Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "3500", "sentence": "The mean concentrations necessary to cause 50% inhibition of lymphocyte proliferation ( IC50s ) for the steroid-sensitive group ranged from 2 x 10(-10) mol/L for budesonide to 7 x 10(-8) mol/L for hydrocortisone , whereas the mean IC50s for the steroid-resistant group ranged from approximately 2 x 10(-8) mol/L for budesonide to greater than 10(-6) mol/L for hydrocortisone .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3501", "sentence": "In addition, a significant correlation was noted between the degree of inhibition of lymphocyte proliferation ( IC50 ) and the binding affinity of dexamethasone to the GCR .", "label": " ( protein: GCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCR, None) " }

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{ "id": "3502", "sentence": "Patients with steroid-resistant asthma have been shown to have a reduced GCR binding affinity .", "label": " ( protein: GCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCR, None) " }

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{ "id": "3503", "sentence": "The GCR binding affinity for budesonide was significantly higher in both groups (i.e., lower dissociation constant ) than that obtained for dexamethasone .", "label": " ( protein: GCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCR, None) " }

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{ "id": "3504", "sentence": "CONCLUSION: These data suggest that glucocorticoids such as budesonide , by virtue of their high GCR binding affinities and greater ability to suppress lymphocyte proliferation , may therefore be beneficial in the management of difficult-to-control asthma .", "label": " ( protein: GCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GCR, None) " }

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{ "id": "3505", "sentence": "Characterization of the murine cyclin-dependent kinase inhibitor gene p27Kip1 .", "label": " ( DNA: murine cyclin-dependent kinase inhibitor gene, None) , ( DNA: p27Kip1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: murine cyclin-dependent kinase inhibitor gene, None) , ( DNA: p27Kip1, None) " }

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{ "id": "3506", "sentence": "The cyclin-dependent kinase inhibitor p27Kip1 plays an important role in regulating cell-cycle progression .", "label": " ( DNA: p27Kip1, None) , ( DNA: cyclin-dependent kinase inhibitor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: p27Kip1, None) , ( DNA: cyclin-dependent kinase inhibitor, None) " }

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{ "id": "3507", "sentence": "p27Kip1 directly inhibits the catalytic activity of cyclin/cdks ( cyclin-dependent kinase ) complexes and/or interferes physically with cyclin/cdks activation by CAK .", "label": " ( protein: CAK, None) , ( protein: cyclin/cdks, None) , ( protein: cyclin/cdks ( cyclin-dependent kinase ) complexes, None) , ( DNA: p27Kip1, None) , ( protein: cyclin-dependent kinase, None) , ( protein: cyclin/cdks, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CAK, None) , ( protein: cyclin/cdks, None) , ( protein: cyclin/cdks ( cyclin-dependent kinase ) complexes, None) , ( DNA: p27Kip1, None) , ( protein: cyclin-dependent kinase, None) , ( protein: cyclin/cdks, None) " }

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{ "id": "3508", "sentence": "Interestingly, the expression level of p27Kip1 mRNA was maximal in resting Go T-cells and rapidly declined following anti-CD3 activation .", "label": " ( DNA: p27Kip1, None) , ( protein: anti-CD3, None) , ( cell type: resting Go T-cells, None) , ( RNA: p27Kip1 mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: p27Kip1, None) , ( protein: anti-CD3, None) , ( cell type: resting Go T-cells, None) , ( RNA: p27Kip1 mRNA, None) " }

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{ "id": "3509", "sentence": "We report here the cloning of p27Kip1 gene from murine genomic DNA and the functional analysis of the promoter of the p27Kip1 gene.", "label": " ( DNA: p27Kip1 gene, None) , ( DNA: p27Kip1, None) , ( DNA: murine genomic DNA, None) , ( DNA: p27Kip1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: p27Kip1 gene, None) , ( DNA: p27Kip1, None) , ( DNA: murine genomic DNA, None) , ( DNA: p27Kip1, None) " }

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{ "id": "3510", "sentence": "The gene consists of at least three exons and spans more than 5.6 kb of DNA .", "label": " ( DNA: 5.6 kb of DNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: 5.6 kb of DNA, None) " }

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{ "id": "3511", "sentence": "Primer extension and nuclease S1 protection analysis revealed two major transcription initiation sites .", "label": " ( DNA: transcription initiation sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: transcription initiation sites, None) " }

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{ "id": "3512", "sentence": "The promoter region lacked a TATA box but contained potential binding sites for the transcriptional factors including two Sp1 , CRE , Myb and NFkB located at positions -153 , -178 , -286 , -875 , and -1011 , respectively.", "label": " ( protein: NFkB, None) , ( DNA: TATA box, None) , ( protein: transcriptional factors, None) , ( protein: CRE, None) , ( protein: Myb, None) , ( protein: Sp1, None) , ( DNA: promoter region, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NFkB, None) , ( DNA: TATA box, None) , ( protein: transcriptional factors, None) , ( protein: CRE, None) , ( protein: Myb, None) , ( protein: Sp1, None) , ( DNA: promoter region, None) " }

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{ "id": "3513", "sentence": "To analyze the regulatory mechanisms controlling p27Kip1 gene expression, we characterized the 5'-flanking region from nt -1609 to +178 .", "label": " ( DNA: p27Kip1, None) , ( DNA: 5#$%#-flanking region, None) , ( DNA: nt -1609 to +178, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: p27Kip1, None) , ( DNA: 5#$%#-flanking region, None) , ( DNA: nt -1609 to +178, None) " }

