Datasets:

huy-nh-2000

/

instructUIE

like 0

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{ "id": "3700", "sentence": "Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells .", "label": " ( cell type: myeloid cells, None) , ( protein: interferon regulatory factor-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: myeloid cells, None) , ( protein: interferon regulatory factor-1, None) " }

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{ "id": "3701", "sentence": "All-trans-retinoic acid ( ATRA ) is the drug of choice in the treatment of acute promyelocytic leukemia ( APL ).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3702", "sentence": "ATRA induces both in vitro and in vivo differentiation of APL cells into mature granulocytes .", "label": " ( cell line: APL cells, None) , ( cell type: mature granulocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: APL cells, None) , ( cell type: mature granulocytes, None) " }

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{ "id": "3703", "sentence": "However, the molecular mechanisms involved in ATRA -dependent growth inhibition and cellular differentiation are not presently understood.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3704", "sentence": "The NB4 cell line , which is derived from the bone marrow of a patient with APL during relapse, can be used as a model system to study the growth and differentiation of APL cells .", "label": " ( cell line: APL cells, None) , ( cell line: NB4 cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: APL cells, None) , ( cell line: NB4 cell line, None) " }

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{ "id": "3705", "sentence": "Because interferon (IFN) regulatory factors ( IRF-1 and IRF-2 ) and other IFN-inducible gene products regulate cell growth , we analyzed the effects of ATRA on the expression of these genes.", "label": " ( protein: IFN-inducible gene products, None) , ( protein: IRF-1, None) , ( protein: IRF-2, None) , ( protein: interferon (IFN) regulatory factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IFN-inducible gene products, None) , ( protein: IRF-1, None) , ( protein: IRF-2, None) , ( protein: interferon (IFN) regulatory factors, None) " }

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{ "id": "3706", "sentence": "We show that ATRA directly activates IRF-1 gene expression , followed by activation of IRF-2 and 2'-5' oligoadenylate synthetase (OAS) gene expression with slower kinetics.", "label": " ( protein: 2#$%#-5#$%# oligoadenylate synthetase, None) , ( DNA: IRF-1 gene, None) , ( protein: IRF-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: 2#$%#-5#$%# oligoadenylate synthetase, None) , ( DNA: IRF-1 gene, None) , ( protein: IRF-2, None) " }

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{ "id": "3707", "sentence": "In addition to NB4 cells, ATRA also activated IRF-1 gene expression in HL-60 , U937 , and THP-1 cells , which all respond to ATRA by growth inhibition .", "label": " ( cell line: U937, None) , ( cell line: THP-1 cells, None) , ( DNA: IRF-1 gene, None) , ( cell line: HL-60, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: U937, None) , ( cell line: THP-1 cells, None) , ( DNA: IRF-1 gene, None) , ( cell line: HL-60, None) " }

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{ "id": "3708", "sentence": "A more than additive increase in IRF-1 gene expression was seen with ATRA and IFN-gamma in NB4 cells .", "label": " ( cell line: NB4 cells, None) , ( DNA: IRF-1 gene, None) , ( protein: IFN-gamma, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: NB4 cells, None) , ( DNA: IRF-1 gene, None) , ( protein: IFN-gamma, None) " }

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{ "id": "3709", "sentence": "ATRA did not activate nuclear factor kappa B or signal transducer and activator of transcription (STAT) activation pathways , suggesting that an alternate mechanism is involved in IRF-1 gene activation.", "label": " ( DNA: IRF-1 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IRF-1 gene, None) " }

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{ "id": "3710", "sentence": "The ATRA -induced expression of IRF-1 , an activator of transcription and repressor of transformation, may be one of the molecular mechanisms of ATRA -induced growth inhibition , and the basis for the synergistic actions of ATRA and IFNs in myeloid leukemia cells .", "label": " ( cell line: myeloid leukemia cells, None) , ( protein: IRF-1, None) , ( protein: IFNs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: myeloid leukemia cells, None) , ( protein: IRF-1, None) , ( protein: IFNs, None) " }

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{ "id": "3711", "sentence": "Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes .", "label": " ( cell type: T cells, None) , ( protein: NFAT1, None) , ( DNA: cytokine genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: NFAT1, None) , ( DNA: cytokine genes, None) " }

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{ "id": "3712", "sentence": "Transcription factors of the NFAT family play a key role in the transcription of cytokine genes and other genes during the immune response .", "label": " ( protein: NFAT family, None) , ( protein: Transcription factors, None) , ( DNA: cytokine genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NFAT family, None) , ( protein: Transcription factors, None) , ( DNA: cytokine genes, None) " }

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{ "id": "3713", "sentence": "We have identified two new isoforms of the transcription factor NFAT1 (previously termed NFATp ) that are the predominant isoforms expressed in murine and human T cells .", "label": " ( protein: NFAT1, None) , ( protein: transcription factor, None) , ( protein: NFATp, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NFAT1, None) , ( protein: transcription factor, None) , ( protein: NFATp, None) " }

