Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "1200", "sentence": "Protein kinase C is not a downstream effector of p21ras in activated T cells .", "label": " ( cell type: activated T cells, None) , ( DNA: p21ras, None) , ( protein: Protein kinase C, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: activated T cells, None) , ( DNA: p21ras, None) , ( protein: Protein kinase C, None) " }

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{ "id": "1201", "sentence": "The aim of this present study was to investigate the role of protein kinase C ( PKC ), downstream of p21ras , in activating interleukin-2 (IL-2) gene expression .", "label": " ( protein: protein kinase C, None) , ( DNA: interleukin-2 (IL-2) gene, None) , ( DNA: p21ras, None) , ( protein: PKC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: protein kinase C, None) , ( DNA: interleukin-2 (IL-2) gene, None) , ( DNA: p21ras, None) , ( protein: PKC, None) " }

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{ "id": "1202", "sentence": "It has been reported that PKC is an effector of p21ras in T cells .", "label": " ( cell type: T cells, None) , ( protein: effector, None) , ( DNA: p21ras, None) , ( protein: PKC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: effector, None) , ( DNA: p21ras, None) , ( protein: PKC, None) " }

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{ "id": "1203", "sentence": "Data is presented, using the potent and selective PKC inhibitor Ro 31-8425 and transient expression of a constitutively active ras mutant, which clearly shows that PKC is not downstream of p21ras in the induction of NF-AT and AP-1 transcriptional activity and in the expression of IL-2 in human Jurkat T cells .", "label": " ( protein: AP-1, None) , ( protein: PKC, None) , ( protein: PKC, None) , ( cell line: human Jurkat T cells, None) , ( DNA: p21ras, None) , ( protein: IL-2, None) , ( protein: NF-AT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( protein: PKC, None) , ( protein: PKC, None) , ( cell line: human Jurkat T cells, None) , ( DNA: p21ras, None) , ( protein: IL-2, None) , ( protein: NF-AT, None) " }

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{ "id": "1204", "sentence": "Reporter gene experiments demonstrated that NF-kappa B transcriptional activity is not affected by expression of activated p21ras .", "label": " ( protein: NF-kappa B, None) , ( DNA: p21ras, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( DNA: p21ras, None) " }

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{ "id": "1205", "sentence": "The signaling pathways involving PKC activation , calcium mobilization and ras activation combine to provide the necessary components for production of IL-2 during T cell activation .", "label": " ( protein: ras, None) , ( protein: PKC, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ras, None) , ( protein: PKC, None) , ( protein: IL-2, None) " }

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{ "id": "1206", "sentence": "The C-terminus of the B cell activator Oct-2 functions as an activation domain in yeast .", "label": " ( protein: B cell activator, None) , ( protein: Oct-2, None) , ( protein: activation domain, None) , ( protein: C-terminus, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: B cell activator, None) , ( protein: Oct-2, None) , ( protein: activation domain, None) , ( protein: C-terminus, None) " }

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{ "id": "1207", "sentence": "Oct-1 and Oct-2 are human transcriptional activators that bind to the same DNA element but activate distinct sets of genes.", "label": " ( protein: Oct-1, None) , ( protein: transcriptional activators, None) , ( protein: Oct-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-1, None) , ( protein: transcriptional activators, None) , ( protein: Oct-2, None) " }

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{ "id": "1208", "sentence": "We expressed these factors in S. cerevisiae and observed greater than 5-fold stimulation of a lacZ reporter gene only with Oct-2 .", "label": " ( protein: Oct-2, None) , ( DNA: lacZ reporter gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-2, None) , ( DNA: lacZ reporter gene, None) " }

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{ "id": "1209", "sentence": "Transfer of the Oct-2 C-terminal domain onto either Oct-1 ( Oct1.2 ) or a nonactivating DNA-binding domain from GAL4 created activators capable of greater than 15 and 10-fold stimulation of activity, respectively.", "label": " ( protein: Oct1.2, None) , ( protein: Oct-2, None) , ( protein: Oct-2 C-terminal domain, None) , ( protein: GAL4, None) , ( protein: nonactivating DNA-binding domain, None) , ( protein: Oct-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct1.2, None) , ( protein: Oct-2, None) , ( protein: Oct-2 C-terminal domain, None) , ( protein: GAL4, None) , ( protein: nonactivating DNA-binding domain, None) , ( protein: Oct-1, None) " }

