Datasets:

huy-nh-2000

/

instructUIE

like 0

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{ "id": "1300", "sentence": "Interestingly, all those early and late events, but not the immediate ones, were inhibited by a neutralizing anti- tumor necrosis factor alpha (TNF-alpha) monoclonal antibody .", "label": " ( protein: anti- tumor necrosis factor alpha (TNF-alpha) monoclonal antibody, None) , ( protein: tumor necrosis factor alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti- tumor necrosis factor alpha (TNF-alpha) monoclonal antibody, None) , ( protein: tumor necrosis factor alpha, None) " }

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{ "id": "1301", "sentence": "Similarly, cycloheximide prevented the p65 and c-rel translocation and consequent formation of active binding heterodimers, at early and late times.", "label": " ( protein: c-rel, None) , ( protein: p65, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c-rel, None) , ( protein: p65, None) " }

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{ "id": "1302", "sentence": "Cyclosporin A impaired not only early and late, but also immediate events; however, addition of TNF-alpha prevented all inhibition.", "label": " ( protein: TNF-alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF-alpha, None) " }

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{ "id": "1303", "sentence": "These results indicate that the regulation of NF-kappa B activation during T cell activation by TcR/CD3 signals is biphasic: TcR/CD3 triggers its immediate translocation, which is transient if no TNF-alpha is present.", "label": " ( protein: TcR/CD3, None) , ( protein: NF-kappa B, None) , ( protein: TcR/CD3, None) , ( protein: TNF-alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TcR/CD3, None) , ( protein: NF-kappa B, None) , ( protein: TcR/CD3, None) , ( protein: TNF-alpha, None) " }

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{ "id": "1304", "sentence": "TNF-alpha , therefore, emerges as the main factor responsible for a second phase of NF-kappa B regulation , controlling both translocation of p65 and c-rel , and new mRNA synthesis for c-rel and p105/p50 .", "label": " ( RNA: mRNA, None) , ( protein: NF-kappa B, None) , ( protein: p105/p50, None) , ( protein: p65, None) , ( protein: TNF-alpha, None) , ( protein: c-rel, None) , ( protein: c-rel, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: mRNA, None) , ( protein: NF-kappa B, None) , ( protein: p105/p50, None) , ( protein: p65, None) , ( protein: TNF-alpha, None) , ( protein: c-rel, None) , ( protein: c-rel, None) " }

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{ "id": "1305", "sentence": "The transcription factor Sp1 is required for induction of the murine GM-CSF promoter in T cells .", "label": " ( protein: transcription factor Sp1, None) , ( DNA: murine GM-CSF promoter, None) , ( cell type: T cells, None) , ( protein: Sp1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor Sp1, None) , ( DNA: murine GM-CSF promoter, None) , ( cell type: T cells, None) , ( protein: Sp1, None) " }

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{ "id": "1306", "sentence": "The cis-acting region , GM-kappa B/GC-box ( positions -95 and -73 ), within the murine GM-CSF gene promoter is required for maximal induction by stimulation with phorbol-12-myristate acetate ( PMA ) and calcium ionophore ( A23187 ) in T cells .", "label": " ( DNA: -73, None) , ( DNA: cis-acting region, None) , ( cell type: T cells, None) , ( DNA: murine GM-CSF gene promoter, None) , ( DNA: GM-kappa B/GC-box, None) , ( DNA: positions -95, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: -73, None) , ( DNA: cis-acting region, None) , ( cell type: T cells, None) , ( DNA: murine GM-CSF gene promoter, None) , ( DNA: GM-kappa B/GC-box, None) , ( DNA: positions -95, None) " }

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{ "id": "1307", "sentence": "GM-kappa B defines a binding site for NF-kappa B , and GC-box defines a binding site for three ( A1 , A2 , B ) constitutive proteins .", "label": " ( protein: A1, None) , ( protein: NF-kappa B, None) , ( protein: GM-kappa B, None) , ( protein: A2, None) , ( protein: constitutive proteins, None) , ( DNA: GC-box, None) , ( protein: B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: A1, None) , ( protein: NF-kappa B, None) , ( protein: GM-kappa B, None) , ( protein: A2, None) , ( protein: constitutive proteins, None) , ( DNA: GC-box, None) , ( protein: B, None) " }

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{ "id": "1308", "sentence": "We report here that three copies of the GC-box can functionally compensate for the GM-kappa B/ GC-box region , suggesting that the GC-motif can function independently of the GM-kappa B motif .", "label": " ( DNA: GC-motif, None) , ( DNA: GM-kappa B/ GC-box, None) , ( DNA: GM-kappa B/ GC-box region, None) , ( DNA: GC-box, None) , ( DNA: GM-kappa B motif, None) , ( DNA: GC-box, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: GC-motif, None) , ( DNA: GM-kappa B/ GC-box, None) , ( DNA: GM-kappa B/ GC-box region, None) , ( DNA: GC-box, None) , ( DNA: GM-kappa B motif, None) , ( DNA: GC-box, None) " }

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{ "id": "1309", "sentence": "The major GC-box binding activity A1 was purified and identified as the transcription factor Sp1 .", "label": " ( DNA: GC-box, None) , ( protein: transcription factor Sp1, None) , ( protein: Sp1, None) , ( protein: A1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: GC-box, None) , ( protein: transcription factor Sp1, None) , ( protein: Sp1, None) , ( protein: A1, None) " }

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{ "id": "1310", "sentence": "We show that depletion of Sp1 ( A1 ) from nuclear extracts specifically decreases in vitro transcription activity on GM-CSF templates .", "label": " ( protein: Sp1, None) , ( protein: GM-CSF, None) , ( protein: A1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Sp1, None) , ( protein: GM-CSF, None) , ( protein: A1, None) " }

