Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "2400", "sentence": "Arrested development : understanding v-abl .", "label": " ( DNA: v-abl, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: v-abl, None) " }

[]

{ "id": "2401", "sentence": "The protein tyrosine kinase activity of the v-abl oncogene has been demonstrated to subvert the normal second messenger systems used by lymphoid cells for growth and differentiation .", "label": " ( DNA: v-abl, None) , ( DNA: v-abl oncogene, None) , ( cell type: lymphoid cells, None) , ( protein: protein tyrosine kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: v-abl, None) , ( DNA: v-abl oncogene, None) , ( cell type: lymphoid cells, None) , ( protein: protein tyrosine kinase, None) " }

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{ "id": "2402", "sentence": "Transformation of bone marrow with the Abelson murine leukemia virus results in the appearance of B cell lineage cells arrested at the pre-B cell stage .", "label": " ( cell type: B cell lineage cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B cell lineage cells, None) " }

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{ "id": "2403", "sentence": "Recent reports have characterized these cells expressing high v-abl kinase activity as deficient in detectable NF-kappaB DNA binding activity and low level RAG gene expression .", "label": " ( DNA: v-abl, None) , ( protein: NF-kappaB, None) , ( DNA: RAG gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: v-abl, None) , ( protein: NF-kappaB, None) , ( DNA: RAG gene, None) " }

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{ "id": "2404", "sentence": "These observations suggest that v-abl may be inhibiting the differentiation of B cells by blocking these two crucial elements in the maturation pathway .", "label": " ( cell type: B cells, None) , ( DNA: v-abl, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: B cells, None) , ( DNA: v-abl, None) " }

[]

{ "id": "2405", "sentence": "Corticosteroid receptors in lymphocytes : a possible marker of brain involution ?", "label": " ( protein: Corticosteroid receptors, None) , ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Corticosteroid receptors, None) , ( cell type: lymphocytes, None) " }

[]

{ "id": "2406", "sentence": "A similarity has recently been found between the regulation of corticosteroid receptors in brain and in lymphoid tissue .", "label": " ( protein: corticosteroid receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: corticosteroid receptors, None) " }

[]

{ "id": "2407", "sentence": "We have studied the regulation of corticosteroid receptors in human mononuclear leukocytes as a possible marker of brain involution .", "label": " ( protein: corticosteroid receptors, None) , ( cell type: human mononuclear leukocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: corticosteroid receptors, None) , ( cell type: human mononuclear leukocytes, None) " }

[]

{ "id": "2408", "sentence": "Type I corticosteroid receptors are down regulated by excess of mineralocorticoids (primary and secondary hyperaldosteronism , pseudohyperaldosteronism ) and of glucocorticoids ( Cushing's syndrome ). Type II corticosteroid receptors are not reduced by excess of endogenous corticosteroids ( Cushing's syndrome ).", "label": " ( protein: Type II corticosteroid receptors, None) , ( protein: corticosteroid receptors, None) , ( protein: corticosteroid receptors, None) , ( protein: Type I corticosteroid receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Type II corticosteroid receptors, None) , ( protein: corticosteroid receptors, None) , ( protein: corticosteroid receptors, None) , ( protein: Type I corticosteroid receptors, None) " }

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{ "id": "2409", "sentence": "In normal adults there is a direct significant correlation between plasma cortisol and Type I and between plasma cortisol and Type II receptors in mononuclear leukocytes , while in Cushing's syndrome the correlation is inverse between plasma cortisol at 8 a.m. and Type II receptors .", "label": " ( protein: Type I, None) , ( cell type: mononuclear leukocytes, None) , ( protein: Type II receptors, None) , ( protein: Type II receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Type I, None) , ( cell type: mononuclear leukocytes, None) , ( protein: Type II receptors, None) , ( protein: Type II receptors, None) " }

[]

{ "id": "2410", "sentence": "In an aged population the mean numbers of Type I and of Type II receptors are lower and plasma cortisol is higher than in adult controls , but the increase of plasma cortisol is not followed by a clinical picture of hypercorticism .", "label": " ( protein: Type II receptors, None) , ( protein: Type I, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Type II receptors, None) , ( protein: Type I, None) " }

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{ "id": "2411", "sentence": "Corticosteroid Type I and Type II receptors are inversely correlated with age.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2412", "sentence": "After dexamethasone suppression (1 mg at 11 p.m.) Type I receptors always decrease in controls while the response of Type II is not homogeneous.", "label": " ( protein: Type I receptors, None) , ( protein: Type II, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Type I receptors, None) , ( protein: Type II, None) " }

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{ "id": "2413", "sentence": "In an aged group of patients , both receptors are reduced by dexamethasone .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2414", "sentence": "We conclude that the decrease with age of corticosteroid receptors is possibly related to a physiological involution of corticosteroid receptors and that this reduction does increase plasma cortisol concentration, without affecting the glucocorticoid effector mechanism .", "label": " ( protein: corticosteroid receptors, None) , ( protein: corticosteroid receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: corticosteroid receptors, None) , ( protein: corticosteroid receptors, None) " }

[]

