Datasets:

huy-nh-2000

/

instructUIE

like 0

[]

{ "id": "2300", "sentence": "Pathological evaluation revealed a high-grade vulvar leiomyosarcoma .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2301", "sentence": "Immunohistochemical and ultrastructural studies were performed to support the diagnosis.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2302", "sentence": "In an effort to better understand the biology of this tumor additional immunohistochemical studies for the protein product of p53 tumor suppressor gene and estrogen receptor expression by tumor cells , as well as the type of immune cells infiltrating the tumor were performed.", "label": " ( protein: protein product, None) , ( protein: estrogen receptor, None) , ( cell type: tumor cells, None) , ( cell type: immune cells, None) , ( DNA: p53 tumor suppressor gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: protein product, None) , ( protein: estrogen receptor, None) , ( cell type: tumor cells, None) , ( cell type: immune cells, None) , ( DNA: p53 tumor suppressor gene, None) " }

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{ "id": "2303", "sentence": "Tumor cells showed an overexpression of p53 protein and were estrogen receptor -positive .", "label": " ( protein: estrogen receptor, None) , ( protein: p53 protein, None) , ( cell type: Tumor cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: estrogen receptor, None) , ( protein: p53 protein, None) , ( cell type: Tumor cells, None) " }

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{ "id": "2304", "sentence": "Macrophages and T and B lymphocytes infiltrated the tumor in moderate numbers with occasional lymphoid aggregate formation .", "label": " ( cell type: Macrophages, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: Macrophages, None) " }

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{ "id": "2305", "sentence": "This study is the first attempt to better understand the biology of these tumors .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2306", "sentence": "Stimulation of HIV replication in mononuclear phagocytes by leukemia inhibitory factor .", "label": " ( cell type: mononuclear phagocytes, None) , ( protein: leukemia inhibitory factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: mononuclear phagocytes, None) , ( protein: leukemia inhibitory factor, None) " }

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{ "id": "2307", "sentence": "This study examined the effects of leukemia inhibitory factor ( LIF ) on human immunodeficiency virus ( HIV ) replication in mononuclear phagocytes ( MNP ).", "label": " ( cell type: mononuclear phagocytes, None) , ( protein: LIF, None) , ( cell type: MNP, None) , ( protein: leukemia inhibitory factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: mononuclear phagocytes, None) , ( protein: LIF, None) , ( cell type: MNP, None) , ( protein: leukemia inhibitory factor, None) " }

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{ "id": "2308", "sentence": "LIF induced a dose-dependent increase in p24 antigen production in the chronically infected promonocytic cell line U1 .", "label": " ( cell line: chronically infected promonocytic cell line U1, None) , ( protein: p24 antigen, None) , ( protein: LIF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: chronically infected promonocytic cell line U1, None) , ( protein: p24 antigen, None) , ( protein: LIF, None) " }

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{ "id": "2309", "sentence": "The magnitude and time kinetics of the LIF effects were similar to interleukin 1 ( IL-1 ), IL-6 , and tumor necrosis factor ( TNF ), other cytokines known to induce HIV replication in this cell line.", "label": " ( protein: TNF, None) , ( protein: IL-1, None) , ( protein: LIF, None) , ( protein: tumor necrosis factor, None) , ( protein: interleukin 1, None) , ( protein: IL-6, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: TNF, None) , ( protein: IL-1, None) , ( protein: LIF, None) , ( protein: tumor necrosis factor, None) , ( protein: interleukin 1, None) , ( protein: IL-6, None) " }

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{ "id": "2310", "sentence": "To characterize mechanisms responsible for these LIF effects , levels of HIV mRNA , activation of the DNA binding protein nuclear factor (NF)-kB , signal transduction pathways , and potential interactions with other cytokines were analyzed.", "label": " ( protein: (NF)-kB, None) , ( protein: DNA binding protein nuclear factor, None) , ( RNA: HIV mRNA, None) , ( protein: cytokines, None) , ( protein: LIF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: (NF)-kB, None) , ( protein: DNA binding protein nuclear factor, None) , ( RNA: HIV mRNA, None) , ( protein: cytokines, None) , ( protein: LIF, None) " }

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{ "id": "2311", "sentence": "LIF increased steady-state levels of HIV mRNA at 2.0, 4.3, and 9.2 kB.", "label": " ( protein: LIF, None) , ( RNA: HIV mRNA, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LIF, None) , ( RNA: HIV mRNA, None) " }

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{ "id": "2312", "sentence": "This was detectable by 24 h and persisted until 72 h.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2313", "sentence": "The DNA binding protein NF-kB is a central mediator in cytokine activation of HIV transcription .", "label": " ( protein: DNA binding protein NF-kB, None) , ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: DNA binding protein NF-kB, None) , ( protein: cytokine, None) " }

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{ "id": "2314", "sentence": "NF-kB levels were higher in unstimulated U1 cells as compared to the parent cell line U937 .", "label": " ( cell line: U937, None) , ( cell line: unstimulated U1 cells, None) , ( protein: NF-kB, None) , ( cell line: parent cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: U937, None) , ( cell line: unstimulated U1 cells, None) , ( protein: NF-kB, None) , ( cell line: parent cell line, None) " }

