{"text": "Phenotypic analysis demonstrates that trio and Abl cooperate in regulating axon outgrowth in the embryonic central nervous system ( CNS ) .", "entity": [{"entity": "trio", "entity_type": "GENE", "pos": [38, 42]}, {"entity": "Abl", "entity_type": "GENE", "pos": [47, 50]}], "task": "NER"}
{"text": "In the cervical enlargement they were located in the middle part of lamina VII and in lamina VIII , accounting for about 25 % of the total labeled neurons .", "entity": [], "task": "NER"}
{"text": "We measured electromyograms ( EMG ) of the alae nasi to determine the relationship between their activity and timing to contraction of the rib cage muscles and diaphragm during obstructive apnea in nine patients .", "entity": [], "task": "NER"}
{"text": "A case control study ( 1 : 2 ) of 182 pairs of Hepatitis A was carried out in Weng - ling Zhe - jiang during April 1988 .", "entity": [], "task": "NER"}
{"text": "In the absence of shock , sepsis , or other identifiable causes of lactic acidosis , the severe anemia ( hemoglobin 1 . 2 g / dl ) appeared to be the primary etiologic factor .", "entity": [{"entity": "hemoglobin", "entity_type": "GENE", "pos": [105, 115]}], "task": "NER"}
{"text": "However the precise function of DNA - PK in DNA double - strand break repair is not known .", "entity": [{"entity": "DNA - PK", "entity_type": "GENE", "pos": [32, 40]}], "task": "NER"}
{"text": "The COR biosynthetic gene cluster in P . syringae pv . glycinea PG4180 is encoded by a 32 - kb region which contains both the structural and regulatory genes needed for COR synthesis .", "entity": [{"entity": "COR", "entity_type": "GENE", "pos": [4, 7]}, {"entity": "COR", "entity_type": "GENE", "pos": [169, 172]}], "task": "NER"}
{"text": "Substitution of cholinergic drugs in the treatment of Alzheimer type dementia ( AD / SDAT ) has hitherto not been very successful .", "entity": [], "task": "NER"}
{"text": "FEurea was also measured during stable graft function , 7 - 14 days prior to allograft dysfunction .", "entity": [], "task": "NER"}
{"text": "The findings are discussed with reference to possible mechanisms by which parasite development might be controlled .", "entity": [], "task": "NER"}
{"text": "Interestingly , basal MAPK , but not Raf - 1 , activity was constitutively enhanced in Jak1 - deficient HeLa cells .", "entity": [{"entity": "MAPK", "entity_type": "GENE", "pos": [22, 26]}, {"entity": "Raf - 1", "entity_type": "GENE", "pos": [37, 44]}, {"entity": "Jak1", "entity_type": "GENE", "pos": [87, 91]}], "task": "NER"}
{"text": "On the other hand hypokalemia , induced by diuretics , may also be accompanied by a significant depletion of total body K , bringing about more general consequences .", "entity": [], "task": "NER"}
{"text": "We present here the complete primary structure of human gp330 , the human variant of the principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats .", "entity": [{"entity": "human gp330", "entity_type": "GENE", "pos": [50, 61]}], "task": "NER"}
{"text": "A series of deletion mutants was expressed transiently in two human hepatocytes , HepG2 and PLC .", "entity": [], "task": "NER"}
{"text": "Biol .", "entity": [], "task": "NER"}
{"text": "Copyright 2000 Academic Press .", "entity": [], "task": "NER"}
{"text": "No patient demonstrated a decrease in bone marrow fibrosis as determined by serial procollagen ( PC III ) serum level analysis .", "entity": [{"entity": "procollagen", "entity_type": "GENE", "pos": [83, 94]}, {"entity": "PC III", "entity_type": "GENE", "pos": [97, 103]}], "task": "NER"}
{"text": "In four calves given Haemonchus contortus larvae , the serum pepsinogen concentration rose quickly to reach a mean of 3 . 5 iu tyrosine on day 14 after infection .", "entity": [{"entity": "serum pepsinogen", "entity_type": "GENE", "pos": [55, 71]}], "task": "NER"}
{"text": "The P - ITIM - compelled multi - phosphoprotein complex binds to and activates SHP - 2 , which in turn dephosphorylates SHIP and Shc and probably other substrates .", "entity": [{"entity": "P - ITIM - compelled multi - phosphoprotein complex", "entity_type": "GENE", "pos": [4, 55]}, {"entity": "SHP - 2", "entity_type": "GENE", "pos": [79, 86]}, {"entity": "SHIP", "entity_type": "GENE", "pos": [120, 124]}, {"entity": "Shc", "entity_type": "GENE", "pos": [129, 132]}], "task": "NER"}
{"text": "Paradoxically , loop 3i from the M1Ach - muscarinic receptor also maximally inhibited GnRH agonist - stimulated cAMP accumulation and PRL release by 40 % ( both effects mediated through activation of the Gs protein ) .", "entity": [{"entity": "M1Ach - muscarinic receptor", "entity_type": "GENE", "pos": [33, 60]}, {"entity": "GnRH", "entity_type": "GENE", "pos": [86, 90]}, {"entity": "PRL", "entity_type": "GENE", "pos": [134, 137]}, {"entity": "Gs protein", "entity_type": "GENE", "pos": [204, 214]}], "task": "NER"}
{"text": "Electrophoretic mobility - shift assays with nuclear extracts from COS - 1 cells transfected with expression vectors for SMADs 1 - 5 indicate that SMAD3 forms a complex with a migration similar to that of the endogenous TGF - beta - specific complex observed in fibroblast extracts .", "entity": [{"entity": "SMADs 1 - 5", "entity_type": "GENE", "pos": [121, 132]}, {"entity": "SMAD3", "entity_type": "GENE", "pos": [147, 152]}, {"entity": "endogenous TGF - beta - specific complex", "entity_type": "GENE", "pos": [209, 249]}], "task": "NER"}
{"text": "Oligomers corresponding to the region of the mlc - 1 / 3 enhancer , which encompasses this conserved sequence , bound MEF - 2 and competed for its binding to the mck enhancer .", "entity": [{"entity": "mlc - 1 / 3 enhancer", "entity_type": "GENE", "pos": [45, 65]}, {"entity": "MEF - 2", "entity_type": "GENE", "pos": [118, 125]}, {"entity": "mck", "entity_type": "GENE", "pos": [162, 165]}], "task": "NER"}
{"text": "cDNA cloning and transcriptional properties of a novel GC box - binding protein , BTEB2 .", "entity": [{"entity": "GC box - binding protein", "entity_type": "GENE", "pos": [55, 79]}, {"entity": "BTEB2", "entity_type": "GENE", "pos": [82, 87]}], "task": "NER"}
{"text": "N0 disease is more favorable than N1 or N2 disease .", "entity": [], "task": "NER"}
{"text": "Elimination of brush border as well as of glomerular marker proteins was significantly lower after intravenous injection of low - osmolar CM iopamidol 370 ( 832 mOsm / kg ) than after meglumine diatrizoate 76 ( 2100 mOsm / kg ) .", "entity": [], "task": "NER"}
{"text": "Overall graft and patient survival after HAT were 33 . 3 % and 75 % , respectively .", "entity": [], "task": "NER"}
{"text": "Of 81 girls cured from the bacteriuria 24 recurred , 5 with a symptomatic pyelonephritis and 3 with cystitis .", "entity": [], "task": "NER"}
{"text": "Partial hepatectomy in metastatic Wilms ' tumor .", "entity": [], "task": "NER"}
{"text": "MRS allowed the differentiation of the following metabolites in 5 patients : N - acetyl - aspartate ( NAA ) , creatine and phosphocreatine , phosphorylcholine and glycerophosphorylcholine , beta - and gamma - glutamate ( GLU ) .", "entity": [], "task": "NER"}
{"text": "Plasma prolactin in patients with colorectal cancer .", "entity": [{"entity": "prolactin", "entity_type": "GENE", "pos": [7, 16]}], "task": "NER"}
{"text": "Studies of fetal maturity", "entity": [], "task": "NER"}
{"text": "A comparison of the rate of recovery and time for detection of mycobacteria from clinical specimens of the newly developed Mycobacteria Growth Indicator Tube ( MGIT ) , the biphasic Septi - Chek , and the egg - based Ogawa medium was made .", "entity": [], "task": "NER"}
{"text": "E2A - HLF - mediated cell transformation requires both the trans - activation domains of E2A and the leucine zipper dimerization domain of HLF .", "entity": [{"entity": "E2A", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "HLF", "entity_type": "GENE", "pos": [6, 9]}, {"entity": "E2A", "entity_type": "GENE", "pos": [89, 92]}, {"entity": "HLF", "entity_type": "GENE", "pos": [139, 142]}], "task": "NER"}
{"text": "In transient transfections using luciferase reporter genes driven by 1 kb of the 5 ' flanking DNA of the three CALM genes , the promoter activity correlated with the endogenous CALM transcriptional activity , but only when the 5 ' untranslated regions were included in the constructs .", "entity": [{"entity": "luciferase reporter genes", "entity_type": "GENE", "pos": [33, 58]}, {"entity": "CALM genes", "entity_type": "GENE", "pos": [111, 121]}, {"entity": "endogenous CALM", "entity_type": "GENE", "pos": [166, 181]}], "task": "NER"}
{"text": "In this report , several health behaviors were investigated in relation to maintaining mobility during 4 years of follow - up among 6 , 981 men and women aged 65 years and older with intact mobility at baseline between 1981 and 1983 who lived in one of three communities : East Boston , Massachusetts ; Iowa and Washington counties , Iowa ; and New Haven , Connecticut .", "entity": [], "task": "NER"}
{"text": "Binding of ZAP - 70 to phospho - TAMs is notable for the high level of cooperativity between the two SH2 domains , which individually demonstrate low affinity interaction with the ligand .", "entity": [{"entity": "ZAP - 70", "entity_type": "GENE", "pos": [11, 19]}, {"entity": "SH2 domains", "entity_type": "GENE", "pos": [101, 112]}], "task": "NER"}
{"text": "A clinical study .", "entity": [], "task": "NER"}
{"text": "Two - dimensional echocardiographic parasternal long - and short - axis views were obtained during graded bleeding by rapid withdrawal of blood from an arterial cannula , with increments of 5 % each up to 30 % of calculated blood volume .", "entity": [], "task": "NER"}
{"text": "Comparative analyses indicate that the 5 ' - peripheral domain exhibits a 75 - bp length polymorphism near sequences associated with the termination of the H - strand replication .", "entity": [], "task": "NER"}
{"text": "Thirty - five pts were transplanted for constitutional disease : Fanconi anemia ( FA ) ( 26 pts ) , Dyskeratosis congenita ( 2 pts ) , Blackfan - Diamond erythroblastopenia ( 2 pts ) , Glanzmann thrombasthenia ( 1 pt ) , osteopetrosis ( 1 pt ) and Gaucher ' s disease ( 1 pt ) .", "entity": [], "task": "NER"}
{"text": "One patient exhibited a non - sense mutation ( codon 388 ) , which changed a glutamine codon ( CAG ) to a stop codon ( TAG ) .", "entity": [], "task": "NER"}
{"text": "Using the same approach we have shown that hFIRE binds the stimulatory proteins Sp1 and Sp3 in addition to CBF .", "entity": [{"entity": "hFIRE", "entity_type": "GENE", "pos": [43, 48]}, {"entity": "Sp1", "entity_type": "GENE", "pos": [80, 83]}, {"entity": "Sp3", "entity_type": "GENE", "pos": [88, 91]}, {"entity": "CBF", "entity_type": "GENE", "pos": [107, 110]}], "task": "NER"}
{"text": "Cellular fractionation and Percoll gradient centrifugation combined with immunoblotting show that p67 cofractionates with nuclei and is enriched in resistant structure that is insoluble in 2 M NaCl , 25 mM lithium 3 , 5 ' - diiodosalicylate , and 1 % Triton but is soluble in 8 M urea .", "entity": [{"entity": "p67", "entity_type": "GENE", "pos": [98, 101]}], "task": "NER"}
{"text": "Gene expression is in part controlled by chromatin remodeling factors and the acetylation state of nucleosomal histones .", "entity": [{"entity": "nucleosomal histones", "entity_type": "GENE", "pos": [99, 119]}], "task": "NER"}
{"text": "Corticosteroid treatment before , during , or after fludarabine treatment in patients with alkylator - resistant , low - grade lymphoid malignancies who have not received PCP prophylaxis is associated with an increased risk of opportunistic pulmonary infections .", "entity": [], "task": "NER"}
{"text": "Here we demonstrate that several genes associated with NHEJ perform essential functions in the repair of endonuclease - induced DSBs in vivo .", "entity": [], "task": "NER"}
{"text": "The primary structure of cholesterol esterase displayed no significant homology with other lipases , although the putative lipid interfacial recognition site of G - X - S - X - G is present in the cholesterol esterase sequence .", "entity": [{"entity": "cholesterol esterase", "entity_type": "GENE", "pos": [25, 45]}, {"entity": "lipases", "entity_type": "GENE", "pos": [91, 98]}, {"entity": "cholesterol esterase sequence", "entity_type": "GENE", "pos": [197, 226]}], "task": "NER"}
{"text": "Subtype - and response element - dependent differences in transactivation by peroxisome proliferator - activated receptors alpha and gamma .", "entity": [{"entity": "peroxisome proliferator - activated receptors alpha and gamma", "entity_type": "GENE", "pos": [77, 138]}], "task": "NER"}
{"text": "Monoclonal antibodies to the hapten phenyloxazolone were raised 7 days after immunization in mice of six strains ( BALB / c , C57BL - Igha , DBA2 , RF , A / J , and CE ) .", "entity": [], "task": "NER"}
{"text": "PMA produced similar results , but the induction of the WT AP1 c - jun promoter - CAT plasmid was smaller .", "entity": [{"entity": "WT AP1", "entity_type": "GENE", "pos": [56, 62]}, {"entity": "c - jun", "entity_type": "GENE", "pos": [63, 70]}], "task": "NER"}
{"text": "Although the QT duration was higher ( p = 0 . 0001 ) at night , the beat - to - beat variability of this interval was lower : in the time domain ( decreased standard deviation , p = 0 . 0005 ) , in the frequency domain ( decreased low - frequency power of the spectra , p = 0 . 004 ) , and the chaotic domain ( tighter clustering of the points in the Poincare plots ) .", "entity": [], "task": "NER"}
{"text": "J .", "entity": [], "task": "NER"}
{"text": "Student health", "entity": [], "task": "NER"}
{"text": "In both study stages . post - exposure treatment consisted of five injections of vaccine [ ( D ) ays 0 , 3 , 7 , 14 , 28 ] , together with a dose of rabies immunoglobulin ( RIG ) of equine or human origin on D0 .", "entity": [{"entity": "rabies immunoglobulin", "entity_type": "GENE", "pos": [149, 170]}, {"entity": "RIG", "entity_type": "GENE", "pos": [173, 176]}], "task": "NER"}
{"text": "Essential fatty acid deficiency in childhood", "entity": [], "task": "NER"}
{"text": "We have earlier proposed that CG rich sequences resembling CpG islands , which are associated with many imprinted genes and often subject to parental - specific methylation , could act as a common imprinting element .", "entity": [], "task": "NER"}
{"text": "Electrophoretic mobility - shift assays showed a rapid induction of nuclear proteins that bound to the consensus kappa B motif .", "entity": [{"entity": "consensus kappa B motif", "entity_type": "GENE", "pos": [103, 126]}], "task": "NER"}
{"text": "The thalamic SD was regularly triggered by short ( 0 . 02 - 0 . 05 s ) high - frequency ( 200 - 500 Hz ) ES of the parietal cortical surface .", "entity": [], "task": "NER"}
{"text": "As in IncP alpha plasmids , these operons are transcribed from a bidirectional promoter region consisting of trfAp for the trfA operon and trbAp and trbBp for the trb operon .", "entity": [{"entity": "trfAp", "entity_type": "GENE", "pos": [109, 114]}, {"entity": "trfA operon", "entity_type": "GENE", "pos": [123, 134]}, {"entity": "trbAp", "entity_type": "GENE", "pos": [139, 144]}, {"entity": "trbBp", "entity_type": "GENE", "pos": [149, 154]}, {"entity": "trb operon", "entity_type": "GENE", "pos": [163, 173]}], "task": "NER"}
{"text": "Comparison of the encoded ERCC3Dm protein with the homologous proteins of mouse and man shows a strong amino acid conservation ( 71 % identity ) , especially in the postulated DNA binding region and seven ' helicase ' domains .", "entity": [{"entity": "ERCC3Dm protein", "entity_type": "GENE", "pos": [26, 41]}, {"entity": "' helicase ' domains", "entity_type": "GENE", "pos": [205, 225]}], "task": "NER"}
{"text": "Genetic analysis places CWH43 upstream of the BCK2 branch of the PKC1 signalling pathway , since cwh43 mutations were synthetic lethal with pkc1 deletion , whereas the cwh43 defects could be rescued by overexpression of BCK2 and not by high - copy - number expression of genes encoding downstream proteins of the PKC1 pathway However , unlike BCK2 , whose disruption in a cln3 mutant resulted in growth arrest in G ( 1 ) , no growth defect was observed in a double cwh43 cln3 mutants .", "entity": [{"entity": "CWH43", "entity_type": "GENE", "pos": [24, 29]}, {"entity": "BCK2", "entity_type": "GENE", "pos": [46, 50]}, {"entity": "PKC1", "entity_type": "GENE", "pos": [65, 69]}, {"entity": "cwh43", "entity_type": "GENE", "pos": [97, 102]}, {"entity": "pkc1", "entity_type": "GENE", "pos": [140, 144]}, {"entity": "cwh43", "entity_type": "GENE", "pos": [168, 173]}, {"entity": "BCK2", "entity_type": "GENE", "pos": [220, 224]}, {"entity": "PKC1", "entity_type": "GENE", "pos": [313, 317]}, {"entity": "BCK2", "entity_type": "GENE", "pos": [343, 347]}, {"entity": "cln3 mutant", "entity_type": "GENE", "pos": [372, 383]}, {"entity": "cwh43", "entity_type": "GENE", "pos": [465, 470]}, {"entity": "cln3 mutants", "entity_type": "GENE", "pos": [471, 483]}], "task": "NER"}
{"text": "Expression of the E2 protein resulted in rapid repression of HPV E6 and E7 expression , followed approximately 12 h later by profound inhibition of cellular DNA synthesis .", "entity": [{"entity": "E2 protein", "entity_type": "GENE", "pos": [18, 28]}, {"entity": "HPV E6", "entity_type": "GENE", "pos": [61, 67]}, {"entity": "E7", "entity_type": "GENE", "pos": [72, 74]}], "task": "NER"}
{"text": "Peak reactive hyperemia ( mL . min - 1 . 100 mL - 1 ) was determined in the calf and forearm immediately before and after 12 weeks of training .", "entity": [], "task": "NER"}
{"text": "The hematopoietic form of PTPN6 transcript is initiated at a downstream promoter separated by 7 kb from the first .", "entity": [{"entity": "PTPN6 transcript", "entity_type": "GENE", "pos": [26, 42]}], "task": "NER"}
{"text": "Reversal of biliary sphincter spasm with low dose glucagon during operative cholangiography .", "entity": [{"entity": "glucagon", "entity_type": "GENE", "pos": [50, 58]}], "task": "NER"}
{"text": "In ten other endotoxin - albumin - treated pigs PGE1 infusion ( 0 . 25 micrograms X kg - 1 X min - 1 ) was begun after established pulmonary and cardiovascular dysfunction , for closer mimicking of clinical use .", "entity": [{"entity": "albumin", "entity_type": "GENE", "pos": [25, 32]}], "task": "NER"}
{"text": "In particular , MF males receiving either a 5 . 0 - mg / kg CDP dose or a 3 . 0 - mg / kg RO dose explored the object more often than MM males . ( ABSTRACT TRUNCATED AT 250 WORDS )", "entity": [], "task": "NER"}
{"text": "A single HD session using cellulose triacetate or polysulfone membrane significantly increased water content both at forearm and lower leg ( p < 0 . 05 ) .", "entity": [], "task": "NER"}
{"text": "In the yeast two - hybrid assays , PNRC interacted with the orphan receptors SF1 and ERRalpha1 in a ligand - independent manner .", "entity": [{"entity": "PNRC", "entity_type": "GENE", "pos": [35, 39]}, {"entity": "SF1", "entity_type": "GENE", "pos": [77, 80]}, {"entity": "ERRalpha1", "entity_type": "GENE", "pos": [85, 94]}], "task": "NER"}
{"text": "Further , we will review our evaluation of the survival rate and prognostic factors for 9 , 262 patients from 1981 to 1996 .", "entity": [], "task": "NER"}
{"text": "Kaposi ' s eruptive disease .", "entity": [], "task": "NER"}
{"text": "The results were subjected to analysis of 23 autopsies carried out in children dying of intoxication with Amanita phalloides .", "entity": [], "task": "NER"}
{"text": "Microscopic examination of these colonies showed a high percentage of histiocytes identical to those seen in the patient ' s bone marrow .", "entity": [], "task": "NER"}
{"text": "Diffusion epidemic models with incubation and crisscross dynamics .", "entity": [], "task": "NER"}
{"text": "Additional genetic analyses described herein suggest that Skb1 is a component of the morphology control branch of the Ras signaling cascade in S . pombe and that it positively modulates Shk1 function .", "entity": [{"entity": "Skb1", "entity_type": "GENE", "pos": [58, 62]}, {"entity": "Ras", "entity_type": "GENE", "pos": [118, 121]}, {"entity": "Shk1", "entity_type": "GENE", "pos": [186, 190]}], "task": "NER"}
{"text": "Transient transfection assays indicated that the ( - 4551 ) UCP1 - CAT construct , containing the 5 ' - regulatory region of the rat ucp - 1 gene , was activated by PPARalpha co - transfection in a dose - dependent manner and this activation was potentiated by Wy 14 , 643 and retinoid X receptor alpha .", "entity": [{"entity": "UCP1", "entity_type": "GENE", "pos": [60, 64]}, {"entity": "CAT", "entity_type": "GENE", "pos": [67, 70]}, {"entity": "rat ucp - 1 gene", "entity_type": "GENE", "pos": [129, 145]}, {"entity": "PPARalpha", "entity_type": "GENE", "pos": [165, 174]}, {"entity": "retinoid X receptor alpha", "entity_type": "GENE", "pos": [277, 302]}], "task": "NER"}
{"text": "CRKL , an SH2 - SH3 - SH3 adapter protein , is one of the major tyrosine phosphoproteins detected in primary leukemic neutrophils from patients with CML .", "entity": [{"entity": "CRKL", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "SH2", "entity_type": "GENE", "pos": [10, 13]}, {"entity": "SH3", "entity_type": "GENE", "pos": [16, 19]}, {"entity": "SH3", "entity_type": "GENE", "pos": [22, 25]}, {"entity": "tyrosine phosphoproteins", "entity_type": "GENE", "pos": [64, 88]}], "task": "NER"}
{"text": "Idealized versus realized overall treatment times .", "entity": [], "task": "NER"}
{"text": "Serum C3 was measured in 1 , 282 school children with abnormal urinary findings between 1980 and 1997 .", "entity": [{"entity": "Serum C3", "entity_type": "GENE", "pos": [0, 8]}], "task": "NER"}
{"text": "Tc - 99m HMPAO brain SPECT compared to CT and EEG after seizures in childhood .", "entity": [], "task": "NER"}
{"text": "The adenovirus E1B 19 , 000 - molecular - weight ( 19K ) protein is a potent inhibitor of apoptosis and cooperates with E1A to transform primary rodent cells .", "entity": [{"entity": "adenovirus E1B 19 , 000 - molecular - weight ( 19K ) protein", "entity_type": "GENE", "pos": [4, 64]}, {"entity": "E1A", "entity_type": "GENE", "pos": [120, 123]}], "task": "NER"}
{"text": "Subclones of R15 which reverted to kappa light chain production contained genomic deletions of R15ns and / or the surrounding intron .", "entity": [{"entity": "kappa light chain", "entity_type": "GENE", "pos": [35, 52]}], "task": "NER"}
{"text": "Previous data suggested a subtle increase in serum P at the time of hCG injection without LH surge reduces the PR of women having oocyte retrievals for IVF ; this study compared PRs of recipients in a shared oocyte program according to the donors ' pre - hCG P level .", "entity": [{"entity": "hCG", "entity_type": "GENE", "pos": [68, 71]}, {"entity": "LH", "entity_type": "GENE", "pos": [90, 92]}, {"entity": "pre - hCG", "entity_type": "GENE", "pos": [249, 258]}], "task": "NER"}
{"text": "Scleraxis overexpression enhanced expression of the aggrecan gene , which is not normally expressed at high levels in these osteoblastic cells .", "entity": [{"entity": "Scleraxis", "entity_type": "GENE", "pos": [0, 9]}, {"entity": "aggrecan gene", "entity_type": "GENE", "pos": [52, 65]}], "task": "NER"}
{"text": "Region - specific enhancers near two mammalian homeo box genes define adjacent rostrocaudal domains in the central nervous system .", "entity": [{"entity": "mammalian homeo box genes", "entity_type": "GENE", "pos": [37, 62]}], "task": "NER"}
{"text": "Cells were cotransfected with this plasmid , and the appropriate responder plasmids and clonies were selected on the basis of their resistance to Geneticin ( via the neomycin aminoglycoside phosphotransferase gene ) .", "entity": [{"entity": "neomycin aminoglycoside phosphotransferase gene", "entity_type": "GENE", "pos": [166, 213]}], "task": "NER"}
{"text": "To clone cDNAs for the beta subunit of rabbit eIF - 2B , amino acid sequence data was first obtained and used to design redundant oligonucleotide primers for use in PCR .", "entity": [{"entity": "rabbit eIF - 2B", "entity_type": "GENE", "pos": [39, 54]}], "task": "NER"}
{"text": "Deletion analysis of the 3 . 5kb DNA fragment revealed that the region between - 125 to + 1 , containing a single Sp1 binding site , is essential for transcription of the embigin gene .", "entity": [{"entity": "Sp1 binding site", "entity_type": "GENE", "pos": [114, 130]}, {"entity": "embigin gene", "entity_type": "GENE", "pos": [171, 183]}], "task": "NER"}
{"text": "A 29 . 425 kb segment on the left arm of yeast chromosome XV contains more than twice as many unknown as known open reading frames .", "entity": [], "task": "NER"}
{"text": "By applying a sufficiently strong crusher gradient in the EPI pulse sequence , the temporal variation induced by SSFP disturbance can be suppressed due to diffusion .", "entity": [], "task": "NER"}
{"text": "The cdc42W97R temperature - sensitive allele in S . cerevisiae displayed the same cell - division - cycle arrest phenotype ( large , round unbudded cells ) as the cdc42 - 1ts mutant .", "entity": [{"entity": "cdc42W97R temperature - sensitive allele", "entity_type": "GENE", "pos": [4, 44]}, {"entity": "cdc42 - 1ts mutant", "entity_type": "GENE", "pos": [163, 181]}], "task": "NER"}
{"text": "Wolf - Hirschhorn syndrome ( WHS ) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4 ( 4p16 . 3 ) .", "entity": [], "task": "NER"}
{"text": "To address this question with respect to skeletal muscle , we have examined the effects of the Providence mutation in cultured muscle cells , after adoptive gene transfer to adult mice , and in two infants homozygous for spectrin Providence .", "entity": [{"entity": "spectrin Providence", "entity_type": "GENE", "pos": [221, 240]}], "task": "NER"}
{"text": "Adenovirus - mediated gene transfer of MMAC1 / PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E / CDK2 complexes .", "entity": [{"entity": "MMAC1", "entity_type": "GENE", "pos": [39, 44]}, {"entity": "PTEN", "entity_type": "GENE", "pos": [47, 51]}, {"entity": "p27Kip1", "entity_type": "GENE", "pos": [119, 126]}, {"entity": "cyclin E", "entity_type": "GENE", "pos": [132, 140]}, {"entity": "CDK2", "entity_type": "GENE", "pos": [143, 147]}], "task": "NER"}
{"text": "Increasing insulin sensitivity in type I diabetic patients should alert clinicians to the possibility of glucocorticoid deficiency .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [11, 18]}], "task": "NER"}
{"text": "Experiment B : Clinical , biochemical , and histological variables were measured over a 12 - day period after the zymosan had been given .", "entity": [], "task": "NER"}
{"text": "Lesions of this kind resemble those in vitamin A - deficient chickens and are the first to be induced by excess vitamin E .", "entity": [], "task": "NER"}
{"text": "Immunoblotting using a phosphospecific anti - Src ( 416Y ) antibody showed a ceramide - induced increase in pp60 ( src ) tyrosine phosphorylation .", "entity": [{"entity": "phosphospecific anti - Src ( 416Y ) antibody", "entity_type": "GENE", "pos": [23, 67]}, {"entity": "pp60", "entity_type": "GENE", "pos": [108, 112]}, {"entity": "src", "entity_type": "GENE", "pos": [115, 118]}], "task": "NER"}
{"text": "Spinophilin , a novel protein phosphatase 1 binding protein localized to dendritic spines .", "entity": [{"entity": "Spinophilin", "entity_type": "GENE", "pos": [0, 11]}, {"entity": "protein phosphatase 1 binding protein", "entity_type": "GENE", "pos": [22, 59]}], "task": "NER"}
{"text": "The Htf9 - a gene encodes the RanBP1 protein , a major partner of the Ran GTPase .", "entity": [{"entity": "Htf9 - a gene", "entity_type": "GENE", "pos": [4, 17]}, {"entity": "RanBP1 protein", "entity_type": "GENE", "pos": [30, 44]}, {"entity": "Ran GTPase", "entity_type": "GENE", "pos": [70, 80]}], "task": "NER"}
{"text": "Membrane extraction has been interfaced with gas chromatography and mass spectroscopy for the analysis of volatile organics in water .", "entity": [], "task": "NER"}
{"text": "We have produced the Ure2 protein to high yield in Escherichia coli from a synthetic gene .", "entity": [{"entity": "Ure2 protein", "entity_type": "GENE", "pos": [21, 33]}], "task": "NER"}
{"text": "Triethylene glycol .", "entity": [], "task": "NER"}
{"text": "The SM - specific selection of exon 2 results from the inhibition of exon 3 .", "entity": [], "task": "NER"}
{"text": "Ultimobranchial body and parathyroid glands of the freshwater snake Natrix piscator in response to vitamin D3 administration .", "entity": [], "task": "NER"}
{"text": "In contrast to the p16 - mediated G1 block , G1 arrest mediated by the cdk inhibitors p21Cip1 or p27Kip1 cannot be bypassed either by inactivation of pRb or overexpression of E2F family members .", "entity": [{"entity": "p16", "entity_type": "GENE", "pos": [19, 22]}, {"entity": "cdk", "entity_type": "GENE", "pos": [71, 74]}, {"entity": "p21Cip1", "entity_type": "GENE", "pos": [86, 93]}, {"entity": "p27Kip1", "entity_type": "GENE", "pos": [97, 104]}, {"entity": "pRb", "entity_type": "GENE", "pos": [150, 153]}, {"entity": "E2F family members", "entity_type": "GENE", "pos": [175, 193]}], "task": "NER"}
{"text": "More than 80 % appropriate lever responding was established after 27 , 38 and 44 daily training sessions with DN - 2327 , diazepam and PTZ , respectively , as the training drug .", "entity": [], "task": "NER"}
{"text": "In the present study , we have investigated the effects of SDZ ENA 713 on spatial learning deficits in aged rats .", "entity": [], "task": "NER"}
{"text": "A retrospective analysis of data accumulated over a 21 - month period , from December 1989 to September 1991 , regarding investigational use of a 308 nanometer Xenon Chloride Excimer Laser Coronary Angioplasty ( ELCA ) system ( Advanced Interventional Systems , Inc . , Irvine , CA ) was performed .", "entity": [], "task": "NER"}
{"text": "Upon increasing the Marangoni number beyond this threshold , the initially stationary flow becomes quickly time dependent .", "entity": [], "task": "NER"}
{"text": "Investigation on the asymmetrical induced yields in 90Sr - 90Y - beta - irradiated D - and L - alanines .", "entity": [], "task": "NER"}
{"text": "One of the major transcripts encodes MEQ , a 339 - amino - acid bZIP protein which is homologous to the Jun / Fos family of transcription factors .", "entity": [{"entity": "MEQ", "entity_type": "GENE", "pos": [37, 40]}, {"entity": "bZIP protein", "entity_type": "GENE", "pos": [64, 76]}, {"entity": "Jun", "entity_type": "GENE", "pos": [104, 107]}, {"entity": "Fos", "entity_type": "GENE", "pos": [110, 113]}], "task": "NER"}
{"text": "Given a rapid induction of Egr - 1 on stimulation with growth factors or injury , these findings may represent at least one of the molecular mechanisms underlying phenotypic modulation of smooth muscles after vascular injury .", "entity": [{"entity": "Egr - 1", "entity_type": "GENE", "pos": [27, 34]}], "task": "NER"}
{"text": "An identical polypeptide was detected by Western blot analysis of K1F virions .", "entity": [], "task": "NER"}
{"text": "The predictive value of the remotely sensed map based on NDVI data appears to be better than that from forecast indices based only on climatic data .", "entity": [], "task": "NER"}
{"text": "The concentration of vitamin B1 , B2 and B6 are found to be 9 . 96 , 9 . 92 and 3 . 01 mg , respectively in 240 mg of capsule powder of a standard company ( name has not been disclosed due to secrecy purpose ) .", "entity": [], "task": "NER"}
{"text": "We have shown that the human cell MRC closely resembles the murine cell MRC , in both its protein composition and its fractionation and chromatographic profile .", "entity": [], "task": "NER"}
{"text": "Red blood cell binding of 99mTc - EC and 131I - OIH was 6 . 1 % and 20 % , respectively .", "entity": [], "task": "NER"}
{"text": "Identification of a 68 - kilodalton nuclear ATP - binding phosphoprotein encoded by bovine papillomavirus type 1 .", "entity": [{"entity": "68 - kilodalton nuclear ATP - binding phosphoprotein", "entity_type": "GENE", "pos": [20, 72]}], "task": "NER"}
{"text": "To identify the GRK6 homologue on chromsome 13 , several sets of closely - spaced primers were designed based on the GRK6 cDNA sequence and then used to amplify human genomic DNA by PCR .", "entity": [{"entity": "GRK6 homologue", "entity_type": "GENE", "pos": [16, 30]}, {"entity": "GRK6 cDNA sequence", "entity_type": "GENE", "pos": [117, 135]}], "task": "NER"}
{"text": "During the burst period ( approximately 5 - 10 min ) , local blood H2O2 concentrations and xanthine oxidase activities were highly correlated ( r = 0 . 999 ) .", "entity": [{"entity": "xanthine oxidase", "entity_type": "GENE", "pos": [91, 107]}], "task": "NER"}
{"text": "This mutant also functions in vivo as a trans - acting dominant negative regulator : the transcriptional inducibility of the HIV long terminal repeat ( which contains two potential NF - kappa B binding sites ) by phorbol ester ( PMA ) is inhibited when it is co - transfected into CD4 + T cells with the delta SP mutant .", "entity": [{"entity": "HIV long terminal repeat", "entity_type": "GENE", "pos": [125, 149]}, {"entity": "NF - kappa B binding sites", "entity_type": "GENE", "pos": [181, 207]}, {"entity": "CD4 +", "entity_type": "GENE", "pos": [281, 286]}], "task": "NER"}
{"text": "We demonstrate that the WRM - 1 protein binds to LIT - 1 in vivo and that WRM - 1 can activate the LIT - 1 protein kinase when coexpressed in vertebrate tissue culture cells .", "entity": [{"entity": "WRM - 1 protein", "entity_type": "GENE", "pos": [24, 39]}, {"entity": "LIT - 1", "entity_type": "GENE", "pos": [49, 56]}, {"entity": "WRM - 1", "entity_type": "GENE", "pos": [74, 81]}, {"entity": "LIT - 1 protein kinase", "entity_type": "GENE", "pos": [99, 121]}], "task": "NER"}
{"text": "To assess the safety of the angiotensin converting enzyme inhibitor enalapril a multicenter , open , randomized , prazosin - controlled trial was designed comparing the incidence and severity of symptomatic hypotension on the first day of treatment .", "entity": [{"entity": "angiotensin converting enzyme", "entity_type": "GENE", "pos": [28, 57]}], "task": "NER"}
{"text": "Mutating bases - 142 to - 151 abolishes formation of complex VII and partially inhibits complex IV , suggesting that the proteins forming these complexes bind neighboring segments of DNA .", "entity": [], "task": "NER"}
{"text": "In this study , we report the cloning and sequencing of several overlapping cDNAs encoding approximately 4 . 1 kb of the human homologue of Wnt - 5A .", "entity": [{"entity": "human homologue of Wnt - 5A", "entity_type": "GENE", "pos": [121, 148]}], "task": "NER"}
{"text": "We provided evidence that CaM kinase II played a role in regulating neurite outgrowth and growth cone motility in these cells , and that the autophosphorylation is essential for the kinase to sufficiently exert its cellular function in vivo [ Y .", "entity": [{"entity": "CaM kinase II", "entity_type": "GENE", "pos": [26, 39]}], "task": "NER"}
{"text": "We propose that GCD7 and GCD2 play important roles in the regulatory interaction between eIF - 2 and eIF - 2B and that the suppressor mutations we isolated in these genes decrease the susceptibility of eIF - 2B to the inhibitory effects of phosphorylated eIF - 2 without impairing the essential catalytic function of eIF - 2B in translation initiation .", "entity": [{"entity": "GCD7", "entity_type": "GENE", "pos": [16, 20]}, {"entity": "GCD2", "entity_type": "GENE", "pos": [25, 29]}, {"entity": "eIF - 2", "entity_type": "GENE", "pos": [89, 96]}, {"entity": "eIF - 2B", "entity_type": "GENE", "pos": [101, 109]}, {"entity": "eIF - 2B", "entity_type": "GENE", "pos": [202, 210]}, {"entity": "eIF - 2", "entity_type": "GENE", "pos": [255, 262]}, {"entity": "eIF - 2B", "entity_type": "GENE", "pos": [317, 325]}], "task": "NER"}
{"text": "Furthermore , we demonstrate that in myeloid and B cell extracts , PU . 1 forms a novel , specific , more slowly migrating complex ( PU - SF ) when binding the GM - CSF receptor alpha promoter PU . 1 site .", "entity": [{"entity": "PU . 1", "entity_type": "GENE", "pos": [67, 73]}, {"entity": "PU - SF", "entity_type": "GENE", "pos": [133, 140]}, {"entity": "GM - CSF receptor alpha", "entity_type": "GENE", "pos": [160, 183]}, {"entity": "PU . 1", "entity_type": "GENE", "pos": [193, 199]}], "task": "NER"}
{"text": "The antiserum used for immunoblotting specifically supershifts uteroglobin promoter - protein complexes in gel shift experiments .", "entity": [{"entity": "uteroglobin promoter - protein complexes", "entity_type": "GENE", "pos": [63, 103]}], "task": "NER"}
{"text": "Plasma LH and progesterone levels after single or multiple injections of synthetic LH - RH in anoestrous ewes and comparison with levels during the oestrous cycle .", "entity": [{"entity": "Plasma LH", "entity_type": "GENE", "pos": [0, 9]}, {"entity": "LH", "entity_type": "GENE", "pos": [83, 85]}, {"entity": "RH", "entity_type": "GENE", "pos": [88, 90]}], "task": "NER"}
{"text": "Soluble recombinant RI and soluble recombinant C alpha can associate in vitro and be activated by cyclic AMP .", "entity": [{"entity": "RI", "entity_type": "GENE", "pos": [20, 22]}, {"entity": "C alpha", "entity_type": "GENE", "pos": [47, 54]}], "task": "NER"}
{"text": "We have isolated and structurally characterized genomic DNA and cDNA sequences encoding ribulose - 1 , 5 - bisphosphate carboxylase / oxygenase ( Rbu - P2 carboxylase ) activase from barley ( Hordeum vulgare L . ) .", "entity": [{"entity": "ribulose - 1 , 5 - bisphosphate carboxylase / oxygenase ( Rbu - P2 carboxylase ) activase", "entity_type": "GENE", "pos": [88, 177]}], "task": "NER"}
{"text": "Cytokine inducibility of VCAM1 in endothelial cells utilizes the interaction of heterodimeric p50 / p65 proteins with IRF - 1 .", "entity": [{"entity": "VCAM1", "entity_type": "GENE", "pos": [25, 30]}, {"entity": "p50", "entity_type": "GENE", "pos": [94, 97]}, {"entity": "p65", "entity_type": "GENE", "pos": [100, 103]}, {"entity": "IRF - 1", "entity_type": "GENE", "pos": [118, 125]}], "task": "NER"}
{"text": "The cases with terminal forces of left ventricular activation in the same direction as the delta wave , superiorly and to the left at - 60 degrees or inferiorly and to the right at + 120 degrees , forming a single deflection of over 0 , 12 seconds ' duration , are the result of delayed activation of the anterior or posterior fascicle of the left bundle after a long delay .", "entity": [], "task": "NER"}
{"text": "From a chromosomal cosmid library of Streptomyces argillaceus , a Mtm producer , a clone ( cosAR7 ) was isolated by homology to the actI / III region of S . coelicolor and the strDEM genes of S . griseus .", "entity": [{"entity": "Mtm", "entity_type": "GENE", "pos": [66, 69]}, {"entity": "actI / III region", "entity_type": "GENE", "pos": [132, 149]}, {"entity": "strDEM genes", "entity_type": "GENE", "pos": [176, 188]}], "task": "NER"}
{"text": "A 31 - year - old man with primary myelofibrosis initially received low dose Ara C .", "entity": [], "task": "NER"}
{"text": "The factors defective in groups A ( CIITA ) , C ( RFX5 ) and D ( RFXAP ) have been identified .", "entity": [{"entity": "CIITA", "entity_type": "GENE", "pos": [36, 41]}, {"entity": "RFX5", "entity_type": "GENE", "pos": [50, 54]}, {"entity": "RFXAP", "entity_type": "GENE", "pos": [65, 70]}], "task": "NER"}
{"text": "Manifestation of superfluidity in an evolving bose - einstein condensed Gas We study the generation of excitations due to an \" impurity \" ( static perturbation ) placed into an oscillating Bose - Einstein condensed gas in the time - dependent trapping field .", "entity": [], "task": "NER"}
{"text": "By sequencing of exonuclease III deletion clones an open reading frame of 405 nucleotides was found coding for a protein of 135 amino acids with a molecular mass of 15 kDa .", "entity": [{"entity": "exonuclease III", "entity_type": "GENE", "pos": [17, 32]}], "task": "NER"}
{"text": "The c - raf - 1 proto - oncogene is the cellular homologue of v - raf , the oncogene of the acutely transforming retrovirus 3611 - MSV .", "entity": [{"entity": "c - raf - 1 proto - oncogene", "entity_type": "GENE", "pos": [4, 32]}, {"entity": "cellular homologue of v - raf", "entity_type": "GENE", "pos": [40, 69]}], "task": "NER"}
{"text": "We report the genomic organization of the mouse orphan receptor related to tyrosine kinases ( Ryk ) , a structurally unclassified member of the growth factor receptor family .", "entity": [{"entity": "orphan receptor related to tyrosine kinases", "entity_type": "GENE", "pos": [48, 91]}, {"entity": "Ryk", "entity_type": "GENE", "pos": [94, 97]}, {"entity": "growth factor receptor", "entity_type": "GENE", "pos": [144, 166]}], "task": "NER"}
{"text": "Electrophoretic mobility - shift assays between viral RNA and BMV CP peptides with either proline or alanine substitutions revealed that the interaction is nonspecific .", "entity": [{"entity": "BMV CP peptides", "entity_type": "GENE", "pos": [62, 77]}], "task": "NER"}
{"text": "Furthermore , we detect hCoch - 5B2 on three overlapping YACs , two of which also contain one of the markers linked to DFNA9 . mCoch - 5B2 was genetically mapped in the mouse to chromosome 12 , in a region of homologous synteny with human 14q11 . 2 - q13 , which contains the asp1 ( audiogenic seizure prone ) locus in the mouse .", "entity": [{"entity": "hCoch - 5B2", "entity_type": "GENE", "pos": [24, 35]}, {"entity": "DFNA9", "entity_type": "GENE", "pos": [119, 124]}, {"entity": "mCoch - 5B2", "entity_type": "GENE", "pos": [127, 138]}, {"entity": "asp1", "entity_type": "GENE", "pos": [276, 280]}, {"entity": "audiogenic seizure prone", "entity_type": "GENE", "pos": [283, 307]}], "task": "NER"}
{"text": "Reasons are given for suggesting that tiapamil warrants further clinical evaluation , after which it may join the more established calcium antagonists as a valuable therapeutic agent .", "entity": [], "task": "NER"}
{"text": "Histopathologic studies displaying spongiform changes in the gray matter , neuronal loss , and atrogliosis confirmed the clinical diagnosis of Creutzfeldt - Jakob disease .", "entity": [], "task": "NER"}
{"text": "Current body size ( wt / ht2 ) was significantly associated with life - time weight dissatisfaction in both sexes ( P less than 0 . 0005 ) .", "entity": [], "task": "NER"}
{"text": "Our results are consistent with TCOF1 mutations leading to the Treacher Collins syndrome phenotype .", "entity": [{"entity": "TCOF1 mutations", "entity_type": "GENE", "pos": [32, 47]}], "task": "NER"}
{"text": "Mannich bases of vanillin oxime .", "entity": [], "task": "NER"}
{"text": "Its activity was twice that of a construct where the CAT gene was driven by the H - 2Kb 5 ' enhancer region ( H2TF1 / KBF1 site ) and comparable to that of pRSVCAT construct carrying the strong Rous sarcoma virus LTR enhancer .", "entity": [{"entity": "CAT gene", "entity_type": "GENE", "pos": [53, 61]}, {"entity": "H - 2Kb 5 ' enhancer region", "entity_type": "GENE", "pos": [80, 107]}, {"entity": "H2TF1", "entity_type": "GENE", "pos": [110, 115]}, {"entity": "KBF1", "entity_type": "GENE", "pos": [118, 122]}, {"entity": "construct carrying the strong Rous sarcoma virus LTR enhancer", "entity_type": "GENE", "pos": [164, 225]}], "task": "NER"}
{"text": "CONCLUSIONS : These findings imply that the spinal cord is not a simple command - carrying medium from the brain to the limbs , and implies that some computational activities take place at the spinal cord level .", "entity": [], "task": "NER"}
{"text": "The dipper ( RONF of BP ( or HR ) > or = 10 % 2 .", "entity": [], "task": "NER"}
{"text": "I .", "entity": [], "task": "NER"}
{"text": "Acute spontaneous subdural haematoma .", "entity": [], "task": "NER"}
{"text": "Nonsuicidal mortality in late - life depression .", "entity": [], "task": "NER"}
{"text": "DSS4 - 1 is a dominant suppressor of sec4 - 8 that encodes a nucleotide exchange protein that aids Sec4p function .", "entity": [{"entity": "DSS4 - 1", "entity_type": "GENE", "pos": [0, 8]}, {"entity": "sec4 - 8", "entity_type": "GENE", "pos": [37, 45]}, {"entity": "Sec4p", "entity_type": "GENE", "pos": [99, 104]}], "task": "NER"}
{"text": "A study of characteristics in adult asthmatics who are sensitized by cats and dogs allergens", "entity": [], "task": "NER"}
{"text": "The failure suggests that these assembly competent but complementation - negative alpha mutants lack an as yet unidentified function ( s ) .", "entity": [], "task": "NER"}
{"text": "Ciprofloxacin levels in serum and blister fluid at the end of the dosing interval ( 8 h ) were superior or almost superior to MICs for sensitive organisms including Pseudomonas aeruginosa .", "entity": [], "task": "NER"}
{"text": "However , both peptides 1 - 49 and 63 - 87 bound to PDE alpha / beta in a solid - phase binding assay .", "entity": [{"entity": "PDE alpha / beta", "entity_type": "GENE", "pos": [52, 68]}], "task": "NER"}
{"text": "SETTING : A private office - based fertility program .", "entity": [], "task": "NER"}
{"text": "Our results showed that direct enantiomeric separation of mephenytoin was obtained by using a chiral capillary column , the retention times for S - and R - mephenytoin were 25 . 5 and 26 . 2 min respectively , with a detection limit less than 50 ng / ml of mephenytoin .", "entity": [], "task": "NER"}
{"text": "The consensus mammalian ER stress response element ( ERSE ) conserved among grp promoters consists of a tripartite structure CCAAT ( N9 ) CCACG , with N being a strikingly GC - rich region of 9 bp .", "entity": [{"entity": "grp promoters", "entity_type": "GENE", "pos": [76, 89]}], "task": "NER"}
{"text": "Further , we find that the BMI1 protein can also interact with itself .", "entity": [{"entity": "BMI1 protein", "entity_type": "GENE", "pos": [27, 39]}], "task": "NER"}
{"text": "These data suggest that certain of the nuclear protein import functions of NTF2 and Ran / TC4 are closely linked and that NTF2 may serve to modulate a transport step involving Ran / TC4 .", "entity": [{"entity": "NTF2", "entity_type": "GENE", "pos": [75, 79]}, {"entity": "Ran", "entity_type": "GENE", "pos": [84, 87]}, {"entity": "TC4", "entity_type": "GENE", "pos": [90, 93]}, {"entity": "NTF2", "entity_type": "GENE", "pos": [122, 126]}, {"entity": "Ran", "entity_type": "GENE", "pos": [176, 179]}, {"entity": "TC4", "entity_type": "GENE", "pos": [182, 185]}], "task": "NER"}
{"text": "Our analysis indicates that a gene correction mechanism has been operating on the Hbbs chromosome to keep beta s and beta t evolving in concert , whereas on the Hbbd chromosome , beta dmin has diverged considerably from beta dmaj .", "entity": [{"entity": "Hbbs", "entity_type": "GENE", "pos": [82, 86]}, {"entity": "beta s", "entity_type": "GENE", "pos": [106, 112]}, {"entity": "beta t", "entity_type": "GENE", "pos": [117, 123]}, {"entity": "Hbbd", "entity_type": "GENE", "pos": [161, 165]}, {"entity": "beta dmin", "entity_type": "GENE", "pos": [179, 188]}, {"entity": "beta dmaj", "entity_type": "GENE", "pos": [220, 229]}], "task": "NER"}
{"text": "The prosomal RNA - binding protein p27K is a member of the alpha - type human prosomal gene family .", "entity": [{"entity": "prosomal RNA - binding protein p27K", "entity_type": "GENE", "pos": [4, 39]}, {"entity": "alpha - type human prosomal gene family", "entity_type": "GENE", "pos": [59, 98]}], "task": "NER"}
{"text": "Because controlled - release niacin seems to be more potent than crystalline niacin , product substitution without dose adjustment should be avoided .", "entity": [], "task": "NER"}
{"text": "Expression of the gene encoding transcription factor cyclic adenosine 3 ' , 5 ' - monophosphate ( cAMP ) response element - binding protein ( CREB ) : regulation by follicle - stimulating hormone - induced cAMP signaling in primary rat Sertoli cells .", "entity": [{"entity": "transcription factor cyclic adenosine 3 ' , 5 ' - monophosphate ( cAMP ) response element - binding protein", "entity_type": "GENE", "pos": [32, 139]}, {"entity": "CREB", "entity_type": "GENE", "pos": [142, 146]}, {"entity": "follicle - stimulating hormone", "entity_type": "GENE", "pos": [165, 195]}], "task": "NER"}
{"text": "Comparison of the therapeutic effectiveness of membrane and centrifugation plasmapheresis", "entity": [], "task": "NER"}
{"text": "Number of warm - units with higher rates of firing and greater thermal coefficients , comparable to those of warm - units in the adult , gradually increased with growth .", "entity": [], "task": "NER"}
{"text": "To investigate the effect of hyperthyroidism on the pattern and time course of O2 uptake ( VO2 ) following the transition from rest to exercise , six patients and six healthy subjects performed cycle exercise at an average work rate ( WR ) of 18 and 20 W respectively .", "entity": [], "task": "NER"}
{"text": "88 , 3739 - 3743 ) ) .", "entity": [], "task": "NER"}
{"text": "CHIEF OUTCOME MEASURES : Endoluminal release of prostacyclin ( 6 - Keto - PGF1 alpha ) and thromboxane B2 ( TxB2 ) , patency , EC coverage and cell identity .", "entity": [], "task": "NER"}
{"text": "Elevated systolic blood pressure and high postglucose serum insulin levels showed an independent , significant association with left ventricular mass in female diabetic subjects .", "entity": [{"entity": "serum insulin", "entity_type": "GENE", "pos": [54, 67]}], "task": "NER"}
{"text": "Seasonal variation of the cadmium content of Murex trunculus in a non - cadmium polluted environment .", "entity": [], "task": "NER"}
{"text": "The total area under the blood glucose curve over the initial value was not altered 2 h after treatment with SH B 209 AB or Neogynon .", "entity": [], "task": "NER"}
{"text": "Serum IgM levels showed a highly significant increase in all types of brain tumour when compared to controls .", "entity": [{"entity": "Serum IgM", "entity_type": "GENE", "pos": [0, 9]}], "task": "NER"}
{"text": "Here we describe the characterization of cDNAs encoding two unusual E2Fs , E2F - 4 and E2F - 5 , each identified by the ability of their gene product to interact with p130 in a yeast two - hybrid system .", "entity": [{"entity": "E2Fs", "entity_type": "GENE", "pos": [68, 72]}, {"entity": "E2F - 4", "entity_type": "GENE", "pos": [75, 82]}, {"entity": "E2F - 5", "entity_type": "GENE", "pos": [87, 94]}, {"entity": "p130", "entity_type": "GENE", "pos": [167, 171]}], "task": "NER"}
{"text": "Ultra - energy ( UHE ) imaging is usually performed in simultaneous F - 18 FDG / Tc - 99m MIBI studies .", "entity": [], "task": "NER"}
{"text": "However , electron microscopy revealed that while sec4 mutant cells accumulate secretory vesicles , ypt31 / 32 mutant cells accumulate aberrant Golgi structures .", "entity": [{"entity": "sec4 mutant", "entity_type": "GENE", "pos": [50, 61]}, {"entity": "ypt31 / 32 mutant", "entity_type": "GENE", "pos": [100, 117]}], "task": "NER"}
{"text": "Furthermore , Grap is associated with a Ras guanine nucleotide exchange factor mSos1 , primarily through its N - terminal SH3 domain .", "entity": [{"entity": "Grap", "entity_type": "GENE", "pos": [14, 18]}, {"entity": "Ras guanine nucleotide exchange factor", "entity_type": "GENE", "pos": [40, 78]}, {"entity": "mSos1", "entity_type": "GENE", "pos": [79, 84]}, {"entity": "N - terminal SH3 domain", "entity_type": "GENE", "pos": [109, 132]}], "task": "NER"}
{"text": "Correlation of nitrogen , carbohydrate and lipid metabolic indices in rats cooled under conditions of an altered gaseous environment", "entity": [], "task": "NER"}
{"text": "Transfer of F - like plasmids is regulated by the FinOP system , which controls the expression of traJ , a positive regulator of the transfer operon .", "entity": [{"entity": "FinOP", "entity_type": "GENE", "pos": [50, 55]}, {"entity": "traJ", "entity_type": "GENE", "pos": [98, 102]}], "task": "NER"}
{"text": "This regimen may be considered front - line therapy when autologous stem cell transplantation is not feasible and when a rapid response is particularly important .", "entity": [], "task": "NER"}
{"text": "To investigate this issue , we used a recognition task in which two strings of letters are presented sequentially .", "entity": [], "task": "NER"}
{"text": "Comparison to the murine homologues of these molecules reveals a high degree of conservation between the products of one of these genes , Fc gamma RIIb , and the murine beta gene in primary sequence , splicing pattern , and tissue distribution .", "entity": [{"entity": "Fc gamma RIIb", "entity_type": "GENE", "pos": [138, 151]}, {"entity": "murine beta gene", "entity_type": "GENE", "pos": [162, 178]}], "task": "NER"}
{"text": "A rabbit antiserum raised against a unique ( V3 domain ) bacterially expressed PKC theta fragment immunoprecipitated specifically an 82 - kDa protein from Jurkat cell lysates .", "entity": [{"entity": "PKC theta fragment", "entity_type": "GENE", "pos": [79, 97]}], "task": "NER"}
{"text": "These changes persisted during the first week .", "entity": [], "task": "NER"}
{"text": "Hematological parameters ( leukocyte , neutrophil and platelet counts ) and liver function tests were determined by standard procedures .", "entity": [], "task": "NER"}
{"text": "( 1993 ) 8 , 94 - 99 ) .", "entity": [], "task": "NER"}
{"text": "The effect of betamethasone on duodenal calcium absorption and 1 , 25 - dihydroxy vitamin D3 production in the chick .", "entity": [], "task": "NER"}
{"text": "Phosphate compounds in isolated , perfused hearts during pH variation due to changes in extracellular PCO2 and bicarbonate", "entity": [], "task": "NER"}
{"text": "We report on a case discovered in a 13 year - old girl presenting with anaemia .", "entity": [], "task": "NER"}
{"text": "Although analysis of the similarity between the 44 - kDa protein and the E . coli RecA protein did not show any significant homology between them , it revealed their identity by five amino - acid residues involved in the formation of the epitope that recognized the paratope of the RecA protein antibody for subsequent epitope - paratope binding of these proteins .", "entity": [{"entity": "E . coli RecA protein", "entity_type": "GENE", "pos": [73, 94]}, {"entity": "RecA protein antibody", "entity_type": "GENE", "pos": [282, 303]}], "task": "NER"}
{"text": "It would seem that caution should be exercised in using HPL values as an index of placental function in anaemic women .", "entity": [{"entity": "HPL", "entity_type": "GENE", "pos": [56, 59]}], "task": "NER"}
{"text": "No IORT related mortality has been observed .", "entity": [], "task": "NER"}
{"text": "Characterization of a tonB - phoA gene fusion suggests that the amino - terminal 41 amino acids of TonB are sufficient to promote export of the fusion protein and presumably TonB as well .", "entity": [{"entity": "tonB", "entity_type": "GENE", "pos": [22, 26]}, {"entity": "phoA", "entity_type": "GENE", "pos": [29, 33]}, {"entity": "TonB", "entity_type": "GENE", "pos": [99, 103]}, {"entity": "TonB", "entity_type": "GENE", "pos": [174, 178]}], "task": "NER"}
{"text": "Characterization of a unique protein component of yeast RNase MRP : an RNA - binding protein with a zinc - cluster domain .", "entity": [{"entity": "yeast RNase MRP", "entity_type": "GENE", "pos": [50, 65]}], "task": "NER"}
{"text": "This raises the possibility that recombination occurred between corresponding LTR and vif loci of the quasi - species present in the isolates described here .", "entity": [{"entity": "vif loci", "entity_type": "GENE", "pos": [86, 94]}], "task": "NER"}
{"text": "2 .", "entity": [], "task": "NER"}
{"text": "The antihypertensive action corresponds to those of established diuretics .", "entity": [], "task": "NER"}
{"text": "These results are discussed in relation to predicted isoform L diversity across human tissues and cells .", "entity": [], "task": "NER"}
{"text": "In the healing tendons , the rate of collagen synthesis decreased and the rate of noncollagen protein synthesis remained unchanged .", "entity": [{"entity": "collagen", "entity_type": "GENE", "pos": [37, 45]}], "task": "NER"}
{"text": "The aromatic hydrocarbon receptor ( AHR ) is a ligand - activated transcription factor that regulates the expression of several drug - metabolizing enzymes and has been implicated in immunosuppression , teratogenesis , cell - specific hyperplasia , and certain types of malignancies and toxicities .", "entity": [{"entity": "aromatic hydrocarbon receptor", "entity_type": "GENE", "pos": [4, 33]}, {"entity": "AHR", "entity_type": "GENE", "pos": [36, 39]}], "task": "NER"}
{"text": "Fluctuations of the measured ECF energy - related substances corresponded to various clinical events presumably involving hypoxia / ischemia .", "entity": [], "task": "NER"}
{"text": "After 3 months of intervention , sustained physical training was associated with the decrease of FVII and PAI - 1 levels .", "entity": [{"entity": "FVII", "entity_type": "GENE", "pos": [97, 101]}, {"entity": "PAI - 1", "entity_type": "GENE", "pos": [106, 113]}], "task": "NER"}
{"text": "The metalloproteinase mediating Met cleavage was specifically inhibited by the tissue inhibitor of metalloproteinases ( TIMP ) - 3 , but not by TIMP - 1 or TIMP - 2 .", "entity": [{"entity": "metalloproteinase", "entity_type": "GENE", "pos": [4, 21]}, {"entity": "Met", "entity_type": "GENE", "pos": [32, 35]}, {"entity": "tissue inhibitor of metalloproteinases ( TIMP ) - 3", "entity_type": "GENE", "pos": [79, 130]}, {"entity": "TIMP - 1", "entity_type": "GENE", "pos": [144, 152]}, {"entity": "TIMP - 2", "entity_type": "GENE", "pos": [156, 164]}], "task": "NER"}
{"text": "This constant expression profile , coupled with the observation that over - expression of mSin3A does not augment the anti - Myc activity of Mxi1 - SR in the rat embryo fibroblast ( REF ) transformation assay , suggests that mSin3A is not a limiting factor in the regulation of Myc superfamily function .", "entity": [{"entity": "mSin3A", "entity_type": "GENE", "pos": [90, 96]}, {"entity": "anti - Myc", "entity_type": "GENE", "pos": [118, 128]}, {"entity": "Mxi1", "entity_type": "GENE", "pos": [141, 145]}, {"entity": "mSin3A", "entity_type": "GENE", "pos": [225, 231]}, {"entity": "Myc superfamily", "entity_type": "GENE", "pos": [278, 293]}], "task": "NER"}
{"text": "METHODS AND RESULTS : The effect of prolonged nitrate therapy between 2 days and 6 weeks during healing after infarction on serial parameters of ventricular remodeling ( scar expansion , scar thinning , ventricular dilation , and hypertrophy ) and function ( asynergy or akinesis plus dyskinesis and ejection fraction ) by serial two - dimensional echocardiography , hemodynamics , postmortem topography ( computerized planimetry , geometric maps , and radiographs ) , and collagen content ( hydroxyproline ) was studied in 64 instrumented dogs randomized 2 days after left anterior descending coronary artery ligation to various nitrate regimens ( n = 32 ) over the first 2 weeks ( subgroup 1 : 2 % transdermal nitroglycerin at 8 AM and 4 PM , n = 6 ; subgroup 2 : 2 % transdermal nitroglycerin plus 2 . 6 mg of sustained - release oral nitroglycerin at 8 AM , 3 PM , and 10 PM , n = 5 ; subgroup 3 : oral isosorbide dinitrate , 30 mg at 8 AM and 4 PM , n = 11 ) or 6 weeks ( subgroup 4 : isosorbide dinitrate , n = 10 ) and in matching controls ( n = 32 ) .", "entity": [{"entity": "collagen", "entity_type": "GENE", "pos": [473, 481]}], "task": "NER"}
{"text": "A nationwide survey uncovered a tenfold variation between counties in the prescribing of IFNB .", "entity": [{"entity": "IFNB", "entity_type": "GENE", "pos": [89, 93]}], "task": "NER"}
