Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "2600", "sentence": "No evidence for the expression of the progesterone receptor on peripheral blood lymphocytes during pregnancy [see comments]", "label": " ( cell type: peripheral blood lymphocytes, None) , ( protein: progesterone receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral blood lymphocytes, None) , ( protein: progesterone receptor, None) " }

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{ "id": "2601", "sentence": "The expression of the progesterone receptor in human peripheral blood lymphocytes was analysed, using an enzyme linked immunosorbent assay ( Abbott PgR-EIA monoclonal ), in order to evaluate its prognostic character in the context of spontaneous abortion .", "label": " ( protein: progesterone receptor, None) , ( cell type: human peripheral blood lymphocytes, None) , ( cell type: peripheral blood lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: progesterone receptor, None) , ( cell type: human peripheral blood lymphocytes, None) , ( cell type: peripheral blood lymphocytes, None) " }

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{ "id": "2602", "sentence": "Cytosols were prepared from lymphocytes of 24 healthy pregnant women (11 first, 10 second and three third trimester), seven healthy non-pregnant women , nine women with recurrent spontaneous abortion , and six healthy men .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2603", "sentence": "In addition, a human breast carcinoma cell line ( ZR-75-1 ), which expresses the progesterone receptor , was analysed throughout.", "label": " ( cell line: ZR-75-1, None) , ( protein: progesterone receptor, None) , ( cell line: human breast carcinoma cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: ZR-75-1, None) , ( protein: progesterone receptor, None) , ( cell line: human breast carcinoma cell line, None) " }

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{ "id": "2604", "sentence": "The ZR-75-1 cell line showed an expression of 642 fmol/mg whereas lymphocytes of pregnant women showed an expression < or = 4 fmol/mg.", "label": " ( cell line: ZR-75-1 cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: ZR-75-1 cell line, None) " }

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{ "id": "2605", "sentence": "Lymphocytes of non-pregnant women , women with threatened pre-term delivery, and men showed equivalent levels: 3 +/- 1, 3 +/- 2 and 5 +/- 4 fmol/mg respectively.", "label": " ( cell type: Lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: Lymphocytes, None) " }

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{ "id": "2606", "sentence": "These results show that there is no evidence of specific expression of the progesterone receptor in pregnancy and exclude any prognostic character in spontaneous abortion .", "label": " ( protein: progesterone receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: progesterone receptor, None) " }

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{ "id": "2607", "sentence": "A role for the progesterone receptor in the mechanism of the known effect of progesterone on peripheral blood lymphocytes is also excluded.", "label": " ( cell type: peripheral blood lymphocytes, None) , ( protein: progesterone receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral blood lymphocytes, None) , ( protein: progesterone receptor, None) " }

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{ "id": "2608", "sentence": "Tolerance to lipopolysaccharide involves mobilization of nuclear factor kappa B with predominance of p50 homodimers.", "label": " ( protein: nuclear factor kappa B, None) , ( protein: p50, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor kappa B, None) , ( protein: p50, None) " }

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{ "id": "2609", "sentence": "Stimulation of the human monocytic cell line Mono Mac 6 with lipopolysaccharide ( LPS ) leads to rapid and transient expression of cytokines like tumor necrosis factor ( TNF ).", "label": " ( cell line: Mono Mac 6, None) , ( protein: TNF, None) , ( cell line: human monocytic cell line, None) , ( protein: cytokines, None) , ( protein: tumor necrosis factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Mono Mac 6, None) , ( protein: TNF, None) , ( cell line: human monocytic cell line, None) , ( protein: cytokines, None) , ( protein: tumor necrosis factor, None) " }

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{ "id": "2610", "sentence": "When such cells are precultured for 2 days with a low dose of LPS (20 ng/ml) followed by stimulation with a high dose of LPS (1 microgram/ml), expression of the TNF gene is minimal, i.e. the cells are tolerant.", "label": " ( protein: TNF, None) , ( DNA: TNF gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF, None) , ( DNA: TNF gene, None) " }

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{ "id": "2611", "sentence": "In nuclear run-on analysis , such tolerant cells show only a low degree of transcription, indicating that tolerance operates at or upstream of the transcription level .", "label": " ( cell type: tolerant cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: tolerant cells, None) " }

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{ "id": "2612", "sentence": "The CD14 LPS receptor is, however, up-regulated (not down-regulated) in tolerant cells , and LPS can, in fact, still lead to activation of tolerant cells as evidenced by mobilization of the transcription factor nuclear factor kappa B ( NF-kappa B ).", "label": " ( protein: nuclear factor kappa B, None) , ( cell line: tolerant cells, None) , ( protein: CD14, None) , ( protein: transcription factor, None) , ( protein: NF-kappa B, None) , ( cell line: tolerant cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor kappa B, None) , ( cell line: tolerant cells, None) , ( protein: CD14, None) , ( protein: transcription factor, None) , ( protein: NF-kappa B, None) , ( cell line: tolerant cells, None) " }

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{ "id": "2613", "sentence": "Resolution of the NF-kappa B complex in gel shift analysis shows that the binding protein , mobilized in naive Mono Mac 6 cells , consists mainly of p50 -p65 heterodimers , while in tolerant cells , the p50 homodimer is predominant.", "label": " ( protein: p50 homodimer, None) , ( protein: -p65, None) , ( cell line: tolerant cells, None) , ( protein: p50, None) , ( protein: NF-kappa B complex, None) , ( protein: NF-kappa B, None) , ( protein: p50 -p65 heterodimers, None) , ( protein: binding protein, None) , ( cell line: naive Mono Mac 6 cells, None) , ( protein: p50, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p50 homodimer, None) , ( protein: -p65, None) , ( cell line: tolerant cells, None) , ( protein: p50, None) , ( protein: NF-kappa B complex, None) , ( protein: NF-kappa B, None) , ( protein: p50 -p65 heterodimers, None) , ( protein: binding protein, None) , ( cell line: naive Mono Mac 6 cells, None) , ( protein: p50, None) " }