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{ "id": "2315", "sentence": "In both cell lines LIF increased NF-kB activity .", "label": " ( protein: NF-kB, None) , ( protein: LIF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kB, None) , ( protein: LIF, None) " }

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{ "id": "2316", "sentence": "Induction of NF-kB and HIV replication by cytokines are at least in part dependent on reactive oxygen intermediates .", "label": " ( protein: NF-kB, None) , ( protein: cytokines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: NF-kB, None) , ( protein: cytokines, None) " }

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{ "id": "2317", "sentence": "The oxygen radical scavenger N-acetyl-L-cysteine , but not an inhibitor of nitric oxide synthase , inhibited LIF -induced HIV replication .", "label": " ( protein: nitric oxide synthase, None) , ( protein: LIF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: nitric oxide synthase, None) , ( protein: LIF, None) " }

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{ "id": "2318", "sentence": "LIF induces the production of other cytokines in monocytes but its effects on HIV replication were not inhibited by antibodies to IL-1 , TNF , or IL-6 .", "label": " ( protein: IL-6, None) , ( protein: LIF, None) , ( protein: antibodies, None) , ( protein: IL-1, None) , ( protein: TNF, None) , ( protein: cytokines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-6, None) , ( protein: LIF, None) , ( protein: antibodies, None) , ( protein: IL-1, None) , ( protein: TNF, None) , ( protein: cytokines, None) " }

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{ "id": "2319", "sentence": "These results identify LIF as a stimulus of HIV replication .", "label": " ( protein: LIF, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: LIF, None) " }

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{ "id": "2320", "sentence": "(ABSTRACT TRUNCATED AT 250 WORDS)", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2321", "sentence": "Mechanisms involved in the inhibition of growth of a human B lymphoma cell line , B104 , by anti-MHC class II antibodies .", "label": " ( cell line: B104, None) , ( protein: anti-MHC class II antibodies, None) , ( cell line: human B lymphoma cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: B104, None) , ( protein: anti-MHC class II antibodies, None) , ( cell line: human B lymphoma cell line, None) " }

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{ "id": "2322", "sentence": "The mechanisms involved in the inhibition of growth of a human B lymphoma cell line , B104 , by anti-MHC class II antibodies ( Ab ) were compared with those in anti-IgM Ab -induced B104 growth inhibition .", "label": " ( protein: anti-IgM Ab, None) , ( protein: anti-MHC class II antibodies, None) , ( cell line: B104, None) , ( protein: Ab, None) , ( cell line: human B lymphoma cell line, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti-IgM Ab, None) , ( protein: anti-MHC class II antibodies, None) , ( cell line: B104, None) , ( protein: Ab, None) , ( cell line: human B lymphoma cell line, None) " }

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{ "id": "2323", "sentence": "Two anti-MHC class II Ab , L227 and 2.06 , inhibited the growth of B104 cells , although 2.06 , but not L227 , needed to be further cross-linked with a goat anti-mouse IgG Ab ( GAM ) to show the effect.", "label": " ( protein: L227, None) , ( protein: anti-MHC class II Ab, None) , ( protein: L227, None) , ( protein: 2.06, None) , ( protein: goat anti-mouse IgG Ab, None) , ( cell line: B104 cells, None) , ( protein: 2.06, None) , ( protein: GAM, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: L227, None) , ( protein: anti-MHC class II Ab, None) , ( protein: L227, None) , ( protein: 2.06, None) , ( protein: goat anti-mouse IgG Ab, None) , ( cell line: B104 cells, None) , ( protein: 2.06, None) , ( protein: GAM, None) " }

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{ "id": "2324", "sentence": "L227 induced an increase in intracellular free Ca2+ concentration ( [ Ca2+ ]i ) from the intracellular pool and little or no protein tyrosine phosphorylation , phosphatidyl inositol turnover , or expression of Egr-1 mRNA , whereas 2.06 plus GAM induced an increase in [ Ca2+ ]i from both the intracellular and, in particular, the extracellular pools .", "label": " ( protein: 2.06, None) , ( RNA: Egr-1 mRNA, None) , ( protein: GAM, None) , ( protein: L227, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: 2.06, None) , ( RNA: Egr-1 mRNA, None) , ( protein: GAM, None) , ( protein: L227, None) " }

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{ "id": "2325", "sentence": "The inhibition of B104 cell growth induced by anti-MHC class II Ab was Ca(2+) -independent and not inhibited by actinomycin D or cyclosporin A , and cell cycle arrest at the G2/M interphase was not observed.", "label": " ( cell line: B104 cell, None) , ( protein: anti-MHC class II Ab, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: B104 cell, None) , ( protein: anti-MHC class II Ab, None) " }

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{ "id": "2326", "sentence": "These features are very different from those observed in B104 cell death induced by anti-IgM Ab .", "label": " ( protein: anti-IgM Ab, None) , ( cell line: B104 cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti-IgM Ab, None) , ( cell line: B104 cell, None) " }

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{ "id": "2327", "sentence": "Neither DNA fragmentation nor the morphology of apoptosis was observed.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2328", "sentence": "These findings demonstrate that cross-linking of MHC class II molecules transduced the negative signals through intracellular mechanisms different from those present in the cross-linking of surface IgM .", "label": " ( protein: IgM, None) , ( protein: MHC class II molecules, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IgM, None) , ( protein: MHC class II molecules, None) " }