{"text": "We have demonstrated that a putative HOX cofactor , PBX1A , participates in cooperative DNA binding with HOXA - 1 and the Deformed group protein HOXD - 4 .", "entity": [{"entity": "HOX cofactor", "entity_type": "GENE", "pos": [37, 49]}, {"entity": "PBX1A", "entity_type": "GENE", "pos": [52, 57]}, {"entity": "HOXA - 1", "entity_type": "GENE", "pos": [105, 113]}, {"entity": "Deformed", "entity_type": "GENE", "pos": [122, 130]}, {"entity": "HOXD - 4", "entity_type": "GENE", "pos": [145, 153]}], "task": "NER"}
{"text": "RESULTS - - 261 patients were enrolled into this study ; of these , 138 ( 53 % ) patients attended for repeat colposcopy and cytology at one year .", "entity": [], "task": "NER"}
{"text": "We have found that pro - IGF - 2 can initially form two disulfide isomers that undergo rearrangement to a single conformation in vivo .", "entity": [{"entity": "pro - IGF - 2", "entity_type": "GENE", "pos": [19, 32]}], "task": "NER"}
{"text": "Thus , primate vs . rodent promoter selectivity mediated by the TBP - TAFI complex is likely to be the result of cumulative subtle differences between individual subunits that lead to species - specific properties of RNA polymerase I transcription .", "entity": [{"entity": "TBP", "entity_type": "GENE", "pos": [64, 67]}, {"entity": "TAFI", "entity_type": "GENE", "pos": [70, 74]}, {"entity": "RNA polymerase I", "entity_type": "GENE", "pos": [217, 233]}], "task": "NER"}
{"text": "Anti - Jo - 1 antibody was not present .", "entity": [{"entity": "Anti - Jo - 1 antibody", "entity_type": "GENE", "pos": [0, 22]}], "task": "NER"}
{"text": "The structure and expression of the murine gene encoding granulocyte - macrophage colony stimulating factor : evidence for utilisation of alternative promoters .", "entity": [{"entity": "murine gene encoding granulocyte - macrophage colony stimulating factor", "entity_type": "GENE", "pos": [36, 107]}], "task": "NER"}
{"text": "Cotransfection of pINV - 2473 , a construct containing 2473 base pairs of hINV upstream sequence linked to luciferase , with POU homeodomain transcription factors Oct1 , Oct2 , Brn4 , SCIP , Skn1a or Skn1i , results in a strong suppression of basal promoter activity .", "entity": [{"entity": "hINV upstream sequence", "entity_type": "GENE", "pos": [74, 96]}, {"entity": "luciferase", "entity_type": "GENE", "pos": [107, 117]}, {"entity": "POU homeodomain transcription factors", "entity_type": "GENE", "pos": [125, 162]}, {"entity": "Oct1", "entity_type": "GENE", "pos": [163, 167]}, {"entity": "Oct2", "entity_type": "GENE", "pos": [170, 174]}, {"entity": "Brn4", "entity_type": "GENE", "pos": [177, 181]}, {"entity": "SCIP", "entity_type": "GENE", "pos": [184, 188]}, {"entity": "Skn1a", "entity_type": "GENE", "pos": [191, 196]}, {"entity": "Skn1i", "entity_type": "GENE", "pos": [200, 205]}], "task": "NER"}
{"text": "Central treatment unit saves nurses , adds income , improves care .", "entity": [], "task": "NER"}
{"text": "The Grb2 SH3 ( C ) binding region of Gab1 has significant homology to a region of the adapter protein SLP - 76 .", "entity": [{"entity": "Grb2", "entity_type": "GENE", "pos": [4, 8]}, {"entity": "SH3 ( C ) binding region", "entity_type": "GENE", "pos": [9, 33]}, {"entity": "Gab1", "entity_type": "GENE", "pos": [37, 41]}, {"entity": "adapter protein SLP - 76", "entity_type": "GENE", "pos": [86, 110]}], "task": "NER"}
{"text": "The QCS appears comparable with the MMSE and is quicker to administer .", "entity": [], "task": "NER"}
{"text": "A positive FTA - ABS - 19S - IgM test indicates the necessity of treatment .", "entity": [{"entity": "FTA - ABS - 19S - IgM", "entity_type": "GENE", "pos": [11, 32]}], "task": "NER"}
{"text": "A DNA binding protein was identified which binds to two novel target - like sequences : ( i ) at the 5 ' flanking site of the breakpoint junction of chromosome 8 in a patient with T - acute lymphoblastic leukemia ( ALL ) carrying the t ( 8 ; 14 ) ( q24 ; q11 ) rearrangement and ( ii ) on chromosome 1 in three of five T - ALL patients with the t ( 1 ; 14 ) ( p32 ; q11 ) rearrangement .", "entity": [], "task": "NER"}
{"text": "1988 ) .", "entity": [], "task": "NER"}
{"text": "The effect of iron on the toxigenicity of Vibrio cholerae .", "entity": [], "task": "NER"}
{"text": "The rest of the 3 ' untranslated sequences were common to both cDNA clones .", "entity": [], "task": "NER"}
{"text": "The anesthesiologist and the cardiac surgeon .", "entity": [], "task": "NER"}
{"text": "The three proteins copurified through several biochemical fractionation steps and could be coimmunoprecipitated by using antibodies against GCD1 or GCD2 .", "entity": [{"entity": "GCD1", "entity_type": "GENE", "pos": [140, 144]}, {"entity": "GCD2", "entity_type": "GENE", "pos": [148, 152]}], "task": "NER"}
{"text": "From 1998 to 1999 , a large number of community - acquired respiratory tract isolates of Streptococcus pneumoniae ( n = 566 ) , Haemophilus influenzae ( n = 513 ) and Moraxella catarrhalis ( n = 228 ) were collected from 15 centres in Australia , Hong Kong , Japan , China , the Philippines , Singapore , South Africa and Taiwan through the SENTRY Antimicrobial Surveillance Program .", "entity": [], "task": "NER"}
{"text": "Rats on the multiple oral dosage regimen were given unlabelled HMCF in their drinking water for 13 days before the administration of a bolus dose of [ 14C ] HMCF on day 14 .", "entity": [], "task": "NER"}
{"text": "In order to search for mutations in the multicopy RBM genes that might be associated with male infertility , we have used sequence data from the reported cDNA clone to determine the intron exon boundaries of the YRRM 1 gene .", "entity": [{"entity": "multicopy RBM genes", "entity_type": "GENE", "pos": [40, 59]}, {"entity": "YRRM 1 gene", "entity_type": "GENE", "pos": [212, 223]}], "task": "NER"}
{"text": "Uterine contractions began with a mean latency of 62 min in the PGF2 alpha infused women , in controls uterine activity remained unchanged .", "entity": [], "task": "NER"}
{"text": "The implication of Rac and Cdc42 was analyzed in transient transfection experiments using either constitutively active ( V12 ) or dominant - interfering ( N17 ) mutants .", "entity": [{"entity": "Rac", "entity_type": "GENE", "pos": [19, 22]}, {"entity": "Cdc42", "entity_type": "GENE", "pos": [27, 32]}], "task": "NER"}
{"text": "The evolutionary significance of the similarities of intron secondary structures and open reading frames of the ND3 , 4 and ATPase 6 genes is discussed , including the possible separate evolution of structural and coding sequences .", "entity": [{"entity": "ND3 , 4 and ATPase 6 genes", "entity_type": "GENE", "pos": [112, 138]}], "task": "NER"}
{"text": "Although there is evidence that cone ratios do determine colour appearance under many conditions , the site or sites of their computation is unknown .", "entity": [], "task": "NER"}
{"text": "Procedures with perfected method", "entity": [], "task": "NER"}
{"text": "In an effort to identify factors involved in the expression of this important erythroid - specific regulatory protein , we have isolated the mouse EKLF gene and systematically analyzed the promoter region .", "entity": [{"entity": "mouse EKLF gene", "entity_type": "GENE", "pos": [141, 156]}], "task": "NER"}
{"text": "Accordingly , superpeptide antigenic material was readily detected by immunoblotting cell extracts and enriched in vacuolar preparations of PrA deficient mutant cells .", "entity": [{"entity": "PrA", "entity_type": "GENE", "pos": [140, 143]}], "task": "NER"}
{"text": "RESULTS : All primary tumors were positive for CAM5 . 2 .", "entity": [{"entity": "CAM5 . 2", "entity_type": "GENE", "pos": [47, 55]}], "task": "NER"}
{"text": "However massive necrosis of the renal tubules had been found with more than 15mg of DSM administration .", "entity": [], "task": "NER"}
{"text": "A case of functioning parathyroid carcinoma with hypereninemic hypertension .", "entity": [], "task": "NER"}
{"text": "Together with a number of phase II trials , phase I trials utilizing escalating doses of carboplatin and paclitaxel with growth factor or growth factor and blood stem - cell support have shown that substantial increases in dose intensity can be achieved .", "entity": [], "task": "NER"}
{"text": "The study was performed in a class 100 laminar flow clean bench in order to minimize particulate contamination from extraneous sources .", "entity": [], "task": "NER"}
{"text": "Moreover , since the integrated transforming DNA was not altered or lost expression of the RbcS2 : : aadA : : RbcS2 gene ( s ) appears to be repressed .", "entity": [{"entity": "RbcS2", "entity_type": "GENE", "pos": [91, 96]}, {"entity": "aadA", "entity_type": "GENE", "pos": [101, 105]}, {"entity": "RbcS2 gene ( s )", "entity_type": "GENE", "pos": [110, 126]}], "task": "NER"}
{"text": "In contrast , the holo - dTFIIA ( L / S ) binds TBP with high affinity .", "entity": [{"entity": "holo - dTFIIA", "entity_type": "GENE", "pos": [18, 31]}, {"entity": "TBP", "entity_type": "GENE", "pos": [48, 51]}], "task": "NER"}
{"text": "In one trial , 116 subjects with transfusion - related chronic hepatitis C were treated with lymphoblastoid interferon ( 5 MU / m2 three times a week for 2 mo , then 3 MU / m2 three times a week for 4 or 10 mo ) .", "entity": [{"entity": "lymphoblastoid interferon", "entity_type": "GENE", "pos": [93, 118]}], "task": "NER"}
{"text": "These results demonstrate the preferential endometrial cell - type expression of BTEB and suggest its regulatory role in pregnancy - associated endometrial epithelial gene expression .", "entity": [{"entity": "BTEB", "entity_type": "GENE", "pos": [81, 85]}], "task": "NER"}
{"text": "The sequence of LZ321 matched that of RREB1 , a transcription factor that bound to a Ras responsive element ( RRE ) very different from the sequence with which we isolated LZ321 .", "entity": [{"entity": "LZ321", "entity_type": "GENE", "pos": [16, 21]}, {"entity": "RREB1", "entity_type": "GENE", "pos": [38, 43]}, {"entity": "Ras responsive element", "entity_type": "GENE", "pos": [85, 107]}, {"entity": "RRE", "entity_type": "GENE", "pos": [110, 113]}, {"entity": "LZ321", "entity_type": "GENE", "pos": [172, 177]}], "task": "NER"}
{"text": "Phosphorylation at Ser ( 670 ) impairs the ability of GRK2 to phosphorylate both soluble and membrane - incorporated receptor substrates and dramatically attenuates Gbetagamma - mediated activation of this enzyme .", "entity": [{"entity": "GRK2", "entity_type": "GENE", "pos": [54, 58]}, {"entity": "Gbetagamma", "entity_type": "GENE", "pos": [165, 175]}], "task": "NER"}
{"text": "However , the sequence of mRAR - beta 3 region A differs from that of mRAR - beta 1 by an additional 27 C - terminal amino acids encoded in an 81 nucleotide - long putative exon which is spliced in between the exons encoding the A and B regions of mRAR - beta 1 .", "entity": [{"entity": "mRAR - beta 3 region A", "entity_type": "GENE", "pos": [26, 48]}, {"entity": "mRAR - beta 1", "entity_type": "GENE", "pos": [70, 83]}, {"entity": "A and B regions of mRAR - beta 1", "entity_type": "GENE", "pos": [229, 261]}], "task": "NER"}
{"text": "Rad18 is required for DNA repair and checkpoint responses in fission yeast .", "entity": [{"entity": "Rad18", "entity_type": "GENE", "pos": [0, 5]}], "task": "NER"}
{"text": "The longest S1 - S2 interval at which S2 failed to capture ( effective refractory period ) was longer by 5 . 5 + / - 8 . 2 msec at twice threshold ( 0 . 05 less than p less than 0 . 10 ) and 5 . 5 + / - 3 . 5 msec at 5 times threshold stimulation ( p less than 0 . 01 ) when the basic drive and extrastimuli were delivered to separate sites .", "entity": [], "task": "NER"}
{"text": "Using lasers , PRK involves reshaping the cornea so that its refractive power is increased .", "entity": [], "task": "NER"}
{"text": "Using in vivo screening , we first identified a gene that appeared to interfere with the His - Asp phosphorelay between the HPt domain and the receiver domain of OmpR , provided that the gene product was expressed through a multicopy plasmid .", "entity": [{"entity": "OmpR", "entity_type": "GENE", "pos": [162, 166]}], "task": "NER"}
{"text": "In addition , six other landmarks favored the xeroradiograph but not to the degree of statistical significance .", "entity": [], "task": "NER"}
{"text": "Coronary vasoconstriction caused by endothelin - 1 is enhanced by ischemia - reperfusion and by norepinephrine present in concentrations typically observed after neonatal cardiopulmonary bypass .", "entity": [{"entity": "endothelin - 1", "entity_type": "GENE", "pos": [36, 50]}], "task": "NER"}
{"text": "Inhibition of Raf - 1 signaling by a monoclonal antibody , which interferes with Raf - 1 activation and with Mek substrate binding .", "entity": [{"entity": "Raf - 1", "entity_type": "GENE", "pos": [14, 21]}, {"entity": "Raf - 1", "entity_type": "GENE", "pos": [81, 88]}, {"entity": "Mek", "entity_type": "GENE", "pos": [109, 112]}], "task": "NER"}
{"text": "Laparoscopic examination 1 year after surgery revealed an enlarged , thin - walled , and fluid - filled uterine segment cranial to the midcornus occlusion sites in all animals .", "entity": [], "task": "NER"}
{"text": "NBSII is essential for ribosome - stimulated activity .", "entity": [], "task": "NER"}
{"text": "Gel shift and southwestern experiments revealed nuclear proteins of 43 kDa and 30 kDa in GC and fish cells , respectively , that bind specifically to the tGH CRE , suggesting the involvement of CRE - binding - protein / activating - transcription - factor - l - related peptides in cAMP response .", "entity": [{"entity": "tGH", "entity_type": "GENE", "pos": [154, 157]}, {"entity": "CRE - binding - protein", "entity_type": "GENE", "pos": [194, 217]}, {"entity": "activating - transcription - factor - l", "entity_type": "GENE", "pos": [220, 259]}], "task": "NER"}
{"text": "Moreover , such mutations lead to a dramatic transition in chromatin structure : the DNase I hypersensitive region is replaced by two stable , sequence - positioned nucleosomes .", "entity": [{"entity": "DNase I hypersensitive region", "entity_type": "GENE", "pos": [85, 114]}], "task": "NER"}
{"text": "Two measures of sensory inhibition were employed , S2 / S1 x 100 amplitude ratio and S1 - S2 amplitude difference .", "entity": [], "task": "NER"}
{"text": "The transcriptional start site , identified by primer extension and S1 nuclease assay , is 34 nt upstream of the translation initiation codon .", "entity": [{"entity": "S1 nuclease", "entity_type": "GENE", "pos": [68, 79]}], "task": "NER"}
{"text": "The clinical effects of valproate and ethosuximide can be related to this differential modulation of thalamocortical excitability .", "entity": [], "task": "NER"}
{"text": "Central projections of gastric afferent vagal inputs .", "entity": [], "task": "NER"}
{"text": "Our results suggest a biological role for Elf - 1 in the regulation of IgH gene expression , attribute a functional role for receptor - induced AP - 1 proteins in B lymphocytes and provide evidence for a direct link between IgM receptor - mediated signalling and 3 ' enhancer activation .", "entity": [{"entity": "Elf - 1", "entity_type": "GENE", "pos": [42, 49]}, {"entity": "IgH gene", "entity_type": "GENE", "pos": [71, 79]}, {"entity": "AP - 1 proteins", "entity_type": "GENE", "pos": [144, 159]}, {"entity": "IgM receptor", "entity_type": "GENE", "pos": [224, 236]}], "task": "NER"}
{"text": "Like Mdm2 , MdmX is able to bind p53 and inhibit p53 transactivation ; however , the ability of MdmX to degrade p53 has yet to be examined .", "entity": [{"entity": "Mdm2", "entity_type": "GENE", "pos": [5, 9]}, {"entity": "MdmX", "entity_type": "GENE", "pos": [12, 16]}, {"entity": "p53", "entity_type": "GENE", "pos": [33, 36]}, {"entity": "p53", "entity_type": "GENE", "pos": [49, 52]}, {"entity": "MdmX", "entity_type": "GENE", "pos": [96, 100]}, {"entity": "p53", "entity_type": "GENE", "pos": [112, 115]}], "task": "NER"}
{"text": "The structure of the mAR ORF was confirmed by sequence analysis of mAR cDNA fragments , which were obtained by PCR amplification of mouse testis cDNA , using mAR specific primers .", "entity": [{"entity": "mAR", "entity_type": "GENE", "pos": [21, 24]}, {"entity": "mAR", "entity_type": "GENE", "pos": [67, 70]}, {"entity": "mAR", "entity_type": "GENE", "pos": [158, 161]}], "task": "NER"}
{"text": "Transforming growth factor - beta ( TGF - beta ) inhibits cell cycle progression , in part through up - regulation of gene expression of the p21 ( WAF1 / Cip1 ) ( p21 ) cell cycle inhibitor .", "entity": [{"entity": "Transforming growth factor - beta", "entity_type": "GENE", "pos": [0, 33]}, {"entity": "TGF - beta", "entity_type": "GENE", "pos": [36, 46]}, {"entity": "p21", "entity_type": "GENE", "pos": [141, 144]}, {"entity": "WAF1", "entity_type": "GENE", "pos": [147, 151]}, {"entity": "Cip1", "entity_type": "GENE", "pos": [154, 158]}, {"entity": "p21", "entity_type": "GENE", "pos": [163, 166]}], "task": "NER"}
{"text": "Decreased plasma level of antithrombin III was assumed to be one of the major factors underlying hypercoagulable state in nephrotic syndrome .", "entity": [{"entity": "antithrombin III", "entity_type": "GENE", "pos": [26, 42]}], "task": "NER"}
{"text": "In both RAW cells and the microglia cell line EOC20 , two IFN - gamma - activated transcription factors , STAT - 1alpha and IRF - 1 , bind the GAS and IRF elements , respectively .", "entity": [{"entity": "IFN - gamma", "entity_type": "GENE", "pos": [58, 69]}, {"entity": "STAT - 1alpha", "entity_type": "GENE", "pos": [106, 119]}, {"entity": "IRF - 1", "entity_type": "GENE", "pos": [124, 131]}, {"entity": "GAS", "entity_type": "GENE", "pos": [143, 146]}, {"entity": "IRF elements", "entity_type": "GENE", "pos": [151, 163]}], "task": "NER"}
{"text": "All patients received marrow from HLA - identical sibling donors , underwent similar myeloablative regimens , and had similar pretreatment characteristics .", "entity": [{"entity": "HLA", "entity_type": "GENE", "pos": [34, 37]}], "task": "NER"}
{"text": "In Types I and II , capillary walls became thinner and more capillary lumens were visiable .", "entity": [], "task": "NER"}
{"text": "Immunoblot analyses revealed that the loss of activator function coincides with selective removal of the C - terminal domain ( CTD ) - hyperphosphorylated RNAP IIO along with NC2 .", "entity": [{"entity": "C - terminal domain ( CTD ) - hyperphosphorylated RNAP IIO", "entity_type": "GENE", "pos": [105, 163]}, {"entity": "NC2", "entity_type": "GENE", "pos": [175, 178]}], "task": "NER"}
{"text": "In bell pepper , a gene encoding a major plastid - lipid associated protein is expressed as both partially and totally spliced transcripts ( respectively PAP2 and PAP1 ) .", "entity": [{"entity": "PAP2", "entity_type": "GENE", "pos": [154, 158]}, {"entity": "PAP1", "entity_type": "GENE", "pos": [163, 167]}], "task": "NER"}
{"text": "Aggregation in washed platelets from rats with diabetes was enhanced .", "entity": [], "task": "NER"}
{"text": "Instead , the large difference in ssDNA - binding affinities reflects the loss of hexamerization ability by uvsY , suggesting that a form of intrahexamer synergism or cooperativity between binding sites within the uvsY hexamer leads to its high observed affinity for ssDNA .", "entity": [{"entity": "uvsY", "entity_type": "GENE", "pos": [108, 112]}, {"entity": "uvsY hexamer", "entity_type": "GENE", "pos": [214, 226]}], "task": "NER"}
{"text": "The authors investigate in a group of 211 children aged 2 - 6 years , incl . in particular a group of 33 2 - year - old ones , in 1990 and checked in 1991 at two sites in Bratislava - - a town with a varying concentration of NOX , SO2 , dustiness and dust fallout - - their influence on the incidence , type and course of relapsing respiratory disease .", "entity": [], "task": "NER"}
{"text": "Such results suggest that there are no differences in the BMR of age - and weight - matched Asian Indian males , other tropical populations and Americans .", "entity": [], "task": "NER"}
{"text": "CONCLUSION : DaunoXome has an improved pharmacokinetic profile compared with free daunorubicin , and is well tolerated .", "entity": [], "task": "NER"}
{"text": "Furthermore , the zincon - loaded resin was applied to the selective concentration of trace amounts of chalcophile elements in natural water samples prior to neutron activation analysis .", "entity": [], "task": "NER"}
{"text": "Analyses focused on two platyrrhine ( New World monkey ) species : the common marmoset ( Callithrix jacchus ) and the brown capuchin monkey ( Cebus apella ) , each of which has paired , non - allelic gamma loci ( 5 ' - gamma 1 - gamma 2 - 3 ' ) .", "entity": [], "task": "NER"}
{"text": "Over half of the children initially unresponsive to H . influenzae type b meningitis subsequently developed specific antibodies .", "entity": [], "task": "NER"}
{"text": "The electron spin resonance study also demonstrated that the formation of superoxide - DMPO spin adduct was strongly inhibited by a selective cyclooxygenase - 2 inhibitor , etodolac , in a concentration - dependent manner .", "entity": [{"entity": "cyclooxygenase - 2", "entity_type": "GENE", "pos": [142, 160]}], "task": "NER"}
{"text": "Sox8 maps to the t complex on mouse chromosome 17 and to human chromosome 16p13 . 3 , a region associated with the microphthalmia - cataract syndrome CATM and the alpha - thalassemia / mental retardation syndrome ATR - 16 .", "entity": [{"entity": "Sox8", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "t complex", "entity_type": "GENE", "pos": [17, 26]}], "task": "NER"}
{"text": "If vascular induction between a vascular carrier and the selected jejunal segment is done as a kind of flap prefabrication , the jejunal interposition flap can be used without the need for complex microsurgery .", "entity": [], "task": "NER"}
{"text": "There was no difference in the day - 42 cure rates between the QC7 ( n = 65 ) and A7 ( n = 64 ) regimens with an efficacy of 100 % in both , confirmed by parasite genotyping .", "entity": [], "task": "NER"}
{"text": "Acetyl - CoA carboxylase from yeast is an essential enzyme and is regulated by factors that control phospholipid metabolism .", "entity": [{"entity": "Acetyl - CoA carboxylase", "entity_type": "GENE", "pos": [0, 24]}], "task": "NER"}
{"text": "The NH ( 2 ) - terminus of all three proteins contains a POZ domain , a conserved 120 amino acid motif involved in transcriptional repression and protein dimerization .", "entity": [], "task": "NER"}
{"text": "Recognition of DNA by single - chain derivatives of the phage 434 repressor : high affinity binding depends on both the contacted and non - contacted base pairs .", "entity": [], "task": "NER"}
{"text": "In the absence of Mg2 + , the extent of destabilization of tRNAPhe is greater but appears to be confined to internal regions of the acceptor and T psi C helices , as evidenced by the selectively enhanced exchange rates for imino protons associated with these base pairs .", "entity": [{"entity": "tRNAPhe", "entity_type": "GENE", "pos": [59, 66]}], "task": "NER"}
{"text": "This gene is named PKNOX1 by the Human Nomenclature Committee .", "entity": [{"entity": "PKNOX1", "entity_type": "GENE", "pos": [19, 25]}], "task": "NER"}
{"text": "The carboxyl - terminal 75 amino acids of the two proteins contain the bHLH motif and differ from each other by only three conservative amino acid changes , while the amino - terminal portions are markedly divergent from each other .", "entity": [], "task": "NER"}
{"text": "A Drosophila subobscura genomic fragment containing all the exons and the late and early promotors in the Sxl gene of D . melanogaster was isolated .", "entity": [{"entity": "Sxl gene of D . melanogaster", "entity_type": "GENE", "pos": [106, 134]}], "task": "NER"}
{"text": "The data from animal experiments indicate that the incidence of solid tumors in marrow transplant patients may still rise in the coming decades .", "entity": [], "task": "NER"}
{"text": "The results of the transient - transfection assay showed that the Sp1 binding element located in the core region ( positions - - 64 to + 1 ) of the alpha2 - integrin promoter plays an essential role in the alpha2 - integrin promoter activity and its downregulation by Erb - B2 .", "entity": [{"entity": "Sp1 binding element", "entity_type": "GENE", "pos": [66, 85]}, {"entity": "alpha2 - integrin promoter", "entity_type": "GENE", "pos": [148, 174]}, {"entity": "alpha2 - integrin promoter", "entity_type": "GENE", "pos": [206, 232]}, {"entity": "Erb", "entity_type": "GENE", "pos": [268, 271]}, {"entity": "B2", "entity_type": "GENE", "pos": [274, 276]}], "task": "NER"}
{"text": "These observations suggest that the AF - 1 region of PPARalpha is partially silenced by corepressor proteins , which might interact in a phosphorylation - dependent manner .", "entity": [{"entity": "PPARalpha", "entity_type": "GENE", "pos": [53, 62]}], "task": "NER"}
{"text": "Evaluation of the effects of chelation therapy with time following strontium exposure to mice .", "entity": [], "task": "NER"}
{"text": "Insertion of alternatively spliced exon W into CREB mRNA during spermatogenesis results in a polycistronic RNA that encodes two novel internally translated CREB repressor isoforms called I - CREBs , consisting of the carboxy - terminal DNA - binding domain devoid of the transactivation domains .", "entity": [{"entity": "CREB mRNA", "entity_type": "GENE", "pos": [47, 56]}, {"entity": "CREB repressor isoforms", "entity_type": "GENE", "pos": [156, 179]}, {"entity": "I - CREBs", "entity_type": "GENE", "pos": [187, 196]}], "task": "NER"}
{"text": "The human BRCA1 promoter also contains a conserved E2F site and is similarly regulated by E2F1 and Rb .", "entity": [{"entity": "human BRCA1 promoter", "entity_type": "GENE", "pos": [4, 24]}, {"entity": "E2F site", "entity_type": "GENE", "pos": [51, 59]}, {"entity": "E2F1", "entity_type": "GENE", "pos": [90, 94]}, {"entity": "Rb", "entity_type": "GENE", "pos": [99, 101]}], "task": "NER"}
{"text": "In the studies described in this report , we have identified two potential Ets binding sites , EBS1 and EBS2 , which are conserved in both the human and murine interleukin - 2 enhancers .", "entity": [{"entity": "Ets", "entity_type": "GENE", "pos": [75, 78]}, {"entity": "EBS1", "entity_type": "GENE", "pos": [95, 99]}, {"entity": "EBS2", "entity_type": "GENE", "pos": [104, 108]}, {"entity": "interleukin - 2", "entity_type": "GENE", "pos": [160, 175]}], "task": "NER"}
{"text": "An enhancement of benign liver tumors ( tumorigenic effect ) was observed only in CF1 male mice ( 17 / 56 at the only tested dose : 400 ppm vs .", "entity": [], "task": "NER"}
{"text": "Stamps in cardiology : de Musset sign .", "entity": [], "task": "NER"}
{"text": "Here , we analyzed the interaction of CYT - 18 with a small RNA ( P4 - P6 RNA ) corresponding to the isolated P4 - P6 domain of the N . crassa mitochondrial large subunit ribosomal RNA intron .", "entity": [{"entity": "CYT - 18", "entity_type": "GENE", "pos": [38, 46]}, {"entity": "P4 - P6 RNA", "entity_type": "GENE", "pos": [66, 77]}, {"entity": "P4 - P6 domain", "entity_type": "GENE", "pos": [110, 124]}, {"entity": "N . crassa mitochondrial large subunit ribosomal RNA intron", "entity_type": "GENE", "pos": [132, 191]}], "task": "NER"}
{"text": "268 , 6858 - 6861 ) .", "entity": [], "task": "NER"}
{"text": "Polyglutamine - containing protein fragments have been shown to accumulate as aggregates in the nucleus and in the cytoplasm , and to induce cell death when expressed in cultured cells , leading to the proposal that polyglutamine aggregation is an important step in the pathogenesis .", "entity": [], "task": "NER"}
{"text": "We have previously shown that the transcriptional activator CREM is highly expressed in postmeiotic cells .", "entity": [{"entity": "CREM", "entity_type": "GENE", "pos": [60, 64]}], "task": "NER"}
{"text": "For more detailed mapping , we constructed mouse A9 cells containing STFs derived from human chromosome 2 tagged with pSTneo at different regions in 2q31 - qter .", "entity": [], "task": "NER"}
{"text": "We therefore propose that PRR2 , and not PVR , is the true human homolog of MPH .", "entity": [{"entity": "PRR2", "entity_type": "GENE", "pos": [26, 30]}, {"entity": "PVR", "entity_type": "GENE", "pos": [41, 44]}, {"entity": "MPH", "entity_type": "GENE", "pos": [76, 79]}], "task": "NER"}
{"text": "We have analyzed herein the roles that four different PIAS proteins ( ARIP3 / PIASx alpha , Miz1 / PIASx beta , GBP / PIAS1 , and PIAS3 ) play in the regulation of steroid receptor - or STAT - mediated transcriptional activation .", "entity": [{"entity": "PIAS proteins", "entity_type": "GENE", "pos": [54, 67]}, {"entity": "ARIP3", "entity_type": "GENE", "pos": [70, 75]}, {"entity": "PIASx alpha", "entity_type": "GENE", "pos": [78, 89]}, {"entity": "Miz1", "entity_type": "GENE", "pos": [92, 96]}, {"entity": "PIASx beta", "entity_type": "GENE", "pos": [99, 109]}, {"entity": "GBP", "entity_type": "GENE", "pos": [112, 115]}, {"entity": "PIAS1", "entity_type": "GENE", "pos": [118, 123]}, {"entity": "PIAS3", "entity_type": "GENE", "pos": [130, 135]}, {"entity": "steroid receptor", "entity_type": "GENE", "pos": [164, 180]}, {"entity": "STAT", "entity_type": "GENE", "pos": [186, 190]}], "task": "NER"}
{"text": "Yet testosterone was predominant in the plasma of the Type II male morph which neither courts females nor nests , but instead parasitizes Type I males with sneak or satellite spawning tactics .", "entity": [], "task": "NER"}
{"text": "To better understand the relationship between expression of an oncogene and genetic instability , we have studied a cell line expressing an activated human Ha - ras under the control of bacterial lactose operon regulatory elements for changes in methotrexate resistance and dihydrofolate reductase ( dhfr ) gene amplification following mutant Ha - ras induction .", "entity": [{"entity": "activated human Ha - ras", "entity_type": "GENE", "pos": [140, 164]}, {"entity": "bacterial lactose operon regulatory elements", "entity_type": "GENE", "pos": [186, 230]}, {"entity": "dihydrofolate reductase", "entity_type": "GENE", "pos": [274, 297]}, {"entity": "dhfr", "entity_type": "GENE", "pos": [300, 304]}, {"entity": "mutant Ha - ras", "entity_type": "GENE", "pos": [336, 351]}], "task": "NER"}
{"text": "Cbl is a signaling molecule with multiple functional domains : an SH2 domain which binds phosphotyrosine residues , a RING finger domain which acts as a ubiquitin ligase , a proline - rich region which serves as a docking site for SH3 - containing proteins , phosphotyrosine residues which serve as docking sites for SH2 - containing proteins such a CrkL and the p85 subunit of PI 3 - kinase , and a nuclear localization signal .", "entity": [{"entity": "Cbl", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "SH2 domain", "entity_type": "GENE", "pos": [66, 76]}, {"entity": "ubiquitin ligase", "entity_type": "GENE", "pos": [153, 169]}, {"entity": "SH3 - containing proteins", "entity_type": "GENE", "pos": [231, 256]}, {"entity": "SH2 - containing proteins", "entity_type": "GENE", "pos": [317, 342]}, {"entity": "CrkL", "entity_type": "GENE", "pos": [350, 354]}, {"entity": "p85 subunit", "entity_type": "GENE", "pos": [363, 374]}, {"entity": "PI 3 - kinase", "entity_type": "GENE", "pos": [378, 391]}], "task": "NER"}
{"text": "No interaction with epidural anesthesia was observed .", "entity": [], "task": "NER"}
{"text": "Region I includes the two cysteine - cysteine zinc fingers that comprise a DNA - binding domain which typifies all members of the superfamily .", "entity": [], "task": "NER"}
{"text": "Leukocytoclasic vasculitis during treatment with low - dose captopril", "entity": [], "task": "NER"}
{"text": "In contrast to Phase III , which has a single study design - - the controlled , randomized , double - blind study - - Phase IV requires different designs for each of the many different questions .", "entity": [], "task": "NER"}
{"text": "The results suggest that both superficial and deep cortical venous drainage of the cat kidney should be considered when measuring renal renin release .", "entity": [{"entity": "renal renin", "entity_type": "GENE", "pos": [130, 141]}], "task": "NER"}
{"text": "The aim of this work was to organize chemical data in a client - server environment using Database Management System and Web fashion for the client interface .", "entity": [], "task": "NER"}
{"text": "This bound [ 3H ] iloprost with high affinity and stimulated cAMP production when exposed to agonist .", "entity": [], "task": "NER"}
{"text": "The deduced amino acid sequence exhibits 95 . 3 and 76 . 1 % identity with the CAD sequences of hamster and Squalus acanthias .", "entity": [{"entity": "CAD sequences of hamster and Squalus acanthias", "entity_type": "GENE", "pos": [79, 125]}], "task": "NER"}
{"text": "Juvenile idiopathic inflammatory myopathies : the value of magnetic resonance imaging in the detection of muscle involvement .", "entity": [], "task": "NER"}
{"text": "The methods used were the AOAC method of dilution and heating ; the addition of mercuric chloride , charcoal , and Carrez reagents at 2 different pH values ; and direct analysis of sample supernatants with no treatment ( control ) .", "entity": [], "task": "NER"}
{"text": "In src - transformed cells GAP forms heteromeric complexes , notably with a highly tyrosine phosphorylated 62 - kDa protein ( p62 ) .", "entity": [{"entity": "src", "entity_type": "GENE", "pos": [3, 6]}, {"entity": "GAP", "entity_type": "GENE", "pos": [27, 30]}, {"entity": "62 - kDa protein ( p62 )", "entity_type": "GENE", "pos": [107, 131]}], "task": "NER"}
{"text": "Genomic Southern analysis reveals 10 to 15 hybridising fragments , suggesting that maize contains a small gene family .", "entity": [], "task": "NER"}
{"text": "The signal - to - noise ratio ( SNR ) was calculated in the T2 - weighted sequence .", "entity": [], "task": "NER"}
{"text": "The MIC90 of ABK against coagulase type IV strains was rather high , 12 . 5 micrograms / ml .", "entity": [{"entity": "coagulase type IV", "entity_type": "GENE", "pos": [25, 42]}], "task": "NER"}
{"text": "A review of 156 patients younger than 40 treated at our Department between 1960 and 1991 with transitional cell carcinoma of the bladder revealed that 89 . 1 % had superficial ( Ta / T1 ) disease and the remaining 10 . 9 % presented with invasive disease .", "entity": [], "task": "NER"}
{"text": "Expression of the Asp but not the Ala gB mutation resulted in an increase in the steady - state expression of gB at the plasma membrane ( PM ) in U373 cells .", "entity": [{"entity": "gB", "entity_type": "GENE", "pos": [38, 40]}, {"entity": "gB", "entity_type": "GENE", "pos": [110, 112]}], "task": "NER"}
{"text": "Large volumes of bone marrow may be required for certain types of autologous bone marrow transplants .", "entity": [], "task": "NER"}
{"text": "These results suggest that dauricine and verapamil have a salutary effect in extracorporeal circulation .", "entity": [], "task": "NER"}
{"text": "Central - venous - catheter - related infection is readily diagnosed by comparing simultaneous quantitative cultures of blood samples obtained via the catheter and a peripheral vein .", "entity": [], "task": "NER"}
{"text": "For evaluation of the model , simulations of physiological excitation and of pathologies ( Wolff - Parkinson - White syndrome , complete AV - block , inferior wall ischaemia ) were examined .", "entity": [], "task": "NER"}
{"text": "For rotating stimuli presented to the dominant eye , this class of neurons responded best to rotation of the visual world about an axis oriented near the horizontal plane and approximately 45 degrees azimuth .", "entity": [], "task": "NER"}
{"text": "Protein kinase C transiently activated heteromeric N - methyl - D - aspartate receptor channels independent of the phosphorylatable C - terminal splice domain and of consensus phosphorylation sites .", "entity": [{"entity": "Protein kinase C", "entity_type": "GENE", "pos": [0, 16]}, {"entity": "heteromeric N - methyl - D - aspartate receptor channels", "entity_type": "GENE", "pos": [39, 95]}], "task": "NER"}
{"text": "The incidence of the variability of the free PSA / total PSA ratio on the early diagnosis of prostate cancer", "entity": [{"entity": "PSA", "entity_type": "GENE", "pos": [45, 48]}, {"entity": "PSA", "entity_type": "GENE", "pos": [57, 60]}], "task": "NER"}
{"text": "Moreover , we show that ectopic expression of the E2A protein E12 in this macrophage line results in the induction of many B lineage genes , including EBF , IL7Ralpha , lambda5 , and Rag - 1 , and the ability to induce kappa light chain in response to mitogen .", "entity": [{"entity": "E2A protein", "entity_type": "GENE", "pos": [50, 61]}, {"entity": "E12", "entity_type": "GENE", "pos": [62, 65]}, {"entity": "EBF", "entity_type": "GENE", "pos": [151, 154]}, {"entity": "IL7Ralpha", "entity_type": "GENE", "pos": [157, 166]}, {"entity": "lambda5", "entity_type": "GENE", "pos": [169, 176]}, {"entity": "Rag - 1", "entity_type": "GENE", "pos": [183, 190]}, {"entity": "kappa light chain", "entity_type": "GENE", "pos": [219, 236]}], "task": "NER"}
{"text": "A TAAATA sequence is present 26 nt upstream from the major CAP site , and within the 5 ' - flanking region there are several putative transcription factor binding sites .", "entity": [], "task": "NER"}
{"text": "OBJECTIVES : The present study tested the hypothesis that stimulating the central noradrenergic system using the new noradrenaline re - uptake inhibitor reboxetine would result in a dose - dependent enhancement of memory for emotional material in man .", "entity": [], "task": "NER"}
{"text": "Iris binding and bioavailability .", "entity": [], "task": "NER"}
{"text": "The dopamine D1 dopamine receptor antagonist SCH 23390 dose dependently ( 7 . 5 - 30 micrograms / kg s . c . ) antagonized the stimulant locomotor effect on both drugs but did not prevent their antiimmobility effect on the behavioral despair test .", "entity": [{"entity": "dopamine D1 dopamine receptor", "entity_type": "GENE", "pos": [4, 33]}], "task": "NER"}
{"text": "Neither symptoms , virions , nor viral RNA was detectable in plants inoculated with this mutant or a mutant with a frameshift mutation in the coat gene .", "entity": [{"entity": "coat gene", "entity_type": "GENE", "pos": [142, 151]}], "task": "NER"}
{"text": "Chromaffin cells transfected with a plasmid with the entire coding sequence of c - Rabphilin3a inserted in the antisense orientation inhibited secretion of co - expressed GH by approximately 30 % .", "entity": [{"entity": "c - Rabphilin3a", "entity_type": "GENE", "pos": [79, 94]}, {"entity": "GH", "entity_type": "GENE", "pos": [171, 173]}], "task": "NER"}
{"text": "A sequence - ready 3 - Mb PAC contig covering 16 breakpoints of the Wilms tumor / anirida region of human chromosome 11p13 .", "entity": [{"entity": "Wilms tumor / anirida region", "entity_type": "GENE", "pos": [68, 96]}], "task": "NER"}
{"text": "Compression of pulmonary artery and right ventricular outflow tract by aneurysm of ascending aorta .", "entity": [], "task": "NER"}
{"text": "The sulfur species could be separated within less than 4 min by CZE with a pyromellitic acid electrolyte at pH 3 . 5 to 5 . 0 .", "entity": [], "task": "NER"}
{"text": "High expression of p51A ( TAp63gamma ) in the skeletal muscle tissue drove us to investigate a differentiation - inducible myoblastic cell line which showed increased p51A expression after differentiation induction .", "entity": [{"entity": "p51A", "entity_type": "GENE", "pos": [19, 23]}, {"entity": "TAp63gamma", "entity_type": "GENE", "pos": [26, 36]}, {"entity": "p51A", "entity_type": "GENE", "pos": [167, 171]}], "task": "NER"}
{"text": "Nosographic problems", "entity": [], "task": "NER"}
{"text": "Since UmuD protein is proteolytically processed to an active form ( UmuD * ) in a RecA * - dependent fashion , and MucA shares extensive amino acid homology with UmuD , we examined whether MucA is similarly processed in the cell , using antiserum against a LacZ ' - ' MucA fusion protein .", "entity": [{"entity": "UmuD protein", "entity_type": "GENE", "pos": [6, 18]}, {"entity": "UmuD *", "entity_type": "GENE", "pos": [68, 74]}, {"entity": "RecA", "entity_type": "GENE", "pos": [82, 86]}, {"entity": "MucA", "entity_type": "GENE", "pos": [115, 119]}, {"entity": "UmuD", "entity_type": "GENE", "pos": [162, 166]}, {"entity": "MucA", "entity_type": "GENE", "pos": [189, 193]}, {"entity": "LacZ '", "entity_type": "GENE", "pos": [257, 263]}, {"entity": "' MucA", "entity_type": "GENE", "pos": [266, 272]}], "task": "NER"}
{"text": "Changes in BHR were found to correlate significantly with changes in the levels of 24 h mean SO2 , NO2 and smoke ; 48 h mean NO2 and smoke ; 24 h lag NO2 ; although the effect was only small , accounting for approximately 10 % of the variability in within - subject BHR between visits .", "entity": [], "task": "NER"}
{"text": "50 - nucleotide ) intron to AA .", "entity": [], "task": "NER"}
{"text": "Foamy viruses ( FVs ) express the Gag protein as a precursor with a molecular mass of 74 kDa ( pr74 ) from which a 70 - kDa protein ( p70 ) is cleaved by the viral protease .", "entity": [{"entity": "Gag protein", "entity_type": "GENE", "pos": [34, 45]}, {"entity": "pr74", "entity_type": "GENE", "pos": [95, 99]}, {"entity": "p70", "entity_type": "GENE", "pos": [134, 137]}], "task": "NER"}
{"text": "Identification of domains mediating transcription activation , repression , and inhibition in the paired - related homeobox protein , Prx2 ( S8 ) .", "entity": [{"entity": "paired - related homeobox protein", "entity_type": "GENE", "pos": [98, 131]}, {"entity": "Prx2", "entity_type": "GENE", "pos": [134, 138]}, {"entity": "S8", "entity_type": "GENE", "pos": [141, 143]}], "task": "NER"}
{"text": "Because of the structural similarities the new gene will be termed scERV2 from now on .", "entity": [{"entity": "scERV2", "entity_type": "GENE", "pos": [67, 73]}], "task": "NER"}
{"text": "Where the resonator has two holes , these terms should be somewhat modified : A is the combined area of the two holes , L is 16 / 3pi r ( ~ 1 . 7r ) for a simple hole in a thin - walled vessel and r is the radius of one hole ( Seto , 1971 ) .", "entity": [], "task": "NER"}
{"text": "The most distal active site in TIGA is created by excision of a 66 - bp intron .", "entity": [{"entity": "TIGA", "entity_type": "GENE", "pos": [31, 35]}], "task": "NER"}
{"text": "GeneCalling analysis was successful in detecting members of complex metabolic pathways and uncovering novel genes that were either coincidentally regulated or directly involved in such pathways .", "entity": [], "task": "NER"}
{"text": "Cerebellar functional compensation after its complete destruction by a neoplasm", "entity": [], "task": "NER"}
{"text": "Analysis of the DNA sequence upstream of the narQ gene , which encodes the second nitrate - responsive sensor - transmitter protein in Escherichia coli , revealed an open reading frame ( ORF ) whose product shows a high degree of similarity to a number of iron - sulfur proteins as well as to the beta subunit of glutamate synthase ( gltD ) of E . coli .", "entity": [{"entity": "narQ gene", "entity_type": "GENE", "pos": [45, 54]}, {"entity": "iron - sulfur proteins", "entity_type": "GENE", "pos": [256, 278]}, {"entity": "glutamate synthase", "entity_type": "GENE", "pos": [313, 331]}, {"entity": "gltD", "entity_type": "GENE", "pos": [334, 338]}], "task": "NER"}
{"text": "Thus , the antibody class switch appears to be directed by induction of accessibility , as assayed by transcription of germ line CH genes .", "entity": [{"entity": "CH", "entity_type": "GENE", "pos": [129, 131]}], "task": "NER"}
{"text": "With repetitive intermittent exercise , gradual increases in blood lactate concentration [ ( LA ] b ) occurred , whereas its rate of accumulation ( delta [ LA ] b ) decreased .", "entity": [], "task": "NER"}
{"text": "Wingless / Wnt signaling directs cell - fate choices during embryonic development .", "entity": [{"entity": "Wingless", "entity_type": "GENE", "pos": [0, 8]}, {"entity": "Wnt", "entity_type": "GENE", "pos": [11, 14]}], "task": "NER"}
{"text": "In CYP7A1 transgenic mice , livers contained approximately 3 - fold more sterol response element - binding protein - 2 mRNA .", "entity": [{"entity": "CYP7A1", "entity_type": "GENE", "pos": [3, 9]}, {"entity": "sterol response element - binding protein - 2 mRNA", "entity_type": "GENE", "pos": [73, 123]}], "task": "NER"}
{"text": "Patients with the chronic photosensitivity dermatitis with actinic reticuloid syndrome have high total serum IgE concentrations .", "entity": [{"entity": "IgE", "entity_type": "GENE", "pos": [109, 112]}], "task": "NER"}
{"text": "Furthermore , the cognate binding protein is present in both rat and human ( HeLa ) cell nuclear extracts .", "entity": [], "task": "NER"}
{"text": "The effect of stimulation of the entopeduncular nucleus ( EP ) on the jaw - opening reflex ( JOR ) was studied in the cat anesthetized with sodium pentobarbital .", "entity": [], "task": "NER"}
{"text": "We cloned the BamHI - F fragment from the left end of Ad4 in pUC13 - 1 between the SalI and BamHI sites in order to carry out the structural analysis of the E1A region of Ad4 .", "entity": [{"entity": "BamHI - F fragment", "entity_type": "GENE", "pos": [14, 32]}, {"entity": "SalI", "entity_type": "GENE", "pos": [83, 87]}, {"entity": "BamHI sites", "entity_type": "GENE", "pos": [92, 103]}, {"entity": "E1A region of Ad4", "entity_type": "GENE", "pos": [157, 174]}], "task": "NER"}
{"text": "Results of this study indicate that when amniotic fluid samples are stored frozen and strict quality control is maintained in analytic procedures , only minimal changes occur in phospholipid concentrations over 12 months .", "entity": [], "task": "NER"}
{"text": "The objective of this research was to determine if ergotamine , an ergopeptine alkaloid isolated from Neotyphodium - infected grasses and associated with toxicoses in livestock , altered plasma concentrations of reproductive hormones in follicular phase heifers and in cows given a progestin implant .", "entity": [], "task": "NER"}
{"text": "The following parameters were measured : onset time ( time interval from injection to maximal or total block ) , T125 / 75 ( time for T1 to reach 25 % or 75 % of control ) , TOF70 ( time for TOF ratio to reach 70 % of control ) , heart rate and blood pressure .", "entity": [], "task": "NER"}
{"text": "Ectopic Xbra can induce Xegr - 1 transcription by an indirect mechanism that appears to operate via primary activation of fibroblast growth factor secretion .", "entity": [{"entity": "Xbra", "entity_type": "GENE", "pos": [8, 12]}, {"entity": "Xegr - 1", "entity_type": "GENE", "pos": [24, 32]}, {"entity": "fibroblast growth factor", "entity_type": "GENE", "pos": [122, 146]}], "task": "NER"}
{"text": "A total of 10 , 763 men and 3 , 118 women has been studied , of whom 97 % and 89 % , respectively , have been traced and 36 % and 16 % have died .", "entity": [], "task": "NER"}
{"text": "The association of I - 92 with p92 , p84 , p75 , p73 , p69 , and p57 was completely reversible after treatment with the detergent deoxycholate ( DOC ) .", "entity": [{"entity": "I - 92", "entity_type": "GENE", "pos": [19, 25]}, {"entity": "p92", "entity_type": "GENE", "pos": [31, 34]}, {"entity": "p84", "entity_type": "GENE", "pos": [37, 40]}, {"entity": "p75", "entity_type": "GENE", "pos": [43, 46]}, {"entity": "p73", "entity_type": "GENE", "pos": [49, 52]}, {"entity": "p69", "entity_type": "GENE", "pos": [55, 58]}, {"entity": "p57", "entity_type": "GENE", "pos": [65, 68]}], "task": "NER"}
{"text": "Although the elevated signalling is eliminated by deletion of Ste20p ( or components downstream of Ste20p ) , the growth and morphological abnormalities of cells lacking Akr1p are not rescued by deletion of any of the known pheromone response pathway components .", "entity": [{"entity": "Ste20p", "entity_type": "GENE", "pos": [62, 68]}, {"entity": "Ste20p", "entity_type": "GENE", "pos": [99, 105]}, {"entity": "Akr1p", "entity_type": "GENE", "pos": [170, 175]}], "task": "NER"}
{"text": "2 ) Depending on the structure , certain compounds are sequestered in the cornea ( presumably the stroma ) and form a release system into the anterior aqueous .", "entity": [], "task": "NER"}
{"text": "To gain further insights into these events , the porcine G alpha i - 3 gene minimal promoter was characterized and found 67 base pairs upstream from the major transcription start site .", "entity": [{"entity": "porcine G alpha i - 3 gene minimal promoter", "entity_type": "GENE", "pos": [49, 92]}], "task": "NER"}
{"text": "Two authors , two journal titles , two drug names , and two topics of a general medical nature were retrieved under identical circumstances and conditions on the hosts DATA - STAR , DIALOG , DIMDI , and STN .", "entity": [], "task": "NER"}
{"text": "For example , the presence of two related genes , b and b ' , in the cyanobacterium suggests that its ATP synthase is a complex of nine polypeptides , and that it may have single copies of related b and b ' proteins rather than two copies of identical b subunits as found in the E . coli enzyme . 4 + off", "entity": [{"entity": "b", "entity_type": "GENE", "pos": [50, 51]}, {"entity": "b '", "entity_type": "GENE", "pos": [56, 59]}, {"entity": "ATP synthase", "entity_type": "GENE", "pos": [102, 114]}, {"entity": "b", "entity_type": "GENE", "pos": [197, 198]}, {"entity": "b ' proteins", "entity_type": "GENE", "pos": [203, 215]}, {"entity": "b subunits", "entity_type": "GENE", "pos": [252, 262]}], "task": "NER"}
{"text": "DDD ( R ) pacing with automatic mode switch in patients with paroxysmal atrial fibrillation following AV nodal ablation .", "entity": [], "task": "NER"}
{"text": "These events were only weakly stimulated by the activated PDGF alpha - receptor .", "entity": [{"entity": "activated PDGF alpha - receptor", "entity_type": "GENE", "pos": [48, 79]}], "task": "NER"}
{"text": "These results establish that the DNA fragment we have isolated contains the human gp130 promoter and that interleukin - 6 type cytokines may influence the activity of this promoter via activated STATs .", "entity": [{"entity": "human gp130 promoter", "entity_type": "GENE", "pos": [76, 96]}, {"entity": "interleukin - 6 type cytokines", "entity_type": "GENE", "pos": [106, 136]}, {"entity": "STATs", "entity_type": "GENE", "pos": [195, 200]}], "task": "NER"}
{"text": "Only 53 % of all injuries and 12 . 5 % of serious injuries involved children , and in contrast to the 1950s and early 1960s , young adults appear at greatest risk in the 1980s .", "entity": [], "task": "NER"}
{"text": "Three simple methods of detecting malnutrition on medical wards .", "entity": [], "task": "NER"}
{"text": "We also show that an internal fragment of U24 methylation guide snoRNA , encompassing the upstream antisense element and the D ' and C ' box motifs , can support the site - specific methylation of rRNA .", "entity": [{"entity": "U24 methylation guide snoRNA", "entity_type": "GENE", "pos": [42, 70]}], "task": "NER"}
{"text": "The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo .", "entity": [{"entity": "gap", "entity_type": "GENE", "pos": [4, 7]}, {"entity": "knirps", "entity_type": "GENE", "pos": [16, 22]}], "task": "NER"}
{"text": "One of them is its limited sensitivity to weak interactions , which are common in the mammalian cerebral cortex .", "entity": [], "task": "NER"}
{"text": "An infant of 8 months with congenital glaucoma and hemophilia A lost one eye due to haemorrhages after trabeculotomy in an eye hospital .", "entity": [], "task": "NER"}
{"text": "Encapsulation of sodium fluorescein for dye release studies .", "entity": [], "task": "NER"}
{"text": "Ethanol preference in strains of rats selectively bred for behavioral characteristics .", "entity": [], "task": "NER"}
{"text": "VAV and SOCS1 form a protein complex through interactions between the VAV NH ( 2 ) - terminal regulatory region and the SH2 domain of SOCS1 in a phosphotyrosine - independent manner .", "entity": [{"entity": "VAV", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "SOCS1", "entity_type": "GENE", "pos": [8, 13]}, {"entity": "VAV NH ( 2 ) - terminal regulatory region", "entity_type": "GENE", "pos": [70, 111]}, {"entity": "SH2 domain", "entity_type": "GENE", "pos": [120, 130]}, {"entity": "SOCS1", "entity_type": "GENE", "pos": [134, 139]}], "task": "NER"}
{"text": "Incubation of HeLa cell cytoplasmic extracts with a purified recombinant glutathione S - transferase - raf fusion protein in the presence of ATP released active NF - kappa B that could be detected by electrophoretic gel mobility shift assay .", "entity": [{"entity": "glutathione S - transferase", "entity_type": "GENE", "pos": [73, 100]}, {"entity": "raf", "entity_type": "GENE", "pos": [103, 106]}, {"entity": "NF - kappa B", "entity_type": "GENE", "pos": [161, 173]}], "task": "NER"}
{"text": "Cefminox shows greater in vivo activity than that expected for the MICs , excellent efficacy and safety .", "entity": [], "task": "NER"}
{"text": "Both the p38 kinase inhibitor SB205380 ( SB ) and cotransfection of a dominant - negative mutant of p38 kinase reduced IL - 1beta stimulation of the hBNP promoter .", "entity": [{"entity": "p38 kinase", "entity_type": "GENE", "pos": [9, 19]}, {"entity": "p38 kinase", "entity_type": "GENE", "pos": [100, 110]}, {"entity": "IL - 1beta", "entity_type": "GENE", "pos": [119, 129]}, {"entity": "hBNP promoter", "entity_type": "GENE", "pos": [149, 162]}], "task": "NER"}
{"text": "Recent geological studies focusing on the Davie Fracture Zone of the Mozambique Channel offer a resolution to this situation , by suggesting the presence of a land - bridge from the mid - Eocene to the early Miocene , an interval that matches the ages of Madagascar ' s mammalian groups .", "entity": [], "task": "NER"}
{"text": "We have previously demonstrated that pyrene in diesel - exhaust particles ( DEP ) has an adjuvant activity on immunoglobulin E ( IgE ) antibody production in mice immunized with Japanese cedar pollen allergen ( JCPA ) or ovalbumin ( OA ) intraperitoneally .", "entity": [{"entity": "immunoglobulin E", "entity_type": "GENE", "pos": [110, 126]}, {"entity": "IgE", "entity_type": "GENE", "pos": [129, 132]}, {"entity": "ovalbumin", "entity_type": "GENE", "pos": [221, 230]}, {"entity": "OA", "entity_type": "GENE", "pos": [233, 235]}], "task": "NER"}
{"text": "On the basis of 8 cases , the authors report different clinical pictures all caused by cardiac toxicity of 5FU .", "entity": [], "task": "NER"}
{"text": "The immunoprofile of 60 adult patients of pulmonary tuberculosis was studied and compared with 22 normal controls .", "entity": [], "task": "NER"}
{"text": "Effects of long - term use of raloxifene , a selective estrogen receptor modulator , on thyroid function test profiles .", "entity": [{"entity": "estrogen receptor", "entity_type": "GENE", "pos": [55, 72]}], "task": "NER"}
{"text": "Module 2 of RifA lacks a beta - ketoacyl : acyl carrier protein reductase ( KR ) domain and the one in module 3 has an apparently inactive NADPH binding motif , similar to one found in the Er PKS , while the other eight KR domains of the Rf PKS should be functional .", "entity": [{"entity": "RifA", "entity_type": "GENE", "pos": [12, 16]}, {"entity": "beta - ketoacyl : acyl carrier protein reductase", "entity_type": "GENE", "pos": [25, 73]}, {"entity": "KR", "entity_type": "GENE", "pos": [76, 78]}, {"entity": "NADPH binding motif", "entity_type": "GENE", "pos": [139, 158]}, {"entity": "Er PKS", "entity_type": "GENE", "pos": [189, 195]}, {"entity": "KR domains", "entity_type": "GENE", "pos": [220, 230]}, {"entity": "Rf PKS", "entity_type": "GENE", "pos": [238, 244]}], "task": "NER"}
{"text": "Synergy between interferon - gamma and tumor necrosis factor - alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB .", "entity": [{"entity": "interferon - gamma", "entity_type": "GENE", "pos": [16, 34]}, {"entity": "tumor necrosis factor - alpha", "entity_type": "GENE", "pos": [39, 68]}, {"entity": "signal transducer and activator of transcription 1", "entity_type": "GENE", "pos": [134, 184]}, {"entity": "nuclear factor kappaB", "entity_type": "GENE", "pos": [189, 210]}], "task": "NER"}
{"text": "The corresponding tetrapeptide sequences SSPD and SATD for human and mouse PKC - epsilon , respectively , are unusual for caspase - 3 .", "entity": [{"entity": "human and mouse PKC - epsilon", "entity_type": "GENE", "pos": [59, 88]}, {"entity": "caspase - 3", "entity_type": "GENE", "pos": [122, 133]}], "task": "NER"}
{"text": "The effect of pneumoperitoneum on dissemination and scar implantation of intra - abdominal tumor cells .", "entity": [], "task": "NER"}
{"text": "CONCLUSIONS : In the results of this study , SDB , even snoring , was independently associated with hypertension in both men and women .", "entity": [], "task": "NER"}
{"text": "A poly ( ortho ester ) designed for combined ocular delivery of dexamethasone sodium phosphate and 5 - fluorouracil : subconjunctival tolerance and in vitro release .", "entity": [], "task": "NER"}
{"text": "Subclones stably expressing alpha1A - , alpha1B - , and alpha1D - ARs under control of an inducible promoter , or at high and low receptor density , were isolated and characterized .", "entity": [{"entity": "alpha1A", "entity_type": "GENE", "pos": [28, 35]}, {"entity": "alpha1B", "entity_type": "GENE", "pos": [40, 47]}, {"entity": "alpha1D", "entity_type": "GENE", "pos": [56, 63]}], "task": "NER"}
{"text": "Transfection of both Calu - 6 and JEG - 3 cells with a PKA expression vector resulted in a 10 - fold induction of human renin transcriptional activity in constructs containing the native or consensus CRE and 5 - fold activation in a construct containing a nonfunctional CRE .", "entity": [{"entity": "PKA", "entity_type": "GENE", "pos": [55, 58]}, {"entity": "human renin", "entity_type": "GENE", "pos": [114, 125]}], "task": "NER"}
{"text": "In renal vein thrombosis , similar pattern to acute tubular necrosis was found but RI venography was helpful .", "entity": [], "task": "NER"}
{"text": "Restricted expression of a novel murine atonal - related bHLH protein in undifferentiated neural precursors .", "entity": [{"entity": "murine atonal - related bHLH protein", "entity_type": "GENE", "pos": [33, 69]}], "task": "NER"}
{"text": "Oligo - [ alpha ] - deoxynucleotides can be derived by stabilizing ( intercalating ) agents or reactive groups ( cleaving reagents , cross - linkers . . . ) .", "entity": [], "task": "NER"}
{"text": "Electronic structure of Si ( 111 ) - NiSi2 ( 111 ) A - type and B - type interfaces .", "entity": [], "task": "NER"}
{"text": "In addition , two cis - acting elements direct the first zygotic expression of Kr in a striped subpattern within the central region of the blastoderm embryo .", "entity": [{"entity": "Kr", "entity_type": "GENE", "pos": [79, 81]}], "task": "NER"}
{"text": "Embryonal mortality", "entity": [], "task": "NER"}
{"text": "Regardless of muscle tensioning or marination treatments , aging of the carcass for 24 h ( T1 , T2 , and T3 ) produced meats with lower shear values than those from hot - boned carcasses ( T4 and T5 ) .", "entity": [], "task": "NER"}
{"text": "This effect was stronger after multiple predoses of sertraline , when imipramine Cmax and AUC ( 0 - infinity ) were increased by 39 % and 68 % , respectively .", "entity": [], "task": "NER"}
{"text": "For capsules containing only the drug , the value of T50 increased as the particle size of the drug decreased .", "entity": [], "task": "NER"}
{"text": "Its prognostic impact is superior to the T1 / 2 one ( RR = 2 . 9 ; p = 0 . 0010 ) .", "entity": [], "task": "NER"}
{"text": "We also show that in fusions with the DNA binding domain of GAL4 , full activity requires the entire BHV - alpha TIF , although both amino and carboxyl termini display some activity on their own .", "entity": [{"entity": "GAL4", "entity_type": "GENE", "pos": [60, 64]}, {"entity": "BHV - alpha TIF", "entity_type": "GENE", "pos": [101, 116]}], "task": "NER"}