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{ "id": "2614", "sentence": "This increase in p50 homodimers coincides with an increase in p105 mRNA , suggestive of a transcriptional up-regulation of p50 .", "label": " ( protein: p50, None) , ( RNA: p105 mRNA, None) , ( protein: p50, None) , ( protein: p50 homodimers, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: p50, None) , ( RNA: p105 mRNA, None) , ( protein: p50, None) , ( protein: p50 homodimers, None) " }

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{ "id": "2615", "sentence": "Reporter gene analysis reveals that the NF-kappa B complex mobilized in tolerant cells is functionally inactive in that NF-kappa B -dependent luciferase constructs containing the human immunodeficiency virus long terminal repeat or the TNF 5'-region show only minimal transactivation after LPS stimulation.", "label": " ( DNA: human immunodeficiency virus long terminal repeat, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( DNA: TNF 5#$%#-region, None) , ( protein: NF-kappa B complex, None) , ( cell line: tolerant cells, None) , ( DNA: NF-kappa B -dependent luciferase constructs, None) , ( protein: TNF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: human immunodeficiency virus long terminal repeat, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) , ( DNA: TNF 5#$%#-region, None) , ( protein: NF-kappa B complex, None) , ( cell line: tolerant cells, None) , ( DNA: NF-kappa B -dependent luciferase constructs, None) , ( protein: TNF, None) " }

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{ "id": "2616", "sentence": "Similar to Mono Mac 6 cells , primary blood monocytes , when precultured with a low dose of LPS , also become tolerant and produce little TNF after LPS stimulation .", "label": " ( cell type: primary blood monocytes, None) , ( cell line: Mono Mac 6 cells, None) , ( protein: TNF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: primary blood monocytes, None) , ( cell line: Mono Mac 6 cells, None) , ( protein: TNF, None) " }

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{ "id": "2617", "sentence": "The tolerant blood monocytes also up-regulate CD14 , and they mobilize NF-kappa B with a predominance of p50 homodimers .", "label": " ( protein: NF-kappa B, None) , ( protein: p50, None) , ( protein: CD14, None) , ( cell type: tolerant blood monocytes, None) , ( protein: p50 homodimers, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: p50, None) , ( protein: CD14, None) , ( cell type: tolerant blood monocytes, None) , ( protein: p50 homodimers, None) " }

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{ "id": "2618", "sentence": "Taken together, these results demonstrate that tolerance to LPS is determined by post-receptor mechanisms that involve an altered composition of the NF-kappa B complex .", "label": " ( protein: NF-kappa B complex, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B complex, None) , ( protein: NF-kappa B, None) " }

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{ "id": "2619", "sentence": "Analysis of Oct2-isoform expression in lipopolysaccharide -stimulated B lymphocytes .", "label": " ( cell line: lipopolysaccharide -stimulated B lymphocytes, None) , ( protein: Oct2-isoform, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: lipopolysaccharide -stimulated B lymphocytes, None) , ( protein: Oct2-isoform, None) " }

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{ "id": "2620", "sentence": "Oct2-isoform expression in splenic B cells stimulated with lipopolysaccharide or lipopolysaccharide plus phorbol-di-butyrate was analysed by cDNA cloning .", "label": " ( cell type: splenic B cells, None) , ( protein: Oct2-isoform, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: splenic B cells, None) , ( protein: Oct2-isoform, None) " }

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{ "id": "2621", "sentence": "The frequency of Oct2-positive clones was 1/15,000 in both libraries.", "label": " ( cell line: Oct2-positive clones, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Oct2-positive clones, None) " }

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{ "id": "2622", "sentence": "Two new isoforms were found that generate novel amino- or carboxy- terminal sequences .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2623", "sentence": "An isoform lacking exon 11 destroyed the carboxy-terminal leucin-zipper region and introduced a frame shift creating a novel, proline -rich carboxy terminus .", "label": " ( DNA: exon 11, None) , ( protein: proline -rich carboxy terminus, None) , ( protein: carboxy-terminal leucin-zipper region, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: exon 11, None) , ( protein: proline -rich carboxy terminus, None) , ( protein: carboxy-terminal leucin-zipper region, None) " }

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{ "id": "2624", "sentence": "A new exon containing a highly basic region (4c) was characterized, between exons 4 and 5 .", "label": " ( DNA: exon, None) , ( DNA: between exons 4 and 5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: exon, None) , ( DNA: between exons 4 and 5, None) " }

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{ "id": "2625", "sentence": "This exon was inserted between glutamine-rich regions 2 and 3 , carboxy terminal of a tentative leucine-zipper structure .", "label": " ( DNA: glutamine-rich regions 2 and 3, None) , ( protein: carboxy terminal, None) , ( DNA: between glutamine-rich regions 2 and 3, None) , ( protein: leucine-zipper structure, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: glutamine-rich regions 2 and 3, None) , ( protein: carboxy terminal, None) , ( DNA: between glutamine-rich regions 2 and 3, None) , ( protein: leucine-zipper structure, None) " }

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{ "id": "2626", "sentence": "In addition, a new combination isoform containing Oct2a 's amino terminal insert ( exon 7a ) and Oct2b 's carboxy terminal insert ( exon 13 ) was found that created a novel large isoform, Oct2ab .", "label": " ( DNA: exon 7a, None) , ( protein: Oct2b #$%#s carboxy terminal insert, None) , ( protein: Oct2b, None) , ( protein: Oct2a, None) , ( protein: Oct2ab, None) , ( protein: Oct2a #$%#s amino terminal insert, None) , ( DNA: exon 13, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: exon 7a, None) , ( protein: Oct2b #$%#s carboxy terminal insert, None) , ( protein: Oct2b, None) , ( protein: Oct2a, None) , ( protein: Oct2ab, None) , ( protein: Oct2a #$%#s amino terminal insert, None) , ( DNA: exon 13, None) " }