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{ "id": "2329", "sentence": "Functional block for 1 alpha,25-dihydroxyvitamin D3 -mediated gene regulation in human B lymphocytes .", "label": " ( cell type: human B lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: human B lymphocytes, None) " }

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{ "id": "2330", "sentence": "Elements necessary for the steroid hormone 1 alpha,25-dihydroxyvitamin D3 ( 1 alpha,25-(OH)2D3 ) to induce a biological response include the presence of specific intracellular receptors ( vitamin D3 receptors ( VDR )) and modulation of gene expression via hormone-activated receptor binding to regulatory regions of target genes .", "label": " ( protein: VDR, None) , ( protein: vitamin D3 receptors, None) , ( protein: regulatory regions, None) , ( protein: intracellular receptors, None) , ( DNA: target genes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: VDR, None) , ( protein: vitamin D3 receptors, None) , ( protein: regulatory regions, None) , ( protein: intracellular receptors, None) , ( DNA: target genes, None) " }

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{ "id": "2331", "sentence": "These parameters were examined in normal and Epstein-Barr virus-immortalized human B cells and compared with 1 alpha,25-(OH)2D3 -responsive cells of the T and monocytic lineages .", "label": " ( cell line: Epstein-Barr virus-immortalized human B cells, None) , ( cell line: 1 alpha,25-(OH)2D3 -responsive cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: Epstein-Barr virus-immortalized human B cells, None) , ( cell line: 1 alpha,25-(OH)2D3 -responsive cells, None) " }

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{ "id": "2332", "sentence": "Although resting tonsillar B cells did not express VDR mRNA , activation of these cells with interleukin-4 induced VDR in the absence of exogenously supplemented 1 alpha,25-(OH)2D3 .", "label": " ( RNA: VDR mRNA, None) , ( protein: VDR, None) , ( protein: interleukin-4, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: VDR mRNA, None) , ( protein: VDR, None) , ( protein: interleukin-4, None) " }

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{ "id": "2333", "sentence": "As indicators of hormone-mediated gene regulation we analyzed modulation of CD23 , a common B cell/monocyte surface antigen , and 24-hydroxylase .", "label": " ( protein: common B cell/monocyte surface antigen, None) , ( protein: 24-hydroxylase, None) , ( protein: CD23, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: common B cell/monocyte surface antigen, None) , ( protein: 24-hydroxylase, None) , ( protein: CD23, None) " }

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{ "id": "2334", "sentence": "1 alpha,25-(OH)2D3 inhibited CD23 expression in U937 cells , yet failed to modulate CD23 expression in B cells .", "label": " ( protein: CD23, None) , ( cell line: U937 cells, None) , ( cell type: B cells, None) , ( protein: CD23, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD23, None) , ( cell line: U937 cells, None) , ( cell type: B cells, None) , ( protein: CD23, None) " }

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{ "id": "2335", "sentence": "Furthermore, 1 alpha,25-(OH)2D3 induced 24-hydroxylase mRNA expression and metabolic activity in both U937 cells and lectin-activated T cells , yet failed to induce 24-hydroxylase mRNA or its metabolic activity in B cells .", "label": " ( RNA: 24-hydroxylase mRNA, None) , ( cell type: lectin-activated T cells, None) , ( cell line: U937 cells, None) , ( cell type: B cells, None) , ( protein: 24-hydroxylase, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: 24-hydroxylase mRNA, None) , ( cell type: lectin-activated T cells, None) , ( cell line: U937 cells, None) , ( cell type: B cells, None) , ( protein: 24-hydroxylase, None) " }

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{ "id": "2336", "sentence": "These findings suggest that although human B lymphocytes can express VDR mRNA and protein , they exhibit a functional block for vitamin D -dependent gene regulation .", "label": " ( RNA: VDR mRNA, None) , ( protein: protein, None) , ( cell type: human B lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( RNA: VDR mRNA, None) , ( protein: protein, None) , ( cell type: human B lymphocytes, None) " }

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{ "id": "2337", "sentence": "Positive and negative regulation of IL-2 gene expression : role of multiple regulatory sites.", "label": " ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) " }

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{ "id": "2338", "sentence": "Interleukin 2 ( IL-2 ) is an important lymphokine required in the process of T cell activation , proliferation , clonal expansion and differentiation .", "label": " ( protein: IL-2, None) , ( protein: Interleukin 2, None) , ( protein: lymphokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( protein: Interleukin 2, None) , ( protein: lymphokine, None) " }

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{ "id": "2339", "sentence": "The IL-2 gene displays both T cell specific and inducible expression: it is only expressed in CD4+ T cells after antigenic or mitogenic stimulation .", "label": " ( DNA: IL-2 gene, None) , ( cell type: CD4+ T cells, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: IL-2 gene, None) , ( cell type: CD4+ T cells, None) , ( protein: IL-2, None) " }

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{ "id": "2340", "sentence": "Several cis-acting regulatory sites are required for induction of the IL-2 gene after stimulation.", "label": " ( DNA: cis-acting regulatory sites, None) , ( DNA: IL-2 gene, None) , ( protein: IL-2, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: cis-acting regulatory sites, None) , ( DNA: IL-2 gene, None) , ( protein: IL-2, None) " }