{"text": "As well , variation in capillary size and density was apparent between ventricles in the fetal and neonatal periods .", "entity": [], "task": "NER"}
{"text": "Previous studies have demonstrated that the 21 - or the 72 - bp repeat transcriptional control elements enhance the efficiency of SV40 DNA replication in vivo , provided either of these repeats is located near the end of the core replication origin containing the 17 - bp A + T - containing sequence .", "entity": [], "task": "NER"}
{"text": "It is pathogenetically proved to use antithrombin III concentrate preparations with anti - and dysaggregatory properties , fibronectin preparations , trasylol or its analogs during complex preoperative preparation of patients .", "entity": [{"entity": "antithrombin III", "entity_type": "GENE", "pos": [37, 53]}, {"entity": "fibronectin", "entity_type": "GENE", "pos": [123, 134]}], "task": "NER"}
{"text": "ER and DR were significantly correlated with MIB - 1 LI ( P < 0 . 01 and P < 0 . 05 , respectively ) , but RI and Td / Te were not .", "entity": [{"entity": "MIB - 1", "entity_type": "GENE", "pos": [45, 52]}], "task": "NER"}
{"text": "D . , and Long , C .", "entity": [], "task": "NER"}
{"text": "A lead phthalocyanin method for the demonstration of acid hydrolases in plant and animal tissues .", "entity": [{"entity": "acid hydrolases", "entity_type": "GENE", "pos": [53, 68]}], "task": "NER"}
{"text": "On the sixth postirradiation day the absorption of phenobarbitone , sulphafurazole and mecamylamine had returned to the control level , but the absorption of quinidine and isoniazid was still retarded .", "entity": [], "task": "NER"}
{"text": "Here , we describe the three - dimensional structure of the enzyme from Escherichia colidetermined and refined to 2 . 0 A resolution .", "entity": [], "task": "NER"}
{"text": "cDNA cloning , sequencing and chromosome mapping of a non - erythroid spectrin , human alpha - fodrin .", "entity": [{"entity": "non - erythroid spectrin", "entity_type": "GENE", "pos": [54, 78]}, {"entity": "human alpha - fodrin", "entity_type": "GENE", "pos": [81, 101]}], "task": "NER"}
{"text": "In serial recall from short - term memory , repeated items are recalled well when close together ( repetition facilitation ) , but not when far apart ( repetition inhibition ; the Ranschburg effect ) .", "entity": [], "task": "NER"}
{"text": "Posterior osteophytes around the posterior edges of vertebral body resulted in intervertebral insufficiency , and corresponded to hypertrophic spur in osteochondrosis .", "entity": [], "task": "NER"}
{"text": "LV compliance was determined from the slope of the LV end - diastolic pressure ( LVEDP ) vs .", "entity": [], "task": "NER"}
{"text": "There was no significant correlation between serum amiodarone or desethylamiodarone levels and dosage of amiodarone .", "entity": [], "task": "NER"}
{"text": "Nuclear extracts from Sertoli cells were found to cause an E - box gel shift when the cells were stimulated to differentiate in culture , but not under basal conditions .", "entity": [], "task": "NER"}
{"text": "The combination of ICP47 and US11 rendered fibroblasts negative for surface class I MHC and allowed a class I MHC - low population of T cells to be sorted by flow cytometry .", "entity": [{"entity": "ICP47", "entity_type": "GENE", "pos": [19, 24]}, {"entity": "US11", "entity_type": "GENE", "pos": [29, 33]}, {"entity": "surface class I MHC", "entity_type": "GENE", "pos": [68, 87]}, {"entity": "class I MHC", "entity_type": "GENE", "pos": [102, 113]}], "task": "NER"}
{"text": "The recovery of adults schistosomes by extracorporeal filtration .", "entity": [], "task": "NER"}
{"text": "Biochemical studies and studies of cells expressing mutant IL - 2 receptors indicate that IL - 2 - induced tyrosine kinase activation initiates a complex signaling cascade .", "entity": [{"entity": "IL - 2 receptors", "entity_type": "GENE", "pos": [59, 75]}, {"entity": "IL - 2", "entity_type": "GENE", "pos": [90, 96]}, {"entity": "tyrosine kinase", "entity_type": "GENE", "pos": [107, 122]}], "task": "NER"}
{"text": "Serum levels of angiotensin converting enzyme were well maintained .", "entity": [{"entity": "angiotensin converting enzyme", "entity_type": "GENE", "pos": [16, 45]}], "task": "NER"}
{"text": "We tested the effects of antifungal drugs on adherence of Candida albicans in vitro .", "entity": [], "task": "NER"}
{"text": "The sections were stained with anti - polymorphonuclear leukocyte antibody , the endothelial marker factor VIII - related antigen , and with hematoxylin and eosin .", "entity": [{"entity": "factor VIII - related antigen", "entity_type": "GENE", "pos": [100, 129]}], "task": "NER"}
{"text": "Portions of the 3 ' - coding and 3 ' - untranslated regions were found to be missing from the 7 . 2 - and 4 . 8 - kb topo II alpha mRNAs by Northern blot analysis .", "entity": [{"entity": "7 . 2 - and 4 . 8 - kb topo II alpha mRNAs", "entity_type": "GENE", "pos": [94, 136]}], "task": "NER"}
{"text": "The combined in vitro effects of ethanol wih methaqualone , phenobarbital , pyrazole or disulfiram were studied using rat brain microsomal NA - K - ATPase .", "entity": [{"entity": "rat brain microsomal NA - K - ATPase", "entity_type": "GENE", "pos": [118, 154]}], "task": "NER"}
{"text": "An analogue of calcium , strontium chloride Sr 89 is rapidly cleared from the blood after i . v . injection .", "entity": [], "task": "NER"}
{"text": "These mutants , assayed by injection into Xenopus oocyte nuclei , delimit the promoter to 36 bp of DNA upstream of the cap site and 73 bp of the untranslated mRNA leader .", "entity": [], "task": "NER"}
{"text": "The ARE is loosely defined as the five - nucleotide sequence AUUUA embedded in a uracil - rich region .", "entity": [], "task": "NER"}
{"text": "The essential oil composition of three Zingiberaceae widely used as medicinal aromatic plants from S .", "entity": [], "task": "NER"}
{"text": "( 3 ) With the exception of the anteroposterior direction of layers II - - III and the mediolateral direction of layer IV , the vertical conductivity of the cortex was always greater than either of the horizontal conductivities .", "entity": [], "task": "NER"}
{"text": "Acad .", "entity": [], "task": "NER"}
{"text": "To obtain information on the functional role of the Rac1 / p38 / MAPKAPK - 2 pathway in RA signaling , the effects of pharmacological inhibition of p38 on RA - induced gene transcription and cell differentiation were determined .", "entity": [{"entity": "Rac1", "entity_type": "GENE", "pos": [52, 56]}, {"entity": "p38", "entity_type": "GENE", "pos": [59, 62]}, {"entity": "MAPKAPK - 2", "entity_type": "GENE", "pos": [65, 76]}, {"entity": "p38", "entity_type": "GENE", "pos": [148, 151]}], "task": "NER"}
{"text": "A regulatory element of the empty spiracles homeobox gene is composed of three distinct conserved regions that bind regulatory proteins .", "entity": [{"entity": "empty spiracles", "entity_type": "GENE", "pos": [28, 43]}], "task": "NER"}
{"text": "CONCLUSIONS : The MC / UA ratio improves the sensitivity for the prediction of poor perinatal outcome when it is combined with the NST .", "entity": [], "task": "NER"}
{"text": "Together with previous work our results suggest that C / EBP may be a general cooperation partner for v - Myb in myelomonocytic cells .", "entity": [{"entity": "C / EBP", "entity_type": "GENE", "pos": [53, 60]}, {"entity": "v - Myb", "entity_type": "GENE", "pos": [102, 109]}], "task": "NER"}
{"text": "Evolution of cytomegalovirus antibodies of maternal origin and acquired , throughout the first year of life", "entity": [], "task": "NER"}
{"text": "IENF density at the calf was lower than that obtained from skin at more proximal sites , indicating the length dependency of small - fiber loss in these neuropathies .", "entity": [], "task": "NER"}
{"text": "The sequence contained five repeats of the hypothetical leucine zipper motif : one is in the N - terminal globular domain , and four are in the central alpha - helical stalk .", "entity": [], "task": "NER"}
{"text": "This paper reports estimates of the prevalence of mental retardation and associated factors based on a population survey of 2 - to 9 - year - old children in Greater Karachi , Pakistan .", "entity": [], "task": "NER"}
{"text": "Zta stimulated the HAT activity of CBP that had been partially purified or immunoprecipitated from mammalian cells as well as from affinity - purified , baculovirus expressed CBP .", "entity": [{"entity": "Zta", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "HAT", "entity_type": "GENE", "pos": [19, 22]}, {"entity": "CBP", "entity_type": "GENE", "pos": [35, 38]}, {"entity": "CBP", "entity_type": "GENE", "pos": [175, 178]}], "task": "NER"}
{"text": "Previous studies using partial sequences have suggested the potential of 26S or large - subunit ( LSU ) rDNA for phylogeny retrieval at taxonomic levels comparable to those investigated with 18S rDNA .", "entity": [{"entity": "26S", "entity_type": "GENE", "pos": [73, 76]}, {"entity": "large - subunit", "entity_type": "GENE", "pos": [80, 95]}, {"entity": "LSU", "entity_type": "GENE", "pos": [98, 101]}, {"entity": "18S rDNA", "entity_type": "GENE", "pos": [191, 199]}], "task": "NER"}
{"text": "P53 mutations also offer new approaches to the study of the origins of mutations in human cancer .", "entity": [{"entity": "P53 mutations", "entity_type": "GENE", "pos": [0, 13]}], "task": "NER"}
{"text": "Due to significant homology to the C - terminus of the Mutator transposase this alternative gene product was named Trap ( transposon - associated protein ) .", "entity": [{"entity": "Mutator transposase", "entity_type": "GENE", "pos": [55, 74]}, {"entity": "Trap", "entity_type": "GENE", "pos": [115, 119]}, {"entity": "transposon - associated protein", "entity_type": "GENE", "pos": [122, 153]}], "task": "NER"}
{"text": "RT - PCR analysis of FGFR - 3 mRNA showed the presence of a splice variant in which exons 7 and 8 are deleted .", "entity": [{"entity": "FGFR - 3 mRNA", "entity_type": "GENE", "pos": [21, 34]}], "task": "NER"}
{"text": "A novel serine kinase activated by rac1 / CDC42Hs - dependent autophosphorylation is related to PAK65 and STE20 .", "entity": [{"entity": "serine kinase", "entity_type": "GENE", "pos": [8, 21]}, {"entity": "rac1", "entity_type": "GENE", "pos": [35, 39]}, {"entity": "CDC42Hs", "entity_type": "GENE", "pos": [42, 49]}, {"entity": "PAK65", "entity_type": "GENE", "pos": [96, 101]}, {"entity": "STE20", "entity_type": "GENE", "pos": [106, 111]}], "task": "NER"}
{"text": "CYP51P1 is 96 . 5 % identical to the human CYP51 coding sequence and is not interrupted with introns but has six in - frame stop codons resulting from point mutations .", "entity": [{"entity": "CYP51P1", "entity_type": "GENE", "pos": [0, 7]}, {"entity": "human CYP51", "entity_type": "GENE", "pos": [37, 48]}], "task": "NER"}
{"text": "Patients with risk factors were compared with those without risk factors .", "entity": [], "task": "NER"}
{"text": "Mutations in glnB , nifR1 ( ntrC ) , and NifR4 ( ntrA encoding sigma 54 ) had no influence on put gene expression .", "entity": [{"entity": "glnB", "entity_type": "GENE", "pos": [13, 17]}, {"entity": "nifR1", "entity_type": "GENE", "pos": [20, 25]}, {"entity": "ntrC", "entity_type": "GENE", "pos": [28, 32]}, {"entity": "NifR4", "entity_type": "GENE", "pos": [41, 46]}, {"entity": "ntrA", "entity_type": "GENE", "pos": [49, 53]}, {"entity": "sigma 54", "entity_type": "GENE", "pos": [63, 71]}, {"entity": "put gene", "entity_type": "GENE", "pos": [94, 102]}], "task": "NER"}
{"text": "This bud morphology results at least in part from a cell cycle delay imposed by the Cdc28p - inhibitory kinase Swe1p .", "entity": [{"entity": "Cdc28p", "entity_type": "GENE", "pos": [84, 90]}, {"entity": "Swe1p", "entity_type": "GENE", "pos": [111, 116]}], "task": "NER"}
{"text": "IgE - binding proteins of Psocoptera were determined by immunoblotting experiments .", "entity": [{"entity": "IgE - binding proteins", "entity_type": "GENE", "pos": [0, 22]}], "task": "NER"}
{"text": "174 , 233 - 247 ) and Serrate ( Serrate1 and 2 ; Myat , A . , Henrique , D . , Ish - Horowicz , D . and Lewis , J . , 1996 .", "entity": [], "task": "NER"}
{"text": "A new technique for the identification of phases contained within a polymer blend is described in this paper .", "entity": [], "task": "NER"}
{"text": "Nonlethal sec71 - 1 and sec72 - 1 mutations eliminate proteins associated with the Sec63p - BiP complex from S . cerevisiae .", "entity": [{"entity": "sec71 - 1", "entity_type": "GENE", "pos": [10, 19]}, {"entity": "sec72 - 1 mutations", "entity_type": "GENE", "pos": [24, 43]}, {"entity": "Sec63p", "entity_type": "GENE", "pos": [83, 89]}, {"entity": "BiP", "entity_type": "GENE", "pos": [92, 95]}], "task": "NER"}
{"text": "Our studies indicate no single trans - acting factor is absolutely essential for enhancer activity , and that the enhancer activity of MerI is mediated via a combinatorial and additive mechanism .", "entity": [{"entity": "MerI", "entity_type": "GENE", "pos": [135, 139]}], "task": "NER"}
{"text": "We recently reported the cloning and sequencing of the alpha 7 integrin chain and its regulated expression during the development of skeletal muscle ( Song et al .", "entity": [{"entity": "alpha 7 integrin chain", "entity_type": "GENE", "pos": [55, 77]}], "task": "NER"}
{"text": "Analytical scanning isoelectrofocusing .", "entity": [], "task": "NER"}
{"text": "A structural model for Vpu is proposed in which the membrane anchor precedes a region comprising two amphipathic alpha - helices of opposed polarity , joined by a strongly acidic turn that protrudes into the cytoplasm and contains the CK - 2 phosphorylation sites .", "entity": [{"entity": "Vpu", "entity_type": "GENE", "pos": [23, 26]}, {"entity": "CK - 2 phosphorylation sites", "entity_type": "GENE", "pos": [235, 263]}], "task": "NER"}
{"text": "Primer extension analysis and subcloning of the virJ - phoA fusion indicate that the acetosyringone - inducible promoter lies directly upstream of the virJ structural gene .", "entity": [{"entity": "virJ", "entity_type": "GENE", "pos": [48, 52]}, {"entity": "phoA", "entity_type": "GENE", "pos": [55, 59]}, {"entity": "virJ structural gene", "entity_type": "GENE", "pos": [151, 171]}], "task": "NER"}
{"text": "This novel TRPC7 gene could be a candidate gene for genetic disorders such as bipolar affective disorder , nonsyndromic hereditary deafness , Knobloch syndrome , and holoprosencephaly , which were mapped to this region .", "entity": [{"entity": "TRPC7 gene", "entity_type": "GENE", "pos": [11, 21]}], "task": "NER"}
{"text": "In the future , transoesophageal echocardiography may be used to measure variations in wall thickness which change the global loading conditions in the basal midwall compartments of the left ventricle .", "entity": [], "task": "NER"}
{"text": "METHODS : A discriminant function predicting surgery outcome ( seizure - free vs . non - seizure - free ) was computed separately for samples of patients with left ( n = 79 ) and right ( n = 62 ) temporal lobectomy ( LATL , RATL ) .", "entity": [], "task": "NER"}
{"text": "A porcine model of diffuse axonal injury , developed with information from these physical models and earlier in vitro tissue modeling studies , is used to correlate histologic and radiologic evidence of axonal injury to predicted regions of injury from the experimental and theoretical analysis .", "entity": [], "task": "NER"}
{"text": "Control of ovulation in mares in the early breeding season with ovarian steroids and prostaglandin .", "entity": [], "task": "NER"}
{"text": "The aim of this study was to determine the response properties of the human visual cortex to chromatic stimuli using magnetoencephalography ( MEG ) .", "entity": [], "task": "NER"}
{"text": "By subtractive and differential screening , we have cloned 12 of these sequences , 2 of which were c - fos and krox - 24 .", "entity": [{"entity": "c - fos", "entity_type": "GENE", "pos": [99, 106]}, {"entity": "krox - 24", "entity_type": "GENE", "pos": [111, 120]}], "task": "NER"}
{"text": "Basal level expression was reduced to 20 and 50 % when the UGA stop codon was replaced by UAG or UAA , respectively , consistent with the finding that in E . coli translation terminates more efficiently at UAG and UAA than at UGA .", "entity": [], "task": "NER"}
{"text": "3 .", "entity": [], "task": "NER"}
{"text": "The root - mean - square deviation of bond lengths from the ideal values is 0 . 02 A .", "entity": [], "task": "NER"}
{"text": "Sugar analysis was performed on alpha - TM to investigate a possible biosynthetic mechanism for part - time PGs .", "entity": [{"entity": "alpha - TM", "entity_type": "GENE", "pos": [32, 42]}], "task": "NER"}
{"text": "To our knowledge no transcription factors have previously been identified that exhibit androgen - dependent expression in the epididymis .", "entity": [], "task": "NER"}
{"text": "4 .", "entity": [], "task": "NER"}
{"text": "Proceedings : Influence of halothane on mortality from murine hepatitis virus ( MHV3 ) .", "entity": [], "task": "NER"}
{"text": "Prevalence of rheumatic diseases in a rural population in western India : a WHO - ILAR COPCORD Study .", "entity": [], "task": "NER"}
{"text": "Finally , in samples obtained from two patients with drug refractory ALL , BAC - derived probes applied to archived marrow cells demonstrated that a breakpoint occurred between MDR1 and sequences 500 - 1000 KB telomeric to MDR1 , consistent with a random chromosomal rearrangement .", "entity": [{"entity": "MDR1", "entity_type": "GENE", "pos": [177, 181]}, {"entity": "MDR1", "entity_type": "GENE", "pos": [223, 227]}], "task": "NER"}
{"text": "We conclude that clonidine 3 micrograms / kg produces sedation comparable to diazepam 0 . 2 mg / kg and also attenuates the intubation response without increasing the incidence of complications .", "entity": [], "task": "NER"}
{"text": "The other regions include potential binding sites for transcription factors ATF , NF1 , and a CCAAT - binding protein .", "entity": [{"entity": "ATF", "entity_type": "GENE", "pos": [76, 79]}, {"entity": "NF1", "entity_type": "GENE", "pos": [82, 85]}, {"entity": "CCAAT - binding protein", "entity_type": "GENE", "pos": [94, 117]}], "task": "NER"}
{"text": "The analysis predicted that progressive increases in serum creatinine or aspartate transaminase activity will result in only a 50 % reduction of clearance .", "entity": [{"entity": "aspartate transaminase", "entity_type": "GENE", "pos": [73, 95]}], "task": "NER"}
{"text": "5 Intravenous prizidilol hydrochloride decreases resting blood pressure and left ventricular area , increases pulse rate and has virtually no effect on left ventricular ejection fraction .", "entity": [], "task": "NER"}
{"text": "The Saccharomyces cerevisiae targets of rapamycin , TOR1 and TOR2 , signal activation of cell growth in response to nutrient availability .", "entity": [{"entity": "TOR1", "entity_type": "GENE", "pos": [52, 56]}, {"entity": "TOR2", "entity_type": "GENE", "pos": [61, 65]}], "task": "NER"}
{"text": "This 50 - kDa protein contains two SH2 domains and an inter - SH2 domain of p85alpha , but the SH3 and bcr homology domains of p85alpha were replaced by a unique 6 - amino acid sequence .", "entity": [{"entity": "SH2 domains", "entity_type": "GENE", "pos": [35, 46]}, {"entity": "inter - SH2 domain", "entity_type": "GENE", "pos": [54, 72]}, {"entity": "p85alpha", "entity_type": "GENE", "pos": [76, 84]}, {"entity": "SH3", "entity_type": "GENE", "pos": [95, 98]}, {"entity": "bcr homology domains", "entity_type": "GENE", "pos": [103, 123]}, {"entity": "p85alpha", "entity_type": "GENE", "pos": [127, 135]}], "task": "NER"}
{"text": "Gene structure and precursor processing .", "entity": [], "task": "NER"}
{"text": "This effect is independent of the Gal4 protein , as it operates in a gal4 mutant background as well .", "entity": [{"entity": "Gal4 protein", "entity_type": "GENE", "pos": [34, 46]}, {"entity": "gal4 mutant", "entity_type": "GENE", "pos": [69, 80]}], "task": "NER"}
{"text": "Thus , d - delta3 - carene was about four times more potent as a sensory irritant than I - beta - pinene , whereas the difference with I - alpha - pinene was more marked ; as a sensory irritant , I - alpha - pinene is almost inactive .", "entity": [], "task": "NER"}
{"text": "Blood and whole - brain mercury concentrations were determined in pups on PN 0 ( birth ) and PN 21 ( weaning ) .", "entity": [], "task": "NER"}
{"text": "Multiple copies of this binding site are found in the viral genomes .", "entity": [], "task": "NER"}
{"text": "Tubular dysfunction in renal lithiasis : cause or consequence ? ] To investigate whether overall tubular dysfunction is encountered in a particular subgroup of patients with urolithiasis , the following parameters of renal tubular function have been measured in fasting morning urine in 124 male stone formers : excretion of lysozyme and gamma - glutamyl transpeptidase ( gamma - GT ) , fractional excretion ( FE ) or glucose , insulin , bicarbonate after an alkali load , and theoretical phosphate threshold ( TmP / GFR ) .", "entity": [{"entity": "lysozyme", "entity_type": "GENE", "pos": [325, 333]}, {"entity": "gamma - glutamyl transpeptidase", "entity_type": "GENE", "pos": [338, 369]}, {"entity": "gamma - GT", "entity_type": "GENE", "pos": [372, 382]}, {"entity": "insulin", "entity_type": "GENE", "pos": [428, 435]}], "task": "NER"}
{"text": "The blood pressures in 43 subjects were compared during rapid weight loss and at identical weights during post - fast weight gain ( Study A ) .", "entity": [], "task": "NER"}
{"text": "Mol .", "entity": [], "task": "NER"}
{"text": "Arg - 130 , Gly - 132 and Lys - 167 are conserved in all members of the type IB topoisomerase family .", "entity": [{"entity": "type IB topoisomerase family", "entity_type": "GENE", "pos": [72, 100]}], "task": "NER"}
{"text": "The maximal rise in plasma adrenaline was of similar magnitude in all three groups but a lower plasma glucose was required to stimulate this hormonal response in the ' unaware ' patients , in whom the plasma adrenaline concentration was lower at the time of the reaction .", "entity": [], "task": "NER"}
{"text": "PATIENTS - - 125 women consulting the general practitioner for symptomatic bacterial vaginosis .", "entity": [], "task": "NER"}
{"text": "Patients with advanced ovarian carcinoma , Stage III or IV ( International Federation of Gynaecology and Obstetrics ) , were randomized to primary chemotherapy with doxorubicin ( Adriamycin ) and cisplatin plus or minus hexamethylmelamine , and cyclophosphamide ( CHAP ) .", "entity": [], "task": "NER"}
{"text": "Promoter activity of the proliferating - cell nuclear antigen gene is associated with inducible CRE - binding proteins in interleukin 2 - stimulated T lymphocytes .", "entity": [{"entity": "proliferating - cell nuclear antigen gene", "entity_type": "GENE", "pos": [25, 66]}, {"entity": "CRE - binding proteins", "entity_type": "GENE", "pos": [96, 118]}, {"entity": "interleukin 2", "entity_type": "GENE", "pos": [122, 135]}], "task": "NER"}
{"text": "Sequence analysis revealed 100 % homology of all RA - derived PTEN fragments to those from normal SF as well as to the published GenBank sequence ( accession number U93051 ) .", "entity": [{"entity": "PTEN fragments", "entity_type": "GENE", "pos": [62, 76]}, {"entity": "U93051", "entity_type": "GENE", "pos": [165, 171]}], "task": "NER"}
{"text": "The mutation also preferentially limits ( compared with total protein synthesis ) translation of an induced gene that depends on five AGA codons , i . e . , the lambda cI repressor gene .", "entity": [{"entity": "lambda cI repressor gene", "entity_type": "GENE", "pos": [161, 185]}], "task": "NER"}
{"text": "The influence of a high n - 3 PUFA intake on measures of lipid peroxidation has been equivocal .", "entity": [], "task": "NER"}
{"text": "In contrast , inhibition of MAPK activity by MAPK kinase inhibitor ( PD 98059 ) or by overexpression of kinase - deficient MAPKs activated basal and GnRH - A - stimulated GnRHR - Luc activity .", "entity": [{"entity": "MAPK", "entity_type": "GENE", "pos": [28, 32]}, {"entity": "MAPK kinase", "entity_type": "GENE", "pos": [45, 56]}, {"entity": "MAPKs", "entity_type": "GENE", "pos": [123, 128]}, {"entity": "GnRH - A", "entity_type": "GENE", "pos": [149, 157]}, {"entity": "GnRHR", "entity_type": "GENE", "pos": [171, 176]}, {"entity": "Luc", "entity_type": "GENE", "pos": [179, 182]}], "task": "NER"}
{"text": "For the first , short - term ( concurrent ) TAL , two different - flavored stimuli were presented at the same time , one associated with simultaneous intragastric administration of an aversive product , hypertonic NaCl , and the other with saline .", "entity": [], "task": "NER"}
{"text": "CONCLUSIONS : LHB is simple , easy and safe to implement , and is the only technique capable of maintaining independent upper and lower body perfusion pressure .", "entity": [], "task": "NER"}
{"text": "Heterodimerization mutant RXR failed to alter GFP - VDR and nlsGFP - VDR distribution or activity .", "entity": [{"entity": "Heterodimerization mutant RXR", "entity_type": "GENE", "pos": [0, 29]}, {"entity": "GFP", "entity_type": "GENE", "pos": [46, 49]}, {"entity": "VDR", "entity_type": "GENE", "pos": [52, 55]}, {"entity": "nlsGFP", "entity_type": "GENE", "pos": [60, 66]}, {"entity": "VDR", "entity_type": "GENE", "pos": [69, 72]}], "task": "NER"}
{"text": "New TB respirator standards mean more choices at less cost .", "entity": [], "task": "NER"}
{"text": "After first strand cDNA synthesis from fetal brain mRNAs , short fragment cDNAs ( sf - cDNAs ) were synthesized with a two - step amplification system by use of our modified Degenerate Oligonucleotide Primed Shuttle Polymerase Chain Reaction ( DOP - Shuttle - PCR ) method .", "entity": [], "task": "NER"}
{"text": "Fulminant hepatic failure in these cases could be characterized by : ( 1 ) rapid decrease in serum alanine transaminase ( ALT ) level after discontinuation of ecarazine , ( 2 ) prolonged jaundice despite discontinuation of ecarazine , ( 3 ) high incidence of anti - nuclear antibody ( ANA ) ( 57 % ) , and ( 4 ) histological findings of extensive hepatocellular necrosis ranging from bridging necrosis to massive necrosis .", "entity": [{"entity": "serum alanine transaminase", "entity_type": "GENE", "pos": [93, 119]}, {"entity": "ALT", "entity_type": "GENE", "pos": [122, 125]}, {"entity": "anti - nuclear antibody", "entity_type": "GENE", "pos": [259, 282]}, {"entity": "ANA", "entity_type": "GENE", "pos": [285, 288]}], "task": "NER"}
{"text": "Smectic - A ordering at a liquid - vapor interface .", "entity": [], "task": "NER"}
{"text": "Simulation results based on the presented model are compared with the experimental data for two types of cMUTs reported in the recent literature .", "entity": [], "task": "NER"}
{"text": "These results demonstrate that the entire E3L gene is required for pathogenesis in the mouse model .", "entity": [{"entity": "E3L gene", "entity_type": "GENE", "pos": [42, 50]}], "task": "NER"}
{"text": "Parelaphostrongylus odocoilei is redescribed from worms collected from the type host ( Odocoileus hemionus columbianus ) in California , as well as material from experimentally infected mule deer ( O . h . heminus ) in Alberta .", "entity": [], "task": "NER"}
{"text": "Sodium dodecylsulfate polyacrylamide gel electrophoresis ( SDS - PAGE ) showed two bands of about the same intensity with apparent molecular masses of 24 . 5 and 22 . 5 kDa .", "entity": [], "task": "NER"}
{"text": "Particle bombardment of barley aleurone with a B22EL8 promoter - GUS ( beta - glucuronidase ) construct demonstrates that the promoter ( 3 kb ) is active in developing barley grains .", "entity": [{"entity": "B22EL8 promoter", "entity_type": "GENE", "pos": [47, 62]}, {"entity": "GUS", "entity_type": "GENE", "pos": [65, 68]}, {"entity": "beta - glucuronidase", "entity_type": "GENE", "pos": [71, 91]}], "task": "NER"}
{"text": "The cloning of CWH43 showed that it corresponds to YCR017c and encodes a protein with 14 - 16 transmembrane segments containing several putative phosphorylation and glycosylation sites .", "entity": [{"entity": "CWH43", "entity_type": "GENE", "pos": [15, 20]}, {"entity": "YCR017c", "entity_type": "GENE", "pos": [51, 58]}], "task": "NER"}
{"text": "They elicit similar regional cerebral blood flow ( rCBF ) patterns , even though sign language is dependent on spatial information .", "entity": [], "task": "NER"}
{"text": "However , at the time of salvage treatment , the mean serum PSA levels were 9 . 1 and 1 . 1 ng / mL for the salvage RP and salvage RT groups , respectively ( P = 0 . 0001 ) .", "entity": [{"entity": "serum PSA", "entity_type": "GENE", "pos": [54, 63]}], "task": "NER"}
{"text": "First , a GATA - 1 motif was found to bind nuclear factor ( s ) , presumably the GATA - 1 factor , present in K - 562 cell extracts and in living K - 562 cells .", "entity": [{"entity": "GATA - 1 motif", "entity_type": "GENE", "pos": [10, 24]}, {"entity": "GATA - 1 factor", "entity_type": "GENE", "pos": [81, 96]}], "task": "NER"}
{"text": "There was a direct proportional relationship between the spiral artery flow and the pressure difference between the spiral artery and the amniotic fluid ; the pressure difference per flow ( the resistance of the cotyledonary unit ) was found to be 1 - - 3 mm Hg . ml - 1 . min ( 8 - - 24kPa . ml - 1 . s ) .", "entity": [], "task": "NER"}
{"text": "Truncations from Hip ' s N terminus resulted in an apparent loss of Hip homo - oligomerization , but these mutants retained association with hsp70 and were recovered in receptor complexes .", "entity": [{"entity": "Hip", "entity_type": "GENE", "pos": [17, 20]}, {"entity": "Hip", "entity_type": "GENE", "pos": [68, 71]}, {"entity": "hsp70", "entity_type": "GENE", "pos": [141, 146]}], "task": "NER"}
{"text": "An oligomer synthesized to this region of homology produced two DNA - protein complexes with oviduct nuclear proteins .", "entity": [], "task": "NER"}
{"text": "The myeloid zinc finger gene 1 ( MZF1 ) encodes a C ( 2 ) H ( 2 ) zinc finger transcription factor that regulates granulopoiesis and may have a regulatory role in cellular proliferation and oncogenesis .", "entity": [{"entity": "myeloid zinc finger gene 1", "entity_type": "GENE", "pos": [4, 30]}, {"entity": "MZF1", "entity_type": "GENE", "pos": [33, 37]}, {"entity": "C ( 2 ) H ( 2 ) zinc finger transcription factor", "entity_type": "GENE", "pos": [50, 98]}], "task": "NER"}
{"text": "The rate of collagen synthesis in normal scar was approximately constant between 6 months and 20 years after the initial wounding , but in both hypertrophic scar and keloid the rate was initially approximately twice that in normal scar , and 2 - 3 years after wounding it fell to approximately the same level as in normal scar .", "entity": [{"entity": "collagen", "entity_type": "GENE", "pos": [12, 20]}], "task": "NER"}
{"text": "When phentermine was mixed with other unlabeled reversible MAO inhibitors ( e . g . pseudoephedrine , ephedrine , norephedrine ; estradiol benzoate ) , the degree of MAO inhibition was additive .", "entity": [{"entity": "MAO", "entity_type": "GENE", "pos": [59, 62]}, {"entity": "MAO", "entity_type": "GENE", "pos": [166, 169]}], "task": "NER"}
{"text": "W . , and Touster , O .", "entity": [], "task": "NER"}
{"text": "There was a 57 % reduction in IGF IR mRNA levels in clone CA9 after confluence compared with clone ME10 .", "entity": [{"entity": "IGF IR mRNA", "entity_type": "GENE", "pos": [30, 41]}], "task": "NER"}
{"text": "Uncoupling gene activity from chromatin structure : promoter mutations can inactivate transcription of the yeast HSP82 gene without eliminating nucleosome - free regions .", "entity": [{"entity": "yeast HSP82 gene", "entity_type": "GENE", "pos": [107, 123]}], "task": "NER"}
{"text": "Heating had no effect upon either force decline or slowing of relaxation during fatiguing contractions .", "entity": [], "task": "NER"}
{"text": "Uncertainty exists about the function of these potential isoforms of the Cbfa1 gene .", "entity": [{"entity": "Cbfa1 gene", "entity_type": "GENE", "pos": [73, 83]}], "task": "NER"}
{"text": "The RTI40 gene spans 35 kilobase pairs ; it contains 6 exons and at least 6 rat Identifier repetitive elements .", "entity": [{"entity": "RTI40 gene", "entity_type": "GENE", "pos": [4, 14]}], "task": "NER"}
{"text": "The characteristics of a simple apparatus for clinical use to measure DEOAEs are described together with typical examples of emissions .", "entity": [], "task": "NER"}
{"text": "Anatomical considerations in transsphenoidal hypophysectomy .", "entity": [], "task": "NER"}
{"text": "It has been confirmed in animal experiments that the number of microspheres in a myocardial sample approximately follows a Poisson distribution , under adequate experimental conditions .", "entity": [], "task": "NER"}
{"text": "Maximal exercise duration and peak oxygen consumption were not changed .", "entity": [], "task": "NER"}
{"text": "Hard methacrylic polymers .", "entity": [], "task": "NER"}
{"text": "Validity of the short - form QIF was assessed by correlation with motor scores and using analysis of variance by motor levels and motor score groupings .", "entity": [], "task": "NER"}
{"text": "An 81 - nt tandem duplication of the C - terminal coding region is located adjacent to the termination codon of the CyIIIb gene , a potential relic of a slipped mispairing and replication event .", "entity": [{"entity": "CyIIIb gene", "entity_type": "GENE", "pos": [116, 127]}], "task": "NER"}
{"text": "During seed maturation , the transcriptional activity of napin genes is regulated by developmental signals involving the transcriptional activator ABI3 and abscisic acid ( ABA ) .", "entity": [{"entity": "napin genes", "entity_type": "GENE", "pos": [57, 68]}, {"entity": "transcriptional activator ABI3", "entity_type": "GENE", "pos": [121, 151]}], "task": "NER"}
{"text": "Here we report the cloning , by either peptide sequencing or by sequence similarity to the human cDNAs , of the S . cerevisiae genes RFC1 , RFC2 , RFC3 , RFC4 , and RFC5 .", "entity": [{"entity": "RFC1", "entity_type": "GENE", "pos": [133, 137]}, {"entity": "RFC2", "entity_type": "GENE", "pos": [140, 144]}, {"entity": "RFC3", "entity_type": "GENE", "pos": [147, 151]}, {"entity": "RFC4", "entity_type": "GENE", "pos": [154, 158]}, {"entity": "RFC5", "entity_type": "GENE", "pos": [165, 169]}], "task": "NER"}
{"text": "On the other hand , V3 \" values were not significantly correlated with the degree of tremor , seborrhea , and duration of the illness .", "entity": [], "task": "NER"}
{"text": "The isomerization of the pre - existing closed complex to an open promoter form , as judged by the local denaturation of promoter DNA which rendered sequences from + 5 to - 10 reactive towards KMnO4 , was shown to be fully dependent on NifA .", "entity": [{"entity": "NifA", "entity_type": "GENE", "pos": [236, 240]}], "task": "NER"}
{"text": "Mouse macrophage beta subunit ( CD11b ) cDNA for the CR3 complement receptor / Mac - 1 antigen .", "entity": [{"entity": "Mouse macrophage beta subunit ( CD11b ) cDNA", "entity_type": "GENE", "pos": [0, 44]}, {"entity": "CR3 complement receptor", "entity_type": "GENE", "pos": [53, 76]}, {"entity": "Mac - 1 antigen", "entity_type": "GENE", "pos": [79, 94]}], "task": "NER"}
{"text": "The predicted product exhibits 91 % amino acid identity to the murine voltage - gated potassium channel protein Kv1 . 7 ( Kcna7 ) , which plays an important role in the repolarization of cell membranes .", "entity": [{"entity": "murine voltage - gated potassium channel protein Kv1 . 7", "entity_type": "GENE", "pos": [63, 119]}, {"entity": "Kcna7", "entity_type": "GENE", "pos": [122, 127]}], "task": "NER"}
{"text": "Elective replacement of the aortic root in Marfan ' s syndrome .", "entity": [], "task": "NER"}
{"text": "Principles of thyroid hormone treatment", "entity": [], "task": "NER"}
{"text": "Their main representatives are the American diagnostic and statistical manual of mental disorders , DSM - III , its revised version DSM - III - R and the new international classification of mental disorders iCD - 10 .", "entity": [], "task": "NER"}
{"text": "Each received 20 mL of one of three test solutions : levobupivacaine control , levobupivacaine and fentanyl 2 microg / mL , or levobupivacaine and fentanyl 3 microg / mL .", "entity": [], "task": "NER"}
{"text": "Time for action on hepatitis B immunisation .", "entity": [], "task": "NER"}
{"text": "Kramer Hamburg 1988 , ISBN : 3 926952 07 5 ) , the syndromatic day - to - day shifting of the psychopathological features with manic , depressive and several mixed states has a well - defined time structure , as in 25 patients studied and reported on in this paper .", "entity": [], "task": "NER"}
{"text": "Internal controls over the volume of milk suckled do not appear until infant rats are about 2 weeks of age at which time gastric distension , milk , systemic dehydration , and intestinal hormone cholecystokinin suppress milk intake derived through suckling .", "entity": [{"entity": "intestinal hormone cholecystokinin", "entity_type": "GENE", "pos": [176, 210]}], "task": "NER"}
{"text": "In the HIV LTR , this region has been demonstrated to have both positive and negative regulatory effects on HIV gene expression .", "entity": [{"entity": "HIV LTR", "entity_type": "GENE", "pos": [7, 14]}], "task": "NER"}
{"text": "Analysis of rat brain , heart , lung , liver , kidney and skeletal muscle revealed psi PKC zeta mRNA only in brain .", "entity": [{"entity": "psi PKC zeta mRNA", "entity_type": "GENE", "pos": [83, 100]}], "task": "NER"}
{"text": "To identify and determine the function of Ino2p in yeast cells , we raised antibodies to a beta - galactosidase / Ino2 fusion protein .", "entity": [{"entity": "Ino2p", "entity_type": "GENE", "pos": [42, 47]}, {"entity": "beta - galactosidase", "entity_type": "GENE", "pos": [91, 111]}, {"entity": "Ino2", "entity_type": "GENE", "pos": [114, 118]}], "task": "NER"}
{"text": "In addition , WR - 3689 , WR - 109342 , and WR - 168643 were used with per os administration to determine hematopoietic lethality .", "entity": [], "task": "NER"}
{"text": "Isolation and characterization of human orthologs of yeast CCR4 - NOT complex subunits .", "entity": [{"entity": "CCR4", "entity_type": "GENE", "pos": [59, 63]}, {"entity": "NOT", "entity_type": "GENE", "pos": [66, 69]}], "task": "NER"}
{"text": "Serum AFP is a useful tumor marker for monitoring the results of therapy .", "entity": [{"entity": "AFP", "entity_type": "GENE", "pos": [6, 9]}], "task": "NER"}
{"text": "The paper calls for standardized question formats and a centralized body to monitor changes in these parameters of sexual behaviour .", "entity": [], "task": "NER"}
{"text": "A heterologous promoter construct containing three repeats of a consensus Sp1 site , cloned upstream of a single copy of the ZII ( CREB / AP1 ) element from the BZLF1 promoter linked to the beta - globin TATA box , exhibited phorbol ester inducibility .", "entity": [{"entity": "Sp1 site", "entity_type": "GENE", "pos": [74, 82]}, {"entity": "ZII", "entity_type": "GENE", "pos": [125, 128]}, {"entity": "CREB", "entity_type": "GENE", "pos": [131, 135]}, {"entity": "AP1", "entity_type": "GENE", "pos": [138, 141]}, {"entity": "BZLF1 promoter", "entity_type": "GENE", "pos": [161, 175]}, {"entity": "beta - globin", "entity_type": "GENE", "pos": [190, 203]}], "task": "NER"}
{"text": "A long - term follow - up study of a children ' s psychiatric day treatment center .", "entity": [], "task": "NER"}
{"text": "Risk factors for atherosclerosis related to nutrition are hypercholesterolemia , hyperglycemia - diabetes , and for hypertension , obesity , high salt intake , and excessive use of alcohol .", "entity": [], "task": "NER"}
{"text": "We demonstrate that the recently proposed synthetic imaging technique [ J .", "entity": [], "task": "NER"}
{"text": "We compared the quantities collected with both pollen traps during February , March and April 1988 and 1989 .", "entity": [], "task": "NER"}
{"text": "Of the CSF tested , 24 stimulated oxygen consumption above our cut off , and 8 did not ( 0 . 84 + / - 0 . 34 , n = 24 compared with the rate of 0 . 27 + / - 0 . 1 mumol / min / g dry wt , respectively ; SD n = 8 ) at 180 minutes .", "entity": [], "task": "NER"}
{"text": "These psoralens are being used in research projects sponsored by the National Toxicology Program .", "entity": [], "task": "NER"}
{"text": "Four of 15 patients with R2 had rheumatoid arthritis and in two of these four cases the antibody was of the IgA class .", "entity": [{"entity": "R2", "entity_type": "GENE", "pos": [25, 27]}, {"entity": "IgA", "entity_type": "GENE", "pos": [108, 111]}], "task": "NER"}
{"text": "Seventy - nine percent of the children screened and 91 . 0 % of the children with PbB at least 10 micrograms / dL were Hispanic .", "entity": [], "task": "NER"}
{"text": "We report here on an eight - year - old boy who first developed acute intravascular hemolysis following therapy with amphotericin B ( AmB ) and subsequently a delayed hemolytic transfusion reaction due to alloantibodies .", "entity": [], "task": "NER"}
{"text": "However , no significant difference in either the Valsalva ratio or delta SBP was found between diabetic patients and controls .", "entity": [], "task": "NER"}
{"text": "The PDSS identified 17 ( 94 % ) of the women diagnosed with major postpartum depression , the EPDS identified 14 of these women ( 78 % ) , and the BDI - II identified 10 of the 18 women ( 56 % ) .", "entity": [], "task": "NER"}
{"text": "One ORF extends from nucleotides 415 to 1620 , encodes 402 amino acids , and is preceded by a ribosome - binding site .", "entity": [], "task": "NER"}
{"text": "Blood coagulation Factor X and its activated form Factor Xa play an essential role in the midphase of the clotting cascade .", "entity": [{"entity": "Blood coagulation Factor X", "entity_type": "GENE", "pos": [0, 26]}, {"entity": "Factor Xa", "entity_type": "GENE", "pos": [50, 59]}], "task": "NER"}
{"text": "The Ras GTPase - activating - protein - related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases .", "entity": [{"entity": "Ras GTPase - activating - protein - related human protein", "entity_type": "GENE", "pos": [4, 61]}, {"entity": "IQGAP2", "entity_type": "GENE", "pos": [62, 68]}, {"entity": "actin binding domain", "entity_type": "GENE", "pos": [89, 109]}, {"entity": "calmodulin", "entity_type": "GENE", "pos": [129, 139]}, {"entity": "Rho family GTPases", "entity_type": "GENE", "pos": [144, 162]}], "task": "NER"}
{"text": "On a national level , undiscounted costs are expected to increase up to approximately DF1 42 million annually during the first 40 years after introduction of the preventative strategy .", "entity": [], "task": "NER"}
{"text": "Reduction of p53 protein was detected after 1 day of OM treatment and reached maximal suppression of 10 - 20 % of control after 3 days in H3922 and 40 % of control after 4 days in MCF - 7 cells .", "entity": [{"entity": "p53 protein", "entity_type": "GENE", "pos": [13, 24]}, {"entity": "OM", "entity_type": "GENE", "pos": [53, 55]}], "task": "NER"}
{"text": "This seems to take place in the same nuclear compartment as normal cis splicing and proceeds through Y - branched intermediates analogous to the lariats formed in cis splicing .", "entity": [], "task": "NER"}
{"text": "Production of a chicken meat infusion broth suitable for the mass production of a Haemophilus gallinarum bacterin .", "entity": [], "task": "NER"}
{"text": "The maternal par genes and the segregation of cell fate specification activities in early Caenorhabditis elegans embryos .", "entity": [{"entity": "maternal par genes", "entity_type": "GENE", "pos": [4, 22]}], "task": "NER"}
{"text": "These results suggest that E6010 may be of clinical value in the treatment of coronary occlusion .", "entity": [{"entity": "E6010", "entity_type": "GENE", "pos": [27, 32]}], "task": "NER"}
{"text": "Real - time two - dimensional echocardiographic studies of the mitral valve in short - axis view were obtained from 10 normal subjects .", "entity": [], "task": "NER"}
{"text": "We determined their N - terminal amino acid sequence and found that these polypeptides were CotT , YeeK , YxeE , CotF , YrbA ( 31 and 45 kDa ) , and SpoIVA , respectively .", "entity": [{"entity": "CotT", "entity_type": "GENE", "pos": [92, 96]}, {"entity": "YeeK", "entity_type": "GENE", "pos": [99, 103]}, {"entity": "YxeE", "entity_type": "GENE", "pos": [106, 110]}, {"entity": "CotF", "entity_type": "GENE", "pos": [113, 117]}, {"entity": "YrbA", "entity_type": "GENE", "pos": [120, 124]}, {"entity": "SpoIVA", "entity_type": "GENE", "pos": [149, 155]}], "task": "NER"}
{"text": "The determination of diacetyl , 2 , 3 - pentanedione and acetoin was performed in two steps .", "entity": [], "task": "NER"}
{"text": "The same pattern of firing was seen with saccades in light and in complete darkness .", "entity": [], "task": "NER"}
{"text": "The critical obstacle in modeling psychiatric disorders has been limited information about their origin and underlying neural mechanisms .", "entity": [], "task": "NER"}
{"text": "These results suggest that both the distinct DNA binding properties of PMLRAR homodimers and the sequestration of RXR by PMLRARs may contribute to the molecular mechanisms which underlie the pathogenesis of APL .", "entity": [{"entity": "PMLRAR homodimers", "entity_type": "GENE", "pos": [71, 88]}, {"entity": "RXR", "entity_type": "GENE", "pos": [114, 117]}, {"entity": "PMLRARs", "entity_type": "GENE", "pos": [121, 128]}], "task": "NER"}
{"text": "CONCLUSIONS : Patients ' attainment of TGB monotherapy was associated with their achievement of positive changes of varying degree on psychological tests .", "entity": [], "task": "NER"}
{"text": "In alfalfa , the insecticides caused significant mortality to most of the insects evaluated .", "entity": [], "task": "NER"}
{"text": "Sixtieth anniversary of Angiotensin .", "entity": [{"entity": "Angiotensin", "entity_type": "GENE", "pos": [24, 35]}], "task": "NER"}
{"text": "In addition , we found that the transactivation mediated by the p68c - ets - 1 pr p55erg through the Polyomavirus enhancer sequence is specifically inhibited by the p46kDaPax - QNR in transient transfection assay .", "entity": [{"entity": "p68c - ets - 1 pr", "entity_type": "GENE", "pos": [64, 81]}, {"entity": "p55erg", "entity_type": "GENE", "pos": [82, 88]}, {"entity": "Polyomavirus enhancer sequence", "entity_type": "GENE", "pos": [101, 131]}, {"entity": "p46kDaPax - QNR", "entity_type": "GENE", "pos": [165, 180]}], "task": "NER"}
{"text": "SCAN boxes are found in eight other genes in the GenBank database , five of which are also in the Kruppel family of zinc finger proteins lacking KRAB A and B domains and thereby define a new subclass of zinc finger proteins .", "entity": [{"entity": "SCAN", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "Kruppel family", "entity_type": "GENE", "pos": [98, 112]}, {"entity": "zinc finger proteins", "entity_type": "GENE", "pos": [116, 136]}, {"entity": "KRAB A and B", "entity_type": "GENE", "pos": [145, 157]}, {"entity": "zinc finger proteins", "entity_type": "GENE", "pos": [203, 223]}], "task": "NER"}
{"text": "The in - plane orientational anisotropy of the 8CB films grown on unidirectionally photopolymerized PVCN substrates is considerably lower than the intrinsic surface orientational anisotropy of these substrates , which can explain the generally found weak surface anchoring of liquid crystals on PVCN alignment layers .", "entity": [], "task": "NER"}
{"text": "The introduction of FWD1 into cells significantly promotes ubiquitination and degradation of IkappaBalpha in concert with IkappaB kinases , resulting in nuclear translocation of NF - kappaB .", "entity": [{"entity": "FWD1", "entity_type": "GENE", "pos": [20, 24]}, {"entity": "IkappaBalpha", "entity_type": "GENE", "pos": [93, 105]}, {"entity": "IkappaB kinases", "entity_type": "GENE", "pos": [122, 137]}, {"entity": "NF - kappaB", "entity_type": "GENE", "pos": [178, 189]}], "task": "NER"}
{"text": "Since blood serotonin is primarily produced peripherally , these results suggest that some aspect of peripheral serotonin metabolism is abnormal in major depression .", "entity": [], "task": "NER"}
{"text": "She had been diagnosed with severe aplastic anemia 1 year previously and , while hospitalized , had received methyl prednisolone pulse therapy , which was not successful .", "entity": [], "task": "NER"}
{"text": "We next developed a rapid purification method for bacterial recombinant MyoD - bHLH domain by affinity chromatography using a calmodulin - Sepharose column and investigated the phosphorylation of that peptide by PKC and its interactions with calmodulin and S100a .", "entity": [{"entity": "bacterial recombinant MyoD - bHLH domain", "entity_type": "GENE", "pos": [50, 90]}, {"entity": "calmodulin", "entity_type": "GENE", "pos": [126, 136]}, {"entity": "PKC", "entity_type": "GENE", "pos": [212, 215]}, {"entity": "calmodulin", "entity_type": "GENE", "pos": [242, 252]}, {"entity": "S100a", "entity_type": "GENE", "pos": [257, 262]}], "task": "NER"}
{"text": "The 22 - d orbital flight of rats onboard the Cosmos - 605 biosatellite was followed by inhibition of erythroblastosis , alteration in the morphology of megakaryocytes , and stimulation of myelopoiesis .", "entity": [], "task": "NER"}
{"text": "Partial albinism and immunodeficiency : ultrastructural study of haemophagocytosis and bone marrow erythroblasts in one case .", "entity": [], "task": "NER"}
{"text": "Optical rotation of the second harmonic radiation from retinal in bacteriorhodopsin monomers in Langmuir - Blodgett film : evidence for nonplanar retinal structure .", "entity": [{"entity": "bacteriorhodopsin monomers", "entity_type": "GENE", "pos": [66, 92]}], "task": "NER"}
{"text": "RESULTS : Twenty - two patients ( 30 % ) showed ST - segment depression during AEM and 34 ( 49 % ) on ExT .", "entity": [], "task": "NER"}
{"text": "Enhanced quantum correlations in bound higher - order solitons Quantum effects in N - bound solitons can be drastically enhanced compared to the fundamental soliton .", "entity": [], "task": "NER"}
{"text": "Acute intoxication with cypermethrin ( NRDC 149 ) .", "entity": [], "task": "NER"}
{"text": "Anesthesia in the radical surgery of arteriosclerotic coronary disease", "entity": [], "task": "NER"}
{"text": "Whereas the sequence of alpha - actinin ( Noegel , A . , W .", "entity": [{"entity": "alpha - actinin", "entity_type": "GENE", "pos": [24, 39]}], "task": "NER"}
{"text": "Overall , it appears that prenatal exposure to androgen - based synthetic progestin exerted a masculinizing and / or defeminizing influence on human behavioral development , whereas prenatal exposure to natural progesterone and progesterone - based synthetic progestin had a feminizing and / or demasculinizing influence , particularly among female subjects .", "entity": [], "task": "NER"}
{"text": "CONCLUSION : In an acute canine model of progressive LCX coronary stenosis , CFR was impaired in both ischemic and remote nonischemic regions in association with mild to moderate ischemic - induced regional myocardial dysfunction .", "entity": [], "task": "NER"}
{"text": "Parathyroid hormone responses of cyclic AMP - , serum - and phorbol ester - responsive reporter genes in osteoblast - like UMR - 106 cells .", "entity": [{"entity": "Parathyroid hormone", "entity_type": "GENE", "pos": [0, 19]}], "task": "NER"}
{"text": "Genome timeline .", "entity": [], "task": "NER"}
{"text": "The \" Ulm Zucker Uhr System \" comprises a microdialysis probe , a biosensor ( Glucosensor Unitec Ulm s . c . ) , a sender transferring telemetrically the glucose concentrations , and a receiving indicator .", "entity": [], "task": "NER"}
{"text": "Previous work has shown that glucose repression of PRB1 transcription is not mediated by HXK2 or by the SNF1 , SNF4 , and SNF6 genes ( C .", "entity": [{"entity": "PRB1", "entity_type": "GENE", "pos": [51, 55]}, {"entity": "HXK2", "entity_type": "GENE", "pos": [89, 93]}, {"entity": "SNF1", "entity_type": "GENE", "pos": [104, 108]}, {"entity": "SNF4", "entity_type": "GENE", "pos": [111, 115]}, {"entity": "SNF6 genes", "entity_type": "GENE", "pos": [122, 132]}], "task": "NER"}
{"text": "The cumulative experience in liver transplantation since the introduction of cyclosporine A has confirmed its efficacy in the treatment of diverse liver diseases in children and adults .", "entity": [], "task": "NER"}
{"text": "Our objective was to find possible predictors for the expression and progression of LJM and to evaluate the relationship between LJM and other long - term complications of insulin - dependent diabetes mellitus .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [172, 179]}], "task": "NER"}
{"text": "To test this hypothesis , we developed a system of transient transfection of rat adipocytes with constructs containing glyceraldehyde - 3 - phosphate dehydrogenase ( GAPDH ) and fatty acid synthetase ( FAS ) promoters fused to gene reporter CAT .", "entity": [{"entity": "glyceraldehyde - 3 - phosphate dehydrogenase", "entity_type": "GENE", "pos": [119, 163]}, {"entity": "GAPDH", "entity_type": "GENE", "pos": [166, 171]}, {"entity": "fatty acid synthetase", "entity_type": "GENE", "pos": [178, 199]}, {"entity": "FAS", "entity_type": "GENE", "pos": [202, 205]}, {"entity": "gene reporter CAT", "entity_type": "GENE", "pos": [227, 244]}], "task": "NER"}
{"text": "Comparison of this gene with the available databases reveals very significant homology to the ETS factor PE - 1 and probable near - identity with the recently cloned factor ERF .", "entity": [{"entity": "ETS factor", "entity_type": "GENE", "pos": [94, 104]}, {"entity": "PE - 1", "entity_type": "GENE", "pos": [105, 111]}, {"entity": "ERF", "entity_type": "GENE", "pos": [173, 176]}], "task": "NER"}
{"text": "Eight of these suppressors for into two complementation groups , designated KCS1 and KCS2 .", "entity": [{"entity": "KCS1", "entity_type": "GENE", "pos": [76, 80]}, {"entity": "KCS2", "entity_type": "GENE", "pos": [85, 89]}], "task": "NER"}
{"text": "Also , the absence of PdNi between the segments reduces the heat production of the seed .", "entity": [], "task": "NER"}
{"text": "Further analysis of the CAP59 locus of Cryptococcus neoformans : structure defined by forced expression and description of a new ribosomal protein - encoding gene .", "entity": [{"entity": "CAP59 locus of Cryptococcus neoformans", "entity_type": "GENE", "pos": [24, 62]}, {"entity": "ribosomal protein - encoding gene", "entity_type": "GENE", "pos": [129, 162]}], "task": "NER"}
{"text": "The results showed a significant group effect only on the active task .", "entity": [], "task": "NER"}
{"text": "Localization of the porcine enzyme in the endoplasmic reticulum is consistent with immuno - electron - microscopic studies using pig hepatocytes .", "entity": [], "task": "NER"}
{"text": "These larger sizes , however , are consistent with predictions from the DNA sequence of the pol gene .", "entity": [{"entity": "pol gene", "entity_type": "GENE", "pos": [92, 100]}], "task": "NER"}
{"text": "More important , ligand - activated insulin and IGF - I receptors phosphorylate SHC proteins in vitro , indicating that SHC proteins could be direct substrates for insulin and IGF - I receptors .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [36, 43]}, {"entity": "IGF - I receptors", "entity_type": "GENE", "pos": [48, 65]}, {"entity": "SHC proteins", "entity_type": "GENE", "pos": [80, 92]}, {"entity": "SHC proteins", "entity_type": "GENE", "pos": [120, 132]}, {"entity": "insulin", "entity_type": "GENE", "pos": [164, 171]}, {"entity": "IGF - I receptors", "entity_type": "GENE", "pos": [176, 193]}], "task": "NER"}
{"text": "International efforts are now being made to standardize haemolytic test conditions and the present study is meant as a contribution to this .", "entity": [], "task": "NER"}
{"text": "The DFA slide prepared from the ThinPrep Test and the conventional DFA sample prepared from the endocervical swab were evaluated independently .", "entity": [], "task": "NER"}
{"text": "We suggest that the responses to types I and II collagen were caused by a cross - reaction with type III collagen peptides .", "entity": [{"entity": "types I and II collagen", "entity_type": "GENE", "pos": [33, 56]}, {"entity": "type III collagen", "entity_type": "GENE", "pos": [96, 113]}], "task": "NER"}
{"text": "The nucleotide sequence of the estrogen receptor gene of Oreochromis aureus ( OaER ) indicates that the hormone - binding E domain is composed of 4 exons interspersed by short introns of only 0 . 18 - 1 . 3 kb each .", "entity": [{"entity": "estrogen receptor gene of Oreochromis aureus", "entity_type": "GENE", "pos": [31, 75]}, {"entity": "OaER", "entity_type": "GENE", "pos": [78, 82]}], "task": "NER"}
{"text": "To test for progesterone receptor - mediated activation of transcription in yeast , reporter plasmids were constructed to transform yeast cells expressing PRB or C1C2 receptors .", "entity": [{"entity": "progesterone receptor", "entity_type": "GENE", "pos": [12, 33]}, {"entity": "PRB", "entity_type": "GENE", "pos": [155, 158]}, {"entity": "C1C2 receptors", "entity_type": "GENE", "pos": [162, 176]}], "task": "NER"}
{"text": "Beyond the first year post - renal transplantation there was no difference in C ( IO ) between LRD and CAD allografts .", "entity": [], "task": "NER"}
{"text": "TAF - 1 activates transcription constitutively and was mapped to the first 32 amino acids of the A - region .", "entity": [{"entity": "TAF - 1", "entity_type": "GENE", "pos": [0, 7]}], "task": "NER"}
{"text": "The ventricular demand pacemaker ( VVI ) was implanted three years ago and because of further impairment of cardiac performance an av - sequential pacemaker ( DDD ) was used to restore atrio - ventricular synchronisation .", "entity": [], "task": "NER"}
{"text": "In the present study we found that CD34 downregulation during hematopoiesis occured at the level of transcriptional initiation .", "entity": [{"entity": "CD34", "entity_type": "GENE", "pos": [35, 39]}], "task": "NER"}
{"text": "Following replicate control measurements , test ramps were repeated in the presence of sodium nitroprusside ( 1 microM ) and phentolamine ( 1 microM ) to eliminate potential smooth muscle and alpha 1 - adrenoceptor effects , respectively .", "entity": [{"entity": "alpha 1 - adrenoceptor", "entity_type": "GENE", "pos": [192, 214]}], "task": "NER"}
{"text": "Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and diacetoxyscirpenol or ochratoxin A in turkey poults .", "entity": [{"entity": "fumonisin B1", "entity_type": "GENE", "pos": [35, 47]}], "task": "NER"}
{"text": "This C - terminal domain contains several YxxI / L motifs reminiscent of LMP2A and a putative TRAF binding site as in LMP1 .", "entity": [{"entity": "LMP2A", "entity_type": "GENE", "pos": [73, 78]}, {"entity": "TRAF binding site", "entity_type": "GENE", "pos": [94, 111]}, {"entity": "LMP1", "entity_type": "GENE", "pos": [118, 122]}], "task": "NER"}
{"text": "Possibilities and limints of immunofluorescence in the laboratory diagnosis of rabies", "entity": [], "task": "NER"}
{"text": "The 4 - nt sequence of the rotavirus 3 ' TE represents by far the shortest of any of the sequence enhancers known to stimulate translation .", "entity": [], "task": "NER"}
{"text": "Muscle and liver biopsies demonstrated the same anomalies , again without branching enzyme deficiency in the liver .", "entity": [{"entity": "branching enzyme", "entity_type": "GENE", "pos": [74, 90]}], "task": "NER"}
