-1, None) , ( cell type: B cells, None) , ( RNA: OBF-1 mRNA, None) " }

[]

{ "id": "1454", "sentence": "Furthermore, expression of OBF-1 in HeLa cells selectively stimulates the activity of a natural immunoglobulin promoter in an octamer site -dependent manner .", "label": " ( DNA: immunoglobulin promoter, None) , ( protein: OBF-1, None) , ( DNA: octamer site, None) , ( cell line: HeLa cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: immunoglobulin promoter, None) , ( protein: OBF-1, None) , ( DNA: octamer site, None) , ( cell line: HeLa cells, None) " }

[]

{ "id": "1455", "sentence": "Thus, OBF-1 has all the properties expected for a B cell-specific transcriptional coactivator protein .", "label": " ( protein: OBF-1, None) , ( protein: B cell-specific transcriptional coactivator protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: OBF-1, None) , ( protein: B cell-specific transcriptional coactivator protein, None) " }

[]

{ "id": "1456", "sentence": "Modulation of transcription factor NF kappa B activity by intracellular glutathione levels and by variations of the extracellular cysteine supply .", "label": " ( protein: transcription factor NF kappa B, None) , ( protein: NF kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor NF kappa B, None) , ( protein: NF kappa B, None) " }

[]

{ "id": "1457", "sentence": "HIV -infected individuals and SIV -infected rhesus macaques have, on the average, decreased plasma cysteine and cystine concentrations and decreased intracellular glutathione levels .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1458", "sentence": "We now show that a depletion of intracellular glutathione in a human T cell line ( Molt-4 ) inhibits the activation and nuclear translocation of the transcription factor NF kappa B , whereas incubation with increasing extracellular concentrations of cysteine inhibits the DNA-binding and transactivating activity of NF kappa B .", "label": " ( cell line: human T cell line, None) , ( protein: NF kappa B, None) , ( protein: NF kappa B, None) , ( protein: transcription factor NF kappa B, None) , ( cell line: Molt-4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: human T cell line, None) , ( protein: NF kappa B, None) , ( protein: NF kappa B, None) , ( protein: transcription factor NF kappa B, None) , ( cell line: Molt-4, None) " }

[]

{ "id": "1459", "sentence": "Because inhibition of DNA-binding activity is associated with increasing intracellular glutathione disulfide levels and GSSG can be shown to inhibit the DNA-binding activity directly in cell-free systems , our studies suggest that GSSG is a physiologically relevant inhibitor in intact cells also.", "label": " ( protein: GSSG, None) , ( protein: GSSG, None) , ( cell type: intact cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GSSG, None) , ( protein: GSSG, None) , ( cell type: intact cells, None) " }

[]

{ "id": "1460", "sentence": "NF kappa B controls many immunologically important genes , so our studies suggest that the immune system may be sensitive not only against a cysteine and glutathione deficiency but also against an excess of cysteine .", "label": " ( protein: NF kappa B, None) , ( DNA: immunologically important genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF kappa B, None) , ( DNA: immunologically important genes, None) " }

[]

{ "id": "1461", "sentence": "Two distinct signalling pathways are involved in the control of the biphasic junB transcription induced by interleukin-6 in the B cell hybridoma 7TD1 .", "label": " ( DNA: junB, None) , ( cell line: B cell hybridoma 7TD1, None) , ( protein: interleukin-6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: junB, None) , ( cell line: B cell hybridoma 7TD1, None) , ( protein: interleukin-6, None) " }

[]

{ "id": "1462", "sentence": "We have measured the level of junB mRNA in the B hybridoma cell line 7TD1 , under interleukin-6 ( IL-6 ) stimulation.", "label": " ( cell line: B hybridoma cell line 7TD1, None) , ( protein: IL-6, None) , ( RNA: junB mRNA, None) , ( protein: interleukin-6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: B hybridoma cell line 7TD1, None) , ( protein: IL-6, None) , ( RNA: junB mRNA, None) , ( protein: interleukin-6, None) " }

[]

{ "id": "1463", "sentence": "IL-6 increases junB mRNA in a biphasic fashion.", "label": " ( RNA: junB mRNA, None) , ( protein: IL-6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: junB mRNA, None) , ( protein: IL-6, None) " }

[]

{ "id": "1464", "sentence": "The first early-induced peak was transient and likely corresponds to the well documented typical junB mRNA , stimulated in response to numerous growth factors , including IL-6 .", "label": " ( protein: IL-6, None) , ( protein: growth factors, None) , ( RNA: junB mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-6, None) , ( protein: growth factors, None) , ( RNA: junB mRNA, None) " }