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{ "id": "2341", "sentence": "In this study, we have analysed the function of these cis-acting regulatory sites in the context of the native IL-2 enhancer and promoter sequence .", "label": " ( DNA: promoter sequence, None) , ( DNA: cis-acting regulatory sites, None) , ( protein: IL-2, None) , ( DNA: IL-2 enhancer, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: promoter sequence, None) , ( DNA: cis-acting regulatory sites, None) , ( protein: IL-2, None) , ( DNA: IL-2 enhancer, None) " }

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{ "id": "2342", "sentence": "The results of this study suggest that the NFAT ( -276 to -261 ), the distal octamer ( -256 to -248 ) and the proximal octamer ( -75 to -66 ) sites not only act as enhancers of IL-2 gene transcription in the presence of cellular stimulation , but also have a silencing effect on IL-2 gene expression in resting cells.", "label": " ( protein: IL-2, None) , ( DNA: -276 to -261, None) , ( DNA: IL-2 gene, None) , ( DNA: distal octamer, None) , ( DNA: proximal octamer, None) , ( DNA: -256 to -248, None) , ( DNA: IL-2 gene, None) , ( DNA: -75 to -66, None) , ( protein: IL-2, None) , ( protein: NFAT, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-2, None) , ( DNA: -276 to -261, None) , ( DNA: IL-2 gene, None) , ( DNA: distal octamer, None) , ( DNA: proximal octamer, None) , ( DNA: -256 to -248, None) , ( DNA: IL-2 gene, None) , ( DNA: -75 to -66, None) , ( protein: IL-2, None) , ( protein: NFAT, None) " }

[]

{ "id": "2343", "sentence": "Two other sites display disparate effects on IL-2 gene expression in different T leukemia cell lines : the distal purine box ( -291 to -277 ) and the proximal purine box sites ( -145 to -128 ).", "label": " ( cell line: T leukemia cell lines, None) , ( DNA: proximal purine box sites, None) , ( protein: IL-2, None) , ( DNA: distal purine box, None) , ( DNA: -291 to -277, None) , ( DNA: IL-2 gene, None) , ( DNA: -145 to -128, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: T leukemia cell lines, None) , ( DNA: proximal purine box sites, None) , ( protein: IL-2, None) , ( DNA: distal purine box, None) , ( DNA: -291 to -277, None) , ( DNA: IL-2 gene, None) , ( DNA: -145 to -128, None) " }

[]

{ "id": "2344", "sentence": "Finally, the AP-1 (-186 to -176) and the kappa B sites ( -206 to -195 ) respond to different cellular activation in EL4 cells .", "label": " ( cell line: EL4 cells, None) , ( DNA: -206 to -195, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: EL4 cells, None) , ( DNA: -206 to -195, None) " }

[]

{ "id": "2345", "sentence": "The AP-1 site mediated the response to PMA stimulation while the kappa B site responded to IL-1 stimulation .", "label": " ( protein: IL-1, None) , ( DNA: AP-1 site, None) , ( DNA: kappa B site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-1, None) , ( DNA: AP-1 site, None) , ( DNA: kappa B site, None) " }

[]

{ "id": "2346", "sentence": "These data suggest that the regulation of IL-2 gene expression is a complex process and multiple cis-acting regulatory sites interact to exert different effects in T cells representative of alternative stages of differentiation .", "label": " ( DNA: cis-acting regulatory sites, None) , ( protein: IL-2, None) , ( DNA: IL-2 gene, None) , ( cell type: T cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: cis-acting regulatory sites, None) , ( protein: IL-2, None) , ( DNA: IL-2 gene, None) , ( cell type: T cells, None) " }

[]

{ "id": "2347", "sentence": "Sp1 is a critical factor for the monocytic specific expression of human CD14 .", "label": " ( protein: human CD14, None) , ( protein: Sp1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: human CD14, None) , ( protein: Sp1, None) " }

[]

{ "id": "2348", "sentence": "CD14 is a membrane glycoprotein expressed specifically on monocytes and macrophages , and its expression is markedly increased during the process of monocyte differentiation .", "label": " ( protein: CD14, None) , ( cell type: macrophages, None) , ( protein: membrane glycoprotein, None) , ( cell type: monocytes, None) , ( cell type: monocyte, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD14, None) , ( cell type: macrophages, None) , ( protein: membrane glycoprotein, None) , ( cell type: monocytes, None) , ( cell type: monocyte, None) " }

[]

{ "id": "2349", "sentence": "In order to study CD14 gene regulation , the human CD14 gene was cloned from a partial EcoRI digested chromosome 5 library .", "label": " ( protein: CD14, None) , ( protein: EcoRI, None) , ( DNA: chromosome 5, None) , ( DNA: EcoRI digested chromosome 5 library, None) , ( protein: CD14, None) , ( protein: human CD14, None) , ( DNA: CD14 gene, None) , ( DNA: human CD14 gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD14, None) , ( protein: EcoRI, None) , ( DNA: chromosome 5, None) , ( DNA: EcoRI digested chromosome 5 library, None) , ( protein: CD14, None) , ( protein: human CD14, None) , ( DNA: CD14 gene, None) , ( DNA: human CD14 gene, None) " }