{"text": "The 1031 - bp wild - type HIT1 DNA which contained an open reading frame encoding a protein of 164 amino acids and the AGG arginine tRNA gene complemented all hit1 - 1 mutant phenotypes , indicating that the mutant phenotypes were caused by the deletion of these genes .", "entity": [{"entity": "1031 - bp wild - type HIT1 DNA", "entity_type": "GENE", "pos": [4, 34]}, {"entity": "AGG arginine tRNA gene", "entity_type": "GENE", "pos": [119, 141]}, {"entity": "hit1 - 1 mutant phenotypes", "entity_type": "GENE", "pos": [159, 185]}], "task": "NER"}
{"text": "The chicken genome contains two functional nonallelic beta1 , 4 - galactosyltransferase genes .", "entity": [{"entity": "beta1 , 4 - galactosyltransferase genes", "entity_type": "GENE", "pos": [54, 93]}], "task": "NER"}
{"text": "Human CR2 has a restricted cellular distribution , being expressed on B lymphocytes , dendritic cells of the spleen , pharyngeal epithelial cells , and at low levels on some T lymphocytes .", "entity": [{"entity": "Human CR2", "entity_type": "GENE", "pos": [0, 9]}], "task": "NER"}
{"text": "Heterotrimeric guanine nucleotide - binding proteins ( G - proteins ) function as signal transducers for a variety of hormone - coupled enzyme and ion transport systems in eukaryotic cells .", "entity": [{"entity": "guanine nucleotide - binding proteins", "entity_type": "GENE", "pos": [15, 52]}, {"entity": "G - proteins", "entity_type": "GENE", "pos": [55, 67]}], "task": "NER"}
{"text": "The enzyme ACC oxidase catalyses the last step of ethylene biosynthesis in plants , converting 1 - aminocyclopropane - 1 - carboxylic acid ( ACC ) to ethylene .", "entity": [{"entity": "enzyme ACC oxidase", "entity_type": "GENE", "pos": [4, 22]}], "task": "NER"}
{"text": "Virol .", "entity": [], "task": "NER"}
{"text": "Mibefradil ( Ro 40 - 5967 ) is a novel nondihydropyridine calcium antagonist .", "entity": [], "task": "NER"}
{"text": "We have used the chloramphenicol acetyltransferase ( CAT ) reporter gene system to study the effect of T on the long terminal repeats ( LTRs ) of a large family of human endogenous retrovirus - like sequences , RTVL - H .", "entity": [{"entity": "chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [17, 50]}, {"entity": "CAT", "entity_type": "GENE", "pos": [53, 56]}, {"entity": "T", "entity_type": "GENE", "pos": [103, 104]}], "task": "NER"}
{"text": "They contain a large ( 0 . 9 X 10 ( 3 ) to 1 . 88 X 10 ( 3 ) base - pairs ) intron in the middle of the gene and are further interrupted close to the 5 ' end of the gene .", "entity": [], "task": "NER"}
{"text": "The recombinant containing the full - length polyhedrin leader sequence gave levels of N mRNA comparable to those of AcNPV polyhedrin mRNA .", "entity": [{"entity": "polyhedrin", "entity_type": "GENE", "pos": [45, 55]}, {"entity": "N mRNA", "entity_type": "GENE", "pos": [87, 93]}, {"entity": "AcNPV polyhedrin mRNA", "entity_type": "GENE", "pos": [117, 138]}], "task": "NER"}
{"text": "Long - term results and curative mechanisms of vesicoureteral reflux by endoscopic injection of blood .", "entity": [], "task": "NER"}
{"text": "Primer extension experiments using dbcAMP - differentiated U937 RNA indicated a single transcriptional initiation site .", "entity": [], "task": "NER"}
{"text": "Sequences within and flanking hypersensitive sites 3 and 2 of the beta - globin locus control region required for synergistic versus additive interaction with the epsilon - globin gene promoter .", "entity": [{"entity": "beta - globin", "entity_type": "GENE", "pos": [66, 79]}, {"entity": "epsilon - globin gene promoter", "entity_type": "GENE", "pos": [163, 193]}], "task": "NER"}
{"text": "Four of 12 patients ( 33 % ) were initially diagnosed as having a benign disease ( false - negatives ) .", "entity": [], "task": "NER"}
{"text": "The mean was 66 cells / mm2 in the laser group and 63 . 7 cells / mm2 in the control group .", "entity": [], "task": "NER"}
{"text": "Using reporter gene constructs driven by the CD4 promoter , we report that HHV - 6 can efficiently transactivate such genetic elements .", "entity": [{"entity": "CD4 promoter", "entity_type": "GENE", "pos": [45, 57]}], "task": "NER"}
{"text": "Through genomic library screening and PCR - based genomic walking we have now cloned the mouse E - Tmod gene , whose coding region spans approximately 60kb containing nine exons and eight introns .", "entity": [{"entity": "mouse E - Tmod gene", "entity_type": "GENE", "pos": [89, 108]}], "task": "NER"}
{"text": "On a variety of fronts , chronic bacterial infection is being found to be significantly associated with the development of atherosclerosis and the clinical complications of unstable angina , myocardial infarction , and stroke .", "entity": [], "task": "NER"}
{"text": "Cost analysis and the HSA : a framework .", "entity": [], "task": "NER"}
{"text": "Removal of ink4a dramatically reduces the lymphoid and neurological defects seen in bmi - 1 - deficient mice , indicating that ink4a is a critical in vivo target for Bmi - 1 .", "entity": [{"entity": "ink4a", "entity_type": "GENE", "pos": [11, 16]}, {"entity": "bmi - 1", "entity_type": "GENE", "pos": [84, 91]}, {"entity": "ink4a", "entity_type": "GENE", "pos": [127, 132]}, {"entity": "Bmi - 1", "entity_type": "GENE", "pos": [166, 173]}], "task": "NER"}
{"text": "In fifty non selected ductal carcinomas of the breast we found that a marked tumoral inflammatory infiltrate ( P less than 0 . 025 ) , perinodal tumoral infiltrate ( P less than 0 . 01 ) , sinus catarrh ( P less than 0 . 05 ) , follicular hyperplasia ( P less than 0 . 025 ) , mixed pattern in lymph nodes ( P less than 0 . 01 ) and with 54 years of age or younger ( P less than 0 . 01 ) correlated significantly with lymph node metastases and / or high histologic grade .", "entity": [], "task": "NER"}
{"text": "The herpesvirus entry mediator C ( HveC ) , previously known as poliovirus receptor - related protein 1 ( PRR1 ) , and the herpesvirus Ig - like receptor ( HIgR ) are the bona fide receptors employed by herpes simplex virus - 1 and - 2 ( HSV - 1 and - 2 ) for entry into the human cell lines most frequently used in HSV studies .", "entity": [{"entity": "herpesvirus entry mediator C", "entity_type": "GENE", "pos": [4, 32]}, {"entity": "HveC", "entity_type": "GENE", "pos": [35, 39]}, {"entity": "poliovirus receptor - related protein 1", "entity_type": "GENE", "pos": [64, 103]}, {"entity": "PRR1", "entity_type": "GENE", "pos": [106, 110]}, {"entity": "herpesvirus Ig - like receptor", "entity_type": "GENE", "pos": [123, 153]}, {"entity": "HIgR", "entity_type": "GENE", "pos": [156, 160]}], "task": "NER"}
{"text": "Spinal injuries in a multiple trauma patient .", "entity": [], "task": "NER"}
{"text": "Creatinine and creatine phosphokinase ( CPK ) .", "entity": [{"entity": "creatine phosphokinase", "entity_type": "GENE", "pos": [15, 37]}, {"entity": "CPK", "entity_type": "GENE", "pos": [40, 43]}], "task": "NER"}
{"text": "The glyoxysomal and plastid molecular chaperones ( 70 - kDa heat shock protein ) of watermelon cotyledons are encoded by a single gene .", "entity": [{"entity": "70 - kDa heat shock protein", "entity_type": "GENE", "pos": [51, 78]}], "task": "NER"}
{"text": "Thus , cross - resistance between fluoroquinolones was shown for both enterococci and MRSA .", "entity": [], "task": "NER"}
{"text": "Furthermore we elucidate the subtle highly anisotropic interchain correlations and reveal the detailed atomic structure of the low - temperature ( 8x2 ) phase .", "entity": [], "task": "NER"}
{"text": "025 ) .", "entity": [], "task": "NER"}
{"text": "With stimulation beyond the theta - range three phenomena occurred : shift of the burst frequencies to higher or lower harmonics of stimulation frequencies ; complex interactions of basic background frequency with rhythm of stimulation ( \" beating \" ) ; return to background theta - burst frequency in spite of continuing stimulation ( \" escape \" ) .", "entity": [], "task": "NER"}
{"text": "Incorporation of this information in the data brought about a revised five - year survival estimate of 55 percent .", "entity": [], "task": "NER"}
{"text": "Using a dominant negative form of Sp3 and transcriptional activation assays in Schneider SL - 2 insect cells , it was confirmed that ERalpha - Sp3 interactions define a pathway for E2 - mediated inhibition of gene expression , and this represents a new mechanism for decreased gene expression by E2 .", "entity": [{"entity": "Sp3", "entity_type": "GENE", "pos": [34, 37]}, {"entity": "ERalpha", "entity_type": "GENE", "pos": [133, 140]}, {"entity": "Sp3", "entity_type": "GENE", "pos": [143, 146]}, {"entity": "E2", "entity_type": "GENE", "pos": [181, 183]}, {"entity": "E2", "entity_type": "GENE", "pos": [296, 298]}], "task": "NER"}
{"text": "While these could be unusual cases of chronic non - A , non - B hepatitis , this can be only speculation until a serologic test for non - A , non - B hepatitis becomes available .", "entity": [], "task": "NER"}
{"text": "Our previous studies demonstrated that the promyelocytic leukemia gene , PML which involved in the 15 ; 17 translocation in acute promyelocytic leukemia ( APL ) is a growth and transformation suppressor .", "entity": [{"entity": "PML", "entity_type": "GENE", "pos": [73, 76]}], "task": "NER"}
{"text": "These characteristics add to the suitability of NM441 as an effective prodrug of NM394 .", "entity": [], "task": "NER"}
{"text": "Sequence analysis of cDNA clones encoding human gamma revealed an open reading frame predicting a protein of 299 amino acids ( approximately 32 kDa ) , half the size of the bovine gamma subunit .", "entity": [], "task": "NER"}
{"text": "DISCUSSION : The higher absolute knee extension strength measures of leg and the similar extension strength of the trunk in the obese sample compared to the lean might be explained by the training effect of weight bearing and support of a larger body mass .", "entity": [], "task": "NER"}
{"text": "Measuring the dim light melatonin onset ( DLMO ) is a useful and practical way to assess circadian phase position in humans .", "entity": [], "task": "NER"}
{"text": "Although the energy - based DFT was not affected by isoproterenol ( from 6 . 1 + / - 1 . 5 to 6 . 0 + / - 1 . 7 J ) , it was decreased to 3 . 7 + / - 1 . 6 J in the third stage by infusion of E4031 and isoproterenol ( p < 0 . 01 vs . baseline and vs . isoproterenol ) .", "entity": [], "task": "NER"}
{"text": "This communication presents two patients with clinically massive PE of recent onset ( confirmed by lung perfusion scans ) who were successfully treated with a single i . v . dose of 30 mg of anisoylated lys - plasminogen streptokinase activator complex ( APSAC , comparable to 1 , 500 , 000 U of streptokinase ) followed by systemic heparinization for 7 days .", "entity": [{"entity": "anisoylated lys - plasminogen streptokinase activator complex", "entity_type": "GENE", "pos": [191, 252]}, {"entity": "APSAC", "entity_type": "GENE", "pos": [255, 260]}, {"entity": "streptokinase", "entity_type": "GENE", "pos": [296, 309]}], "task": "NER"}
{"text": "Capillary tortuosity was a function of sarcomere length in all animals and this relationship was not changed by hypoxia .", "entity": [], "task": "NER"}
{"text": "A survey of children with HBsAg markers related to their parents HBV markers .", "entity": [{"entity": "HBsAg markers", "entity_type": "GENE", "pos": [26, 39]}], "task": "NER"}
{"text": "In cases of intracapsular prostatic cancer the level of prostatic acid phosphatase ( PAP ) measured by radioimmunoassay was 1 . 4 + / - 0 . 8 micrograms / l .", "entity": [{"entity": "prostatic acid phosphatase", "entity_type": "GENE", "pos": [56, 82]}, {"entity": "PAP", "entity_type": "GENE", "pos": [85, 88]}], "task": "NER"}
{"text": "Rv was 7 . 7 + / - 1 . 4 mmHg . ml - 1 . min . 100 g - 1 and Cv was 0 . 59 + / - 0 . 25 ml / mmHg , tau v calculated from the product of Rv and Cv was 4 . 20 + / - 1 . 58 s and from the ratio of delta V to delta Q was 4 . 95 + / - 1 . 53 s ( P = NS ) at a mean Pel of 17 . 6 + / - 3 . 7 mmHg . delta V was also produced by changing Pv ; the average tau v ( 1 . 95 + / - 0 . 37 s ) , was shorter than that with changes in flow .", "entity": [], "task": "NER"}
{"text": "Peripheral neuropathy in the cherry - red spot - myoclonus syndrome ( sialidosis type I ) .", "entity": [], "task": "NER"}
{"text": "The meaning of hope in health and illness .", "entity": [], "task": "NER"}
{"text": "For O3 , the correlation between personal exposures and ambient levels was weakest in the winter for residential microenvironments ( rs = 0 . 05 , p > 0 . 05 ) , and was strongest in the summer for outdoor near - roadway microenvironments ( rs = 0 . 91 , p < 0 . 05 ) .", "entity": [], "task": "NER"}
{"text": "The myb proto oncogene product ( c - Myb ) is a transcriptional regulator and its expression and function are tightly linked to the cellular entry into S phase and DNA synthesis .", "entity": [{"entity": "myb proto oncogene product", "entity_type": "GENE", "pos": [4, 30]}, {"entity": "c - Myb", "entity_type": "GENE", "pos": [33, 40]}], "task": "NER"}
{"text": "However , and in contrast to other MMP genes , no significative synergistic effect on CAT activity between the AP - 1 and PEA - 3 elements found in the collagenase - 3 gene promoter was found .", "entity": [{"entity": "MMP genes", "entity_type": "GENE", "pos": [35, 44]}, {"entity": "CAT", "entity_type": "GENE", "pos": [86, 89]}, {"entity": "AP - 1", "entity_type": "GENE", "pos": [111, 117]}, {"entity": "PEA - 3 elements", "entity_type": "GENE", "pos": [122, 138]}, {"entity": "collagenase - 3 gene promoter", "entity_type": "GENE", "pos": [152, 181]}], "task": "NER"}
{"text": "CONCLUSIONS : The number of Spanish articles published in Anesthesiology , BJA , and Anesth Analg is low , although the comparison of our productivity with that of other EU countries in function of GNPpc places us in an intermediate position .", "entity": [], "task": "NER"}
{"text": "This fragment contains two complete endo - beta - 1 , 4 - glucanase - encoding genes , designated celCCC and celCCG .", "entity": [{"entity": "endo - beta - 1 , 4 - glucanase - encoding genes", "entity_type": "GENE", "pos": [36, 84]}, {"entity": "celCCC", "entity_type": "GENE", "pos": [98, 104]}, {"entity": "celCCG", "entity_type": "GENE", "pos": [109, 115]}], "task": "NER"}
{"text": "The \" Gregg phenomenon \" implies that myocardial function and oxygen consumption ( MVO2 ) increase when coronary perfusion is enhanced within or above the autoregulatory range .", "entity": [], "task": "NER"}
{"text": "Pollinosis in the U . A . R .", "entity": [], "task": "NER"}
{"text": "The use of sigma 54 promoters , known to require cognate binding proteins , could allow the fine - tuning that provides the temporal ordering of flagellar gene transcription .", "entity": [{"entity": "sigma 54 promoters", "entity_type": "GENE", "pos": [11, 29]}], "task": "NER"}
{"text": "Over a period of five training sessions ( 2 . 5 days ) , the animals learned not to breathe , and the number of stimuli received in the fifth session was significantly lower than in the first session .", "entity": [], "task": "NER"}
{"text": "The genes on each chromosome involved in this translocation have been identified as the transcription factor - encoding genes PAX3 and FKHR .", "entity": [{"entity": "PAX3", "entity_type": "GENE", "pos": [126, 130]}, {"entity": "FKHR", "entity_type": "GENE", "pos": [135, 139]}], "task": "NER"}
{"text": "We found that the PRP20 gene is identical to the yeast SRM1 gene ( Clark and Sprague 1989 ) .", "entity": [{"entity": "PRP20 gene", "entity_type": "GENE", "pos": [18, 28]}, {"entity": "yeast SRM1 gene", "entity_type": "GENE", "pos": [49, 64]}], "task": "NER"}
{"text": "Transcriptional activation of the proopiomelanocortin gene by cyclic AMP - responsive element binding protein .", "entity": [{"entity": "proopiomelanocortin gene", "entity_type": "GENE", "pos": [34, 58]}, {"entity": "cyclic AMP - responsive element binding protein", "entity_type": "GENE", "pos": [62, 109]}], "task": "NER"}
{"text": "Recombinant Human Erythropoietin and Platinum - Based Chemotherapy In Advanced Ovarian Cancer", "entity": [{"entity": "Recombinant Human Erythropoietin", "entity_type": "GENE", "pos": [0, 32]}], "task": "NER"}
{"text": "After discharge , he was finally given a diagnosis of PCH because a Donath - Landsteiner test was positive .", "entity": [], "task": "NER"}
{"text": "Human forearm was used as a dummy ear and the electrode HN - 5 was fixed thereon , and a sound stimulus of 90dBnHL was delivered by the earphone ( NC - 3 ) .", "entity": [], "task": "NER"}
{"text": "Neonatal hyperthyroidism", "entity": [], "task": "NER"}
{"text": "We found that the frequency spectrum of physiologic chest sounds is contained entirely within that of jet rotocraft noise .", "entity": [], "task": "NER"}
{"text": "However , their stability was low as already reported for the ARS in S . occidentalis .", "entity": [], "task": "NER"}
{"text": "When gene conversion is initiated by a double - strand break ( DSB ) , any nonhomologous DNA that may be present at the ends must be removed before new DNA synthesis can be initiated .", "entity": [], "task": "NER"}
{"text": "MRI visualization of proteoglycan depletion in articular cartilage via intravenous administration of Gd - DTPA .", "entity": [], "task": "NER"}
{"text": "Furthermore , the GC - rich sequences could confer Sp1 - dependent transactivation to a heterologous prolactin minimal promoter .", "entity": [{"entity": "Sp1", "entity_type": "GENE", "pos": [51, 54]}, {"entity": "prolactin minimal promoter", "entity_type": "GENE", "pos": [101, 127]}], "task": "NER"}
{"text": "Neuronal activity of 58 dopaminergic ( DA ) and 200 non - dopaminergic ( non - DA ) neurons in the ventral tegmental area ( VTA ) of female monkeys was recorded , and correlation to bar press feeding , sensory stimulation and change in motivation was investigated .", "entity": [], "task": "NER"}
{"text": "Serum prolactin rapidly decreased after institution of treatment , with actual normalization ( less than 20 ng / ml ) by the 3rd month .", "entity": [{"entity": "prolactin", "entity_type": "GENE", "pos": [6, 15]}], "task": "NER"}
{"text": "It is required for correct expression of both genes .", "entity": [], "task": "NER"}
{"text": "Cloning the cDNA for a new human zinc finger protein defines a group of closely related Kruppel - like transcription factors .", "entity": [{"entity": "human zinc finger protein", "entity_type": "GENE", "pos": [27, 52]}, {"entity": "Kruppel - like transcription factors", "entity_type": "GENE", "pos": [88, 124]}], "task": "NER"}
{"text": "Recently , we and other laboratories have identified a family of caveolin - related proteins ; caveolin has been re - termed caveolin - 1 .", "entity": [{"entity": "caveolin - related proteins", "entity_type": "GENE", "pos": [65, 92]}, {"entity": "caveolin", "entity_type": "GENE", "pos": [95, 103]}, {"entity": "caveolin - 1", "entity_type": "GENE", "pos": [125, 137]}], "task": "NER"}
{"text": "Six cDNAs represent human homologs of genes known in other species , namely , mouse HSPE71 , Rat RhoGAP protein , S cerevisiae leucyl tRNA synthetase and S cerevisiae chromosome II ORF YBLO44W .", "entity": [{"entity": "mouse HSPE71", "entity_type": "GENE", "pos": [78, 90]}, {"entity": "Rat RhoGAP protein", "entity_type": "GENE", "pos": [93, 111]}, {"entity": "S cerevisiae leucyl tRNA synthetase", "entity_type": "GENE", "pos": [114, 149]}, {"entity": "S cerevisiae chromosome II ORF YBLO44W", "entity_type": "GENE", "pos": [154, 192]}], "task": "NER"}
{"text": "Three high - amylose rice varieties , IR42 , IR36 , and IR62 , with similar chemical composition including amylose content ( 26 . 7 - 27 . 0 % ) , were cooked under the same conditions and tested for in vitro digestibility as well as blood glucose and insulin responses in healthy human volunteers .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [252, 259]}], "task": "NER"}
{"text": "The hepatic isoform of 6 - phosphofructo - 2 - kinase / fructose - 2 , 6 - bisphosphatase ( PF2K / Fru - 2 , 6 - BPase ) is transcriptionally stimulated by glucocorticoids , whereas insulin blocks this stimulatory effect .", "entity": [{"entity": "6 - phosphofructo - 2 - kinase", "entity_type": "GENE", "pos": [23, 53]}, {"entity": "fructose - 2 , 6 - bisphosphatase", "entity_type": "GENE", "pos": [56, 89]}, {"entity": "PF2K", "entity_type": "GENE", "pos": [92, 96]}, {"entity": "Fru - 2 , 6 - BPase", "entity_type": "GENE", "pos": [99, 118]}, {"entity": "insulin", "entity_type": "GENE", "pos": [182, 189]}], "task": "NER"}
{"text": "Such simple injuries may however be accompanied by far reaching consequences .", "entity": [], "task": "NER"}
{"text": "The 132 - bp PHO8p fragment , connected at position - 281 of the 5 ' upstream region of a HIS5 ' - ' lacZ fused gene , could sense Pi signals in vivo , but a 20 - bp synthetic oligonucleotide having the same sequence from - 544 to - 525 of the PHO8p DNA could not .", "entity": [{"entity": "132 - bp PHO8p fragment", "entity_type": "GENE", "pos": [4, 27]}, {"entity": "HIS5 '", "entity_type": "GENE", "pos": [90, 96]}, {"entity": "' lacZ", "entity_type": "GENE", "pos": [99, 105]}, {"entity": "PHO8p DNA", "entity_type": "GENE", "pos": [244, 253]}], "task": "NER"}
{"text": "Antibiotic prophylaxis in a surgical setting", "entity": [], "task": "NER"}
{"text": "In resume response to treatment with usual regimens , doxycycline plus streptomycin of doxycycline rifampicin is good , being however time elapsed until pain ceases of mean length in hospital stay shorter in the group receiving doxycycline plus streptomycin .", "entity": [], "task": "NER"}
{"text": "This indicates changes in postvaccination allergy to BCG .", "entity": [], "task": "NER"}
{"text": "Having demonstrated proper localization of GFP - calmodulin in budding yeast , we examined the localization of a fusion between GFP and calmodulin ( GFP - Camlp ) in fission yeast , where calmodulin had not been localized by any method .", "entity": [{"entity": "GFP", "entity_type": "GENE", "pos": [43, 46]}, {"entity": "calmodulin", "entity_type": "GENE", "pos": [49, 59]}, {"entity": "GFP", "entity_type": "GENE", "pos": [128, 131]}, {"entity": "calmodulin", "entity_type": "GENE", "pos": [136, 146]}, {"entity": "GFP - Camlp", "entity_type": "GENE", "pos": [149, 160]}, {"entity": "calmodulin", "entity_type": "GENE", "pos": [188, 198]}], "task": "NER"}
{"text": "The most common hosts were equines ( 31 % ) , bovines ( 25 % ) and raccoons ( 19 % ) .", "entity": [], "task": "NER"}
{"text": "Between the RNA initiation site and the coding region is a GC - rich hairpin structure followed by 8 T residues that looks like a rho - independent transcription terminator .", "entity": [{"entity": "rho - independent transcription terminator", "entity_type": "GENE", "pos": [130, 172]}], "task": "NER"}
{"text": "In the conscious animals the increase reached statistical significance when the animals were exposed to 12 % oxygen in nitrogen , which produced a fall in arterial PaO2 of 44 . 7 + / - 5 . 0 % .", "entity": [], "task": "NER"}
{"text": "Fourteen eyes ( 38 . 9 % ) developed DLK after an epithelial defect , representing an odds ratio of 13 times .", "entity": [], "task": "NER"}
{"text": "Each subject was injected in the antecubital vein with 7 mg / kg of sodium fluorescein ( 25 % solution ) and measurements were taken 1 hr postinjection at 4 . 5 mm and 7 . 5 mm from the retina .", "entity": [], "task": "NER"}
{"text": "Such tetranucleotides are common in promoter regions , particularly in activating transcription factor / cyclic AMP response element - binding protein ( ATF / CREB ) and E - box motifs , suggesting that PIF may modulate the transcription of many genes .", "entity": [{"entity": "activating transcription factor", "entity_type": "GENE", "pos": [71, 102]}, {"entity": "cyclic AMP response element - binding protein", "entity_type": "GENE", "pos": [105, 150]}, {"entity": "ATF", "entity_type": "GENE", "pos": [153, 156]}, {"entity": "CREB", "entity_type": "GENE", "pos": [159, 163]}, {"entity": "PIF", "entity_type": "GENE", "pos": [203, 206]}], "task": "NER"}
{"text": "The long terminal repeat is 590 bp in length , with the U3 region containing consensus sequences likely to be involved in viral gene expression .", "entity": [], "task": "NER"}
{"text": "A pathogenetic relation with the Eisenmenger ' s syndrome is discussed .", "entity": [], "task": "NER"}
{"text": "Twenty - six calves were subjected to a technique of cryoablation in order to establish an animal model of complete cardiac denervation .", "entity": [], "task": "NER"}
{"text": "The PHO5 gene is activated by the Pho4p transcription factor , which itself is negatively regulated through phosphorylation by the products of PHO80 and PHO85 .", "entity": [{"entity": "PHO5 gene", "entity_type": "GENE", "pos": [4, 13]}, {"entity": "Pho4p transcription factor", "entity_type": "GENE", "pos": [34, 60]}, {"entity": "PHO80", "entity_type": "GENE", "pos": [143, 148]}, {"entity": "PHO85", "entity_type": "GENE", "pos": [153, 158]}], "task": "NER"}
{"text": "CNS preventive treatment without cranial irradiation was effective in all the groups of ALL patients .", "entity": [], "task": "NER"}
{"text": "This deletion disrupts the PU . 1 Ets domain .", "entity": [{"entity": "PU . 1", "entity_type": "GENE", "pos": [27, 33]}, {"entity": "Ets domain", "entity_type": "GENE", "pos": [34, 44]}], "task": "NER"}
{"text": "Basal urinary 17 - hydroxycorticoid ( 17 - OHCS ) values were elevated in 9 / 12 patients and low dose dexamethasone suppression test favoured Cushing ' s syndrome in 8 / 9 patients .", "entity": [], "task": "NER"}
{"text": "In this cross - over controlled study , five male volunteers donated one unit of red cells by MCS and one unit of whole blood by the conventional manual method , 3 months apart .", "entity": [], "task": "NER"}
{"text": "The derepressed expression of fixN was not observed in a purH mutant .", "entity": [{"entity": "fixN", "entity_type": "GENE", "pos": [30, 34]}, {"entity": "purH mutant", "entity_type": "GENE", "pos": [57, 68]}], "task": "NER"}
{"text": "The lipopolysaccharide - binding protein is a secretory class 1 acute - phase protein whose gene is transcriptionally activated by APRF / STAT / 3 and other cytokine - inducible nuclear proteins .", "entity": [{"entity": "secretory class 1 acute - phase protein", "entity_type": "GENE", "pos": [46, 85]}, {"entity": "APRF", "entity_type": "GENE", "pos": [131, 135]}, {"entity": "STAT / 3", "entity_type": "GENE", "pos": [138, 146]}], "task": "NER"}
{"text": "D .", "entity": [], "task": "NER"}
{"text": "Acute renal vein thrombosis in renal allografts : detection with duplex Doppler US .", "entity": [], "task": "NER"}
{"text": "Thus , Shp2 regulates phosphotyrosine - signalling events during the complex ectodermal - mesenchymal interactions that regulate mammalian budding morphogenesis .", "entity": [{"entity": "Shp2", "entity_type": "GENE", "pos": [7, 11]}], "task": "NER"}
{"text": "1 .", "entity": [], "task": "NER"}
{"text": "In conclusion , in coronary artery disease patients , exercise - redistribution 201Thallium cardiac imaging with reinjection at rest can identify severely ischemic but still viable myocardium and may be particularly useful in the prognosis of such patients .", "entity": [], "task": "NER"}
{"text": "To this effect , the present survey puts in evidence that the maximum delay of stream that guarantees the good dimensional stability of these class A alginates is of 45 minutes in the hot and humid climatic tropical country conditions .", "entity": [], "task": "NER"}
{"text": "1995 .", "entity": [], "task": "NER"}
{"text": "The term Kartagener syndrome applies to this syndrome when accompanied by infertility and dextrocardia or situs inversus .", "entity": [], "task": "NER"}
{"text": "Although immunoglobulin and CRP concentration increased , anemia obviously improved with hemoglobin levels increasing from 4 . 8 g / dl to 8 . 5 g / dl without any side effects .", "entity": [{"entity": "immunoglobulin", "entity_type": "GENE", "pos": [9, 23]}, {"entity": "CRP", "entity_type": "GENE", "pos": [28, 31]}, {"entity": "hemoglobin", "entity_type": "GENE", "pos": [89, 99]}], "task": "NER"}
{"text": "These data also demonstrate that insulin and TPA activate MBP / MAP2 kinase activity by de novo phosphorylation of threonine and tyrosine residues via a very similar pathway .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [33, 40]}, {"entity": "MBP", "entity_type": "GENE", "pos": [58, 61]}, {"entity": "MAP2", "entity_type": "GENE", "pos": [64, 68]}], "task": "NER"}
{"text": "100 and 51 p .", "entity": [], "task": "NER"}
{"text": "As regards the short stature , they have proved that the syndrome is related to low levels of somatomedin C ( SmC ) .", "entity": [{"entity": "somatomedin C", "entity_type": "GENE", "pos": [94, 107]}, {"entity": "SmC", "entity_type": "GENE", "pos": [110, 113]}], "task": "NER"}
{"text": "The results obtained with [ F304 ] R2 indicate that structural changes in E . coli R2 in the vicinity of this helix distortion can influence the catalytic activity of the holoenzyme .", "entity": [{"entity": "[ F304 ] R2", "entity_type": "GENE", "pos": [26, 37]}, {"entity": "E . coli R2", "entity_type": "GENE", "pos": [74, 85]}], "task": "NER"}
{"text": "This result is consistent with the previous observation that expression of the hsp70 genes in T . brucei is mainly controlled at the posttranscriptional level .", "entity": [{"entity": "hsp70 genes in T . brucei", "entity_type": "GENE", "pos": [79, 104]}], "task": "NER"}
{"text": "The cloned rRNA operon was transcribed in vitro by using purified RNA polymerase of Escherichia coli .", "entity": [{"entity": "purified RNA polymerase of Escherichia coli", "entity_type": "GENE", "pos": [57, 100]}], "task": "NER"}
{"text": "To test whether Cd exposure would increase Ca release from bone during pregnancy and lactation in relation to the etiological mechanism of Itai - Itai disease , virgin female mice with 45Ca prelabeled skeletons ( 15 microCi / mouse ) were subjected to one round of pregnancy / lactation and were exposed to a Ca - deficient diet containing 0 , 5 , or 25 ppm Cd or 25 ppm Pb for 32 days , from conception until Lactation Day 14 .", "entity": [], "task": "NER"}
{"text": "G - box binding factors ( GBFs ) constitute a family of plant DNA - binding proteins that bind to the G - box motif , a regulatory cis element present in many plant genes with a palindromic DNA motif of CACGTG .", "entity": [{"entity": "G - box binding factors", "entity_type": "GENE", "pos": [0, 23]}, {"entity": "GBFs", "entity_type": "GENE", "pos": [26, 30]}], "task": "NER"}
{"text": "The ferric uptake regulation ( fur ) gene product participates in regulating expression of the manganese - and iron - containing superoxide dismutase genes of Escherichia coli .", "entity": [{"entity": "ferric uptake regulation", "entity_type": "GENE", "pos": [4, 28]}, {"entity": "fur", "entity_type": "GENE", "pos": [31, 34]}, {"entity": "superoxide dismutase genes of Escherichia coli", "entity_type": "GENE", "pos": [129, 175]}], "task": "NER"}
{"text": "This was further suggested by transactivation assays in which mouse fibroblasts were transiently transfected with a human beta - globin reporter gene in the absence and presence of an LKLF cDNA construct .", "entity": [{"entity": "human beta - globin reporter gene", "entity_type": "GENE", "pos": [116, 149]}, {"entity": "LKLF cDNA construct", "entity_type": "GENE", "pos": [184, 203]}], "task": "NER"}
{"text": "On average these maximum potency estimates were within one order of magnitude of the inverse maximum dose tested .", "entity": [], "task": "NER"}
{"text": "Anovulatory cycles with an apparently normal level of blood prolactin .", "entity": [{"entity": "prolactin", "entity_type": "GENE", "pos": [60, 69]}], "task": "NER"}
{"text": "Furthermore , CL100 suppresses the [ val12 ] ras - induced activation of MAP kinase in a cell - free system from Xenopus oocytes .", "entity": [{"entity": "CL100", "entity_type": "GENE", "pos": [14, 19]}, {"entity": "ras", "entity_type": "GENE", "pos": [45, 48]}, {"entity": "MAP kinase", "entity_type": "GENE", "pos": [73, 83]}], "task": "NER"}
{"text": "The maximum levels of reporter proteins attained in transformed cells after prolonged induction represented from 1 % to 7 % of total cellular protein .", "entity": [], "task": "NER"}
{"text": "Cardiovascular drug use and hospitalizations attributable to type 2 diabetes .", "entity": [], "task": "NER"}
{"text": "The PK domain showed pairwise in vitro binding interactions with the pseudokinase , HisRS , and C - term domains ; additionally , the HisRS domain interacted with the C - term region .", "entity": [{"entity": "HisRS", "entity_type": "GENE", "pos": [84, 89]}, {"entity": "HisRS domain", "entity_type": "GENE", "pos": [134, 146]}], "task": "NER"}
{"text": "Renal cell carcinoma induced Coombs negative autoimmune hemolytic anemia and severe thrombocytopenia responsive to nephrectomy .", "entity": [], "task": "NER"}
{"text": "The c - Jun delta - domain inhibits neuroendocrine promoter activity in a DNA sequence - and pituitary - specific manner .", "entity": [{"entity": "c - Jun delta - domain", "entity_type": "GENE", "pos": [4, 26]}], "task": "NER"}
{"text": "Finally , antisense mediated reduction of Elk - 1 in GH4 cells decreased insulin - increased prolactin gene expression and confirmed the requirement for Elk - 1 for insulin - increased prolactin gene expression .", "entity": [{"entity": "Elk - 1", "entity_type": "GENE", "pos": [42, 49]}, {"entity": "insulin", "entity_type": "GENE", "pos": [73, 80]}, {"entity": "prolactin gene", "entity_type": "GENE", "pos": [93, 107]}, {"entity": "Elk - 1", "entity_type": "GENE", "pos": [153, 160]}, {"entity": "insulin", "entity_type": "GENE", "pos": [165, 172]}, {"entity": "prolactin gene", "entity_type": "GENE", "pos": [185, 199]}], "task": "NER"}
{"text": "Smooth pursuit gain and the percentage of total eye movement due to various saccadic subtypes were computed using infrared oculography and computerized pattern recognition software .", "entity": [], "task": "NER"}
{"text": "This is similar to previous reports of muscle creatine phosphokinase release in psychiatric patients .", "entity": [{"entity": "muscle creatine phosphokinase", "entity_type": "GENE", "pos": [39, 68]}], "task": "NER"}
{"text": "The TaqI and HaeIII RFLPs will provide tools for the genetic analysis of CR2 .", "entity": [{"entity": "TaqI", "entity_type": "GENE", "pos": [4, 8]}, {"entity": "HaeIII", "entity_type": "GENE", "pos": [13, 19]}, {"entity": "CR2", "entity_type": "GENE", "pos": [73, 76]}], "task": "NER"}
{"text": "A transient induction of both c - fos and c - jun mRNAs by TPA was observed in both cell populations , together with an associated suppression of BSP mRNA in the fetal rat calvarial cells .", "entity": [{"entity": "c - fos", "entity_type": "GENE", "pos": [30, 37]}, {"entity": "c - jun mRNAs", "entity_type": "GENE", "pos": [42, 55]}, {"entity": "BSP mRNA", "entity_type": "GENE", "pos": [146, 154]}], "task": "NER"}
{"text": "Mitoxantrone plus ara - C is an active combination with great promise for the therapy of previously untreated patients with AML .", "entity": [], "task": "NER"}
{"text": "During an observation period of 12 weeks after halving atenolol from a mean dose of 82 mg to 41 mg , no significant changes in systolic and diastolic blood pressure or in response rate ( defined as a diastolic blood pressure of 95 mm Hg or less ) were observed .", "entity": [], "task": "NER"}
{"text": "Diet imbalances and aflatoxicosis", "entity": [], "task": "NER"}
{"text": "WBC differential ( SEG , BAND , LYMPH , MONO , EOSINO , BASO ) usually showed log - normal distribution .", "entity": [], "task": "NER"}
{"text": "The majority of the respondents ( 83 . 4 % ) considered that coitus should not be stopped during pregnancy .", "entity": [], "task": "NER"}
{"text": "Genetic analyses indicate that most of the dominant mutants are cis - acting and that the recessive mutants define a minimum of three complementation groups , indicating that defects in several different genes can restore higher levels of HIS4C expression .", "entity": [{"entity": "HIS4C", "entity_type": "GENE", "pos": [239, 244]}], "task": "NER"}
{"text": "During normoxic exercise , at a mean O2 uptake ( VO2 ) of 4 . 0 l / min , almitrine increased arterial PO2 ( PaO2 ) ( P < 0 . 05 ) , SaO2 ( P < 0 . 01 ) , and VE ( P < 0 . 05 ) and decreased arterial PCO2 ( P < 0 . 01 ) , without affecting pulmonary hemodynamics or ventilation - perfusion distributions .", "entity": [], "task": "NER"}
{"text": "Recombinant protein encoded by ESX ( for epithelial - restricted with serine box ) exhibits Ets - like DNA binding specificity in electrophoretic mobility shift assays and , in transient transfection assays , transactivates Ets - responsive promoter elements including that found in the HER2 / neu oncogene .", "entity": [{"entity": "ESX", "entity_type": "GENE", "pos": [31, 34]}, {"entity": "epithelial - restricted with serine box", "entity_type": "GENE", "pos": [41, 80]}, {"entity": "Ets - like", "entity_type": "GENE", "pos": [92, 102]}, {"entity": "Ets - responsive promoter elements", "entity_type": "GENE", "pos": [224, 258]}, {"entity": "HER2", "entity_type": "GENE", "pos": [287, 291]}, {"entity": "neu", "entity_type": "GENE", "pos": [294, 297]}], "task": "NER"}
{"text": "Static and dynamic MRI of the normal and pathological female pelvic floor", "entity": [], "task": "NER"}
{"text": "Crystals of the triple mutant A42D / D47P / A63L , which are stable for days in its oxidized form , were grown from ammonium sulfate , with the cell constants a = b = 34 . 3 A and c = 111 . 8 A belonging to space group P3 ( 2 ) 21 .", "entity": [{"entity": "A42D", "entity_type": "GENE", "pos": [30, 34]}, {"entity": "D47P", "entity_type": "GENE", "pos": [37, 41]}, {"entity": "A63L", "entity_type": "GENE", "pos": [44, 48]}], "task": "NER"}
{"text": "Two adjacent , highly homologous endoglucanase genes , celD and celE from Fibrobacter succinogenes S85 , which were separated by an AT - rich 223 - nucleotide intergenic region were characterized .", "entity": [{"entity": "homologous endoglucanase genes", "entity_type": "GENE", "pos": [22, 52]}, {"entity": "celD", "entity_type": "GENE", "pos": [55, 59]}, {"entity": "celE", "entity_type": "GENE", "pos": [64, 68]}], "task": "NER"}
{"text": "Sequence analysis of this region showed it contained five potential copies of the sterol regulatory element ( SRE - 1 ) ( Smith , J . R . , Osborne , T . F . , Brown , M . S . , Goldstein , J . L . , and Gil , G .", "entity": [], "task": "NER"}
{"text": "Toxicity of benzoyl chloride ( 2 , 4 , 6 - trichlorophenyl ) hydrazone ( Banamite ) and potential metabolites to twospotted spider mites and potency as inhibitors of rat liver monoamine oxidase .", "entity": [{"entity": "rat liver monoamine oxidase", "entity_type": "GENE", "pos": [166, 193]}], "task": "NER"}
{"text": "Fetal PaO2 fell somewhat during the recovery stages in both NIT and control groups .", "entity": [], "task": "NER"}
{"text": "It also showed which amino acid residues would contact an extended TATA box with a B recognition element , and evolutionary conservation of the TBP - TFB - DNA complex orientation between two archaeal organisms with widely different optimal temperature for growth ( 37 and 100 degrees C ) .", "entity": [{"entity": "B recognition element", "entity_type": "GENE", "pos": [83, 104]}, {"entity": "TBP", "entity_type": "GENE", "pos": [144, 147]}, {"entity": "TFB", "entity_type": "GENE", "pos": [150, 153]}], "task": "NER"}
{"text": "The average progression was 11 . 6 ( SD 9 . 0 ) .", "entity": [], "task": "NER"}
{"text": "14 . 9 x 109 L - 1 ) was equal for both groups , but CCI values were significantly higher for the bedside filtered PC ( 14 . 1 + / - 9 . 5 vs .", "entity": [], "task": "NER"}
{"text": "Result were as followed : 1 ) Early cancer - like advanced cancers were consisted of 133 lesions , of which 128 lesions ( 96 . 2 % ) had peptic ulcer in cancerous lesion ( 73 lesions were active stage and 55 lesions were scarring stage ) .", "entity": [], "task": "NER"}
{"text": "The median cumulative incidence rates were found to be 341 per million for males and 296 per million for females .", "entity": [], "task": "NER"}
{"text": "The unexpected prevalence of c - myc and alpha - tubulin in the S - phase library is supported by Northern analysis of RNA from phase - synchronous cells .", "entity": [{"entity": "c - myc", "entity_type": "GENE", "pos": [29, 36]}, {"entity": "alpha - tubulin", "entity_type": "GENE", "pos": [41, 56]}], "task": "NER"}
{"text": "A spectrophotometric method for the microdetermination of periodate .", "entity": [], "task": "NER"}
{"text": "Satisfactory correlation was also obtained between the in vivo and the in vitro results .", "entity": [], "task": "NER"}
{"text": "Eleven of the 12 exons have complete sequence homology with the RBM - 1 sequence .", "entity": [{"entity": "RBM - 1 sequence", "entity_type": "GENE", "pos": [64, 80]}], "task": "NER"}
{"text": "Polyoma virus in urine during pregnancy .", "entity": [], "task": "NER"}
{"text": "Using probes from these regions , rearrangements have been identified in each of nine cases of t ( 8 ; 21 ) AML examined .", "entity": [], "task": "NER"}
{"text": "The delta G values of these regions were higher , i . e . potential secondary structural elements were fewer , than in TIR of genes from E . coli .", "entity": [], "task": "NER"}
{"text": "In each patient , MBF was quantified in the three major vascular territories : the left anterior descending and left circumflex coronary artery territories and the right coronary artery ( control region ) territory .", "entity": [], "task": "NER"}
{"text": "Effects of shosaikoto , an oriental herbal medicinal mixture , on restraint - stressed mice .", "entity": [], "task": "NER"}
{"text": "We conclude that 99mTc - HL91 is a potent marker of myocardial viability when used during the early acute phase after reperfusion .", "entity": [], "task": "NER"}
{"text": "Glucose may reduce slightly the pool of amino nitrogen available for albumin and urea synthesis by diverting some of the infused amino acids from protein synthesis by the liver to muscle .", "entity": [{"entity": "albumin", "entity_type": "GENE", "pos": [69, 76]}], "task": "NER"}
{"text": "The community - acquired bacteremia was mainly due to E . coli .", "entity": [], "task": "NER"}
{"text": "The benzo - pyrone drug Venalot had a considerable effect in reducing the protein concentration in the air spaces and the interstitial tissue , and of the oedema in the latter .", "entity": [], "task": "NER"}
{"text": "The brains were bisected and T1 and T2 relaxation times were determined for the right and left hemispheres by MR spectroscopy immediately after dissection .", "entity": [], "task": "NER"}
{"text": "The exact function of IP - 30 is not yet known , but it may play a role in gamma - interferon mediated immune reactions .", "entity": [{"entity": "IP - 30", "entity_type": "GENE", "pos": [22, 29]}, {"entity": "gamma - interferon", "entity_type": "GENE", "pos": [75, 93]}], "task": "NER"}
{"text": "Indeed , ectopic expression of MOX4 in aerobic cells resulted in partially constitutive expression of DAN1 .", "entity": [{"entity": "MOX4", "entity_type": "GENE", "pos": [31, 35]}, {"entity": "DAN1", "entity_type": "GENE", "pos": [102, 106]}], "task": "NER"}
{"text": "Finally , gel shift assays showed that ORF2 was able to bind to promoter fragment 566 - 888 .", "entity": [], "task": "NER"}
{"text": "Mutation of K14 in H3 , which serves as the major target of recombinant Gcn5p acetylation in vitro , confers a strong , synthetic growth defect in gcn5 cells .", "entity": [{"entity": "H3", "entity_type": "GENE", "pos": [19, 21]}, {"entity": "recombinant Gcn5p", "entity_type": "GENE", "pos": [60, 77]}, {"entity": "gcn5", "entity_type": "GENE", "pos": [147, 151]}], "task": "NER"}
{"text": "Histological examination revealed variable loss of motor neurons limited to the injection site .", "entity": [], "task": "NER"}
{"text": "In normal B cells stimulated by LPS or IL - 4 , new complexes appear that bind to C / EBP and NF - IL - 4 elements , respectively , located within the - 125 / - 101 region .", "entity": [{"entity": "IL - 4", "entity_type": "GENE", "pos": [39, 45]}, {"entity": "C / EBP", "entity_type": "GENE", "pos": [82, 89]}, {"entity": "NF - IL - 4 elements", "entity_type": "GENE", "pos": [94, 114]}], "task": "NER"}
{"text": "Phylogenetic analysis using a neighbor - joining algorithm showed closest similarity of the horse mu chain - encoding constant region gene to human and dog sequences .", "entity": [{"entity": "horse mu chain - encoding constant region gene", "entity_type": "GENE", "pos": [92, 138]}], "task": "NER"}
{"text": "Progressive immunodeficiency in a patient with IgA deficiency", "entity": [{"entity": "IgA", "entity_type": "GENE", "pos": [47, 50]}], "task": "NER"}
{"text": "Mouse embryo cells ( C57BL / 6 , H - 2b ) transformed by the E1A and E1B genes of adenovirus type 5 ( Ad5E1 MEC ) are highly immunogenic .", "entity": [{"entity": "E1A", "entity_type": "GENE", "pos": [61, 64]}, {"entity": "E1B", "entity_type": "GENE", "pos": [69, 72]}], "task": "NER"}
{"text": "We hypothesized that subjects would demonstrate PKAR during both hopping and stepping , adding support to the hypothesis that PKAR is a centrally mediated adaptation of general locomotor trajectory that is not specific to the form of locomotion used while on the rotating disk .", "entity": [], "task": "NER"}
{"text": "The major open reading frame of the cDNA predicts a protein of 59 kD , with a leucine zipper situated adjacent to an myc - related motif that has been proposed to assume a helix - loop - helix structure .", "entity": [{"entity": "myc - related motif", "entity_type": "GENE", "pos": [117, 136]}], "task": "NER"}
{"text": "Medical management of early - stage breast cancer .", "entity": [], "task": "NER"}
{"text": "Other Fischer - 344 rats were also exposed for 1 hr to 0 . 0 or to 0 . 6 ppm O3 .", "entity": [], "task": "NER"}
{"text": "Evidence from four areas - - sensory deprivation , enriched environments , nervous system plasticity , and sensitive periods of neurodevelopment - - suggests that sensory stimulation programs are potentially beneficial for STR patients .", "entity": [], "task": "NER"}
{"text": "The limb defects , oligodactyly and syndactyly , have been traced to improper differentiation of the apical ectodermal ridge ( AER ) and shortening of the anteroposterior limb axis .", "entity": [], "task": "NER"}
{"text": "Action against Vibrio cholerae O1 Tox + of chemical products used in the lemon production .", "entity": [{"entity": "Tox +", "entity_type": "GENE", "pos": [34, 39]}], "task": "NER"}
{"text": "Sera collected in 1973 - 1975 from 3053 residents of 12 selected Alaskan Eskimo villages were tested for evidence of hepatitis B virus infection .", "entity": [], "task": "NER"}
{"text": "Donehower and H .", "entity": [], "task": "NER"}
{"text": "We have studied some of the parameters governing the expression of a foreign promoter - reporter gene construct incorporated into herpes simplex virus ( HSV ) type 1 .", "entity": [], "task": "NER"}
{"text": "cDNA cloning reveals two mouse beta5 integrin transcripts distinct in cytoplasmic domains as a result of alternative splicing .", "entity": [{"entity": "mouse beta5 integrin transcripts", "entity_type": "GENE", "pos": [25, 57]}], "task": "NER"}
{"text": "Children with repeated proteinuria during follow - up tend to have a higher incidence of pathologic findings on the i . v . - pyelogram .", "entity": [], "task": "NER"}
{"text": "From the Centers for Disease Control and Prevention .", "entity": [], "task": "NER"}
{"text": "The translated sequence of the FLI LRR associated protein ( FLAP ) encodes a novel protein not represented in the data base .", "entity": [{"entity": "FLI LRR associated protein", "entity_type": "GENE", "pos": [31, 57]}, {"entity": "FLAP", "entity_type": "GENE", "pos": [60, 64]}], "task": "NER"}
{"text": "The analysis of the effects of eight signaling molecules in the TGFbeta , FGF , Hh , Wnt , and EGF families in tooth explant cultures revealed that the expression of edar was induced by activinbetaA , whereas Wnt6 induced ectodysplasin expression .", "entity": [{"entity": "TGFbeta", "entity_type": "GENE", "pos": [64, 71]}, {"entity": "FGF", "entity_type": "GENE", "pos": [74, 77]}, {"entity": "Hh", "entity_type": "GENE", "pos": [80, 82]}, {"entity": "Wnt", "entity_type": "GENE", "pos": [85, 88]}, {"entity": "EGF families", "entity_type": "GENE", "pos": [95, 107]}, {"entity": "edar", "entity_type": "GENE", "pos": [166, 170]}, {"entity": "activinbetaA", "entity_type": "GENE", "pos": [186, 198]}, {"entity": "Wnt6", "entity_type": "GENE", "pos": [209, 213]}, {"entity": "ectodysplasin", "entity_type": "GENE", "pos": [222, 235]}], "task": "NER"}
{"text": "In two separate studies , specimens of saliva from 57 individuals over the age of 65 years ( mean age , 76 . 7 years ) and 37 persons under the age of 40 years ( mean age , 28 . 8 years ) were examined for concentrations of IgA as functions of volume , total protein , and electrolyte conductivity ; some were also tested for IgG and IgM content .", "entity": [{"entity": "IgA", "entity_type": "GENE", "pos": [224, 227]}, {"entity": "IgG", "entity_type": "GENE", "pos": [326, 329]}, {"entity": "IgM", "entity_type": "GENE", "pos": [334, 337]}], "task": "NER"}
{"text": "In the plant malate synthases , the extension is probably involved in routing to the microbodies , since it contains the potential peroxisomal targeting signal , Ser - Arg / Lys - Leu , at the carboxy terminus .", "entity": [{"entity": "plant malate synthases", "entity_type": "GENE", "pos": [7, 29]}], "task": "NER"}
{"text": "These motifs , and their cognate transcription factors , appear to act in concert , with partial redundancy , so that discrete mutations were only partially effective in reducing transcriptional activity .", "entity": [], "task": "NER"}
{"text": "Upon incubation of the most highly purified fractions with Mn - ATP or Mg - ATP , p40 was the only protein phosphorylated on tyrosine .", "entity": [{"entity": "p40", "entity_type": "GENE", "pos": [82, 85]}], "task": "NER"}
{"text": "CLINICAL FEATURES : This 30 - yr - old gravida V para 0 woman presented to the anaesthesia consultation clinic at 37 - wk gestation to discuss pain relief options for labour and delivery .", "entity": [], "task": "NER"}
{"text": "Judge Christian Byk renders service to the Steering Committee on Bioethics of the Council of Europe ( CDBI ) by proposing a draft of the protocol destined to fill in a gap in international law on the status of the human embryo .", "entity": [], "task": "NER"}
{"text": "In agreement with this model , elimination of the ADAM13 cytoplasmic domain increased developmental alterations attributable to ADAM13 proteolytic activity .", "entity": [{"entity": "ADAM13 cytoplasmic domain", "entity_type": "GENE", "pos": [50, 75]}, {"entity": "ADAM13", "entity_type": "GENE", "pos": [128, 134]}], "task": "NER"}
{"text": "Studies in B . glabrata , B . straminea and B . tenagophila under outdoor conditions .", "entity": [], "task": "NER"}
{"text": "E . R . C . P . is an important advance in diagnosis .", "entity": [], "task": "NER"}
{"text": "It also appears that in patients with laboratory diagnosis of prerenal acute renal failure ( i . e . , a RFT less than 1 . 0 ) , the response to treatment is unpredictable and in fact may have a worse prognosis than in those with a RFI greater than 1 . 0 ( 5 / 7 deaths vs 10 / 48 deaths ) .", "entity": [], "task": "NER"}
{"text": "The strangulated intestinal pathologies of horses are accompanied by a local activation of the neutrophils , that can be revealed by measuring the tissular enzymatic activity of the granulocytic enzyme myeloperoxidase ( MPO ) .", "entity": [{"entity": "myeloperoxidase", "entity_type": "GENE", "pos": [202, 217]}, {"entity": "MPO", "entity_type": "GENE", "pos": [220, 223]}], "task": "NER"}
{"text": "The human protein is encoded by a 900 - base pair - long mRNA that is expressed in the glandular epithelial cells of the endometrium in a cyclic manner ; in addition , it is found in the mucosal epithelial cells of the fallopian tubes .", "entity": [], "task": "NER"}
{"text": "The 80 kb preceding the expression site has few , if any , functional ORFs , but contains 50 bp repeats , INGI retrotransposon - like elements , and novel 4 - 12 kb repeats found near other telomeres .", "entity": [{"entity": "INGI retrotransposon - like elements", "entity_type": "GENE", "pos": [106, 142]}], "task": "NER"}
{"text": "Rather than seeking a blanket characterization of an essentially heterogeneous group , it may be more useful to consider idiom comprehension a secondary manifestation of semantic and / or pragmatic difficulties .", "entity": [], "task": "NER"}
{"text": "The two redox centers in the protein , FAD and a [ 4Fe4S ] + 2 , + 1 cluster , are present in a 64 - kDa monomer .", "entity": [], "task": "NER"}
{"text": "The BDU neurons and the ALM touch neurons are lineal sister cells in the AB . a lineage and the VA and VB motor neurons are lineal sister cells in the AB . p lineage .", "entity": [], "task": "NER"}
{"text": "We conclude that a 0 . 25 mg dose of triazolam does not effectively counteract a posture - induced sleep disturbance , but induces changes in the EEG spectra which are typical for benzodiazepine receptor agonists .", "entity": [{"entity": "benzodiazepine receptor", "entity_type": "GENE", "pos": [180, 203]}], "task": "NER"}
{"text": "The biological actions of VHR in oocytes clearly distinguish it from other dual specificity phosphatases , which have shown inhibitory effects when tested in oocytes .", "entity": [{"entity": "VHR", "entity_type": "GENE", "pos": [26, 29]}], "task": "NER"}
{"text": "Discriminant function analysis suggests that AUDIT scores can successfully identify SAT - positive and SAT - negative patients ; the analysis accounted for 42 . 5 % of the variance and correctly classified 84 . 6 % of the sample .", "entity": [], "task": "NER"}
{"text": "Failure to demonstrate a major anti - inflammatory effect with alpha tocopherol supplementation ( 400 IU / day ) in normal subjects .", "entity": [], "task": "NER"}
{"text": "The flanking open reading frames in pARGC2 showed no homologies to arginine biosynthetic genes .", "entity": [], "task": "NER"}
{"text": "Estrogen pretreated castrated males also showed no change in myocardial blood flow after 17 beta - estradiol , but coronary flow velocity decreased ( P < 0 . 05 ) compared with baseline 1 h after the 200 ng / kg dose ( from 1 . 69 + / - 0 . 61 to 1 . 41 + / - 0 . 42 kHz ) and diastolic coronary resistance increased significantly ( P < 0 . 01 ) compared with control at this time ( 51 + / - 15 compared with 39 + / - 14 mmHg / mkHz ) .", "entity": [], "task": "NER"}
{"text": "The studies permit considering the detected shifts in the immunity system an important component of the pathogenesis of chronic nontumorous diseases of the parotid glands .", "entity": [], "task": "NER"}
{"text": "The interaction of different protein systems with microtubules is a critical step in the cellular function of these organelles .", "entity": [], "task": "NER"}
{"text": "Northern blot analysis of liver , muscle , fat , and pituitary RNA from normal ( DwDw ) chickens shows a major transcript of 4 . 3 kilobases ( kb ) and three minor transcripts ( 0 . 8 , 1 . 7 , and 3 . 2 kb ) , which correspond to the cGHR .", "entity": [{"entity": "cGHR", "entity_type": "GENE", "pos": [235, 239]}], "task": "NER"}
{"text": "SHBG concentrations in women were also significantly higher at T - 2 and T - 3 when compared to T - 1 values .", "entity": [{"entity": "SHBG", "entity_type": "GENE", "pos": [0, 4]}], "task": "NER"}
{"text": "Chromosome - specific STSs for 27 telomeres were identified from the 196 TYACs .", "entity": [], "task": "NER"}
{"text": "The patient groups consisted of 31 with dilated cardiomyopathy , 22 with hypertrophic cardiomyopathy , 38 with myocardial infarction , 15 with angina pectoris and 26 with rheumatic valvular disease .", "entity": [], "task": "NER"}
{"text": "The two yeast pheromone receptors , the a and alpha - factor receptors , share many functional similarities : both G protein - coupled receptors couple to the same downstream signal transduction pathway , and both receptors undergo feedback regulation involving increased phosphorylation on their C - terminal domains in response to ligand challenge .", "entity": [{"entity": "yeast pheromone receptors", "entity_type": "GENE", "pos": [8, 33]}, {"entity": "a and alpha - factor receptors", "entity_type": "GENE", "pos": [40, 70]}, {"entity": "G protein - coupled receptors", "entity_type": "GENE", "pos": [115, 144]}], "task": "NER"}
{"text": "Heart rate and oxygen consumption increased 75 + / - 4 bpm and 26 . 3 + / - 1 . 4 ml O2 / kg x min ( - 1 ) from supine resting values , respectively .", "entity": [], "task": "NER"}
{"text": "It also produces an NH2 terminus that corresponds to an equivalent NH2 terminus on the processed matrix form of the similar alpha1 ( XI ) chain , thus suggesting physiological significance .", "entity": [{"entity": "alpha1 ( XI ) chain", "entity_type": "GENE", "pos": [124, 143]}], "task": "NER"}
{"text": "To determine the transactivation potential of each of the four Ahr Sp1 sites , we fused the Ahr promoter to a luciferase ( LUC ) reporter gene and transfected the construct into the Drosophila cell line Schneider - 2 , which contains no Sp1 or Sp1 - like factors .", "entity": [{"entity": "Ahr", "entity_type": "GENE", "pos": [63, 66]}, {"entity": "Sp1 sites", "entity_type": "GENE", "pos": [67, 76]}, {"entity": "Ahr promoter", "entity_type": "GENE", "pos": [92, 104]}, {"entity": "luciferase", "entity_type": "GENE", "pos": [110, 120]}, {"entity": "LUC", "entity_type": "GENE", "pos": [123, 126]}, {"entity": "Sp1", "entity_type": "GENE", "pos": [237, 240]}, {"entity": "Sp1 - like factors", "entity_type": "GENE", "pos": [244, 262]}], "task": "NER"}
{"text": "Based on the results of this analysis , we also predict that the budding yeast arsenate resistance protein Acr2 and the ORF Ygr203w encode protein phosphatases with catalytic properties similar to that of the Cdc25 family .", "entity": [{"entity": "budding yeast arsenate resistance protein", "entity_type": "GENE", "pos": [65, 106]}, {"entity": "Acr2", "entity_type": "GENE", "pos": [107, 111]}, {"entity": "ORF Ygr203w", "entity_type": "GENE", "pos": [120, 131]}, {"entity": "Cdc25 family", "entity_type": "GENE", "pos": [209, 221]}], "task": "NER"}
{"text": "However , in 7 patients with normal CT results the latter method showed areas of cerebral activity anatomically correlated with neurological signs or vascular lesions .", "entity": [], "task": "NER"}
{"text": "Signal transduction in fibroblasts stably transformed by [ Val12 ] Ras - - the activities of extracellular - signal - regulated kinase and Jun N - terminal kinase are only moderately increased , and the activity of the delta - inhibitor of c - Jun is not alleviated .", "entity": [{"entity": "extracellular - signal - regulated kinase", "entity_type": "GENE", "pos": [93, 134]}, {"entity": "Jun N - terminal kinase", "entity_type": "GENE", "pos": [139, 162]}, {"entity": "c - Jun", "entity_type": "GENE", "pos": [240, 247]}], "task": "NER"}
{"text": "Avian EMILIN was extracted from 19 - day - old embryonic chick aortas and associated blood vessels and purified by ion - exchange chromatography and gel filtration .", "entity": [{"entity": "Avian EMILIN", "entity_type": "GENE", "pos": [0, 12]}], "task": "NER"}