{ "id": "2415", "sentence": "All-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D3 co-operate to promote differentiation of the human promyeloid leukemia cell line HL60 to monocytes .", "label": " ( cell type: monocytes, None) , ( cell line: human promyeloid leukemia cell line, None) , ( cell line: HL60, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: monocytes, None) , ( cell line: human promyeloid leukemia cell line, None) , ( cell line: HL60, None) " }

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{ "id": "2416", "sentence": "A basis for differentiation therapy of leukemias is provided by knowledge of agents which induce specific lineage maturation.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2417", "sentence": "All-trans retinoic acid ( RA ) induces differentiation of HL60 cells to neutrophils and is used to treat acute promyelocytic leukemia .", "label": " ( cell line: HL60 cells, None) , ( cell type: neutrophils, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL60 cells, None) , ( cell type: neutrophils, None) " }

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{ "id": "2418", "sentence": "We observed that RA did not induced neutrophil differentiation in serum-free grown HL60 cells whereas 50 nM 1 alpha,25-dihydroxyvitamin D3 ( D3 ) induced maximal monocyte differentiation .", "label": " ( cell line: HL60 cells, None) , ( cell line: serum-free grown HL60 cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: HL60 cells, None) , ( cell line: serum-free grown HL60 cells, None) " }

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{ "id": "2419", "sentence": "Increasing RA concentrations reduced the D3 concentration required for monocyte differentiation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2420", "sentence": "Cells treated with 5 nM D3 showed little response, but differentiated maximally with 5 nM D3 and 10 nM RA .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2421", "sentence": "The D3 analogs MC903 , EB1089 and KH1060 were more potent inducers of monocyte differentiation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2422", "sentence": "The extent to which analog activity was increased after cotreatment with RA was inversely related to potency.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2423", "sentence": "Twenty-four hour treatment with 10 nM RA primed cells for response to 5 nM D3 ; the reverse sequence being ineffective.", "label": " ( cell line: RA primed cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: RA primed cells, None) " }

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{ "id": "2424", "sentence": "Priming with 10 nM RA , or subsequent treatment with D3 (5 nM), did not alter expression of mRNAs encoding receptors for D3 ( VDR ), RA ( RAR alpha ) or 9-CIS RA ( RXR alpha , beta , gamma ).", "label": " ( RNA: mRNAs, None) , ( protein: RAR alpha, None) , ( protein: VDR, None) , ( protein: receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: mRNAs, None) , ( protein: RAR alpha, None) , ( protein: VDR, None) , ( protein: receptors, None) " }

[]

{ "id": "2425", "sentence": "That RA promotes both neutrophil and monocyte differentiation has implications for the use of RA and D3 in treatment of leukemias and provides insight into mechanisms whereby RAR, VDR and RXR facilitate monocyte differentiation .", "label": " ( protein: VDR, None) , ( protein: RXR, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: VDR, None) , ( protein: RXR, None) " }

[]

{ "id": "2426", "sentence": "[An overexpression of retinoic acid receptor alpha blocks myeloid cell differentiation at the promyelocyte stage ]", "label": " ( cell type: myeloid cell, None) , ( protein: retinoic acid receptor alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: myeloid cell, None) , ( protein: retinoic acid receptor alpha, None) " }

[]

{ "id": "2427", "sentence": "Retinoic acid ( RA ), a vitamin A derivative , exerts a wide range of biological effects related to cell proliferation and differentiation .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2428", "sentence": "The pleiotropic effects of RA are thought to be mediated through specific nuclear RA receptors ( RARs ).", "label": " ( protein: RA receptors, None) , ( protein: RARs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RA receptors, None) , ( protein: RARs, None) " }

[]

{ "id": "2429", "sentence": "RARs are members of the steroid/thyroid hormone receptor superfamily and exhibit a molecular structure that possess discrete DNA-binding and RA (ligand)-binding domains .", "label": " ( protein: RARs, None) , ( protein: RA (ligand)-binding domains, None) , ( protein: steroid/thyroid hormone receptor superfamily, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RARs, None) , ( protein: RA (ligand)-binding domains, None) , ( protein: steroid/thyroid hormone receptor superfamily, None) " }

[]

{ "id": "2430", "sentence": "In hematopoietic system, RA and RARs , predominantly RAR alpha may play key roles for the proliferation and differentiation of hematopoietic progenitors .", "label": " ( protein: RAR alpha, None) , ( cell type: hematopoietic progenitors, None) , ( protein: RARs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RAR alpha, None) , ( cell type: hematopoietic progenitors, None) , ( protein: RARs, None) " }

[]

{ "id": "2431", "sentence": "However, it is currently unknown how RA and RARs are involved in regulating normal hematopoietic differentiation .", "label": " ( protein: RARs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RARs, None) " }

[]