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{ "id": "2627", "sentence": "More frequent use of the classical Oct2a and Oct2b isoforms was observed in the lipopolysaccharide -stimulated B cells , while a preference for the Oct2ab and Oct2ba isoforms was observed in lipopolysaccharide plus phorbol-di-butyrate -treated cells .", "label": " ( protein: Oct2ab, None) , ( protein: Oct2ba, None) , ( cell line: lipopolysaccharide plus phorbol-di-butyrate -treated cells, None) , ( protein: Oct2a, None) , ( cell line: lipopolysaccharide -stimulated B cells, None) , ( protein: Oct2b, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Oct2ab, None) , ( protein: Oct2ba, None) , ( cell line: lipopolysaccharide plus phorbol-di-butyrate -treated cells, None) , ( protein: Oct2a, None) , ( cell line: lipopolysaccharide -stimulated B cells, None) , ( protein: Oct2b, None) " }

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{ "id": "2628", "sentence": "Positive regulators of the lineage-specific transcription factor GATA-1 in differentiating erythroid cells .", "label": " ( protein: transcription factor, None) , ( protein: GATA-1, None) , ( cell type: differentiating erythroid cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor, None) , ( protein: GATA-1, None) , ( cell type: differentiating erythroid cells, None) " }

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{ "id": "2629", "sentence": "The zinc finger transcription factor GATA-1 is a major regulator of gene expression in erythroid , megakaryocyte , and mast cell lineages .", "label": " ( protein: zinc finger transcription factor, None) , ( protein: GATA-1, None) , ( protein: transcription factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: zinc finger transcription factor, None) , ( protein: GATA-1, None) , ( protein: transcription factor, None) " }

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{ "id": "2630", "sentence": "GATA-1 binds to WGATAR consensus motifs in the regulatory regions of virtually all erythroid cell-specific genes .", "label": " ( DNA: erythroid cell-specific genes, None) , ( DNA: WGATAR consensus motifs, None) , ( DNA: regulatory regions, None) , ( protein: GATA-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: erythroid cell-specific genes, None) , ( DNA: WGATAR consensus motifs, None) , ( DNA: regulatory regions, None) , ( protein: GATA-1, None) " }

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{ "id": "2631", "sentence": "Analyses with cultured cells and cell-free systems have provided strong evidence that GATA-1 is involved in control of globin gene expression during erythroid differentiation .", "label": " ( protein: GATA-1, None) , ( cell line: cultured cells, None) , ( DNA: globin gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA-1, None) , ( cell line: cultured cells, None) , ( DNA: globin gene, None) " }

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{ "id": "2632", "sentence": "Targeted mutagenesis of the GATA-1 gene in embryonic stem cells has demonstrated its requirement in normal erythroid development .", "label": " ( DNA: GATA-1 gene, None) , ( cell type: embryonic stem cells, None) , ( protein: GATA-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: GATA-1 gene, None) , ( cell type: embryonic stem cells, None) , ( protein: GATA-1, None) " }

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{ "id": "2633", "sentence": "Efficient rescue of the defect requires an intact GATA element in the distal promoter , suggesting autoregulatory control of GATA-1 transcription .", "label": " ( protein: GATA-1, None) , ( DNA: GATA element, None) , ( DNA: distal promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA-1, None) , ( DNA: GATA element, None) , ( DNA: distal promoter, None) " }

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{ "id": "2634", "sentence": "To examine whether GATA-1 expression involves additional regulatory factors or is maintained entirely by an autoregulatory loop , we have used a transient heterokaryon system to test the ability of erythroid factors to activate the GATA-1 gene in nonerythroid nuclei .", "label": " ( protein: GATA-1, None) , ( protein: GATA-1, None) , ( protein: regulatory factors, None) , ( DNA: GATA-1 gene, None) , ( protein: erythroid factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA-1, None) , ( protein: GATA-1, None) , ( protein: regulatory factors, None) , ( DNA: GATA-1 gene, None) , ( protein: erythroid factors, None) " }

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{ "id": "2635", "sentence": "We show here that proerythroblasts and mature erythroid cells contain a diffusible activity ( TAG ) capable of transcriptional activation of GATA-1 and that this activity decreases during the terminal differentiation of erythroid cells .", "label": " ( protein: GATA-1, None) , ( cell type: proerythroblasts, None) , ( cell type: mature erythroid cells, None) , ( cell type: erythroid cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA-1, None) , ( cell type: proerythroblasts, None) , ( cell type: mature erythroid cells, None) , ( cell type: erythroid cells, None) " }

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{ "id": "2636", "sentence": "Nuclei from GATA-1 -mutant embryonic stem cells can still be reprogrammed to express their globin genes in erythroid heterokaryons , indicating that de novo induction of GATA-1 is not required for globin gene activation following cell fusion .", "label": " ( cell line: GATA-1 -mutant embryonic stem cells, None) , ( cell type: erythroid heterokaryons, None) , ( cell type: embryonic stem cells, None) , ( DNA: globin genes, None) , ( protein: GATA-1, None) , ( protein: GATA-1, None) , ( DNA: globin gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: GATA-1 -mutant embryonic stem cells, None) , ( cell type: erythroid heterokaryons, None) , ( cell type: embryonic stem cells, None) , ( DNA: globin genes, None) , ( protein: GATA-1, None) , ( protein: GATA-1, None) , ( DNA: globin gene, None) " }

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{ "id": "2637", "sentence": "Role of HIV-1 Nef expression in activation pathways in CD4 + T cells.", "label": " ( protein: HIV-1 Nef, None) , ( protein: CD4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: HIV-1 Nef, None) , ( protein: CD4, None) " }

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{ "id": "2638", "sentence": "The role of the human immunodeficiency virus ( HIV-1 ) Nef protein in T cell activation pathways was investigated using a Jurkat CD4 + cell line stably transfected with a Nef expression vector .", "label": " ( cell line: Jurkat CD4 + cell line, None) , ( protein: human immunodeficiency virus ( HIV-1 ) Nef protein, None) , ( protein: Nef protein, None) , ( protein: CD4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Jurkat CD4 + cell line, None) , ( protein: human immunodeficiency virus ( HIV-1 ) Nef protein, None) , ( protein: Nef protein, None) , ( protein: CD4, None) " }