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{ "id": "1210", "sentence": "Thus, the C-terminus of Oct-2 is sufficient to confer activation potential to nonactive DNA-binding fragments in yeast .", "label": " ( DNA: DNA-binding fragments, None) , ( protein: Oct-2, None) , ( protein: C-terminus, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: DNA-binding fragments, None) , ( protein: Oct-2, None) , ( protein: C-terminus, None) " }

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{ "id": "1211", "sentence": "Glucocorticoid-induced apoptosis of lymphoid cells .", "label": " ( cell type: lymphoid cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphoid cells, None) " }

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{ "id": "1212", "sentence": "The induction of cell death in lymphoid cells by glucocorticoids is one of the earliest and most thoroughly studied models of apoptosis .", "label": " ( cell type: lymphoid cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphoid cells, None) " }

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{ "id": "1213", "sentence": "Although the exact mechanism by which apoptosis occurs in lymphocytes is unknown many biochemical and molecular changes have been shown to occur in these cells in response to glucocorticoids .", "label": " ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphocytes, None) " }

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{ "id": "1214", "sentence": "The role of chromatin degradation and endonucleases in the apoptotic process has been closely studied, as well as the involvement of several oncogenes in glucocorticoid -induced cell lysis .", "label": " ( protein: endonucleases, None) , ( DNA: chromatin, None) , ( DNA: oncogenes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: endonucleases, None) , ( DNA: chromatin, None) , ( DNA: oncogenes, None) " }

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{ "id": "1215", "sentence": "In addition, the clinical importance of glucocorticoid -induced apoptosis in the treatment of lymphoid neoplasms has recently received increased attention.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1216", "sentence": "Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes .", "label": " ( protein: Interleukin-2, None) , ( cell type: human T lymphocytes, None) , ( cell type: lymphocytes, None) , ( protein: stat3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Interleukin-2, None) , ( cell type: human T lymphocytes, None) , ( cell type: lymphocytes, None) , ( protein: stat3, None) " }

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{ "id": "1217", "sentence": "An early biochemical event associated with T cell activation through the interleukin-2 receptor ( IL-2R ) is tyrosine phosphorylation of several intracellular substrates .", "label": " ( protein: interleukin-2 receptor, None) , ( protein: IL-2R, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin-2 receptor, None) , ( protein: IL-2R, None) " }

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{ "id": "1218", "sentence": "The exact mechanism by which IL-2 regulates transcription of different genes is presently unknown.", "label": " ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) " }

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{ "id": "1219", "sentence": "Here, we report that stimulation through the IL-2R induced tyrosine phosphorylation and subsequent nuclear translocation of stat3 , a newly identified member of the signal transducers and activators of transcription (STAT) family of proteins.", "label": " ( protein: stat3, None) , ( protein: IL-2R, None) , ( protein: signal transducers and activators of transcription (STAT) family, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: stat3, None) , ( protein: IL-2R, None) , ( protein: signal transducers and activators of transcription (STAT) family, None) " }

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{ "id": "1220", "sentence": "In contrast, stat1 proteins were not tyrosine phosphorylated after IL-2 ligation , whereas tyrosine -phosphorylated stat1 proteins ( 91 and 84 kDa proteins ) were translocated to the nucleus following interferon-gamma treatment of HeLa cells .", "label": " ( protein: interferon-gamma, None) , ( cell line: HeLa cells, None) , ( protein: tyrosine -phosphorylated stat1 proteins, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interferon-gamma, None) , ( cell line: HeLa cells, None) , ( protein: tyrosine -phosphorylated stat1 proteins, None) , ( protein: IL-2, None) " }

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{ "id": "1221", "sentence": "Apart from stat3 , another cytoplasmic protein was tyrosine phosphorylated and subsequently translocated to the nucleus in response to IL-2 .", "label": " ( protein: cytoplasmic protein, None) , ( protein: IL-2, None) , ( protein: stat3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytoplasmic protein, None) , ( protein: IL-2, None) , ( protein: stat3, None) " }

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{ "id": "1222", "sentence": "This protein had an apparent molecular mass of 84 kDa and was not recognized by stat3 or stat1 mAb or antisera .", "label": " ( protein: stat1 mAb, None) , ( protein: 84 kDa, None) , ( protein: stat3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: stat1 mAb, None) , ( protein: 84 kDa, None) , ( protein: stat3, None) " }

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{ "id": "1223", "sentence": "Since IL-2 induced nuclear translocation of the 84 kDa protein and stat3 followed identical kinetics, p84 is a candidate for a new, yet undefined, member of the STAT family.", "label": " ( protein: stat3, None) , ( protein: 84 kDa protein, None) , ( protein: IL-2, None) , ( protein: p84, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: stat3, None) , ( protein: 84 kDa protein, None) , ( protein: IL-2, None) , ( protein: p84, None) " }