{ "id": "2432", "sentence": "To make clear the roles of RA and RAR alpha in the normal hematopoiesis , I have introduced the construct of human RAR alpha ( hRAR alpha ) into murine bone marrow cells with retroviral vector , and selected infected cells with drug resistant marker ( Neo(r) ) cultured on the stroma cell line ( PA6-neo ), and analyzed the behavior of infected cells .", "label": " ( cell line: PA6-neo, None) , ( protein: hRAR alpha, None) , ( DNA: drug resistant marker, None) , ( protein: RAR alpha, None) , ( cell line: stroma cell line, None) , ( DNA: Neo(r), None) , ( cell type: infected cells, None) , ( cell type: murine bone marrow cells, None) , ( protein: human RAR alpha, None) , ( protein: RAR alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: PA6-neo, None) , ( protein: hRAR alpha, None) , ( DNA: drug resistant marker, None) , ( protein: RAR alpha, None) , ( cell line: stroma cell line, None) , ( DNA: Neo(r), None) , ( cell type: infected cells, None) , ( cell type: murine bone marrow cells, None) , ( protein: human RAR alpha, None) , ( protein: RAR alpha, None) " }

[]

{ "id": "2433", "sentence": "All of procedure were done in vitro.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2434", "sentence": "Most cells infected with hRAR alpha exhibited promyelocytic morphology and were thought to be blocked at the promyelocytic stage in their myeloid differentiation .", "label": " ( protein: hRAR alpha, None) , ( cell type: promyelocytic morphology, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hRAR alpha, None) , ( cell type: promyelocytic morphology, None) " }

[]

{ "id": "2435", "sentence": "Furthermore, these immature cells differentiated terminally into mature granulocytes by adding with RA (10(-6) M).", "label": " ( cell type: immature cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: immature cells, None) " }

[]

{ "id": "2436", "sentence": "RAR alpha infected cells were also able to differentiate into mature macrophages in the both of long term culture and IL3 colony .", "label": " ( cell type: infected cells, None) , ( cell line: IL3 colony, None) , ( cell type: mature macrophages, None) , ( protein: RAR alpha, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: infected cells, None) , ( cell line: IL3 colony, None) , ( cell type: mature macrophages, None) , ( protein: RAR alpha, None) " }

[]

{ "id": "2437", "sentence": "These observations suggest that an overexpression of RAR alpha alone is effective to suppress myeloid cell differentiation and RAR alpha plays a crucial role in the terminal differentiation of myeloid precursors.", "label": " ( protein: RAR alpha, None) , ( protein: RAR alpha, None) , ( cell type: myeloid cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: RAR alpha, None) , ( protein: RAR alpha, None) , ( cell type: myeloid cell, None) " }

[]

{ "id": "2438", "sentence": "The system described here may serve as a model for studying the the essential genes for differentiation of normal bone marrow cells .", "label": " ( cell type: normal bone marrow cells, None) , ( DNA: essential genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: normal bone marrow cells, None) , ( DNA: essential genes, None) " }

[]

{ "id": "2439", "sentence": "Hypoxic induction of interleukin-8 gene expression in human endothelial cells .", "label": " ( protein: interleukin-8, None) , ( cell type: human endothelial cells, None) , ( DNA: interleukin-8 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: interleukin-8, None) , ( cell type: human endothelial cells, None) , ( DNA: interleukin-8 gene, None) " }

[]

{ "id": "2440", "sentence": "Because leukocyte-mediated tissue damage is an important component of the pathologic picture in ischemia/reperfusion , we have sought mechanisms by which PMNs are directed into hypoxic tissue .", "label": " ( cell type: PMNs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: PMNs, None) " }

[]

{ "id": "2441", "sentence": "Incubation of human endothelial cells ( ECs ) in hypoxia , PO2 approximately 14-18 Torr, led to time-dependent release of IL-8 antigen into the conditioned medium; this was accompanied by increased chemotactic activity for PMNs , blocked by antibody to IL-8 .", "label": " ( cell type: ECs, None) , ( protein: IL-8, None) , ( cell type: human endothelial cells, None) , ( protein: IL-8, None) , ( cell type: PMNs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: ECs, None) , ( protein: IL-8, None) , ( cell type: human endothelial cells, None) , ( protein: IL-8, None) , ( cell type: PMNs, None) " }

[]

{ "id": "2442", "sentence": "Production of IL-8 by hypoxic ECs occurred concomitantly with both increased levels of IL-8 mRNA , based on polymerase chain reaction analysis , and increased IL-8 transcription , based on nuclear run-on assays .", "label": " ( RNA: IL-8 mRNA, None) , ( protein: IL-8, None) , ( cell type: ECs, None) , ( protein: IL-8, None) , ( protein: IL-8, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: IL-8 mRNA, None) , ( protein: IL-8, None) , ( cell type: ECs, None) , ( protein: IL-8, None) , ( protein: IL-8, None) " }

[]

{ "id": "2443", "sentence": "Northern analysis of mRNA from hypoxic ECs also demonstrated increased levels of mRNA for macrophage chemotactic protein-1 , another member of the chemokine superfamily of proinflammatory cytokines .", "label": " ( cell type: ECs, None) , ( protein: macrophage chemotactic protein-1, None) , ( protein: proinflammatory cytokines, None) , ( RNA: mRNA, None) , ( protein: chemokine superfamily, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: ECs, None) , ( protein: macrophage chemotactic protein-1, None) , ( protein: proinflammatory cytokines, None) , ( RNA: mRNA, None) , ( protein: chemokine superfamily, None) " }

[]