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{ "id": "2639", "sentence": "Secretion of IL-2 and TNF-alpha , surface expression of IL-2R , and DNA-binding activity of NF-kappa B and AP-1 (Fos/Jun) complex in response to phorbol myristate acetate , TNF-alpha , or immobilized antibodies to CD3 were monitored.", "label": " ( protein: TNF-alpha, None) , ( protein: AP-1 (Fos/Jun) complex, None) , ( protein: TNF-alpha, None) , ( protein: IL-2, None) , ( protein: IL-2R, None) , ( protein: NF-kappa B, None) , ( protein: CD3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF-alpha, None) , ( protein: AP-1 (Fos/Jun) complex, None) , ( protein: TNF-alpha, None) , ( protein: IL-2, None) , ( protein: IL-2R, None) , ( protein: NF-kappa B, None) , ( protein: CD3, None) " }

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{ "id": "2640", "sentence": "These parameters were not modified by Nef expression in Jurkat cells , whereas stimulation with the same stimuli resulted in partial inhibition of LTR activation in Nef + Jurkat cells .", "label": " ( DNA: LTR, None) , ( cell line: Nef + Jurkat cells, None) , ( protein: Nef, None) , ( cell line: Jurkat cells, None) , ( cell line: Jurkat cells, None) , ( protein: Nef, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LTR, None) , ( cell line: Nef + Jurkat cells, None) , ( protein: Nef, None) , ( cell line: Jurkat cells, None) , ( cell line: Jurkat cells, None) , ( protein: Nef, None) " }

[]

{ "id": "2641", "sentence": "This inhibition was not mediated through Nef phosphorylation on Thr-15 or GTP -binding activity because mutations in critical sites did not alter this inhibition.", "label": " ( protein: Nef, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Nef, None) " }

[]

{ "id": "2642", "sentence": "Analysis of truncated LTRs confirmed that inhibition of LTR activation was not mediated through NF-kappa B -binding activity but through the region containing the negative responding elements ( NREs ).", "label": " ( DNA: LTR, None) , ( protein: NF-kappa B, None) , ( DNA: LTRs, None) , ( DNA: negative responding elements, None) , ( DNA: NREs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: LTR, None) , ( protein: NF-kappa B, None) , ( DNA: LTRs, None) , ( DNA: negative responding elements, None) , ( DNA: NREs, None) " }

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{ "id": "2643", "sentence": "These results suggest that Nef downmodulates LTR activation without significantly inhibiting the capacity of T cells to respond to immunological activations .", "label": " ( cell type: T cells, None) , ( protein: Nef, None) , ( DNA: LTR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: Nef, None) , ( DNA: LTR, None) " }

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{ "id": "2644", "sentence": "Tat-binding protein 7 is a subunit of the 26S protease .", "label": " ( protein: 26S protease, None) , ( protein: Tat-binding protein 7, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: 26S protease, None) , ( protein: Tat-binding protein 7, None) " }

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{ "id": "2645", "sentence": "Subunit 6 ( S6 ), an integral component of the 26S protease from human erythrocytes , has been studied by SDS-PAGE , peptide mapping and sequence analysis .", "label": " ( cell type: human erythrocytes, None) , ( protein: 26S protease, None) , ( protein: S6, None) , ( protein: Subunit 6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human erythrocytes, None) , ( protein: 26S protease, None) , ( protein: S6, None) , ( protein: Subunit 6, None) " }

[]

{ "id": "2646", "sentence": "S6 was cleaved with CNBr and three internal peptides were sequenced.", "label": " ( protein: CNBr, None) , ( protein: S6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CNBr, None) , ( protein: S6, None) " }

[]

{ "id": "2647", "sentence": "A comparison with known proteins in Genbank revealed that all three S6 peptides match the predicted sequence of TBP7 , Tat-binding protein 7 .", "label": " ( protein: Tat-binding protein 7, None) , ( protein: TBP7, None) , ( protein: S6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Tat-binding protein 7, None) , ( protein: TBP7, None) , ( protein: S6, None) " }

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{ "id": "2648", "sentence": "Based on peptide matches covering more than 10% of the TBP7 sequence , and the fact that the migration of S6 on SDS-PAGE is consistent with the estimated molecular mass for TBP7 , we conclude that subunit 6 of the 26S protease is TBP7 .", "label": " ( protein: TBP7, None) , ( protein: S6, None) , ( protein: TBP7, None) , ( protein: TBP7 sequence, None) , ( protein: subunit 6, None) , ( protein: TBP7, None) , ( protein: 26S protease, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TBP7, None) , ( protein: S6, None) , ( protein: TBP7, None) , ( protein: TBP7 sequence, None) , ( protein: subunit 6, None) , ( protein: TBP7, None) , ( protein: 26S protease, None) " }

[]

{ "id": "2649", "sentence": "Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues .", "label": " ( protein: I kappa B alpha, None) , ( protein: nuclear factor kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I kappa B alpha, None) , ( protein: nuclear factor kappa B, None) " }

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{ "id": "2650", "sentence": "The response of mammalian cells to stress is controlled by transcriptional regulatory proteins such as nuclear factor kappa B ( NF-kappa B ) to induce a wide variety of early response genes .", "label": " ( protein: nuclear factor kappa B, None) , ( protein: NF-kappa B, None) , ( cell type: mammalian cells, None) , ( DNA: early response genes, None) , ( protein: transcriptional regulatory proteins, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor kappa B, None) , ( protein: NF-kappa B, None) , ( cell type: mammalian cells, None) , ( DNA: early response genes, None) , ( protein: transcriptional regulatory proteins, None) " }