{"text": "Asymptomatic ischaemia during daily life in stable coronary artery disease : relevant or redundant ?", "entity": [], "task": "NER"}
{"text": "Individual intolerance to betaxolol will continue to occur and care is always required when patients with cardiac or respiratory dysfunction are exposed to any beta - antagonist .", "entity": [], "task": "NER"}
{"text": "DESIGN : Prospective case study ( Canadian Task Force classification II - 2 ) .", "entity": [], "task": "NER"}
{"text": "The highest incidence was observed for V . alginolyticus ( 92 - 100 % ) , followed by V . parahaemolyticus ( 67 - 92 % ) , V . fluvialis ( 34 - 67 % ) , V . vulnificus ( 8 - 17 % ) , V . furnissii ( 0 - 17 % ) , V . mimicus ( 0 - 17 % ) and V . cholerae non - O1 ( 0 - 8 % ) .", "entity": [], "task": "NER"}
{"text": "Self - consistent calculation of the surface electronic structure of the ( 1 x 2 ) reconstructed Au ( 110 ) surface .", "entity": [], "task": "NER"}
{"text": "In contrast , polypropylene glycol , PG - C , and corn oil all removed 68 - 86 % of the MDI in the first h , 74 - 79 % at 4 h , and 72 - 86 % at 8 h .", "entity": [], "task": "NER"}
{"text": "Peak insulin response to glucose infusion declined from Groups 1 to 3 ( 51 + / - 14 , 42 . 4 + / - 31 , 20 . 4 + / - 6 . 8 microU / ml , respectively ) with Group 3 exhibiting a significantly decreased mean peak level compared to the other groups .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [5, 12]}], "task": "NER"}
{"text": "Chemical structure of antibiotic SF - 837 .", "entity": [], "task": "NER"}
{"text": "Reexamination of the cdc4 - 1 mutant revealed that , in addition to being defective in the onset of S phase , it is also defective in G ( 2 ) / M transition when released from hydroxyurea - induced S - phase arrest .", "entity": [{"entity": "cdc4 - 1 mutant", "entity_type": "GENE", "pos": [21, 36]}], "task": "NER"}
{"text": "Structure and regulation of the luteinizing hormone receptor gene .", "entity": [{"entity": "luteinizing hormone receptor gene", "entity_type": "GENE", "pos": [32, 65]}], "task": "NER"}
{"text": "The procedure was technically successful in 12 of 14 ( 86 % ) stenoses in the fibromuscular dysplasia subgroup but in only one of five ( 20 % ) lesions in the neurofibromatosis subgroup .", "entity": [], "task": "NER"}
{"text": "Amplitude of late surface ( P2 and N2 ) and depth ( B and C ) components significantly decreased when patients shifted from SWS IV to PS and increased from PS to W2 .", "entity": [], "task": "NER"}
{"text": "Unconventional mRNA processing in the expression of two calcineurin B isoforms in Dictyostelium .", "entity": [{"entity": "calcineurin B isoforms", "entity_type": "GENE", "pos": [56, 78]}], "task": "NER"}
{"text": "T1 and T2 values were calculated from guinea pig brain in vivo at 0 . 5 T .", "entity": [], "task": "NER"}
{"text": "A chest - X ray film showed infiltrative shadows in the right middle and lower lung fields , but a chest CT scan showed an abnormal lung density in the right lower lobe .", "entity": [], "task": "NER"}
{"text": "Transcription of the inserted gene into the predicted subgenomic polyadenylated mRNA was demonstrated by Northern ( RNA ) blot hybridization analysis , and the encoded protein was detected by enzyme assay and by radioimmunoprecipitation .", "entity": [], "task": "NER"}
{"text": "We then supplemented these spliceosomes with purified proteins or yeast extract fractions as a functional assay for second - step splicing factors .", "entity": [], "task": "NER"}
{"text": "The severity of the psychomotor retardation varied from mild to severe .", "entity": [], "task": "NER"}
{"text": "Plasma insulin responses to glucose in femoral , hepatic , and pancreatic veins in dogs .", "entity": [{"entity": "Plasma insulin", "entity_type": "GENE", "pos": [0, 14]}], "task": "NER"}
{"text": "The reading achievement of students with learning disabilities who received reading instruction through the DISTAR program was compared to that of similar students using basal reader materials .", "entity": [], "task": "NER"}
{"text": "We discuss the possibility that DNA - protein interactions at homologous nucleotide sequences like those identified in PII are part of a regulatory gene cascade that participates in timing fla gene expression in the C . crescentus cell cycle .", "entity": [{"entity": "fla gene", "entity_type": "GENE", "pos": [189, 197]}], "task": "NER"}
{"text": "Here we demonstrate that a region of high homology between the members of this class of proteins contains a type A nucleotide binding site consensus sequence which has ATPase activity and is sufficient to bind DNA containing specific mismatched residues .", "entity": [{"entity": "ATPase", "entity_type": "GENE", "pos": [168, 174]}], "task": "NER"}
{"text": "The detergent - solubilized complex oxidizes caldariella quinol at high rates and is completely inhibited by cyanide and by quinolone analogs , potent inhibitors of quinol oxidases .", "entity": [{"entity": "quinol oxidases", "entity_type": "GENE", "pos": [165, 180]}], "task": "NER"}
{"text": "Significantly , the murine P - selectin gene had several features not found in the human gene .", "entity": [{"entity": "murine P - selectin gene", "entity_type": "GENE", "pos": [20, 44]}], "task": "NER"}
{"text": "Consistently , we show that phosphorylation by protein kinase A inhibits Sfl1 DNA binding in vitro , and that a tpk2Delta mutation increases the levels of Sfl1 protein associated with specific promoter elements in vivo .", "entity": [{"entity": "protein kinase A", "entity_type": "GENE", "pos": [47, 63]}, {"entity": "Sfl1", "entity_type": "GENE", "pos": [73, 77]}, {"entity": "tpk2Delta", "entity_type": "GENE", "pos": [112, 121]}, {"entity": "Sfl1 protein", "entity_type": "GENE", "pos": [155, 167]}], "task": "NER"}
{"text": "This region was unfavourable , due to malaria in the past .", "entity": [], "task": "NER"}
{"text": "SM binds RNA in vitro , suggesting that sequence - or structure - specific mRNA interactions might mediate SM specificity .", "entity": [{"entity": "SM", "entity_type": "GENE", "pos": [0, 2]}, {"entity": "SM", "entity_type": "GENE", "pos": [107, 109]}], "task": "NER"}
{"text": "Stress - induced suppression of the prolactin afternoon surge in ovariectomized , estrogen - treated rats and the nocturnal surge in pseudopregnant rats are accompanied by an increase in median eminence dihydroxyphenylacetic acid concentrations .", "entity": [{"entity": "prolactin", "entity_type": "GENE", "pos": [36, 45]}], "task": "NER"}
{"text": "In vitro kinase assays on isolated microvilli and microvillar fractions enriched in the putative signal transduction particle showed a high specific activity of tyrosine kinase activity compared to that of membranes from EGF receptor - overexpressing A431 cells maximally activated by EGF .", "entity": [{"entity": "tyrosine kinase", "entity_type": "GENE", "pos": [161, 176]}, {"entity": "EGF receptor", "entity_type": "GENE", "pos": [221, 233]}, {"entity": "EGF", "entity_type": "GENE", "pos": [285, 288]}], "task": "NER"}
{"text": "Among these , four patients had the AIDS syndrome , while 42 individuals were HIV carriers .", "entity": [], "task": "NER"}
{"text": "Carcinogenic action of groundnut meal containing aflatoxin in rats .", "entity": [], "task": "NER"}
{"text": "The UASB reactors treated a VFA mixture ( with an acetate : propionate : butyrate ratio of 5 : 3 : 2 on COD basis ) or acetate as the sole substrate at different COD : sulfate ratios .", "entity": [], "task": "NER"}
{"text": "Lack of changes in milk production and milk composition suggest that acute increases in somatotropin with concomitant increases in insulin are not sufficient to stimulate synthesis of milk and milk components by cows during established lactation .", "entity": [{"entity": "somatotropin", "entity_type": "GENE", "pos": [88, 100]}, {"entity": "insulin", "entity_type": "GENE", "pos": [131, 138]}], "task": "NER"}
{"text": "The initial oral administration of the 1 and 2 mg / kg doses of enoximone improved central hemodynamic parameters with apparent preferential reduction of limb vascular resistance and augmentation of blood flow to the limb region ( peripheral musculoskeletal system ) .", "entity": [], "task": "NER"}
{"text": "Genomic clones containing the C . briggsae gene are able to completely rescue the unc - 119 phenotype in transgenic C . elegans mutants .", "entity": [{"entity": "unc - 119 phenotype", "entity_type": "GENE", "pos": [82, 101]}], "task": "NER"}
{"text": "Copyright 1999 Academic Press .", "entity": [], "task": "NER"}
{"text": "The role of phosphorylation on receptor desensitization was assessed using receptor mutants expressed in COS cells or Chinese hamster lung fibroblasts .", "entity": [], "task": "NER"}
{"text": "For il8ra , it is formed from two exons , whereas for il8rb , seven distinct neutrophil mRNAs are formed by alternative splicing of 11 exons .", "entity": [{"entity": "il8ra", "entity_type": "GENE", "pos": [4, 9]}, {"entity": "il8rb", "entity_type": "GENE", "pos": [54, 59]}], "task": "NER"}
{"text": "The coding sequence of rat MEK kinase 1 ( MEKK1 ) has been determined from multiple , independent cDNA clones .", "entity": [{"entity": "rat MEK kinase 1", "entity_type": "GENE", "pos": [23, 39]}, {"entity": "MEKK1", "entity_type": "GENE", "pos": [42, 47]}], "task": "NER"}
{"text": "By deletion analysis , we identified the regions of c - Jun encoding transformation and transactivation functions .", "entity": [{"entity": "c - Jun", "entity_type": "GENE", "pos": [52, 59]}], "task": "NER"}
{"text": "Several waveforms of both the somatosensory ( N20 , P / N 30 , and P200 ) and the brainstem auditory - evoked response ( I , III , IV , and V ) demonstrated shorter ( p less than 0 . 05 ) latencies in growth - retarded fetuses relative to normal - sized fetuses .", "entity": [], "task": "NER"}
{"text": "The response to nitroglycerin , however , remained intact regardless of initial reperfusion pressure .", "entity": [], "task": "NER"}
{"text": "Interactions were also detected between full - length HSF1 and the small subunit ( gamma ) of TFIIA .", "entity": [{"entity": "HSF1", "entity_type": "GENE", "pos": [54, 58]}, {"entity": "TFIIA", "entity_type": "GENE", "pos": [94, 99]}], "task": "NER"}
{"text": "Pyknotic osteocytes increased at 12 h ( p less than 0 . 01 ) and 2 days ( p less than 0 . 001 ) of ischemia .", "entity": [], "task": "NER"}
{"text": "Northern blot analysis indicated that both human and murine genes encode approximately 6 - kb transcripts .", "entity": [], "task": "NER"}
{"text": "ALT ( alanine aminotransferase ) and Hb ( hemoglobin ) appeared to be predictive for efficacy .", "entity": [{"entity": "ALT", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "alanine aminotransferase", "entity_type": "GENE", "pos": [6, 30]}, {"entity": "Hb", "entity_type": "GENE", "pos": [37, 39]}, {"entity": "hemoglobin", "entity_type": "GENE", "pos": [42, 52]}], "task": "NER"}
{"text": "Maternal behavior was assessed using observational techniques .", "entity": [], "task": "NER"}
{"text": "Effects of timepidium bromide ( TB ; anticholinergic agent ) , acetylcholine ( ACh ) and neostigmine ( Neost ) on gastric and duodenal blood flow distribution were studied by the use of 131I - labeled macroaggregated human serum albumin ( MAA ) in rabbits .", "entity": [{"entity": "MAA", "entity_type": "GENE", "pos": [239, 242]}], "task": "NER"}
{"text": "Nucleotide sequence of the gag gene and gag - pol junction of feline leukemia virus .", "entity": [{"entity": "gag gene", "entity_type": "GENE", "pos": [27, 35]}, {"entity": "gag", "entity_type": "GENE", "pos": [40, 43]}, {"entity": "pol", "entity_type": "GENE", "pos": [46, 49]}], "task": "NER"}
{"text": "When using the high - impedance testing device , the post shock rhythm was initially displayed as ' no signal ' ( Hewlett Packard XL ) or ' asystole ' ( Physio - Control LIFEPAK 9 ) .", "entity": [], "task": "NER"}
{"text": "The plasma steroid levels in the CAPD patients after each infusion rate were equal to or greater than the levels in normal subjects .", "entity": [], "task": "NER"}
{"text": "Nramp2 contains a classical iron responsive element in the 3 ' untranslated region that confers iron dependent mRNA stabilization .", "entity": [{"entity": "Nramp2", "entity_type": "GENE", "pos": [0, 6]}], "task": "NER"}
{"text": "In addition , reduced metabolism to cotinine from the proliposomes and MP was apparently responsible for the sustained plasma nicotine levels .", "entity": [], "task": "NER"}
{"text": "BCR - ABL expression confers cross - resistance to multiple genotoxic anticancer drugs by inhibition of the apoptotic response to DNA damage in association with cell cycle arrest at the G2 - M restriction point .", "entity": [{"entity": "BCR", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "ABL", "entity_type": "GENE", "pos": [6, 9]}], "task": "NER"}
{"text": "When a longer - 714 to + 78 fragment of the PBGD promoter is used , the - 70 GATA mutant still displays erythroid - specific activity and is cis - activated by the 5 ' HS - 2 enhancer , while the - 100 CCACC mutant is completely inactive in the absence or in the presence of the 5 ' HS - 2 enhancer .", "entity": [{"entity": "PBGD promoter", "entity_type": "GENE", "pos": [44, 57]}, {"entity": "5 ' HS - 2 enhancer", "entity_type": "GENE", "pos": [164, 183]}, {"entity": "5 ' HS - 2 enhancer", "entity_type": "GENE", "pos": [279, 298]}], "task": "NER"}
{"text": "Deletion analysis revealed that only the TM domain of E2 was required for Golgi targeting .", "entity": [{"entity": "E2", "entity_type": "GENE", "pos": [54, 56]}], "task": "NER"}
{"text": "In area CA1 of the hippocampus , numbers of normal neurons were increased 11 - to 14 - fold by MK - 801 treatment ( p < 0 . 01 ) .", "entity": [], "task": "NER"}
{"text": "Considering these two facts together , we propose that vasectomy may lead to decrease in the incidence of prostatic tumors - a disease that claims nearly 22 , 000 lives each year in the United States alone .", "entity": [], "task": "NER"}
{"text": "Further studies aim at characterizing the trans - acting factors that mediate the spatial and temporal expression of Hox genes in the developing embryo .", "entity": [{"entity": "Hox genes", "entity_type": "GENE", "pos": [117, 126]}], "task": "NER"}
{"text": "The protein was overexpressed in Escherichia coli and purified to homogeneity .", "entity": [], "task": "NER"}
{"text": "At least one such complex is eliminated by preincubating the nuclear extract with an antibody with broad cross - reactivity with Ets - 1 and Ets - 2 proteins , thus confirming that an ETS transcription factor ( s ) recognizes the - 12 motif .", "entity": [{"entity": "Ets - 1", "entity_type": "GENE", "pos": [129, 136]}, {"entity": "Ets - 2 proteins", "entity_type": "GENE", "pos": [141, 157]}, {"entity": "ETS transcription factor ( s )", "entity_type": "GENE", "pos": [184, 214]}], "task": "NER"}
{"text": "Paraplegia associated with intraaortic balloon pump counterpulsation .", "entity": [], "task": "NER"}
{"text": "Gas exchange was measured breath by breath .", "entity": [], "task": "NER"}
{"text": "BACKGROUND : Peripheral kappa receptor agonists may provide a new therapeutic approach for the treatment of functional dyspepsia .", "entity": [{"entity": "kappa receptor", "entity_type": "GENE", "pos": [24, 38]}], "task": "NER"}
{"text": "Checking for patient compliance , samples ( n = 10 ) with a FK I concentration of 0 ng / mL were re - analyzed .", "entity": [], "task": "NER"}
{"text": "The Robert Wood Johnson Foundation : billion dollar force for health - care change .", "entity": [], "task": "NER"}
{"text": "These results support an in vivo interaction between Nck and CKI - gamma2 and suggest that CKI - gamma2 could be involved in signaling pathways downstream of RTKs .", "entity": [{"entity": "Nck", "entity_type": "GENE", "pos": [53, 56]}, {"entity": "CKI - gamma2", "entity_type": "GENE", "pos": [61, 73]}, {"entity": "CKI - gamma2", "entity_type": "GENE", "pos": [91, 103]}, {"entity": "RTKs", "entity_type": "GENE", "pos": [158, 162]}], "task": "NER"}
{"text": "4 - Hydroxyproline assays were performed to determine collagen content .", "entity": [{"entity": "collagen", "entity_type": "GENE", "pos": [54, 62]}], "task": "NER"}
{"text": "The biological basis for the changes in CNAPs produced by CS2 is under investigation .", "entity": [], "task": "NER"}
{"text": "Non - suppressed thyroidal radioactive iodine uptake ( RAIU ) in thyrotoxic phase in a case of subacute thyroiditis with thyroid - stimulating antibodies ( TSAb ) .", "entity": [], "task": "NER"}
{"text": "Blotting analysis of intestinal RNA and hybridization of the blots with carboxy apoB cDNA probes produced a single 15 - kb hybridization band whereas hybridization with amino terminal probes produced two hybridization bands of 15 and 8 kb .", "entity": [{"entity": "apoB", "entity_type": "GENE", "pos": [80, 84]}], "task": "NER"}
{"text": "The temporal expression of CRAlBP is similar to IRBP while bFGF is not expressed until after photoreceptor differentiation is complete .", "entity": [{"entity": "CRAlBP", "entity_type": "GENE", "pos": [27, 33]}, {"entity": "IRBP", "entity_type": "GENE", "pos": [48, 52]}, {"entity": "bFGF", "entity_type": "GENE", "pos": [59, 63]}], "task": "NER"}
{"text": "Several components in cytokine signaling remain unidentified .", "entity": [], "task": "NER"}
{"text": "Virgin , P .", "entity": [], "task": "NER"}
{"text": "The present report shows that a cis - acting element between - 189 and - 175 bp , which binds thyroid transcription factor - 1 ( TTF - 1 ) , is involved in both activities .", "entity": [{"entity": "thyroid transcription factor - 1", "entity_type": "GENE", "pos": [94, 126]}, {"entity": "TTF - 1", "entity_type": "GENE", "pos": [129, 136]}], "task": "NER"}
{"text": "No universally accepted standardized classification system for acne vulgaris exists , although there is a strong need for it .", "entity": [], "task": "NER"}
{"text": "Constant slowing of median MNCV and SNCV and ulnar SNCV without changes in morphology , amplitude and duration of MAP and SAP have been observed in 92 patients , with persistent abnormalities in 64 cases after six months .", "entity": [], "task": "NER"}
{"text": "Kudzu extract shows potential for moderating alcohol abuse .", "entity": [], "task": "NER"}
{"text": "Serum IgG and IgA level were decreased .", "entity": [{"entity": "IgG", "entity_type": "GENE", "pos": [6, 9]}, {"entity": "IgA", "entity_type": "GENE", "pos": [14, 17]}], "task": "NER"}
{"text": "A novel zinc finger - containing RNA - binding protein conserved from fruitflies to humans .", "entity": [], "task": "NER"}
{"text": "High - affinity binding was also observed with recombinant SH2 domains from v - src and v - fps , raising the possibility of protein - protein interactions between various members of the cytoplasmic PTK family .", "entity": [{"entity": "recombinant SH2 domains", "entity_type": "GENE", "pos": [47, 70]}, {"entity": "v - src", "entity_type": "GENE", "pos": [76, 83]}, {"entity": "v - fps", "entity_type": "GENE", "pos": [88, 95]}, {"entity": "cytoplasmic PTK family", "entity_type": "GENE", "pos": [187, 209]}], "task": "NER"}
{"text": "The M - phase induction activity of Cdc2 - Cdc13 is inhibited by Wee1 tyrosine kinase , which phosphorylates Cdc2 on tyrosine - 15 .", "entity": [{"entity": "Cdc2", "entity_type": "GENE", "pos": [36, 40]}, {"entity": "Cdc13", "entity_type": "GENE", "pos": [43, 48]}, {"entity": "Wee1 tyrosine kinase", "entity_type": "GENE", "pos": [65, 85]}, {"entity": "Cdc2", "entity_type": "GENE", "pos": [109, 113]}], "task": "NER"}
{"text": "Youssoufian , A .", "entity": [], "task": "NER"}
{"text": "Since 1988 Modulit - SZ - 20 has been tested for localization of nephroliths and ureteroliths .", "entity": [], "task": "NER"}
{"text": "Lactate , pyruvate and actual pH values in the venous blood of newborn calves", "entity": [], "task": "NER"}
{"text": "The steady - state levels of Cdk2 , Cdk4 and Cyclin A proteins were unaffected by HPR , while those of Cyclin D1 were significantly reduced in all three cell lines .", "entity": [{"entity": "Cdk2", "entity_type": "GENE", "pos": [29, 33]}, {"entity": "Cdk4", "entity_type": "GENE", "pos": [36, 40]}, {"entity": "Cyclin A proteins", "entity_type": "GENE", "pos": [45, 62]}, {"entity": "Cyclin D1", "entity_type": "GENE", "pos": [103, 112]}], "task": "NER"}
{"text": "The dermatoglyphic pattern demostrates a distal triradius and small whorl abnormalities .", "entity": [], "task": "NER"}
{"text": "The experimental results suggest equilibrium complex formation between OTC and PVP , it being mainly the complex which is i . v . injected when both products are combined in an injection formulation .", "entity": [], "task": "NER"}
{"text": "The MI site is predictive of hemodynamic left ventricular dysfunction both at rest and during exercise : anterior MIs are more impaired than inferior MIs .", "entity": [], "task": "NER"}
{"text": "The median survival time was 18 months .", "entity": [], "task": "NER"}
{"text": "Studies with and without attenuating media were performed , and myocardium - to - defect count ratios and defect sizes from dual - isotope SPECT images were compared to myocardium - to - defect count ratios and defect sizes from single - isotope ( 201Tl and 99mTc ) SPECT images .", "entity": [], "task": "NER"}
{"text": "Biology of Anopheles quadrimaculatus under field conditions in central Florida .", "entity": [], "task": "NER"}
{"text": "This transformation suppression by Rb was further shown to be due to transcriptional repression of neu using Rb expressing effector plasmid and neu promoter - chloramphenicol acetyltransferase reporter gene .", "entity": [{"entity": "Rb", "entity_type": "GENE", "pos": [35, 37]}, {"entity": "neu", "entity_type": "GENE", "pos": [99, 102]}, {"entity": "Rb", "entity_type": "GENE", "pos": [109, 111]}, {"entity": "neu", "entity_type": "GENE", "pos": [144, 147]}, {"entity": "chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [159, 192]}], "task": "NER"}
{"text": "Collectively , a unique mechanism involving NF - ATp appears to regulate the cell type - specific and activation - dependent expression of the SCM - 1 genes .", "entity": [{"entity": "NF - ATp", "entity_type": "GENE", "pos": [44, 52]}, {"entity": "SCM - 1 genes", "entity_type": "GENE", "pos": [143, 156]}], "task": "NER"}
{"text": "In seven patients ( 7 . 8 % ) with new Q - waves and a pathologic CK - MB profile ( group II ) troponin T reached median levels of 10 . 47 micrograms / l ( quartile 6 . 34 - 12 . 50 micrograms / l ) ( P < 0 . 001 I vs II ) .", "entity": [{"entity": "CK - MB", "entity_type": "GENE", "pos": [66, 73]}, {"entity": "troponin T", "entity_type": "GENE", "pos": [95, 105]}], "task": "NER"}
{"text": "EMG - based measures of fatigue during a repetitive squat exercise .", "entity": [], "task": "NER"}
{"text": "CONCLUSIONS : The results show that intranasal challenge with FLU induces changes in leukocyte histamine release , but not other systemic immune and inflammatory responses .", "entity": [], "task": "NER"}
{"text": "Southern blot analysis revealed that CCaMK is encoded by a single gene .", "entity": [{"entity": "CCaMK", "entity_type": "GENE", "pos": [37, 42]}], "task": "NER"}
{"text": "The gamma - GCS gene is expressed ubiquitously and induced coordinately with NAD ( P ) H : quinone oxidoreductase ( 1 ) ( NQO1 ) and glutathione S - transferase Ya ( GST Ya ) in response to xenobiotics and antioxidants .", "entity": [{"entity": "gamma - GCS gene", "entity_type": "GENE", "pos": [4, 20]}, {"entity": "NAD ( P ) H : quinone oxidoreductase ( 1 )", "entity_type": "GENE", "pos": [77, 119]}, {"entity": "NQO1", "entity_type": "GENE", "pos": [122, 126]}, {"entity": "glutathione S - transferase Ya", "entity_type": "GENE", "pos": [133, 163]}, {"entity": "GST Ya", "entity_type": "GENE", "pos": [166, 172]}], "task": "NER"}
{"text": "A fine - structure radiation hybrid map for the region that extends from D8S520 ( distal ) to D8S1759 ( proximal ) was prepared , followed by construction of a single , integrated YAC / BAC contig for the interval .", "entity": [{"entity": "D8S520", "entity_type": "GENE", "pos": [73, 79]}, {"entity": "D8S1759", "entity_type": "GENE", "pos": [94, 101]}], "task": "NER"}
{"text": "The N1 - P2 amplitudes of the AEP decreased with increasing strength of muscular innervation .", "entity": [], "task": "NER"}
{"text": "Measurements in rats given a dose of propranolol that partially inhibited the NA - induced increase in Q to IBAT indicated that the decline in ENAIBAT was attributable primarily to the increase in Q rather than to increasing saturation of uptake mechanisms .", "entity": [], "task": "NER"}
{"text": "Messenger RNA for the Ad2 DNA binding protein : DNA sequences encoding the first leader and heterogenity at the mRNA 5 ' end .", "entity": [{"entity": "Ad2 DNA binding protein", "entity_type": "GENE", "pos": [22, 45]}], "task": "NER"}
{"text": "All rights reserved .", "entity": [], "task": "NER"}
{"text": "These results were not obtained using either preimmune sera or antiserum specific for the luminal portion of the glycoprotein precursor .", "entity": [], "task": "NER"}
{"text": "The yeast genome contains a single ORD1 gene that resides on chromosome XI .", "entity": [{"entity": "ORD1 gene", "entity_type": "GENE", "pos": [35, 44]}], "task": "NER"}
{"text": "HNF4alpha7 mRNA is also found in totipotent embryonic stem cells .", "entity": [{"entity": "HNF4alpha7 mRNA", "entity_type": "GENE", "pos": [0, 15]}], "task": "NER"}
{"text": "Northern ( RNA ) blot hybridization analysis with the p68c - ets - 1 - specific sequence and RNase protection experiments showed that the corresponding mRNA was expressed in normal chicken spleen and not in normal chicken thymus or in various T lymphoid cell lines .", "entity": [{"entity": "p68c - ets - 1", "entity_type": "GENE", "pos": [54, 68]}, {"entity": "RNase", "entity_type": "GENE", "pos": [93, 98]}], "task": "NER"}
{"text": "The fz - 1 and fz - 2 genes are widely expressed in rat tissues with the highest steady - state levels of mRNA in kidney , liver , heart , uterus , and ovary . fz - 1 and - 2 mRNA levels were greater in neonatal than in corresponding adult tissues .", "entity": [{"entity": "fz - 1", "entity_type": "GENE", "pos": [4, 10]}, {"entity": "fz - 2 genes", "entity_type": "GENE", "pos": [15, 27]}, {"entity": "fz - 1 and - 2 mRNA", "entity_type": "GENE", "pos": [160, 179]}], "task": "NER"}
{"text": "We carried out two experiments to investigate this problem .", "entity": [], "task": "NER"}
{"text": "Mean concentration of insulin in maternal plasma across all sampling times was higher in ethanol treated animals .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [22, 29]}], "task": "NER"}
{"text": "Steady - state levels of murine MMR mRNA were measured in the macrophage cell line J774E , which is known to express the protein at the cell surface .", "entity": [{"entity": "murine MMR mRNA", "entity_type": "GENE", "pos": [25, 40]}], "task": "NER"}
{"text": "In this work , we have used Xenopus oocyte maturation as a read - out for examining the ability of the neu tyrosine kinase ( p185neu ) to participate with the epidermal growth factor ( EGF ) receptor in a common signal transduction pathway .", "entity": [{"entity": "neu", "entity_type": "GENE", "pos": [103, 106]}, {"entity": "tyrosine kinase", "entity_type": "GENE", "pos": [107, 122]}, {"entity": "p185neu", "entity_type": "GENE", "pos": [125, 132]}, {"entity": "epidermal growth factor ( EGF ) receptor", "entity_type": "GENE", "pos": [159, 199]}], "task": "NER"}
{"text": "Triaxiality in the proton - neutron interacting boson model : Perturbed O ( 6 ) symmetry with application to the mass A", "entity": [], "task": "NER"}
{"text": "Role of distinct mitogen - activated protein kinase pathways and cooperation between Ets - 2 , ATF - 2 , and Jun family members in human urokinase - type plasminogen activator gene induction by interleukin - 1 and tetradecanoyl phorbol acetate .", "entity": [{"entity": "mitogen - activated protein kinase", "entity_type": "GENE", "pos": [17, 51]}, {"entity": "Ets - 2", "entity_type": "GENE", "pos": [85, 92]}, {"entity": "ATF - 2", "entity_type": "GENE", "pos": [95, 102]}, {"entity": "Jun family members", "entity_type": "GENE", "pos": [109, 127]}, {"entity": "human urokinase - type plasminogen activator gene", "entity_type": "GENE", "pos": [131, 180]}, {"entity": "interleukin - 1", "entity_type": "GENE", "pos": [194, 209]}], "task": "NER"}
{"text": "Comparative volumetric analysis is defined as the difference between mean corpuscular erythrocyte volume in peripheral blood ( MCVB ) diluted in urine supernatant after centrifugation and mean corpuscular volume of urinary erythrocytes ( MCVU ) .", "entity": [], "task": "NER"}
{"text": "To assess whether thallium - 201 thallous chloride ( Tl ) can detect childhood tumors and whether diagnostic effectiveness improves with combined blood flow imaging , 28 children ( 1 . 0 - 18 . 6 years ) were studied using single photon emission computed tomography ( SPECT ) : Tl ( 1 . 3 - 1 . 8 mCi intravenously ) , followed in 13 of the patients by technetium - 99m - hexamethylpropyleneamine oxime ( 99mTc - HMPAO ; 8 - 18 mCi intravenously ) .", "entity": [], "task": "NER"}
{"text": "The role of NUT1 and regulation of nitrogen metabolism in the disease process was evaluated by pathogenicity assays .", "entity": [{"entity": "NUT1", "entity_type": "GENE", "pos": [12, 16]}], "task": "NER"}
{"text": "Analysis of tobacco mRNA using the ACBF cDNA as probe showed that while ACBF mRNA was present in all tissues examined , the highest transcript accumulation occurred in stem tissues .", "entity": [{"entity": "ACBF cDNA", "entity_type": "GENE", "pos": [35, 44]}, {"entity": "ACBF mRNA", "entity_type": "GENE", "pos": [72, 81]}], "task": "NER"}
{"text": "When PCR was used to amplify agar cultures which do not express the fimbriae , the switch region was OFF only .", "entity": [], "task": "NER"}
{"text": "We therefore investigated whether the promoter activity of the mouse TRH gene is directly regulated by RA using a transient transfection assay into CV - 1 cells .", "entity": [{"entity": "mouse TRH gene", "entity_type": "GENE", "pos": [63, 77]}], "task": "NER"}
{"text": "This study tests the hypothesis that O2 is a critical component in myocardial protection afforded by BCP .", "entity": [], "task": "NER"}
{"text": "Sin4 and Srb10 , components of specific RNA polymerase II sub - complexes that are required for Ssn6 - Tup1 repression activity , are found to be required for Sfl1 repression function .", "entity": [{"entity": "Sin4", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "Srb10", "entity_type": "GENE", "pos": [9, 14]}, {"entity": "RNA polymerase II sub - complexes", "entity_type": "GENE", "pos": [40, 73]}, {"entity": "Ssn6", "entity_type": "GENE", "pos": [96, 100]}, {"entity": "Tup1", "entity_type": "GENE", "pos": [103, 107]}, {"entity": "Sfl1", "entity_type": "GENE", "pos": [159, 163]}], "task": "NER"}
{"text": "Functional PET scanning in the preoperative assessment of cerebral arteriovenous malformations .", "entity": [], "task": "NER"}
{"text": "The MEE was significantly greater than the BEE and significantly less than the calculated energy expenditure .", "entity": [], "task": "NER"}
{"text": "Differences were not found in colons by SEM .", "entity": [], "task": "NER"}
{"text": "Consistent with this , rh5 expression in R8 disappears when R7 cells are absent ( in sevenless mutant ) .", "entity": [{"entity": "rh5", "entity_type": "GENE", "pos": [23, 26]}, {"entity": "R8", "entity_type": "GENE", "pos": [41, 43]}, {"entity": "sevenless mutant", "entity_type": "GENE", "pos": [85, 101]}], "task": "NER"}
{"text": "The human RIL gene : mapping to human chromosome 5q31 . 1 , genomic organization and alternative transcripts .", "entity": [{"entity": "RIL gene", "entity_type": "GENE", "pos": [10, 18]}], "task": "NER"}
{"text": "These findings indicated that p35 is a trans - dominant factor that facilitates AcMNPV growth in a cell line - specific manner .", "entity": [{"entity": "p35", "entity_type": "GENE", "pos": [30, 33]}], "task": "NER"}
{"text": "We found remarkable differences in the expression patterns of MTB - Zf mRNA and two other hybridizable mRNAs of 5kb and 8 . 5 kb when human brain and primary brain tumors were compared .", "entity": [{"entity": "MTB - Zf mRNA", "entity_type": "GENE", "pos": [62, 75]}], "task": "NER"}
{"text": "We have recently shown that induced expression of a CDK target site - deficient mutant , Op18 - S25A , S38A , blocks human cell lines during G2 / M transition .", "entity": [{"entity": "CDK", "entity_type": "GENE", "pos": [52, 55]}, {"entity": "Op18", "entity_type": "GENE", "pos": [89, 93]}], "task": "NER"}
{"text": "ATF6 , a basic - leucine zipper protein , was isolated by binding to SRF and in particular to its transcriptional activation domain .", "entity": [{"entity": "ATF6", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "basic - leucine zipper protein", "entity_type": "GENE", "pos": [9, 39]}, {"entity": "SRF", "entity_type": "GENE", "pos": [69, 72]}], "task": "NER"}
{"text": "An ICU length of stay shorter than 24 h was not related to the frequency of group C errors .", "entity": [], "task": "NER"}
{"text": "Primers were developed for specific amplification of 9804 gene fragments .", "entity": [{"entity": "9804 gene fragments", "entity_type": "GENE", "pos": [53, 72]}], "task": "NER"}
{"text": "These results demonstrate that GGTase - I inhibitors arrest cells in G0 / G1 and induce accumulation of p21WAF in a p53 - independent manner and that FTase inhibitors can interfere with cell cycle events by a mechanism that involves neither p21WAF nor p27KIP .", "entity": [{"entity": "GGTase - I", "entity_type": "GENE", "pos": [31, 41]}, {"entity": "p21WAF", "entity_type": "GENE", "pos": [104, 110]}, {"entity": "p53", "entity_type": "GENE", "pos": [116, 119]}, {"entity": "FTase", "entity_type": "GENE", "pos": [150, 155]}, {"entity": "p21WAF", "entity_type": "GENE", "pos": [241, 247]}, {"entity": "p27KIP", "entity_type": "GENE", "pos": [252, 258]}], "task": "NER"}
{"text": "These results provide strong evidence that conserved interhelical packing interactions in the gp41 core are important determinants of HIV - 1 entry and its inhibition .", "entity": [{"entity": "gp41 core", "entity_type": "GENE", "pos": [94, 103]}], "task": "NER"}
{"text": "Thus , CR2 possesses an essential function besides pRb - binding .", "entity": [{"entity": "CR2", "entity_type": "GENE", "pos": [7, 10]}, {"entity": "pRb", "entity_type": "GENE", "pos": [51, 54]}], "task": "NER"}
{"text": "Injection of horseradish peroxidase ( HRP ) into the cerebellar flocculus of the rat was employed to identify neurons in the abducens nucleus that project to the flocculus .", "entity": [{"entity": "horseradish peroxidase", "entity_type": "GENE", "pos": [13, 35]}, {"entity": "HRP", "entity_type": "GENE", "pos": [38, 41]}], "task": "NER"}
{"text": "Natl .", "entity": [], "task": "NER"}
{"text": "In contrast , NF - kappa B activation was observed in these cells after PMA stimulation .", "entity": [{"entity": "NF - kappa B", "entity_type": "GENE", "pos": [14, 26]}], "task": "NER"}
{"text": "From our own investigations on phantoms , the smallest signal - to - noise ratio ( delta S min / delta R ) was obtained which determines the minimal contrast , given the film properties ( film response S , film gradient gamma ) and the amount of scatter .", "entity": [], "task": "NER"}
{"text": "It encodes a sequence - specific transcription factor that controls , in concert with other gene products , differentiative pathways of tissues in which Scr is expressed .", "entity": [{"entity": "Scr", "entity_type": "GENE", "pos": [153, 156]}], "task": "NER"}
{"text": "We functionally characterised AtXPO1 by its interaction with NESs of animal and plant proteins , which is inhibited by the cytotoxin leptomycin B ( LMB ) , and also by its interaction with the small GTPase Ran1 in the yeast two - hybrid system .", "entity": [{"entity": "AtXPO1", "entity_type": "GENE", "pos": [30, 36]}, {"entity": "small GTPase", "entity_type": "GENE", "pos": [193, 205]}, {"entity": "Ran1", "entity_type": "GENE", "pos": [206, 210]}], "task": "NER"}
{"text": "The use of self - measured blood pressure determinations in assessing dynamics of drug compliance in a study with amlodipine once a day , morning versus evening .", "entity": [], "task": "NER"}
{"text": "The enzyme encoded by the cloned fragment is equally active on pyruvate and hydroxypyruvate , indicating that the enzyme has both D - lactate and D - glycerate dehydrogenase activities .", "entity": [{"entity": "D - lactate and D - glycerate dehydrogenase", "entity_type": "GENE", "pos": [130, 173]}], "task": "NER"}
{"text": "We propose that unc - 37 may be regulated by unc - 4 .", "entity": [{"entity": "unc - 37", "entity_type": "GENE", "pos": [16, 24]}, {"entity": "unc - 4", "entity_type": "GENE", "pos": [45, 52]}], "task": "NER"}
{"text": "The gag - myc proteins encoded by these variants efficiently localized to the cell nucleus .", "entity": [{"entity": "gag", "entity_type": "GENE", "pos": [4, 7]}, {"entity": "myc", "entity_type": "GENE", "pos": [10, 13]}], "task": "NER"}
{"text": "From the supposition that there exists a possible connection between certain psychopathological symptoms , and / or syndromes ( e . g . , hallucinations ) and regional cerebral dysfunction , patients suffering from auditory and tactile hallucinations were investigated , in a symptom - oriented study , using the method of technetium - 99m - Hexamethyl - propylenamine Oxime ( 99m - Tc - HMPAO ) - Single Photon Emission Computed Tomography ( SPECT ) and compared with normal controls .", "entity": [], "task": "NER"}
{"text": "The encoded 260 - amino - acid ( aa ) ( H1 - I ) and 240 - aa ( H1 - II ) polypeptides possess the typical tripartite organization of animal H1 histones , with variable N - and C - terminal domains flanking a conserved ' globular ' DNA - binding domain .", "entity": [{"entity": "260 - amino - acid ( aa ) ( H1 - I )", "entity_type": "GENE", "pos": [12, 48]}, {"entity": "240 - aa ( H1 - II ) polypeptides", "entity_type": "GENE", "pos": [53, 86]}, {"entity": "animal H1 histones", "entity_type": "GENE", "pos": [134, 152]}], "task": "NER"}
{"text": "The best - studied neurotrophin , nerve growth factor ( NGF ) , is a major survival factor in sympathetic and sensory neurons and promotes differentiation in a well - studied model system , PC12 cells .", "entity": [{"entity": "nerve growth factor", "entity_type": "GENE", "pos": [34, 53]}, {"entity": "NGF", "entity_type": "GENE", "pos": [56, 59]}], "task": "NER"}
{"text": "In a subsequent phase - II clinical trial safety and efficacy of transrectal HIFU as a novel minimally invasive treatment modality for patients with symptomatic benign prostatic hyperplasia ( BPH ; n = 102 ) was determined .", "entity": [], "task": "NER"}
{"text": "A novel alternative spliced variant of the transcription factor AP2alpha is expressed in the murine ocular lens .", "entity": [{"entity": "AP2alpha", "entity_type": "GENE", "pos": [64, 72]}], "task": "NER"}
{"text": "CONCLUSION : high resolution MF - ERG seems more sensitive than low resolution MF - ERG .", "entity": [], "task": "NER"}
{"text": "The residual small rRNAs in [ poky ] appear to be synthesized via the upstream promoter ( s ) , but are missing 37 - 44 nucleotides from their 5 ' ends , indicating either that pre - rRNAs are processed abnormally or that abnormal 5 ' RNA ends are unstable .", "entity": [], "task": "NER"}
{"text": "Homology is much higher ( 64 % ) between the 28 - kDa protein and regions that are strongly conserved among the members of the serine protease family .", "entity": [{"entity": "serine protease family", "entity_type": "GENE", "pos": [127, 149]}], "task": "NER"}
{"text": "In contrast , inactivation of the Sir4p - interacting protein Rap1p reduces partitioning by a LexA - Sir4p fusion .", "entity": [{"entity": "Sir4p - interacting protein Rap1p", "entity_type": "GENE", "pos": [34, 67]}, {"entity": "LexA", "entity_type": "GENE", "pos": [94, 98]}, {"entity": "Sir4p", "entity_type": "GENE", "pos": [101, 106]}], "task": "NER"}
{"text": "Childbirth and authoritative knowledge .", "entity": [], "task": "NER"}
{"text": "Thus , the end of a linearized DNA fragment can initiate new DNA synthesis by BIR in which the newly synthesized DNA is displaced and subsequently forms circles by NHEJ .", "entity": [], "task": "NER"}
{"text": "The relationship between polymorphonuclear granulocytes and cartilage destruction in rheumatoid arthritis .", "entity": [], "task": "NER"}
{"text": "From the deduced amino acid sequence , a molecular weight of 38 , 549 was calculated for the ADH subunit .", "entity": [{"entity": "ADH subunit", "entity_type": "GENE", "pos": [93, 104]}], "task": "NER"}
{"text": "Nine months after the end of the vaccination anti - HBsAg levels had dropped to 9 + / - 4 IU / 1 ( M + / - SE ) , with a geometric mean of 5 IU / 1 , in the nine remaining evaluable patients .", "entity": [{"entity": "anti - HBsAg", "entity_type": "GENE", "pos": [45, 57]}], "task": "NER"}
{"text": "The point mutation Asp - 316 - - > Asn in the C - terminus of p38 , analogous to the ERK2 ( extracellular - signal - regulated kinase 2 ) sevenmaker mutation , dramatically decreases its binding to MKP - 1 and substantially compromises its stimulatory effect on the catalytic activity of this phosphatase .", "entity": [{"entity": "p38", "entity_type": "GENE", "pos": [62, 65]}, {"entity": "ERK2", "entity_type": "GENE", "pos": [85, 89]}, {"entity": "extracellular - signal - regulated kinase 2", "entity_type": "GENE", "pos": [92, 135]}, {"entity": "sevenmaker", "entity_type": "GENE", "pos": [138, 148]}, {"entity": "MKP - 1", "entity_type": "GENE", "pos": [198, 205]}], "task": "NER"}
{"text": "Cortical somatosensory evoked potentials to median nerve stimulation revealed significantly delayed peak latencies of N20 , P20 , P25 , and N26 , although N16 latency was normal .", "entity": [], "task": "NER"}
{"text": "Catalase plays a key role as an antioxidant , protecting aerobic organisms from the toxic effects of hydrogen peroxide , and in some cases has been postulated to be a virulence factor .", "entity": [{"entity": "Catalase", "entity_type": "GENE", "pos": [0, 8]}], "task": "NER"}
{"text": "Prazosin in the treatment of high blood pressure", "entity": [], "task": "NER"}
{"text": "The results suggest that proenzyme processing is not essential for secretion of PC2 , but peptides containing mutations that affect the ability of the propeptide ( and cleavage sites ) to fold within the catalytic pocket are not transferred beyond the early stages of the secretory pathway .", "entity": [{"entity": "PC2", "entity_type": "GENE", "pos": [80, 83]}], "task": "NER"}
{"text": "Cloning , sequence analysis , and expression of the gene encoding formaldehyde dismutase from Pseudomonas putida F61 .", "entity": [{"entity": "gene encoding formaldehyde dismutase from Pseudomonas putida F61", "entity_type": "GENE", "pos": [52, 116]}], "task": "NER"}
{"text": "Taking into account certain well defined conditions ( frequent feedings , no supplementary feeding before 4 - 6 months , method only to be used in the absence of menstruation ) , LAM can be relied on for contraceptive protection for up to 1 year post partum .", "entity": [], "task": "NER"}
{"text": "The bioconversion of penicillin G , an inexpensive substrate , to the valuable intermediate for semisynthetic cephalosporin production , deacetoxycephalosporin G ( DAOG ) , had been recently shown to be increased by eliminating agitation and adding decane .", "entity": [], "task": "NER"}
{"text": "Doctors given intrathecal methotrexate had headache when 20 gauge standard needle was used .", "entity": [], "task": "NER"}
{"text": "The IGFBP - 1 IRS and PEPCK IRS both bind the alpha and beta forms of hepatic nuclear factor 3 ( HNF - 3 ) , although the latter does so with a sixfold - lower relative affinity .", "entity": [{"entity": "IGFBP - 1", "entity_type": "GENE", "pos": [4, 13]}, {"entity": "IRS", "entity_type": "GENE", "pos": [14, 17]}, {"entity": "PEPCK", "entity_type": "GENE", "pos": [22, 27]}, {"entity": "IRS", "entity_type": "GENE", "pos": [28, 31]}, {"entity": "hepatic nuclear factor 3", "entity_type": "GENE", "pos": [70, 94]}, {"entity": "HNF - 3", "entity_type": "GENE", "pos": [97, 104]}], "task": "NER"}
{"text": "Free protein S deficiency in acute ischemic stroke .", "entity": [{"entity": "protein S", "entity_type": "GENE", "pos": [5, 14]}], "task": "NER"}
{"text": "Low - affinity E2 - binding site mediates downmodulation of E2 transactivation of the human papillomavirus type 8 late promoter .", "entity": [{"entity": "E2 - binding site", "entity_type": "GENE", "pos": [15, 32]}, {"entity": "E2", "entity_type": "GENE", "pos": [60, 62]}, {"entity": "human papillomavirus type 8 late promoter", "entity_type": "GENE", "pos": [86, 127]}], "task": "NER"}
{"text": "This domain encompasses the region of ARP - 1 / COUP - TFII corresponding to helices 3 to 12 in the recently published crystal structure of other members of the nuclear receptor superfamily .", "entity": [{"entity": "ARP - 1", "entity_type": "GENE", "pos": [38, 45]}, {"entity": "COUP - TFII", "entity_type": "GENE", "pos": [48, 59]}, {"entity": "nuclear receptor superfamily", "entity_type": "GENE", "pos": [161, 189]}], "task": "NER"}
{"text": "Our data suggest that the ZF - HD class of homeodomain proteins may be involved in the establishment of the characteristic expression pattern of the C4 PEPCase gene .", "entity": [{"entity": "ZF - HD", "entity_type": "GENE", "pos": [26, 33]}, {"entity": "homeodomain proteins", "entity_type": "GENE", "pos": [43, 63]}, {"entity": "C4 PEPCase gene", "entity_type": "GENE", "pos": [149, 164]}], "task": "NER"}
{"text": "When medical aid was sought a false history was given and the true nature of the child ' s illness , heat stroke , was not determined until after death .", "entity": [], "task": "NER"}
{"text": "BACKGROUND .", "entity": [], "task": "NER"}
{"text": "To test the role of myb family members in progression through the cell cycle , we comicroinjected c - myc and myb expression vectors into serum - deprived quiescent SMCs .", "entity": [{"entity": "myb family members", "entity_type": "GENE", "pos": [20, 38]}, {"entity": "c - myc", "entity_type": "GENE", "pos": [98, 105]}, {"entity": "myb", "entity_type": "GENE", "pos": [110, 113]}], "task": "NER"}
{"text": "Previous studies have shown that the IME1 gene is required for sporulation and the expression of meiosis specific genes in Saccharomyces cerevisiae .", "entity": [{"entity": "IME1 gene", "entity_type": "GENE", "pos": [37, 46]}], "task": "NER"}
{"text": "Cytogenetic structures showed a mixte karyotype : mosaicim 46 XX / 46 XY with a ratio of a 80 / 20 .", "entity": [], "task": "NER"}
{"text": "CONCLUSION : Ultrasound biomicroscopy is a useful tool for the evaluation of APVR , which is difficult by ordinary methods .", "entity": [], "task": "NER"}
{"text": "Morphological - functional status of the edentulous mandible and selection of the most effective method for functional impression - taking", "entity": [], "task": "NER"}
{"text": "Eight of the 17 seropositive patients failed to develop detectable hepatitis B surface antibody within three months of the third injection compared with only one of the 18 seronegative patients ( p less than 0 . 01 ) .", "entity": [{"entity": "hepatitis B surface antibody", "entity_type": "GENE", "pos": [67, 95]}], "task": "NER"}
{"text": "Like the human gene , the Drosophila gene encodes at least three isoforms of full length dystrophin - like proteins ( dmDLP1 , dmDLP2 and dmDLP3 , ) , regulated by different promoters located at the 5 ' end of the gene , and a smaller product regulated by an internal promoter ( dmDp186 ) .", "entity": [{"entity": "full length dystrophin - like proteins", "entity_type": "GENE", "pos": [77, 115]}, {"entity": "dmDLP1", "entity_type": "GENE", "pos": [118, 124]}, {"entity": "dmDLP2", "entity_type": "GENE", "pos": [127, 133]}, {"entity": "dmDLP3", "entity_type": "GENE", "pos": [138, 144]}, {"entity": "dmDp186", "entity_type": "GENE", "pos": [279, 286]}], "task": "NER"}
{"text": "In this study , the case of a patient presenting a second hepatocellular carcinoma 13 years after resection of a first tumor of the same type is reported .", "entity": [], "task": "NER"}
{"text": "The equation for mean trabecular number passed the test , whereas the validity of the equations for mean trabecular separation and Tb . Wi appeared limited .", "entity": [], "task": "NER"}
{"text": "Although the only authoritative way to determine the effect of diet on urinary pH is a feeding trial , there is no universally accepted protocol for measuring urinary pH .", "entity": [], "task": "NER"}
{"text": "The performances of two tests , the ProstAsure index and the percent free PSA test , were evaluated in detecting cancer .", "entity": [{"entity": "PSA", "entity_type": "GENE", "pos": [74, 77]}], "task": "NER"}
{"text": "But if one equalizes the upper limits of normal for both markers to a common 95 % specificity , the tumour - indicating sensitivity of CA 19 - 9 clearly surpasses that of CA 50 .", "entity": [{"entity": "CA 19 - 9", "entity_type": "GENE", "pos": [135, 144]}, {"entity": "CA 50", "entity_type": "GENE", "pos": [171, 176]}], "task": "NER"}
{"text": "For economical reasons , we could not send a questionnaire to all the 35 , 779 individuals , but based the investigation on a SRS of 4 , 000 men , post - stratified in a high - risk and a low - risk group .", "entity": [], "task": "NER"}
{"text": "Thus , over a wide range of arterial dimensions , results obtained with caliper estimates of luminal area and diameter are comparable to those obtained with videodensitometry using the XR - 70 system .", "entity": [], "task": "NER"}
{"text": "Oncogenic activation of RET is detected in human papillary thyroid tumours and in multiple endocrine neoplasia type 2 syndromes .", "entity": [{"entity": "RET", "entity_type": "GENE", "pos": [24, 27]}], "task": "NER"}
{"text": "Evasion of host immunity by Toxocara canis infective larvae is mediated by the nematode surface coat , which is shed in response to binding by host antibody molecules or effector cells .", "entity": [], "task": "NER"}
{"text": "These data show that the processing of specific target transcripts , such as the P - element mRNA , is regulated by a functional PSI - U1 snRNP interaction in Drosophila .", "entity": [{"entity": "P - element mRNA", "entity_type": "GENE", "pos": [81, 97]}, {"entity": "PSI", "entity_type": "GENE", "pos": [129, 132]}, {"entity": "U1", "entity_type": "GENE", "pos": [135, 137]}], "task": "NER"}
{"text": "The predicted proteins show strong homology to an ABA - inducible glycine - rich protein from maize embryos and to the mammalian RNA - binding protein A1 of the heterogeneous nuclear ribonucleoprotein complex involved in pre - mRNA splicing .", "entity": [{"entity": "ABA - inducible glycine - rich protein", "entity_type": "GENE", "pos": [50, 88]}, {"entity": "mammalian RNA - binding protein A1", "entity_type": "GENE", "pos": [119, 153]}], "task": "NER"}
{"text": "Ptx1 belongs to an expanding family of bicoid - related vertebrate homeobox genes .", "entity": [{"entity": "Ptx1", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "bicoid - related", "entity_type": "GENE", "pos": [39, 55]}], "task": "NER"}
{"text": "Reactive mesothelial cells , usually seen as exfoliated cells , were consistently strongly positive for alpha 1 - antichymotrypsin and more variably for alpha 1 - antitrypsin and lysozyme .", "entity": [{"entity": "alpha 1 - antichymotrypsin", "entity_type": "GENE", "pos": [104, 130]}, {"entity": "alpha 1 - antitrypsin", "entity_type": "GENE", "pos": [153, 174]}, {"entity": "lysozyme", "entity_type": "GENE", "pos": [179, 187]}], "task": "NER"}
{"text": "However , all pathophysiologic assessments reported to date have been carried out during or immediately after IVOX utilization .", "entity": [], "task": "NER"}
{"text": "The wet and dry methods of the HA synthesis are considered .", "entity": [], "task": "NER"}
{"text": "In agreement with other authors , we recommend the procedure as a safe one , providing satisfactory results .", "entity": [], "task": "NER"}
{"text": "In several steps we converted the retinoid specific response element of the human retinoic acid receptor beta promoter into the vitamin D / retinoic acid response element of the human osteocalcin promoter .", "entity": [{"entity": "human retinoic acid receptor beta promoter", "entity_type": "GENE", "pos": [76, 118]}, {"entity": "human osteocalcin promoter", "entity_type": "GENE", "pos": [178, 204]}], "task": "NER"}
{"text": "Our data define Ile ( 16 ) , Val ( 18 ) , Val ( 31 ) , and Ile ( 33 ) as crucial for protein S binding , with secondary effects from Leu ( 38 ) and Val ( 39 ) .", "entity": [{"entity": "protein S", "entity_type": "GENE", "pos": [85, 94]}], "task": "NER"}
{"text": "Synthesis of 22 - oxavitamin D3 analogues .", "entity": [], "task": "NER"}
{"text": "The plasmid was found to confer drug resistance specifically to LMB .", "entity": [], "task": "NER"}
{"text": "Our results suggest that at least some chloroplast - like tRNA genes in wheat mtDNA are transcribed , with transcripts undergoing processing , post - transcriptional modification and 3 ' - CCA addition , to produce mature tRNAs that may participate in mitochondrial protein synthesis .", "entity": [{"entity": "chloroplast - like tRNA genes", "entity_type": "GENE", "pos": [39, 68]}], "task": "NER"}
{"text": "Previously identified mutations in this variant have been within or close to the coding region of exon 1 of the HMBS gene , the only exon that is expressed solely in the ubiquitous isoform .", "entity": [{"entity": "HMBS gene", "entity_type": "GENE", "pos": [112, 121]}], "task": "NER"}
{"text": "Immunologic tolerance in rats during 13 weeks of inhalation exposure to trimellitic anhydride .", "entity": [], "task": "NER"}
{"text": "In stage I , histochemistry for copper was positive in 11 out of 21 cases : 6 cases were T + ; 1 case R + and 2 cases O + ; 2 cases were T + , R + , O + .", "entity": [], "task": "NER"}
{"text": "Rat cholesterol side - chain cleavage cytochrome P - 450 ( P - 450scc ) gene .", "entity": [{"entity": "Rat cholesterol side - chain cleavage cytochrome P - 450", "entity_type": "GENE", "pos": [0, 56]}, {"entity": "P - 450scc", "entity_type": "GENE", "pos": [59, 69]}], "task": "NER"}
{"text": "Almost every image that appears during a therapy session reveals a symbolic nature , but the very concept of symbol is not free from ambiguity some positions originated in different areas of investigation are mentioned , ending with a description of the traits that , according to the writer , bestow a symbolic character to images .", "entity": [], "task": "NER"}
{"text": "We have mapped the specific domains within each of the proteins responsible for this interaction .", "entity": [], "task": "NER"}
{"text": "A trend was observed toward increased graft half - life in era 2 ( p = NS ) .", "entity": [], "task": "NER"}
{"text": "After 15 min of hemorrhage the cardiovascular parameters were the same in fed and starved animals , but at 45 min striking differences were observed .", "entity": [], "task": "NER"}
{"text": "A 24 - year - old pregnant woman started to have hyperemesis gravidarum 6 weeks before admission .", "entity": [], "task": "NER"}
{"text": "The nucleoporin 98 gene ( NUP98 ) , which is rearranged in several acute myeloid leukemia translocations , is located within this region .", "entity": [{"entity": "nucleoporin 98 gene", "entity_type": "GENE", "pos": [4, 23]}, {"entity": "NUP98", "entity_type": "GENE", "pos": [26, 31]}], "task": "NER"}
{"text": "Human CD38 , a leukocyte receptor and ectoenzyme , is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide + - converting enzymes : extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and aplysian ADP - ribosyl cyclase .", "entity": [{"entity": "Human CD38", "entity_type": "GENE", "pos": [0, 10]}, {"entity": "nicotinamide adenine dinucleotide + - converting enzymes", "entity_type": "GENE", "pos": [100, 156]}, {"entity": "murine bone marrow stromal cell antigen 1", "entity_type": "GENE", "pos": [208, 249]}, {"entity": "aplysian ADP - ribosyl cyclase", "entity_type": "GENE", "pos": [254, 284]}], "task": "NER"}
{"text": "Juvenile angiofibromas .", "entity": [], "task": "NER"}
{"text": "Mutation of the HNF3 element significantly reduced promoter activity in HepG2 cells , whereas this element in isolation conferred HNF3beta responsiveness to a heterologous promoter .", "entity": [{"entity": "HNF3 element", "entity_type": "GENE", "pos": [16, 28]}, {"entity": "HNF3beta", "entity_type": "GENE", "pos": [130, 138]}], "task": "NER"}
{"text": "CONCLUSION : Detection of recurrent head and neck cancer is feasible with FDG PET .", "entity": [], "task": "NER"}
{"text": "The role of haptoglobin in asphyxia mechanism ( II ) - - Acute drowning and hanging", "entity": [{"entity": "haptoglobin", "entity_type": "GENE", "pos": [12, 23]}], "task": "NER"}
{"text": "Patients adopt new sets based partly on the original topic and partly on their own personal idiosyncratic concerns .", "entity": [], "task": "NER"}
{"text": "RESULTS : PET revealed wide variations in CBF between regions during isoflurane anaesthesia , particularly in comparison with propofol anaesthesia , while rCMRO2 decreased globally in a dose - dependent manner during both isoflurane and propofol anaesthesia .", "entity": [], "task": "NER"}
{"text": "Long chain acyl - CoA esters are important intermediates in degradation and synthesis of fatty acids , as well as having important functions in regulation of intermediary metabolism and gene expression .", "entity": [], "task": "NER"}
{"text": "The results of this study indicate that the Improved Crest Complete with longer rippled outer bristles provided significantly superior ( p < 0 . 05 ) interproximal penetration overall and at the gumline than the Colgate Total and Oral - B Advantage brushes .", "entity": [], "task": "NER"}
{"text": "Buchstein , L . - L .", "entity": [], "task": "NER"}
{"text": "The model of the complex provides a rationale for conserved ITAM residues , substrate specificity , and suggests that substrate binds only the active conformation of the Src family tyrosine kinase , unlike the ATP cofactor , which can bind the inactive form .", "entity": [{"entity": "ITAM", "entity_type": "GENE", "pos": [60, 64]}, {"entity": "Src family tyrosine kinase", "entity_type": "GENE", "pos": [170, 196]}], "task": "NER"}
{"text": "Sucrose - specific signalling represses translation of the Arabidopsis ATB2 bZIP transcription factor gene .", "entity": [{"entity": "Arabidopsis ATB2 bZIP transcription factor gene", "entity_type": "GENE", "pos": [59, 106]}], "task": "NER"}
{"text": "This is probably because , in vivo , some bacteria ( perhaps dormant forms ) are not entirely dependent upon urease for survival .", "entity": [{"entity": "urease", "entity_type": "GENE", "pos": [109, 115]}], "task": "NER"}
{"text": "Our aim was to evaluate this technique by cross - calibrating the DXA method with the carcass chemical analysis in a heterogeneous population of nondiabetic Wistar and diabetic GK rats ( 21 animals were used for precision error and reproducibility determinations and 26 were used for accuracy studies ) .", "entity": [], "task": "NER"}
{"text": "Biopsy of the lesion revealed granulomatous inflammation and numerous septate hyphae .", "entity": [], "task": "NER"}