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{ "id": "1224", "sentence": "Taken together, we report that IL-2 induces tyrosine phosphorylation and subsequent nuclear translocation of stat3 and an as yet undefined 84-kDa protein in antigen-specific human T cell lines .", "label": " ( protein: 84-kDa protein, None) , ( protein: IL-2, None) , ( cell line: antigen-specific human T cell lines, None) , ( protein: stat3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: 84-kDa protein, None) , ( protein: IL-2, None) , ( cell line: antigen-specific human T cell lines, None) , ( protein: stat3, None) " }

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{ "id": "1225", "sentence": "Human T-cell leukemia virus type I Tax activation of NF-kappa B /Rel involves phosphorylation and degradation of I kappa B alpha and RelA ( p65 )-mediated induction of the c-rel gene .", "label": " ( protein: Tax, None) , ( protein: I kappa B alpha, None) , ( protein: NF-kappa B /Rel, None) , ( DNA: c-rel gene, None) , ( protein: p65, None) , ( protein: NF-kappa B, None) , ( protein: RelA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tax, None) , ( protein: I kappa B alpha, None) , ( protein: NF-kappa B /Rel, None) , ( DNA: c-rel gene, None) , ( protein: p65, None) , ( protein: NF-kappa B, None) , ( protein: RelA, None) " }

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{ "id": "1226", "sentence": "The tax gene product of human T-cell leukemia virus type I ( HTLV-I ) is a potent transcriptional activator that both stimulates viral gene expression and activates an array of cellular genes involved in T-cell growth .", "label": " ( protein: transcriptional activator, None) , ( cell type: T-cell, None) , ( DNA: cellular genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcriptional activator, None) , ( cell type: T-cell, None) , ( DNA: cellular genes, None) " }

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{ "id": "1227", "sentence": "Tax acts indirectly by inducing or modifying the action of various host transcription factors , including members of the NF-kappa B /Rel family of enhancer-binding proteins .", "label": " ( protein: NF-kappa B /Rel family, None) , ( protein: enhancer-binding proteins, None) , ( protein: transcription factors, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B /Rel family, None) , ( protein: enhancer-binding proteins, None) , ( protein: transcription factors, None) , ( protein: NF-kappa B, None) " }

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{ "id": "1228", "sentence": "In resting T cells , many of these NF-kappa B /Rel factors are sequestered in the cytoplasm by various ankyrin-rich inhibitory proteins , including I kappa B alpha .", "label": " ( protein: NF-kappa B, None) , ( protein: ankyrin-rich inhibitory proteins, None) , ( cell type: resting T cells, None) , ( protein: NF-kappa B /Rel factors, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: ankyrin-rich inhibitory proteins, None) , ( cell type: resting T cells, None) , ( protein: NF-kappa B /Rel factors, None) , ( protein: I kappa B alpha, None) " }

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{ "id": "1229", "sentence": "HTLV-I Tax expression leads to the constitutive nuclear expression of biologically active NF-kappa B and c-Rel complexes ; however, the biochemical mechanism (s) underlying this response remains poorly understood.", "label": " ( protein: HTLV-I Tax, None) , ( protein: c-Rel complexes, None) , ( protein: Tax, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HTLV-I Tax, None) , ( protein: c-Rel complexes, None) , ( protein: Tax, None) , ( protein: NF-kappa B, None) " }

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{ "id": "1230", "sentence": "In this study, we demonstrate that Tax -stimulated nuclear expression of NF-kappa B in both HTLV-I -infected and Tax -transfected human T cells is associated with the phosphorylation and rapid proteolytic degradation of I kappa B alpha .", "label": " ( protein: Tax, None) , ( protein: Tax, None) , ( protein: NF-kappa B, None) , ( protein: I kappa B alpha, None) , ( cell line: HTLV-I -infected and Tax -transfected human T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tax, None) , ( protein: Tax, None) , ( protein: NF-kappa B, None) , ( protein: I kappa B alpha, None) , ( cell line: HTLV-I -infected and Tax -transfected human T cells, None) " }

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{ "id": "1231", "sentence": "In contrast to prior in vitro studies, at least a fraction of the phosphorylated form of I kappa B alpha remains physically associated with the NF-kappa B complex in vivo but is subject to rapid degradation, thereby promoting the nuclear translocation of the active NF-kappa B complex .", "label": " ( protein: NF-kappa B complex, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B complex, None) , ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B complex, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B complex, None) , ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) " }