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{ "id": "2651", "sentence": "In this report, we show that exposure of cells to hypoxia (0.02% O2) results in I kappa B alpha degradation, increased NF-kappa B DNA binding activity , and transactivation of a reporter gene construct containing two NF-kappa B DNA binding sites .", "label": " ( protein: I kappa B alpha, None) , ( DNA: reporter gene construct, None) , ( DNA: NF-kappa B DNA binding sites, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I kappa B alpha, None) , ( DNA: reporter gene construct, None) , ( DNA: NF-kappa B DNA binding sites, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "2652", "sentence": "Pretreatment of cells with protein tyrosine kinase inhibitors and the dominant negative allele of c-Raf-1 ( Raf 301 ) inhibited I kappa B alpha degradation , NF-kappa B binding , and transactivation of kappa B reporter constructs by hypoxia .", "label": " ( protein: NF-kappa B, None) , ( DNA: dominant negative allele, None) , ( protein: tyrosine kinase, None) , ( protein: I kappa B alpha, None) , ( DNA: kappa B reporter constructs, None) , ( protein: Raf 301, None) , ( DNA: c-Raf-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( DNA: dominant negative allele, None) , ( protein: tyrosine kinase, None) , ( protein: I kappa B alpha, None) , ( DNA: kappa B reporter constructs, None) , ( protein: Raf 301, None) , ( DNA: c-Raf-1, None) " }

[]

{ "id": "2653", "sentence": "To demonstrate a direct link between changes in the phosphorylation pattern of I kappa B alpha with NF-kappa B activation , we immunoprecipitated I kappa B alpha after varying times of hypoxic exposure and found that its tyrosine phosphorylation status increased during hypoxic exposure .", "label": " ( protein: NF-kappa B, None) , ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha, None) " }

[]

{ "id": "2654", "sentence": "Inhibition of the transfer of tyrosine phosphoryl groups onto I kappa B alpha prevented I kappa B alpha degradation and NF-kappa B binding .", "label": " ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I kappa B alpha, None) , ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "2655", "sentence": "In comparison to other activators of NF-kappa B such as phorbol myristate acetate or tumor necrosis factor , we did not detect changes in the tyrosine phosphorylation status of I kappa B alpha following treatment with either of these agents.", "label": " ( protein: tumor necrosis factor, None) , ( protein: NF-kappa B, None) , ( protein: I kappa B alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: tumor necrosis factor, None) , ( protein: NF-kappa B, None) , ( protein: I kappa B alpha, None) " }

[]

{ "id": "2656", "sentence": "These results suggest that tyrosine phosphorylation of I kappa B alpha during hypoxia is an important proximal step which precedes its dissociation and degradation from NF-kappa B .", "label": " ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: I kappa B alpha, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "2657", "sentence": "Overproduction of NFKB2 ( lyt-10 ) and c-Rel : a mechanism for HTLV-I Tax -mediated trans-activation via the NF-kappa B signalling pathway .", "label": " ( protein: c-Rel, None) , ( protein: HTLV-I Tax, None) , ( protein: lyt-10, None) , ( protein: NFKB2, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c-Rel, None) , ( protein: HTLV-I Tax, None) , ( protein: lyt-10, None) , ( protein: NFKB2, None) , ( protein: NF-kappa B, None) " }

[]

{ "id": "2658", "sentence": "Molecular, biochemical and epidemiological evidence implicate HTLV-I as an etiologic agent of adult T cell leukemia ( ATL ).", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2659", "sentence": "The Tax protein of HTLV-I , a positive transcriptional activator of HTLV-I gene expression , is a viral oncogene that also increases transcription of cellular genes including GM-CSF , IL-2R alpha and IL-2 .", "label": " ( protein: positive transcriptional activator, None) , ( DNA: cellular genes, None) , ( protein: GM-CSF, None) , ( protein: Tax protein, None) , ( protein: IL-2, None) , ( protein: IL-2R alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: positive transcriptional activator, None) , ( DNA: cellular genes, None) , ( protein: GM-CSF, None) , ( protein: Tax protein, None) , ( protein: IL-2, None) , ( protein: IL-2R alpha, None) " }

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{ "id": "2660", "sentence": "One of the cellular targets of the trans-activating effects of Tax is the NF-kappa B /Rel family of transcription factors , pleiotropic regulators of immunoregulatory , cytokine and viral gene expression .", "label": " ( protein: transcription factors, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B /Rel family, None) , ( protein: pleiotropic regulators, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factors, None) , ( protein: NF-kappa B, None) , ( protein: NF-kappa B /Rel family, None) , ( protein: pleiotropic regulators, None) " }

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{ "id": "2661", "sentence": "In this report, we demonstrate that NFKB2 ( lyt-10 ) and c-Rel are overexpressed in HTLV-I infected and Tax-expressing cells and, together, account for the majority of the constitutive NF-kappa B binding activity in these cells before and after PMA stimulation .", "label": " ( protein: lyt-10, None) , ( protein: NFKB2, None) , ( protein: NF-kappa B, None) , ( cell type: Tax-expressing cells, None) , ( protein: c-Rel, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: lyt-10, None) , ( protein: NFKB2, None) , ( protein: NF-kappa B, None) , ( cell type: Tax-expressing cells, None) , ( protein: c-Rel, None) " }

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{ "id": "2662", "sentence": "Most importantly, we show a Tax -dependent correlation between expression of NFKB2 ( p100 ) and processing to the DNA binding NFKB2 ( p52 ) form, induction of c-Rel , and trans-activation of NF-kappa B -mediated gene expression .", "label": " ( protein: c-Rel, None) , ( protein: NFKB2, None) , ( protein: p52, None) , ( protein: NF-kappa B, None) , ( protein: p100, None) , ( protein: Tax, None) , ( protein: NFKB2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c-Rel, None) , ( protein: NFKB2, None) , ( protein: p52, None) , ( protein: NF-kappa B, None) , ( protein: p100, None) , ( protein: Tax, None) , ( protein: NFKB2, None) " }

[]