{"text": "There was a highly significant decrease in serum eosinophil cationic protein in patients with elevated AGA .", "entity": [{"entity": "serum eosinophil cationic protein", "entity_type": "GENE", "pos": [43, 76]}, {"entity": "AGA", "entity_type": "GENE", "pos": [103, 106]}], "task": "NER"}
{"text": "The prototype now structures oncology - related information available on the Internet and also places resources maintained locally at users ' disposal .", "entity": [], "task": "NER"}
{"text": "Ischaemia and reperfusion injury in the kidney : current status and future direction .", "entity": [], "task": "NER"}
{"text": "No viral RNA replication could be detected in cells transfected with mutant RNAs .", "entity": [], "task": "NER"}
{"text": "As to the side effects of SISO , cylindruria with aggravation of microscopic hematuria and elevations of GOT , GPT and A1 - P were observed each one of them , respectively .", "entity": [{"entity": "GOT", "entity_type": "GENE", "pos": [105, 108]}, {"entity": "GPT", "entity_type": "GENE", "pos": [111, 114]}, {"entity": "A1 - P", "entity_type": "GENE", "pos": [119, 125]}], "task": "NER"}
{"text": "However , to date , no viable in vitro - generated deletion mutant of PSTVd has been reported .", "entity": [], "task": "NER"}
{"text": "Reduced cell numbers 72 h after insonation were recorded when the cells were insonated at an antinode but not when they were at a node .", "entity": [], "task": "NER"}
{"text": "We have now isolated cDNA for an invertebrate Pax - 6 protein from sea urchin embryos .", "entity": [{"entity": "invertebrate Pax - 6 protein from sea urchin embryos", "entity_type": "GENE", "pos": [33, 85]}], "task": "NER"}
{"text": "Mating response , ovulation rate , follicle and corpus luteum size , gestation length , pregnancy rate , lambing rate , and lamb birth weight were recorded .", "entity": [], "task": "NER"}
{"text": "From 1981 to 1989 , a total of 26 women with locally or regionally advanced carcinoma of the uterine cervix were treated with radiotherapy ( RT ) and pelvic regional hyperthermia ( HT ) , in the Divisions of Radiation Oncology at the University of Utah Medical Center ( UU ) and the Kenneth Norris Jr Cancer Hospital of the University of Southern California ( USC ) .", "entity": [], "task": "NER"}
{"text": "These proteins were detected by an antibody which recognizes the N - terminus of SRK3 and , in an F2 progeny segregating for the S3 haplotype , were only expressed in plants possessing the S3 haplotype .", "entity": [{"entity": "SRK3", "entity_type": "GENE", "pos": [81, 85]}, {"entity": "S3 haplotype", "entity_type": "GENE", "pos": [129, 141]}, {"entity": "S3 haplotype", "entity_type": "GENE", "pos": [189, 201]}], "task": "NER"}
{"text": "For all samples , the sensitivity of the blast flag on the CD3500 was 85 % with a specificity of 91 % ( STKS : sensitivity , 75 % ; specificity , 85 % ) ; the sensitivity of the CD3500 IG flag was 72 % with a specificity of 76 % ( STKS : sensitivity , 75 % : specificity , 73 % ) ; and the sensitivity of the NRBC flag was 43 % with a specificity of 94 % ( STKS sensitivity , 37 % ; specificity , 88 % ) .", "entity": [], "task": "NER"}
{"text": "Like other IAPs , ch - IAP1 contains the N - terminal baculovirus IAP repeats and C - terminal RING finger motifs .", "entity": [{"entity": "IAPs", "entity_type": "GENE", "pos": [11, 15]}, {"entity": "ch - IAP1", "entity_type": "GENE", "pos": [18, 27]}, {"entity": "N - terminal baculovirus IAP repeats", "entity_type": "GENE", "pos": [41, 77]}], "task": "NER"}
{"text": "As in the case of the chicken homologue , there are two hPR forms , A and B , which originate from translational initiation at AUG2 ( codon 165 ) and AUG1 , respectively .", "entity": [{"entity": "hPR", "entity_type": "GENE", "pos": [56, 59]}], "task": "NER"}
{"text": "A biopsy specimen taken from the frontal branch of the right superficial artery revealed segmental intimal thickening consistent with intimal fibroplasia type FMD upon histological examination .", "entity": [], "task": "NER"}
{"text": "Serum alkaline phosphatase and creatine kinase activities were significantly increased in the A praelongus - fed pigs and significantly decreased in Na2SeO4 - fed pigs .", "entity": [{"entity": "Serum alkaline phosphatase", "entity_type": "GENE", "pos": [0, 26]}, {"entity": "creatine kinase", "entity_type": "GENE", "pos": [31, 46]}], "task": "NER"}
{"text": "The activity of gamma - glutamyl transpeptidase in the serum of problem drinkers .", "entity": [{"entity": "gamma - glutamyl transpeptidase", "entity_type": "GENE", "pos": [16, 47]}], "task": "NER"}
{"text": "The content of monoamine metabolites , 5 - hydroxyindoleacetic acid , 5 - HIAA , and homovanillic acid ( HVA ) , and - - for 17 patients - - tryptophan , in the cerebrospinal fluid was determined .", "entity": [], "task": "NER"}
{"text": "Reduced risk of upper gastrointestinal ulcer complications with celecoxib , a novel COX - 2 inhibitor .", "entity": [{"entity": "COX - 2", "entity_type": "GENE", "pos": [84, 91]}], "task": "NER"}
{"text": "Mutations in Saccharomyces cerevisiae that block meiotic prophase chromosome metabolism and confer cell cycle arrest at pachytene identify two new meiosis - specific genes SAE1 and SAE3 .", "entity": [{"entity": "meiosis - specific genes SAE1", "entity_type": "GENE", "pos": [147, 176]}, {"entity": "SAE3", "entity_type": "GENE", "pos": [181, 185]}], "task": "NER"}
{"text": "The transfer by conjugation to E . coli K12 of ampicillin and carbenicillin resistance was obtained with 14 strains : ( E . coli : 9 , C . freundii : 1 , K . pneumoniae : 1 , E . cloacae : 2 , P . stuartii : 1 ) .", "entity": [], "task": "NER"}
{"text": "Over 9 kb of DNA sequence was obtained for one clone ( A1 ) with a total IGS length of approximately 12 . 4 kb .", "entity": [], "task": "NER"}
{"text": "Following EGF or NGF stimulation of the v - CrkPC12 cells , the v - Crk protein itself became tyrosine phosphorylated within 1 min .", "entity": [{"entity": "EGF", "entity_type": "GENE", "pos": [10, 13]}, {"entity": "NGF", "entity_type": "GENE", "pos": [17, 20]}, {"entity": "v - Crk", "entity_type": "GENE", "pos": [40, 47]}], "task": "NER"}
{"text": "After nine months GFR improved spontaneously to 32 ml / min / 1 . 73 m2 despite no improvement in his hypertension .", "entity": [], "task": "NER"}
{"text": "Insulin - stimulated autophosphorylation at specific sites in the tyrosine kinase domain of the receptor ' s beta - subunit is correlated kinetically with activation of kinase - catalyzed phosphorylation of a model substrate ( reduced and carboxyamidomethylated lysozyme ; RCAM - lysozyme ) .", "entity": [{"entity": "Insulin", "entity_type": "GENE", "pos": [0, 7]}, {"entity": "tyrosine kinase domain", "entity_type": "GENE", "pos": [66, 88]}, {"entity": "lysozyme", "entity_type": "GENE", "pos": [262, 270]}, {"entity": "RCAM - lysozyme", "entity_type": "GENE", "pos": [273, 288]}], "task": "NER"}
{"text": "Likewise , the consensus signal believed to be involved in terminating VV early gene transcription , TTTTTNT , was evident at the 3 ' - boundary of both the N2 and M1 ORFs suggesting that these genes may be VV early genes .", "entity": [{"entity": "VV early gene", "entity_type": "GENE", "pos": [71, 84]}, {"entity": "VV early genes", "entity_type": "GENE", "pos": [207, 221]}], "task": "NER"}
{"text": "Enzymatic and chemical structure probing revealed mainly the conserved terminal part ( termed 3 ' C ) of the DI9c 3 ' UTR containing distinctive RNA motifs , i . e . , a stable stem - loop , SL I , near the RNA 3 ' terminus and a considerably less stable stem - loop , SL II , that forms the 5 ' portion of 3 ' C .", "entity": [], "task": "NER"}
{"text": "Attention is devoted in particular to the action of thermoregulating nervous and hormonal mechanisms .", "entity": [], "task": "NER"}
{"text": "ES cells in which the gene for the erythroid transcription factor GATA - 1 has been disrupted fail to produce mature erythroid cells either in vivo or in vitro .", "entity": [{"entity": "GATA - 1", "entity_type": "GENE", "pos": [66, 74]}], "task": "NER"}
{"text": "Acidic carboxyl - terminal domain of gene 2 . 5 protein of bacteriophage T7 is essential for protein - protein interactions .", "entity": [{"entity": "gene 2 . 5 protein of bacteriophage T7", "entity_type": "GENE", "pos": [37, 75]}], "task": "NER"}
{"text": "They encode proteins whose core regions display great similarity to Aspergillus HAPB , HAPC and HAPE and to known HAP homologs from other organisms .", "entity": [{"entity": "Aspergillus HAPB", "entity_type": "GENE", "pos": [68, 84]}, {"entity": "HAPC", "entity_type": "GENE", "pos": [87, 91]}, {"entity": "HAPE", "entity_type": "GENE", "pos": [96, 100]}, {"entity": "HAP homologs", "entity_type": "GENE", "pos": [114, 126]}], "task": "NER"}
{"text": "Three of these positions are novel in that they had not been identified to be important for binding PC by previous crystallographic analysis .", "entity": [], "task": "NER"}
{"text": "Three transcriptional control elements within 300 base pairs of the 5 ' - flanking region of the rat glucagon gene interact with regulatory cellular proteins and direct transcription only in glucagon - producing islet cells .", "entity": [{"entity": "rat glucagon gene", "entity_type": "GENE", "pos": [97, 114]}, {"entity": "glucagon", "entity_type": "GENE", "pos": [191, 199]}], "task": "NER"}
{"text": "Fusion proteins were isolated by affinity chromatography on APTG - Sepharose .", "entity": [], "task": "NER"}
{"text": "( 99m ) Tc Ethyl Cysteinate Dimer stable during 6h has contributed to develop ictal studies to evaluate the location of partial seizure .", "entity": [], "task": "NER"}
{"text": "The results of a study to investigate the effectiveness of a propolis - containing mouthrinse in the inhibition of de novo plaque formation are presented .", "entity": [], "task": "NER"}
{"text": "We suggest that this effect of Myc is mediated by its action upstream of cyclin E - CDK2 , and occurs via the neutralization of p27 ( Kip1 ) family proteins , rather than induction of Cdc25A .", "entity": [{"entity": "Myc", "entity_type": "GENE", "pos": [31, 34]}, {"entity": "cyclin E", "entity_type": "GENE", "pos": [73, 81]}, {"entity": "CDK2", "entity_type": "GENE", "pos": [84, 88]}, {"entity": "p27", "entity_type": "GENE", "pos": [128, 131]}, {"entity": "Kip1", "entity_type": "GENE", "pos": [134, 138]}, {"entity": "Cdc25A", "entity_type": "GENE", "pos": [184, 190]}], "task": "NER"}
{"text": "A less common and much more perplexing circumstance occurs when evaluating patients with sarcoidosis established for several years present with evidence of progressive or chronic pulmonary involvement and dyspnea .", "entity": [], "task": "NER"}
{"text": "The training programs had a duration of 30 days , 5 days / week , and was performed on a motor - driven treadmill .", "entity": [], "task": "NER"}
{"text": "( 1992 ) J .", "entity": [], "task": "NER"}
{"text": "The avian carcinoma virus MH2 contains a hybrid gene delta gag - mht with a contiguous open reading frame of 2682 base pairs as well as v - myc and avian helper virus - related sequences . delta gag is a partial retroviral core protein gene while v - mht and v - myc are cell - drived sequences .", "entity": [{"entity": "delta gag", "entity_type": "GENE", "pos": [53, 62]}, {"entity": "mht", "entity_type": "GENE", "pos": [65, 68]}, {"entity": "v - myc", "entity_type": "GENE", "pos": [136, 143]}, {"entity": "delta gag", "entity_type": "GENE", "pos": [189, 198]}, {"entity": "retroviral core protein gene", "entity_type": "GENE", "pos": [212, 240]}, {"entity": "v - mht", "entity_type": "GENE", "pos": [247, 254]}, {"entity": "v - myc", "entity_type": "GENE", "pos": [259, 266]}], "task": "NER"}
{"text": "The DW directions uniformly sampled the diffusion ellipsoid surface .", "entity": [], "task": "NER"}
{"text": "The recent concept of a bioartificial organ is an attempt to avoid such disadvantages .", "entity": [], "task": "NER"}
{"text": "The pressure measurements under steady flow conditions showed that the hemodynamic performance ( including pressure gradient and effective orifice area ) of SPAB is superior to that of its stented counterpart , especially in the smaller sizes .", "entity": [], "task": "NER"}
{"text": "Recent , highly visible reviews on the subject have clearly pointed out that little is known about the cellular mechanisms through which inhaled asbestos fibers cause the well known , debilitating lung disease - asbestosis ( i . e . interstitial pulmonary fibrosis ) .", "entity": [], "task": "NER"}
{"text": "During chronic treatment with salmon calcitonin , alkaline phosphatase activity and urinary hydroxyproline excretion decrease on an average of 50 % in patients with Paget ' s disease .", "entity": [{"entity": "salmon calcitonin", "entity_type": "GENE", "pos": [30, 47]}, {"entity": "alkaline phosphatase", "entity_type": "GENE", "pos": [50, 70]}], "task": "NER"}
{"text": "Cerebral blood flow was measured using the iv method of 133 - Xe CBF determination and AVDO2 was measured using systemic arterial - jugular venous oxygen content differences .", "entity": [], "task": "NER"}
{"text": "Expression of FNCAT increased on serum treatment indicating that the region of the FN gene between positions + 69 and - 510 bp mediated serum responsiveness .", "entity": [{"entity": "FNCAT", "entity_type": "GENE", "pos": [14, 19]}, {"entity": "FN gene", "entity_type": "GENE", "pos": [83, 90]}], "task": "NER"}
{"text": "Gallstone - formation has traditionally been attributed to supersaturation of bile with cholesterol .", "entity": [], "task": "NER"}
{"text": "Possible consequences of such binder distribution through powder aggregates are discussed .", "entity": [], "task": "NER"}
{"text": "Bile salts , hormonal control , and the male disadvantage .", "entity": [], "task": "NER"}
{"text": "The fusion gene cassette was placed under the control of a vaccinia virus early promoter and cloned in a host - restricted fowlpox viral vector .", "entity": [{"entity": "vaccinia virus early promoter", "entity_type": "GENE", "pos": [59, 88]}], "task": "NER"}
{"text": "We describe a novel stat - related factor , p93 , that is found in EGF - treated A431 cell extracts but appears to be absent in bovine fibroblast growth factor ( bFGF ) , IFN - gamma , tumor necrosis factor - alpha ( TNF - alpha ) , and untreated cells . p93 appears to be antigenically related to stat91 . p185c - neu + , EGFr + ( M1 ) , and p185c - neu - kinase inactive , EGFr + ( NEN757 ) expressing cells undergo different mitotic responses to EGF .", "entity": [{"entity": "stat - related factor", "entity_type": "GENE", "pos": [20, 41]}, {"entity": "p93", "entity_type": "GENE", "pos": [44, 47]}, {"entity": "EGF", "entity_type": "GENE", "pos": [67, 70]}, {"entity": "bovine fibroblast growth factor", "entity_type": "GENE", "pos": [128, 159]}, {"entity": "bFGF", "entity_type": "GENE", "pos": [162, 166]}, {"entity": "IFN - gamma", "entity_type": "GENE", "pos": [171, 182]}, {"entity": "tumor necrosis factor - alpha", "entity_type": "GENE", "pos": [185, 214]}, {"entity": "TNF - alpha", "entity_type": "GENE", "pos": [217, 228]}, {"entity": "p93", "entity_type": "GENE", "pos": [255, 258]}, {"entity": "stat91", "entity_type": "GENE", "pos": [298, 304]}, {"entity": "p185c", "entity_type": "GENE", "pos": [307, 312]}, {"entity": "neu", "entity_type": "GENE", "pos": [315, 318]}, {"entity": "EGFr +", "entity_type": "GENE", "pos": [323, 329]}, {"entity": "M1", "entity_type": "GENE", "pos": [332, 334]}, {"entity": "p185c", "entity_type": "GENE", "pos": [343, 348]}, {"entity": "neu", "entity_type": "GENE", "pos": [351, 354]}, {"entity": "EGFr +", "entity_type": "GENE", "pos": [375, 381]}, {"entity": "NEN757", "entity_type": "GENE", "pos": [384, 390]}, {"entity": "EGF", "entity_type": "GENE", "pos": [449, 452]}], "task": "NER"}
{"text": "MRI measurements of the brain .", "entity": [], "task": "NER"}
{"text": "Phosphorylation by Cdc28 activates the Cdc20 - dependent activity of the anaphase - promoting complex .", "entity": [{"entity": "Cdc28", "entity_type": "GENE", "pos": [19, 24]}, {"entity": "Cdc20", "entity_type": "GENE", "pos": [39, 44]}], "task": "NER"}
{"text": "Phosphorylated tyrosine residues were subsequently identified by sequencing the separated phosphopeptides by matrix assisted laser desorption ionization mass spectrometry ( MALDI - MS ) and Edman degradation .", "entity": [], "task": "NER"}
{"text": "Superovulation with intrauterine insemination ( SO - IUI ) has been suggested as an alternative to gamete intrafallopian transfer ( GIFT ) , despite the absence of controlled or comparative trials .", "entity": [], "task": "NER"}
{"text": "One of these elements resembles the binding site of a previously identified cellular \" transcription \" factor .", "entity": [], "task": "NER"}
{"text": "The Rep78 protein of adeno - associated virus ( AAV ) contains amino acid sequence motifs common to rolling - circle replication ( RCR ) initiator proteins .", "entity": [{"entity": "Rep78 protein", "entity_type": "GENE", "pos": [4, 17]}, {"entity": "rolling - circle replication ( RCR ) initiator proteins", "entity_type": "GENE", "pos": [100, 155]}], "task": "NER"}
{"text": "METHODS : CD4 cell counts and interview data were recorded in a survey of 136 adult patients attending a community hospital - based HIV outpatient clinic .", "entity": [{"entity": "CD4", "entity_type": "GENE", "pos": [10, 13]}], "task": "NER"}
{"text": "Based on 29 determinations of the glucose from sinigrin , analyzed under different conditions , accuracy of the total glucosinolate determination was 94 . 8 + / - 7 . 3 % .", "entity": [], "task": "NER"}
{"text": "Transcriptional analysis of this gene cluster was performed by detecting the presence of mRNAs spanning adjacent genes as well as by using a promoterless lacZ reporter gene fused to each of the seven genes contained in the tol - oprL locus .", "entity": [{"entity": "lacZ reporter gene", "entity_type": "GENE", "pos": [154, 172]}, {"entity": "tol", "entity_type": "GENE", "pos": [223, 226]}, {"entity": "oprL", "entity_type": "GENE", "pos": [229, 233]}], "task": "NER"}
{"text": "The regions encoding the mature proteinases were cloned into an expression vector and recombinant protein produced in Escherichia coli .", "entity": [], "task": "NER"}
{"text": "H .", "entity": [], "task": "NER"}
{"text": "Rhinovirus 2A protease and foot - and - mouth - disease virus L protease were used to analyze the association of eIF4G with eIF4A , eIF4E , and eIF3 .", "entity": [{"entity": "Rhinovirus 2A protease", "entity_type": "GENE", "pos": [0, 22]}, {"entity": "foot - and - mouth - disease virus L protease", "entity_type": "GENE", "pos": [27, 72]}, {"entity": "eIF4G", "entity_type": "GENE", "pos": [113, 118]}, {"entity": "eIF4A", "entity_type": "GENE", "pos": [124, 129]}, {"entity": "eIF4E", "entity_type": "GENE", "pos": [132, 137]}, {"entity": "eIF3", "entity_type": "GENE", "pos": [144, 148]}], "task": "NER"}
{"text": "METHODS : Two patients developed cervical myelopathy or radiculopathy after spinal manipulation therapy , and magnetic resonance imaging showed herniated cervical discs at C4 - C5 and C6 - C7 , respectively .", "entity": [], "task": "NER"}
{"text": "This increased frequency of infection has been accompanied by significant excess mortality .", "entity": [], "task": "NER"}
{"text": "One of the repeating domains ( Yheb1 ) , consisting of 67 amino acids , was cloned from the E . coli chromosome and purified by metal chelating chromatography .", "entity": [{"entity": "Yheb1", "entity_type": "GENE", "pos": [31, 36]}], "task": "NER"}
{"text": "Assessment of two anion - exchange resins for direct use in the screening method for urinary porphobilinogen .", "entity": [], "task": "NER"}
{"text": "These studies define a class of DNA elements with a mode of action that has not been heretofore described .", "entity": [], "task": "NER"}
{"text": "Using lacZ - inducible T cells as a probe , we screened a splenic cDNA library in transiently transfected antigen - presenting cells ( APCs ) and isolated a cDNA clone that allowed expression of the appropriate peptide / Kb MHC complex in APC .", "entity": [{"entity": "lacZ", "entity_type": "GENE", "pos": [6, 10]}, {"entity": "peptide / Kb MHC complex", "entity_type": "GENE", "pos": [211, 235]}], "task": "NER"}
{"text": "This results in a decreased secretion of immunoglobulin A , and , consequently , a decreased resistance against infections .", "entity": [{"entity": "immunoglobulin A", "entity_type": "GENE", "pos": [41, 57]}], "task": "NER"}
{"text": "A previously developed kinetic model was used to identify major chemical reaction pathways involving PAH in the afterburner .", "entity": [], "task": "NER"}
{"text": "Regulation of the p21 - activated kinase ( PAK ) by a human Gbeta - like WD - repeat protein , hPIP1 .", "entity": [{"entity": "p21 - activated kinase", "entity_type": "GENE", "pos": [18, 40]}, {"entity": "PAK", "entity_type": "GENE", "pos": [43, 46]}, {"entity": "human Gbeta - like", "entity_type": "GENE", "pos": [54, 72]}, {"entity": "hPIP1", "entity_type": "GENE", "pos": [95, 100]}], "task": "NER"}
{"text": "Activation of HIV - 1 requires the binding of host cell transcription factors to cis elements in the proviral long terminal repeat ( LTR ) .", "entity": [], "task": "NER"}
{"text": "Based on the ratios of the areas under the concentration - time curves in CSF and serum , the overall penetration of rifampicin into CSF was 0 . 13 - 0 . 42 ( median = 0 . 22 ) .", "entity": [], "task": "NER"}
{"text": "Adaptability of Nippostrongylus brasiliensis ( Travassos , 1914 ) to lead contamination", "entity": [], "task": "NER"}
{"text": "In early midgestation embryos it is expressed in telencephalic , diencephalic and mesencephalic regions but from day 11 . 75 of gestation its expression disappears from dorsal telencephalon and is confined to diencephalic and mesencephalic regions .", "entity": [], "task": "NER"}
{"text": "A child presumed to have the 21 - hydroxylase deficiency form of congenital adrenal hyperplasia was studied extensively as an infant .", "entity": [{"entity": "21 - hydroxylase", "entity_type": "GENE", "pos": [29, 45]}], "task": "NER"}
{"text": "The size and the predicted N - terminal sequence of the mouse protein were confirmed experimentally .", "entity": [], "task": "NER"}
{"text": "It was found that Nopp140 binds primarily to the CK2 regulatory subunit , beta .", "entity": [{"entity": "Nopp140", "entity_type": "GENE", "pos": [18, 25]}, {"entity": "CK2 regulatory subunit , beta", "entity_type": "GENE", "pos": [49, 78]}], "task": "NER"}
{"text": "Further , more recent communications suggest that liver disease led to a differential alteration of the cytochrome P - 450s with regard to protein content and activity .", "entity": [{"entity": "cytochrome P - 450s", "entity_type": "GENE", "pos": [104, 123]}], "task": "NER"}
{"text": "A constructed phylogenetic tree suggests that the UbcP1 protein may represent a member of a distinct subfamily of E2s .", "entity": [{"entity": "UbcP1 protein", "entity_type": "GENE", "pos": [50, 63]}, {"entity": "E2s", "entity_type": "GENE", "pos": [114, 117]}], "task": "NER"}
{"text": "Isolates of B . burgdorferi from humans , rodents , and I . dammini are usually indistinguishable , but strains of B . burgdorferi with different major proteins have been identified .", "entity": [], "task": "NER"}
{"text": "Alignment of the rat and human WIN cDNAs and their comparison with mouse genomic sequence revealed that the WIN DNA binding domain is encoded by four exons , two of which ( exons 4 and 6 ) are alternatively spliced to generate at least three classes of mRNA transcripts .", "entity": [{"entity": "rat and human WIN cDNAs", "entity_type": "GENE", "pos": [17, 40]}, {"entity": "WIN DNA binding domain", "entity_type": "GENE", "pos": [108, 130]}], "task": "NER"}
{"text": "25 patients received 20 mgs of hyoscine N - butyl bromide and the rest 5 mgs propinoxate , i . v . plus diazepam .", "entity": [], "task": "NER"}
{"text": "The activity of plasminogen activator has been measured in tissue sections with the aid of a modified Todd technique .", "entity": [{"entity": "plasminogen activator", "entity_type": "GENE", "pos": [16, 37]}], "task": "NER"}
{"text": "These sequences were further tested for the presence of an enhancer element , by their ability to activate a fusion reporter gene consisting of the CAT gene linked to the gamma - globin gene promoter , in erythroid ( K562 ) and non - erythroid ( HeLa ) cells .", "entity": [{"entity": "CAT gene", "entity_type": "GENE", "pos": [148, 156]}, {"entity": "gamma - globin gene promoter", "entity_type": "GENE", "pos": [171, 199]}], "task": "NER"}
{"text": "Here we demonstrate that CD40 or IgM receptor stimulation of primary B cells results in transactivation of this enhancer .", "entity": [{"entity": "CD40", "entity_type": "GENE", "pos": [25, 29]}, {"entity": "IgM receptor", "entity_type": "GENE", "pos": [33, 45]}], "task": "NER"}
{"text": "DESIGN , SETTING AND SUBJECTS : The analysis is based on data collected in the first two rounds of the nationally representative Ghana Living Standards Survey , held in 1987 / 88 ( GLSS - I ) and 1988 / 89 ( GLSS - II ) , with both surveys covering approximately 3000 households .", "entity": [], "task": "NER"}
{"text": "Genetic and physiological experiments suggest a close relationship between cdc27 + and the cdc2 + gene , a key regulator of mitosis in yeast and also in higher eukaryotic cells .", "entity": [{"entity": "cdc27 +", "entity_type": "GENE", "pos": [75, 82]}, {"entity": "cdc2 + gene", "entity_type": "GENE", "pos": [91, 102]}], "task": "NER"}
{"text": "Association of Syk protein tyrosine kinase ( PTK ) with LMP2A occurs at the two tyrosines of the LMP2A immunoreceptor tyrosine - based activation motif , and it is hypothesized that Lyn PTK associates with the YEEA amino acid motif at LMP2A tyrosine 112 ( Y112 ) .", "entity": [{"entity": "Syk", "entity_type": "GENE", "pos": [15, 18]}, {"entity": "protein tyrosine kinase", "entity_type": "GENE", "pos": [19, 42]}, {"entity": "PTK", "entity_type": "GENE", "pos": [45, 48]}, {"entity": "LMP2A", "entity_type": "GENE", "pos": [56, 61]}, {"entity": "LMP2A immunoreceptor", "entity_type": "GENE", "pos": [97, 117]}, {"entity": "Lyn", "entity_type": "GENE", "pos": [182, 185]}, {"entity": "PTK", "entity_type": "GENE", "pos": [186, 189]}, {"entity": "LMP2A", "entity_type": "GENE", "pos": [235, 240]}], "task": "NER"}
{"text": "Theoretical mechanisms of hyperuricemia .", "entity": [], "task": "NER"}
{"text": "As a result , relative biological effects ( RBE ) of 2 . 3 - 2 . 7 was obtained from the straight line that was given by modifying by the method of least squares the curves of the frequency of anomalous fetuses in total implants and survived embryos irradiated from 20 to 120 rad by Cf - 252 and from 80 to 220 rad by Co - 60 on day 8 of pregnancy .", "entity": [], "task": "NER"}
{"text": "Moclobemide is a well - tolerated alternative antidepressant , but there is a need for prospective controlled trials to evaluate its long - term efficacy .", "entity": [], "task": "NER"}
{"text": "In a pilot study in which two dogs were given parenteral rifampin before and after operation and grafts were preclotted with blood that contained rifampin , it was suggested that there was a slight increase in inhibition at 24 hours ( 93 % ) .", "entity": [], "task": "NER"}
{"text": "Northern blot analyses were used to examine the regulated expression of the cys - 14 + gene .", "entity": [{"entity": "cys - 14 + gene", "entity_type": "GENE", "pos": [76, 91]}], "task": "NER"}
{"text": "The mouse tapasin gene was mapped about 70 kilobases from H2 - K at the centromeric end of the mouse MHC .", "entity": [{"entity": "mouse tapasin gene", "entity_type": "GENE", "pos": [4, 22]}, {"entity": "H2 - K", "entity_type": "GENE", "pos": [58, 64]}, {"entity": "mouse MHC", "entity_type": "GENE", "pos": [95, 104]}], "task": "NER"}
{"text": "Conversion of glucose phosphate - 14C to glucose - 14C in passage through human brain in vivo .", "entity": [], "task": "NER"}
{"text": "New , selective catechol - O - methyltransferase inhibitors as therapeutic agents in Parkinson ' s disease .", "entity": [{"entity": "catechol - O - methyltransferase", "entity_type": "GENE", "pos": [16, 48]}], "task": "NER"}
{"text": "The sequence of the gene upstream to the cap site contains characteristic RNA polymerase II promoter - binding sites : a putative TATA box at position - 29 and a Sp 1 binding site ( GGGGCGGAGA ) at position - 48 .", "entity": [{"entity": "RNA polymerase II promoter - binding sites", "entity_type": "GENE", "pos": [74, 116]}, {"entity": "Sp 1 binding site", "entity_type": "GENE", "pos": [162, 179]}], "task": "NER"}
{"text": "We propose that , while Y . lipolytica CEN DNA is essential for plasmid maintenance , this function can be supplied by several sub - fragments which , together , form the active chromosomal centromere .", "entity": [], "task": "NER"}
{"text": "These three groups were further examined with regard to the modulation of discharge rate i ) during motor activity in W , ii ) at the transitional phase from SS to paradoxical sleep ( PS ) , iii ) during rapid eye movements ( REMs ) in PS , and iv ) following electrical stimulation of the midbrain reticular formation ( MRF ) .", "entity": [], "task": "NER"}
{"text": "Benzyl alcohol administration in neonates .", "entity": [], "task": "NER"}
{"text": "Id - 1H and Id - 2H seem to be human homologues of mouse Id - 1 and Id - 2 , respectively , and have potential to encode 154 and 135 amino acid proteins .", "entity": [{"entity": "Id - 1H", "entity_type": "GENE", "pos": [0, 7]}, {"entity": "Id - 2H", "entity_type": "GENE", "pos": [12, 19]}, {"entity": "mouse Id - 1", "entity_type": "GENE", "pos": [51, 63]}, {"entity": "Id - 2", "entity_type": "GENE", "pos": [68, 74]}], "task": "NER"}
{"text": "Normal dogs were exposed to either 10 , 15 , or 30 Gy of X rays to a single hemisphere and the gross and histopathologic changes were evaluated qualitatively .", "entity": [], "task": "NER"}
{"text": "The characterization of fly receptors with features similar to mammalian glycoprotein hormone receptors allows a better understanding of the evolution of this unique group of GPCRs and future elucidation of their ligand signaling mechanisms .", "entity": [{"entity": "mammalian glycoprotein hormone receptors", "entity_type": "GENE", "pos": [63, 103]}, {"entity": "GPCRs", "entity_type": "GENE", "pos": [175, 180]}], "task": "NER"}
{"text": "To study the mechanisms and the signaling pathways involved , IGF - 1R promoter reporter constructs were transiently transfected in CHO - AT1 cells that overexpress angiotensin AT1 receptors .", "entity": [{"entity": "IGF - 1R promoter reporter constructs", "entity_type": "GENE", "pos": [62, 99]}, {"entity": "angiotensin AT1 receptors", "entity_type": "GENE", "pos": [165, 190]}], "task": "NER"}
{"text": "Importin beta mediates nuclear translocation of Smad 3 .", "entity": [{"entity": "Importin beta", "entity_type": "GENE", "pos": [0, 13]}, {"entity": "Smad 3", "entity_type": "GENE", "pos": [48, 54]}], "task": "NER"}
{"text": "In summary , the only treatment - related effect noted in this study was hydrocarbon nephropathy in male rats , which is not considered relevant for human health .", "entity": [], "task": "NER"}
{"text": "Characterization of an unusual tRNA - like sequence found inserted in a Neurospora retroplasmid .", "entity": [], "task": "NER"}
{"text": "Gel shift analysis of protein binding from nuclear extracts to these caveolin promoter DNA sequences , together with DNase I footprinting , confirmed nucleoprotein binding to the SRE - like elements as part of the transcriptional response to LDL - FC .", "entity": [{"entity": "caveolin promoter DNA sequences", "entity_type": "GENE", "pos": [69, 100]}, {"entity": "DNase I", "entity_type": "GENE", "pos": [117, 124]}, {"entity": "LDL - FC", "entity_type": "GENE", "pos": [242, 250]}], "task": "NER"}
{"text": "The Ca2 + concentration in rats serum after intragastrically fenarimol administration ( doses 1 / 40 , 1 / 20 and 1 / 10 LD50 ) during 5 days was investigated .", "entity": [], "task": "NER"}
{"text": "Furthermore , deletion of two potential Ste11 recognition sites in the fus1 promoter region abolished transcription , and expression could be restored when we inserted a different Ste11 site from the mat1 - P promoter .", "entity": [{"entity": "Ste11 recognition sites", "entity_type": "GENE", "pos": [40, 63]}, {"entity": "fus1 promoter", "entity_type": "GENE", "pos": [71, 84]}, {"entity": "Ste11 site", "entity_type": "GENE", "pos": [180, 190]}, {"entity": "mat1 - P promoter", "entity_type": "GENE", "pos": [200, 217]}], "task": "NER"}
{"text": "J . , & Olefsky , J .", "entity": [], "task": "NER"}
{"text": "Early attempts for modifying growth functions to annual variations dating back up to 2 decades are recalled together with examples for their application showing rather different degrees of approximation .", "entity": [], "task": "NER"}
{"text": "PRIP contains two LXXLL signature motifs .", "entity": [{"entity": "PRIP", "entity_type": "GENE", "pos": [0, 4]}], "task": "NER"}
{"text": "BPN can be experimentally produced by intratracheal inoculation of microorganisms in high concentrations and ventilator - associated BPN by ventilating baboons with oleic - acid lung injury .", "entity": [], "task": "NER"}
{"text": "Coexpression of a dominant negative c - jun antagonized the ras - dependent stimulation of the 92 - kDa gelatinase B promoter - driven CAT reporter .", "entity": [{"entity": "dominant negative c - jun", "entity_type": "GENE", "pos": [18, 43]}, {"entity": "ras", "entity_type": "GENE", "pos": [60, 63]}, {"entity": "92 - kDa gelatinase B", "entity_type": "GENE", "pos": [95, 116]}, {"entity": "CAT reporter", "entity_type": "GENE", "pos": [135, 147]}], "task": "NER"}
{"text": "However , the safety of design 4 was assured as long as all patients received three courses of chemotherapy , which is unusual in phase I studies in Japan .", "entity": [], "task": "NER"}
{"text": "The plants were then brought to our Houston laboratory where they were measured and analyzed for lignin and protein content and for phenylalanine ammonia - lyase ( PAL ) and peroxidase activities .", "entity": [{"entity": "phenylalanine ammonia - lyase", "entity_type": "GENE", "pos": [132, 161]}, {"entity": "PAL", "entity_type": "GENE", "pos": [164, 167]}, {"entity": "peroxidase", "entity_type": "GENE", "pos": [174, 184]}], "task": "NER"}
{"text": "The nucleotide sequence of a PCR - amplified SMT3A genomic DNA fragment was found to be identical to that of SMT3A cDNA , indicating the absence of intron ( s ) in its protein coding region .", "entity": [{"entity": "SMT3A", "entity_type": "GENE", "pos": [45, 50]}, {"entity": "SMT3A cDNA", "entity_type": "GENE", "pos": [109, 119]}], "task": "NER"}
{"text": "Activation of tyrosine kinase - containing receptors , heterotrimeric G proteins , and protein kinase C enhanced the activities of both MEK isoforms in 293 and PC12 cells .", "entity": [{"entity": "tyrosine kinase - containing receptors", "entity_type": "GENE", "pos": [14, 52]}, {"entity": "heterotrimeric G proteins", "entity_type": "GENE", "pos": [55, 80]}, {"entity": "protein kinase C", "entity_type": "GENE", "pos": [87, 103]}, {"entity": "MEK isoforms", "entity_type": "GENE", "pos": [136, 148]}], "task": "NER"}
{"text": "CONCLUSIONS : Transpulmonary stable air microbubbles bound to a galactose carrier represent a useful and safe contrast agent in case of an insufficient native signal in transcranial Doppler investigation .", "entity": [], "task": "NER"}
{"text": "DP - 1 and DP - 2 encode maternally stored transcripts that are expressed during early development .", "entity": [{"entity": "DP - 1", "entity_type": "GENE", "pos": [0, 6]}, {"entity": "DP - 2", "entity_type": "GENE", "pos": [11, 17]}], "task": "NER"}
{"text": "Human recombinant erythropoietin ( r - HuEPO , EprexR ) was administered to 8 children with chronic renal failure and high transfusion requirement .", "entity": [{"entity": "Human recombinant erythropoietin", "entity_type": "GENE", "pos": [0, 32]}, {"entity": "r - HuEPO", "entity_type": "GENE", "pos": [35, 44]}, {"entity": "EprexR", "entity_type": "GENE", "pos": [47, 53]}], "task": "NER"}
{"text": "Specifically , we engineered two chimeras in which the N - terminal lobe of the SH1 domain of c - Abl was swapped with that of v - Src .", "entity": [{"entity": "SH1 domain", "entity_type": "GENE", "pos": [80, 90]}, {"entity": "c - Abl", "entity_type": "GENE", "pos": [94, 101]}, {"entity": "v - Src", "entity_type": "GENE", "pos": [127, 134]}], "task": "NER"}
{"text": "Indications for therapy using MAO inhibitors", "entity": [{"entity": "MAO", "entity_type": "GENE", "pos": [30, 33]}], "task": "NER"}
{"text": "Although IL - 6 can activate ERK - 1 in HepG2 cells , STAT3 transactivation and Ser ( 727 ) phosphorylation were not reduced by using the MAP kinase / ERK kinase ( MEK ) inhibitor PD98059 or by overexpression of dominant - negative Raf .", "entity": [{"entity": "IL - 6", "entity_type": "GENE", "pos": [9, 15]}, {"entity": "ERK - 1", "entity_type": "GENE", "pos": [29, 36]}, {"entity": "STAT3", "entity_type": "GENE", "pos": [54, 59]}, {"entity": "MAP kinase", "entity_type": "GENE", "pos": [138, 148]}, {"entity": "ERK kinase", "entity_type": "GENE", "pos": [151, 161]}, {"entity": "MEK", "entity_type": "GENE", "pos": [164, 167]}, {"entity": "Raf", "entity_type": "GENE", "pos": [232, 235]}], "task": "NER"}
{"text": "Mean disposition constants ( + / - SD ) were obtained from individualized fits ( V1 : 0 . 398 + / - 0 . 336 LITER / KG , Vdarea : 2 . 53 + / - 0 . 72 liter / kg , alpha : 0 . 316 + / - 0 . 294 min - 1 , beta : 0 . 00204 + / - 0 . 00262 min - 1 , k2 : 0 . 0305 + / - 0 . 0101 min - 1 ) .", "entity": [], "task": "NER"}
{"text": "Clinical trials bring informations for pharmacology and epidemiology .", "entity": [], "task": "NER"}
{"text": "We have compared the ability of GST - Bem3 to serve as a GAP for Cdc42Hs relative to other members of the rho - GAP subfamily and found the following order of potency : human platelet Cdc42Hs GAP > p190 > Bem3 > break point cluster region protein , whereas p85 , like Bem2 , shows no GAP activity or any ability to bind to the GTP - bound form of Cdc42Hs .", "entity": [{"entity": "GST", "entity_type": "GENE", "pos": [32, 35]}, {"entity": "Bem3", "entity_type": "GENE", "pos": [38, 42]}, {"entity": "GAP", "entity_type": "GENE", "pos": [57, 60]}, {"entity": "Cdc42Hs", "entity_type": "GENE", "pos": [65, 72]}, {"entity": "rho", "entity_type": "GENE", "pos": [106, 109]}, {"entity": "GAP", "entity_type": "GENE", "pos": [112, 115]}, {"entity": "human platelet Cdc42Hs GAP", "entity_type": "GENE", "pos": [169, 195]}, {"entity": "p190", "entity_type": "GENE", "pos": [198, 202]}, {"entity": "Bem3", "entity_type": "GENE", "pos": [205, 209]}, {"entity": "break point cluster region protein", "entity_type": "GENE", "pos": [212, 246]}, {"entity": "p85", "entity_type": "GENE", "pos": [257, 260]}, {"entity": "Bem2", "entity_type": "GENE", "pos": [268, 272]}, {"entity": "GAP", "entity_type": "GENE", "pos": [284, 287]}, {"entity": "Cdc42Hs", "entity_type": "GENE", "pos": [347, 354]}], "task": "NER"}
{"text": "Through effective use of laboratory testing database , it will be possible to shift away our vague management of pre - analytic phase of quality control so far to its established system based on objective evaluation .", "entity": [], "task": "NER"}
{"text": "Nonlinearities in cochlear hydrodynamics .", "entity": [], "task": "NER"}
{"text": "The peptides are generated in the cytosol , then translocated across the membrane of the endoplasmic reticulum by the transporter associated with antigen processing ( TAP ) .", "entity": [{"entity": "transporter associated with antigen processing", "entity_type": "GENE", "pos": [118, 164]}, {"entity": "TAP", "entity_type": "GENE", "pos": [167, 170]}], "task": "NER"}
{"text": "An in vitro ' glass stomach ' ( containing various volumes of hydrochloric acid [ HCl ] and ammonium chloride [ NH4Cl ] ) was used to evaluate the means of increasing ' gastric ' pH to that of the NH4 + - - > NH3 transition that occurs significantly at pH 9 . 24 .", "entity": [], "task": "NER"}
{"text": "Moreover , a hybrid protein composed of a PvALF activation domain and the DNA binding and dimerization domain of ROM2 activated gene expression , indicating that ROM2 recognizes the DLEC2 enhancer in vivo ; consequently , ROM2 functions as a DNA binding site - dependent repressor .", "entity": [{"entity": "PvALF activation domain", "entity_type": "GENE", "pos": [42, 65]}, {"entity": "ROM2", "entity_type": "GENE", "pos": [113, 117]}, {"entity": "ROM2", "entity_type": "GENE", "pos": [162, 166]}, {"entity": "DLEC2 enhancer", "entity_type": "GENE", "pos": [182, 196]}, {"entity": "ROM2", "entity_type": "GENE", "pos": [222, 226]}], "task": "NER"}
{"text": "Northern analyses further confirm that the expression of endogenous alpha - ENaC gene in salivary Pa - 4 cells is suppressed by an ectopic HMGI - C overexpression .", "entity": [{"entity": "alpha - ENaC gene", "entity_type": "GENE", "pos": [68, 85]}, {"entity": "HMGI - C", "entity_type": "GENE", "pos": [139, 147]}], "task": "NER"}
{"text": "Finally , we demonstrated that although the DNA - binding domain of c - myb is required for both the differentiation block and the shift in cell cycle after PMA treatment , phosphorylation by casein kinase II and mitogen - activated protein kinase at positions 11 and 12 or 532 of c - myb , respectively , are not .", "entity": [{"entity": "c - myb", "entity_type": "GENE", "pos": [68, 75]}, {"entity": "casein kinase II", "entity_type": "GENE", "pos": [192, 208]}, {"entity": "mitogen - activated protein kinase", "entity_type": "GENE", "pos": [213, 247]}, {"entity": "c - myb", "entity_type": "GENE", "pos": [281, 288]}], "task": "NER"}
{"text": "We found that RXR and VDR transactivated selectively from VDRE - linked templates exclusively as a heterodimeric complex , since neither receptor alone enhanced transcription in vitro .", "entity": [{"entity": "RXR", "entity_type": "GENE", "pos": [14, 17]}, {"entity": "VDR", "entity_type": "GENE", "pos": [22, 25]}], "task": "NER"}
{"text": "We found a significant increase of thromboxane as evidenced by the major urinary metabolite 2 , 3 - dinorthromboxane B2 in the oestrogen group as compared to the orchidectomy group .", "entity": [], "task": "NER"}
{"text": "Assays of APRE - luciferase reporter plasmids transfected into HepG2 cells show that a mutated APRE that binds only BPi functions as an IL - 1 alpha inducible enhancer , whereas a mutated APRE that binds only BPc does not .", "entity": [{"entity": "luciferase", "entity_type": "GENE", "pos": [17, 27]}, {"entity": "BPi", "entity_type": "GENE", "pos": [116, 119]}, {"entity": "IL - 1 alpha", "entity_type": "GENE", "pos": [136, 148]}, {"entity": "BPc", "entity_type": "GENE", "pos": [209, 212]}], "task": "NER"}
{"text": "Compared with controls , patients in the unmedicated state had low smooth pursuit gain , had a higher rate of corrective catch - up saccades , and tended to spend less time engaged in the tracking task .", "entity": [], "task": "NER"}
{"text": "Epstein - Barr virus nuclear antigen 2 exerts its transactivating function through interaction with recombination signal binding protein RBP - J kappa , the homologue of Drosophila Suppressor of Hairless .", "entity": [{"entity": "Epstein - Barr virus nuclear antigen 2", "entity_type": "GENE", "pos": [0, 38]}, {"entity": "recombination signal binding protein RBP - J kappa", "entity_type": "GENE", "pos": [100, 150]}, {"entity": "Drosophila Suppressor of Hairless", "entity_type": "GENE", "pos": [170, 203]}], "task": "NER"}
{"text": "A . thaliana cystathionine beta - lyase exhibits 22 % sequence identity with the E . coli corresponding enzyme and contains a 70 amino acid N - terminal additional sequence compared with the bacterial protein .", "entity": [{"entity": "A . thaliana cystathionine beta - lyase", "entity_type": "GENE", "pos": [0, 39]}], "task": "NER"}
{"text": "The three - dimensional structure of the E . coli CR domain indicates that this sequence conservation is likely to result in a conserved structural motif .", "entity": [], "task": "NER"}
{"text": "Co - expression of PLD1 in COS - 7 cells with the two recombinant CK2 subunits , alpha or beta , suggests that the association of PLD1 with the kinase is through the beta subunit .", "entity": [{"entity": "PLD1", "entity_type": "GENE", "pos": [19, 23]}, {"entity": "recombinant CK2 subunits", "entity_type": "GENE", "pos": [54, 78]}, {"entity": "PLD1", "entity_type": "GENE", "pos": [130, 134]}], "task": "NER"}
{"text": "Despite this dependency , however , a B . japonicum fixK mutant did not have the phenotypic characteristics of B . japonicum fixL and fixJ mutants : the fixK mutant was neither Fix - in symbiosis with soybean plants nor defective in anaerobic respiration with nitrate as the terminal electron acceptor .", "entity": [{"entity": "B . japonicum fixK mutant", "entity_type": "GENE", "pos": [38, 63]}, {"entity": "B . japonicum fixL", "entity_type": "GENE", "pos": [111, 129]}, {"entity": "fixJ mutants", "entity_type": "GENE", "pos": [134, 146]}, {"entity": "fixK mutant", "entity_type": "GENE", "pos": [153, 164]}], "task": "NER"}
{"text": "The predicted amino acid sequence of Pst1p possessed high sequence homology with the Sin3 family of proteins , known for their interaction with histone deacetylases .", "entity": [{"entity": "Pst1p", "entity_type": "GENE", "pos": [37, 42]}, {"entity": "Sin3 family", "entity_type": "GENE", "pos": [85, 96]}, {"entity": "histone deacetylases", "entity_type": "GENE", "pos": [144, 164]}], "task": "NER"}
{"text": "This selective squelching activity suggests that GRIM can interact with an essential component of the RNA polymerase II transcription machinery .", "entity": [{"entity": "GRIM", "entity_type": "GENE", "pos": [49, 53]}, {"entity": "RNA polymerase II", "entity_type": "GENE", "pos": [102, 119]}], "task": "NER"}
{"text": "A third group ( n = 10 ) was assigned to receive the canalith repositioning maneuver without mastoid vibration .", "entity": [], "task": "NER"}
{"text": "With the help of partially overlapping parenchymatous sutures , different renal segments were devitalized .", "entity": [], "task": "NER"}
{"text": "The S . typhimurium aspartyl / asparaginyl beta - hydroxylase homologue ( designated lpxO ) was cloned into pBluescriptSK and expressed in Escherichia coli K - 12 , which does not contain lpxO .", "entity": [{"entity": "S . typhimurium aspartyl / asparaginyl beta - hydroxylase homologue", "entity_type": "GENE", "pos": [4, 71]}, {"entity": "lpxO", "entity_type": "GENE", "pos": [85, 89]}, {"entity": "lpxO", "entity_type": "GENE", "pos": [188, 192]}], "task": "NER"}
{"text": "Cardiac NE spillover was higher ( P < . 05 ) at baseline in the patient group than in healthy subjects , whereas renal and whole - body NE spillovers were similar between the study groups .", "entity": [], "task": "NER"}
{"text": "Translation of mok is tightly regulated by Sok RNA , and Sok RNA thus regulates hok translation indirectly through mok .", "entity": [{"entity": "mok", "entity_type": "GENE", "pos": [15, 18]}, {"entity": "Sok RNA", "entity_type": "GENE", "pos": [43, 50]}, {"entity": "Sok RNA", "entity_type": "GENE", "pos": [57, 64]}, {"entity": "hok", "entity_type": "GENE", "pos": [80, 83]}, {"entity": "mok", "entity_type": "GENE", "pos": [115, 118]}], "task": "NER"}
{"text": "In this work , we determined the sequences of eight VirF - binding sites from four different genes , by DNase I or hydroxyl radical footprinting .", "entity": [{"entity": "VirF - binding sites", "entity_type": "GENE", "pos": [52, 72]}, {"entity": "DNase I", "entity_type": "GENE", "pos": [104, 111]}], "task": "NER"}
{"text": "Treatment with ACE inhibitors after acute myocardial infarction", "entity": [{"entity": "ACE", "entity_type": "GENE", "pos": [15, 18]}], "task": "NER"}
{"text": "One - hour O3 , NO2 , and SO2 personal exposures were measured using samplers developed in our laboratory , while short - term PM2 . 5 , CO , and VOCs exposures were measured using currently available monitors .", "entity": [], "task": "NER"}
{"text": "Recombinant MsERK1 ( rMsERK1 ) , when overexpressed in Escherichia coli , is recognized by antibodies raised against MAP kinases from rat , Xenopus , and sea star and by anti - phosphotyrosine antibodies .", "entity": [{"entity": "Recombinant MsERK1", "entity_type": "GENE", "pos": [0, 18]}, {"entity": "rMsERK1", "entity_type": "GENE", "pos": [21, 28]}, {"entity": "MAP kinases from rat , Xenopus , and sea star", "entity_type": "GENE", "pos": [117, 162]}, {"entity": "anti - phosphotyrosine antibodies", "entity_type": "GENE", "pos": [170, 203]}], "task": "NER"}
{"text": "However , UV resistance is only minimally restored , and mutant cells remain sensitive to gamma radiation .", "entity": [], "task": "NER"}
{"text": "The melanoma growth stimulatory activity / growth - regulated protein , CXCL1 , is constitutively expressed at high levels during inflammation and progression of melanocytes into malignant melanoma .", "entity": [{"entity": "melanoma growth stimulatory activity / growth - regulated protein", "entity_type": "GENE", "pos": [4, 69]}, {"entity": "CXCL1", "entity_type": "GENE", "pos": [72, 77]}], "task": "NER"}
{"text": "The activated glucocorticoid receptor forms a complex with Stat5 and enhances Stat5 - mediated transcriptional induction .", "entity": [{"entity": "glucocorticoid receptor", "entity_type": "GENE", "pos": [14, 37]}, {"entity": "Stat5", "entity_type": "GENE", "pos": [59, 64]}, {"entity": "Stat5", "entity_type": "GENE", "pos": [78, 83]}], "task": "NER"}
{"text": "A simple procedure for accurate quantitation of factor VIII inhibitors .", "entity": [{"entity": "factor VIII", "entity_type": "GENE", "pos": [48, 59]}], "task": "NER"}
{"text": "Diagnostic importance of determining leucine aminotransferase activity in acute pancreatitis", "entity": [{"entity": "leucine aminotransferase", "entity_type": "GENE", "pos": [37, 61]}], "task": "NER"}
{"text": "In contrast , T229E - p70s6k migrated more slowly in SDS - polyacrylamide gels , but demonstrated partial kinase activity ( approximately 20 % compared with the wild type ) .", "entity": [{"entity": "T229E - p70s6k", "entity_type": "GENE", "pos": [14, 28]}], "task": "NER"}
{"text": "Transcription factor IIIC ( TFIIIC ) is required for the assembly of a preinitiation complex on 5S RNA , tRNA , and adenovirus VA RNA genes and contains two separable components , TFIIIC1 and TFIIIC2 .", "entity": [{"entity": "Transcription factor IIIC", "entity_type": "GENE", "pos": [0, 25]}, {"entity": "TFIIIC", "entity_type": "GENE", "pos": [28, 34]}, {"entity": "5S RNA", "entity_type": "GENE", "pos": [96, 102]}, {"entity": "adenovirus VA", "entity_type": "GENE", "pos": [116, 129]}, {"entity": "TFIIIC1", "entity_type": "GENE", "pos": [180, 187]}, {"entity": "TFIIIC2", "entity_type": "GENE", "pos": [192, 199]}], "task": "NER"}
{"text": "Synchronous multicentric giant cell tumour : a case report with review of literature .", "entity": [], "task": "NER"}
{"text": "Lysates of COS cells transfected with modified hGrzB cDNA were able to hydrolyze tert - butyloxycarbonyl - Ala - Ala - Asp - thiobenzyl ester ( Boc - Ala - Ala - Asp - SBzl ) , whereas lysates transfected with unmodified hGrzB cDNA were inactive .", "entity": [{"entity": "modified hGrzB cDNA", "entity_type": "GENE", "pos": [38, 57]}, {"entity": "unmodified hGrzB cDNA", "entity_type": "GENE", "pos": [210, 231]}], "task": "NER"}
{"text": "Mutant M proteins were tested for their ability to complement growth of the temperature - sensitive M protein mutant virus tsO23 at the nonpermissive temperature .", "entity": [{"entity": "Mutant M proteins", "entity_type": "GENE", "pos": [0, 17]}, {"entity": "M protein mutant", "entity_type": "GENE", "pos": [100, 116]}], "task": "NER"}
{"text": "The POU - specific domain of Pit - 1 is essential for sequence - specific , high affinity DNA binding and DNA - dependent Pit - 1 - Pit - 1 interactions .", "entity": [{"entity": "POU", "entity_type": "GENE", "pos": [4, 7]}, {"entity": "Pit - 1", "entity_type": "GENE", "pos": [29, 36]}, {"entity": "Pit - 1", "entity_type": "GENE", "pos": [122, 129]}, {"entity": "Pit - 1", "entity_type": "GENE", "pos": [132, 139]}], "task": "NER"}
{"text": "It competes with the calcium ion which brings about inhibition of myosine kinase , and therefore a drop in phosphorylated myosine .", "entity": [{"entity": "myosine kinase", "entity_type": "GENE", "pos": [66, 80]}], "task": "NER"}
{"text": "It appears to be useful in untreated patients with stage I or II NHL but no definite radiographic abnormalities , or with abnormal radiographs but no extrathoracic spread , and in treated patients with questionable radiographs .", "entity": [], "task": "NER"}
{"text": "We conclude that LGCS is successful in treating esophageal varices in the setting of hyperdynamic portal circulation with acceptable liver function .", "entity": [], "task": "NER"}
{"text": "3 ) The progress of fibrinolysis was observed by serial collection of middle ear fluid in the same side ear of 5 cases out of 17 cases having much activity for fibrin degradation , and lowering of fibrinolytic activity was revealed in 4 out of these 5 cases as the result .", "entity": [{"entity": "fibrin", "entity_type": "GENE", "pos": [20, 26]}], "task": "NER"}
{"text": "In lyzozyme activity there was periodicity in three groups but not in the youngest foals .", "entity": [{"entity": "lyzozyme", "entity_type": "GENE", "pos": [3, 11]}], "task": "NER"}
{"text": "Alternative roles of these DNA motifs as activators of early mRNA transcription and as an initiator element for late mRNA transcription help explain how polyomavirus gene expression is regulated during lytic growth and provides a model for cellular transcription during development .", "entity": [], "task": "NER"}
{"text": "The median levels of t - PA Ag and PAI in plasma were respectively 10 . 7 ng / ml ( interquartile range 8 . 6 ng / ml ) and 15 . 7 IU / ml ( interquartile range 12 . 2 IU / ml ) .", "entity": [{"entity": "t - PA Ag", "entity_type": "GENE", "pos": [21, 30]}, {"entity": "PAI", "entity_type": "GENE", "pos": [35, 38]}], "task": "NER"}
{"text": "The Mer1 protein contains the KH motif found in some RNA - binding proteins , and RNA gel mobility shift assays demonstrate that Mer1 binds specifically to MER2 RNA .", "entity": [{"entity": "Mer1 protein", "entity_type": "GENE", "pos": [4, 16]}, {"entity": "Mer1", "entity_type": "GENE", "pos": [129, 133]}, {"entity": "MER2 RNA", "entity_type": "GENE", "pos": [156, 164]}], "task": "NER"}
{"text": "Collectively , these studies suggest that the major EGF - stimulated mitotic growth pathways may not be absolutely linked to the stat91 signaling pathways and that such transcription complexes are more complex than previously reported .", "entity": [{"entity": "EGF", "entity_type": "GENE", "pos": [52, 55]}, {"entity": "stat91", "entity_type": "GENE", "pos": [129, 135]}], "task": "NER"}
{"text": "A procaryotic regulatory factor with a histone H1 - like carboxy - terminal domain : clonal variation of repeats within algP , a gene involved in regulation of mucoidy in Pseudomonas aeruginosa .", "entity": [{"entity": "histone H1 - like carboxy - terminal domain", "entity_type": "GENE", "pos": [39, 82]}, {"entity": "algP", "entity_type": "GENE", "pos": [120, 124]}], "task": "NER"}
{"text": "Innervation of reticular papillae in sheep and goats .", "entity": [], "task": "NER"}
{"text": "The monkeys had been administered a common lead isotope \" mix \" at the rate of about 1300 micrograms Pb / kg body wt / day from age 10 months until the start of the study .", "entity": [], "task": "NER"}
{"text": "Previous studies showed that a palindromic sequence located at - 159 base pairs is essential for induction of cutinase gene in Fusarium solani f . sp . pisi ( Nectria haematococca mating type VI ) by the hydroxy fatty acids from plant cutin and that a 50 - kDa nuclear protein binds to a promoter that contains this element .", "entity": [{"entity": "cutinase gene", "entity_type": "GENE", "pos": [110, 123]}], "task": "NER"}
{"text": "In cells co - expressing high levels of the p38 ( MAPK ) kinase ( MKK3 ) together with the p38 ( MAPK ) , a significant inhibition of mitogen - induced cyclin D1 expression was observed .", "entity": [{"entity": "p38", "entity_type": "GENE", "pos": [44, 47]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [50, 54]}, {"entity": "MKK3", "entity_type": "GENE", "pos": [66, 70]}, {"entity": "p38", "entity_type": "GENE", "pos": [91, 94]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [97, 101]}, {"entity": "cyclin D1", "entity_type": "GENE", "pos": [152, 161]}], "task": "NER"}
{"text": "ANL - 7535 .", "entity": [], "task": "NER"}
{"text": "Pig uPA promoter - CAT constructs were more active than mouse constructs in this assay .", "entity": [{"entity": "uPA", "entity_type": "GENE", "pos": [4, 7]}, {"entity": "CAT", "entity_type": "GENE", "pos": [19, 22]}], "task": "NER"}
{"text": "Thermal changes of the bovine uterus following administration of estradiol - 17beta .", "entity": [], "task": "NER"}
{"text": "Elements regulating cell - and stage - specific expression of the C . elegans MyoD family homolog hlh - 1 .", "entity": [{"entity": "MyoD", "entity_type": "GENE", "pos": [78, 82]}, {"entity": "hlh - 1", "entity_type": "GENE", "pos": [98, 105]}], "task": "NER"}
{"text": "Restriction analysis of the isolated genomic clones indicated that the endogenous sequences abutting the 3 ' ends of the 94 - A and 94 - K transgenes are separated by less than 20 kb , providing strong support for the single integration model .", "entity": [], "task": "NER"}
{"text": "The sensitivity for ergometry and treadmill testing was 75 and 62 % respectively .", "entity": [], "task": "NER"}
{"text": "All these abnormalities returned to normal after removal of the tumor .", "entity": [], "task": "NER"}
{"text": "The STS sequence WI - 14920 is in fact derived from the 3 ' - untranslated region of the human PUNC gene .", "entity": [{"entity": "STS sequence WI - 14920", "entity_type": "GENE", "pos": [4, 27]}, {"entity": "human PUNC gene", "entity_type": "GENE", "pos": [89, 104]}], "task": "NER"}
{"text": "Four antifungal agents were compared : amphotericin B , flucytosine , miconazole , and ketoconazole .", "entity": [], "task": "NER"}
{"text": "Phylogenetic analysis of yeast , invertebrate , and multiple mammalian isoforms of SNF4 shows that the gene duplication likely occurred early in the metazoan lineage , as the protein products of the different loci are relatively divergent .", "entity": [{"entity": "SNF4", "entity_type": "GENE", "pos": [83, 87]}], "task": "NER"}
{"text": "Blood samples ( 30 ml ) were collected via an indwelling arm catheter at rest , and at minutes 13 and 28 of exercise for determinations of plasma EPI , serum free fatty acid ( FFA ) , serum glycerol ( GLY ) , blood glucose ( GLU ) , and blood lactate ( LA ) concentrations .", "entity": [], "task": "NER"}
{"text": "The NF - kappa B precursor p100 ( lyt - 10 , p97 , p98 ) generates after proteolytic processing a 52 kDa subunit , which can bind to kappa B - motifs .", "entity": [{"entity": "NF - kappa B", "entity_type": "GENE", "pos": [4, 16]}, {"entity": "p100", "entity_type": "GENE", "pos": [27, 31]}, {"entity": "lyt - 10", "entity_type": "GENE", "pos": [34, 42]}, {"entity": "p97", "entity_type": "GENE", "pos": [45, 48]}, {"entity": "p98", "entity_type": "GENE", "pos": [51, 54]}, {"entity": "kappa B - motifs", "entity_type": "GENE", "pos": [133, 149]}], "task": "NER"}