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{ "id": "3514", "sentence": "The -326 to -615 region contained positive regulatory elements .", "label": " ( DNA: positive regulatory elements, None) , ( DNA: -326 to -615 region, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: positive regulatory elements, None) , ( DNA: -326 to -615 region, None) " }

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{ "id": "3515", "sentence": "Nuclear NF-ATp is a hallmark of unstimulated B cells from B-CLL patients .", "label": " ( protein: Nuclear NF-ATp, None) , ( cell type: unstimulated B cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Nuclear NF-ATp, None) , ( cell type: unstimulated B cells, None) " }

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{ "id": "3516", "sentence": "B lymphocytes from the peripheral blood of patients with chronic lymphocytic leukaemia ( CLL ) were analysed for the nuclear presence and DNA binding of a panel of transcription factors which are involved in the gene control of lymphoid cells .", "label": " ( cell type: lymphoid cells, None) , ( protein: transcription factors, None) , ( cell type: B lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphoid cells, None) , ( protein: transcription factors, None) , ( cell type: B lymphocytes, None) " }

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{ "id": "3517", "sentence": "The following transcription factors were studied: the Octamer factors Oct-1 and Oct-2 , members of the AP-1 factor family , NF-AT factors , in particular NF-ATp , and members of the Rel/NF-kB family .", "label": " ( protein: NF-AT factors, None) , ( protein: Octamer factors, None) , ( protein: transcription factors, None) , ( protein: NF-ATp, None) , ( protein: Oct-1, None) , ( protein: AP-1 factor family, None) , ( protein: Oct-2, None) , ( protein: Rel/NF-kB family, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT factors, None) , ( protein: Octamer factors, None) , ( protein: transcription factors, None) , ( protein: NF-ATp, None) , ( protein: Oct-1, None) , ( protein: AP-1 factor family, None) , ( protein: Oct-2, None) , ( protein: Rel/NF-kB family, None) " }

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{ "id": "3518", "sentence": "We show that the constitutive nuclear translocation of NF-ATp , a member of the growing family of NF-AT factors , is a hallmark of nonstimulated B cells from CLL patients that distinguishes B-CLL cells from 'normal' B lymphocytes .", "label": " ( protein: NF-ATp, None) , ( cell type: B-CLL cells, None) , ( cell type: B lymphocytes, None) , ( cell type: #$%#normal#$%# B lymphocytes, None) , ( protein: NF-AT factors, None) , ( cell type: nonstimulated B cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-ATp, None) , ( cell type: B-CLL cells, None) , ( cell type: B lymphocytes, None) , ( cell type: #$%#normal#$%# B lymphocytes, None) , ( protein: NF-AT factors, None) , ( cell type: nonstimulated B cells, None) " }

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{ "id": "3519", "sentence": "Constitutive nuclear appearance was also observed for NF-kB2/p52.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3520", "sentence": "Constitutive binding of further factor proteins to DNA, such as JunD , c-Fos and FosB , was detected in several patients whereas the localisation and DNA binding of other factors such as c-Jun , RelA/p65 and c-Rel was unaltered.", "label": " ( protein: c-Fos, None) , ( protein: FosB, None) , ( protein: c-Rel, None) , ( protein: c-Jun, None) , ( protein: factor proteins, None) , ( protein: RelA/p65, None) , ( protein: JunD, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c-Fos, None) , ( protein: FosB, None) , ( protein: c-Rel, None) , ( protein: c-Jun, None) , ( protein: factor proteins, None) , ( protein: RelA/p65, None) , ( protein: JunD, None) " }

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{ "id": "3521", "sentence": "It is remarkable that in B-CLL cells the nuclear appearance and DNA binding of specific transcription factors is dramatically affected whereas other members of the same factor family remained unaltered in these leukemic cells.", "label": " ( protein: factor family, None) , ( protein: transcription factors, None) , ( cell type: B-CLL cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: factor family, None) , ( protein: transcription factors, None) , ( cell type: B-CLL cells, None) " }

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{ "id": "3522", "sentence": "It remains to be shown which molecular events lead to the specific 'pre-activation' , i.e.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3523", "sentence": "constitutive nuclear translocation and DNA binding , of these members of NF-AT , NF-kB and AP-1 factor families .", "label": " ( protein: NF-kB, None) , ( protein: AP-1 factor families, None) , ( protein: NF-AT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kB, None) , ( protein: AP-1 factor families, None) , ( protein: NF-AT, None) " }

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{ "id": "3524", "sentence": "Naive (CD45RA+) T lymphocytes are more sensitive to oxidative stress-induced signals than memory (CD45RO+) cells .", "label": " ( cell type: Naive (CD45RA+) T lymphocytes, None) , ( cell type: memory (CD45RO+) cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: Naive (CD45RA+) T lymphocytes, None) , ( cell type: memory (CD45RO+) cells, None) " }

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{ "id": "3525", "sentence": "Formation of reactive oxygen intermediates ( ROI ) after oxidative stress has been shown to be an activation signal for T lymphocytes , e.g., expression of IL-2 and its receptor are induced.", "label": " ( protein: receptor, None) , ( protein: IL-2, None) , ( cell type: T lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: receptor, None) , ( protein: IL-2, None) , ( cell type: T lymphocytes, None) " }