{ "id": "2444", "sentence": "IL-8 gene induction was associated with the presence of increased binding activity in nuclear extracts from hypoxic ECs for the NF-kB site.", "label": " ( cell type: ECs, None) , ( cell type: hypoxic ECs, None) , ( protein: IL-8, None) , ( DNA: IL-8 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: ECs, None) , ( cell type: hypoxic ECs, None) , ( protein: IL-8, None) , ( DNA: IL-8 gene, None) " }

[]

{ "id": "2445", "sentence": "Studies with human umbilical vein segments exposed to hypoxia also demonstrated increased elaboration of IL-8 antigen compared with normoxic controls.", "label": " ( protein: IL-8, None) , ( protein: IL-8 antigen, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-8, None) , ( protein: IL-8 antigen, None) " }

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{ "id": "2446", "sentence": "In mice exposed to hypoxia (PO2 approximately 30-40 Torr), there was increased pulmonary leukostasis, as evidenced by increased myeloperoxidase activity in tissue homogenates .", "label": " ( protein: myeloperoxidase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: myeloperoxidase, None) " }

[]

{ "id": "2447", "sentence": "In parallel, increased levels of transcripts for IP-10 , a murine homologue in the chemokine family related to IL-8 , were observed in hypoxic lung tissue .", "label": " ( protein: IP-10, None) , ( protein: IL-8, None) , ( protein: chemokine family, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IP-10, None) , ( protein: IL-8, None) , ( protein: chemokine family, None) " }

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{ "id": "2448", "sentence": "Taken together, these data suggest that hypoxia constitutes a stimulus for leukocyte chemotaxis and tissue leukostasis .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2449", "sentence": "Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production.", "label": " ( protein: TCR, None) , ( protein: CD69, None) , ( protein: Thrombin, None) , ( protein: thrombin receptor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TCR, None) , ( protein: CD69, None) , ( protein: Thrombin, None) , ( protein: thrombin receptor, None) " }

[]

{ "id": "2450", "sentence": "Thrombin stimulation of the T leukemic cell line Jurkat induced a transient increase in [ Ca2+ ]i .", "label": " ( protein: Thrombin, None) , ( cell line: T leukemic cell line Jurkat, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Thrombin, None) , ( cell line: T leukemic cell line Jurkat, None) " }

[]

{ "id": "2451", "sentence": "Proteolytic activity of the enzyme was required for this effect since diisopropyl fluorophosphate-thrombin failed to increase [ Ca2+ ]i .", "label": " ( protein: diisopropyl fluorophosphate-thrombin, None) , ( protein: enzyme, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: diisopropyl fluorophosphate-thrombin, None) , ( protein: enzyme, None) " }

[]

{ "id": "2452", "sentence": "Furthermore, hirudin and anti-thrombin III inhibited the thrombin-induced [ Ca2+ ]i rise in Jurkat T cells .", "label": " ( cell line: Jurkat T cells, None) , ( protein: anti-thrombin III, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Jurkat T cells, None) , ( protein: anti-thrombin III, None) " }

[]

{ "id": "2453", "sentence": "A synthetic thrombin receptor agonist peptide ( TRP ) of 7 residues ( SFLLRNP ) was found to be as effective as thrombin for [ Ca2+ ]i mobilization, and both agonists induced Ca2+ release exclusively from internal stores .", "label": " ( protein: thrombin receptor, None) , ( protein: thrombin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: thrombin receptor, None) , ( protein: thrombin, None) " }

[]

{ "id": "2454", "sentence": "Thrombin stimulated tyrosine phosphorylation of several proteins of molecular mass 40 , 42 , 70 , 120 , and 130 kDa .", "label": " ( protein: Thrombin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Thrombin, None) " }

[]

{ "id": "2455", "sentence": "There was a good correlation between thrombin -induced tyrosine phosphorylation of the latter three proteins and Ca2+ mobilization .", "label": " ( protein: thrombin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: thrombin, None) " }

[]

{ "id": "2456", "sentence": "Thrombin and TRP also caused translocation of protein kinase C from the cytosol to the plasma membrane .", "label": " ( protein: Thrombin, None) , ( protein: protein kinase C, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Thrombin, None) , ( protein: protein kinase C, None) " }

[]

{ "id": "2457", "sentence": "As a likely consequence of these events, thrombin activated the nuclear factor NF-kB .", "label": " ( protein: thrombin, None) , ( protein: nuclear factor NF-kB, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: thrombin, None) , ( protein: nuclear factor NF-kB, None) " }

[]

{ "id": "2458", "sentence": "Several cell lines of hematopoietic origin including the leukemic T cell line HPB.ALL and the erythroleukemic cell line K562 were responsive to thrombin , whereas others such as THP1 , a myelomonocytic cell line , and BL2, a Burkitt lymphoma were refractory to thrombin or TRP stimulation.", "label": " ( cell line: THP1, None) , ( cell line: BL2,, None) , ( cell line: erythroleukemic cell line K562, None) , ( protein: thrombin, None) , ( cell line: Burkitt lymphoma, None) , ( protein: thrombin, None) , ( cell line: leukemic T cell line HPB.ALL, None) , ( cell line: myelomonocytic cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: THP1, None) , ( cell line: BL2,, None) , ( cell line: erythroleukemic cell line K562, None) , ( protein: thrombin, None) , ( cell line: Burkitt lymphoma, None) , ( protein: thrombin, None) , ( cell line: leukemic T cell line HPB.ALL, None) , ( cell line: myelomonocytic cell line, None) " }