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{ "id": "3714", "sentence": "When expressed in Jurkat T cells , recombinant NFAT1 is regulated, as expected, by the calmodulin-dependent phosphatase calcineurin , and its function is inhibited by the immunosuppressive agent cyclosporin A ( CsA ).", "label": " ( protein: calcineurin, None) , ( cell line: Jurkat T cells, None) , ( protein: NFAT1, None) , ( protein: calmodulin-dependent phosphatase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: calcineurin, None) , ( cell line: Jurkat T cells, None) , ( protein: NFAT1, None) , ( protein: calmodulin-dependent phosphatase, None) " }

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{ "id": "3715", "sentence": "Transactivation by recombinant NFAT1 in Jurkat T cells requires dual stimulation with ionomycin and phorbol 12-myristate 13-acetate ; this activity is potentiated by coexpression of constitutively active calcineurin and is inhibited by CsA .", "label": " ( protein: calcineurin, None) , ( cell line: Jurkat T cells, None) , ( protein: NFAT1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: calcineurin, None) , ( cell line: Jurkat T cells, None) , ( protein: NFAT1, None) " }

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{ "id": "3716", "sentence": "Immunocytochemical analysis indicates that recombinant NFAT1 localizes in the cytoplasm of transiently transfected T cells and translocates into the nucleus in a CsA -sensitive manner following ionomycin stimulation .", "label": " ( protein: NFAT1, None) , ( cell type: transiently transfected T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NFAT1, None) , ( cell type: transiently transfected T cells, None) " }

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{ "id": "3717", "sentence": "When expressed in COS cells , however, NFAT1 is capable of transactivation, but it is not regulated correctly: its subcellular localization and transcriptional function are not affected by stimulation of the COS cells with ionomycin and phorbol 12-myristate 13-acetate .", "label": " ( protein: NFAT1, None) , ( cell line: COS cells, None) , ( cell line: COS cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NFAT1, None) , ( cell line: COS cells, None) , ( cell line: COS cells, None) " }

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{ "id": "3718", "sentence": "Recombinant NFAT1 can mediate transcription of the interleukin-2 , interleukin-4, tumor necrosis factor alpha , and granulocyte-macrophage colony-stimulating factor promoters in T cells , suggesting that NFAT1 contributes to the CsA -sensitive transcription of these genes during the immune response .", "label": " ( protein: interleukin-2, None) , ( DNA: granulocyte-macrophage colony-stimulating factor promoters, None) , ( protein: tumor necrosis factor alpha, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( cell type: T cells, None) , ( protein: NFAT1, None) , ( protein: NFAT1, None) , ( DNA: genes, None) , ( DNA: promoters, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin-2, None) , ( DNA: granulocyte-macrophage colony-stimulating factor promoters, None) , ( protein: tumor necrosis factor alpha, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( cell type: T cells, None) , ( protein: NFAT1, None) , ( protein: NFAT1, None) , ( DNA: genes, None) , ( DNA: promoters, None) " }

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{ "id": "3719", "sentence": "Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130 .", "label": " ( protein: hTAFII130, None) , ( protein: TFIID, None) , ( protein: cell type-specific TFIID subunit, None) , ( protein: Human TAFII 105, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hTAFII130, None) , ( protein: TFIID, None) , ( protein: cell type-specific TFIID subunit, None) , ( protein: Human TAFII 105, None) " }

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{ "id": "3720", "sentence": "We previously characterized Drosophila and human TAF subunits that make up the core TFIID complex found in all cells.", "label": " ( protein: TFIID, None) , ( protein: TFIID complex, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TFIID, None) , ( protein: TFIID complex, None) " }

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{ "id": "3721", "sentence": "Here, we report that differentiated B cells contain a novel substoichiometric TAF of 105 kDa not found associated with TFIID isolated from other cell types.", "label": " ( protein: TFIID, None) , ( protein: TAF, None) , ( cell type: differentiated B cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TFIID, None) , ( protein: TAF, None) , ( cell type: differentiated B cells, None) " }

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{ "id": "3722", "sentence": "The cDNA encoding hTAFII105 reveals a highly conserved C-terminal domain shared by hTAFII130 and oTAFII110 , while the N-terminal coactivator domain has diverged significantly.", "label": " ( DNA: cDNA, None) , ( protein: C-terminal domain, None) , ( protein: hTAFII130, None) , ( protein: hTAFII105, None) , ( protein: N-terminal coactivator domain, None) , ( protein: oTAFII110, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: cDNA, None) , ( protein: C-terminal domain, None) , ( protein: hTAFII130, None) , ( protein: hTAFII105, None) , ( protein: N-terminal coactivator domain, None) , ( protein: oTAFII110, None) " }

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{ "id": "3723", "sentence": "All cells tested express TAFII105 mRNA , but only B cells contain significant levels of protein associated with TFIID .", "label": " ( cell type: B cells, None) , ( protein: TFIID, None) , ( RNA: TAFII105 mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B cells, None) , ( protein: TFIID, None) , ( RNA: TAFII105 mRNA, None) " }

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{ "id": "3724", "sentence": "Transient overexpression of hTAFII105 selectively squelches the transcription of some genes in B cells .", "label": " ( cell type: B cells, None) , ( protein: hTAFII105, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B cells, None) , ( protein: hTAFII105, None) " }