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{ "id": "3526", "sentence": "These ROI -induced effects can, to a large extent, be attributed to the activation of the transcription factor NF-kappaB .", "label": " ( protein: transcription factor, None) , ( protein: NF-kappaB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor, None) , ( protein: NF-kappaB, None) " }

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{ "id": "3527", "sentence": "Now we have examined whether naive and memory T lymphocytes differ in their sensitivity to ROI -mediated signals .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3528", "sentence": "When CD45RA+ (naive) and CD45RO+ (memory) T lymphocytes were directly stimulated with H2O2 , NF-kappaB nuclear translocation was stronger in naive cells than in memory cells and it could be induced with lower doses.", "label": " ( cell type: memory cells, None) , ( protein: NF-kappaB, None) , ( cell type: CD45RA+ (naive), None) , ( cell type: CD45RO+ (memory) T lymphocytes, None) , ( cell type: naive cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: memory cells, None) , ( protein: NF-kappaB, None) , ( cell type: CD45RA+ (naive), None) , ( cell type: CD45RO+ (memory) T lymphocytes, None) , ( cell type: naive cells, None) " }

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{ "id": "3529", "sentence": "The composition of the induced nuclear NF-kappaB (levels of p50 and RelA proteins ) was similar in these cell types.", "label": " ( protein: p50, None) , ( protein: RelA proteins, None) , ( protein: nuclear NF-kappaB, None) , ( protein: NF-kappaB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p50, None) , ( protein: RelA proteins, None) , ( protein: nuclear NF-kappaB, None) , ( protein: NF-kappaB, None) " }

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{ "id": "3530", "sentence": "The magnitude and kinetics of intracellular ROI were similar, suggesting that there were no differences in ROI -forming mechanisms or antioxidative capacities .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3531", "sentence": "The probable regulatory point was the cytoplasmic IkappaB inhibitor : in CD45RA+ cells, H2O2 caused a more profound depression in the levels of IkappaB alpha .", "label": " ( protein: IkappaB, None) , ( protein: IkappaB alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IkappaB, None) , ( protein: IkappaB alpha, None) " }

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{ "id": "3532", "sentence": "These findings indicate that T cells representing different activation and/or differentiation stages can be differentially responsive to ROI -mediated signals .", "label": " ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) " }

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{ "id": "3533", "sentence": "Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression.", "label": " ( protein: NF-AT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT, None) " }

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{ "id": "3534", "sentence": "Cells need to distinguish between transient Ca2+ signals that induce events such as muscle contraction , secretion , adhesion and synaptic transmission , and sustained Ca2+ signals that are involved in cell proliferation and differentiation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3535", "sentence": "The latter class of events is blocked in lymphocytes by the immunosuppressive drugs cyclosporin A and FK506 , which inhibit calcineurin , a Ca2+ -activated serine/threonine phosphatase necessary for the nuclear import of NF-AT transcription factors .", "label": " ( protein: transcription factors, None) , ( protein: Ca2+ -activated serine/threonine phosphatase, None) , ( protein: NF-AT, None) , ( protein: calcineurin, None) , ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) , ( protein: Ca2+ -activated serine/threonine phosphatase, None) , ( protein: NF-AT, None) , ( protein: calcineurin, None) , ( cell type: lymphocytes, None) " }

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{ "id": "3536", "sentence": "Here we report that sustained high concentrations of Ca2+ , but not transient pulses , are required to maintain NF-AT transcription factors in the nucleus, where they participate in Ca2+ -dependent induction of genes required for lymphocyte activation and proliferation .", "label": " ( protein: NF-AT, None) , ( protein: transcription factors, None) , ( cell type: lymphocyte, None) , ( DNA: genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT, None) , ( protein: transcription factors, None) , ( cell type: lymphocyte, None) , ( DNA: genes, None) " }

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{ "id": "3537", "sentence": "Furthermore, overexpression and constitutive nuclear localization of NF-AT , but not Jun , Fos , NF-kappaB , Oct or Ets family members , renders the interleukin-2 enhancer in Jurkat T lymphocytes resistant to FK506 and cyclosporin A .", "label": " ( DNA: interleukin-2 enhancer, None) , ( protein: NF-AT, None) , ( cell line: Jurkat T lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: interleukin-2 enhancer, None) , ( protein: NF-AT, None) , ( cell line: Jurkat T lymphocytes, None) " }

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{ "id": "3538", "sentence": "Thus a primary effect of these immunosuppressive reagents is to control the subcellular localization of the NF-AT family of transcription factors .", "label": " ( protein: NF-AT, None) , ( protein: transcription factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT, None) , ( protein: transcription factors, None) " }

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{ "id": "3539", "sentence": "Autoregulation of the NF-kappa B transactivator RelA ( p65 ) by multiple cytoplasmic inhibitors containing ankyrin motifs .", "label": " ( protein: RelA, None) , ( protein: cytoplasmic inhibitors, None) , ( protein: NF-kappa B transactivator, None) , ( protein: ankyrin motifs, None) , ( protein: p65, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RelA, None) , ( protein: cytoplasmic inhibitors, None) , ( protein: NF-kappa B transactivator, None) , ( protein: ankyrin motifs, None) , ( protein: p65, None) , ( protein: NF-kappa B, None) " }