[]

{ "id": "2459", "sentence": "The magnitude of the thrombin response in the different cell types paralleled the expression of the thrombin receptor mRNA .", "label": " ( protein: thrombin receptor, None) , ( protein: thrombin, None) , ( protein: thrombin, None) , ( RNA: thrombin receptor mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: thrombin receptor, None) , ( protein: thrombin, None) , ( protein: thrombin, None) , ( RNA: thrombin receptor mRNA, None) " }

[]

{ "id": "2460", "sentence": "We found that activation of Jurkat T cells by a combination of phytohemagglutinin and phorbol 12-myristate 13-acetate led to a dramatic inhibition of thrombin receptor mRNA expression and to a concomitant loss of the thrombin response .", "label": " ( protein: thrombin, None) , ( cell line: Jurkat T cells, None) , ( RNA: thrombin receptor mRNA, None) , ( protein: thrombin receptor, None) , ( protein: thrombin, None) , ( protein: phytohemagglutinin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: thrombin, None) , ( cell line: Jurkat T cells, None) , ( RNA: thrombin receptor mRNA, None) , ( protein: thrombin receptor, None) , ( protein: thrombin, None) , ( protein: phytohemagglutinin, None) " }

[]

{ "id": "2461", "sentence": "Finally, we demonstrate that thrombin and TRP enhanced CD69 expression and interleukin 2 production induced by T cell receptor cross-linking in both Jurkat T cells and peripheral blood lymphocytes .", "label": " ( cell type: lymphocytes, None) , ( protein: thrombin, None) , ( protein: T cell receptor, None) , ( protein: CD69, None) , ( protein: interleukin 2, None) , ( cell line: Jurkat T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphocytes, None) , ( protein: thrombin, None) , ( protein: T cell receptor, None) , ( protein: CD69, None) , ( protein: interleukin 2, None) , ( cell line: Jurkat T cells, None) " }

[]

{ "id": "2462", "sentence": "These findings highlight the role of thrombin as a potential regulator of T lymphocyte activation .", "label": " ( cell type: T lymphocyte, None) , ( protein: thrombin, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T lymphocyte, None) , ( protein: thrombin, None) " }

[]

{ "id": "2463", "sentence": "Stress response of senescent T lymphocytes : reduced hsp70 is independent of the proliferative block .", "label": " ( protein: hsp70, None) , ( cell type: senescent T lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: hsp70, None) , ( cell type: senescent T lymphocytes, None) " }

[]

{ "id": "2464", "sentence": "Senescent human T lymphocyte cultures are unable to undergo proliferation, but show no difference from early passage cells in cytotoxic function or surface antigenic profile .", "label": " ( cell line: Senescent human T lymphocyte cultures, None) , ( cell line: early passage cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Senescent human T lymphocyte cultures, None) , ( cell line: early passage cells, None) " }

[]

{ "id": "2465", "sentence": "A second feature of senescent T cells is the dramatic reduction in hsp70 production in response to heat shock .", "label": " ( cell line: senescent T cells, None) , ( protein: hsp70, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: senescent T cells, None) , ( protein: hsp70, None) " }

[]

{ "id": "2466", "sentence": "This decline is associated with a decrease in binding of nuclear extracts to the consensus heat shock element .", "label": " ( DNA: consensus heat shock element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: consensus heat shock element, None) " }

[]

{ "id": "2467", "sentence": "Interestingly, the progressive decline in the heat shock response of cultured T cells correlates with the percent proliferative life span completed rather than with the actual proliferative activity at the time of heat shock .", "label": " ( cell line: cultured T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: cultured T cells, None) " }

[]

{ "id": "2468", "sentence": "This suggests that for senescent T cells the reduced ability to respond to heat shock by producing hsp70 , although possibly lying at the level of transcriptional control , may nevertheless be unrelated to the reduced DNA synthesis or the diminished proliferative activity also manifested by these cells.", "label": " ( cell type: senescent T cells, None) , ( DNA: DNA, None) , ( protein: hsp70, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: senescent T cells, None) , ( DNA: DNA, None) , ( protein: hsp70, None) " }

[]

{ "id": "2469", "sentence": "Involvement of phospholipase D in the activation of transcription factor AP-1 in human T lymphoid Jurkat cells .", "label": " ( protein: transcription factor AP-1, None) , ( cell line: human T lymphoid Jurkat cells, None) , ( cell line: Jurkat cells, None) , ( protein: phospholipase D, None) , ( protein: AP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor AP-1, None) , ( cell line: human T lymphoid Jurkat cells, None) , ( cell line: Jurkat cells, None) , ( protein: phospholipase D, None) , ( protein: AP-1, None) " }

[]

{ "id": "2470", "sentence": "The induction of the AP-1 transcription factor has been ascribed to the early events leading to T lymphocyte activation .", "label": " ( protein: transcription factor, None) , ( protein: AP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor, None) , ( protein: AP-1, None) " }