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{ "id": "3725", "sentence": "These properties suggest that TAFII105 is a cell type-specific subunit of TFIID that may be responsible for mediating transcription by a subset of activators in B cells .", "label": " ( protein: TAFII105, None) , ( protein: TFIID, None) , ( cell type: B cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TAFII105, None) , ( protein: TFIID, None) , ( cell type: B cells, None) " }

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{ "id": "3726", "sentence": "Interstitial deletion constitutes the major mechanism for loss of heterozygosity on chromosome 20q in polycythemia vera .", "label": " ( DNA: chromosome 20q, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: chromosome 20q, None) " }

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{ "id": "3727", "sentence": "An acquired deletion of the long arm of chromosome 20 is a recurrent abnormality in myeloproliferative disorders , particularly polycythemia vera and myelodysplastic syndromes .", "label": " ( DNA: long arm, None) , ( DNA: chromosome 20, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: long arm, None) , ( DNA: chromosome 20, None) " }

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{ "id": "3728", "sentence": "The association of 20q deletions with myeloid \"stem cell\" disorders suggests that the deletions mark the site of one or more genes, loss or inactivation of which plays a role in the regulation of normal hematopoietic progenitors .", "label": " ( cell type: normal hematopoietic progenitors, None) , ( DNA: 20q deletions, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: normal hematopoietic progenitors, None) , ( DNA: 20q deletions, None) " }

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{ "id": "3729", "sentence": "We have recently performed a detailed molecular analysis of 20q deletions in peripheral blood (PB) granulocytes and defined a commonly deleted region of 16 to 21 centimorgan ( cM ).", "label": " ( DNA: cM, None) , ( DNA: 20q deletions, None) , ( DNA: commonly deleted region, None) , ( cell type: peripheral blood (PB) granulocytes, None) , ( DNA: 16 to 21 centimorgan, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: cM, None) , ( DNA: 20q deletions, None) , ( DNA: commonly deleted region, None) , ( cell type: peripheral blood (PB) granulocytes, None) , ( DNA: 16 to 21 centimorgan, None) " }

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{ "id": "3730", "sentence": "To further reduce the size of the common deleted region we have searched for small deletions or mitotic recombination events , neither of which would be detected by conventional cytogenetics .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3731", "sentence": "We have studied 48 patients with polycythemia vera and four patients with idiopathic myelofibrosis .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3732", "sentence": "In each case, cytogenetic analysis had either failed or had shown no abnormalities of chromosome 20 .", "label": " ( DNA: chromosome 20, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: chromosome 20, None) " }

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{ "id": "3733", "sentence": "Seventeen microsatellite markers that span the common deleted region were used to search for loss of heterozygosity in granulocyte DNA .", "label": " ( DNA: microsatellite markers, None) , ( DNA: granulocyte DNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: microsatellite markers, None) , ( DNA: granulocyte DNA, None) " }

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{ "id": "3734", "sentence": "No instance of microsatellite instability was observed in a total of 880 comparisons of granulocyte and T-cell DNA .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3735", "sentence": "Granulocyte DNA from four patients exhibited allele loss on 20q .", "label": " ( DNA: Granulocyte DNA, None) , ( DNA: 20q, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Granulocyte DNA, None) , ( DNA: 20q, None) " }

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{ "id": "3736", "sentence": "In each case the allele loss was caused by an interstitial deletion because heterozygosity at distal markers was retained and because quantitative Southern blotting demonstrated hemizygosity .", "label": " ( DNA: distal markers, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: distal markers, None) " }

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{ "id": "3737", "sentence": "Loss of heterozygosity in PB granulocytes would be masked by the presence of significant numbers of normal granulocytes not derived from the malignant clone .", "label": " ( cell type: PB granulocytes, None) , ( cell line: malignant clone, None) , ( cell type: normal granulocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PB granulocytes, None) , ( cell line: malignant clone, None) , ( cell type: normal granulocytes, None) " }

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{ "id": "3738", "sentence": "Therefore, the human androgen receptor assay ( HUMARA ) was used to determine granulocyte clonality.", "label": " ( protein: human androgen receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: human androgen receptor, None) " }

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{ "id": "3739", "sentence": "In 21 of 27 informative female patients the majority of the granulocytes were clonally derived.", "label": " ( cell type: granulocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: granulocytes, None) " }

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{ "id": "3740", "sentence": "In 5 patients the granulocytes appeared polyclonal and in 1 patient unilateral X inactivation was observed in both granulocytes and T cells .", "label": " ( cell type: T cells, None) , ( cell type: granulocytes, None) , ( cell type: granulocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( cell type: granulocytes, None) , ( cell type: granulocytes, None) " }

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{ "id": "3741", "sentence": "These results show that, in the vast majority of patients presented here, the failure to detect loss of heterozygosity cannot be attributed to the presence of normal polyclonal granulocytes .", "label": " ( cell line: normal polyclonal granulocytes, None) , ( cell type: granulocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: normal polyclonal granulocytes, None) , ( cell type: granulocytes, None) " }

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{ "id": "3742", "sentence": "Our results therefore show that allele loss on chromosome 20q in polycythemia vera does not commonly involve mitotic recombination or chromosome loss and that microsatellite instability is a rare event in this disorder.", "label": " ( DNA: chromosome, None) , ( DNA: chromosome 20q, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: chromosome, None) , ( DNA: chromosome 20q, None) " }