{"text": "The delta mean VAF and delta mean SABP indicated varied mean values of VAF and SABP , respectively .", "entity": [], "task": "NER"}
{"text": "Gel mobility shift analyses reveal that FRTL - 5 thyroid cell nuclear extracts form a specific protein / DNA complex with this region , which is prevented by the TTF - 1 binding element from the TG promoter ; FRT and BRL cell nuclear extracts do not have TTF - 1 and do not form this complex .", "entity": [{"entity": "TTF - 1 binding element", "entity_type": "GENE", "pos": [162, 185]}, {"entity": "TG promoter", "entity_type": "GENE", "pos": [195, 206]}, {"entity": "TTF - 1", "entity_type": "GENE", "pos": [255, 262]}], "task": "NER"}
{"text": "The rice gene consists of four exons .", "entity": [], "task": "NER"}
{"text": "Thallium - 201 scintigraphy after dipyridamole infusion with low level exercise .", "entity": [], "task": "NER"}
{"text": "Dominant - negative upf1 mutations were isolated following in vitro mutagenesis of a plasmid containing the UPF1 gene .", "entity": [{"entity": "upf1", "entity_type": "GENE", "pos": [20, 24]}, {"entity": "UPF1 gene", "entity_type": "GENE", "pos": [108, 117]}], "task": "NER"}
{"text": "One of the ORFs in the Methanococcus jannaschii genome possesses high similarity to the M . aeolicus ilvB , indicating that it is an authentic AHAS .", "entity": [{"entity": "M . aeolicus ilvB", "entity_type": "GENE", "pos": [88, 105]}, {"entity": "AHAS", "entity_type": "GENE", "pos": [143, 147]}], "task": "NER"}
{"text": "It differed from cued recall only in the instructions , which directed subjects away from the memory aspects of the test and asked them to complete each three - letter cue with the first word that came to mind .", "entity": [], "task": "NER"}
{"text": "Such saturation often occurs for several recording sweeps after large amplitude signals such as eye blinks are rejected .", "entity": [], "task": "NER"}
{"text": "To define the molecular mechanism regulating FGFR - 1 gene expression in proliferating myoblasts and post - mitotic muscle fibers , we have isolated and partially characterized the avian FGFR - 1 gene promoter .", "entity": [{"entity": "FGFR - 1 gene", "entity_type": "GENE", "pos": [45, 58]}, {"entity": "FGFR - 1 gene", "entity_type": "GENE", "pos": [187, 200]}], "task": "NER"}
{"text": "Samarium - 153 for intravascular irradiation therapy with liquid - filled balloons to prevent restenosis : acute and long - term results in a hypercholesterolemic rabbit restenosis model .", "entity": [], "task": "NER"}
{"text": "This element was required for both basal and activated expression and almost certainly functions as a TATA - binding protein interaction site .", "entity": [{"entity": "TATA - binding protein", "entity_type": "GENE", "pos": [102, 124]}], "task": "NER"}
{"text": "This report establishes that the effect of homozygous sickle cell disease on growth patterns in childhood is apparent before the age of 6 years .", "entity": [], "task": "NER"}
{"text": "But it is possible that the two hemispheres differ in the manner in which they make use of semantic structures : the left hemisphere in a selective manner , appropriate for the solution of a specific task , and the right hemisphere in a more diffuse and global manner .", "entity": [], "task": "NER"}
{"text": "The results reveal preferences for particular initiating nucleotides ( ATP > or = GTP > UTP > > CTP ) and for starting positions downstream of the Pribnow box ( 7 > > 6 and 8 > 9 > 10 ) .", "entity": [], "task": "NER"}
{"text": "We determined that Hop ( T42 ) contains a glutamic acid - to - lysine substitution at amino acid residue 695 ( E695K ) .", "entity": [{"entity": "Hop ( T42 )", "entity_type": "GENE", "pos": [19, 30]}], "task": "NER"}
{"text": "Androgen ablation - - 50 years later .", "entity": [], "task": "NER"}
{"text": "It is suggested that on presentation of tail tip necrosis in kittens a diagnosis of neonatal isoerythrolysis or isoagglutination should be considered .", "entity": [], "task": "NER"}
{"text": "Men and women entering psychotherapy more often had negative Wish elements than others .", "entity": [], "task": "NER"}
{"text": "This clone will be useful for identifying the genetic determinants of FIV - Oma ' s biological activities .", "entity": [], "task": "NER"}
{"text": "Serum prolactin and oestradiol levels at different stages of puberty .", "entity": [{"entity": "Serum prolactin", "entity_type": "GENE", "pos": [0, 15]}], "task": "NER"}
{"text": "The sequence of three of them revealed pure CAG stretches .", "entity": [], "task": "NER"}
{"text": "Total body BMD ( r = 0 . 30 ; P = 0 . 02 ) and femoral neck BMD ( r = 0 . 39 ; P = 0 . 002 ) were positively correlated with weight - bearing activity but not with non - weight - bearing activity .", "entity": [], "task": "NER"}
{"text": "PCC 6803 mutant impaired in cytochrome c maturation .", "entity": [{"entity": "cytochrome c", "entity_type": "GENE", "pos": [28, 40]}], "task": "NER"}
{"text": "Ureases were purified from the recombinant cells and shown to be identical to control enzyme when analyzed by gel filtration chromatography and sodium dodecyl sulfate - polyacrylamide gel electrophoresis ; however , in every case the activity levels correlated to nickel contents as analyzed by atomic absorption analysis .", "entity": [{"entity": "Ureases", "entity_type": "GENE", "pos": [0, 7]}], "task": "NER"}
{"text": "Sequence analysis of the catfish JH - CH intron suggests that several sequences are present which appear similar to important transcriptional regulatory elements found within JH - CH introns of higher vertebrates .", "entity": [{"entity": "JH", "entity_type": "GENE", "pos": [33, 35]}, {"entity": "CH", "entity_type": "GENE", "pos": [38, 40]}, {"entity": "JH", "entity_type": "GENE", "pos": [175, 177]}, {"entity": "CH", "entity_type": "GENE", "pos": [180, 182]}], "task": "NER"}
{"text": "Seroconversion after hepatitis B vaccination .", "entity": [], "task": "NER"}
{"text": "On day 1 at 3500 m , RI showed a significant fall in body weight ( BW ) with respect to SL but AI maintained it .", "entity": [], "task": "NER"}
{"text": "Expression of CBP / p300 potentiated HS2 - mediated transactivation .", "entity": [{"entity": "CBP", "entity_type": "GENE", "pos": [14, 17]}, {"entity": "p300", "entity_type": "GENE", "pos": [20, 24]}], "task": "NER"}
{"text": "The perforated splint gives superior results by virtue of the fact that it does not require to be removed for purposes of hygiene and can thus produce a satisfactory result even in those patients who fail to grasp the technique of removal and replacement of the splint .", "entity": [], "task": "NER"}
{"text": "Using lasers in diabetic wound healing .", "entity": [], "task": "NER"}
{"text": "Protein metabolism disorders in burns", "entity": [], "task": "NER"}
{"text": "In contrast , MAPK activation stimulated by the Gq - coupled alpha 1B AR or M1 muscarinic cholinergic receptor is unaffected by expression of beta ARKct or RasN17 expression or by PTK inhibitors , but is blocked by expression of N delta Raf or by PKC depletion .", "entity": [{"entity": "MAPK", "entity_type": "GENE", "pos": [14, 18]}, {"entity": "Gq", "entity_type": "GENE", "pos": [48, 50]}, {"entity": "M1", "entity_type": "GENE", "pos": [76, 78]}, {"entity": "muscarinic cholinergic receptor", "entity_type": "GENE", "pos": [79, 110]}, {"entity": "beta ARKct", "entity_type": "GENE", "pos": [142, 152]}, {"entity": "RasN17", "entity_type": "GENE", "pos": [156, 162]}, {"entity": "PTK", "entity_type": "GENE", "pos": [180, 183]}, {"entity": "N delta Raf", "entity_type": "GENE", "pos": [229, 240]}, {"entity": "PKC", "entity_type": "GENE", "pos": [247, 250]}], "task": "NER"}
{"text": "RNA unwinding in U4 / U6 snRNPs requires ATP hydrolysis and the DEIH - box splicing factor Brr2 .", "entity": [{"entity": "U4", "entity_type": "GENE", "pos": [17, 19]}, {"entity": "U6", "entity_type": "GENE", "pos": [22, 24]}, {"entity": "Brr2", "entity_type": "GENE", "pos": [91, 95]}], "task": "NER"}
{"text": "Extra dose due to extravehicular activity during the NASA4 mission measured by an on - board TLD system .", "entity": [], "task": "NER"}
{"text": "Preface and acknowledgements .", "entity": [], "task": "NER"}
{"text": "G - CSF ( 10 microg / kg ) was started on day + 1 and all patients engrafted within a median day number of 12 ( range , 10 - 22 ) until leukocytes > 1 . 0 x 10 ( 9 ) / l and a median day number of 56 ( range , 10 - 180 ) until platelets > 20 . 0 x 10 ( 9 ) / l ( ie platelet transfusion independence ) .", "entity": [{"entity": "G - CSF", "entity_type": "GENE", "pos": [0, 7]}], "task": "NER"}
{"text": "The present study indicates that the high - dose 5 - fluorouracil regimen shows weak activity in advanced pancreatic cancer which seems comparable to gemcitabine .", "entity": [], "task": "NER"}
{"text": "At D28 , 149 of 386 patients ( 49 % ) had had episodes of automatic mode switch prompted by atrial arrhythmias .", "entity": [], "task": "NER"}
{"text": "Thus , the rates of a - factor receptor endocytosis and consequent vacuolar turnover depend on the available level of ubiquitin in the cell .", "entity": [{"entity": "a - factor receptor", "entity_type": "GENE", "pos": [20, 39]}, {"entity": "ubiquitin", "entity_type": "GENE", "pos": [118, 127]}], "task": "NER"}
{"text": "Early diagnosis and early surgical division of the biliary tract and pancreatic duct is recommended for children with AAPBD .", "entity": [], "task": "NER"}
{"text": "This approach allowed examination of baseline factors as well as the effect of change in mileage , the occurrence of a musculoskeletal problem , or the occurrence of another health problem on the rate of dropout .", "entity": [], "task": "NER"}
{"text": "Increased gliadin antibody levels were found more frequently in patients with subtotal villous atrophy ( 9 out of 17 patients , or 53 % ; p less than 0 . 05 ) than in patients with partial villous atrophy ( 2 out of 13 patients , or 15 % ) or normal villous appearance ( 2 out of 10 patients , or 20 % ) .", "entity": [{"entity": "gliadin antibody", "entity_type": "GENE", "pos": [10, 26]}], "task": "NER"}
{"text": "The effects of cefazolin , given into the III cerebral ventricle at different doses were studied on GABA content , GAD and GABA - T in the brain - stem of young chickens ( Gallus domesticus ) .", "entity": [], "task": "NER"}
{"text": "This sequence was sufficient to confer p53 - dependent activation to a heterologous promoter and p53 was capable of binding to this sequence as assessed by gel shift analysis .", "entity": [{"entity": "p53", "entity_type": "GENE", "pos": [39, 42]}, {"entity": "p53", "entity_type": "GENE", "pos": [97, 100]}], "task": "NER"}
{"text": "CAT assays demonstrated that overexpression of RXRalpha conferred the best RA response , consistent with our previous observation that 9 - cis - RA is more potent than all - trans - RA for inducing the expression of the AFP gene .", "entity": [{"entity": "CAT", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "RXRalpha", "entity_type": "GENE", "pos": [47, 55]}, {"entity": "AFP gene", "entity_type": "GENE", "pos": [220, 228]}], "task": "NER"}
{"text": "In addition , the results suggest that N region diversity at V ( D ) J junctions within rearranged immunoglobulin and T cell receptor gene loci can only be introduced after the generation of RAG - catalyzed DNA double - strand breaks , i . e . during the DNA end joining phase of the V ( D ) J recombination reaction .", "entity": [{"entity": "V", "entity_type": "GENE", "pos": [61, 62]}, {"entity": "D", "entity_type": "GENE", "pos": [65, 66]}, {"entity": "J", "entity_type": "GENE", "pos": [69, 70]}, {"entity": "immunoglobulin", "entity_type": "GENE", "pos": [99, 113]}, {"entity": "T cell receptor gene loci", "entity_type": "GENE", "pos": [118, 143]}, {"entity": "RAG", "entity_type": "GENE", "pos": [191, 194]}, {"entity": "V", "entity_type": "GENE", "pos": [284, 285]}, {"entity": "D", "entity_type": "GENE", "pos": [288, 289]}, {"entity": "J", "entity_type": "GENE", "pos": [292, 293]}], "task": "NER"}
{"text": "The pra2 gene encodes a pea ( Pisum sativum ) small GTPase belonging to the YPT / rab family , and its expression is down - regulated by light , mediated by phytochrome .", "entity": [{"entity": "pra2 gene", "entity_type": "GENE", "pos": [4, 13]}, {"entity": "pea ( Pisum sativum ) small GTPase", "entity_type": "GENE", "pos": [24, 58]}, {"entity": "YPT", "entity_type": "GENE", "pos": [76, 79]}, {"entity": "rab", "entity_type": "GENE", "pos": [82, 85]}, {"entity": "phytochrome", "entity_type": "GENE", "pos": [157, 168]}], "task": "NER"}
{"text": "To directly address this issue , we used a tetracycline - regulated system in human U2OS osteosarcoma cells and thus found that BCL6 mediates growth suppression associated with impaired S phase progression and apoptosis .", "entity": [{"entity": "BCL6", "entity_type": "GENE", "pos": [128, 132]}], "task": "NER"}
{"text": "Changes in water and electrolyte content of the brain and edema formation after acute , drug - induced hypertension were studied in albino rabbits .", "entity": [], "task": "NER"}
{"text": "The amino - terminal gag - encoded region of P140gag - fps contains a phosphotyrosine residue in addition to normal gag phosphorylation sites .", "entity": [{"entity": "amino - terminal gag - encoded region", "entity_type": "GENE", "pos": [4, 41]}, {"entity": "P140gag", "entity_type": "GENE", "pos": [45, 52]}, {"entity": "fps", "entity_type": "GENE", "pos": [55, 58]}, {"entity": "gag", "entity_type": "GENE", "pos": [116, 119]}], "task": "NER"}
{"text": "To explore the effect of persistent cardiomegaly on cardiovascular function , groups of newborn rats inhaled up to 500 ppm CO for 33 days , after which development continued in ambient air .", "entity": [], "task": "NER"}
{"text": "The subjects ' lungs were ventilated with N2O in O2 ( FIO2 0 . 3 ) to the end - tidal CO2 present before anesthesia , and then CBF was measured using intravenous 133Xe and ten scintillation counters , five over each cerebral hemisphere .", "entity": [], "task": "NER"}
{"text": "Cutaneous melanoma and bilateral retinoblastoma .", "entity": [], "task": "NER"}
{"text": "This complex was eliminated by mutation of either half - site , and it was supershifted by antibodies against chicken ovalbumin upstream promoter - transcription factor ( COUP - TF ) .", "entity": [{"entity": "chicken ovalbumin upstream promoter - transcription factor", "entity_type": "GENE", "pos": [110, 168]}, {"entity": "COUP - TF", "entity_type": "GENE", "pos": [171, 180]}], "task": "NER"}
{"text": "Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses .", "entity": [{"entity": "CCR5 genes", "entity_type": "GENE", "pos": [21, 31]}], "task": "NER"}
{"text": "The transcription start site was localized 224 bp upstream the ATG codon by RNase protection and primer extension mapping .", "entity": [{"entity": "RNase", "entity_type": "GENE", "pos": [76, 81]}], "task": "NER"}
{"text": "Statistical aspects of the relation of the radioprotective action of mercaptoethylamine derivatives and analogs to their electron parameters", "entity": [], "task": "NER"}
{"text": "Six patients ( 24 % ) developed sepsis and only one survived .", "entity": [], "task": "NER"}
{"text": "The material then was cut with a diamond saw into sheets of 8 x 10 x 3 mm , and the upper surface was polished by colloidal SiO2 and / or covered with a carbon - titanium ( C : Ti ) layer ( 3 . 3 microm ) using the plasma - enhanced physical vapor deposition method .", "entity": [], "task": "NER"}
{"text": "We present here a statistical technique we developed to identify the sequence elements that may be responsible for this cell cycle regulation .", "entity": [], "task": "NER"}
{"text": "Diabetic osteopenia , a known chronic complication of diabetes , has been demonstrated with alterations in the calcium - vitamin D endocrine system .", "entity": [], "task": "NER"}
{"text": "From the comparison of the nod box sequences of ( brady ) rhizobia with a more divergent nod box from Azorhizobium caulinodans , we now propose a modular build - up of the nod box with the sequence A - T - C - N9 - G - A - T as the binding target of the NodD protein ( the NodD box ) .", "entity": [{"entity": "nod box sequences", "entity_type": "GENE", "pos": [27, 44]}, {"entity": "nod box", "entity_type": "GENE", "pos": [89, 96]}, {"entity": "nod box", "entity_type": "GENE", "pos": [172, 179]}, {"entity": "NodD protein", "entity_type": "GENE", "pos": [254, 266]}, {"entity": "NodD box", "entity_type": "GENE", "pos": [273, 281]}], "task": "NER"}
{"text": "This dip also occurred during prednisone and vitamin D treatment , but did not occur when calcium was added to prednisone , although the baseline value was lower at the start of combined treatment with prednisone and calcium .", "entity": [], "task": "NER"}
{"text": "Highly conserved regions called src homology 2 and 3 ( SH2 and SH3 ) , comprising amino acid residues 88 to 250 , are believed to modulate the protein - tyrosine kinase activity present in the carboxy - terminal halves of the src proteins .", "entity": [{"entity": "src homology 2", "entity_type": "GENE", "pos": [32, 46]}, {"entity": "SH2", "entity_type": "GENE", "pos": [55, 58]}, {"entity": "SH3", "entity_type": "GENE", "pos": [63, 66]}, {"entity": "protein - tyrosine kinase", "entity_type": "GENE", "pos": [143, 168]}, {"entity": "src proteins", "entity_type": "GENE", "pos": [226, 238]}], "task": "NER"}
{"text": "The addition of novel techniques , such as histopathologic ultrastaging , immunohistochemistry staining , and reverse transcriptase polymerase chain reaction assays , will help increase the accuracy and rate of detection of disease .", "entity": [{"entity": "reverse transcriptase", "entity_type": "GENE", "pos": [110, 131]}], "task": "NER"}
{"text": "Acanthamoeba myosin I heavy chain kinase ( MIHCK ) phosphorylates the heavy chains of amoeba myosins I , increasing their actin - activated ATPase activities .", "entity": [{"entity": "Acanthamoeba myosin I heavy chain kinase", "entity_type": "GENE", "pos": [0, 40]}, {"entity": "MIHCK", "entity_type": "GENE", "pos": [43, 48]}, {"entity": "amoeba myosins I", "entity_type": "GENE", "pos": [86, 102]}, {"entity": "actin", "entity_type": "GENE", "pos": [122, 127]}, {"entity": "ATPase", "entity_type": "GENE", "pos": [140, 146]}], "task": "NER"}
{"text": "Two different genes ( polA and polB ) encoding family B DNA polymerases were cloned from the organism by PCR using degenerated primers based on the two conserved motifs ( motif A and B ) .", "entity": [{"entity": "polA", "entity_type": "GENE", "pos": [22, 26]}, {"entity": "polB", "entity_type": "GENE", "pos": [31, 35]}, {"entity": "family B DNA polymerases", "entity_type": "GENE", "pos": [47, 71]}], "task": "NER"}
{"text": "In this reconstituted system , RNAP IIA , but not RNAP IIB , can transcribe from the DHFR promoter .", "entity": [{"entity": "RNAP IIA", "entity_type": "GENE", "pos": [31, 39]}, {"entity": "RNAP IIB", "entity_type": "GENE", "pos": [50, 58]}, {"entity": "DHFR promoter", "entity_type": "GENE", "pos": [85, 98]}], "task": "NER"}
{"text": "Furthermore , the data suggest an immunological non - responsiveness to enterotoxin A in a considerable portion of the patients .", "entity": [{"entity": "enterotoxin A", "entity_type": "GENE", "pos": [72, 85]}], "task": "NER"}
{"text": "The polypeptide encoded by the cDNA contained 450 amino acids with a calculated M ( r ) of 52 , 057 , and showed significant homology with human and mouse CAD ( 22 % identity ) .", "entity": [{"entity": "mouse CAD", "entity_type": "GENE", "pos": [149, 158]}], "task": "NER"}
{"text": "Focal or regional 8 - to 20 - Hz low - voltage epileptiform paroxysms in either hippocampus ( 10 patients ) , amygdala ( 1 patient ) , or both ( 1 patient ) preceded initial motionless staring .", "entity": [], "task": "NER"}
{"text": "Cytokine - mediated I kappa B alpha reappearance was completely blocked by the protein synthesis inhibitor cycloheximide .", "entity": [{"entity": "I kappa B alpha", "entity_type": "GENE", "pos": [20, 35]}], "task": "NER"}
{"text": "In addition , the authors found one an3 allele ( an3 - W138A ) in which a dTph1 element had inserted 30 bp upstream the translation start , without inactivating the gene .", "entity": [{"entity": "an3 allele", "entity_type": "GENE", "pos": [36, 46]}, {"entity": "an3 - W138A", "entity_type": "GENE", "pos": [49, 60]}, {"entity": "dTph1 element", "entity_type": "GENE", "pos": [74, 87]}], "task": "NER"}
{"text": "The right cornea of rats was cauterized by drops of 1 . 5 N HC1 over 30 s ; the left one served as a control .", "entity": [], "task": "NER"}
{"text": "The difference between the effects of the two dose levels of Z .", "entity": [], "task": "NER"}
{"text": "The purpose of this presentation is to review the current state of knowledge regarding 5 , 8 , 11 , 14 - eicosatetraynoic acid ( ETYA , Ro 3 - 1428 ) and its effects on lipid metabolism .", "entity": [], "task": "NER"}
{"text": "Pathophysiologic mechanisms underlying spatial disorientation in patients with Alzheimer ' s disease .", "entity": [], "task": "NER"}
{"text": "Secretion of cuticle over and between the domed apical surfaces of these cells leads to a honeycomb - like structure and gives the superficial wart - like phenotype of mitotic clones on the adult .", "entity": [], "task": "NER"}
{"text": "The sequences of two previously known tail genes , R and S , of the temperate bacteriophage P2 and the sequence of an additional open reading frame ( orf - 30 ) located between S and V , were determined .", "entity": [{"entity": "tail genes", "entity_type": "GENE", "pos": [38, 48]}, {"entity": "R", "entity_type": "GENE", "pos": [51, 52]}, {"entity": "S", "entity_type": "GENE", "pos": [57, 58]}, {"entity": "S", "entity_type": "GENE", "pos": [177, 178]}, {"entity": "V", "entity_type": "GENE", "pos": [183, 184]}], "task": "NER"}
{"text": "NGF also induced a synthetic promoter with repeated Sp1 sites linked to a core promoter , and a plasmid regulated by a chimeric transactivator in which the Gal4 DNA binding domain is fused to the Sp1 transactivation domain , indicating that this transactivation domain is regulated by NGF .", "entity": [{"entity": "NGF", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "Sp1 sites", "entity_type": "GENE", "pos": [52, 61]}, {"entity": "Gal4 DNA binding domain", "entity_type": "GENE", "pos": [156, 179]}, {"entity": "Sp1 transactivation domain", "entity_type": "GENE", "pos": [196, 222]}, {"entity": "NGF", "entity_type": "GENE", "pos": [285, 288]}], "task": "NER"}
{"text": "Nuclear transcription assays confirmed that cys - 3 + was under sulfur - regulated transcriptional control and that cys - 3 + transcription was constitutive in sulfur controller ( scon ) - negative regulator mutants .", "entity": [{"entity": "cys - 3 +", "entity_type": "GENE", "pos": [44, 53]}, {"entity": "cys - 3 +", "entity_type": "GENE", "pos": [116, 125]}, {"entity": "sulfur controller", "entity_type": "GENE", "pos": [160, 177]}, {"entity": "scon", "entity_type": "GENE", "pos": [180, 184]}], "task": "NER"}
{"text": "These results suggest that UvrA is involved in triplet repeat instability in cells .", "entity": [{"entity": "UvrA", "entity_type": "GENE", "pos": [27, 31]}], "task": "NER"}
{"text": "We conclude , therefore , that in the absence of E1A , E4orf4 is sufficient by itself to trigger a p53 - independent apoptosis pathway that may operate independently of the known zVAD - inhibitable caspases , and that may involve an as yet uncharacterized mechanism .", "entity": [{"entity": "E1A", "entity_type": "GENE", "pos": [49, 52]}, {"entity": "E4orf4", "entity_type": "GENE", "pos": [55, 61]}, {"entity": "p53", "entity_type": "GENE", "pos": [99, 102]}, {"entity": "caspases", "entity_type": "GENE", "pos": [198, 206]}], "task": "NER"}
{"text": "CONCLUSIONS : The system developed in this study can be used as a method to detect air - trapping during TGI .", "entity": [], "task": "NER"}
{"text": "The nucleotide sequence of the gene encoding this product was determined and the amino acid sequence deduced .", "entity": [], "task": "NER"}
{"text": "After a shift to 37 degrees C , the mutant Rat7 - 1p / Nup159 - 1p is lost from the nuclear rim of rat7 - 1 cells and NPCs , which are clustered together in these cells grown under permissive conditions become substantially less clustered .", "entity": [{"entity": "Rat7 - 1p", "entity_type": "GENE", "pos": [43, 52]}, {"entity": "Nup159 - 1p", "entity_type": "GENE", "pos": [55, 66]}], "task": "NER"}
{"text": "Evidence for Gcr1p / Gcr2p interaction has been presented earlier and is now supported by the isolation of mutations in Gcr1p suppressing gcr2 , as assessed by growth and enzyme assay .", "entity": [{"entity": "Gcr1p", "entity_type": "GENE", "pos": [13, 18]}, {"entity": "Gcr2p", "entity_type": "GENE", "pos": [21, 26]}, {"entity": "Gcr1p", "entity_type": "GENE", "pos": [120, 125]}, {"entity": "gcr2", "entity_type": "GENE", "pos": [138, 142]}], "task": "NER"}
{"text": "Renal function was evaluated in a group of 24 patients ( 21 men and 3 women , mean age 47 years ) who had survived the malignant phase of hypertension during the period of 1969 - 1979 .", "entity": [], "task": "NER"}
{"text": "Mammalian ribonucleotide reductase shows S - phase specific expression and consists of two non - identical subunits , proteins R1 ( large subunit ) and R2 ( small subunit ) .", "entity": [{"entity": "ribonucleotide reductase", "entity_type": "GENE", "pos": [10, 34]}, {"entity": "proteins R1", "entity_type": "GENE", "pos": [118, 129]}, {"entity": "R2", "entity_type": "GENE", "pos": [152, 154]}], "task": "NER"}
{"text": "Azoospermia was graded in the following way : adequate spermatozoa ( A1 ) , low , scanty or rare spermatozoa ( A2 ) , spermatid arrest ( B1 ) , spermatocyte arrest ( B2 ) , Sertoli cell - only pattern ( C ) and sclerosis ( D ) .", "entity": [], "task": "NER"}
{"text": "This paper describes a course of therapy with an agoraphobic female patient .", "entity": [], "task": "NER"}
{"text": "Plasmids bearing the P . stipitis URA3 gene and ARS2 element produced more than 30 , 000 transformants per micrograms of plasmid DNA .", "entity": [{"entity": "P . stipitis URA3 gene", "entity_type": "GENE", "pos": [21, 43]}], "task": "NER"}
{"text": "The activation of NF - kappaB - dependent reporter gene transcription by E1A was potently suppressed upon coexpression of the E1B 19 - kDa protein ( 19K ) .", "entity": [{"entity": "NF - kappaB", "entity_type": "GENE", "pos": [18, 29]}, {"entity": "E1A", "entity_type": "GENE", "pos": [73, 76]}, {"entity": "E1B 19 - kDa protein ( 19K )", "entity_type": "GENE", "pos": [126, 154]}], "task": "NER"}
{"text": "We analyzed the effects of light on tubulin mRNA abundance in Arabidopsis seedlings using RNA gel blot hybridizations and gene - specific probes .", "entity": [{"entity": "tubulin mRNA", "entity_type": "GENE", "pos": [36, 48]}], "task": "NER"}
{"text": "We conclude that transcription of both SCD1 and SCD2 genes is responsive to cellular sterol levels and to the levels of nuclear SREBP / ADD1 and that transcriptional induction requires three spatially conserved cis elements , that bind SREBP and NF - Y .", "entity": [{"entity": "SCD1", "entity_type": "GENE", "pos": [39, 43]}, {"entity": "SCD2 genes", "entity_type": "GENE", "pos": [48, 58]}, {"entity": "SREBP", "entity_type": "GENE", "pos": [128, 133]}, {"entity": "ADD1", "entity_type": "GENE", "pos": [136, 140]}, {"entity": "SREBP", "entity_type": "GENE", "pos": [236, 241]}, {"entity": "NF - Y", "entity_type": "GENE", "pos": [246, 252]}], "task": "NER"}
{"text": "BACKGROUND : Recent iterative methods for sequence alignment have indicated that the 380 kDa motor unit of dynein belongs to the AAA class of chaperone - like ATPases .", "entity": [{"entity": "dynein", "entity_type": "GENE", "pos": [107, 113]}, {"entity": "AAA class", "entity_type": "GENE", "pos": [129, 138]}, {"entity": "chaperone - like ATPases", "entity_type": "GENE", "pos": [142, 166]}], "task": "NER"}
{"text": "It is suggested that death of S . mansoni cercariae during penetration of mammalian host skin is probably due to exhaustion of their energy reserves .", "entity": [], "task": "NER"}
{"text": "In particular , lacZ transcripts synthesised this way are highly unstable and yield little beta - galactosidase .", "entity": [{"entity": "lacZ transcripts", "entity_type": "GENE", "pos": [16, 32]}, {"entity": "beta - galactosidase", "entity_type": "GENE", "pos": [91, 111]}], "task": "NER"}
{"text": "Recent research on lipolysis .", "entity": [], "task": "NER"}
{"text": "Instead , HBx is shown to activate the cyclin A promoter , induce cyclin A - cyclin - dependent kinase 2 complexes , and promote cycling of growth - arrested cells into G1 through a pathway involving activation of Src tyrosine kinases .", "entity": [{"entity": "HBx", "entity_type": "GENE", "pos": [10, 13]}, {"entity": "cyclin A promoter", "entity_type": "GENE", "pos": [39, 56]}, {"entity": "cyclin A", "entity_type": "GENE", "pos": [66, 74]}, {"entity": "cyclin - dependent kinase 2", "entity_type": "GENE", "pos": [77, 104]}, {"entity": "Src tyrosine kinases", "entity_type": "GENE", "pos": [214, 234]}], "task": "NER"}
{"text": "Fifty - seven per cent of the primary patients reporting mild symptoms had abnormal levels of leucocytes in their CSF .", "entity": [], "task": "NER"}
{"text": "The vertebrate transcription factors TCF ( T cell factor ) and LEF ( lymphocyte enhancer binding factor ) interact with beta - catenin and are hypothesized to mediate Wingless / Wnt signaling .", "entity": [{"entity": "vertebrate transcription factors TCF", "entity_type": "GENE", "pos": [4, 40]}, {"entity": "T cell factor", "entity_type": "GENE", "pos": [43, 56]}, {"entity": "LEF", "entity_type": "GENE", "pos": [63, 66]}, {"entity": "lymphocyte enhancer binding factor", "entity_type": "GENE", "pos": [69, 103]}, {"entity": "beta - catenin", "entity_type": "GENE", "pos": [120, 134]}, {"entity": "Wingless", "entity_type": "GENE", "pos": [167, 175]}, {"entity": "Wnt", "entity_type": "GENE", "pos": [178, 181]}], "task": "NER"}
{"text": "DESIGN : Activating protein - 1 ( AP - 1 ) and Tat - induced transcription were assessed using Jun and hybrid Tat / Jun - expression plasmids and reporter gene constructs which contained AP - 1 binding sites upstream of the rat prolactin TATAA element or an HIV - 1 LTR construct in which AP - 1 binding sites replaced the TAR element .", "entity": [{"entity": "Activating protein - 1", "entity_type": "GENE", "pos": [9, 31]}, {"entity": "AP - 1", "entity_type": "GENE", "pos": [34, 40]}, {"entity": "Tat", "entity_type": "GENE", "pos": [47, 50]}, {"entity": "Jun", "entity_type": "GENE", "pos": [95, 98]}, {"entity": "Tat", "entity_type": "GENE", "pos": [110, 113]}, {"entity": "Jun", "entity_type": "GENE", "pos": [116, 119]}, {"entity": "AP - 1 binding sites", "entity_type": "GENE", "pos": [187, 207]}, {"entity": "rat prolactin TATAA element", "entity_type": "GENE", "pos": [224, 251]}, {"entity": "HIV - 1 LTR construct", "entity_type": "GENE", "pos": [258, 279]}, {"entity": "AP - 1 binding sites", "entity_type": "GENE", "pos": [289, 309]}], "task": "NER"}
{"text": "The PRP4 protein of Saccharomyces cerevisiae is an essential part of the U4 / U6 snRNP , a component of the mRNA splicing apparatus .", "entity": [{"entity": "PRP4 protein of Saccharomyces cerevisiae", "entity_type": "GENE", "pos": [4, 44]}, {"entity": "U4", "entity_type": "GENE", "pos": [73, 75]}, {"entity": "U6", "entity_type": "GENE", "pos": [78, 80]}], "task": "NER"}
{"text": "According to the penetration of Ca - 45 , the microleakage level was scored for each section .", "entity": [], "task": "NER"}
{"text": "Endothelial purine content .", "entity": [], "task": "NER"}
{"text": "Binding of transformed Ah receptor complex to a dioxin responsive transcriptional enhancer : evidence for two distinct heteromeric DNA - binding forms .", "entity": [{"entity": "Ah receptor complex", "entity_type": "GENE", "pos": [23, 42]}], "task": "NER"}
{"text": "KatA , AhpCF , heme biosynthesis enzymes , and MrgA are also induced upon entry into stationary phase under conditions of iron and manganese limitation .", "entity": [{"entity": "KatA", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "AhpCF", "entity_type": "GENE", "pos": [7, 12]}, {"entity": "MrgA", "entity_type": "GENE", "pos": [47, 51]}], "task": "NER"}
{"text": "Characterization of the chromosome 19 breakpoint region revealed that the transcription factor - encoding USF2 gene is affected .", "entity": [{"entity": "transcription factor - encoding USF2 gene", "entity_type": "GENE", "pos": [74, 115]}], "task": "NER"}
{"text": "Analysis of pseudo VH gene segment recombination products reveals no bias in D gene segment reading frame utilization .", "entity": [{"entity": "pseudo VH gene segment recombination products", "entity_type": "GENE", "pos": [12, 57]}, {"entity": "D gene segment", "entity_type": "GENE", "pos": [77, 91]}], "task": "NER"}
{"text": "It is dangerous to label such conditions as ' inappropriate ' secretion of ADH since the maintenance of circulating volume is at least as important a physiological requirement as the defence of tonicity .", "entity": [{"entity": "ADH", "entity_type": "GENE", "pos": [75, 78]}], "task": "NER"}
{"text": "The in vitro activity of KP - 103 , a novel triazole derivative , against pathogenic fungi that cause dermatomycoses and its therapeutic efficacy against plantar tinea pedis and cutaneous candidiasis in guinea pigs were investigated .", "entity": [], "task": "NER"}
{"text": "Using a simulated cough machine , we analyzed the effect of adding tensio - active liquids as sol phase simulant on the clearance of gel mucus simulant by cough .", "entity": [], "task": "NER"}
{"text": "The effects of 4 weeks of cyclosporin A ( 7 mg / kg per day ) ( CyA ) on the survival of vascularized osteochondral grafts between rat strains [ DA ( donor ) and Lewis ( recipient ) ] and the presence and significance of host immune tolerance and graft antigen modulation after cessation of immunosuppression have been examined .", "entity": [], "task": "NER"}
{"text": "Insulin binding to the alpha - subunit of its receptor stimulates the receptor tyrosine kinase to phosphorylate the beta - subunit and several endogenous protein substrates , including pp120 / HA4 , a liver - specific plasma membrane glycoprotein of M ( r ) 20 , 000 .", "entity": [{"entity": "Insulin", "entity_type": "GENE", "pos": [0, 7]}, {"entity": "receptor tyrosine kinase", "entity_type": "GENE", "pos": [70, 94]}, {"entity": "pp120", "entity_type": "GENE", "pos": [185, 190]}, {"entity": "HA4", "entity_type": "GENE", "pos": [193, 196]}], "task": "NER"}
{"text": "The second intron is the smallest of all the introns ( 116 bp ) .", "entity": [], "task": "NER"}
{"text": "Moreover , our recent findings on the Tc52 encoding gene underline the interest of genetic manipulation of T . cruzi , not only making it possible to use more closely an in vitro approach to find out how genes function , but also to obtain ' attenuated ' strains that could be used in the development of vaccinal strategies .", "entity": [{"entity": "Tc52 encoding gene", "entity_type": "GENE", "pos": [38, 56]}], "task": "NER"}
{"text": "Pretreatment of rats with different dose levels of CCl4 resulted in a prolongation of TMO half - life , and increase of the area under the curve ( AUC ) , and a decrease of clearance , but the apparent volume of distribution ( Vd ) was not significantly decreased .", "entity": [], "task": "NER"}
{"text": "Healthy preterm infants of gestational age 26 - 29 weeks showed a ' mature ' pattern of permeability at birth , followed by a temporary period of enhanced permeability after 3 - 4 weeks of life .", "entity": [], "task": "NER"}
{"text": "The promoter for HMG - CoA synthase contains two binding sites for the sterol regulatory element - binding proteins ( SREBPs ) .", "entity": [{"entity": "HMG - CoA synthase", "entity_type": "GENE", "pos": [17, 35]}, {"entity": "sterol regulatory element - binding proteins", "entity_type": "GENE", "pos": [71, 115]}, {"entity": "SREBPs", "entity_type": "GENE", "pos": [118, 124]}], "task": "NER"}
{"text": "Using the same electrical analog , we present an analysis that allows calculation of these parameters , as well as the corner frequency of the network ( f1 ) , without need for similar assumptions .", "entity": [], "task": "NER"}
{"text": "These results suggest that transcription influences aspects of gene conversion after initiation , such as strand invasion and / or mismatch repair ( MMR ) .", "entity": [], "task": "NER"}
{"text": "In contrast , a similar fusion protein ( hGH - LDLR - DAF17 , abbreviated HLD ) containing a fragment of the serine / threonine - rich domain of the LDL receptor ( LDLR ) in place of the DAF - derived serine / threonine - rich sequences , does not become GPI anchored .", "entity": [{"entity": "hGH", "entity_type": "GENE", "pos": [41, 44]}, {"entity": "LDLR", "entity_type": "GENE", "pos": [47, 51]}, {"entity": "DAF17", "entity_type": "GENE", "pos": [54, 59]}, {"entity": "HLD", "entity_type": "GENE", "pos": [74, 77]}, {"entity": "LDL receptor", "entity_type": "GENE", "pos": [149, 161]}, {"entity": "LDLR", "entity_type": "GENE", "pos": [164, 168]}, {"entity": "DAF - derived serine / threonine - rich sequences", "entity_type": "GENE", "pos": [187, 236]}], "task": "NER"}
{"text": "Ocular injuries during general anesthesia .", "entity": [], "task": "NER"}
{"text": "Of concern is the high , unexplained prevalence of BV among African - American women , who are also at extremely high risk for preterm birth .", "entity": [], "task": "NER"}
{"text": "The RAG - 2 gene encodes a component of the V ( D ) J recombinase which is essential for the assembly of antigen receptor genes in B and T lymphocytes .", "entity": [{"entity": "RAG - 2 gene", "entity_type": "GENE", "pos": [4, 16]}, {"entity": "V ( D ) J recombinase", "entity_type": "GENE", "pos": [44, 65]}], "task": "NER"}
{"text": "The LAB in the cecum ( mean 9 . 4 log CFU / g ) increased slightly with increasing abattoir holding time .", "entity": [], "task": "NER"}
{"text": "Reproduction and maternal response of the rat when thiamine intake is limited .", "entity": [], "task": "NER"}
{"text": "Activated Ki - Ras suppresses 12 - O - tetradecanoylphorbol - 13 - acetate - induced activation of the c - Jun NH2 - terminal kinase pathway in human colon cancer cells .", "entity": [{"entity": "Activated Ki - Ras", "entity_type": "GENE", "pos": [0, 18]}, {"entity": "c - Jun NH2 - terminal kinase pathway", "entity_type": "GENE", "pos": [103, 140]}], "task": "NER"}
{"text": "11 : 5801 - 5812 , 1991 ) present evidence that the Vps18 / Pep3 protein colocalizes with the Vps11 / Pep5 protein to the cytosolic face of the vacuolar membrane .", "entity": [{"entity": "Vps18", "entity_type": "GENE", "pos": [52, 57]}, {"entity": "Pep3", "entity_type": "GENE", "pos": [60, 64]}, {"entity": "Vps11", "entity_type": "GENE", "pos": [94, 99]}, {"entity": "Pep5", "entity_type": "GENE", "pos": [102, 106]}], "task": "NER"}
{"text": "Cell - free extracts of E . coli ( fpg mutY ) harboring pYSB10 possess an enzymatic activity that cleaves a 34 - mer oligonucleotide containing a single 8 - oxoG opposite a cytosine ( 8 - OxoG / C ) .", "entity": [{"entity": "fpg", "entity_type": "GENE", "pos": [35, 38]}, {"entity": "mutY", "entity_type": "GENE", "pos": [39, 43]}], "task": "NER"}
{"text": "The authors discussed their experience in investigating 20 patients with maxillary malignant tumors using routine x - ray studies and MR - tomography , and 13 patients , investigated in the same way plus CT .", "entity": [], "task": "NER"}
{"text": "Magnification - corrected planimetry of the parapapillary region was performed according to Littmann ' s method in 312 unselected eyes with chronic primary open - angle glaucoma and in 125 normal eyes of an age - and refraction - matched control group using optic disk photographs .", "entity": [], "task": "NER"}
{"text": "Both merR genes consist of a 408 bp ORF coding for 135 amino acids .", "entity": [{"entity": "merR genes", "entity_type": "GENE", "pos": [5, 15]}], "task": "NER"}
{"text": "The 1 . 3 - kb DNA , when placed upstream of the chloramphenicol acetyltransferase gene , was shown to be functionally active .", "entity": [{"entity": "chloramphenicol acetyltransferase gene", "entity_type": "GENE", "pos": [49, 87]}], "task": "NER"}
{"text": "We show that Fos down regulates several immediate - early genes ( c - fos , Egr - 1 , and Egr - 2 ) after mitogenic stimulation .", "entity": [{"entity": "Fos", "entity_type": "GENE", "pos": [13, 16]}, {"entity": "immediate - early genes", "entity_type": "GENE", "pos": [40, 63]}, {"entity": "c - fos", "entity_type": "GENE", "pos": [66, 73]}, {"entity": "Egr - 1", "entity_type": "GENE", "pos": [76, 83]}, {"entity": "Egr - 2", "entity_type": "GENE", "pos": [90, 97]}], "task": "NER"}
{"text": "Polar effects of transposon insertions demonstrated that all of these mRNAs arose from a single promoter region , where transcription initiated 80 bp 5 ' to nifH .", "entity": [{"entity": "nifH", "entity_type": "GENE", "pos": [157, 161]}], "task": "NER"}
{"text": "Heart disease .", "entity": [], "task": "NER"}
{"text": "A definitive answer to the question must come from large scale mortality studies of patients in whom the risk / benefit ratio of thrombolysis is not unacceptably high , in whom electrocardiographic criteria of infarction are unequivocal , and in whom treatment can be initiated early after the onset of symptoms with regimens that will induce not only early recanalization , but also sustained patency in infarct - related arteries .", "entity": [], "task": "NER"}
{"text": "Sonography depicted the true morphology of these cystic lesions more clearly than CT , and the sonographic findings virtually excluded uncomplicated hepatic cyst as a diagnosis .", "entity": [], "task": "NER"}
{"text": "The formation of tumorlike lesions in the cockroach leucophaea maderae after anal blockage .", "entity": [], "task": "NER"}
{"text": "Here , we identify the analytical form of the PDF of one such measure , the order parameter in the low temperature phase of the 2D XY model .", "entity": [], "task": "NER"}
{"text": "The determination of antithrombin III ( AT III ) and its clinical significance", "entity": [{"entity": "antithrombin III", "entity_type": "GENE", "pos": [21, 37]}, {"entity": "AT III", "entity_type": "GENE", "pos": [40, 46]}], "task": "NER"}
{"text": "In each of the studied HPV types , the two CDP / Cut binding sites of PSM overlap with the known or presumed binding sites of the replication initiator protein E1 .", "entity": [{"entity": "CDP", "entity_type": "GENE", "pos": [43, 46]}, {"entity": "Cut", "entity_type": "GENE", "pos": [49, 52]}, {"entity": "PSM", "entity_type": "GENE", "pos": [70, 73]}, {"entity": "replication initiator protein E1", "entity_type": "GENE", "pos": [130, 162]}], "task": "NER"}
{"text": "With this study , a total of 13 operators for the glp regulon have been characterized .", "entity": [{"entity": "glp regulon", "entity_type": "GENE", "pos": [50, 61]}], "task": "NER"}
{"text": "Located between the 3 ' trans - spliced leader acceptor site and the translational initiation codon of the GP63 gene is an area of conserved hexanucleotide direct repeats ( CTCGCC ) which vary in number according to species .", "entity": [{"entity": "GP63 gene", "entity_type": "GENE", "pos": [107, 116]}], "task": "NER"}
{"text": "The aim of this study was to evaluate the impact of the ESRD treatment modality on the quality of life in patients with Type I ( insulin - dependent ) diabetes mellitus .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [129, 136]}], "task": "NER"}
{"text": "MDA - MB - 468 cells were stably transfected with either a plasmid having a CMV promoter - driven rabbit beta - globin gene or plasmids having a CMV promoter - driven chimeric gadd45 5 \" - UTR - rabbit beta - globin gene , where the entire gadd45 5 \" - UTR ( from + 1 to + 298 ) or a 45 bp subfragment of the gadd45 5 \" - UTR ( from + 10 to + 55 ) was positioned at the 5 \" - end of the rabbit beta - globin gene .", "entity": [{"entity": "CMV promoter", "entity_type": "GENE", "pos": [76, 88]}, {"entity": "rabbit beta - globin gene", "entity_type": "GENE", "pos": [98, 123]}, {"entity": "CMV promoter", "entity_type": "GENE", "pos": [145, 157]}, {"entity": "gadd45", "entity_type": "GENE", "pos": [176, 182]}, {"entity": "rabbit beta - globin", "entity_type": "GENE", "pos": [195, 215]}, {"entity": "entire gadd45 5 \" - UTR ( from + 1 to + 298 )", "entity_type": "GENE", "pos": [233, 278]}, {"entity": "gadd45 5 \" - UTR ( from + 10 to + 55 )", "entity_type": "GENE", "pos": [309, 347]}, {"entity": "rabbit beta - globin gene", "entity_type": "GENE", "pos": [387, 412]}], "task": "NER"}
{"text": "RESULTS : BMK - 1 and other 19 contents significantly decreased depolarization parameters Vmax , APA , OS , and MDP , which was similar to that of TTX and different from that of Nim and BaCl2 .", "entity": [{"entity": "BMK - 1", "entity_type": "GENE", "pos": [10, 17]}, {"entity": "TTX", "entity_type": "GENE", "pos": [147, 150]}], "task": "NER"}
{"text": "Fourteen samples , seven each of IR64 and IR66 were studied with regard to moisture content , germination test , abnormal seedlings , speed of germination , conductance of leachates , total dehydrogenase activity , total free amino acids , total soluble sugar , fat acidity , gelatinization temperature , gel consistency , amylose content , translucency , and per cent whiteness .", "entity": [], "task": "NER"}
{"text": "Southern zoo blot analysis indicated that ZNF236 is conserved in the genomes of all mammalian species tested , but not in yeast .", "entity": [{"entity": "ZNF236", "entity_type": "GENE", "pos": [42, 48]}], "task": "NER"}
{"text": "This alternative splice acceptor site is also used by a biologically active provirus with an efficiency of approximately 5 % compared with the upstream site .", "entity": [], "task": "NER"}
{"text": "In addition to loss of digit identity and varying degrees of polydactyly , proximal skeletal elements are severely shortened in Xt ; ld double homozygous limbs .", "entity": [{"entity": "Xt", "entity_type": "GENE", "pos": [128, 130]}, {"entity": "ld", "entity_type": "GENE", "pos": [133, 135]}], "task": "NER"}
{"text": "In turn , production of sufficient amounts of TraR apparently is sensitive to a cellular function requiring RNase D .", "entity": [{"entity": "TraR", "entity_type": "GENE", "pos": [46, 50]}, {"entity": "RNase D", "entity_type": "GENE", "pos": [108, 115]}], "task": "NER"}
{"text": "In this study , the effect of the antibiotic lasalocid on the rumen anaerobic fungus Neocallimastix frontalis RK 21 was examined .", "entity": [], "task": "NER"}
{"text": "4 382 new mothers were examined retrospectively with the enzyme - linked immunosorbent assay ( ELISA ) for IgG activity to cytomegalovirus ( CMV ) during pregnancy .", "entity": [{"entity": "IgG", "entity_type": "GENE", "pos": [107, 110]}], "task": "NER"}
{"text": "Promoter , spliced leader , and coding sequence for BICP4 , the largest of the immediate - early proteins of bovine herpesvirus 1 .", "entity": [{"entity": "BICP4", "entity_type": "GENE", "pos": [52, 57]}, {"entity": "immediate - early proteins of bovine herpesvirus 1", "entity_type": "GENE", "pos": [79, 129]}], "task": "NER"}
{"text": "ER beta was less potent than ER alpha in activating E2 - stimulated ERELuc activity ( 4 - vs .", "entity": [{"entity": "ER beta", "entity_type": "GENE", "pos": [0, 7]}, {"entity": "ER alpha", "entity_type": "GENE", "pos": [29, 37]}, {"entity": "ERELuc", "entity_type": "GENE", "pos": [68, 74]}], "task": "NER"}
{"text": "Our results suggest a dose - dependent activity of lysine vasopressin on the EEG , which might be similar to that observed in animal and man after administration of nicotine .", "entity": [{"entity": "lysine vasopressin", "entity_type": "GENE", "pos": [51, 69]}], "task": "NER"}
{"text": "However , elimination of the kinase activity of DCAMKL1 has no detectable effect on its microtubule polymerization activity .", "entity": [{"entity": "DCAMKL1", "entity_type": "GENE", "pos": [48, 55]}], "task": "NER"}
{"text": "Sequencing and restriction enzyme analysis demonstrated that this single - copy gene contains 11 exons and spans 9596 base pairs .", "entity": [], "task": "NER"}
{"text": "Effects of prolonged inhibition of labour pains with Th 1165a and Isoptin on the heart , circulation , organ - and metabolic parameters of the mother", "entity": [], "task": "NER"}
{"text": "The anaesthetic management of 41 patients who underwent cardiac transplantation during a 40 month period at Clinica Puerta de Hierro is reviewed .", "entity": [], "task": "NER"}
{"text": "In uraemic patients , similar maximum serum concentrations were found after a single 7 . 5 mg / kg iv dose .", "entity": [], "task": "NER"}
{"text": "In the unit housing of a compact cyclotron and positron emission CT ( PET ) , positron emitting gas such as 15O , 11C , C15O2 , C15O etc . is supplied from a cyclotron to a PET room through a transportation pipe with an appropriate shield to reduce positron annihilation radiation .", "entity": [], "task": "NER"}
{"text": "Although CB - 4 isolates were less resistant to chlorine than CB - 5 isolates , after 1 , 000 min of contact 0 . 01 % of the input virus was still infectious .", "entity": [], "task": "NER"}
{"text": "Here we describe the cloning and initial characterization of IPP , a novel human gene that predicts a kelch family protein homologous to the mouse Ipp gene , a previously described kelch family member .", "entity": [{"entity": "IPP", "entity_type": "GENE", "pos": [61, 64]}, {"entity": "kelch family protein", "entity_type": "GENE", "pos": [102, 122]}, {"entity": "mouse Ipp gene", "entity_type": "GENE", "pos": [141, 155]}, {"entity": "kelch family member", "entity_type": "GENE", "pos": [181, 200]}], "task": "NER"}
{"text": "Sequence analysis identifies a ras - associating ( RA ) - like domain in the N - termini of band 4 . 1 / JEF domains and in the Grb7 / 10 / 14 adapter family .", "entity": [{"entity": "ras - associating", "entity_type": "GENE", "pos": [31, 48]}, {"entity": "RA", "entity_type": "GENE", "pos": [51, 53]}, {"entity": "band 4 . 1 / JEF domains", "entity_type": "GENE", "pos": [92, 116]}, {"entity": "Grb7 / 10 / 14 adapter family", "entity_type": "GENE", "pos": [128, 157]}], "task": "NER"}
{"text": "Sleeping position and sudden infant death syndrome ( SIDS ) : effect of an intervention programme to avoid prone sleeping .", "entity": [], "task": "NER"}
{"text": "Statistical conservation laws in turbulent transport .", "entity": [], "task": "NER"}
{"text": "Characterization and targeted disruption of murine Nup50 , a p27 ( Kip1 ) - interacting component of the nuclear pore complex . p27 ( Kip1 ) is a member of the Cip - Kip family of cyclin - dependent kinase ( Cdk ) inhibitors that binds to cyclin - Cdk complexes and inhibits their catalytic activity in response to antiproliferative stimuli . p27 ( Kip1 ) is regulated by several posttranscriptional mechanisms , including subcellular localization .", "entity": [{"entity": "murine Nup50", "entity_type": "GENE", "pos": [44, 56]}, {"entity": "p27", "entity_type": "GENE", "pos": [61, 64]}, {"entity": "Kip1", "entity_type": "GENE", "pos": [67, 71]}, {"entity": "p27", "entity_type": "GENE", "pos": [128, 131]}, {"entity": "Kip1", "entity_type": "GENE", "pos": [134, 138]}, {"entity": "Cip", "entity_type": "GENE", "pos": [160, 163]}, {"entity": "Kip", "entity_type": "GENE", "pos": [166, 169]}, {"entity": "cyclin - dependent kinase", "entity_type": "GENE", "pos": [180, 205]}, {"entity": "Cdk", "entity_type": "GENE", "pos": [208, 211]}, {"entity": "cyclin", "entity_type": "GENE", "pos": [239, 245]}, {"entity": "Cdk", "entity_type": "GENE", "pos": [248, 251]}, {"entity": "p27", "entity_type": "GENE", "pos": [343, 346]}, {"entity": "Kip1", "entity_type": "GENE", "pos": [349, 353]}], "task": "NER"}
{"text": "Further studies are warranted to determine whether these findings are idiosyncratic , coincidental , or a more general phenomenon .", "entity": [], "task": "NER"}
{"text": "We have identified the gene encoding sigma E using a genetic screen designed to isolate trans - acting mutations that abolish expression from either htrA or rpoHP3 , two promoters recognized uniquely by sigma E - containing RNA polymerase .", "entity": [{"entity": "sigma E", "entity_type": "GENE", "pos": [37, 44]}, {"entity": "htrA", "entity_type": "GENE", "pos": [149, 153]}, {"entity": "rpoHP3", "entity_type": "GENE", "pos": [157, 163]}, {"entity": "sigma E", "entity_type": "GENE", "pos": [203, 210]}, {"entity": "RNA polymerase", "entity_type": "GENE", "pos": [224, 238]}], "task": "NER"}
{"text": "METHODOLOGY : A case control study of survivors with gestational age ( GA ) < 28 weeks or birthweight ( BW ) < 1000 g using data collected prospectively in our Neonatal Intensive Care Unit database .", "entity": [], "task": "NER"}
{"text": "Based on these results , it has been concluded that an IPFSA can promote the healing process in the avascular zone of a torn meniscus in rabbits and that systemic vascularity to the synovium or the meniscus is not essential for healing to occur .", "entity": [], "task": "NER"}
{"text": "Biomass growth monitoring using pressure drop in a cocurrent biofilter", "entity": [], "task": "NER"}
{"text": "Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells : a comparison of the \" hot spot \" mutant phenotypes .", "entity": [{"entity": "p53 DNA", "entity_type": "GENE", "pos": [7, 14]}, {"entity": "ras", "entity_type": "GENE", "pos": [65, 68]}], "task": "NER"}
{"text": "The RHO1 gene encodes a homolog of the mammalian RhoA small GTP - binding protein in the yeast Saccharomyces cerevisiae .", "entity": [{"entity": "RHO1 gene", "entity_type": "GENE", "pos": [4, 13]}, {"entity": "RhoA small GTP - binding protein", "entity_type": "GENE", "pos": [49, 81]}], "task": "NER"}
{"text": "Inspection of X . tropicalis , mouse and human U6 DNA upstream sequences revealed the presence of a TATA box as well as of the proximal and enhancer ( octamer motif ) elements contained in snRNA genes transcribed by RNA polymerase II .", "entity": [{"entity": "X . tropicalis , mouse and human U6 DNA upstream sequences", "entity_type": "GENE", "pos": [14, 72]}, {"entity": "RNA polymerase II", "entity_type": "GENE", "pos": [216, 233]}], "task": "NER"}
{"text": "RESULTS : In men , weight / height2 met the criteria for a satisfactory index in that there was a very strong correlation with triceps skinfold , and a negligible correlation with height .", "entity": [], "task": "NER"}
{"text": "When expressed in thymidine kinase - deficient L cells or 3T3 cells , C / EBPalpha is detected in a protein complex which binds to the E2F binding sites found in the promoters of the genes for E2F - 1 and dihydrofolate reductase ( DHFR ) .", "entity": [{"entity": "thymidine kinase", "entity_type": "GENE", "pos": [18, 34]}, {"entity": "C / EBPalpha", "entity_type": "GENE", "pos": [70, 82]}, {"entity": "E2F binding sites", "entity_type": "GENE", "pos": [135, 152]}, {"entity": "E2F - 1", "entity_type": "GENE", "pos": [193, 200]}, {"entity": "dihydrofolate reductase", "entity_type": "GENE", "pos": [205, 228]}, {"entity": "DHFR", "entity_type": "GENE", "pos": [231, 235]}], "task": "NER"}
{"text": "Phenylalanine and tyrosine levels were higher in those who received Vamin 9 glucose but 55 % of infants given Vamin Infant had tyrosine levels below the lower limit of the target range .", "entity": [], "task": "NER"}
{"text": "Identification of an osteocalcin gene promoter sequence that binds AP1 .", "entity": [{"entity": "osteocalcin gene promoter sequence", "entity_type": "GENE", "pos": [21, 55]}, {"entity": "AP1", "entity_type": "GENE", "pos": [67, 70]}], "task": "NER"}
{"text": "CONCLUSIONS : Neurodevelopmental assessment at 1 year is predictive of school performance and outcome in the adolescent period .", "entity": [], "task": "NER"}
{"text": "Phenotypic responses of additional mutants , including exo1 , srs2 , rad5 , and rdh54 strains , suggest roles in recombinational repair , but not in NHEJ .", "entity": [{"entity": "exo1", "entity_type": "GENE", "pos": [55, 59]}, {"entity": "srs2", "entity_type": "GENE", "pos": [62, 66]}, {"entity": "rad5", "entity_type": "GENE", "pos": [69, 73]}, {"entity": "rdh54", "entity_type": "GENE", "pos": [80, 85]}], "task": "NER"}
{"text": "Although hSSTR5 displays approximately 75 % sequence identity with rat SSTR5 , the two receptors display significantly different pharmacological profiles , especially with respect to their binding affinities for the SST analogue SMS 201 - 995 .", "entity": [{"entity": "hSSTR5", "entity_type": "GENE", "pos": [9, 15]}, {"entity": "rat SSTR5", "entity_type": "GENE", "pos": [67, 76]}, {"entity": "SST", "entity_type": "GENE", "pos": [216, 219]}], "task": "NER"}
{"text": "These findings suggest that IL - 1 - stimulated , Rho - dependent cytoskeletal reorganization may cluster signaling molecules in specific architectures that are necessary for persistent cell activation in chronic inflammatory disease .", "entity": [{"entity": "IL - 1", "entity_type": "GENE", "pos": [28, 34]}, {"entity": "Rho", "entity_type": "GENE", "pos": [50, 53]}], "task": "NER"}
{"text": "Deletion mutants of the human CHOP promoter identify a region comprising nucleotides - 75 to - 104 required for both constitutive and ER - stress - inducible expression .", "entity": [{"entity": "human CHOP promoter", "entity_type": "GENE", "pos": [24, 43]}], "task": "NER"}
{"text": "Anderson Hospital and Tumor Institute at Houston during a 30 - year interval ( 1944 to 1974 ) , with a minimum of ten years of follow - up , we determined that the major prognostic factor of survival was the number of positive nodes .", "entity": [], "task": "NER"}
{"text": "It is concluded that the atherogenic process includes stimulation of collagen and elastin synthesis .", "entity": [{"entity": "collagen", "entity_type": "GENE", "pos": [69, 77]}, {"entity": "elastin", "entity_type": "GENE", "pos": [82, 89]}], "task": "NER"}
{"text": "We report nine consecutive cases of ACB , which occurred in five males and four females and were detected in 11 , 159 routine spiral CT examinations of the chest , performed between 1994 and 1998 .", "entity": [], "task": "NER"}
{"text": "The absolute CD4 count of patients with de novo IBD was 210 - 700 cells / ml at the time of IBD .", "entity": [{"entity": "CD4", "entity_type": "GENE", "pos": [13, 16]}], "task": "NER"}
{"text": "Four of these fibroblast clones were infected with a retrovirus containing the cDNA encoding myoD and a puromycin selection marker .", "entity": [{"entity": "cDNA encoding myoD", "entity_type": "GENE", "pos": [79, 97]}], "task": "NER"}
{"text": "Sexual adventurism , high - risk behavior , and human immunodeficiency virus - 1 seroconversion among the Chicago MACS - CCS cohort , 1984 to 1992 .", "entity": [], "task": "NER"}
{"text": "As already available for the other known mammalian members of this enzyme family , we here define structural and functional features of human lymphoma proprotein convertase ( LPC ) .", "entity": [{"entity": "human lymphoma proprotein convertase", "entity_type": "GENE", "pos": [136, 172]}, {"entity": "LPC", "entity_type": "GENE", "pos": [175, 178]}], "task": "NER"}
{"text": "This study demonstrates the feasibility and potential usefulness of syngeneic BM Txp in myeloma .", "entity": [], "task": "NER"}
{"text": "It is important to understand the etiology of HITT because of its devastating clinical consequences .", "entity": [], "task": "NER"}
{"text": "Results obtained from the tritium test and direct chemical analysis were compared .", "entity": [], "task": "NER"}