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{ "id": "1232", "sentence": "We further demonstrate that Tax induction of nuclear c-Rel expression is activated by the RelA ( p65 ) subunit of NF-kappa B , which activates transcription of the c-rel gene through an intrinsic kappa B enhancer element .", "label": " ( protein: RelA, None) , ( protein: p65, None) , ( DNA: kappa B enhancer element, None) , ( DNA: c-rel gene, None) , ( protein: NF-kappa B, None) , ( protein: c-Rel, None) , ( protein: Tax, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RelA, None) , ( protein: p65, None) , ( DNA: kappa B enhancer element, None) , ( DNA: c-rel gene, None) , ( protein: NF-kappa B, None) , ( protein: c-Rel, None) , ( protein: Tax, None) " }

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{ "id": "1233", "sentence": "In normal cells, the subsequent accumulation of nuclear c-Rel acts to inhibit its own continued production, indicating the presence of an autoregulatory loop .", "label": " ( protein: nuclear c-Rel, None) , ( protein: c-Rel, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear c-Rel, None) , ( protein: c-Rel, None) " }

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{ "id": "1234", "sentence": "(ABSTRACT TRUNCATED AT 250 WORDS)", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1235", "sentence": "Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.", "label": " ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) " }

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{ "id": "1236", "sentence": "The activation of nuclear factor kappa B ( NF-kappa B ) in intact cells is mechanistically not well understood.", "label": " ( protein: nuclear factor kappa B, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor kappa B, None) , ( protein: NF-kappa B, None) " }

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{ "id": "1237", "sentence": "Therefore we investigated the modifications imposed on NF-kappa B /I kappa B components following stimulation and show that the final step of NF-kappa B induction in vivo involves phosphorylation of several members of the NF-kappa B /I kappa B protein families .", "label": " ( protein: NF-kappa B /I kappa B components, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B /I kappa B protein families, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B /I kappa B components, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B /I kappa B protein families, None) " }

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{ "id": "1238", "sentence": "In HeLa cells as well as in B cells , TNF-alpha rapidly induced nuclear translocation primarily of p50-p65 , but not of c-rel .", "label": " ( protein: c-rel, None) , ( protein: p50-p65, None) , ( cell line: HeLa cells, None) , ( cell type: B cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c-rel, None) , ( protein: p50-p65, None) , ( cell line: HeLa cells, None) , ( cell type: B cells, None) " }

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{ "id": "1239", "sentence": "Both NF-kappa B precursors and I kappa B alpha became strongly phosphorylated with the same kinetics.", "label": " ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) " }

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{ "id": "1240", "sentence": "In addition to the inducible phosphorylation after stimulation, B lymphocytes containing constitutive nuclear NF-kappa B revealed constitutively phosphorylated p65 and I kappa B alpha .", "label": " ( protein: NF-kappa B, None) , ( cell type: lymphocytes, None) , ( cell type: B lymphocytes, None) , ( protein: I kappa B alpha, None) , ( protein: p65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( cell type: lymphocytes, None) , ( cell type: B lymphocytes, None) , ( protein: I kappa B alpha, None) , ( protein: p65, None) " }

[]

{ "id": "1241", "sentence": "Phosphorylation was accompanied by induced processing of the precursors p100 and p105 and by degradation of I kappa B alpha .", "label": " ( protein: p105, None) , ( protein: I kappa B alpha, None) , ( protein: p100, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p105, None) , ( protein: I kappa B alpha, None) , ( protein: p100, None) " }

[]

{ "id": "1242", "sentence": "As an in vitro model we show that phosphorylation of p105 impedes its ability to interact with NF-kappa B , as has been shown before for I kappa B alpha .", "label": " ( protein: NF-kappa B, None) , ( protein: I kappa B alpha, None) , ( protein: p105, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: I kappa B alpha, None) , ( protein: p105, None) " }

[]

{ "id": "1243", "sentence": "Surprisingly, even p65 , but not c-rel , was phosphorylated after induction in vivo, suggesting that TNF-alpha selectively activates only specific NF-kappa B heteromers and that modifications regulate not only I kappa B molecules but also NF-kappa B molecules.", "label": " ( protein: TNF-alpha, None) , ( protein: NF-kappa B, None) , ( protein: I kappa B, None) , ( protein: c-rel, None) , ( protein: p65, None) , ( protein: I kappa B molecules, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF-alpha, None) , ( protein: NF-kappa B, None) , ( protein: I kappa B, None) , ( protein: c-rel, None) , ( protein: p65, None) , ( protein: I kappa B molecules, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "1244", "sentence": "In fact, cellular NF-kappa B activity was phosphorylation-dependent and the DNA binding activity of p65 -containing NF-kappa B was enhanced by phosphorylation in vitro.", "label": " ( protein: p65 -containing NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: p65, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p65 -containing NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: p65, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "1245", "sentence": "Furthermore, we found that the induction by hydrogen peroxide of NF-kappa B translocation to the nucleus , which is assumed to be triggered by reactive oxygen intermediates , also coincided with incorporation of phosphate into the same subunits that were modified after stimulation by TNF-alpha .", "label": " ( protein: TNF-alpha, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF-alpha, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "1246", "sentence": "Thus, phosphorylation appears to be a general mechanism for activation of NF-kappa B in vivo.", "label": " ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) " }