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{ "id": "3540", "sentence": "RelA ( p65 ) functions as the critical transactivating component of the heterodimeric p50- p65 NF-kappa B complex and contains a high-affinity binding site for its cytoplasmic inhibitor , I kappa B alpha .", "label": " ( protein: p65, None) , ( protein: p65, None) , ( protein: high-affinity binding site, None) , ( protein: NF-kappa B, None) , ( protein: heterodimeric p50- p65 NF-kappa B complex, None) , ( protein: cytoplasmic inhibitor, None) , ( protein: I kappa B alpha, None) , ( protein: RelA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p65, None) , ( protein: p65, None) , ( protein: high-affinity binding site, None) , ( protein: NF-kappa B, None) , ( protein: heterodimeric p50- p65 NF-kappa B complex, None) , ( protein: cytoplasmic inhibitor, None) , ( protein: I kappa B alpha, None) , ( protein: RelA, None) " }

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{ "id": "3541", "sentence": "After cellular activation, I kappa B alpha is rapidly degraded in concert with the induced nuclear translocation of NF-kappa B .", "label": " ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) " }

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{ "id": "3542", "sentence": "The present study demonstrates that tumor necrosis factor alpha -induced degradation of I kappa B alpha in human T cells is preceded by its rapid phosphorylation in vivo.", "label": " ( protein: tumor necrosis factor alpha, None) , ( cell type: human T cells, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tumor necrosis factor alpha, None) , ( cell type: human T cells, None) , ( protein: I kappa B alpha, None) " }

[]

{ "id": "3543", "sentence": "However, these effects on I kappa B alpha result in nuclear mobilization of only a fraction of the entire cytoplasmic pool of RelA .", "label": " ( protein: RelA, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RelA, None) , ( protein: I kappa B alpha, None) " }

[]

{ "id": "3544", "sentence": "Subsequent studies have revealed that (i) cytoplasmic RelA is stably associated not only with I kappa B alpha but also with other ankyrin motif-rich proteins including the products of the NF-kappa B2 (p100) and NF-kappa B1 (p105) genes ; (ii) in contrast to RelA -I kappa B alpha , RelA -p100 cytoplasmic complexes are not dissociated following tumor necrosis factor alpha activation; (iii) p100 functions as a potent inhibitor of RelA -mediated transcription in vivo; (iv) the interaction of RelA and p100 involves the conserved Rel homology domain of both proteins but not the nuclear localization signal of RelA , which is required for I kappa B alpha binding ; (v) p100 inhibition of RelA function requires the C-terminal ankyrin motif domain , which mediates cytoplasmic retention of RelA ; and (vi) as observed with I kappa B alpha , nuclear RelA stimulates p100 mRNA and protein expression .", "label": " ( protein: I kappa B alpha, None) , ( protein: conserved Rel homology domain, None) , ( protein: I kappa B alpha, None) , ( protein: C-terminal ankyrin motif domain, None) , ( protein: RelA, None) , ( protein: RelA, None) , ( protein: RelA, None) , ( protein: p100, None) , ( protein: -I kappa B alpha, None) , ( protein: nuclear localization signal, None) , ( protein: ankyrin motif-rich proteins, None) , ( protein: p100, None) , ( protein: cytoplasmic RelA, None) , ( protein: RelA -p100 cytoplasmic complexes, None) , ( protein: RelA, None) , ( protein: RelA, None) , ( protein: RelA, None) , ( protein: p100, None) , ( protein: p100, None) , ( RNA: p100 mRNA, None) , ( protein: I kappa B alpha, None) , ( protein: tumor necrosis factor alpha, None) , ( protein: RelA, None) , ( protein: RelA, None) , ( protein: RelA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I kappa B alpha, None) , ( protein: conserved Rel homology domain, None) , ( protein: I kappa B alpha, None) , ( protein: C-terminal ankyrin motif domain, None) , ( protein: RelA, None) , ( protein: RelA, None) , ( protein: RelA, None) , ( protein: p100, None) , ( protein: -I kappa B alpha, None) , ( protein: nuclear localization signal, None) , ( protein: ankyrin motif-rich proteins, None) , ( protein: p100, None) , ( protein: cytoplasmic RelA, None) , ( protein: RelA -p100 cytoplasmic complexes, None) , ( protein: RelA, None) , ( protein: RelA, None) , ( protein: RelA, None) , ( protein: p100, None) , ( protein: p100, None) , ( RNA: p100 mRNA, None) , ( protein: I kappa B alpha, None) , ( protein: tumor necrosis factor alpha, None) , ( protein: RelA, None) , ( protein: RelA, None) , ( protein: RelA, None) " }

[]

{ "id": "3545", "sentence": "These findings thus reveal the presence of a second inducible autoregulated inhibitory pathway that helps ensure the rapid but transient action of nuclear NF-kappa B .", "label": " ( protein: nuclear NF-kappa B, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear NF-kappa B, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "3546", "sentence": "Effects of CD45 on NF-kappa B .", "label": " ( protein: CD45, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD45, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "3547", "sentence": "Implications for replication of HIV-1 .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3548", "sentence": "Increased levels of replication of the HIV type 1 are observed after the activation of infected T cells through the TCR .", "label": " ( cell type: infected T cells, None) , ( protein: TCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: infected T cells, None) , ( protein: TCR, None) " }

[]

{ "id": "3549", "sentence": "However, anti- CD45 antibodies inhibit these effects in cells from infected individuals.", "label": " ( protein: CD45, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD45, None) " }

[]

{ "id": "3550", "sentence": "In this study, we examined interrelationships between CD45 and HIV-1 further.", "label": " ( protein: CD45, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD45, None) " }