{ "id": "2663", "sentence": "Furthermore, the NFKB2 precursor is physically associated with c-Rel and with Tax in HTLV-I infected cells .", "label": " ( cell type: HTLV-I infected cells, None) , ( protein: c-Rel, None) , ( protein: NFKB2, None) , ( protein: Tax, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: HTLV-I infected cells, None) , ( protein: c-Rel, None) , ( protein: NFKB2, None) , ( protein: Tax, None) " }

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{ "id": "2664", "sentence": "We propose that NFKB2 synthesis and processing allows continuous nuclear expression of an otherwise cytoplasmic protein and, in conjunction with overexpression of c-Rel , NFKB2 alters the NF-kappa B signalling pathway and contributes to leukemic transformation of T cells by HTLV-I .", "label": " ( protein: cytoplasmic protein, None) , ( cell type: T cells, None) , ( protein: NFKB2, None) , ( protein: NF-kappa B, None) , ( protein: c-Rel, None) , ( protein: NFKB2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytoplasmic protein, None) , ( cell type: T cells, None) , ( protein: NFKB2, None) , ( protein: NF-kappa B, None) , ( protein: c-Rel, None) , ( protein: NFKB2, None) " }

[]

{ "id": "2665", "sentence": "Retinoic acid downmodulates erythroid differentiation and GATA1 expression in purified adult-progenitor culture .", "label": " ( protein: GATA1, None) , ( cell line: purified adult-progenitor culture, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA1, None) , ( cell line: purified adult-progenitor culture, None) " }

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{ "id": "2666", "sentence": "All-trans retinoic acid ( RA ) is an important morphogen in vertebrate development, a normal constituent in human adult blood and is also involved in the control of cell growth and differentiation in acute promyelocytic leukemia .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2667", "sentence": "We have examined the effects of RA on normal hematopoiesis by using early hematopoietic progenitor cells ( HPC ) stringently purified from adult peripheral blood .", "label": " ( cell type: HPC, None) , ( cell type: hematopoietic progenitor cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: HPC, None) , ( cell type: hematopoietic progenitor cells, None) " }

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{ "id": "2668", "sentence": "In clonogenetic fetal calf serum -supplemented (FCS+) or -nonsupplemented (FCS-) culture treated with saturating levels of interleukin-3 ( IL-3 ) granulocyte-macrophage colony-stimulating factor ( GM-CSF ) and erythropoietin ( Ep ) (combined with c-kit ligand in FCS(-)-culture conditions ), RA induces a dramatic dose-dependent shift from erythroid to granulomonocytic colony formation , the latter colonies being essentially represented by granulocytic clones .", "label": " ( protein: interleukin-3, None) , ( protein: c-kit, None) , ( protein: erythropoietin, None) , ( protein: GM-CSF, None) , ( protein: Ep, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( protein: IL-3, None) , ( cell line: granulocytic clones, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin-3, None) , ( protein: c-kit, None) , ( protein: erythropoietin, None) , ( protein: GM-CSF, None) , ( protein: Ep, None) , ( protein: granulocyte-macrophage colony-stimulating factor, None) , ( protein: IL-3, None) , ( cell line: granulocytic clones, None) " }

[]

{ "id": "2669", "sentence": "This shift is apparently not caused by a recruitment phenomenon, because in FCS+ culture , the total number of colonies is not significantly modified by RA addition.", "label": " ( cell line: FCS+ culture, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: FCS+ culture, None) " }

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{ "id": "2670", "sentence": "In FCS- liquid-suspension culture supplemented with saturating Ep level and low-dose IL-3 /GM-CSF , adult HPC undergo unilineage erythropoietic differentiation : Here again, treatment with high-dose RA induces a shift from the erythroid to granulocytic differentiation pathway .", "label": " ( cell type: HPC, None) , ( protein: Ep, None) , ( protein: low-dose IL-3 /GM-CSF, None) , ( protein: /GM-CSF, None) , ( protein: IL-3, None) , ( cell line: FCS- liquid-suspension culture, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: HPC, None) , ( protein: Ep, None) , ( protein: low-dose IL-3 /GM-CSF, None) , ( protein: /GM-CSF, None) , ( protein: IL-3, None) , ( cell line: FCS- liquid-suspension culture, None) " }

[]

{ "id": "2671", "sentence": "Studies on RA time-response or pulse treatment in semisolid or liquid culture show that early RA addition is most effective, thus indicating that early but not late HPC are sensitive to its action.", "label": " ( cell type: HPC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: HPC, None) " }

[]

{ "id": "2672", "sentence": "We then analyzed the expression of the master GATA1 gene , which encodes a finger transcription factor required for normal erythroid development; addition of RA to HPC stimulated into unilineage erythropoietic differentiation in liquid culture caused a virtually complete inhibition of GATA1 mRNA induction .", "label": " ( protein: GATA1, None) , ( cell type: HPC, None) , ( DNA: master GATA1 gene, None) , ( protein: finger transcription factor, None) , ( RNA: GATA1 mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA1, None) , ( cell type: HPC, None) , ( DNA: master GATA1 gene, None) , ( protein: finger transcription factor, None) , ( RNA: GATA1 mRNA, None) " }

[]

{ "id": "2673", "sentence": "These results indicate that RA directly inhibits the erythroid differentiation program at the level of early adult HPC , and may lead to a shift from the erythroid to granulocytic differentiation pathway .", "label": " ( cell type: HPC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: HPC, None) " }

[]

{ "id": "2674", "sentence": "This phenomenon is correlated with inhibition of GATA1 induction in the early stages of erythropoietic differentiation .", "label": " ( protein: GATA1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: GATA1, None) " }

[]

{ "id": "2675", "sentence": "Induction of phosphatidylinositol turnover and EGR-1 mRNA expression by crosslinking of surface IgM and IgD in the human B cell line B104 .", "label": " ( protein: IgM, None) , ( RNA: EGR-1 mRNA, None) , ( protein: IgD, None) , ( cell line: human B cell line B104, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IgM, None) , ( RNA: EGR-1 mRNA, None) , ( protein: IgD, None) , ( cell line: human B cell line B104, None) " }