[]

{ "id": "1247", "sentence": "Treatment of HL60 cells with various combinations of retinoids and 1 alpha,25 dihydroxyvitamin D3 results in differentiation towards neutrophils or monocytes or a failure to differentiate and apoptosis .", "label": " ( cell type: monocytes, None) , ( cell type: neutrophils, None) , ( cell line: HL60 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytes, None) , ( cell type: neutrophils, None) , ( cell line: HL60 cells, None) " }

[]

{ "id": "1248", "sentence": "It is well documented that treatment of serum-grown HL60 cells with 10(-7) M all-trans retinoic acid ( all-trans RA ) induces neutrophil differentiation , whereas treatment with 10(-7) M 1 alpha,25 dihydroxyvitamin D3 ( D3 ) induces differentiation towards monocytes .", "label": " ( cell type: monocytes, None) , ( cell line: serum-grown HL60 cells, None) , ( cell line: HL60 cells, None) , ( cell type: neutrophil, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytes, None) , ( cell line: serum-grown HL60 cells, None) , ( cell line: HL60 cells, None) , ( cell type: neutrophil, None) " }

[]

{ "id": "1249", "sentence": "In recent investigations, using serum-free grown HL60 cells , we observed that all-trans RA , at 10(-7) M, did not induce neutrophil differentiation and that all-trans RA , at 10(-8) M, reduced the D3 concentration required for monocyte differentiation to 5 x 10(-9) M.", "label": " ( cell line: serum-free grown HL60 cells, None) , ( cell line: HL60 cells, None) , ( cell type: monocyte, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: serum-free grown HL60 cells, None) , ( cell line: HL60 cells, None) , ( cell type: monocyte, None) " }

[]

{ "id": "1250", "sentence": "In this study, co-operative interactions between all-trans and 9-cis RA and D3 which promote neutrophil and monocyte differentiation of HL60 cells have been analysed in detail.", "label": " ( cell line: HL60 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL60 cells, None) " }

[]

{ "id": "1251", "sentence": "Treatment of serum-free grown HL60 cells with 5 x 10(-7) M all-trans RA or 9-cis RA resulted in sub-optimal neutrophil differentiation (up to 25% mature cells).", "label": " ( cell line: HL60 cells, None) , ( cell line: serum-free grown HL60 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL60 cells, None) , ( cell line: serum-free grown HL60 cells, None) " }

[]

{ "id": "1252", "sentence": "As shown for all-trans RA , 9-cis RA cooperated with D3 to promote monocyte differentiation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1253", "sentence": "Culture of HL60 cells in 5 x 10(-7) M 9-cis RA together with a wide range of concentrations of D3 resulted in promotion of neutrophil differentiation at 10(-15)-10(-12) D3 , a failure to differentiate and apoptosis at 10(-11)-10(-10) M D3 , followed by co-operativity between 9-cis RA and 5 x 10(-9) M D3 in inducing monocyte differentiation in the absence of neutrophil differentiation .", "label": " ( cell line: HL60 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL60 cells, None) " }

[]

{ "id": "1254", "sentence": "Similar results were obtained when HL60 cells were treated with 5 x 10(-7) all-trans RA together with a wide range of concentrations of D3 .", "label": " ( cell line: HL60 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL60 cells, None) " }

[]

{ "id": "1255", "sentence": "Cross titration analyses of the effects of 9-cis RA and D3 on HL60 cell differentiation were undertaken to determine the boundaries of the concentrations of each agent, alone and in combination, that give rise to optimal neutrophil and monocyte differentiation of HL60 cells .", "label": " ( cell line: HL60 cells, None) , ( cell line: HL60 cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL60 cells, None) , ( cell line: HL60 cell, None) " }

[]