[]

{ "id": "3551", "sentence": "We measured effects on the HIV-1 LTR in T cell lines that were stimulated with antibodies against CD45 and in those that lacked the expression of CD45 on their surfaces.", "label": " ( protein: CD45, None) , ( protein: CD45, None) , ( DNA: HIV-1 LTR, None) , ( cell line: T cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD45, None) , ( protein: CD45, None) , ( DNA: HIV-1 LTR, None) , ( cell line: T cell lines, None) " }

[]

{ "id": "3552", "sentence": "First, anti- CD45 antibodies did not affect basal but decreased activated levels of expression from the HIV-1 LTR .", "label": " ( DNA: HIV-1 LTR, None) , ( protein: anti- CD45 antibodies, None) , ( protein: CD45, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: HIV-1 LTR, None) , ( protein: anti- CD45 antibodies, None) , ( protein: CD45, None) " }

[]

{ "id": "3553", "sentence": "Second, T cells , which lack CD45 and cannot signal via the TCR , supported higher levels of viral replication and gene expression.", "label": " ( cell type: T cells, None) , ( protein: CD45, None) , ( protein: TCR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: CD45, None) , ( protein: TCR, None) " }

[]

{ "id": "3554", "sentence": "This was due to the presence of active NF-kappa B complexes in the nucleus of CD45 -T cells.", "label": " ( protein: NF-kappa B, None) , ( protein: NF-kappa B complexes, None) , ( protein: CD45, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: NF-kappa B complexes, None) , ( protein: CD45, None) " }

[]

{ "id": "3555", "sentence": "Additionally, infected T cells displayed lower levels of CD45 on their surfaces.", "label": " ( cell type: infected T cells, None) , ( protein: CD45, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: infected T cells, None) , ( protein: CD45, None) " }

[]

{ "id": "3556", "sentence": "Thus, CD45 plays an active role in the physiology of T cells and in the replication of HIV-1 .", "label": " ( cell type: T cells, None) , ( protein: CD45, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: CD45, None) " }

[]

{ "id": "3557", "sentence": "Calcineurin potentiates activation of the granulocyte-macrophage colony-stimulating factor gene in T cells : involvement of the conserved lymphokine element 0 .", "label": " ( cell type: T cells, None) , ( DNA: granulocyte-macrophage colony-stimulating factor gene, None) , ( protein: Calcineurin, None) , ( DNA: conserved lymphokine element 0, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( DNA: granulocyte-macrophage colony-stimulating factor gene, None) , ( protein: Calcineurin, None) , ( DNA: conserved lymphokine element 0, None) " }

[]

{ "id": "3558", "sentence": "Granulocyte-macrophage colony-stimulating factor ( GM-CSF ) and interleukin-2 ( IL-2 ) are produced by stimulation with phorbol-12-myristate acetate ( PMA ) and calcium ionophore (A23187) in human T cell leukemia Jurkat cells .", "label": " ( protein: interleukin-2, None) , ( cell line: human T cell leukemia Jurkat cells, None) , ( protein: Granulocyte-macrophage colony-stimulating factor, None) , ( protein: GM-CSF, None) , ( cell line: Jurkat cells, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin-2, None) , ( cell line: human T cell leukemia Jurkat cells, None) , ( protein: Granulocyte-macrophage colony-stimulating factor, None) , ( protein: GM-CSF, None) , ( cell line: Jurkat cells, None) , ( protein: IL-2, None) " }

[]

{ "id": "3559", "sentence": "The expression of GM-CSF and IL-2 is inhibited by immunosuppressive drugs such as cyclosporin A ( CsA ) and FK506 .", "label": " ( protein: GM-CSF, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GM-CSF, None) , ( protein: IL-2, None) " }

[]

{ "id": "3560", "sentence": "Earlier studies on the IL-2 gene expression showed that overexpression of calcineurin ( CN ), a Ca2+/calmodulin-dependent protein phosphatase , can stimulate transcription from the IL-2 promoter through the NF-AT-binding site .", "label": " ( DNA: IL-2 promoter, None) , ( DNA: NF-AT-binding site, None) , ( protein: Ca2+/calmodulin-dependent protein phosphatase, None) , ( protein: IL-2, None) , ( protein: CN, None) , ( protein: calcineurin, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IL-2 promoter, None) , ( DNA: NF-AT-binding site, None) , ( protein: Ca2+/calmodulin-dependent protein phosphatase, None) , ( protein: IL-2, None) , ( protein: CN, None) , ( protein: calcineurin, None) , ( protein: IL-2, None) " }

[]

{ "id": "3561", "sentence": "In this study, we obtained evidence that transfection of the cDNAs for CN A (catalytic) and CN B (regulatory) subunits also augments transcription from the GM-CSF promoter and recovers the transcription inhibited by CsA .", "label": " ( DNA: cDNAs, None) , ( protein: GM-CSF, None) , ( DNA: GM-CSF promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: cDNAs, None) , ( protein: GM-CSF, None) , ( DNA: GM-CSF promoter, None) " }

[]

{ "id": "3562", "sentence": "The constitutively active type of the CN A subunit , which lacks the auto-inhibitory and calmodulin-binding domains , acts in synergy with PMA to activate transcription from the GM-CSF promoter .", "label": " ( protein: calmodulin-binding domains, None) , ( DNA: GM-CSF promoter, None) , ( protein: CN A subunit, None) , ( protein: auto-inhibitory, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: calmodulin-binding domains, None) , ( DNA: GM-CSF promoter, None) , ( protein: CN A subunit, None) , ( protein: auto-inhibitory, None) " }