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{ "id": "1311", "sentence": "Since the human GM-CSF promoter has a base difference within the GC-box , we speculate that this may explain why the human promoter is weak and that an upstream enhancer is required for the induction of the human GM-CSF gene .", "label": " ( DNA: GC-box, None) , ( DNA: upstream enhancer, None) , ( DNA: human GM-CSF gene, None) , ( DNA: human GM-CSF promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: GC-box, None) , ( DNA: upstream enhancer, None) , ( DNA: human GM-CSF gene, None) , ( DNA: human GM-CSF promoter, None) " }

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{ "id": "1312", "sentence": "A factor that regulates the class II major histocompatibility complex gene DPA is a member of a subfamily of zinc finger proteins that includes a Drosophila developmental control protein .", "label": " ( DNA: DPA, None) , ( protein: zinc finger proteins, None) , ( protein: Drosophila developmental control protein, None) , ( DNA: class II major histocompatibility complex gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: DPA, None) , ( protein: zinc finger proteins, None) , ( protein: Drosophila developmental control protein, None) , ( DNA: class II major histocompatibility complex gene, None) " }

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{ "id": "1313", "sentence": "A novel DNA sequence element termed the J element involved in the regulated expression of class II major histocompatibility complex genes was recently described.", "label": " ( DNA: J element, None) , ( DNA: DNA sequence element, None) , ( DNA: class II major histocompatibility complex genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: J element, None) , ( DNA: DNA sequence element, None) , ( DNA: class II major histocompatibility complex genes, None) " }

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{ "id": "1314", "sentence": "To study this element and its role in class II gene regulation further, a cDNA library was screened with oligonucleotide probes containing both the S element and the nearby J element of the human DPA gene .", "label": " ( DNA: class II gene, None) , ( DNA: cDNA library, None) , ( DNA: S element, None) , ( DNA: J element, None) , ( DNA: human DPA gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: class II gene, None) , ( DNA: cDNA library, None) , ( DNA: S element, None) , ( DNA: J element, None) , ( DNA: human DPA gene, None) " }

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{ "id": "1315", "sentence": "Several DNA clones were obtained by this procedure, one of which, clone 18 , is reported and characterized here.", "label": " ( DNA: DNA clones, None) , ( DNA: clone 18, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: DNA clones, None) , ( DNA: clone 18, None) " }

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{ "id": "1316", "sentence": "It encodes a protein predicted to contain 688 amino acid residues , including 11 zinc finger motifs of the C2H2 type in the C-terminal region , that are Kruppel-like in the conservation of the H/C link sequence connecting them.", "label": " ( protein: C-terminal region, None) , ( protein: C2H2 type, None) , ( protein: H/C link sequence, None) , ( protein: zinc finger motifs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: C-terminal region, None) , ( protein: C2H2 type, None) , ( protein: H/C link sequence, None) , ( protein: zinc finger motifs, None) " }

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{ "id": "1317", "sentence": "The 160 N-terminal amino acids in the nonfinger region of clone 18 are highly homologous with similar regions of several other human , mouse , and Drosophila sequences , defining a subfamily of Kruppel-like zinc finger proteins termed TAB ( tramtrack [ttk]-associated box ) here.", "label": " ( protein: clone 18, None) , ( protein: TAB, None) , ( protein: zinc finger proteins, None) , ( protein: 160 N-terminal amino acids, None) , ( protein: tramtrack [ttk]-associated box, None) , ( protein: nonfinger region, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: clone 18, None) , ( protein: TAB, None) , ( protein: zinc finger proteins, None) , ( protein: 160 N-terminal amino acids, None) , ( protein: tramtrack [ttk]-associated box, None) , ( protein: nonfinger region, None) " }

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{ "id": "1318", "sentence": "One of the Drosophila sequences , ttk , is a developmental control gene , while a second does not contain a zinc finger region but encodes a structure important in oocyte development .", "label": " ( DNA: Drosophila sequences, None) , ( DNA: developmental control gene, None) , ( DNA: ttk, None) , ( protein: zinc finger region, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Drosophila sequences, None) , ( DNA: developmental control gene, None) , ( DNA: ttk, None) , ( protein: zinc finger region, None) " }

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{ "id": "1319", "sentence": "An acidic activation domain is located between the N-terminal conserved region of clone 18 and its zinc fingers .", "label": " ( protein: zinc fingers, None) , ( protein: clone 18, None) , ( protein: N-terminal conserved region, None) , ( protein: acidic activation domain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: zinc fingers, None) , ( protein: clone 18, None) , ( protein: N-terminal conserved region, None) , ( protein: acidic activation domain, None) " }

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{ "id": "1320", "sentence": "This protein appears to require both the S and J elements , which are separated by 10 bp for optimal binding.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1321", "sentence": "Antisense cDNA to clone 18 inhibited the expression of a reporter construct containing the DPA promoter , indicating its functional importance in the expression of this class II gene .", "label": " ( DNA: class II gene, None) , ( DNA: DPA promoter, None) , ( DNA: DPA, None) , ( protein: clone 18, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: class II gene, None) , ( DNA: DPA promoter, None) , ( DNA: DPA, None) , ( protein: clone 18, None) " }

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{ "id": "1322", "sentence": "Separation of oxidant-initiated and redox-regulated steps in the NF-kappa B signal transduction pathway .", "label": " ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) " }