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{ "id": "3743", "sentence": "Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein .", "label": " ( protein: Interleukin-6, None) , ( protein: retinoblastoma protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Interleukin-6, None) , ( protein: retinoblastoma protein, None) " }

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{ "id": "3744", "sentence": "Interleukin-6 ( IL-6 ) mediates autocrine and paracrine growth of multiple myeloma (MM) cells and inhibits tumor cell apoptosis .", "label": " ( protein: Interleukin-6, None) , ( protein: IL-6, None) , ( cell line: multiple myeloma (MM) cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Interleukin-6, None) , ( protein: IL-6, None) , ( cell line: multiple myeloma (MM) cells, None) " }

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{ "id": "3745", "sentence": "Abnormalities of retinoblastoma protein ( pRB ) and mutations of RB gene have been reported in up to 70% of MM patients and 80% of MM-derived cell lines .", "label": " ( protein: retinoblastoma protein, None) , ( cell line: MM-derived cell lines, None) , ( protein: pRB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: retinoblastoma protein, None) , ( cell line: MM-derived cell lines, None) , ( protein: pRB, None) " }

[]

{ "id": "3746", "sentence": "Because dephosphorylated (activated) pRB blocks transition from G1 to S phase of the cell cycle whereas phosphorylated (inactivated) pRB releases this growth arrest, we characterized the role of pRB in IL-6 -mediated MM cell growth .", "label": " ( protein: dephosphorylated (activated) pRB, None) , ( protein: pRB, None) , ( protein: IL-6, None) , ( protein: pRB, None) , ( protein: phosphorylated (inactivated) pRB, None) , ( protein: pRB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: dephosphorylated (activated) pRB, None) , ( protein: pRB, None) , ( protein: IL-6, None) , ( protein: pRB, None) , ( protein: phosphorylated (inactivated) pRB, None) , ( protein: pRB, None) " }

[]

{ "id": "3747", "sentence": "Both phosphorylated and dephosphorylated pRB were expressed in all serum-starved MM patient cells and MM-derived cell lines , but pRB was predominantly in its phosphorylated form.", "label": " ( protein: pRB, None) , ( cell line: MM-derived cell lines, None) , ( protein: pRB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: pRB, None) , ( cell line: MM-derived cell lines, None) , ( protein: pRB, None) " }

[]

{ "id": "3748", "sentence": "In MM cells that proliferated in response to IL-6 , exogenous IL-6 downregulated dephosphorylated pRB and decreased dephosphorylated pRB -E2F complexes .", "label": " ( protein: IL-6, None) , ( protein: dephosphorylated pRB, None) , ( protein: IL-6, None) , ( cell line: MM cells, None) , ( protein: pRB -E2F complexes, None) , ( protein: pRB, None) , ( protein: pRB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-6, None) , ( protein: dephosphorylated pRB, None) , ( protein: IL-6, None) , ( cell line: MM cells, None) , ( protein: pRB -E2F complexes, None) , ( protein: pRB, None) , ( protein: pRB, None) " }

[]

{ "id": "3749", "sentence": "Importantly, culture of MM cells with RB antisense , but not RB sense, oligonucleotide ( ODN ) triggered IL-6 secretion and proliferation in MM cells ; however, proliferation was only partially inhibited by neutralizing anti- IL-6 monoclonal antibody ( MoAb ).", "label": " ( protein: IL-6, None) , ( protein: anti- IL-6 monoclonal antibody, None) , ( cell line: MM cells, None) , ( protein: IL-6, None) , ( cell line: MM cells, None) , ( protein: MoAb, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-6, None) , ( protein: anti- IL-6 monoclonal antibody, None) , ( cell line: MM cells, None) , ( protein: IL-6, None) , ( cell line: MM cells, None) , ( protein: MoAb, None) " }

[]

{ "id": "3750", "sentence": "In contrast to MM cells , normal splenic B cells express dephosphorylated pRB .", "label": " ( cell type: splenic B cells, None) , ( protein: dephosphorylated pRB, None) , ( protein: pRB, None) , ( cell line: MM cells, None) , ( cell type: B cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: splenic B cells, None) , ( protein: dephosphorylated pRB, None) , ( protein: pRB, None) , ( cell line: MM cells, None) , ( cell type: B cells, None) " }

[]

{ "id": "3751", "sentence": "Although CD40 ligand ( CD40L ) triggers a shift from dephosphorylated to phosphorylated pRB and proliferation of B cells , the addition of exogenous IL-6 to CD40L -treated B cells does not alter either pRB or proliferation, as observed in MM cells .", "label": " ( protein: CD40 ligand, None) , ( cell type: B cells, None) , ( protein: IL-6, None) , ( protein: pRB, None) , ( cell type: B cells, None) , ( protein: CD40L, None) , ( cell line: MM cells, None) , ( protein: pRB, None) , ( protein: CD40L, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD40 ligand, None) , ( cell type: B cells, None) , ( protein: IL-6, None) , ( protein: pRB, None) , ( cell type: B cells, None) , ( protein: CD40L, None) , ( cell line: MM cells, None) , ( protein: pRB, None) , ( protein: CD40L, None) " }