[]

{ "id": "2350", "sentence": "A 5.5-kilobase genomic clone contained the full-length CD14 coding sequence and 4.2 kilobases of 5'-upstream sequence .", "label": " ( DNA: CD14 coding sequence, None) , ( protein: CD14, None) , ( DNA: 4.2 kilobases of 5#$%#-upstream sequence, None) , ( DNA: 5.5-kilobase genomic clone, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: CD14 coding sequence, None) , ( protein: CD14, None) , ( DNA: 4.2 kilobases of 5#$%#-upstream sequence, None) , ( DNA: 5.5-kilobase genomic clone, None) " }

[]

{ "id": "2351", "sentence": "One major and one minor transcription start site were identified 101 and 130 base pairs (bp) upstream , respectively, from the protein translation start ATG .", "label": " ( DNA: 101 and 130 base pairs (bp) upstream, None) , ( DNA: protein translation start ATG, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: 101 and 130 base pairs (bp) upstream, None) , ( DNA: protein translation start ATG, None) " }

[]

{ "id": "2352", "sentence": "A DNA fragment containing 128 bp of upstream sequence had strong, monocyte-specific promoter activity in the CD14 positive monocytic cell line Mono Mac 6 as compared to the nonmonocytic cell lines HeLa and REX .", "label": " ( cell line: CD14 positive monocytic cell line, None) , ( DNA: DNA fragment, None) , ( protein: CD14, None) , ( DNA: 128 bp of upstream sequence, None) , ( cell line: Mono Mac 6, None) , ( cell line: nonmonocytic cell lines, None) , ( cell line: REX, None) , ( cell line: HeLa, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell line: CD14 positive monocytic cell line, None) , ( DNA: DNA fragment, None) , ( protein: CD14, None) , ( DNA: 128 bp of upstream sequence, None) , ( cell line: Mono Mac 6, None) , ( cell line: nonmonocytic cell lines, None) , ( cell line: REX, None) , ( cell line: HeLa, None) " }

[]

{ "id": "2353", "sentence": "Four regions in this DNA fragment interact with nuclear proteins isolated from monocytic cells .", "label": " ( DNA: DNA fragment, None) , ( protein: nuclear proteins, None) , ( cell type: monocytic cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: DNA fragment, None) , ( protein: nuclear proteins, None) , ( cell type: monocytic cells, None) " }

[]

{ "id": "2354", "sentence": "The Sp1 transcription factor bound to three different regions in the CD14 promoter .", "label": " ( protein: CD14, None) , ( protein: transcription factor, None) , ( protein: Sp1, None) , ( DNA: CD14 promoter, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD14, None) , ( protein: transcription factor, None) , ( protein: Sp1, None) , ( DNA: CD14 promoter, None) " }

[]

{ "id": "2355", "sentence": "Mutation of the major Sp1 binding site ( -110 bp ) decreased tissue-specific promoter activity, and these results, together with transactivation experiments , demonstrate that Sp1 plays a critical role in the tissue-specific expression of CD14 in monocytic cells .", "label": " ( protein: CD14, None) , ( protein: Sp1, None) , ( protein: Sp1, None) , ( DNA: -110 bp, None) , ( DNA: major Sp1 binding site, None) , ( cell type: monocytic cells, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: CD14, None) , ( protein: Sp1, None) , ( protein: Sp1, None) , ( DNA: -110 bp, None) , ( DNA: major Sp1 binding site, None) , ( cell type: monocytic cells, None) " }

[]

{ "id": "2356", "sentence": "CD14 Sp1 site oligonucleotides bound preferentially to a 105-kDa Sp1 species , which is present in higher relative levels in monocytic than non-monocytic cells , suggesting that modification of Sp1 , such as phosphorylation, may explain how the Sp1 site mediates monocytic specific promoter activity .", "label": " ( protein: 105-kDa Sp1 species, None) , ( protein: Sp1, None) , ( cell type: non-monocytic cells, None) , ( protein: Sp1, None) , ( cell type: monocytic, None) , ( protein: Sp1, None) , ( protein: CD14, None) , ( protein: Sp1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: 105-kDa Sp1 species, None) , ( protein: Sp1, None) , ( cell type: non-monocytic cells, None) , ( protein: Sp1, None) , ( cell type: monocytic, None) , ( protein: Sp1, None) , ( protein: CD14, None) , ( protein: Sp1, None) " }

[]

{ "id": "2357", "sentence": "The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2358", "sentence": "FK506 , an immunosuppressant , inhibits the production of several cytokines in T lymphocytes .", "label": " ( cell type: T lymphocytes, None) , ( protein: cytokines, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T lymphocytes, None) , ( protein: cytokines, None) " }

[]

{ "id": "2359", "sentence": "We observed that FK506 suppressed the transcription of a chemotactic cytokine , interleukin-8 ( IL-8 ) in a human T cell line , Jurkat cells , activated by phorbol 12-myristate 13-acetate ( PMA ) and calcium ( Ca2+ ) ionophore ( ionomycin ).", "label": " ( protein: IL-8, None) , ( protein: chemotactic cytokine, None) , ( cell line: human T cell line, None) , ( cell line: Jurkat cells, None) , ( protein: interleukin-8, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-8, None) , ( protein: chemotactic cytokine, None) , ( cell line: human T cell line, None) , ( cell line: Jurkat cells, None) , ( protein: interleukin-8, None) " }