[]

{ "id": "2471", "sentence": "We have examined the possibility that stimulation of phospholipase D ( PLD ) may regulate activation of transcription factor AP-1 in human T cells by transfecting human T lymphocyte Jurkat cells with a plasmid containing an AP-1 enhancer element and a chloramphenicol acetyltransferase reporter gene .", "label": " ( DNA: AP-1 enhancer, None) , ( protein: AP-1, None) , ( protein: phospholipase D, None) , ( DNA: AP-1 enhancer element, None) , ( DNA: chloramphenicol acetyltransferase reporter gene, None) , ( protein: transcription factor AP-1, None) , ( cell line: T lymphocyte Jurkat cells, None) , ( cell line: Jurkat cells, None) , ( protein: PLD, None) , ( protein: chloramphenicol acetyltransferase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: AP-1 enhancer, None) , ( protein: AP-1, None) , ( protein: phospholipase D, None) , ( DNA: AP-1 enhancer element, None) , ( DNA: chloramphenicol acetyltransferase reporter gene, None) , ( protein: transcription factor AP-1, None) , ( cell line: T lymphocyte Jurkat cells, None) , ( cell line: Jurkat cells, None) , ( protein: PLD, None) , ( protein: chloramphenicol acetyltransferase, None) " }

[]

{ "id": "2472", "sentence": "We have detected activatable PLD in Jurkat cells , and we have found that addition of phosphatidic acid ( PA ), the physiologic product of PLD action on phospholipids , is rapidly incorporated into Jurkat cells and leads to activation of transcription factor AP-1 .", "label": " ( protein: transcription factor AP-1, None) , ( protein: PLD, None) , ( cell line: Jurkat cells, None) , ( protein: AP-1, None) , ( protein: PLD, None) , ( cell line: Jurkat cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor AP-1, None) , ( protein: PLD, None) , ( cell line: Jurkat cells, None) , ( protein: AP-1, None) , ( protein: PLD, None) , ( cell line: Jurkat cells, None) " }

[]

{ "id": "2473", "sentence": "Treatment of Jurkat cells with anti-CD3 mAb activated both PLD and transcription factor AP-1 .", "label": " ( protein: PLD, None) , ( protein: anti-CD3 mAb, None) , ( protein: AP-1, None) , ( cell line: Jurkat cells, None) , ( protein: transcription factor AP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PLD, None) , ( protein: anti-CD3 mAb, None) , ( protein: AP-1, None) , ( cell line: Jurkat cells, None) , ( protein: transcription factor AP-1, None) " }

[]

{ "id": "2474", "sentence": "Wortmannin, an inhibitor of receptor-coupled PLD activation, blocked the anti-CD3 -induced increases in both PLD activity and AP-1 enhancer activity .", "label": " ( protein: PLD, None) , ( protein: anti-CD3, None) , ( DNA: AP-1 enhancer, None) , ( protein: PLD, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PLD, None) , ( protein: anti-CD3, None) , ( DNA: AP-1 enhancer, None) , ( protein: PLD, None) " }

[]

{ "id": "2475", "sentence": "We found a good correlation in the transfected cells between PLD activation and induction of AP-1 enhancer activity under different experimental conditions.", "label": " ( cell line: transfected cells, None) , ( DNA: AP-1 enhancer, None) , ( protein: PLD, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: transfected cells, None) , ( DNA: AP-1 enhancer, None) , ( protein: PLD, None) " }

[]

{ "id": "2476", "sentence": "Furthermore, ethanol , an inhibitor of the PLD pathway, blocked the anti-CD3-stimulated AP-1 enhancer activity .", "label": " ( DNA: AP-1 enhancer, None) , ( protein: PLD, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: AP-1 enhancer, None) , ( protein: PLD, None) " }

[]

{ "id": "2477", "sentence": "However, this anti-CD3 -mediated response was not inhibited by neomycin , an inhibitor of phosphoinositide hydrolysis .", "label": " ( protein: anti-CD3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti-CD3, None) " }

[]

{ "id": "2478", "sentence": "The increases in AP-1 enhancer activity induced by PA or anti-CD3 mAb were efficiently abrogated by the presence of propranolol , an inhibitor of PA phosphohydrolase and protein kinase C ( PKC ).", "label": " ( DNA: AP-1 enhancer, None) , ( protein: PKC, None) , ( protein: anti-CD3 mAb, None) , ( protein: phosphohydrolase, None) , ( protein: protein kinase C, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: AP-1 enhancer, None) , ( protein: PKC, None) , ( protein: anti-CD3 mAb, None) , ( protein: phosphohydrolase, None) , ( protein: protein kinase C, None) " }

[]

{ "id": "2479", "sentence": "Furthermore, the PA -and the anti-CD3 -induced increases in AP-1 enhancer activity were blocked by the presence of PKC inhibitors or by PKC down-regulation .", "label": " ( protein: PKC, None) , ( DNA: AP-1 enhancer, None) , ( protein: anti-CD3, None) , ( protein: PKC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: PKC, None) , ( DNA: AP-1 enhancer, None) , ( protein: anti-CD3, None) , ( protein: PKC, None) " }