[]

{ "id": "3752", "sentence": "These results suggest that phosphorylated pRB is constitutively expressed in MM cells and that IL-6 further shifts pRB from its dephosphorylated to its phosphorylated form, thereby promoting MM cell growth via two mechanisms; by decreasing the amount of E2F bound by dephosphorylated pRB due to reduced dephosphorylated pRB , thereby releasing growth arrest; and by upregulating IL-6 secretion by MM cells and related IL-6 -mediated autocrine tumor cell growth .", "label": " ( protein: pRB, None) , ( cell line: MM cells, None) , ( protein: pRB, None) , ( protein: phosphorylated pRB, None) , ( protein: IL-6, None) , ( protein: dephosphorylated pRB, None) , ( protein: dephosphorylated pRB, None) , ( protein: IL-6, None) , ( protein: IL-6, None) , ( cell line: MM cells, None) , ( protein: pRB, None) , ( protein: pRB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: pRB, None) , ( cell line: MM cells, None) , ( protein: pRB, None) , ( protein: phosphorylated pRB, None) , ( protein: IL-6, None) , ( protein: dephosphorylated pRB, None) , ( protein: dephosphorylated pRB, None) , ( protein: IL-6, None) , ( protein: IL-6, None) , ( cell line: MM cells, None) , ( protein: pRB, None) , ( protein: pRB, None) " }

[]

{ "id": "3753", "sentence": "Soluble factors secreted by activated T-lymphocytes modulate the transcription of the immunosuppressive cytokine TGF-beta 2 in glial cells .", "label": " ( cell type: glial cells, None) , ( cell type: activated T-lymphocytes, None) , ( protein: immunosuppressive cytokine, None) , ( protein: Soluble factors, None) , ( protein: TGF-beta 2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: glial cells, None) , ( cell type: activated T-lymphocytes, None) , ( protein: immunosuppressive cytokine, None) , ( protein: Soluble factors, None) , ( protein: TGF-beta 2, None) " }

[]

{ "id": "3754", "sentence": "Coordination of the immune response to injury or disease in the brain is postulated to involve bi-directional discourse between the immune system and the central nervous system .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3755", "sentence": "This cross communication involves soluble mediators, including various growth factors , cytokines , and neuropeptides .", "label": " ( protein: cytokines, None) , ( protein: growth factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokines, None) , ( protein: growth factors, None) " }

[]

{ "id": "3756", "sentence": "In this report, we demonstrate that the supernatant from activated T-lymphocytes is able to induce the transcription of a potent cytokine , TGF-beta 2 in glial cells .", "label": " ( protein: cytokine, None) , ( cell type: activated T-lymphocytes, None) , ( protein: TGF-beta 2, None) , ( cell type: glial cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine, None) , ( cell type: activated T-lymphocytes, None) , ( protein: TGF-beta 2, None) , ( cell type: glial cells, None) " }

[]

{ "id": "3757", "sentence": "The activating stimulus invokes signaling mechanisms distinct from known kinase or protease pathways .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "3758", "sentence": "Activation of TGF-beta 2 transcription correlates with the loss of binding activity for an 80 kDA glial labile repressor protein , GLRP , to a responsive region within the TFG-beta 2 promoter .", "label": " ( protein: TGF-beta 2, None) , ( protein: GLRP, None) , ( DNA: TFG-beta 2 promoter, None) , ( protein: 80 kDA glial labile repressor protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TGF-beta 2, None) , ( protein: GLRP, None) , ( DNA: TFG-beta 2 promoter, None) , ( protein: 80 kDA glial labile repressor protein, None) " }

[]

{ "id": "3759", "sentence": "Although GLRP shares some characteristics with the inducible transcription factor AP-1 , it appears to be distinct from known AP-1 family members .", "label": " ( protein: AP-1, None) , ( protein: transcription factor, None) , ( protein: GLRP, None) , ( protein: AP-1 family members, None) , ( protein: AP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: AP-1, None) , ( protein: transcription factor, None) , ( protein: GLRP, None) , ( protein: AP-1 family members, None) , ( protein: AP-1, None) " }

[]

{ "id": "3760", "sentence": "These data along with previous observations demonstrating the potent immunosuppressive activity of TGF-beta 2 , support a model for a feedback mechanism between the activated T-lymphocytes and astrocytes via TGF-beta 2 to regulate the immune response .", "label": " ( cell type: astrocytes, None) , ( protein: TGF-beta 2, None) , ( cell type: T-lymphocytes, None) , ( protein: TGF-beta 2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: astrocytes, None) , ( protein: TGF-beta 2, None) , ( cell type: T-lymphocytes, None) , ( protein: TGF-beta 2, None) " }

[]

{ "id": "3761", "sentence": "Various modes of basic helix-loop-helix protein -mediated regulation of murine leukemia virus transcription in lymphoid cell lines .", "label": " ( protein: basic helix-loop-helix protein, None) , ( cell line: lymphoid cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: basic helix-loop-helix protein, None) , ( cell line: lymphoid cell lines, None) " }

[]