[]

{ "id": "2360", "sentence": "By deleted and mutated analysis of the IL-8 promoters , the AP-1 and kappa B-like sites were identified as the responsive elements for PMA and ionomycin .", "label": " ( protein: IL-8, None) , ( DNA: kappa B-like sites, None) , ( DNA: IL-8 promoters, None) , ( DNA: AP-1 and kappa B-like sites, None) , ( DNA: AP-1, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-8, None) , ( DNA: kappa B-like sites, None) , ( DNA: IL-8 promoters, None) , ( DNA: AP-1 and kappa B-like sites, None) , ( DNA: AP-1, None) " }

[]

{ "id": "2361", "sentence": "FK506 suppressed the transcriptions through the AP-1 or kappa B-like sites induced by PMA plus Ca(2+)-mobilizing agents, but not those induced by Ca(2+)-independent stimuli.", "label": " ( DNA: AP-1, None) , ( DNA: kappa B-like sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: AP-1, None) , ( DNA: kappa B-like sites, None) " }

[]

{ "id": "2362", "sentence": "In gel retardation analysis, FK506 had little effect on the binding to the AP-1 site of PMA / ionomycin -induced nuclear factors, which were recognized with anti-JunD or c-Fos antibody .", "label": " ( protein: c-Fos antibody, None) , ( protein: anti-JunD, None) , ( DNA: AP-1 site, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: c-Fos antibody, None) , ( protein: anti-JunD, None) , ( DNA: AP-1 site, None) " }

[]

{ "id": "2363", "sentence": "In contrast, FK506 or EGTA ( Ca2+ chelator ) similarly affected the formation of kappa B-like site binding complexes , which were not recognized by any antibodies against the human Rel family proteins ( c-Rel , p65 , p50 , and p49 ).", "label": " ( protein: human Rel family proteins, None) , ( protein: kappa B-like site binding complexes, None) , ( protein: p65, None) , ( protein: c-Rel, None) , ( protein: antibodies, None) , ( protein: p50, None) , ( protein: p49, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: human Rel family proteins, None) , ( protein: kappa B-like site binding complexes, None) , ( protein: p65, None) , ( protein: c-Rel, None) , ( protein: antibodies, None) , ( protein: p50, None) , ( protein: p49, None) " }

[]

{ "id": "2364", "sentence": "Furthermore, we confirmed the previous report that FK506 suppressed the PMA / ionomycin -induced activation through authentic kappa B site of immunoglobulin (Ig) gene , to which NF-kappa B binding was also decreased by FK506 , indicating that both IL-8 kappa B-like site and Ig kappa B site are FK506 -sensitive in spite of the difference of binding factors .", "label": " ( DNA: kappa B site, None) , ( DNA: kappa B site, None) , ( protein: NF-kappa B, None) , ( DNA: IL-8 kappa B-like site, None) , ( protein: IL-8, None) , ( protein: binding factors, None) , ( DNA: immunoglobulin (Ig) gene, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: kappa B site, None) , ( DNA: kappa B site, None) , ( protein: NF-kappa B, None) , ( DNA: IL-8 kappa B-like site, None) , ( protein: IL-8, None) , ( protein: binding factors, None) , ( DNA: immunoglobulin (Ig) gene, None) " }

[]

{ "id": "2365", "sentence": "Our results indicate that not only the reported IL-2 NF-AT and NFIL-2A sites and Ig kappa B site , but also the IL-8 AP-1 and kappa B-like sites are terminals of FK506 -sensitive pathway involving Ca2+ mobilization .", "label": " ( DNA: kappa B site, None) , ( DNA: AP-1, None) , ( protein: IL-8, None) , ( DNA: kappa B-like sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: kappa B site, None) , ( DNA: AP-1, None) , ( protein: IL-8, None) , ( DNA: kappa B-like sites, None) " }

[]

{ "id": "2366", "sentence": "Androgen binding sites in peripheral human mononuclear leukocytes of healthy males and females .", "label": " ( cell type: peripheral human mononuclear leukocytes, None) , ( protein: Androgen binding sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral human mononuclear leukocytes, None) , ( protein: Androgen binding sites, None) " }

[]

{ "id": "2367", "sentence": "Androgen binding sites have been identified in circulating human mononuclear leukocytes of healthy donors of both sexes.", "label": " ( cell type: circulating human mononuclear leukocytes, None) , ( protein: Androgen binding sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: circulating human mononuclear leukocytes, None) , ( protein: Androgen binding sites, None) " }

[]