[]

{ "id": "1465", "sentence": "At variance, the second peak which has never been reported previously, lasted several hours.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1466", "sentence": "As a consequence of its effect on junB mRNA , IL-6 stimulated, in a biphasic fashion, the nuclear accumulation of the JunB protein .", "label": " ( RNA: junB mRNA, None) , ( protein: IL-6, None) , ( protein: JunB protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: junB mRNA, None) , ( protein: IL-6, None) , ( protein: JunB protein, None) " }

[]

{ "id": "1467", "sentence": "In this study, we demonstrated that IL-6 regulation occurred exclusively at the transcriptional level and that the bimodal increase of junB mRNA and JunB protein can be accounted for by a biphasic stimulation of junB transcription .", "label": " ( DNA: junB, None) , ( protein: IL-6, None) , ( RNA: junB mRNA, None) , ( protein: JunB protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: junB, None) , ( protein: IL-6, None) , ( RNA: junB mRNA, None) , ( protein: JunB protein, None) " }

[]

{ "id": "1468", "sentence": "Furthermore, our data point to two major differences between the mechanism of control of the early and the late IL-6 -induced junB transcription waves .", "label": " ( DNA: junB, None) , ( protein: IL-6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: junB, None) , ( protein: IL-6, None) " }

[]

{ "id": "1469", "sentence": "First, cycloheximide strongly potentiated the transcription of the second wave, whereas it failed to affect the early-induced burst.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1470", "sentence": "Second, tyrphostin , a tyrosine kinase inhibitor , impaired the expression of the first but not the second junB mRNA peak .", "label": " ( RNA: junB mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: junB mRNA, None) " }

[]

{ "id": "1471", "sentence": "Conversely, genistein , another tyrosine kinase inhibitor , totally abolished the expression of the second peak of junB mRNA whereas it did not affect the expression of the first peak.", "label": " ( RNA: junB mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: junB mRNA, None) " }

[]

{ "id": "1472", "sentence": "Altogether these data indicate that, in 7TD1 cells , IL-6 controls junB transcription in a biphasic fashion by means of two separate transduction pathways .", "label": " ( DNA: junB, None) , ( protein: IL-6, None) , ( cell line: 7TD1 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: junB, None) , ( protein: IL-6, None) , ( cell line: 7TD1 cells, None) " }

[]

{ "id": "1473", "sentence": "A newly established megakaryoblastic/erythroid cell line that differentiates to red cells in the presence of erythropoietin and produces platelet-like particles .", "label": " ( cell type: platelet-like particles, None) , ( protein: erythropoietin, None) , ( cell line: megakaryoblastic/erythroid cell line, None) , ( cell type: red cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: platelet-like particles, None) , ( protein: erythropoietin, None) , ( cell line: megakaryoblastic/erythroid cell line, None) , ( cell type: red cells, None) " }

[]

{ "id": "1474", "sentence": "In August, 1992, we established a leukemic cell line ( NS-Meg ) from a patient in megakaryoblastic transformation of Philadelphia chromosome-positive chronic myeloid leukemia .", "label": " ( cell line: leukemic cell line, None) , ( cell line: NS-Meg, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: leukemic cell line, None) , ( cell line: NS-Meg, None) " }

[]

{ "id": "1475", "sentence": "The NS-Meg cells were positive for alpha-naphthyl acetate esterase and periodic acid-Schiff (PAS) staining and for surface CD4 , CD7 , CD13 , CD34 , CD41a , and glycophorin A antigens .", "label": " ( protein: CD41a, None) , ( protein: CD34, None) , ( protein: glycophorin A antigens, None) , ( cell line: NS-Meg cells, None) , ( protein: CD4, None) , ( protein: alpha-naphthyl acetate esterase, None) , ( protein: CD13, None) , ( protein: CD7, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD41a, None) , ( protein: CD34, None) , ( protein: glycophorin A antigens, None) , ( cell line: NS-Meg cells, None) , ( protein: CD4, None) , ( protein: alpha-naphthyl acetate esterase, None) , ( protein: CD13, None) , ( protein: CD7, None) " }

[]

{ "id": "1476", "sentence": "Ultrastructurally, the cells had alpha-granules , demarcation membranes , and platelet peroxidase activity .", "label": " ( protein: platelet peroxidase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: platelet peroxidase, None) " }

[]

{ "id": "1477", "sentence": "The NS-Meg cells spontaneously produced platelet-like particles which contained alpha-granules , mitochondria and dense bodies , strongly suggesting platelet production .", "label": " ( cell line: NS-Meg cells, None) , ( cell type: platelet-like particles, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: NS-Meg cells, None) , ( cell type: platelet-like particles, None) " }