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{ "id": "2676", "sentence": "We have previously shown that a human B lymphoma cell line, B104 , expressed surface IgM ( sIgM ) and surface IgD ( sIgD ), and that crosslinking of sIgM and sIgD by anti- IgM antibody (Ab) and anti- IgD Ab , respectively, induced Ca2+ influx to almost the same degree, whereas only sIgM -crosslinking caused B104 cell death .", "label": " ( protein: sIgM, None) , ( protein: sIgM, None) , ( protein: IgM, None) , ( cell line: human B lymphoma cell line, B104, None) , ( protein: IgD, None) , ( protein: IgM, None) , ( protein: surface IgM, None) , ( protein: IgD, None) , ( protein: surface IgD, None) , ( protein: sIgD, None) , ( protein: anti- IgM antibody (Ab), None) , ( protein: anti- IgD Ab, None) , ( protein: sIgM, None) , ( protein: sIgD, None) , ( cell line: B104 cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: sIgM, None) , ( protein: sIgM, None) , ( protein: IgM, None) , ( cell line: human B lymphoma cell line, B104, None) , ( protein: IgD, None) , ( protein: IgM, None) , ( protein: surface IgM, None) , ( protein: IgD, None) , ( protein: surface IgD, None) , ( protein: sIgD, None) , ( protein: anti- IgM antibody (Ab), None) , ( protein: anti- IgD Ab, None) , ( protein: sIgM, None) , ( protein: sIgD, None) , ( cell line: B104 cell, None) " }

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{ "id": "2677", "sentence": "Here, we investigated the accumulation of cyclic AMP ( cAMP ), the hydrolysis of inositol phosphates , protein kinase C ( PKC ) activity and the induction of Egr-1 and c-fos mRNA expression by sIgM- and sIgD- crosslinking to examine differences in the signals mediated through sIgM and sIgD in B104 cells .", "label": " ( protein: protein kinase C, None) , ( cell line: B104 cells, None) , ( protein: PKC, None) , ( protein: sIgM, None) , ( protein: sIgD, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: protein kinase C, None) , ( cell line: B104 cells, None) , ( protein: PKC, None) , ( protein: sIgM, None) , ( protein: sIgD, None) " }

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{ "id": "2678", "sentence": "Both sIgM- and sIgD- crosslinking with antibodies induced elevation of cAMP levels , phosphatidylinositol turnover , PKC activation and expression of Egr-1 and c-fos mRNA , although sIgM -crosslinking was more effective than sIgD -crosslinking , presumably due to the higher expression of sIgM than of sIgD .", "label": " ( protein: sIgM, None) , ( protein: PKC, None) , ( protein: sIgM, None) , ( protein: sIgD, None) , ( protein: sIgD, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: sIgM, None) , ( protein: PKC, None) , ( protein: sIgM, None) , ( protein: sIgD, None) , ( protein: sIgD, None) " }

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{ "id": "2679", "sentence": "Egr-1 mRNA expression induced by sIgM- and sIgD- crosslinking was inhibited by H7 , erbstatin and genistein , but not by HA1004 .", "label": " ( DNA: Egr-1, None) , ( protein: H7, None) , ( RNA: Egr-1 mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Egr-1, None) , ( protein: H7, None) , ( RNA: Egr-1 mRNA, None) " }

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{ "id": "2680", "sentence": "Erbstatin and genistein inhibited the sIg-crosslinking-induced Egr-1 mRNA expression in a dose-dependent manner parallel to that observed in the inhibition of sIg-crosslinking-induced protein tyrosine phosphorylation.", "label": " ( DNA: Egr-1, None) , ( RNA: Egr-1 mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Egr-1, None) , ( RNA: Egr-1 mRNA, None) " }

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{ "id": "2681", "sentence": "Phorbol myristate acetate induced Egr-1 mRNA expression but forskolin and dibutyryl cyclic AMP did not.", "label": " ( RNA: Egr-1 mRNA, None) , ( DNA: Egr-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: Egr-1 mRNA, None) , ( DNA: Egr-1, None) " }

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{ "id": "2682", "sentence": "These findings suggest that the Egr-1 mRNA activating signals through sIgM and sIgD are protein tyrosine kinase- and PKC- dependent , but protein kinase A -independent .", "label": " ( DNA: Egr-1, None) , ( RNA: Egr-1 mRNA, None) , ( protein: protein kinase A, None) , ( protein: sIgD, None) , ( protein: sIgM, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: Egr-1, None) , ( RNA: Egr-1 mRNA, None) , ( protein: protein kinase A, None) , ( protein: sIgD, None) , ( protein: sIgM, None) " }

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{ "id": "2683", "sentence": "Cyclosporin A ( CsA ) and FK506 rescued B104 cells from death induced by anti-IgM Ab , but did not affect the expression of Egr-1 and c-fos mRNA , showing that CsA and FK506 affect signal transducers differently from or downstream to these molecules.", "label": " ( protein: anti-IgM Ab, None) , ( protein: Egr-1, None) , ( cell line: B104 cells, None) , ( RNA: c-fos mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti-IgM Ab, None) , ( protein: Egr-1, None) , ( cell line: B104 cells, None) , ( RNA: c-fos mRNA, None) " }

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{ "id": "2684", "sentence": "The difference in signals transduced through sIgM and sIgD in B104 cells is discussed.", "label": " ( protein: sIgD, None) , ( cell line: B104 cells, None) , ( protein: sIgM, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: sIgD, None) , ( cell line: B104 cells, None) , ( protein: sIgM, None) " }

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{ "id": "2685", "sentence": "Direct exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin ( TCDD ) increases infectivity of human erythrocytes to a malarial parasite .", "label": " ( cell type: human erythrocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human erythrocytes, None) " }