{ "id": "1256", "sentence": "The observed cooperativities between either 9-cis RA or all-trans RA and D3 have important implications for the use of combinations of these agents in differentiation therapy .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1257", "sentence": "Isolation of differentially expressed sequence tags from steroid-responsive cells using mRNA differential display .", "label": " ( RNA: mRNA, None) , ( cell type: steroid-responsive cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: mRNA, None) , ( cell type: steroid-responsive cells, None) " }

[]

{ "id": "1258", "sentence": "Transcriptional control of steroid-regulated gene networks by nuclear receptor proteins results in the coordinate expression of a limited number of target genes .", "label": " ( DNA: target genes, None) , ( DNA: steroid-regulated gene networks, None) , ( protein: nuclear receptor proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: target genes, None) , ( DNA: steroid-regulated gene networks, None) , ( protein: nuclear receptor proteins, None) " }

[]

{ "id": "1259", "sentence": "Although much is known about the structure and function of steroid receptors, relatively few cell-specific steroid-regulated genes have been isolated and characterized.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1260", "sentence": "In this paper we describe results using mRNA differential display reverse transcriptase PCR ( DDPCR ) to identify and isolate short cDNA sequence tags from thymocyte and prostate cells under various hormone conditions .", "label": " ( cell type: prostate cells, None) , ( protein: reverse transcriptase, None) , ( cell type: thymocyte, None) , ( RNA: mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: prostate cells, None) , ( protein: reverse transcriptase, None) , ( cell type: thymocyte, None) , ( RNA: mRNA, None) " }

[]

{ "id": "1261", "sentence": "Using this technique we have isolated several differentially expressed sequence tags ( DESTs ) from the mouse thymocyte cell line WEHI 7.2 .", "label": " ( cell line: WEHI 7.2, None) , ( cell line: mouse thymocyte cell line, None) , ( DNA: differentially expressed sequence tags, None) , ( DNA: DESTs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: WEHI 7.2, None) , ( cell line: mouse thymocyte cell line, None) , ( DNA: differentially expressed sequence tags, None) , ( DNA: DESTs, None) " }

[]

{ "id": "1262", "sentence": "Two of these DESTs , GIG10 and GIG18 , are rapidly induced by dexamethasone within 2 h of treatment.", "label": " ( DNA: DESTs, None) , ( DNA: GIG18, None) , ( DNA: GIG10, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: DESTs, None) , ( DNA: GIG18, None) , ( DNA: GIG10, None) " }

[]

{ "id": "1263", "sentence": "GIG10 is a novel sequence and GIG18 is the mouse homologue of a human expressed sequence tag isolated from activated B lymphocytes .", "label": " ( DNA: GIG18, None) , ( cell type: activated B lymphocytes, None) , ( DNA: GIG10, None) , ( DNA: human expressed sequence tag, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: GIG18, None) , ( cell type: activated B lymphocytes, None) , ( DNA: GIG10, None) , ( DNA: human expressed sequence tag, None) " }

[]

{ "id": "1264", "sentence": "We also used DDPCR to isolate DESTs from androgen-modulated rat ventral prostate tissue , one of which we characterized and found to correspond to the 3' end of prostatic spermine binding protein mRNA , a known androgen-regulated gene .", "label": " ( RNA: prostatic spermine binding protein mRNA, None) , ( DNA: androgen-regulated gene, None) , ( RNA: 3#$%# end, None) , ( protein: prostatic spermine binding protein, None) , ( DNA: DESTs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: prostatic spermine binding protein mRNA, None) , ( DNA: androgen-regulated gene, None) , ( RNA: 3#$%# end, None) , ( protein: prostatic spermine binding protein, None) , ( DNA: DESTs, None) " }

[]

{ "id": "1265", "sentence": "Modifications of the original DDPCR protocol , which we found can potentially decrease the frequency of isolating false-positive DESTs , are described and the merits of DDPCR , relative to other differential cDNA cloning strategies , are discussed.", "label": " ( DNA: DESTs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: DESTs, None) " }

[]

{ "id": "1266", "sentence": "Activation of human thymocytes after infection by EBV .", "label": " ( cell type: human thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human thymocytes, None) " }

[]

{ "id": "1267", "sentence": "The discovery of EBV in certain T cell malignancies and the expression of the EBV receptor , CR2/CD21 , on a population of immature thymocytes , T lymphoblastoid cell lines , and childhood acute T lymphoblastic leukemia cells suggested that EBV -receptor interactions on T cells may be of importance.", "label": " ( cell type: immature thymocytes, None) , ( cell type: childhood acute T lymphoblastic leukemia cells, None) , ( protein: CR2/CD21, None) , ( protein: EBV receptor, None) , ( cell type: T cells, None) , ( cell line: T lymphoblastoid cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: immature thymocytes, None) , ( cell type: childhood acute T lymphoblastic leukemia cells, None) , ( protein: CR2/CD21, None) , ( protein: EBV receptor, None) , ( cell type: T cells, None) , ( cell line: T lymphoblastoid cell lines, None) " }