[]

{ "id": "2480", "sentence": "These data indicate that PLD stimulation can activate the transcription factor AP-1 in T lymphocytes , and suggest that the induction of AP-1 enhancer factor activity by PA is mediated via PKC stimulation , either through a direct activating effect of PA or through PA -derived diacylglycerol formation .", "label": " ( cell type: T lymphocytes, None) , ( protein: PLD, None) , ( DNA: AP-1 enhancer, None) , ( protein: PKC, None) , ( protein: AP-1, None) , ( protein: transcription factor AP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T lymphocytes, None) , ( protein: PLD, None) , ( DNA: AP-1 enhancer, None) , ( protein: PKC, None) , ( protein: AP-1, None) , ( protein: transcription factor AP-1, None) " }

[]

{ "id": "2481", "sentence": "These data also provide evidence for a role of PLD -derived lipids in the induction of AP-1 enhancer activity resulting from stimulation of the TCR/CD3 complex , suggesting that increased PLD activity can play an important role in T lymphocyte activation .", "label": " ( protein: TCR/CD3 complex, None) , ( protein: PLD, None) , ( DNA: AP-1 enhancer, None) , ( protein: PLD, None) , ( cell type: T lymphocyte, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TCR/CD3 complex, None) , ( protein: PLD, None) , ( DNA: AP-1 enhancer, None) , ( protein: PLD, None) , ( cell type: T lymphocyte, None) " }

[]

{ "id": "2482", "sentence": "Upregulation of bcl-2 by the Epstein-Barr virus latent membrane protein LMP1 : a B-cell-specific response that is delayed relative to NF-kappa B activation and to induction of cell surface markers .", "label": " ( protein: Epstein-Barr virus latent membrane protein, None) , ( protein: cell surface markers, None) , ( protein: NF-kappa B, None) , ( DNA: bcl-2, None) , ( protein: LMP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Epstein-Barr virus latent membrane protein, None) , ( protein: cell surface markers, None) , ( protein: NF-kappa B, None) , ( DNA: bcl-2, None) , ( protein: LMP1, None) " }

[]

{ "id": "2483", "sentence": "An ability of the Epstein-Barr virus latent membrane protein LMP1 to enhance the survival of infected B cells through upregulation of the bcl-2 oncogene was first suggested by experiments involving gene transfection and the selection of stable LMP1 + clones (S.Henderson, M. Rowe, C.Gregory, F.Wang, E.Kieff, and A.Rickinson, Cell 65:1107-1115, 1991).", "label": " ( DNA: bcl-2, None) , ( protein: LMP1, None) , ( protein: Epstein-Barr virus latent membrane protein, None) , ( cell type: infected B cells, None) , ( cell line: LMP1 + clones, None) , ( DNA: bcl-2 oncogene, None) , ( protein: LMP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: bcl-2, None) , ( protein: LMP1, None) , ( protein: Epstein-Barr virus latent membrane protein, None) , ( cell type: infected B cells, None) , ( cell line: LMP1 + clones, None) , ( DNA: bcl-2 oncogene, None) , ( protein: LMP1, None) " }

[]

{ "id": "2484", "sentence": "However, it was not possible to ascertain whether Bcl-2 upregulation was a specific consequence of LMP1 expression or an artifact of the selection procedure whereby rare Bcl-2 + cells already present in the starting population might best be able to tolerate the potentially toxic effects of LMP1 .", "label": " ( protein: Bcl-2, None) , ( protein: LMP1, None) , ( cell line: Bcl-2 + cells, None) , ( protein: Bcl-2, None) , ( protein: LMP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Bcl-2, None) , ( protein: LMP1, None) , ( cell line: Bcl-2 + cells, None) , ( protein: Bcl-2, None) , ( protein: LMP1, None) " }

[]

{ "id": "2485", "sentence": "We therefore reexamined this issue by using two different experimental approaches that allowed LMP1 -induced effects to be monitored immediately following expression of the viral protein and in the absence of selective pressures; activation of the NF-kappa B transcription factor and upregulation of the cell adhesion molecule ICAM-1 were used as early indices of LMP1 function.", "label": " ( protein: transcription factor, None) , ( protein: LMP1, None) , ( protein: cell adhesion molecule, None) , ( protein: LMP1, None) , ( protein: NF-kappa B, None) , ( protein: ICAM-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: transcription factor, None) , ( protein: LMP1, None) , ( protein: cell adhesion molecule, None) , ( protein: LMP1, None) , ( protein: NF-kappa B, None) , ( protein: ICAM-1, None) " }

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{ "id": "2486", "sentence": "In the first approach, stable clones of two B-cell lines carrying an LMP1 gene under the control of an inducible metallothionein promoter were induced to express LMP1 in all cells.", "label": " ( protein: LMP1, None) , ( protein: LMP1, None) , ( cell line: B-cell lines, None) , ( DNA: metallothionein promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LMP1, None) , ( protein: LMP1, None) , ( cell line: B-cell lines, None) , ( DNA: metallothionein promoter, None) " }