{ "id": "2368", "sentence": "Cells were separated from blood samples on a Ficoll gradient and incubated with different concentrations of [3H]testosterone in the presence or absence of a 400-fold excess of unlabelled testosterone .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2369", "sentence": "Binding data were derived from Scatchard analysis .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2370", "sentence": "The binding sites fulfil the required criteria for specific steroid binding sites however differ somewhat from the classic androgen receptors from genital skin fibroblast : in fertile adult males (n = 20) the binding sites showed (1) a high affinity for testosterone (1.32 +/- 0.49 nM; mean +/- SD), (2) a saturable capacity (184 +/- 52 binding sites per cell; mean +/- SD), and (3) a characteristic competitive binding profile for other steroid hormones (relative binding affinities: testosterone = dihydrotestosterone > 17 beta-estradiol > progesterone , whereas aldosterone, 17-hydroxy-progesterone and cortisol did not compete appreciably).", "label": " ( protein: binding sites, None) , ( protein: steroid binding sites, None) , ( protein: binding sites, None) , ( cell type: genital skin fibroblast, None) , ( protein: binding sites, None) , ( protein: androgen receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: binding sites, None) , ( protein: steroid binding sites, None) , ( protein: binding sites, None) , ( cell type: genital skin fibroblast, None) , ( protein: binding sites, None) , ( protein: androgen receptors, None) " }

[]

{ "id": "2371", "sentence": "Furthermore the number of binding sites determined using [3H]dihydrotestosterone , [3H]RU-1881 , or [3H] testosterone were comparable.", "label": " ( protein: binding sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: binding sites, None) " }

[]

{ "id": "2372", "sentence": "This raises the possibility that androgen receptors in peripheral mononuclear leukocytes differ from those in genital skin fibroblasts .", "label": " ( cell type: peripheral mononuclear leukocytes, None) , ( cell type: genital skin fibroblasts, None) , ( protein: androgen receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral mononuclear leukocytes, None) , ( cell type: genital skin fibroblasts, None) , ( protein: androgen receptors, None) " }

[]

{ "id": "2373", "sentence": "There was no apparent correlation between serum testosterone concentrations and androgen binding sites .", "label": " ( protein: androgen binding sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: androgen binding sites, None) " }

[]

{ "id": "2374", "sentence": "In fertile women remarkable changes in androgen binding sites were seen in the course of the menstrual cycle , with a significant increase in the immediate preovulatory period .", "label": " ( protein: androgen binding sites, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: androgen binding sites, None) " }

[]

{ "id": "2375", "sentence": "The presence of androgen receptors in peripheral mononuclear leukocytes provides for the first time the experimental basis for an hypothesis of direct, receptor-mediated effects of androgens on mature immunocompetent cells .", "label": " ( cell type: peripheral mononuclear leukocytes, None) , ( cell type: mature immunocompetent cells, None) , ( protein: androgen receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: peripheral mononuclear leukocytes, None) , ( cell type: mature immunocompetent cells, None) , ( protein: androgen receptors, None) " }

[]

{ "id": "2376", "sentence": "The immunological implications of these results are discussed.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

[]

{ "id": "2377", "sentence": "Induction of IL-8 expression in T cells uses the CD28 costimulatory pathway .", "label": " ( cell type: T cells, None) , ( protein: CD28, None) , ( protein: IL-8, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: T cells, None) , ( protein: CD28, None) , ( protein: IL-8, None) " }

[]

{ "id": "2378", "sentence": "IL-8 , a potent chemotactic factor for neutrophil granulocytes and lymphocytes , is a proinflammatory cytokine secreted by a variety of cell types, including T cells .", "label": " ( protein: IL-8, None) , ( cell type: neutrophil granulocytes, None) , ( cell type: lymphocytes, None) , ( cell type: T cells, None) , ( protein: chemotactic factor, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: IL-8, None) , ( cell type: neutrophil granulocytes, None) , ( cell type: lymphocytes, None) , ( cell type: T cells, None) , ( protein: chemotactic factor, None) " }

[]

{ "id": "2379", "sentence": "Stimulation of the CD28 cell surface molecule delivers costimulatory signals essential for lymphokine production in activated T cells via a conserved sequence element found in the promoter of several lymphokine genes .", "label": " ( protein: lymphokine, None) , ( protein: CD28 cell surface molecule, None) , ( protein: CD28, None) , ( protein: lymphokine, None) , ( DNA: lymphokine genes, None) , ( cell type: activated T cells, None) , ( DNA: promoter, None) , ( DNA: conserved sequence element, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: lymphokine, None) , ( protein: CD28 cell surface molecule, None) , ( protein: CD28, None) , ( protein: lymphokine, None) , ( DNA: lymphokine genes, None) , ( cell type: activated T cells, None) , ( DNA: promoter, None) , ( DNA: conserved sequence element, None) " }

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{ "id": "2380", "sentence": "Anti- CD28 -stimulated T cells produced significant amounts of IL-8 ; additionally, costimulation with anti-CD3 and anti- CD28 Abs resulted in a synergistic induction of IL-8 secretion .", "label": " ( protein: anti- CD28 Abs, None) , ( protein: CD28, None) , ( protein: anti-CD3, None) , ( cell line: Anti- CD28 -stimulated T cells, None) , ( protein: CD28, None) , ( protein: IL-8, None) , ( protein: IL-8, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti- CD28 Abs, None) , ( protein: CD28, None) , ( protein: anti-CD3, None) , ( cell line: Anti- CD28 -stimulated T cells, None) , ( protein: CD28, None) , ( protein: IL-8, None) , ( protein: IL-8, None) " }