{ "id": "3762", "sentence": "The transcriptionally regulatory regions of the lymphomagenic Akv and SL3-3 murine leukemia retroviruses ( MLVs ) contain two types of E-box consensus motifs , CAGATG .", "label": " ( DNA: transcriptionally regulatory regions, None) , ( DNA: E-box consensus motifs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: transcriptionally regulatory regions, None) , ( DNA: E-box consensus motifs, None) " }

[]

{ "id": "3763", "sentence": "One type, EA/S , is located in the upstream promoter region , and the other, E(gre) , is located in a tandem repeat with enhancer properties .", "label": " ( DNA: tandem repeat, None) , ( DNA: E(gre), None) , ( DNA: upstream promoter region, None) , ( DNA: EA/S, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: tandem repeat, None) , ( DNA: E(gre), None) , ( DNA: upstream promoter region, None) , ( DNA: EA/S, None) " }

[]

{ "id": "3764", "sentence": "We have examined the requirements of the individual E-boxes in MLV transcriptional regulation .", "label": " ( DNA: E-boxes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: E-boxes, None) " }

[]

{ "id": "3765", "sentence": "In lymphoid cell lines only, the E(gre) -binding protein complexes included ALF1 or HEB and E2A basic helix-loop-helix proteins .", "label": " ( protein: ALF1, None) , ( cell line: lymphoid cell lines, None) , ( protein: basic helix-loop-helix proteins, None) , ( protein: E2A basic helix-loop-helix proteins, None) , ( DNA: E(gre), None) , ( protein: E(gre) -binding protein complexes, None) , ( protein: HEB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ALF1, None) , ( cell line: lymphoid cell lines, None) , ( protein: basic helix-loop-helix proteins, None) , ( protein: E2A basic helix-loop-helix proteins, None) , ( DNA: E(gre), None) , ( protein: E(gre) -binding protein complexes, None) , ( protein: HEB, None) " }

[]

{ "id": "3766", "sentence": "Ectopic ALF1 and E2A proteins required intact E(gre) motifs for mediating transcriptional activation .", "label": " ( DNA: E(gre), None) , ( protein: E2A proteins, None) , ( DNA: E(gre) motifs, None) , ( protein: ALF1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: E(gre), None) , ( protein: E2A proteins, None) , ( DNA: E(gre) motifs, None) , ( protein: ALF1, None) " }

[]

{ "id": "3767", "sentence": "ALF1 transactivated transcription of Akv MLV through the two E(gre) motifs equally, whereas E2A protein required the promoter-proximal E(gre) motif.", "label": " ( DNA: E(gre), None) , ( DNA: E(gre) motifs, None) , ( DNA: E(gre), None) , ( protein: E2A protein, None) , ( protein: ALF1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: E(gre), None) , ( DNA: E(gre) motifs, None) , ( DNA: E(gre), None) , ( protein: E2A protein, None) , ( protein: ALF1, None) " }

[]

{ "id": "3768", "sentence": "In T- and B- cell lines , the E(gre) motifs were of major importance for Akv MLV transcriptional activity , while the EA/S motif had some effect.", "label": " ( DNA: E(gre), None) , ( DNA: EA/S motif, None) , ( DNA: E(gre) motifs, None) , ( DNA: EA/S, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: E(gre), None) , ( DNA: EA/S motif, None) , ( DNA: E(gre) motifs, None) , ( DNA: EA/S, None) " }

[]

{ "id": "3769", "sentence": "In contrast, neither E(gre) nor EA/S motifs contributed pronouncedly to Akv MLV transcription in NIH 3T3 cells lacking DNA-binding ALF1 or HEB and E2A proteins .", "label": " ( protein: E2A proteins, None) , ( protein: ALF1, None) , ( protein: HEB, None) , ( DNA: E(gre), None) , ( DNA: EA/S, None) , ( DNA: EA/S motifs, None) , ( cell line: NIH 3T3 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: E2A proteins, None) , ( protein: ALF1, None) , ( protein: HEB, None) , ( DNA: E(gre), None) , ( DNA: EA/S, None) , ( DNA: EA/S motifs, None) , ( cell line: NIH 3T3 cells, None) " }

[]

{ "id": "3770", "sentence": "The Id1 protein was found to repress ALF1 activity in vitro and in vivo.", "label": " ( protein: ALF1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ALF1, None) " }

[]

{ "id": "3771", "sentence": "Moreover, ectopic Id1 repressed E(gre) -directed but not EA/S -directed MLV transcription in lymphoid cell lines .", "label": " ( cell line: lymphoid cell lines, None) , ( DNA: EA/S, None) , ( DNA: E(gre), None) , ( protein: ectopic Id1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: lymphoid cell lines, None) , ( DNA: EA/S, None) , ( DNA: E(gre), None) , ( protein: ectopic Id1, None) " }

[]

{ "id": "3772", "sentence": "In conclusion, E(gre) motifs and interacting basic helix-loop-helix proteins are important determinants for MLV transcriptional activity in lymphocytic cell lines .", "label": " ( protein: basic helix-loop-helix proteins, None) , ( cell line: lymphocytic cell lines, None) , ( DNA: E(gre), None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: basic helix-loop-helix proteins, None) , ( cell line: lymphocytic cell lines, None) , ( DNA: E(gre), None) " }