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{ "id": "1323", "sentence": "Studies presented here show that overall NF-kappa B signal transduction begins with a parallel series of stimuli-specific pathways through which cytokines ( tumor necrosis factor alpha ), oxidants ( hydrogen peroxide and mitomycin C ), and phorbol ester ( phorbol 12-myristate 13-acetate ) individually initiate signaling.", "label": " ( protein: tumor necrosis factor alpha, None) , ( protein: NF-kappa B, None) , ( protein: cytokines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tumor necrosis factor alpha, None) , ( protein: NF-kappa B, None) , ( protein: cytokines, None) " }

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{ "id": "1324", "sentence": "These initial pathways culminate in a common pathway through which all of the stimulating agents ultimately signal NF-kappa B activation .", "label": " ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) " }

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{ "id": "1325", "sentence": "We distinguish the stimuli-specific pathways by showing that the oxidative stimuli trigger NF-kappa B activation in only one of two human T-cell lines ( Wurzburg but not Jurkat ), whereas tumor necrosis factor alpha and phorbol 12-myristate 13-acetate readily stimulate in both lines.", "label": " ( cell line: Jurkat, None) , ( cell line: human T-cell lines, None) , ( cell line: Wurzburg, None) , ( protein: NF-kappa B, None) , ( protein: tumor necrosis factor alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Jurkat, None) , ( cell line: human T-cell lines, None) , ( cell line: Wurzburg, None) , ( protein: NF-kappa B, None) , ( protein: tumor necrosis factor alpha, None) " }

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{ "id": "1326", "sentence": "We propose the common pathway as the simplest way of accounting for the common requirements and properties of the signaling pathway.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1327", "sentence": "We include a redox-regulatory mechanism (s) in this common pathway to account for the previously demonstrated redox regulation of NF-kappa B activation in Jurkat cells (in which oxidants don't activate NF-kappa B ); we put tyrosine phosphorylation in the common pathway by showing that kinase activity (inhibitable by herbimycin A and tyrphostin 47 ) is required for NF-kappa B activation by all stimuli tested in both cell lines.", "label": " ( cell line: Jurkat cells, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Jurkat cells, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) " }

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{ "id": "1328", "sentence": "Since internal sites of oxidant production have been shown to play a key role in the cytokine -stimulated activation of NF-kappa B , and since tyrosine kinase and phosphatase activities are known to be altered by oxidants, these findings suggest that intracellular redox status controls NF-kappa B activation by regulating tyrosine phosphorylation event(s) within the common step of the NF-kappa B signal transduction pathway .", "label": " ( protein: NF-kappa B, None) , ( protein: cytokine, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: cytokine, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) " }

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{ "id": "1329", "sentence": "Deleted chromosome 20 from a patient with Alagille syndrome isolated in a cell hybrid through leucine transport selection : study of three candidate genes.", "label": " ( DNA: chromosome 20, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: chromosome 20, None) " }

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{ "id": "1330", "sentence": "Alagille syndrome ( AGS ) is a well-defined genetic entity assigned to the short arm of Chromosome (Chr) 20 by a series of observations of AGS patients associated with microdeletions in this region.", "label": " ( DNA: Chromosome (Chr) 20, None) , ( DNA: short arm, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Chromosome (Chr) 20, None) , ( DNA: short arm, None) " }

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{ "id": "1331", "sentence": "By fusing lymphoblastoid cells of an AGS patient that exhibited a microdeletion in the short arm of Chr 20 encompassing bands p11.23 to p12.3 with rodent thermosensitive mutant cells ( CHOtsH1-1 ) deficient in-leucyl-tRNA synthetase , we isolated a somatic cell hybrid segregating the deleted human Chr 20 .", "label": " ( DNA: Chr 20, None) , ( DNA: short arm of Chr 20, None) , ( DNA: Chr 20, None) , ( cell line: somatic cell hybrid, None) , ( cell line: rodent thermosensitive mutant cells, None) , ( protein: in-leucyl-tRNA synthetase, None) , ( DNA: p11.23 to p12.3, None) , ( cell line: CHOtsH1-1, None) , ( cell type: lymphoblastoid cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Chr 20, None) , ( DNA: short arm of Chr 20, None) , ( DNA: Chr 20, None) , ( cell line: somatic cell hybrid, None) , ( cell line: rodent thermosensitive mutant cells, None) , ( protein: in-leucyl-tRNA synthetase, None) , ( DNA: p11.23 to p12.3, None) , ( cell line: CHOtsH1-1, None) , ( cell type: lymphoblastoid cells, None) " }