[]

{ "id": "1268", "sentence": "We have shown that, within the thymus , a population of large, immature cells expresses CD21 .", "label": " ( cell type: large, immature cells, None) , ( protein: CD21, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: large, immature cells, None) , ( protein: CD21, None) " }

[]

{ "id": "1269", "sentence": "EBV altered the activation responses of immature thymocytes in vitro.", "label": " ( cell type: immature thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: immature thymocytes, None) " }

[]

{ "id": "1270", "sentence": "Triggering through CD2 is mitogenic for mature, but not immature, T cells .", "label": " ( cell type: T cells, None) , ( protein: CD2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: CD2, None) " }

[]

{ "id": "1271", "sentence": "However, during infection by EBV , ligation of CD2 caused thymocytes to proliferate in the absence of exogenous cytokines .", "label": " ( cell type: thymocytes, None) , ( protein: CD2, None) , ( protein: exogenous cytokines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: thymocytes, None) , ( protein: CD2, None) , ( protein: exogenous cytokines, None) " }

[]

{ "id": "1272", "sentence": "This function was a result of the interaction of EBV with its receptor, CD21 , but was caused by infection rather than surface signaling, because neither specific mAb nor the P3HR-1 strain of virus mimicked the effect of B95-8.", "label": " ( protein: CD21, None) , ( protein: specific mAb, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD21, None) , ( protein: specific mAb, None) " }

[]

{ "id": "1273", "sentence": "Immature thymocytes were infected by EBV , as determined by the internalization of the viral genome and its transcriptional activity .", "label": " ( DNA: viral genome, None) , ( cell type: thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: viral genome, None) , ( cell type: thymocytes, None) " }

[]

{ "id": "1274", "sentence": "Consistent with the activity of B95-8 , EBNA-2 transcripts were identified within infected thymocyte populations .", "label": " ( protein: B95-8, None) , ( RNA: EBNA-2 transcripts, None) , ( cell type: thymocyte, None) , ( cell line: infected thymocyte populations, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: B95-8, None) , ( RNA: EBNA-2 transcripts, None) , ( cell type: thymocyte, None) , ( cell line: infected thymocyte populations, None) " }

[]

{ "id": "1275", "sentence": "In addition, components of the viral replicative pathway were expressed during infection of thymocytes .", "label": " ( cell type: thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: thymocytes, None) " }

[]

{ "id": "1276", "sentence": "These components included transcription of BZLF-1 , an early gene that characterizes EBV -infected B cells after disruption of latency.", "label": " ( cell type: EBV -infected B cells, None) , ( DNA: early gene, None) , ( DNA: BZLF-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: EBV -infected B cells, None) , ( DNA: early gene, None) , ( DNA: BZLF-1, None) " }

[]

{ "id": "1277", "sentence": "A second transcript was identified as encoding the recently characterized RAZ , which also is associated with replicative infection.", "label": " ( protein: RAZ, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RAZ, None) " }

[]

{ "id": "1278", "sentence": "The consequences of EBV infection of T cells at an early stage of differentiation may lead to failure of normal T cell repertoire development , autoimmunity , or malignancy .", "label": " ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) " }

[]

{ "id": "1279", "sentence": "Effects of intranasal glucocorticoids on endogenous glucocorticoid peripheral and central function .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1280", "sentence": "Glucocorticoids are among the most potent antiinflammatory agents that can be used in the treatment of rhinitis .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1281", "sentence": "Their mechanisms of action are multiple and complex and a number of reports describe significant systemic effects of locally administered glucocorticoids .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1282", "sentence": "In order to evaluate the short-term systemic effects of intranasally administered glucocorticoids , 14 normal healthy subjects were treated with two doses of either budesonide ( BUD ) or fluticasone propionate ( FP ) for 2 weeks.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1283", "sentence": "Before treatment, at regular intervals during the treatment, 1 week and finally 6 weeks after termination of treatment, the effects on glucocorticoid receptor (GR) and methallothionein (MTIIa) mRNA expression levels were examined in peripheral lymphocytes using a solution hybridization assay .", "label": " ( cell type: peripheral lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral lymphocytes, None) " }

[]