[]

{ "id": "3563", "sentence": "We also found that the active CN partially replaces calcium ionophore in synergy with PMA to induce expression of endogenous GM-CSF and IL-2 .", "label": " ( protein: CN, None) , ( protein: IL-2, None) , ( protein: GM-CSF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CN, None) , ( protein: IL-2, None) , ( protein: GM-CSF, None) " }

[]

{ "id": "3564", "sentence": "By multimerizing the regulatory elements of the GM-CSF promoter , we found that one of the target sites for the CN action is the conserved lymphokine element 0 ( CLE0 ), located at positions between -54 and -40 .", "label": " ( protein: GM-CSF, None) , ( DNA: GM-CSF promoter, None) , ( DNA: -54 and -40, None) , ( protein: CN, None) , ( DNA: CLE0, None) , ( DNA: regulatory elements, None) , ( DNA: target sites, None) , ( DNA: conserved lymphokine element 0, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GM-CSF, None) , ( DNA: GM-CSF promoter, None) , ( DNA: -54 and -40, None) , ( protein: CN, None) , ( DNA: CLE0, None) , ( DNA: regulatory elements, None) , ( DNA: target sites, None) , ( DNA: conserved lymphokine element 0, None) " }

[]

{ "id": "3565", "sentence": "Mobility shift assays showed that the CLE0 sequence has an AP1-binding site and is associated with an NF-AT-like factor , termed NF- CLE0 gamma .", "label": " ( protein: NF-AT-like factor, None) , ( protein: NF- CLE0 gamma, None) , ( DNA: CLE0, None) , ( DNA: CLE0, None) , ( DNA: AP1-binding site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT-like factor, None) , ( protein: NF- CLE0 gamma, None) , ( DNA: CLE0, None) , ( DNA: CLE0, None) , ( DNA: AP1-binding site, None) " }

[]

{ "id": "3566", "sentence": "NF- CLE0 gamma binding is induced by PMA /A23187 and is inhibited by treatment with CsA .", "label": " ( DNA: CLE0, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: CLE0, None) " }

[]

{ "id": "3567", "sentence": "These results suggest that CN is involved in the coordinated induction of the GM-CSF and IL-2 genes and that the CLE0 sequence of the GM-CSF gene is a functional analogue of the NF-AT-binding site in the IL-2 promoter , which mediates signals downstream of T cell activation .", "label": " ( DNA: GM-CSF gene, None) , ( protein: IL-2, None) , ( protein: GM-CSF, None) , ( DNA: IL-2 promoter, None) , ( DNA: NF-AT-binding site, None) , ( protein: CN, None) , ( DNA: CLE0 sequence, None) , ( DNA: CLE0, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: GM-CSF gene, None) , ( protein: IL-2, None) , ( protein: GM-CSF, None) , ( DNA: IL-2 promoter, None) , ( DNA: NF-AT-binding site, None) , ( protein: CN, None) , ( DNA: CLE0 sequence, None) , ( DNA: CLE0, None) " }

[]

{ "id": "3568", "sentence": "Alternate immune system targets for TCDD : lymphocyte stem cells and extrathymic T-cell development .", "label": " ( cell type: extrathymic T-cell, None) , ( cell type: lymphocyte stem cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: extrathymic T-cell, None) , ( cell type: lymphocyte stem cells, None) " }

[]

{ "id": "3569", "sentence": "We here summarize evidence that thymic atrophy induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin ( TCDD ) can be mediated, at least in part, by damage to extrathymic T-cell precursors in bone marrow and fetal liver .", "label": " ( cell type: extrathymic T-cell precursors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: extrathymic T-cell precursors, None) " }

[]

{ "id": "3570", "sentence": "This atrophy induction does not involve apoptotic mechanisms in thymocytes affected by the bcl-2 proto-oncogene .", "label": " ( DNA: bcl-2 proto-oncogene, None) , ( cell type: thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: bcl-2 proto-oncogene, None) , ( cell type: thymocytes, None) " }

[]

{ "id": "3571", "sentence": "TCDD mediates atrophy induction through its specific receptor (the AhR ) and not through effects on the estrogen receptor.", "label": " ( protein: AhR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AhR, None) " }

[]

{ "id": "3572", "sentence": "Both TCDD and estradiol induce extrathymic T-cell differentiation in the liver .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3573", "sentence": "These extrathymic T-cell populations include cells expressing elevated levels of V beta T-cell receptors that are normally deleted in thymic development .", "label": " ( cell type: extrathymic T-cell populations, None) , ( protein: V beta T-cell receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: extrathymic T-cell populations, None) , ( protein: V beta T-cell receptors, None) " }

[]

{ "id": "3574", "sentence": "Identification of Bcd , a novel proto-oncogene expressed in B-cells .", "label": " ( DNA: proto-oncogene, None) , ( DNA: Bcd, None) , ( cell type: B-cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: proto-oncogene, None) , ( DNA: Bcd, None) , ( cell type: B-cells, None) " }

[]