[]

{ "id": "3773", "sentence": "Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor .", "label": " ( protein: E2A-HLF chimaeric transcription factor, None) , ( protein: transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: E2A-HLF chimaeric transcription factor, None) , ( protein: transcription factor, None) " }

[]

{ "id": "3774", "sentence": "The E2A-HLF (for hepatic leukaemia factor) fusion gene , formed by action of the t(17;19) (q22;p13) chromosomal translocation , drives the leukaemic transformation of early B-cell precursors , but the mechanism of this activity remains unknown.", "label": " ( DNA: t(17;19) (q22;p13), None) , ( cell type: B-cell precursors, None) , ( protein: E2A-HLF, None) , ( DNA: E2A-HLF (for hepatic leukaemia factor) fusion gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: t(17;19) (q22;p13), None) , ( cell type: B-cell precursors, None) , ( protein: E2A-HLF, None) , ( DNA: E2A-HLF (for hepatic leukaemia factor) fusion gene, None) " }

[]

{ "id": "3775", "sentence": "Here we report that human leukaemia cells carrying the translocation t(17;19) rapidly died by apoptosis when programmed to express a dominant-negative suppressor of the fusion protein E2A-HLF , indicating that the chimaeric oncoprotein probably affects cell survival rather than cell growth .", "label": " ( DNA: t(17;19), None) , ( protein: E2A-HLF, None) , ( protein: chimaeric oncoprotein, None) , ( cell type: human leukaemia cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: t(17;19), None) , ( protein: E2A-HLF, None) , ( protein: chimaeric oncoprotein, None) , ( cell type: human leukaemia cells, None) " }

[]

{ "id": "3776", "sentence": "Moreover, when introduced into murine pro-B lymphocytes , the oncogenic E2A-HLF fusion protein reversed both interleukin-3-dependent and p53-mediated apoptosis .", "label": " ( cell line: murine pro-B lymphocytes, None) , ( protein: E2A-HLF, None) , ( protein: oncogenic E2A-HLF fusion protein, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: murine pro-B lymphocytes, None) , ( protein: E2A-HLF, None) , ( protein: oncogenic E2A-HLF fusion protein, None) " }

[]

{ "id": "3777", "sentence": "The close homology of the basic region/leucine zipper ( bZIP ) DNA-binding and dimerization domain of HLF to that of the CES-2 cell-death specification protein of Caenorhabditis elegans suggests a model of leukaemogenesis in which E2A-HLF blocks an early step within an evolutionarily conserved cell-death pathway .", "label": " ( protein: HLF, None) , ( protein: dimerization domain, None) , ( protein: bZIP, None) , ( protein: CES-2 cell-death specification protein, None) , ( protein: E2A-HLF, None) , ( protein: basic region/leucine zipper, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HLF, None) , ( protein: dimerization domain, None) , ( protein: bZIP, None) , ( protein: CES-2 cell-death specification protein, None) , ( protein: E2A-HLF, None) , ( protein: basic region/leucine zipper, None) " }

[]

{ "id": "3778", "sentence": "The role of early growth response gene 1 ( egr-1 ) in regulation of the immune response .", "label": " ( DNA: egr-1, None) , ( DNA: early growth response gene 1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: egr-1, None) , ( DNA: early growth response gene 1, None) " }

[]

{ "id": "3779", "sentence": "The induction of immediate early genes in cells of the immune system is critical to determining the ultimate outcome of exposure to antigen.", "label": " ( DNA: immediate early genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: immediate early genes, None) " }

[]

{ "id": "3780", "sentence": "The importance of many of these genes relates to the role their transcription factor products play in dictating patterns of expression of downstream, function-related genes .", "label": " ( DNA: function-related genes, None) , ( protein: transcription factor products, None) , ( protein: transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: function-related genes, None) , ( protein: transcription factor products, None) , ( protein: transcription factor, None) " }

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{ "id": "3781", "sentence": "Evidence from several systems indicates that the immediate early gene , egr-1 may be of particular importance in the immune system .", "label": " ( DNA: immediate early gene, None) , ( DNA: egr-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: immediate early gene, None) , ( DNA: egr-1, None) " }

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{ "id": "3782", "sentence": "Recently, the egr-1 promoter has been shown to be highly responsive to the diverse biochemical signals generated by antigen and cytokines in cells of the immune system .", "label": " ( DNA: egr-1, None) , ( DNA: egr-1 promoter, None) , ( protein: cytokines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: egr-1, None) , ( DNA: egr-1 promoter, None) , ( protein: cytokines, None) " }

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{ "id": "3783", "sentence": "Furthermore, an important role for egr-1 in determining the differentiation pathway of myeloid cell precursors has been recently elaborated.", "label": " ( DNA: egr-1, None) , ( cell type: myeloid cell precursors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: egr-1, None) , ( cell type: myeloid cell precursors, None) " }

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{ "id": "3784", "sentence": "Finally, potential targets of regulation by the zinc-finger transcription factor encoded by egr-1 include the interleukin-2 , CD44 , ICAM-1 , and tumor necrosis factor genes .", "label": " ( protein: transcription factor, None) , ( DNA: egr-1, None) , ( protein: zinc-finger transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor, None) , ( DNA: egr-1, None) , ( protein: zinc-finger transcription factor, None) " }