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{ "id": "1332", "sentence": "This hybrid clone, designated NR2 , was characterized by several methods, including PCR , with eight pairs of oligonucleotides mapped to Chr 20 : D20S5 , D20S41 , D20S42 , D20S56 , D20S57 , D20S58 , adenosine deaminase ( ADA ), and Prion protein ( PRIP ); Restriction Fragment Length Polymorphism ( RFLP ) analyses with four genomic anonymous probes ( D20S5 , cD3H12 , D20S17 , D20S18 ); and fluorescent in situ hybridization ( FISH ) with total human DNA and D20Z1 , a sequence specific to the human Chr 20 centromere , as probes.", "label": " ( DNA: cD3H12, None) , ( DNA: D20S17, None) , ( DNA: D20S42, None) , ( DNA: D20S58, None) , ( protein: PRIP, None) , ( DNA: Chr 20, None) , ( DNA: genomic anonymous probes, None) , ( protein: Prion protein, None) , ( DNA: D20S41, None) , ( DNA: Chr 20, None) , ( DNA: human Chr 20 centromere, None) , ( DNA: D20S5, None) , ( DNA: RFLP, None) , ( DNA: D20S5, None) , ( DNA: total human DNA, None) , ( protein: adenosine deaminase, None) , ( DNA: D20S18, None) , ( DNA: D20Z1, None) , ( DNA: D20S57, None) , ( DNA: D20S56, None) , ( cell line: NR2, None) , ( protein: ADA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: cD3H12, None) , ( DNA: D20S17, None) , ( DNA: D20S42, None) , ( DNA: D20S58, None) , ( protein: PRIP, None) , ( DNA: Chr 20, None) , ( DNA: genomic anonymous probes, None) , ( protein: Prion protein, None) , ( DNA: D20S41, None) , ( DNA: Chr 20, None) , ( DNA: human Chr 20 centromere, None) , ( DNA: D20S5, None) , ( DNA: RFLP, None) , ( DNA: D20S5, None) , ( DNA: total human DNA, None) , ( protein: adenosine deaminase, None) , ( DNA: D20S18, None) , ( DNA: D20Z1, None) , ( DNA: D20S57, None) , ( DNA: D20S56, None) , ( cell line: NR2, None) , ( protein: ADA, None) " }

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{ "id": "1333", "sentence": "The NR2 hybrid allowed us to exclude three candidate genes for AGS : hepatic nuclear factor 3 beta ( HNF3 beta ), paired box 1 ( PAX1 ), and cystatin C ( CST3 ) as shown by their localization outside of the deletion.", "label": " ( DNA: candidate genes, None) , ( DNA: CST3, None) , ( cell line: NR2 hybrid, None) , ( DNA: cystatin C, None) , ( DNA: PAX1, None) , ( DNA: paired box 1, None) , ( DNA: HNF3 beta, None) , ( DNA: hepatic nuclear factor 3 beta, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: candidate genes, None) , ( DNA: CST3, None) , ( cell line: NR2 hybrid, None) , ( DNA: cystatin C, None) , ( DNA: PAX1, None) , ( DNA: paired box 1, None) , ( DNA: HNF3 beta, None) , ( DNA: hepatic nuclear factor 3 beta, None) " }

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{ "id": "1334", "sentence": "The NR2 hybrid is a powerful tool for the mapping of new probes of this region, as well as for obtaining new informative probes specific for the deletion by subtractive cloning of the region.", "label": " ( cell line: NR2 hybrid, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: NR2 hybrid, None) " }

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{ "id": "1335", "sentence": "Such markers will be useful for linkage analysis and screening of cDNA libraries .", "label": " ( DNA: cDNA libraries, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: cDNA libraries, None) " }

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{ "id": "1336", "sentence": "Positive and negative regulation of the composite octamer motif of the interleukin 2 enhancer by AP-1 , Oct-2 , and retinoic acid receptor .", "label": " ( protein: AP-1, None) , ( DNA: interleukin 2 enhancer, None) , ( protein: retinoic acid receptor, None) , ( DNA: composite octamer motif, None) , ( protein: Oct-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( DNA: interleukin 2 enhancer, None) , ( protein: retinoic acid receptor, None) , ( DNA: composite octamer motif, None) , ( protein: Oct-2, None) " }

[]

{ "id": "1337", "sentence": "The differentiating agent retinoic acid ( RA ) has been previously reported to interfere with 12-O-tetradecanoyl-phorbol-13-acetate ( TPA )/ Ca(2+) -induced signals for the regulation of the -96 to -66-bp octamer motif found in the enhancer for the interleukin (IL)-2 gene , which encodes a major T lymphocyte growth factor .", "label": " ( protein: T lymphocyte growth factor, None) , ( DNA: interleukin (IL)-2 gene, None) , ( DNA: -96 to -66-bp octamer motif, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: T lymphocyte growth factor, None) , ( DNA: interleukin (IL)-2 gene, None) , ( DNA: -96 to -66-bp octamer motif, None) " }

[]

{ "id": "1338", "sentence": "The IL-2 octamer motif is a composite cis-element which binds Oct-1 and Oct-2 as well as a TPA / Ca(2+) -inducible nuclear factor , previously termed octamer-associated protein ( OAP40 ).", "label": " ( protein: Oct-1, None) , ( protein: IL-2, None) , ( protein: OAP40, None) , ( DNA: IL-2 octamer motif, None) , ( protein: octamer-associated protein, None) , ( DNA: cis-element, None) , ( protein: Oct-2, None) , ( protein: TPA / Ca(2+) -inducible nuclear factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-1, None) , ( protein: IL-2, None) , ( protein: OAP40, None) , ( DNA: IL-2 octamer motif, None) , ( protein: octamer-associated protein, None) , ( DNA: cis-element, None) , ( protein: Oct-2, None) , ( protein: TPA / Ca(2+) -inducible nuclear factor, None) " }

[]

{ "id": "1339", "sentence": "We show here that Oct-2 , despite the presence of an active transcriptional activation domain, requires TPA/Ca(2+)-induced signals to strongly transactivate the IL-2 octamer motif in Jurkat T cells.", "label": " ( protein: IL-2, None) , ( protein: Oct-2, None) , ( DNA: IL-2 octamer motif, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( protein: Oct-2, None) , ( DNA: IL-2 octamer motif, None) " }

[]

{ "id": "1340", "sentence": "This Oct-2 -dependent transactivation is inhibited by RA .", "label": " ( protein: Oct-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-2, None) " }

[]

{ "id": "1341", "sentence": "The presence of an intact COOH-terminal domain of Oct-2 contributes to both TPA / Ca(2+) -induced transactivation and the RA -mediated repression.", "label": " ( protein: intact COOH-terminal domain, None) , ( protein: Oct-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: intact COOH-terminal domain, None) , ( protein: Oct-2, None) " }