[]

{ "id": "1478", "sentence": "Erythropoietin ( Epo ), granulocyte/macrophage colony stimulating factor ( GM-CSF ), and interleukin 3 ( IL-3 ) promoted the growth of NS-Meg cells .", "label": " ( protein: Epo, None) , ( protein: GM-CSF, None) , ( protein: interleukin 3, None) , ( protein: Erythropoietin, None) , ( cell line: NS-Meg cells, None) , ( protein: IL-3, None) , ( protein: granulocyte/macrophage colony stimulating factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Epo, None) , ( protein: GM-CSF, None) , ( protein: interleukin 3, None) , ( protein: Erythropoietin, None) , ( cell line: NS-Meg cells, None) , ( protein: IL-3, None) , ( protein: granulocyte/macrophage colony stimulating factor, None) " }

[]

{ "id": "1479", "sentence": "Phorbol-12-myristate-13-acetate increased the expression of both CD41a and CD61 antigens.", "label": " ( protein: CD41a, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD41a, None) " }

[]

{ "id": "1480", "sentence": "Ten-day exposure to Epo induced mature erythroblasts and red cells .", "label": " ( protein: Epo, None) , ( cell type: red cells, None) , ( cell type: mature erythroblasts, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Epo, None) , ( cell type: red cells, None) , ( cell type: mature erythroblasts, None) " }

[]

{ "id": "1481", "sentence": "These benzidine-positive cells were positive for hemoglobin F staining .", "label": " ( cell line: benzidine-positive cells, None) , ( protein: hemoglobin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: benzidine-positive cells, None) , ( protein: hemoglobin, None) " }

[]

{ "id": "1482", "sentence": "Untreated NS-Meg cells expressed mRNA for the Epo receptor ( EpoR ), for GATA-1 , and for alpha 1 , alpha 2 and gamma globin genes .", "label": " ( protein: GATA-1, None) , ( RNA: mRNA, None) , ( protein: EpoR, None) , ( protein: Epo receptor, None) , ( cell line: NS-Meg cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA-1, None) , ( RNA: mRNA, None) , ( protein: EpoR, None) , ( protein: Epo receptor, None) , ( cell line: NS-Meg cells, None) " }

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{ "id": "1483", "sentence": "These results indicate that NS-Meg cells undergo terminal differentiation of both megakaryocytic and erythroid lineages .", "label": " ( cell line: NS-Meg cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: NS-Meg cells, None) " }

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{ "id": "1484", "sentence": "This cell line should be a very useful tool for the investigation of both megakaryocytic and erythroid maturation .", "label": " ( cell line: cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: cell line, None) " }

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{ "id": "1485", "sentence": "Differential regulation of proto-oncogenes c-jun and c-fos in T lymphocytes activated through CD28 .", "label": " ( DNA: c-fos, None) , ( protein: CD28, None) , ( cell type: T lymphocytes, None) , ( DNA: proto-oncogenes, None) , ( DNA: c-jun, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: c-fos, None) , ( protein: CD28, None) , ( cell type: T lymphocytes, None) , ( DNA: proto-oncogenes, None) , ( DNA: c-jun, None) " }

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{ "id": "1486", "sentence": "The T cell surface molecule CD28 binds to ligands on accessory cells and APCs , playing an important costimulatory role in the response of T cells to Ags .", "label": " ( protein: T cell surface molecule, None) , ( protein: CD28, None) , ( cell type: T cells, None) , ( cell type: APCs, None) , ( protein: Ags, None) , ( cell type: accessory cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: T cell surface molecule, None) , ( protein: CD28, None) , ( cell type: T cells, None) , ( cell type: APCs, None) , ( protein: Ags, None) , ( cell type: accessory cells, None) " }

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{ "id": "1487", "sentence": "Our knowledge of the intracellular signaling pathways coupled to this receptor is incomplete.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1488", "sentence": "In addition to activation of phospholipase C gamma 1 , ligation of this receptor also seems to activate a calcium -independent , CD28 -specific pathway .", "label": " ( protein: CD28, None) , ( protein: phospholipase C gamma 1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD28, None) , ( protein: phospholipase C gamma 1, None) " }