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{ "id": "3785", "sentence": "The role of egr-1 in regulation of the immune response will be discussed in the context of these recent studies.", "label": " ( DNA: egr-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: egr-1, None) " }

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{ "id": "3786", "sentence": "Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3787", "sentence": "Vaccination with synthetic peptides representing cytotoxic T lymphocyte (CTL) epitopes can lead to a protective CTL-mediated immunity against tumors or viruses .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3788", "sentence": "We now report that vaccination with a CTL epitope derived from the human adenovirus type 5 E1A-region ( Ad5E1A234-243 ), which can serve as a target for tumor-eradicating CTL , enhances rather than inhibits the growth of Ad5E1A-expressing tumors .", "label": " ( DNA: Ad5E1A234-243, None) , ( DNA: human adenovirus type 5 E1A-region, None) , ( cell type: tumor-eradicating CTL, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Ad5E1A234-243, None) , ( DNA: human adenovirus type 5 E1A-region, None) , ( cell type: tumor-eradicating CTL, None) " }

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{ "id": "3789", "sentence": "This adverse effect of peptide vaccination was rapidly evoked, required low doses of peptide (10 micrograms), and was achieved by a mode of peptide delivery that induces protective T-cell-mediated immunity in other models.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3790", "sentence": "Ad5E1A -specific CTL activity could no longer be isolated from mice after injection of Ad5E1A-peptide , indicating that tolerization of Ad5E1A -specific CTL activity causes the enhanced tumor outgrowth .", "label": " ( protein: Ad5E1A, None) , ( protein: Ad5E1A, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Ad5E1A, None) , ( protein: Ad5E1A, None) " }

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{ "id": "3791", "sentence": "In contrast to peptide vaccination , immunization with adenovirus, expressing Ad5E1A , induced Ad5E1A -specific immunity and prevented the outgrowth of Ad5E1A -expressing tumors .", "label": " ( protein: Ad5E1A, None) , ( protein: Ad5E1A, None) , ( protein: Ad5E1A, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Ad5E1A, None) , ( protein: Ad5E1A, None) , ( protein: Ad5E1A, None) " }

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{ "id": "3792", "sentence": "These results show that immunization with synthetic peptides can lead to the elimination of anti-tumor CTL responses .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3793", "sentence": "These findings are important for the design of safe peptide -based vaccines against tumors , allogeneic organ transplants , and T-cell-mediated autoimmune diseases .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "3794", "sentence": "[ NGFI-B/nur77 family involved in T-cell apoptosis ]", "label": " ( protein: NGFI-B/nur77 family, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NGFI-B/nur77 family, None) " }

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{ "id": "3795", "sentence": "NGFI-B/nur77 is a member of the steroid receptor superfamily .", "label": " ( protein: steroid receptor superfamily, None) , ( protein: NGFI-B/nur77, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: steroid receptor superfamily, None) , ( protein: NGFI-B/nur77, None) " }

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{ "id": "3796", "sentence": "NGFI-B/nur77 and its related genes constitute a family and the NGFI-B/nur77 family consists of three subtypes, named nur77 alpha , nur77 beta , nur77 gamma .", "label": " ( protein: NGFI-B/nur77 family, None) , ( protein: nur77 gamma, None) , ( protein: nur77 beta, None) , ( protein: nur77 alpha, None) , ( protein: NGFI-B/nur77, None) , ( protein: NGFI-B/nur77, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NGFI-B/nur77 family, None) , ( protein: nur77 gamma, None) , ( protein: nur77 beta, None) , ( protein: nur77 alpha, None) , ( protein: NGFI-B/nur77, None) , ( protein: NGFI-B/nur77, None) " }

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{ "id": "3797", "sentence": "We cloned human nur77 beta cDNA , called TINUR .", "label": " ( DNA: TINUR, None) , ( DNA: nur77 beta cDNA, None) , ( protein: nur77 beta, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: TINUR, None) , ( DNA: nur77 beta cDNA, None) , ( protein: nur77 beta, None) " }

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{ "id": "3798", "sentence": "Although NGFI-B/nur77 is essential for TCR-mediated apoptosis in T-cell hybridomas , the reports on nur77 knock-out mice and nur77 dominant negative transgenic mice suggest that there is a functional redundancy among NGFI-B/nur77 family .", "label": " ( protein: NGFI-B/nur77, None) , ( protein: T-cell hybridomas, None) , ( protein: NGFI-B/nur77 family, None) , ( protein: NGFI-B/nur77, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NGFI-B/nur77, None) , ( protein: T-cell hybridomas, None) , ( protein: NGFI-B/nur77 family, None) , ( protein: NGFI-B/nur77, None) " }

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{ "id": "3799", "sentence": "NGFI-B/nur77 binds to the response element by monomer or heterodimer with retinoid X receptor ( RXR ).", "label": " ( DNA: response element, None) , ( protein: retinoid X receptor, None) , ( protein: RXR, None) , ( protein: NGFI-B/nur77, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: response element, None) , ( protein: retinoid X receptor, None) , ( protein: RXR, None) , ( protein: NGFI-B/nur77, None) " }