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{ "id": "2487", "sentence": "Activation of NK-kappa B and upregulation of ICAM-1 occurred within 24 h and were followed at 48 to 72 h by upregulation of Bcl-2 .", "label": " ( protein: Bcl-2, None) , ( protein: ICAM-1, None) , ( protein: NK-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Bcl-2, None) , ( protein: ICAM-1, None) , ( protein: NK-kappa B, None) " }

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{ "id": "2488", "sentence": "In the second approach, we tested the generality of this phenomenon by transiently expressing LMP1 from a strong constitutively active promoter in a range of different cell types.", "label": " ( protein: LMP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LMP1, None) " }

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{ "id": "2489", "sentence": "All six B-cell lines tested showed NF-kappa B activation in response to LMP1 expression , and this was followed in five of six lines by expression of ICAM-1 and Bcl-2 .", "label": " ( protein: ICAM-1, None) , ( protein: LMP1, None) , ( protein: NF-kappa B, None) , ( protein: Bcl-2, None) , ( cell line: B-cell lines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: ICAM-1, None) , ( protein: LMP1, None) , ( protein: NF-kappa B, None) , ( protein: Bcl-2, None) , ( cell line: B-cell lines, None) " }

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{ "id": "2490", "sentence": "In the same experiments, all three non- B-cell lines showed NF-kappa B activation and ICAM-1 upregulation but never any effect upon Bcl-2 .", "label": " ( protein: NF-kappa B, None) , ( protein: ICAM-1, None) , ( cell line: B-cell lines, None) , ( protein: Bcl-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: ICAM-1, None) , ( cell line: B-cell lines, None) , ( protein: Bcl-2, None) " }

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{ "id": "2491", "sentence": "We therefore conclude that Bcl-2 upregulation is part of the panoply of cellular changes induced by LMP1 but that the effect is cell type specific.", "label": " ( protein: Bcl-2, None) , ( protein: LMP1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: Bcl-2, None) , ( protein: LMP1, None) " }

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{ "id": "2492", "sentence": "Our data also suggest that whilst NF-kappa B may be an essential component of LMP1 signal transduction , other cell-specific factors may be required to effect some functions of the viral protein .", "label": " ( protein: NF-kappa B, None) , ( protein: LMP1, None) , ( protein: viral protein, None) , ( protein: cell-specific factors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kappa B, None) , ( protein: LMP1, None) , ( protein: viral protein, None) , ( protein: cell-specific factors, None) " }

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{ "id": "2493", "sentence": "Long-term inositol phosphate release , but not tyrosine kinase activity , correlates with IL-2 secretion and NF-AT induction in anti-CD3-activated peripheral human T lymphocytes .", "label": " ( protein: NF-AT, None) , ( protein: IL-2, None) , ( cell line: anti-CD3-activated peripheral human T lymphocytes, None) , ( protein: tyrosine kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT, None) , ( protein: IL-2, None) , ( cell line: anti-CD3-activated peripheral human T lymphocytes, None) , ( protein: tyrosine kinase, None) " }

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{ "id": "2494", "sentence": "The cascade of events within the first few minutes of T cell stimulation has been well characterized.", "label": " ( cell type: T cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cell, None) " }

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{ "id": "2495", "sentence": "Although many second messengers have been shown to be necessary and sufficient for T cell activation in a number of model systems, the rate-limiting step in peripheral T cells has not been demonstrated.", "label": " ( cell type: T cell, None) , ( cell type: peripheral T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cell, None) , ( cell type: peripheral T cells, None) " }

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{ "id": "2496", "sentence": "To model effective versus ineffective CD3 -mediated stimulation in peripheral T cells , we used two anti-CD3 mAbs that differ in their ability to stimulate purified T cells : OKT3 , which causes early second messenger generation but is unable to activate T cells without a second signal, and 64.1 , which stimulates T cell proliferation on its own.", "label": " ( protein: CD3, None) , ( cell type: purified T cells, None) , ( protein: 64.1, None) , ( cell type: peripheral T cells, None) , ( cell type: T cell, None) , ( cell type: T cells, None) , ( protein: anti-CD3 mAbs, None) , ( protein: OKT3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD3, None) , ( cell type: purified T cells, None) , ( protein: 64.1, None) , ( cell type: peripheral T cells, None) , ( cell type: T cell, None) , ( cell type: T cells, None) , ( protein: anti-CD3 mAbs, None) , ( protein: OKT3, None) " }

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{ "id": "2497", "sentence": "We found that tyrosine kinase activity was similar for both mAbs over a period of hours.", "label": " ( protein: mAbs, None) , ( protein: tyrosine kinase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: mAbs, None) , ( protein: tyrosine kinase, None) " }

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{ "id": "2498", "sentence": "However, the inositol phosphate response was stronger for 64.1 than for OKT3 .", "label": " ( protein: 64.1, None) , ( protein: OKT3, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: 64.1, None) , ( protein: OKT3, None) " }

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{ "id": "2499", "sentence": "To tie these events to gene activation , we measured NF-kappa B and NF-AT activity in the nucleus after anti-CD3 stimulation .", "label": " ( protein: NF-AT, None) , ( protein: anti-CD3, None) , ( protein: NF-kappa B, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-AT, None) , ( protein: anti-CD3, None) , ( protein: NF-kappa B, None) " }