{ "id": "3575", "sentence": "A novel B-cell derived ( Bcd ) oncogene has been isolated from the peripheral blood lymphocytes of one B-cell chronic lymphocytic leukemia ( B-CLL ) patient using DNA transfer and a mouse tumorigenicity assay .", "label": " ( DNA: Bcd, None) , ( cell type: novel B-cell, None) , ( DNA: oncogene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Bcd, None) , ( cell type: novel B-cell, None) , ( DNA: oncogene, None) " }

[]

{ "id": "3576", "sentence": "The Bcd proto-oncogene was activated by a truncation in the 5' UTR .", "label": " ( DNA: proto-oncogene, None) , ( DNA: 5#$%# UTR, None) , ( DNA: Bcd, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: proto-oncogene, None) , ( DNA: 5#$%# UTR, None) , ( DNA: Bcd, None) " }

[]

{ "id": "3577", "sentence": "It predicts for two open reading frames ( ORFs ).", "label": " ( DNA: ORFs, None) , ( DNA: open reading frames, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: ORFs, None) , ( DNA: open reading frames, None) " }

[]

{ "id": "3578", "sentence": "ORF1 consists of 240 bp that would encode 80 amino acids , while the major ORF2 consists of 648 bp capable of coding for 216 amino acids .", "label": " ( DNA: major ORF2, None) , ( DNA: ORF1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: major ORF2, None) , ( DNA: ORF1, None) " }

[]

{ "id": "3579", "sentence": "Predicted peptide sequence of ORF2 contained a zinc finger domain which showed significant homology to GC box binding proteins BTEB2 and SP1 .", "label": " ( protein: BTEB2, None) , ( protein: GC box binding proteins, None) , ( protein: zinc finger domain, None) , ( protein: Predicted peptide sequence, None) , ( DNA: ORF2, None) , ( protein: SP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: BTEB2, None) , ( protein: GC box binding proteins, None) , ( protein: zinc finger domain, None) , ( protein: Predicted peptide sequence, None) , ( DNA: ORF2, None) , ( protein: SP1, None) " }

[]

{ "id": "3580", "sentence": "Transfection of an expression vector containing ORF2 but not full length cDNA was able to transform NIH3T3 cells and induce tumors in nude mice .", "label": " ( DNA: full length cDNA, None) , ( cell line: NIH3T3 cells, None) , ( DNA: ORF2, None) , ( DNA: expression vector, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: full length cDNA, None) , ( cell line: NIH3T3 cells, None) , ( DNA: ORF2, None) , ( DNA: expression vector, None) " }

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{ "id": "3581", "sentence": "Bcd mRNA transcripts of < or = 2.6 kb were selectively expressed in PBL and testis of healthy individuals .", "label": " ( cell line: PBL, None) , ( RNA: Bcd mRNA transcripts, None) , ( DNA: Bcd, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: PBL, None) , ( RNA: Bcd mRNA transcripts, None) , ( DNA: Bcd, None) " }

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{ "id": "3582", "sentence": "Within the PBL , Bcd gene expression was restricted to CD19+ B-cells and absent from CD14+ monocytes and T-cells .", "label": " ( DNA: Bcd, None) , ( cell type: B-cells, None) , ( cell type: CD19+ B-cells, None) , ( cell type: PBL, None) , ( cell type: T-cells, None) , ( cell type: CD14+ monocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Bcd, None) , ( cell type: B-cells, None) , ( cell type: CD19+ B-cells, None) , ( cell type: PBL, None) , ( cell type: T-cells, None) , ( cell type: CD14+ monocytes, None) " }

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{ "id": "3583", "sentence": "Bcd transcripts were detected in all normal PBL samples tested but not in several malignant human B-cell lines and not in 50% of B-cells from B-CLL patients .", "label": " ( cell type: PBL, None) , ( DNA: Bcd, None) , ( cell line: malignant human B-cell lines, None) , ( cell type: B-cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PBL, None) , ( DNA: Bcd, None) , ( cell line: malignant human B-cell lines, None) , ( cell type: B-cells, None) " }

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{ "id": "3584", "sentence": "However, stimulation of B-cells from B-CLL patients under conditions which induced differentiation into plasma cells was associated with induction of Bcd gene expression .", "label": " ( cell type: plasma cells, None) , ( DNA: Bcd, None) , ( cell type: B-cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: plasma cells, None) , ( DNA: Bcd, None) , ( cell type: B-cells, None) " }

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{ "id": "3585", "sentence": "The Bcd gene may therefore play an important role in B-cell growth and development .", "label": " ( DNA: Bcd, None) , ( DNA: Bcd gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Bcd, None) , ( DNA: Bcd gene, None) " }

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{ "id": "3586", "sentence": "A novel SP-1 site in the human interleukin-1 beta promoter confers preferential transcriptional activity in keratinocytes .", "label": " ( DNA: human interleukin-1 beta promoter, None) , ( DNA: novel SP-1 site, None) , ( cell type: keratinocytes, None) , ( DNA: SP-1 site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: human interleukin-1 beta promoter, None) , ( DNA: novel SP-1 site, None) , ( cell type: keratinocytes, None) , ( DNA: SP-1 site, None) " }

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{ "id": "3587", "sentence": "To investigate the mechanisms of transcriptional activation of interleukin-1beta ( IL-1beta ) in non-monocytic cells, we constructed a series of reporter plasmids with the bacterial chloramphenicol acetyltransferase gene linked to various parts of the human IL-1beta promoter and performed transient transfection experiments .", "label": " ( protein: IL-1beta, None) , ( DNA: IL-1beta promoter, None) , ( protein: interleukin-1beta, None) , ( protein: IL-1beta, None) , ( DNA: human IL-1beta promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-1beta, None) , ( DNA: IL-1beta promoter, None) , ( protein: interleukin-1beta, None) , ( protein: IL-1beta, None) , ( DNA: human IL-1beta promoter, None) " }