[]

{ "id": "1342", "sentence": "We also show that both Fos and Jun components of the AP-1 factors participate in the OAP40 complex .", "label": " ( protein: OAP40 complex, None) , ( protein: Fos, None) , ( protein: Jun, None) , ( protein: AP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: OAP40 complex, None) , ( protein: Fos, None) , ( protein: Jun, None) , ( protein: AP-1, None) " }

[]

{ "id": "1343", "sentence": "Furthermore, transfected c-jun , jun-B , jun-D , c-fos , or Fos-B expression vectors partially substitute for TPA and Ca2+ and cooperate with Oct-2 for the transactivation of the combined OAP/octamer cis-element .", "label": " ( protein: Oct-2, None) , ( DNA: OAP/octamer cis-element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-2, None) , ( DNA: OAP/octamer cis-element, None) " }

[]

{ "id": "1344", "sentence": "Mutations of the genuine octamer-binding site abrogate both the binding of Oct-1 and Oct-2 and the TPA / Ca(2+) -induced transactivation of the OAP /octamer motif .", "label": " ( protein: OAP, None) , ( DNA: OAP /octamer motif, None) , ( DNA: genuine octamer-binding site, None) , ( protein: Oct-2, None) , ( protein: Oct-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: OAP, None) , ( DNA: OAP /octamer motif, None) , ( DNA: genuine octamer-binding site, None) , ( protein: Oct-2, None) , ( protein: Oct-1, None) " }

[]

{ "id": "1345", "sentence": "OAP confers to Oct-2 responsivity to both TPA /Ca2+ and RA , since specific mutations of the AP-1 / OAP -binding site significantly reduce the transactivation by Oct-2 in response to TPA and Ca2+ and abolish the inhibition by RA .", "label": " ( protein: AP-1, None) , ( DNA: AP-1 / OAP -binding site, None) , ( protein: Oct-2, None) , ( protein: Oct-2, None) , ( protein: OAP, None) , ( protein: OAP, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( DNA: AP-1 / OAP -binding site, None) , ( protein: Oct-2, None) , ( protein: Oct-2, None) , ( protein: OAP, None) , ( protein: OAP, None) " }

[]

{ "id": "1346", "sentence": "Furthermore, retinoic acid receptor ( RAR ) alpha is able to inhibit in vitro the formation of the complex between the nuclear AP-1 /OAP and its specific binding site, resulting in the interference with Oct-2 -dependent cis-regulatory function of this AP-1 element.", "label": " ( protein: Oct-2, None) , ( protein: AP-1, None) , ( protein: AP-1, None) , ( protein: RAR, None) , ( protein: /OAP, None) , ( protein: retinoic acid receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-2, None) , ( protein: AP-1, None) , ( protein: AP-1, None) , ( protein: RAR, None) , ( protein: /OAP, None) , ( protein: retinoic acid receptor, None) " }

[]

{ "id": "1347", "sentence": "Therefore, we propose that the TPA / calcium -activated AP-1 /OAP element is the main target of positive or negative regulatory signals influencing the IL-2 octamer motif , through synergism with Oct-2 and antagonism by RAR .", "label": " ( protein: Oct-2, None) , ( DNA: IL-2 octamer motif, None) , ( protein: RAR, None) , ( protein: IL-2, None) , ( protein: AP-1, None) , ( protein: /OAP, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct-2, None) , ( DNA: IL-2 octamer motif, None) , ( protein: RAR, None) , ( protein: IL-2, None) , ( protein: AP-1, None) , ( protein: /OAP, None) " }

[]

{ "id": "1348", "sentence": "Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency .", "label": " ( DNA: exon 7, None) , ( DNA: common gamma chain gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: exon 7, None) , ( DNA: common gamma chain gene, None) " }

[]

{ "id": "1349", "sentence": "Clinical and immunologic features of a recently recognized X-linked combined immunodeficiency disease ( XCID ) suggested that XCID and X-linked severe combined immunodeficiency ( XSCID ) might arise from different genetic defects .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1350", "sentence": "The recent discovery of mutations in the common gamma chain (gamma c) gene , a constituent of several cytokine receptors , in XSCID provided an opportunity to test directly whether a previously unrecognized mutation in this same gene was responsible for XCID .", "label": " ( DNA: common gamma chain (gamma c) gene, None) , ( protein: cytokine receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: common gamma chain (gamma c) gene, None) , ( protein: cytokine receptors, None) " }

[]

{ "id": "1351", "sentence": "The status of X chromosome inactivation in blood leukocytes from obligate carriers of XCID was determined from the polymorphic, short tandem repeats ( CAG ), in the androgen receptor gene , which also contains a methylation-sensitive HpaII site .", "label": " ( DNA: methylation-sensitive HpaII site, None) , ( DNA: androgen receptor gene, None) , ( DNA: X chromosome, None) , ( DNA: short tandem repeats, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: methylation-sensitive HpaII site, None) , ( DNA: androgen receptor gene, None) , ( DNA: X chromosome, None) , ( DNA: short tandem repeats, None) " }

[]

{ "id": "1352", "sentence": "As in XSCID, X-chromosome inactivation in obligate carriers of XCID was nonrandom in T and B lymphocytes .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1353", "sentence": "In addition, X chromosome inactivation in PMNs was variable.", "label": " ( DNA: X chromosome, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: X chromosome, None) " }

[]