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{ "id": "2381", "sentence": "Sequence homology, single nucleotide mutations , and anti- CD28 Ab stimulation studies established that the NF-kappa B -like sequence in the promoter of the IL-8 gene functioned as a CD28 response element .", "label": " ( DNA: CD28 response element, None) , ( DNA: IL-8 gene, None) , ( protein: IL-8, None) , ( protein: CD28, None) , ( protein: CD28, None) , ( DNA: promoter, None) , ( DNA: NF-kappa B -like sequence, None) , ( protein: NF-kappa B, None) , ( protein: anti- CD28 Ab, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: CD28 response element, None) , ( DNA: IL-8 gene, None) , ( protein: IL-8, None) , ( protein: CD28, None) , ( protein: CD28, None) , ( DNA: promoter, None) , ( DNA: NF-kappa B -like sequence, None) , ( protein: NF-kappa B, None) , ( protein: anti- CD28 Ab, None) " }

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{ "id": "2382", "sentence": "Furthermore, cyclosporin A , but not rapamycin , blocked the synergistic induction of IL-8 expression achieved with anti-CD3 and anti- CD28 costimulation .", "label": " ( protein: anti-CD3, None) , ( protein: CD28, None) , ( protein: IL-8, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: anti-CD3, None) , ( protein: CD28, None) , ( protein: IL-8, None) " }

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{ "id": "2383", "sentence": "The involvement of a CD28 response element in the induction of IL-8 expression in activated T cells may provide new insights into the pathogenesis and persistence of immune disorders characterized by increased levels of IL-8 , such as psoriasis and rheumatoid arthritis .", "label": " ( DNA: CD28 response element, None) , ( protein: IL-8, None) , ( protein: CD28, None) , ( cell type: activated T cells, None) , ( protein: IL-8, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( DNA: CD28 response element, None) , ( protein: IL-8, None) , ( protein: CD28, None) , ( cell type: activated T cells, None) , ( protein: IL-8, None) " }

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{ "id": "2384", "sentence": "MHC class II signaling in B-cell activation [see comments]", "label": " ( protein: MHC class II, None) , ( cell type: B-cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MHC class II, None) , ( cell type: B-cell, None) " }

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{ "id": "2385", "sentence": "The cognate interaction between T cells and antigen-presenting cells ( APCs ), mediated by major histocompatibility complex (MHC) class II molecules , results in the delivery of activation signals to the APC .", "label": " ( cell type: antigen-presenting cells, None) , ( cell type: APCs, None) , ( cell type: T cells, None) , ( protein: major histocompatibility complex (MHC) class II molecules, None) , ( cell type: APC, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: antigen-presenting cells, None) , ( cell type: APCs, None) , ( cell type: T cells, None) , ( protein: major histocompatibility complex (MHC) class II molecules, None) , ( cell type: APC, None) " }

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{ "id": "2386", "sentence": "These signals contribute to the expression of co-stimulatory activity by APCs and have important consequences for cell effector function .", "label": " ( cell type: APCs, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: APCs, None) " }

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{ "id": "2387", "sentence": "MHC class II molecules also serve as receptors for B-cell stimulation by microbial superantigens .", "label": " ( protein: microbial superantigens, None) , ( cell type: B-cell, None) , ( protein: MHC class II, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: microbial superantigens, None) , ( cell type: B-cell, None) , ( protein: MHC class II, None) " }

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{ "id": "2388", "sentence": "In this review, Paul Scholl and Raif Geha discuss recent advances in our understanding of mechanisms of MHC class II signaling and analyse their role in human B-cell activation .", "label": " ( protein: MHC class II, None) , ( cell type: B-cell, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: MHC class II, None) , ( cell type: B-cell, None) " }

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{ "id": "2389", "sentence": "Effects of glucocorticoids in rheumatoid arthritis .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2390", "sentence": "Diminished glucocorticoid receptors do not result in glucocorticoid resistance .", "label": " ( protein: glucocorticoid receptors, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: glucocorticoid receptors, None) " }

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{ "id": "2391", "sentence": "OBJECTIVE.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2392", "sentence": "Lymphocytes of patients with rheumatoid arthritis ( RA ) have diminished receptor density; thus, patients with RA should show partial resistance to glucocorticoids .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2393", "sentence": "We investigated the glucocorticoid sensitivity of lymphocytes in RA patients compared with healthy subjects .", "label": " ( cell type: lymphocytes, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( cell type: lymphocytes, None) " }

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{ "id": "2394", "sentence": "METHODS.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2395", "sentence": "We determined the effects of glucocorticoids on lymphocyte proliferation and cytokine release .", "label": " ( protein: cytokine, None) , ( cell type: lymphocyte, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine, None) , ( cell type: lymphocyte, None) " }

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{ "id": "2396", "sentence": "RESULTS.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2397", "sentence": "Proliferation and cytokine release were inhibited in RA patients to the same extent as in healthy controls .", "label": " ( protein: cytokine, None) ", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " ( protein: cytokine, None) " }

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{ "id": "2398", "sentence": "CONCLUSION.", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }

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{ "id": "2399", "sentence": "Diminished receptor density in RA patients does not result in glucocorticoid resistance .", "label": " None", "instruction": "Locate the role in the text that participated in the event based on the event type and return it in the event list. \n Option: Event type: RNA,cell type,protein,cell line,DNA, Arguments type: . \nText: {0} \nAnswer:", "ground_truth": " None" }