{ "id": "1284", "sentence": "Serum cortisol , osteocalcin and urinary cortisol levels were also determined.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1285", "sentence": "An insulin tolerance test ( ITT ) was performed at the end of the second week of treatment and at the end of the 6-week washout period with no statistically significant change in cortisol response.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1286", "sentence": "In peripheral lymphocytes , GR mRNA levels were significantly down-regulated.", "label": " ( cell type: peripheral lymphocytes, None) , ( RNA: GR mRNA, None) , ( protein: GR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral lymphocytes, None) , ( RNA: GR mRNA, None) , ( protein: GR, None) " }

[]

{ "id": "1287", "sentence": "MTIIa mRNA levels increased significantly.", "label": " ( protein: MTIIa, None) , ( RNA: MTIIa mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MTIIa, None) , ( RNA: MTIIa mRNA, None) " }

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{ "id": "1288", "sentence": "Serum osteocalcin decreased significantly during treatment with both BUD and FP .", "label": " ( protein: osteocalcin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: osteocalcin, None) " }

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{ "id": "1289", "sentence": "Serum cortisol decreased after 1 week of treatment whereas urinary cortisol was not affected until the second week of treatment.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1290", "sentence": "In conclusion, intranasal glucocorticoids at clinically recommended doses have not only significant systemic effects on adrenal function , but also have an effect on specific gene expression in peripheral lymphocytes .", "label": " ( cell type: peripheral lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral lymphocytes, None) " }

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{ "id": "1291", "sentence": "These effects are receptor-dependent, reversible, and according to serum and urinary cortisol levels and ITT , leave the hypothalamic-pituitary-adrenal function intact.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1292", "sentence": "Finally, these short-term systemic effects were not associated with any of the noticeable side-effects usually observed during long-term treatment with glucocorticoids .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1293", "sentence": "Biphasic control of nuclear factor-kappa B activation by the T cell receptor complex : role of tumor necrosis factor alpha .", "label": " ( protein: tumor necrosis factor alpha, None) , ( protein: nuclear factor-kappa B, None) , ( protein: T cell receptor complex, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tumor necrosis factor alpha, None) , ( protein: nuclear factor-kappa B, None) , ( protein: T cell receptor complex, None) " }

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{ "id": "1294", "sentence": "The regulation of nuclear factor (NF)-kappa B activation by the T cell receptor (TcR)/CD3 complex in primary human T cells has been studied at various times after activation.", "label": " ( protein: nuclear factor (NF)-kappa B, None) , ( protein: T cell receptor (TcR)/CD3 complex, None) , ( cell type: T cells, None) , ( protein: T cell receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor (NF)-kappa B, None) , ( protein: T cell receptor (TcR)/CD3 complex, None) , ( cell type: T cells, None) , ( protein: T cell receptor, None) " }

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{ "id": "1295", "sentence": "Only p50 NF-kappa B protein bound the kappa B element of interleukin-2 receptor ( IL-2R ) alpha chain promoter on resting T cells .", "label": " ( protein: p50 NF-kappa B protein, None) , ( cell type: T cells, None) , ( DNA: interleukin-2 receptor ( IL-2R ) alpha chain promoter, None) , ( protein: IL-2R, None) , ( protein: interleukin-2 receptor, None) , ( DNA: kappa B element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p50 NF-kappa B protein, None) , ( cell type: T cells, None) , ( DNA: interleukin-2 receptor ( IL-2R ) alpha chain promoter, None) , ( protein: IL-2R, None) , ( protein: interleukin-2 receptor, None) , ( DNA: kappa B element, None) " }

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{ "id": "1296", "sentence": "However, immediately after TcR/CD3 cross-linking (after approximately 1 h; immediate) binding of p50.p65 heterodimers was observed.", "label": " ( protein: TcR/CD3, None) , ( protein: p50.p65 heterodimers, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TcR/CD3, None) , ( protein: p50.p65 heterodimers, None) " }

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{ "id": "1297", "sentence": "p50.c-rel heterodimers were also detected bound to this sequence at early time points (7-16 h; early), and both remained active at later time points (40 h; late) after activation.", "label": " ( protein: p50.c-rel heterodimers, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p50.c-rel heterodimers, None) " }

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{ "id": "1298", "sentence": "This regulation takes place mainly at the level of nuclear translocation of p65 and c-rel , at immediate and early time points.", "label": " ( protein: c-rel, None) , ( protein: p65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c-rel, None) , ( protein: p65, None) " }

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{ "id": "1299", "sentence": "Activation also induced c-rel and p105/p50 mRNA synthesis , but not p65 mRNA whose expression was constitutive.", "label": " ( RNA: p65 mRNA, None) , ( protein: p65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: p65 mRNA, None) , ( protein: p65, None) " }