{ "id": "1354", "sentence": "Findings from this analysis prompted sequencing of the gamma c gene in this pedigree.", "label": " ( DNA: gamma c gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: gamma c gene, None) " }

[]

{ "id": "1355", "sentence": "A missense mutation in the region coding for the cytoplasmic portion of the gamma c gene was found in three affected males but not in a normal brother.", "label": " ( DNA: gamma c gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: gamma c gene, None) " }

[]

{ "id": "1356", "sentence": "Therefore, this point mutation in the gamma c gene leads to a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID .", "label": " ( DNA: gamma c gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: gamma c gene, None) " }

[]

{ "id": "1357", "sentence": "Posttranscriptional regulation of macrophage tissue factor expression by antioxidants .", "label": " ( protein: tissue factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tissue factor, None) " }

[]

{ "id": "1358", "sentence": "Tissue factor ( TF ) expression by cells of monocyte/macrophage lineage represents an important mechanism underlying the initiation of fibrin deposition at sites of extravascular inflammation .", "label": " ( protein: Tissue factor, None) , ( protein: TF, None) , ( cell type: monocyte/macrophage lineage, None) , ( protein: fibrin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tissue factor, None) , ( protein: TF, None) , ( cell type: monocyte/macrophage lineage, None) , ( protein: fibrin, None) " }

[]

{ "id": "1359", "sentence": "Recent evidence suggests a role for oxidant stress in the signalling pathway of various cell types by virtue of its ability to induce DNA binding of various transcription factors , including nuclear factor kappa B and AP-1 .", "label": " ( protein: nuclear factor kappa B, None) , ( protein: AP-1, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor kappa B, None) , ( protein: AP-1, None) , ( protein: transcription factors, None) " }

[]

{ "id": "1360", "sentence": "The effect of antioxidant treatment on lipopolysaccharide ( LPS )-induced TF expression was examined in murine peritoneal macrophages and human monocytes .", "label": " ( cell type: murine peritoneal macrophages, None) , ( cell type: human monocytes, None) , ( protein: TF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: murine peritoneal macrophages, None) , ( cell type: human monocytes, None) , ( protein: TF, None) " }

[]

{ "id": "1361", "sentence": "Both pyrrolidine dithiocarbamate , an oxidant scavenger , and N-acetyl-cysteine , a precursor of the endogenous antioxidant glutathione , inhibited stimulation of macrophage procoagulant activity by LPS .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "1362", "sentence": "Northern blot analysis showed that neither of these agents reduced LPS -stimulated TF mRNA accumulation , thereby suggesting a posttranscriptional mechanism for the effect.", "label": " ( protein: TF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TF, None) " }

[]

{ "id": "1363", "sentence": "Immunofluorescence studies of human monocytes using polyclonal anti- TF antibody showed that N-acetyl-cysteine treatment prevented the characteristic plasmalemmal localization of TF antigen that occurs in response to LPS .", "label": " ( protein: anti- TF antibody, None) , ( protein: TF antigen, None) , ( protein: TF, None) , ( protein: TF, None) , ( cell type: human monocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti- TF antibody, None) , ( protein: TF antigen, None) , ( protein: TF, None) , ( protein: TF, None) , ( cell type: human monocytes, None) " }

[]

{ "id": "1364", "sentence": "Western blot analysis showed that N-acetyl-cysteine reduced the accumulation of the 47-kD mature glycoprotein in LPS -treated cells , a finding consistent with the results of the immunofluorescence studies .", "label": " ( cell line: LPS -treated cells, None) , ( protein: 47-kD mature glycoprotein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: LPS -treated cells, None) , ( protein: 47-kD mature glycoprotein, None) " }

[]

{ "id": "1365", "sentence": "Furthermore, these conditions did not result in an accumulation of the less mature forms of TF .", "label": " ( protein: TF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TF, None) " }

[]

{ "id": "1366", "sentence": "When considered together, these data suggest that antioxidants exert their effects by impairing translation and/or by causing degradation of newly translated protein .", "label": " ( protein: translated protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: translated protein, None) " }

[]

{ "id": "1367", "sentence": "The effect of antioxidants on tumor necrosis factor appeared to be species specific, with no effect on LPS -induced tumor necrosis factor in murine cells, but with inhibition in human monocytes .", "label": " ( protein: tumor necrosis factor, None) , ( cell type: human monocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tumor necrosis factor, None) , ( cell type: human monocytes, None) " }

[]

{ "id": "1368", "sentence": "The posttranscriptional effect of antioxidants on TF expression data suggests a novel mechanism whereby these agents might modulate monocyte /macrophage activation .", "label": " ( cell type: monocyte, None) , ( protein: TF, None) , ( cell type: /macrophage, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocyte, None) , ( protein: TF, None) , ( cell type: /macrophage, None) " }

[]

{ "id": "1369", "sentence": "Characterization of the CD48 gene demonstrates a positive element that is specific to Epstein-Barr virus -immortalized B-cell lines and contains an essential NF-kappa B site .", "label": " ( cell type: Epstein-Barr virus -immortalized B-cell lines, None) , ( protein: NF-kappa B, None) , ( DNA: NF-kappa B site, None) , ( DNA: CD48 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: Epstein-Barr virus -immortalized B-cell lines, None) , ( protein: NF-kappa B, None) , ( DNA: NF-kappa B site, None) , ( DNA: CD48 gene, None) " }

[]

{ "id": "1370", "sentence": "Epstein-Barr virus ( EBV ) infection of mature, resting B cells drives them to become lymphoblasts expressing high levels of cell surface molecules, such as CD48 , characteristically expressed on normal activated B cells .", "label": " ( protein: CD48, None) , ( cell type: resting B cells, None) , ( cell type: normal activated B cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD48, None) , ( cell type: resting B cells, None) , ( cell type: normal activated B cells, None) " }