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{ "id": "1489", "sentence": "In this paper, we report that cross-linking of CD28 (but not CD2 , CD5 , LFA-1 , or CD7 ) leads to an elevation of c-jun mRNA , with only minimal activation of c-fos expression .", "label": " ( DNA: c-fos, None) , ( DNA: c-jun, None) , ( protein: CD28, None) , ( RNA: c-jun mRNA, None) , ( protein: CD2, None) , ( protein: CD7, None) , ( protein: CD5, None) , ( protein: LFA-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: c-fos, None) , ( DNA: c-jun, None) , ( protein: CD28, None) , ( RNA: c-jun mRNA, None) , ( protein: CD2, None) , ( protein: CD7, None) , ( protein: CD5, None) , ( protein: LFA-1, None) " }

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{ "id": "1490", "sentence": "CD28 -dependent induction of c-jun expression requires protein tyrosine kinase activity , but does not depend on activation of a phorbol ester -responsive protein kinase C or elevation of cytosolic calcium .", "label": " ( protein: protein tyrosine kinase, None) , ( DNA: c-jun, None) , ( protein: phorbol ester -responsive protein kinase C, None) , ( protein: CD28, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: protein tyrosine kinase, None) , ( DNA: c-jun, None) , ( protein: phorbol ester -responsive protein kinase C, None) , ( protein: CD28, None) " }

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{ "id": "1491", "sentence": "Furthermore, CD28 -dependent elevation of c-jun mRNA does not appear to be mediated at the level of mRNA stability .", "label": " ( protein: CD28, None) , ( DNA: c-jun, None) , ( RNA: c-jun mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD28, None) , ( DNA: c-jun, None) , ( RNA: c-jun mRNA, None) " }

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{ "id": "1492", "sentence": "A mechanism is suggested whereby expression of c-jun and junB , in the absence of members of the fos family , can prevent inappropriate activation of T cells caused by ligation of CD28 in the absence of a specific antigenic stimulus .", "label": " ( cell type: T cells, None) , ( DNA: c-jun, None) , ( DNA: fos family, None) , ( protein: CD28, None) , ( DNA: junB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( DNA: c-jun, None) , ( DNA: fos family, None) , ( protein: CD28, None) , ( DNA: junB, None) " }

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{ "id": "1493", "sentence": "Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVsmmPBj14 .", "label": " ( protein: nuclear factor kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor kappa B, None) " }

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{ "id": "1494", "sentence": "Infection with a variant of simian immunodeficiency virus , SIVsmmPBj14 , leads to severe acute disease in macaques .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1495", "sentence": "This study was designed to investigate the functional significance of previously described mutations in the viral long terminal repeat ( LTR ) and to elucidate their contribution to the unique phenotype of SIVsmmPBj14 .", "label": " ( DNA: LTR, None) , ( DNA: viral long terminal repeat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LTR, None) , ( DNA: viral long terminal repeat, None) " }

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{ "id": "1496", "sentence": "LTR -directed transcription was measured by using luciferase reporter constructs that were transiently transfected into cultured cells .", "label": " ( cell line: cultured cells, None) , ( DNA: luciferase reporter constructs, None) , ( DNA: LTR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: cultured cells, None) , ( DNA: luciferase reporter constructs, None) , ( DNA: LTR, None) " }

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{ "id": "1497", "sentence": "In a wide range of cell types, the basal transcriptional activity of the LTR from SIVsmmPBj14 was found to be 2- to 4.5-fold higher than that of an LTR from a non-acutely pathogenic strain.", "label": " ( DNA: LTR, None) , ( DNA: LTR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LTR, None) , ( DNA: LTR, None) " }

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{ "id": "1498", "sentence": "These LTRs differ by five point mutations and a 22-bp duplication in SIVsmmPBj14 , which includes a nuclear factor kappa B ( NF kappa B ) site .", "label": " ( DNA: nuclear factor kappa B ( NF kappa B ) site, None) , ( DNA: 22-bp duplication, None) , ( DNA: LTRs, None) , ( protein: nuclear factor kappa B, None) , ( protein: NF kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: nuclear factor kappa B ( NF kappa B ) site, None) , ( DNA: 22-bp duplication, None) , ( DNA: LTRs, None) , ( protein: nuclear factor kappa B, None) , ( protein: NF kappa B, None) " }

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{ "id": "1499", "sentence": "Transcriptional differences between these LTRs were further enhanced by two- to threefold upon treatment of cells with phorbol ester or tumor necrosis factor alpha or by cotransfection with plasmids expressing NF kappa B subunits.", "label": " ( DNA: plasmids, None) , ( protein: NF kappa B, None) , ( protein: tumor necrosis factor alpha, None) , ( DNA: LTRs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: plasmids, None) , ( protein: NF kappa B, None) , ( protein: tumor necrosis factor alpha, None) , ( DNA: LTRs, None) " }