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{ "id": "2686", "sentence": "Direct exposure to 10 nM 2,3,7,8-TCDD caused a 75% increase and a 2-fold increase in the infectivity of isolated human erythrocytes to P. falciparum after 48 hours when the parasites were in an unsynchronized or synchronized state of growth, respectively.", "label": " ( cell type: human erythrocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human erythrocytes, None) " }

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{ "id": "2687", "sentence": "Treatment of human erythrocytes with 10 microM sodium orthovanadate ( NaOV ), an inhibitor of plasma membrane Ca-ATPase and phosphotyrosine phosphatase , decreased parasitemia by 30%.", "label": " ( protein: plasma membrane Ca-ATPase, None) , ( protein: phosphotyrosine phosphatase, None) , ( cell type: human erythrocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: plasma membrane Ca-ATPase, None) , ( protein: phosphotyrosine phosphatase, None) , ( cell type: human erythrocytes, None) " }

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{ "id": "2688", "sentence": "Co-treatment of RBCs with TCDD and NaOV completely blocked the TCDD -induced increase in parasitemia .", "label": " ( cell type: RBCs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: RBCs, None) " }

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{ "id": "2689", "sentence": "Because erythrocytes are anucleated, these results are discussed as evidence for biochemical changes by TCDD without requiring the activation of gene products .", "label": " ( protein: gene products, None) , ( cell type: erythrocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: gene products, None) , ( cell type: erythrocytes, None) " }

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{ "id": "2690", "sentence": "Evidence for a trans-acting activator function regulating the expression of the human CD5 antigen .", "label": " ( protein: CD5, None) , ( protein: human CD5 antigen, None) , ( protein: trans-acting activator, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD5, None) , ( protein: human CD5 antigen, None) , ( protein: trans-acting activator, None) " }

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{ "id": "2691", "sentence": "Interspecies somatic cell hybrids were generated by fusing the mouse T-lymphoma cell line , BW5147 , with normal human T lymphocytes at different stages of differentiation .", "label": " ( cell line: mouse T-lymphoma cell line, None) , ( cell line: somatic cell hybrids, None) , ( cell type: normal human T lymphocytes, None) , ( cell line: BW5147, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: mouse T-lymphoma cell line, None) , ( cell line: somatic cell hybrids, None) , ( cell type: normal human T lymphocytes, None) , ( cell line: BW5147, None) " }

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{ "id": "2692", "sentence": "Thymocytes , activated peripheral T lymphocytes , or an activated T-cell clone were used as human partners , respectively, in three independent fusions.", "label": " ( cell line: activated T-cell clone, None) , ( cell type: activated peripheral T lymphocytes, None) , ( cell type: Thymocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: activated T-cell clone, None) , ( cell type: activated peripheral T lymphocytes, None) , ( cell type: Thymocytes, None) " }

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{ "id": "2693", "sentence": "Irrespective of the human cell partner used for fusion, a certain number of hybrids lost CD5 surface expression over a period of time in culture.", "label": " ( protein: CD5, None) , ( cell line: hybrids, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD5, None) , ( cell line: hybrids, None) " }

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{ "id": "2694", "sentence": "Analysis at the phenotype and genetic level showed that lack of CD5 expression was due neither to segregation of human autosome 11 , on which the CD5 gene has been mapped, nor to deletion of the CD5 structural gene .", "label": " ( DNA: CD5 gene, None) , ( DNA: CD5 structural gene, None) , ( protein: CD5, None) , ( protein: CD5, None) , ( DNA: human autosome 11, None) , ( protein: CD5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: CD5 gene, None) , ( DNA: CD5 structural gene, None) , ( protein: CD5, None) , ( protein: CD5, None) , ( DNA: human autosome 11, None) , ( protein: CD5, None) " }

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{ "id": "2695", "sentence": "Furthermore, loss of CD5 surface expression correlated with the absence of specific mRNA .", "label": " ( RNA: mRNA, None) , ( protein: CD5, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: mRNA, None) , ( protein: CD5, None) " }

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{ "id": "2696", "sentence": "Since these hybrids preferentially segregate human chromosomes, these results indicate the existence of a non-syntenic trans-active locus , or loci, positively controlling the expression of the human CD5 gene .", "label": " ( DNA: non-syntenic trans-active locus, None) , ( protein: CD5, None) , ( DNA: human CD5 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: non-syntenic trans-active locus, None) , ( protein: CD5, None) , ( DNA: human CD5 gene, None) " }

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{ "id": "2697", "sentence": "Induction of the CD11b gene during activation of the monocytic cell line U937 requires a novel nuclear factor MS-2 [published erratum appears in J Immunol 1999 Jul 15;163(2):1091]", "label": " ( protein: nuclear factor, None) , ( DNA: CD11b gene, None) , ( protein: MS-2, None) , ( cell line: monocytic cell line U937, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nuclear factor, None) , ( DNA: CD11b gene, None) , ( protein: MS-2, None) , ( cell line: monocytic cell line U937, None) " }

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{ "id": "2698", "sentence": "The differentiation of myeloid precursors into mature myelomonocytic cells is characterized by the induction of the gene encoding the beta2 integrin CD11b .", "label": " ( cell type: myeloid precursors, None) , ( protein: beta2 integrin, None) , ( cell type: myelomonocytic cells, None) , ( protein: CD11b, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: myeloid precursors, None) , ( protein: beta2 integrin, None) , ( cell type: myelomonocytic cells, None) , ( protein: CD11b, None) " }

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{ "id": "2699", "sentence": "The transcription factors Sp1 and PU.1 prime the CD11b promoter , but the nature of the factors responsible for its inducible expression are unknown.", "label": " ( protein: CD11b, None) , ( protein: transcription factors, None) , ( protein: PU.1 prime, None) , ( DNA: CD11b promoter, None) , ( protein: Sp1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD11b, None) , ( protein: transcription factors, None) , ( protein: PU.1 prime, None) , ( DNA: CD11b promoter, None) , ( protein: Sp1, None) " }