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{ "id": "3588", "sentence": "We identified a promoter segment that activates transcription most efficiently in keratinocytes .", "label": " ( cell type: keratinocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: keratinocytes, None) " }

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{ "id": "3589", "sentence": "Electrophoretic mobility shift assays ( EMSA ) with a 43-mer oligonucleotide derived from the functionally identified cis-acting element revealed specific complexes.", "label": " ( DNA: 43-mer oligonucleotide, None) , ( DNA: cis-acting element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: 43-mer oligonucleotide, None) , ( DNA: cis-acting element, None) " }

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{ "id": "3590", "sentence": "By competition analysis with transcription factor consensus sequence oligonucleotides and by immunosupershift , transcription factor SP-1 or a closely related protein was shown to bind to this regulatory element .", "label": " ( DNA: transcription factor consensus sequence oligonucleotides, None) , ( protein: transcription factor SP-1, None) , ( DNA: regulatory element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: transcription factor consensus sequence oligonucleotides, None) , ( protein: transcription factor SP-1, None) , ( DNA: regulatory element, None) " }

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{ "id": "3591", "sentence": "The closest match to the known SP-1 consensus sequence within the respective region is a TCCCCTCCCCT motif .", "label": " ( protein: SP-1, None) , ( DNA: TCCCCTCCCCT motif, None) , ( DNA: SP-1 consensus sequence, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: SP-1, None) , ( DNA: TCCCCTCCCCT motif, None) , ( DNA: SP-1 consensus sequence, None) " }

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{ "id": "3592", "sentence": "Mutation of this motif almost completely, and specifically, abolished the binding of two low-mobility complexes and led to a 95% decrease of constitutive transcriptional activation of a reporter construct IL-1beta (-170/+108).", "label": " ( protein: IL-1beta, None) , ( protein: low-mobility complexes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-1beta, None) , ( protein: low-mobility complexes, None) " }

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{ "id": "3593", "sentence": "Likewise, activation of this reporter construct by tumor necrosis factor-alpha depended on the SP-1 site .", "label": " ( protein: SP-1, None) , ( DNA: SP-1 site, None) , ( protein: tumor necrosis factor-alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: SP-1, None) , ( DNA: SP-1 site, None) , ( protein: tumor necrosis factor-alpha, None) " }

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{ "id": "3594", "sentence": "These observations suggest that a so-far-unrecognized SP-1 site in the human IL-1beta promoter may participate in the transcriptional regulation of this gene in keratinocytes .", "label": " ( DNA: IL-1beta promoter, None) , ( protein: SP-1, None) , ( cell type: keratinocytes, None) , ( DNA: human IL-1beta promoter, None) , ( protein: IL-1beta, None) , ( DNA: SP-1 site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IL-1beta promoter, None) , ( protein: SP-1, None) , ( cell type: keratinocytes, None) , ( DNA: human IL-1beta promoter, None) , ( protein: IL-1beta, None) , ( DNA: SP-1 site, None) " }

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{ "id": "3595", "sentence": "Expression of Egr-1 correlates with the transformed phenotype and the type of viral latency in EBV genome positive lymphoid cell lines .", "label": " ( cell line: EBV genome positive lymphoid cell lines, None) , ( protein: Egr-1, None) , ( DNA: EBV genome, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: EBV genome positive lymphoid cell lines, None) , ( protein: Egr-1, None) , ( DNA: EBV genome, None) " }

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{ "id": "3596", "sentence": "In this paper we have investigated the role of Egr-1 in B cell growth regulation by examining the gene expression in a panel of B cell lines , including both EBV genome negative and EBV carrying cell lines .", "label": " ( cell line: B cell lines, None) , ( DNA: EBV genome, None) , ( cell line: EBV carrying cell lines, None) , ( protein: Egr-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: B cell lines, None) , ( DNA: EBV genome, None) , ( cell line: EBV carrying cell lines, None) , ( protein: Egr-1, None) " }

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{ "id": "3597", "sentence": "Egr-1 expression correlates with the cellular phenotype and the specific pattern of viral latency established within the individual cell lines .", "label": " ( protein: Egr-1, None) , ( cell line: individual cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Egr-1, None) , ( cell line: individual cell lines, None) " }

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{ "id": "3598", "sentence": "Thus, constitutive activation of Egr-1 gene is invariably associated with unrestricted expression of viral latent genes in all group III EBV genome carrying cell lines .", "label": " ( cell line: group III EBV genome carrying cell lines, None) , ( DNA: EBV genome, None) , ( protein: Egr-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: group III EBV genome carrying cell lines, None) , ( DNA: EBV genome, None) , ( protein: Egr-1, None) " }

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{ "id": "3599", "sentence": "In contrast, Egr-1 expression is abrogated in group I Burkitt tumor cells , irrespective of the EBV genome carrying status.", "label": " ( DNA: EBV genome, None) , ( protein: Egr-1, None) , ( cell line: group I Burkitt tumor cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: EBV genome, None) , ( protein: Egr-1, None) , ( cell line: group I Burkitt tumor cells, None) " }