ESM zero-shot variant prediction

this was inspired from this paper and adaptated from this repo

in the 'sequence' text box the protein full amino acid sequence that is to be analysed must be given, jolly charachters (e.g. -X.B) are supported (but at the moment the visualisation does not show the correct results)
there's three running modes that can be chosen, depending on the input in the 'substitution' box:
- if another sequence is given, the positions that are different between the two will be evaluated (NB the sequences must be of the same length) and their score returned
- if a list of integers is given, a deep mutational scan will be performed at those positions in the input sequence and the scores for the amino acids, different from the original one, will be returned
- if a single substitution or a list thereof is given (in the form of B008S), the single substitution score is returned
you can choose which ESM model to use for the calculations, these models are the ones that are available at runtime on Hugging Face Model Hub
there's 2 scoring strategies available: wt-marginals and masked marginals; the first one is faster, but less accurate, the second one considers the sequence context more thoroughly, but is sensibly slower (the run time scales linearly with sequence length)
the results will be shown in a table, with color coding and sorted by fitness (if performing a deep mutational scan)
the output data is available for download from the box at the bottom as a CSV file