[]

{ "id": "1371", "sentence": "Here, we report on the identification of an enhancer element in the CD48 gene which reproducibly confers strong transcriptional activity only in EBV -positive B-lymphoblastoid cell lines .", "label": " ( DNA: enhancer element, None) , ( DNA: CD48 gene, None) , ( protein: CD48, None) , ( cell line: EBV -positive B-lymphoblastoid cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: enhancer element, None) , ( DNA: CD48 gene, None) , ( protein: CD48, None) , ( cell line: EBV -positive B-lymphoblastoid cell lines, None) " }

[]

{ "id": "1372", "sentence": "The element is not activated upon infection of established EBV -negative B-cell lines , indicating that EBV fails to drive these cells to a fully lymphoblastoid phenotype .", "label": " ( cell type: lymphoblastoid phenotype, None) , ( cell line: EBV -negative B-cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphoblastoid phenotype, None) , ( cell line: EBV -negative B-cell lines, None) " }

[]

{ "id": "1373", "sentence": "An NF-kappa B binding site is an essential component of the element but alone is not sufficient to account for the activity or the specificity of the element.", "label": " ( protein: NF-kappa B, None) , ( DNA: NF-kappa B binding site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( DNA: NF-kappa B binding site, None) " }

[]

{ "id": "1374", "sentence": "We have detected a specific nuclear protein complex that binds to the element and show that NF-kappa B1 ( p50 ) is a part of this complex.", "label": " ( protein: nuclear protein complex, None) , ( protein: NF-kappa B1, None) , ( protein: p50, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear protein complex, None) , ( protein: NF-kappa B1, None) , ( protein: p50, None) " }

[]

{ "id": "1375", "sentence": "The EBV -encoded latent membrane protein 1 is capable of transactivating the isolated CD48 NF-kappa B site but not the intact element , suggesting that the latent membrane protein 1 -driven activation of NF-kappa B/Rel must interact with other regulatory pathways to control expression of cellular genes as EBV drives resting B cells into the cell cycle .", "label": " ( protein: latent membrane protein 1, None) , ( protein: CD48, None) , ( protein: NF-kappa B, None) , ( cell type: resting B cells, None) , ( DNA: intact element, None) , ( DNA: NF-kappa B site, None) , ( protein: NF-kappa B/Rel, None) , ( protein: EBV -encoded latent membrane protein 1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: latent membrane protein 1, None) , ( protein: CD48, None) , ( protein: NF-kappa B, None) , ( cell type: resting B cells, None) , ( DNA: intact element, None) , ( DNA: NF-kappa B site, None) , ( protein: NF-kappa B/Rel, None) , ( protein: EBV -encoded latent membrane protein 1, None) " }

[]

{ "id": "1376", "sentence": "Thapsigargin induces IL-2 receptor alpha-chain in human peripheral and Jurkat T cells via a protein kinase C -independent mechanism .", "label": " ( cell type: human peripheral, None) , ( cell line: Jurkat T cells, None) , ( protein: protein kinase C, None) , ( protein: IL-2 receptor alpha-chain, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human peripheral, None) , ( cell line: Jurkat T cells, None) , ( protein: protein kinase C, None) , ( protein: IL-2 receptor alpha-chain, None) " }

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{ "id": "1377", "sentence": "Thapsigargin ( TG ), an inhibitor of Ca(2+)-ATPase , depletes intracellular Ca2+ stores and induces a sustained Ca2+ influx without altering phosphatidyl inositol levels .", "label": " ( protein: Ca(2+)-ATPase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Ca(2+)-ATPase, None) " }

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{ "id": "1378", "sentence": "TG plus phorbol myristate acetate ( PMA ) but not TG alone induced IL-2 in Jurkat T cells , suggesting that TG had no effect on protein kinase C ( PKC ).", "label": " ( protein: PKC, None) , ( protein: IL-2, None) , ( protein: protein kinase C, None) , ( cell line: Jurkat T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC, None) , ( protein: IL-2, None) , ( protein: protein kinase C, None) , ( cell line: Jurkat T cells, None) " }

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{ "id": "1379", "sentence": "However, TG induced increases in IL-2R alpha protein as well as IL-2R alpha mRNA in Jurkat T cells in a dose-dependent manner.", "label": " ( RNA: IL-2R alpha mRNA, None) , ( cell line: Jurkat T cells, None) , ( protein: IL-2R alpha protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: IL-2R alpha mRNA, None) , ( cell line: Jurkat T cells, None) , ( protein: IL-2R alpha protein, None) " }

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{ "id": "1380", "sentence": "A similar increase in IL-2R alpha by TG was also observed in human peripheral T cells .", "label": " ( protein: IL-2R alpha, None) , ( cell type: human peripheral T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2R alpha, None) , ( cell type: human peripheral T cells, None) " }

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{ "id": "1381", "sentence": "Further, like PMA , TG markedly induced NF kappa B in Jurkat T cells .", "label": " ( protein: NF kappa B, None) , ( cell line: Jurkat T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF kappa B, None) , ( cell line: Jurkat T cells, None) " }

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{ "id": "1382", "sentence": "However, TG and PMA exhibited a synergistic action on IL-2R alpha expression, suggesting that TG and PMA induce IL-2R alpha through distinct pathways.", "label": " ( protein: IL-2R alpha, None) , ( protein: IL-2R alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2R alpha, None) , ( protein: IL-2R alpha, None) " }

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{ "id": "1383", "sentence": "PMA -but not TG -induced IL-2R alpha is inhibited by the PKC inhibitor H7 , whereas TG -but not PMA -induced IL-2R alpha was inhibited by cholera toxin , forskolin and 1,9-dideoxy forskolin .", "label": " ( protein: PKC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC, None) " }

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{ "id": "1384", "sentence": "In toto, these results suggest that TG induces IL-2R alpha in human T cells through a PKC -independent pathway .", "label": " ( protein: PKC, None) , ( protein: IL-2R alpha, None) , ( cell type: human T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC, None) , ( protein: IL-2R alpha, None) , ( cell type: human T cells, None) " }

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{ "id": "1385", "sentence": "Physiological concentration of estradiol inhibits polymorphonuclear leukocyte chemotaxis via a receptor mediated system.", "label": " ( cell type: polymorphonuclear leukocyte, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: polymorphonuclear leukocyte, None) " }

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{ "id": "1386", "sentence": "Estrogen exhibits a variety of actions, including immuno-modulatory effects , in vivo and in vitro.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1387", "sentence": "The mechanism by which estrogen exerts its anti-inflammatory effect is not yet understood.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "1388", "sentence": "We investigated the possible mechanisms of estradiol acting via the polymorphonuclear leukocytes ( PMNs ), which are important in the immune response .", "label": " ( cell type: PMNs, None) , ( cell type: polymorphonuclear leukocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PMNs, None) , ( cell type: polymorphonuclear leukocytes, None) " }

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{ "id": "1389", "sentence": "The agent, 17 beta- estradiol , but not 17 alpha- estradiol , significantly reduced PMNs chemotaxis to FMLP in a dose-dependent manner (control vs estrogen 10(-10)-(-6) M, P < 0.05).", "label": " ( cell type: PMNs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PMNs, None) " }

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{ "id": "1390", "sentence": "Physiological concentrations of estradiol significantly reduced the chemotaxis of PMNs (10(-10) mol).", "label": " ( cell type: PMNs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PMNs, None) " }

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{ "id": "1391", "sentence": "Pre-incubation with clomiphene or tamoxifen which are estrogen receptor antagonists, eliminated the inhibitory effect of 17 beta- estradiol on the chemotaxis of PMNs , restoring it to the control level.", "label": " ( cell type: PMNs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PMNs, None) " }

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{ "id": "1392", "sentence": "These observations suggest that 17 beta- estradiol suppressed the chemotaxis of PMNs by a receptor-dependent mechanism .", "label": " ( cell type: PMNs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PMNs, None) " }

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{ "id": "1393", "sentence": "In addition, the level of estradiol in human plasma , which PMNs were drawn, showed a close, inverse correlation with the PMNs chemotaxis to FMLP (r = -0.821 p < 0.001).", "label": " ( cell type: human plasma, None) , ( cell type: PMNs, None) , ( cell type: PMNs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human plasma, None) , ( cell type: PMNs, None) , ( cell type: PMNs, None) " }

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{ "id": "1394", "sentence": "Estrogen may modify the activity of neutrophils during the normal menstrual cycle, not only during pregnancy, and influence inflammation.", "label": " ( cell type: neutrophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: neutrophils, None) " }

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{ "id": "1395", "sentence": "Identification of the TCL1 gene involved in T-cell malignancies .", "label": " ( cell type: T-cell, None) , ( DNA: TCL1 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T-cell, None) , ( DNA: TCL1 gene, None) " }

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{ "id": "1396", "sentence": "The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T-cell receptor loci in human T-cell leukemias and lymphomas .", "label": " ( DNA: T-cell receptor loci, None) , ( DNA: chromosome 14q32.1, None) , ( DNA: TCL1 locus, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: T-cell receptor loci, None) , ( DNA: chromosome 14q32.1, None) , ( DNA: TCL1 locus, None) " }

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{ "id": "1397", "sentence": "The chromosome 14 region translocated or rearranged involves approximately 350 kb of DNA at chromosome band 14q32.1 .", "label": " ( DNA: chromosome 14, None) , ( DNA: chromosome band 14q32.1, None) , ( DNA: chromosome 14 region, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: chromosome 14, None) , ( DNA: chromosome band 14q32.1, None) , ( DNA: chromosome 14 region, None) " }

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{ "id": "1398", "sentence": "Within this region we have identified a gene coding for a 1.3-kb transcript , expressed only in restricted subsets of cells within the lymphoid lineage and expressed at high levels in leukemic cells carrying a t(14;14)(q11;q32) chromosome translocation or a inv(14)(q11;q32) chromosome inversion .", "label": " ( cell type: leukemic cells, None) , ( cell type: lymphoid lineage, None) , ( RNA: 1.3-kb transcript, None) , ( DNA: t(14;14)(q11;q32) chromosome translocation, None) , ( DNA: inv(14)(q11;q32) chromosome inversion, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: leukemic cells, None) , ( cell type: lymphoid lineage, None) , ( RNA: 1.3-kb transcript, None) , ( DNA: t(14;14)(q11;q32) chromosome translocation, None) , ( DNA: inv(14)(q11;q32) chromosome inversion, None) " }

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{ "id": "1399", "sentence": "The cognate cDNA sequence reveals an open reading frame of 342 nt encoding a protein of 14 kDa .", "label": " ( DNA: open reading frame, None) , ( DNA: cognate cDNA sequence, None) , ( protein: protein of 14 kDa, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: open reading frame, None) , ( DNA: cognate cDNA sequence, None) , ( protein: protein of 14 kDa, None) " }