{"text": "Relation between clinical and roentgenological scores and measures of lung function in cystic fibrosis , with special reference to pulmonary Xenon133 elimination .", "entity": [], "task": "NER"}
{"text": "Phytohemagglutinin ( PHA ) , the seed lectin of the common bean , accumulates in protein storage vacuoles of storage parenchyma cells in cotyledons .", "entity": [{"entity": "Phytohemagglutinin", "entity_type": "GENE", "pos": [0, 18]}, {"entity": "PHA", "entity_type": "GENE", "pos": [21, 24]}, {"entity": "seed lectin", "entity_type": "GENE", "pos": [33, 44]}], "task": "NER"}
{"text": "New concepts of condyloma acuminata in children .", "entity": [], "task": "NER"}
{"text": "When recombinant gE produced in HeLa cells was probed with the same antiphosphotyrosine antibody , a dimeric gE form at 130 kDa was detected on the cell surface .", "entity": [{"entity": "recombinant gE", "entity_type": "GENE", "pos": [5, 19]}, {"entity": "dimeric gE", "entity_type": "GENE", "pos": [101, 111]}], "task": "NER"}
{"text": "The levels of soluble L - selectin and ICAM - 1 in the serum were determined by the ELISA method .", "entity": [{"entity": "L - selectin", "entity_type": "GENE", "pos": [22, 34]}, {"entity": "ICAM - 1", "entity_type": "GENE", "pos": [39, 47]}], "task": "NER"}
{"text": "The effect of lung edema on pulmonary vasoactivity of furosemide .", "entity": [], "task": "NER"}
{"text": "Within the last few years , the WWW has grown enormously .", "entity": [], "task": "NER"}
{"text": "Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes : evidence for separate mitochondrial and nuclear functions .", "entity": [{"entity": "Saccharomyces cerevisiae MSH1", "entity_type": "GENE", "pos": [47, 76]}, {"entity": "MSH2 genes", "entity_type": "GENE", "pos": [81, 91]}], "task": "NER"}
{"text": "These cells also showed an increase in cyclin A and cyclin A - and E - associated kinase activities characteristic of S phase induction .", "entity": [{"entity": "cyclin A", "entity_type": "GENE", "pos": [39, 47]}, {"entity": "cyclin A - and E - associated kinase", "entity_type": "GENE", "pos": [52, 88]}], "task": "NER"}
{"text": "Anisotropy of Hc2 and the breadth of the resistive transition of polycrystalline YBa2Cu", "entity": [], "task": "NER"}
{"text": "TGF - beta1 induced phosphorylation of Smad2 and Smad3 in Mv1Lu mink lung epithelial cells .", "entity": [{"entity": "TGF - beta1", "entity_type": "GENE", "pos": [0, 11]}, {"entity": "Smad2", "entity_type": "GENE", "pos": [39, 44]}, {"entity": "Smad3", "entity_type": "GENE", "pos": [49, 54]}], "task": "NER"}
{"text": "Changes in the frequency of X - chromatin in women under Prednisone therapy", "entity": [], "task": "NER"}
{"text": "Obtaining kidney cells from a beagle puppy ( RPB - 1 ) and the establishment of a cryopreservation bank", "entity": [], "task": "NER"}
{"text": "Microscopically , cartilage showed markedly stunted and disorganized endochondral ossification .", "entity": [], "task": "NER"}
{"text": "When incubated with infective larvae which had penetrated mouse skin , both normal and immune cells attached to larvae in the absence of serum .", "entity": [], "task": "NER"}
{"text": "During each step of the pulse infusion the osteocalcin responses to changes in CaI in general were parallel to the changes in PTH ( r = 0 . 462 ; P = 0 . 02 ) and were inversely correlated to CaI ( r = - 0 . 562 ; P = 0 . 003 ) .", "entity": [{"entity": "osteocalcin", "entity_type": "GENE", "pos": [43, 54]}, {"entity": "PTH", "entity_type": "GENE", "pos": [126, 129]}], "task": "NER"}
{"text": "GH signals by interacting with GH receptor ( GHR ) .", "entity": [{"entity": "GH", "entity_type": "GENE", "pos": [0, 2]}, {"entity": "GH receptor", "entity_type": "GENE", "pos": [31, 42]}, {"entity": "GHR", "entity_type": "GENE", "pos": [45, 48]}], "task": "NER"}
{"text": "These data suggest that overexpression of MT potentiates the growth of MCF7 cells , whereas downregulation of MT elicits antiproliferative effects .", "entity": [{"entity": "MT", "entity_type": "GENE", "pos": [42, 44]}, {"entity": "MT", "entity_type": "GENE", "pos": [110, 112]}], "task": "NER"}
{"text": "The induction by dexamethasone of rat liver CYP3A1 differs from classical glucocorticoid gene regulation in part because both glucocorticoids and antiglucocorticoids such as pregnenolone 16 alpha - carbonitrile ( PCN ) induce CYP3A1 through transcriptional gene activation .", "entity": [{"entity": "rat liver CYP3A1", "entity_type": "GENE", "pos": [34, 50]}, {"entity": "CYP3A1", "entity_type": "GENE", "pos": [226, 232]}], "task": "NER"}
{"text": "A pharmacokinetic interaction between LY354740 and diazepam , leading to the lowering of the plasma level of free diazepam , was also demonstrated .", "entity": [], "task": "NER"}
{"text": "Also , in patients with MYD , there was a significant decrease in arterial PO2 from the seated posture to the supine posture , without a significant change in the arterial PCO2 .", "entity": [], "task": "NER"}
{"text": "The animals were followed over a 1 - to 6 - h posttraumatic course , and processed for the LM and TEM visualization of HRP .", "entity": [{"entity": "HRP", "entity_type": "GENE", "pos": [119, 122]}], "task": "NER"}
{"text": "Glucose consumption of the human brain under the influence of intravenous infusions of glucose , glucagon and glucose - insulin", "entity": [{"entity": "glucagon", "entity_type": "GENE", "pos": [97, 105]}], "task": "NER"}
{"text": "The signs of enterocolitis , pathological microbial flora in the stool and changes in the colon mucosa were absent .", "entity": [], "task": "NER"}
{"text": "This study was undertaken to evaluate the physical and biological characteristics of nebulized interleukin 2 liposomes .", "entity": [{"entity": "interleukin 2", "entity_type": "GENE", "pos": [95, 108]}], "task": "NER"}
{"text": "Although mutant pex5delta cells expressing a yeast / tobacco Pex5p chimaera failed to import a GFP - Eci1p reporter protein , they were able to grow on oleic acid .", "entity": [{"entity": "mutant pex5delta", "entity_type": "GENE", "pos": [9, 25]}, {"entity": "yeast / tobacco Pex5p chimaera", "entity_type": "GENE", "pos": [45, 75]}, {"entity": "GFP", "entity_type": "GENE", "pos": [95, 98]}, {"entity": "Eci1p", "entity_type": "GENE", "pos": [101, 106]}], "task": "NER"}
{"text": "Two human beta - 1 , 6 - N - acetylglucosaminyltransferases forming the core 2 O - glycan branch , C2GnT and the I antigen , IGnT , are homologous to each other in three regions of the catalytic domain ( A , B , C ) and their genes reside at the same locus , chromosome 9 , band q21 ( Bierhuizen , M . F . A . , Mattei , M . - G . and Fukuda , M . , Genes Dev . , 7 , 468 - 478 , 1993 ) .", "entity": [{"entity": "human beta - 1 , 6 - N - acetylglucosaminyltransferases", "entity_type": "GENE", "pos": [4, 59]}, {"entity": "I antigen", "entity_type": "GENE", "pos": [113, 122]}, {"entity": "IGnT", "entity_type": "GENE", "pos": [125, 129]}], "task": "NER"}
{"text": "Previously , we had shown that interleukin 8 ( IL - 8 ) is constitutively expressed in HTLV - I - infected cells and in cells transiently expressing Tax .", "entity": [{"entity": "interleukin 8", "entity_type": "GENE", "pos": [31, 44]}, {"entity": "IL - 8", "entity_type": "GENE", "pos": [47, 53]}, {"entity": "Tax", "entity_type": "GENE", "pos": [149, 152]}], "task": "NER"}
{"text": "We undertook this study to examine the relationship between systemic oxygen delivery ( DO2 ) and tissue oxygen tension ( TPO2 ) in hypovolemic shock .", "entity": [], "task": "NER"}
{"text": "The lowest PaCO2 values were significantly lower in MCE than in the F , W , and D ( F + W + D ) group or controls .", "entity": [], "task": "NER"}
{"text": "The psychosomatic approach to temporomandibular arthrosis", "entity": [], "task": "NER"}
{"text": "Detection of sinusoidal gratings by pattern - specific detectors : further evidence for the correlation principle in human vision .", "entity": [], "task": "NER"}
{"text": "The transcriptional start site ( s ) of the IA - 2 gene was mapped by 5 ' rapid amplification of cDNA ends to 97 bp upstream of the translational start site .", "entity": [{"entity": "IA - 2 gene", "entity_type": "GENE", "pos": [44, 55]}], "task": "NER"}
{"text": "Function was retained when one copy of the sequence was present , suggesting that this sequence represents an essential element .", "entity": [], "task": "NER"}
{"text": "The data also suggest that gamma CACCC box binding factors mediate LCR - gamma interactions which normally enhance gamma - globin and suppress beta - globin gene expression in fetal erythroid cells .", "entity": [{"entity": "gamma CACCC box binding factors", "entity_type": "GENE", "pos": [27, 58]}, {"entity": "LCR - gamma", "entity_type": "GENE", "pos": [67, 78]}, {"entity": "gamma - globin", "entity_type": "GENE", "pos": [115, 129]}, {"entity": "beta - globin gene", "entity_type": "GENE", "pos": [143, 161]}], "task": "NER"}
{"text": "Left ventricle to coronary sinus fistula .", "entity": [], "task": "NER"}
{"text": "No other transcripts of different length could be detected after prolonged exposure .", "entity": [], "task": "NER"}
{"text": "We have isolated and sequenced cDNA sequences corresponding to two novel genes that map to Xq28 .", "entity": [], "task": "NER"}
{"text": "The vaccinia virus D6R open reading frame encodes the small subunit of the heterodimeric vaccinia virus early transcription factor ( VETF ) that activates transcription of early genes in vitro .", "entity": [{"entity": "D6R", "entity_type": "GENE", "pos": [19, 22]}, {"entity": "vaccinia virus early transcription factor", "entity_type": "GENE", "pos": [89, 130]}, {"entity": "VETF", "entity_type": "GENE", "pos": [133, 137]}, {"entity": "early genes", "entity_type": "GENE", "pos": [172, 183]}], "task": "NER"}
{"text": "We have used nuclear magnetic resonance ( NMR ) to obtain the structure of an RNA \" kissing \" hairpin complex formed between the HIV - 2 TAR hairpin loop and a hairpin with a complementary loop sequence .", "entity": [], "task": "NER"}
{"text": "Xnr3 is transcriptionally activated by wnt signaling during gastrulation in the Xenopus embryo .", "entity": [{"entity": "Xnr3", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "wnt", "entity_type": "GENE", "pos": [39, 42]}], "task": "NER"}
{"text": "In this report , we identify Tyr319 as a functionally important phosphorylation site in the ZAP - 70 interdomain B region .", "entity": [{"entity": "ZAP - 70 interdomain B region", "entity_type": "GENE", "pos": [92, 121]}], "task": "NER"}
{"text": "Renal dysplasia with multisystem malformation - - a study of 9 cases .", "entity": [], "task": "NER"}
{"text": "Brome mosaic virus polymerase - like protein 2a is directed to the endoplasmic reticulum by helicase - like viral protein 1a .", "entity": [{"entity": "Brome mosaic virus polymerase", "entity_type": "GENE", "pos": [0, 29]}, {"entity": "protein 2a", "entity_type": "GENE", "pos": [37, 47]}, {"entity": "helicase", "entity_type": "GENE", "pos": [92, 100]}, {"entity": "viral protein 1a", "entity_type": "GENE", "pos": [108, 124]}], "task": "NER"}
{"text": "Mutations abolishing MalK function not only result in inability to transport maltose but also cause constitutive expression of the maltose regulon .", "entity": [{"entity": "MalK", "entity_type": "GENE", "pos": [21, 25]}, {"entity": "maltose regulon", "entity_type": "GENE", "pos": [131, 146]}], "task": "NER"}
{"text": "The D . discoideum proteins were entirely conserved over the four regions known to be important for GTP binding and all contained the C - terminal CAAX aa motifs shared by other Rho proteins .", "entity": [{"entity": "Rho proteins", "entity_type": "GENE", "pos": [178, 190]}], "task": "NER"}
{"text": "The lack of chronically depressed LCBF ( after 1 day ) may be related to the quick structural repair of endothelium .", "entity": [], "task": "NER"}
{"text": "Functional uncoupling of the Janus kinase 3 - Stat5 pathway in malignant growth of human T cell leukemia virus type 1 - transformed human T cells .", "entity": [{"entity": "Janus kinase 3", "entity_type": "GENE", "pos": [29, 43]}, {"entity": "Stat5", "entity_type": "GENE", "pos": [46, 51]}], "task": "NER"}
{"text": "An environmental investigation found evidence of suboptimal food storage and cooking temperatures at Restaurant A ; cross contamination of foods may have contributed to the low attributable risk identified for chile rellenos .", "entity": [], "task": "NER"}
{"text": "We used event - related functional magnetic resonance imaging ( fMRI ) during a cued spatial - attention task to dissociate brain activity related to attentional control from that related to selective processing of target stimuli .", "entity": [], "task": "NER"}
{"text": "However , microinjection of reconstituted mRNPs into Xenopus oocytes demonstrates that although translational repression occurs in the absence of consensus RNA binding sequences for FRGY2 , the presence of FRGY2 recognition elements within mRNA potentiates translational repression .", "entity": [{"entity": "FRGY2", "entity_type": "GENE", "pos": [182, 187]}, {"entity": "FRGY2 recognition elements", "entity_type": "GENE", "pos": [206, 232]}], "task": "NER"}
{"text": "Results of the study suggest that Chinese medicine use among this population depends on health conditions , and that having a regular source of care for Chinese medicine as well as a preference for Chinese medicine are two predictors for its use .", "entity": [], "task": "NER"}
{"text": "A V1 mutant generated in vivo with 11 of the 14 N - terminal amino acids altered , was viable and produced symptoms typical of a wild - type infection .", "entity": [{"entity": "V1 mutant", "entity_type": "GENE", "pos": [2, 11]}], "task": "NER"}
{"text": "These observations suggest that clr4 + and rik1 + must play a role in the assembly of Swi6p into a transcriptionally silent , inaccessible chromatin structure at fission yeast centromeres which is required to facilitate interactions with spindle microtubules and to ensure normal chromosome segregation .", "entity": [{"entity": "clr4 +", "entity_type": "GENE", "pos": [32, 38]}, {"entity": "rik1 +", "entity_type": "GENE", "pos": [43, 49]}, {"entity": "Swi6p", "entity_type": "GENE", "pos": [86, 91]}], "task": "NER"}
{"text": "The gene sequence predicts a 150 , 825 mol wt apoprotein of 1363 amino acids having an N - terminal hydrophobic signal sequence of 17 amino acids , 19 potential N - linked glycosylation sites , a hydrophobic anchor sequence of approximately 17 amino acids near the C terminus , and a hydrophilic cysteine - rich C terminus of 35 amino acids .", "entity": [], "task": "NER"}
{"text": "Likewise , epidural morphine does not modify the intraoperative metabolic and hormonal responses .", "entity": [], "task": "NER"}
{"text": "Only the native structure of phosphorylated ERK was recognized by VHR and was inactivated with a second - order rate constant of 40 , 000 M - 1 s - 1 .", "entity": [{"entity": "ERK", "entity_type": "GENE", "pos": [44, 47]}, {"entity": "VHR", "entity_type": "GENE", "pos": [66, 69]}], "task": "NER"}
{"text": "Omitting part of the experimental NOE - derived distances results in reduced restraint violations and lower R factors but impairs structural convergence in the rMD refinement .", "entity": [], "task": "NER"}
{"text": "The region immediately following the promoter and 5 ' to ORF1 has a potential transcription terminator sequence .", "entity": [], "task": "NER"}
{"text": "Cell cycle regulatory components have been largely conserved in eukaryotes ; however , orthologs of neither CAK1 nor csk1 have been identified in other species to date .", "entity": [{"entity": "CAK1", "entity_type": "GENE", "pos": [108, 112]}, {"entity": "csk1", "entity_type": "GENE", "pos": [117, 121]}], "task": "NER"}
{"text": "Within any cell line , several Tcfs and TLEs are co - expressed .", "entity": [{"entity": "Tcfs", "entity_type": "GENE", "pos": [31, 35]}, {"entity": "TLEs", "entity_type": "GENE", "pos": [40, 44]}], "task": "NER"}
{"text": "In marked contrast to the previously published human CD6 sequence , the mouse sequence predicts a long cytoplasmic tail that is not closely related to other proteins and possesses two proline - rich motifs containing the SH3 - domain binding consensus sequence , three protein kinase C phosphorylation site motifs , nine casein kinase - 2 phosphorylation site motifs , and a serine - threonine - rich motif repeated three times .", "entity": [{"entity": "human CD6 sequence", "entity_type": "GENE", "pos": [47, 65]}, {"entity": "SH3 - domain binding consensus sequence", "entity_type": "GENE", "pos": [221, 260]}, {"entity": "protein kinase C phosphorylation site motifs", "entity_type": "GENE", "pos": [269, 313]}, {"entity": "casein kinase - 2 phosphorylation site motifs", "entity_type": "GENE", "pos": [321, 366]}], "task": "NER"}
{"text": "The Xenopus homeobox gene twin mediates Wnt induction of goosecoid in establishment of Spemann ' s organizer .", "entity": [{"entity": "Xenopus homeobox gene twin", "entity_type": "GENE", "pos": [4, 30]}, {"entity": "Wnt", "entity_type": "GENE", "pos": [40, 43]}, {"entity": "goosecoid", "entity_type": "GENE", "pos": [57, 66]}], "task": "NER"}
{"text": "Quinethazone", "entity": [], "task": "NER"}
{"text": "Divergent regions of the posterior left hemisphere used for decoding and storage of information emerged in each working memory versus control task comparison .", "entity": [], "task": "NER"}
{"text": "Among the different epithelial cell lines tested , only RTS3b cells allowed an expression pattern similar to that observed in naturally infected benign condylomas .", "entity": [], "task": "NER"}
{"text": "These involve ( 1 ) subcloning a promoterless sucCD fragment downstream of the lac promoter in M13mp10 , and ( 2 ) precise splicing of the suc coding regions with the efficient atpE ribosome - binding site and expression from the thermoinducible lambda promoters in the pJLA503 vector .", "entity": [{"entity": "sucCD fragment", "entity_type": "GENE", "pos": [46, 60]}, {"entity": "lac promoter", "entity_type": "GENE", "pos": [79, 91]}, {"entity": "suc coding regions", "entity_type": "GENE", "pos": [139, 157]}, {"entity": "atpE ribosome - binding site", "entity_type": "GENE", "pos": [177, 205]}], "task": "NER"}
{"text": "Increase in [ Ca + + ] counteracted the effects of verapamil on RAD .", "entity": [], "task": "NER"}
{"text": "Evidence for involvement of proteins HU and RpoS in transcription of the osmoresponsive proU operon in Escherichia coli .", "entity": [{"entity": "HU", "entity_type": "GENE", "pos": [37, 39]}, {"entity": "RpoS", "entity_type": "GENE", "pos": [44, 48]}, {"entity": "proU operon", "entity_type": "GENE", "pos": [88, 99]}], "task": "NER"}
{"text": "In comparison to a silent baseline , CBF increases were observed in auditory cortex bilaterally and in the right superior parietal , right dorsolateral frontal , and right premotor regions , with no modulation as a function of attentional condition .", "entity": [], "task": "NER"}
{"text": "Detonation - traumatic load during military service", "entity": [], "task": "NER"}
{"text": "Deletion of CDC5 was lethal and resulted in a dumbbell - shaped terminal morphology , with the nuclei almost divided but still connected .", "entity": [{"entity": "CDC5", "entity_type": "GENE", "pos": [12, 16]}], "task": "NER"}
{"text": "Thus , the pathway to Fc epsilonRI - mediated MEK / ERK and ERK activation can apparently bypass Ras and Raf - 1 .", "entity": [{"entity": "Fc epsilonRI", "entity_type": "GENE", "pos": [22, 34]}, {"entity": "MEK", "entity_type": "GENE", "pos": [46, 49]}, {"entity": "ERK", "entity_type": "GENE", "pos": [52, 55]}, {"entity": "ERK", "entity_type": "GENE", "pos": [60, 63]}, {"entity": "Ras", "entity_type": "GENE", "pos": [97, 100]}, {"entity": "Raf - 1", "entity_type": "GENE", "pos": [105, 112]}], "task": "NER"}
{"text": "Bovine anaplasmosis : susceptibility of seronegative cows from an infected herd to experimental infection with Anaplasma marginale .", "entity": [], "task": "NER"}
{"text": "The starting dose was 8 mg / m2 administered intravenously ( IV ) as a short infusion daily for 5 days , repeated every 3 weeks with dose adjustments depending on patient tolerance .", "entity": [], "task": "NER"}
{"text": "The related adhesion focal tyrosine kinase is tyrosine - phosphorylated after beta1 - integrin stimulation in B cells and binds to p130cas .", "entity": [{"entity": "adhesion focal tyrosine kinase", "entity_type": "GENE", "pos": [12, 42]}, {"entity": "beta1 - integrin", "entity_type": "GENE", "pos": [78, 94]}, {"entity": "p130cas", "entity_type": "GENE", "pos": [131, 138]}], "task": "NER"}
{"text": "The cerebellar cortical vessels : they are compared to the cerebral vessels .", "entity": [], "task": "NER"}
{"text": "Plasma prolactin concentrations in pinealectomized ewes receiving melatonin treatment and in pineal intact ewes maintained under a non - 24 - hour photoperiod .", "entity": [{"entity": "Plasma prolactin", "entity_type": "GENE", "pos": [0, 16]}], "task": "NER"}
{"text": "After 5 days stimulation with G - CSF ( 10 micrograms / kg ) 1l of blood was drawn , kept unprocessed for 3 days and reinfused 24 h after completion of chemotherapy .", "entity": [{"entity": "G - CSF", "entity_type": "GENE", "pos": [30, 37]}], "task": "NER"}
{"text": "The species composition and abundance upon treatment of manure with polyethylene , polystyrene and glass particles was similar to that of the treatment control , i . e . natural and inert sand .", "entity": [], "task": "NER"}
{"text": "We present the case of a patient who presented an unusually large mucoid cyst measuring 38 x 25 mm in an uncommon localization , the right maxillary .", "entity": [], "task": "NER"}
{"text": "Twenty male volunteers were studied during almokalant infusion aiming at plasma concentrations ( Cpl ) of 20 , 50 , 100 , and 150 nmol / l .", "entity": [], "task": "NER"}
{"text": "Previous studies have shown that TGFbeta1 expression is upregulated in mouse keratinocytes infected with a v - rasHa retrovirus , although the functional significance of this has not been clear .", "entity": [{"entity": "TGFbeta1", "entity_type": "GENE", "pos": [33, 41]}, {"entity": "v - rasHa", "entity_type": "GENE", "pos": [107, 116]}], "task": "NER"}
{"text": "A significant difference in the distribution of antibodies to thyroglobulin and thyroid peroxidase was found in subgroup 2 .", "entity": [{"entity": "thyroglobulin", "entity_type": "GENE", "pos": [62, 75]}, {"entity": "thyroid peroxidase", "entity_type": "GENE", "pos": [80, 98]}], "task": "NER"}
{"text": "Protein kinase C ( PKC ) activation after treatment of human neuroblastoma SK - N - BE ( 2 ) C cells with phorbol 12 - myristate 13 - acetate ( PMA ) was found to enhance transcription of the human dopamine beta - hydroxylase ( DBH ) in those cells .", "entity": [{"entity": "Protein kinase C", "entity_type": "GENE", "pos": [0, 16]}, {"entity": "PKC", "entity_type": "GENE", "pos": [19, 22]}, {"entity": "dopamine beta - hydroxylase", "entity_type": "GENE", "pos": [198, 225]}, {"entity": "DBH", "entity_type": "GENE", "pos": [228, 231]}], "task": "NER"}
{"text": "Radiographic spatial frequencies essential to the diagnosis of incipient interproximal lesions .", "entity": [], "task": "NER"}
{"text": "The originally embryonic gamma - globin locus duplicated and acquired a novel ( fetal ) pattern of expression in a defined time period ( 55 - 40 million years ago ) during primate phylogeny .", "entity": [{"entity": "embryonic gamma - globin locus", "entity_type": "GENE", "pos": [15, 45]}], "task": "NER"}
{"text": "The pcaR regulatory locus has been found to be required for both induction of all of the genes within the pca regulon ( pcaBDC , pcaIJ , and pcaF ) and the chemotactic response of the bacteria to aromatic compounds .", "entity": [{"entity": "pcaR regulatory locus", "entity_type": "GENE", "pos": [4, 25]}, {"entity": "pca regulon", "entity_type": "GENE", "pos": [106, 117]}, {"entity": "pcaBDC", "entity_type": "GENE", "pos": [120, 126]}, {"entity": "pcaIJ", "entity_type": "GENE", "pos": [129, 134]}, {"entity": "pcaF", "entity_type": "GENE", "pos": [141, 145]}], "task": "NER"}
{"text": "Thus , the i - leader protein is a viral gene product of unknown function and high stability that is made in large quantities at intermediate times of productive infection . ( ABSTRACT TRUNCATED AT 400 WORDS )", "entity": [{"entity": "i - leader protein", "entity_type": "GENE", "pos": [11, 29]}], "task": "NER"}
{"text": "Consequently , during the evolution of mammals , it is the CKbeta4GT - I gene lineage that has been recruited for the biosynthesis of lactose .", "entity": [{"entity": "CKbeta4GT - I gene", "entity_type": "GENE", "pos": [59, 77]}], "task": "NER"}
{"text": "The Pi signals are conveyed to PHO8 by binding of PHO4 protein , a positive regulatory factor , to a promoter region of PHO8 ( PHO8p ) under the influence of the PHO regulatory circuit .", "entity": [{"entity": "PHO8", "entity_type": "GENE", "pos": [31, 35]}, {"entity": "PHO4 protein", "entity_type": "GENE", "pos": [50, 62]}, {"entity": "PHO8", "entity_type": "GENE", "pos": [120, 124]}, {"entity": "PHO8p", "entity_type": "GENE", "pos": [127, 132]}, {"entity": "PHO", "entity_type": "GENE", "pos": [162, 165]}], "task": "NER"}
{"text": "Direct saturation analysis", "entity": [], "task": "NER"}
{"text": "The results of the neural network were compared with those of a density mask ( thresholds , - 750 / - 300 H ) , with a radiologist serving as the gold standard .", "entity": [], "task": "NER"}
{"text": "Mutational analysis of the IME2 UAS reveals two critical sequence elements : a G + C - rich sequence ( called URS1 ) , previously identified at many meiotic genes , and a newly described element , the T4C site , that we found at a subset of meiotic genes .", "entity": [{"entity": "IME2 UAS", "entity_type": "GENE", "pos": [27, 35]}], "task": "NER"}
{"text": "We analyzed right ventricular size and function and 201Tl uptake to determine if there was a relationship between 201Tl uptake and systolic function in 19 patients with pulmonary artery hypertension who were being evaluated for heart - lung transplantation .", "entity": [], "task": "NER"}
{"text": "Clinical findings plaque index , PI ; gingival index , GI ; bleeding on probing , BOP ; pus discharge , pus ; and probing depth , PD at both PT - 01 and control sites were measured at every visit for 4 weeks .", "entity": [], "task": "NER"}
{"text": "Therefore the effect of GAL11 on PGK transcription must be mediated at the PGK UAS , presumably as part of the activation complex .", "entity": [{"entity": "GAL11", "entity_type": "GENE", "pos": [24, 29]}, {"entity": "PGK", "entity_type": "GENE", "pos": [33, 36]}, {"entity": "PGK UAS", "entity_type": "GENE", "pos": [75, 82]}], "task": "NER"}
{"text": "The authors recommend in cases with an elevated transaminase serum activity more frequent check - up examinations to avoid missing of a relapse , and to examine repeatedly IgM anti - HAV as in protracted forms of hepatitis IgM anti - HAV may persist even when the transaminase activity is normal .", "entity": [{"entity": "IgM", "entity_type": "GENE", "pos": [172, 175]}, {"entity": "anti - HAV", "entity_type": "GENE", "pos": [176, 186]}, {"entity": "IgM", "entity_type": "GENE", "pos": [223, 226]}, {"entity": "anti - HAV", "entity_type": "GENE", "pos": [227, 237]}], "task": "NER"}
{"text": "Effects were studied of extremely high - frequency electromagnetic radiation ( EHF EMR ) on indices for the immune and endocrine systems in a series of 48 patients presenting with hyperplastic processes in endometrium .", "entity": [], "task": "NER"}
{"text": "Management of patients with Ewing ' s sarcoma has been discussed with reference to the need to achieve an excellent local result from radiation therapy now that patients are experiencing long - term survival .", "entity": [], "task": "NER"}
{"text": "Effect of hyperaemia on thallium - 201 redistribution in normal canine myocardium .", "entity": [], "task": "NER"}
{"text": "After dialysis online , lactate was converted by means of lactate oxidase immobilized to porous glass , and the depletion of oxygen was registered by means of a Clark electrode .", "entity": [{"entity": "lactate oxidase", "entity_type": "GENE", "pos": [58, 73]}], "task": "NER"}
{"text": "These data show that both Sp1 and Sp3 transcription factors upregulate HGF promoter activity by binding to the Sp1 binding site at position - 318 to - 303 bp in the HGF gene promoter .", "entity": [{"entity": "Sp1", "entity_type": "GENE", "pos": [26, 29]}, {"entity": "Sp3 transcription factors", "entity_type": "GENE", "pos": [34, 59]}, {"entity": "HGF promoter", "entity_type": "GENE", "pos": [71, 83]}, {"entity": "Sp1 binding site", "entity_type": "GENE", "pos": [111, 127]}, {"entity": "HGF gene promoter", "entity_type": "GENE", "pos": [165, 182]}], "task": "NER"}
{"text": "As a member of the uncoupling protein family , UCP2 is ubiquitously expressed in rodents and humans , implicating a major role in thermogenesis .", "entity": [{"entity": "uncoupling protein family", "entity_type": "GENE", "pos": [19, 44]}, {"entity": "UCP2", "entity_type": "GENE", "pos": [47, 51]}], "task": "NER"}
{"text": "99Tcm - labelled albumin colloid , albures ( radius 250 nm ) or nanocoll ( radius 25 nm ) , or both were used as test substances to study the kinetics of vascular clearance after RES stimulation .", "entity": [{"entity": "albumin", "entity_type": "GENE", "pos": [17, 24]}], "task": "NER"}
{"text": "Hepatitis B markers in Lancashire police officers .", "entity": [], "task": "NER"}
{"text": "Xa4 is a dominantly inherited rice gene that confers resistance to Philippine race 1 of the bacterial blight pathogen Xanthomonas oryzae pv . oryzae in rice .", "entity": [{"entity": "Xa4", "entity_type": "GENE", "pos": [0, 3]}], "task": "NER"}
{"text": "Screening of human cDNA libraries has identified two different 5 ' - termini and alternatively spliced forms of the human Fli - 1 gene ( Fli - 1b ) , suggesting the possible existence of two independent promoters .", "entity": [{"entity": "human Fli - 1 gene", "entity_type": "GENE", "pos": [116, 134]}, {"entity": "Fli - 1b", "entity_type": "GENE", "pos": [137, 145]}], "task": "NER"}
{"text": "We were unable to construct chvI or chvG insertion mutants of R . meliloti , whereas mutants carrying insertions outside of these genes were readily obtained .", "entity": [{"entity": "chvI", "entity_type": "GENE", "pos": [28, 32]}, {"entity": "chvG insertion mutants", "entity_type": "GENE", "pos": [36, 58]}], "task": "NER"}
{"text": "Consistent with an effect on transcription , p21 was localized in nuclei of transfected cells .", "entity": [{"entity": "p21", "entity_type": "GENE", "pos": [45, 48]}], "task": "NER"}
{"text": "When yeast cells reach a critical size in late G1 they simultaneously start budding , initiate DNA synthesis , and activate transcription of a set of genes that includes G1 cyclins CLN1 , CLN2 , and many DNA synthesis genes .", "entity": [{"entity": "G1 cyclins", "entity_type": "GENE", "pos": [170, 180]}, {"entity": "CLN1", "entity_type": "GENE", "pos": [181, 185]}, {"entity": "CLN2", "entity_type": "GENE", "pos": [188, 192]}], "task": "NER"}
{"text": "After a 1 - h rest ( for T2 return to baseline ) , subjects repeated the 5 - min protocol , followed by a final MRI / MRS .", "entity": [], "task": "NER"}
{"text": "Use of ELISAs for the diagnosis of canine atopy .", "entity": [], "task": "NER"}
{"text": "In situ localization of PCP - A1 transcripts revealed that they accumulate specifically in pollen at the late binucleate / trinucleate stage of development rather than in the tapetum , which previously was taken to be the principal source of the pollen coat .", "entity": [{"entity": "PCP - A1 transcripts", "entity_type": "GENE", "pos": [24, 44]}], "task": "NER"}
{"text": "A single dose of Cef was administered intravenously to 11 patients with autoimmune diseases and varying degrees of renal impairment ( Group I CLCR less than 50 ml / min , Group II CLCR greater than 50 ml / min ) .", "entity": [], "task": "NER"}
{"text": "Postheparin lipoprotein lipase , measured using fat emulsion as substrate , also was significantly greater in female rats compared with males .", "entity": [{"entity": "lipoprotein lipase", "entity_type": "GENE", "pos": [12, 30]}], "task": "NER"}
{"text": "RESULTS : Here , we report the identification of two major and novel Shc tyrosine phosphorylation sites , Y239 and Y240 .", "entity": [{"entity": "Shc", "entity_type": "GENE", "pos": [69, 72]}], "task": "NER"}
{"text": "The results obtained demonstrate the applicability of countercurrent chromatography to the determination of ultratrace elements .", "entity": [], "task": "NER"}
{"text": "Based on our sequence data , ORF2 from most isolates excluding G1 encode truncated 49 aa ( pORF2a ) because of an in - frame stop codon , although ORF2s from most G1 isolates encode 202 aa ( pORF2ab ) .", "entity": [], "task": "NER"}
{"text": "Fusions between the GAL DNA binding domain and full - length mSin3 were also capable of repression .", "entity": [{"entity": "GAL DNA binding domain", "entity_type": "GENE", "pos": [20, 42]}, {"entity": "full - length mSin3", "entity_type": "GENE", "pos": [47, 66]}], "task": "NER"}
{"text": "Clinical evidence provides tentative suggestions on ( a ) possible additional risk of cigarette smoking ( b ) avoidance of venography ( c ) avoidance of varicose vein surgery .", "entity": [], "task": "NER"}
{"text": "We examined the contribution of a cryptic plasmid , pRmeGR4b , to the nodulation of Medicago sativa by strain GR4 of Rhizobium meliloti .", "entity": [], "task": "NER"}
{"text": "It is concluded that the predominant action of LSD on the female copulatory response is not mediated by increased dopamine receptor activity but that the LSD effect might be modulated by decreased dopaminergic activity .", "entity": [{"entity": "dopamine receptor", "entity_type": "GENE", "pos": [114, 131]}], "task": "NER"}
{"text": "The frequency of severe congestive heart failure ( Killip class III or IV ) at admission was significantly higher in patients with early presentation , than with late presentation ( 30 . 7 % vs 7 . 6 % , p less than 0 . 05 ) .", "entity": [], "task": "NER"}
{"text": "These findings also demonstrate that unless excluded by other factors , the C proteins are likely to be located along the length of nascent transcripts .", "entity": [{"entity": "C proteins", "entity_type": "GENE", "pos": [76, 86]}], "task": "NER"}
{"text": "ADR1 in extracts made from glucose - repressed and - derepressed cells bound UAS1 DNA with similar affinities despite having greatly different abilities to activate ADH2 gene expression in vivo .", "entity": [{"entity": "ADR1", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "ADH2 gene", "entity_type": "GENE", "pos": [165, 174]}], "task": "NER"}
{"text": "Comparing the outcome of the group having histologically normal biopsies with the group having nonspecifically abnormal ones it is concluded that frontal biopsy is not of such high prognostic value as has been claimed in previous reports .", "entity": [], "task": "NER"}
{"text": "However , using wet weight / dry weight methodology , we found that administration of U74006F significantly reduced water content in the right hippocampus ( contralateral to the site of injury ) compared to saline - treated animals ( p less than 0 . 05 ) .", "entity": [], "task": "NER"}
{"text": "A ready - made prosthesis is placed on the external side of the ribs vertically bridging the flailed chest segment , and fixed to the first upper and first lower intact rib as well as to the mobile segments of the affected ribs .", "entity": [], "task": "NER"}
{"text": "The authors suggest that alprazolam may have enhanced specificity for a subpopulation of benzodiazepine receptors .", "entity": [{"entity": "benzodiazepine receptors", "entity_type": "GENE", "pos": [89, 113]}], "task": "NER"}
{"text": "They showed moderate in vitro antifungal activity against a wide variety of fungi and yeasts including clinically important pathogens , and were highly effective in systemic infection with Candida albicans in mice after iv and im administrations .", "entity": [], "task": "NER"}
{"text": "Central ( heart rate , VE , VO2 ) or local ( muscle and blood lactate , adenosine triphosphate , creatine phosphokinase , glycogen ) cues highlighted in these studies demonstrate both the complexity of effort perception , and the need for better understanding of the physiological components upon which it is based .", "entity": [{"entity": "creatine phosphokinase", "entity_type": "GENE", "pos": [97, 119]}], "task": "NER"}
{"text": "The method was tested on 7 rats with 48 - hr - old myocardial infarction and 4 sham - operated controls .", "entity": [], "task": "NER"}
{"text": "Disruption and reconstruction : narrative insights into the experience of family members caring for a relative diagnosed with serious mental illness .", "entity": [], "task": "NER"}
{"text": "Transcription start sites of sal and salR genes were determined to lie 30 - and 24 - bp upstream of the respective initiation codons and separated from each other by 78 nucleotides .", "entity": [{"entity": "sal", "entity_type": "GENE", "pos": [29, 32]}, {"entity": "salR genes", "entity_type": "GENE", "pos": [37, 47]}], "task": "NER"}
{"text": "Co - operativity of functional domains in the muscle - specific transcription factor Myf - 5 .", "entity": [{"entity": "muscle - specific transcription factor Myf - 5", "entity_type": "GENE", "pos": [46, 92]}], "task": "NER"}
{"text": "Henry Quastler brought experience from an actual x - ray treatment , and Dr .", "entity": [], "task": "NER"}
{"text": "Hybridization was detected between polyadenylated H chain mRNA , isolated from the majority of the hybridomas , and the VH probe .", "entity": [{"entity": "polyadenylated H chain mRNA", "entity_type": "GENE", "pos": [35, 62]}, {"entity": "VH", "entity_type": "GENE", "pos": [120, 122]}], "task": "NER"}
{"text": "The general concept of RARE - cleavage mapping as well as its applications and limitations are discussed .", "entity": [{"entity": "RARE", "entity_type": "GENE", "pos": [23, 27]}], "task": "NER"}
{"text": "( 4 ) Expression in different sites in the central nervous system is driven by separable elements widely dispersed throughout 8 kb 3 ' of the gene .", "entity": [], "task": "NER"}
{"text": "Thus , an increase in lactate concentration of the magnitude observed during alkali therapy need not indicate a worsening of the metabolic picture in lactic acidosis .", "entity": [], "task": "NER"}
{"text": "The virus must progress past the immediate - early phase and express an early gene product ( s ) for activation of cyclin E expression .", "entity": [{"entity": "early gene product ( s )", "entity_type": "GENE", "pos": [72, 96]}, {"entity": "cyclin E", "entity_type": "GENE", "pos": [115, 123]}], "task": "NER"}
{"text": "The software is in BASIC adapted for the Hewlett - Packard calculators HP - 9845B and HP - 85A .", "entity": [], "task": "NER"}
{"text": "Genealogical analysis suggested mainly a mother - to - offspring transmission of this STLV - 1 .", "entity": [], "task": "NER"}
{"text": "The deduced amino - acid sequence of the mature enzyme showed very low homology ( < 20 . 4 % identity ) to those of known pectinolytic enzymes in the large pectate lyase superfamily ( the polysaccharide lyase family 1 ) .", "entity": [{"entity": "pectate lyase superfamily", "entity_type": "GENE", "pos": [156, 181]}, {"entity": "polysaccharide lyase family 1", "entity_type": "GENE", "pos": [188, 217]}], "task": "NER"}
{"text": "The pineal hormone melatonin ( MLT ) is able to exert an oncostatic action .", "entity": [], "task": "NER"}
{"text": "Patients commonly considered the external frame cumbersome .", "entity": [], "task": "NER"}
{"text": "A wound model for decubitus and leg ulcers consisting of human dermal fibroblasts in type I collagen dermal \" equivalent \" matrix ( DEM ) was exposed in vitro to electric fields similar to postulated endogenous fields in wounds .", "entity": [{"entity": "type I collagen", "entity_type": "GENE", "pos": [85, 100]}], "task": "NER"}
{"text": "In contrast to the effect on DNA replication , the L13V substitution in large T antigen did not prevent complex formation with Hsc70 and the Rb protein .", "entity": [{"entity": "large T antigen", "entity_type": "GENE", "pos": [72, 87]}, {"entity": "Hsc70", "entity_type": "GENE", "pos": [127, 132]}, {"entity": "Rb protein", "entity_type": "GENE", "pos": [141, 151]}], "task": "NER"}
{"text": "In contrast , the tail deviated ipsilaterally in cats with a hemisection , and the tail was ventroflexed in cats with a transection .", "entity": [], "task": "NER"}
{"text": "Lastly , several restriction length polymorphisms were identified and mapped within a 1 kb region located immediately upstream from the JH cluster .", "entity": [{"entity": "JH cluster", "entity_type": "GENE", "pos": [136, 146]}], "task": "NER"}
{"text": "Peak plasma ACTH responses were not significantly different between control and patient groups .", "entity": [{"entity": "ACTH", "entity_type": "GENE", "pos": [12, 16]}], "task": "NER"}
{"text": "We demonstrate inhibition of 2 - deoxyglucose uptake in isolated primary rat adipocytes and 3T3 - L1 adipocytes pretreated with U73122 .", "entity": [], "task": "NER"}
{"text": "It is likely that these recordings are incomplete ; the actual number of activated neurons is estimated to be about 300 in the acutely sensitized preparation .", "entity": [], "task": "NER"}
{"text": "In this report we describe the structure and DNA sequence of transcriptional control regions from both human and Wistar - rat single copy EGF genes and their functional analysis in epithelial cell cultures .", "entity": [{"entity": "human and Wistar - rat single copy EGF genes", "entity_type": "GENE", "pos": [103, 147]}], "task": "NER"}
{"text": "Along with these species , F . graminearum group 2 ( ZON , DON and / or 3AcDON or 15AcDON ) ; F . chlamydosporum ; F . acuminatum ( type - A trichothecene derivatives ) ; and F . semitectum were often found to be associated .", "entity": [], "task": "NER"}
{"text": "C . glabrata cells containing the CBF1 gene under the influence of a shutdown promoter ( tetO - ScHOP ) arrested their growth after 5 h of cultivation in the presence of the reactive drug doxycycline .", "entity": [{"entity": "CBF1 gene", "entity_type": "GENE", "pos": [34, 43]}], "task": "NER"}
{"text": "It was observed that muscle infarction in the IPC ( 24 + / - 2 % ) and preischemic LMK ( 21 + / - 2 % ) groups were smaller ( P < 0 . 05 ) than that in the control ( 42 + / - 2 % ) .", "entity": [], "task": "NER"}
{"text": "A characteristic feature is their tendency to form homo - and / or heterodimeric complexes .", "entity": [], "task": "NER"}
{"text": "A female infant with isolated noncompaction of ventricular myocardium who developed ventricular tachyarrhythmia is described .", "entity": [], "task": "NER"}
{"text": "Methodological considerations limiting causal assertions permissible with nonexperimental data are discussed .", "entity": [], "task": "NER"}
{"text": "Skytthe , and K .", "entity": [], "task": "NER"}
{"text": "Y1 , Y2 , and Y4 / PP1 .", "entity": [{"entity": "Y1", "entity_type": "GENE", "pos": [0, 2]}, {"entity": "Y2", "entity_type": "GENE", "pos": [5, 7]}, {"entity": "Y4", "entity_type": "GENE", "pos": [14, 16]}, {"entity": "PP1", "entity_type": "GENE", "pos": [19, 22]}], "task": "NER"}
{"text": "S - phase - promoting cyclin - dependent kinases ( Cdks ) and the kinase Dbf4 - Cdc7 then act to initiate replication .", "entity": [{"entity": "cyclin - dependent kinases", "entity_type": "GENE", "pos": [22, 48]}, {"entity": "Cdks", "entity_type": "GENE", "pos": [51, 55]}, {"entity": "Dbf4", "entity_type": "GENE", "pos": [73, 77]}, {"entity": "Cdc7", "entity_type": "GENE", "pos": [80, 84]}], "task": "NER"}
{"text": "The cleft walls are lined with highly conserved residues and NADP is bound along one wall .", "entity": [], "task": "NER"}
{"text": "The primary conditions for acceptable hospital use were that exhaled - volume monitoring be performed for all patients and that O2 monitoring be performed both when setting FIO2 and continuously when FIO2 levels are critical .", "entity": [], "task": "NER"}
{"text": "Genetic mutation or loss of activin / transforming growth factor - beta ( TGFbeta ) receptor function has been shown in human lymphoid , breast , and colorectal tumors as well as Hep2B and Mv1Lu cell lines .", "entity": [{"entity": "activin", "entity_type": "GENE", "pos": [28, 35]}, {"entity": "transforming growth factor - beta ( TGFbeta ) receptor", "entity_type": "GENE", "pos": [38, 92]}], "task": "NER"}
{"text": "Non - specific immunological abnormalities were detected in 8 of the 13 patients in whom they were looked for .", "entity": [], "task": "NER"}
{"text": "No cleavage of gp 130 was observed in analogous pulse - chase radiolabelling of Ad - gB - infected human fibroblasts , even though these cells are permissive for HCMV replication and can process the native gB molecule .", "entity": [{"entity": "gp 130", "entity_type": "GENE", "pos": [15, 21]}, {"entity": "gB", "entity_type": "GENE", "pos": [85, 87]}, {"entity": "native gB molecule", "entity_type": "GENE", "pos": [199, 217]}], "task": "NER"}
{"text": "Because levels of Vo2DIR and Vo2INDIR were similar in both groups , we pooled data from septic and control animals .", "entity": [], "task": "NER"}
{"text": "A case comparison of acquired immune deficiency syndrome ( AIDS ) in homosexual males with spindle - endothelial cell abnormalities and with recrudescent melioidosis .", "entity": [], "task": "NER"}
{"text": "OBJECTIVE : To assess laboratory practice in the examination of blood films for malarial parasites .", "entity": [], "task": "NER"}
{"text": "Little honoured in his own country : statues in recognition of Edward Jenner MD FRS .", "entity": [], "task": "NER"}
{"text": "We conclude that GRF1 and GRF2 can form homo - and hetero - oligomers via their DH domains , that mutational inactivation of oligomer formation by GRF1 is associated with impaired biological and signaling activities , and that in 293T cells GRF1 mediates at least two pathways for Raf activation : one a constitutive signal that is mainly Ras - dependent , and one an ionomycin - induced signal that cooperates with the constitutive signal without further augmenting the level of GTP - Ras .", "entity": [{"entity": "GRF1", "entity_type": "GENE", "pos": [17, 21]}, {"entity": "GRF2", "entity_type": "GENE", "pos": [26, 30]}, {"entity": "DH domains", "entity_type": "GENE", "pos": [80, 90]}, {"entity": "GRF1", "entity_type": "GENE", "pos": [147, 151]}, {"entity": "GRF1", "entity_type": "GENE", "pos": [241, 245]}, {"entity": "Raf", "entity_type": "GENE", "pos": [281, 284]}, {"entity": "Ras", "entity_type": "GENE", "pos": [339, 342]}, {"entity": "GTP - Ras", "entity_type": "GENE", "pos": [480, 489]}], "task": "NER"}
{"text": "The significance of these changes in relation to the control of phosphorus balance in ruminants is discussed .", "entity": [], "task": "NER"}
{"text": "These results extend our knowledge of this SNF2 - like family member and suggest a role for PASG in leukemogenesis .", "entity": [{"entity": "SNF2 - like family member", "entity_type": "GENE", "pos": [43, 68]}, {"entity": "PASG", "entity_type": "GENE", "pos": [92, 96]}], "task": "NER"}
{"text": "In the absence of c - fos gene expression , c - Fos protein appears to be replaced by proteins of Fos family ( Fra - 1 ) and ATF family ( ATF - 2 and ATFa ) .", "entity": [{"entity": "c - fos gene", "entity_type": "GENE", "pos": [18, 30]}, {"entity": "c - Fos protein", "entity_type": "GENE", "pos": [44, 59]}, {"entity": "Fos family", "entity_type": "GENE", "pos": [98, 108]}, {"entity": "Fra - 1", "entity_type": "GENE", "pos": [111, 118]}, {"entity": "ATF family", "entity_type": "GENE", "pos": [125, 135]}, {"entity": "ATF - 2", "entity_type": "GENE", "pos": [138, 145]}, {"entity": "ATFa", "entity_type": "GENE", "pos": [150, 154]}], "task": "NER"}
{"text": "The interaction obtained with DBM scores was further qualified by a three - way interaction that limited this pattern to participants scoring higher on self - deception .", "entity": [], "task": "NER"}
{"text": "To elucidate the molecular mechanism by which the Ras signaling pathway activates a cell - type - specific gene , we have used the pituitary - specific rat prolactin ( rPRL ) promoter as a target of oncogenic Ras and Raf in GH4 rat pituitary cells .", "entity": [{"entity": "Ras", "entity_type": "GENE", "pos": [50, 53]}, {"entity": "pituitary - specific rat prolactin", "entity_type": "GENE", "pos": [131, 165]}, {"entity": "rPRL", "entity_type": "GENE", "pos": [168, 172]}, {"entity": "oncogenic Ras", "entity_type": "GENE", "pos": [199, 212]}, {"entity": "Raf", "entity_type": "GENE", "pos": [217, 220]}], "task": "NER"}
{"text": "The results indicate that expression of proU in E . coli is directed from two promoters , one ( P2 ) characterized earlier by other workers with the start site of transcription 60 nucleotides upstream of the initiation codon of the first structural gene ( proV ) , and the other ( P1 ) situated 250 nucleotides upstream of proV .", "entity": [{"entity": "proU", "entity_type": "GENE", "pos": [40, 44]}, {"entity": "proV", "entity_type": "GENE", "pos": [256, 260]}, {"entity": "proV", "entity_type": "GENE", "pos": [323, 327]}], "task": "NER"}
{"text": "Coexpression of CREB - binding protein ( CBP ) / p300 with TReP - 132 has an additive effect on promoter activity , and the proteins were demonstrated to interact physically .", "entity": [{"entity": "CREB - binding protein", "entity_type": "GENE", "pos": [16, 38]}, {"entity": "CBP", "entity_type": "GENE", "pos": [41, 44]}, {"entity": "p300", "entity_type": "GENE", "pos": [49, 53]}, {"entity": "TReP - 132", "entity_type": "GENE", "pos": [59, 69]}], "task": "NER"}
{"text": "Thirty minutes after reperfusion , lung lymph flow ( QL ) increased from 4 . 3 to 8 . 3 ml / 30 minutes ( p less than 0 . 05 ) , lymph / plasma protein ratio was unchanged from 0 . 6 , and the lymph protein clearance increased from 2 . 6 to 4 . 6 ml / 30 minutes ( p less than 0 . 05 ) , data consistent with increased microvascular permeability .", "entity": [], "task": "NER"}
{"text": "The shift from complex I to complex II seen only in SCM - 1 - producer T cell lines upon activation was completely suppressed by cyclosporin A .", "entity": [{"entity": "SCM - 1", "entity_type": "GENE", "pos": [52, 59]}], "task": "NER"}
{"text": "Database searches revealed a 50 - 63 % similarity and 34 - 42 % identity with several families of serine proteases , in particular the trypsin - like proteases , members of the glandular kallikrein family ( including prostate - specific antigen , nerve growth factor gamma , and epidermal growth factor - binding protein ) and the activators for the kringle family proteins ( including the human tissue plasminogen activator and human hepatocyte growth factor activator ) .", "entity": [{"entity": "serine proteases", "entity_type": "GENE", "pos": [98, 114]}, {"entity": "trypsin - like proteases", "entity_type": "GENE", "pos": [135, 159]}, {"entity": "glandular kallikrein family", "entity_type": "GENE", "pos": [177, 204]}, {"entity": "prostate - specific antigen", "entity_type": "GENE", "pos": [217, 244]}, {"entity": "nerve growth factor gamma", "entity_type": "GENE", "pos": [247, 272]}, {"entity": "epidermal growth factor - binding protein", "entity_type": "GENE", "pos": [279, 320]}, {"entity": "kringle family proteins", "entity_type": "GENE", "pos": [350, 373]}, {"entity": "human tissue plasminogen activator", "entity_type": "GENE", "pos": [390, 424]}, {"entity": "human hepatocyte growth factor activator", "entity_type": "GENE", "pos": [429, 469]}], "task": "NER"}
{"text": "UPR elements present in other ER chaperone genes , such as yeast KAR2 ( BiP ) , mammalian GRP78 ( BiP ) , and GRP94 , function in an analogous manner to that in FKB2 .", "entity": [{"entity": "yeast KAR2", "entity_type": "GENE", "pos": [59, 69]}, {"entity": "BiP", "entity_type": "GENE", "pos": [72, 75]}, {"entity": "mammalian GRP78", "entity_type": "GENE", "pos": [80, 95]}, {"entity": "BiP", "entity_type": "GENE", "pos": [98, 101]}, {"entity": "GRP94", "entity_type": "GENE", "pos": [110, 115]}, {"entity": "FKB2", "entity_type": "GENE", "pos": [161, 165]}], "task": "NER"}
{"text": "No bafilomycin - sensitive ATPase is detected in a vacuolar fraction .", "entity": [{"entity": "ATPase", "entity_type": "GENE", "pos": [27, 33]}], "task": "NER"}
{"text": "The kinase domains encoded in the COOH - terminal moiety are 94 % conserved ; the NH2 - terminal moieties are approximately 65 % homologous , suggesting this region may encode sequences conferring differential regulation of the two kinases .", "entity": [], "task": "NER"}
{"text": "From this asymmetry , we suggested previously that GCN4 interacts with nonequivalent and possibly overlapping half - sites ( ATGAC and ATGAG ) that have different affinities .", "entity": [{"entity": "GCN4", "entity_type": "GENE", "pos": [51, 55]}], "task": "NER"}
{"text": "The essential questions about hepatitis C", "entity": [], "task": "NER"}
{"text": "DRAP27 is recognized by CD9 antibodies .", "entity": [{"entity": "DRAP27", "entity_type": "GENE", "pos": [0, 6]}, {"entity": "CD9 antibodies", "entity_type": "GENE", "pos": [24, 38]}], "task": "NER"}
{"text": "YACs selected from our contig will be the starting point for the cloning of the LGMD2B gene and thereby establish the biological basis for this form of muscular dystrophy and its relationship with the other limb - girdle muscular dystrophies .", "entity": [{"entity": "LGMD2B gene", "entity_type": "GENE", "pos": [80, 91]}], "task": "NER"}
{"text": "Acceptability of home monitoring as an aid to conception .", "entity": [], "task": "NER"}
{"text": "Starches had no effect .", "entity": [], "task": "NER"}
{"text": "The dominant inhibitory biological activity of the N terminus correlated with its ability to impair EGF - dependent activation of GTP - Ras and of MAP kinase , as well with the ability of endogenous Sos to form a stable complex with activated EGF receptors .", "entity": [{"entity": "EGF", "entity_type": "GENE", "pos": [100, 103]}, {"entity": "GTP - Ras", "entity_type": "GENE", "pos": [130, 139]}, {"entity": "MAP kinase", "entity_type": "GENE", "pos": [147, 157]}, {"entity": "Sos", "entity_type": "GENE", "pos": [199, 202]}, {"entity": "EGF receptors", "entity_type": "GENE", "pos": [243, 256]}], "task": "NER"}
{"text": "The tensile strengths of an adhesive luting resin ' Panavia EX ' to the bovine dentin decreased significantly by the zinc iontophoresis .", "entity": [], "task": "NER"}
{"text": "The Giessener Tumordokumentationssystem ( GTDS ) is such a disease specific system .", "entity": [], "task": "NER"}
{"text": "In addition , renal sympathetic activity was measured in a separate group of rats .", "entity": [], "task": "NER"}
{"text": "A 4 . 0 - kb Nlk message is also present during embryogenesis , detectable at day E10 .", "entity": [{"entity": "Nlk message", "entity_type": "GENE", "pos": [13, 24]}], "task": "NER"}
{"text": "The 5 - HT3 antagonist ondansetron reduced alcohol intake in both the medium and high alcohol preferring rats at doses between 0 . 01 and 0 . 16 mg / kg .", "entity": [{"entity": "5 - HT3", "entity_type": "GENE", "pos": [4, 11]}], "task": "NER"}
{"text": "In humans , there was a statistically significant decrease of TEWL on both forearm and thigh in CS - treated patients compared to non - CS - treated patients and controls ( p less than 0 . 05 ) .", "entity": [], "task": "NER"}
{"text": "Southern hybridization of genomic DNA from WT and Lp / Lp embryos failed to identify specific rearrangements at or near the Nhlh1 locus , and Northern RNA blotting and RT - PCR evaluation of Nhlh1 mRNA expression indicated that both the levels and types of Nhlh1 mRNAs produced in WT and Lp / Lp embryos were indistinguishable .", "entity": [{"entity": "Lp", "entity_type": "GENE", "pos": [50, 52]}, {"entity": "Lp", "entity_type": "GENE", "pos": [55, 57]}, {"entity": "Nhlh1 locus", "entity_type": "GENE", "pos": [124, 135]}, {"entity": "Nhlh1 mRNA", "entity_type": "GENE", "pos": [191, 201]}, {"entity": "Nhlh1 mRNAs", "entity_type": "GENE", "pos": [257, 268]}, {"entity": "Lp", "entity_type": "GENE", "pos": [288, 290]}, {"entity": "Lp", "entity_type": "GENE", "pos": [293, 295]}], "task": "NER"}
{"text": "Mutations of the human PTEN gene .", "entity": [{"entity": "human PTEN gene", "entity_type": "GENE", "pos": [17, 32]}], "task": "NER"}
{"text": "Heart rate during the behavioral avoidance test was shown to be as susceptible to experimental demand as other studies have shown approach behaviors to be influenced .", "entity": [], "task": "NER"}
{"text": "In addition , we mapped a putative hnRNP A1 binding site in U5 RNA and demonstrated that p40CRS ( hnRNP A1 ) binding to that site correlates with CRS function .", "entity": [{"entity": "hnRNP A1 binding site", "entity_type": "GENE", "pos": [35, 56]}, {"entity": "U5 RNA", "entity_type": "GENE", "pos": [60, 66]}, {"entity": "p40CRS", "entity_type": "GENE", "pos": [89, 95]}, {"entity": "hnRNP A1", "entity_type": "GENE", "pos": [98, 106]}, {"entity": "CRS", "entity_type": "GENE", "pos": [146, 149]}], "task": "NER"}
{"text": "Biochemical experiments and genome sequencing have shown that , despite the prokaryotic cell and genome organization , basal transcriptional elements of members of the domain Archaea ( i . e . , TATA box - like sequences , RNA polymerase , and transcription factors TBP , TFIIB , and TFIIS ) are of the eukaryotic type .", "entity": [{"entity": "RNA polymerase", "entity_type": "GENE", "pos": [223, 237]}, {"entity": "TBP", "entity_type": "GENE", "pos": [266, 269]}, {"entity": "TFIIB", "entity_type": "GENE", "pos": [272, 277]}, {"entity": "TFIIS", "entity_type": "GENE", "pos": [284, 289]}], "task": "NER"}
{"text": "MGF is a novel member of the cytokine - regulated transcription factor gene family .", "entity": [{"entity": "MGF", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "cytokine - regulated transcription factor gene family", "entity_type": "GENE", "pos": [29, 82]}], "task": "NER"}
{"text": "One month after administration of 131I , the 29 cats evaluated were clinically improved , and 24 ( 83 % ) of the 29 cats evaluated had normal serum T4 concentrations , 3 cats ( 10 % ) remained hyperthyroxinemic , and 2 cats ( 7 % ) were hypothyroxinemic .", "entity": [], "task": "NER"}
{"text": "Csk ( C - terminal Src kinase ) is a protein tyrosine kinase that phosphorylates Src family member C - terminal tails , resulting in downregulation of Src family members .", "entity": [{"entity": "Csk", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "C - terminal Src kinase", "entity_type": "GENE", "pos": [6, 29]}, {"entity": "protein tyrosine kinase", "entity_type": "GENE", "pos": [37, 60]}, {"entity": "Src family member C - terminal tails", "entity_type": "GENE", "pos": [81, 117]}, {"entity": "Src", "entity_type": "GENE", "pos": [151, 154]}], "task": "NER"}
{"text": "Northern blot analysis of enoyl - ACP reductase mRNA steady - state levels during seed development suggests that the increase in enzyme activity during the phase of storage lipid accumulation is regulated at the level of gene expression .", "entity": [{"entity": "enoyl - ACP reductase mRNA", "entity_type": "GENE", "pos": [26, 52]}], "task": "NER"}
{"text": "Lung transplantation is warranted for stable , ventilator - dependent recipients .", "entity": [], "task": "NER"}
{"text": "A new myocyte - specific enhancer - binding factor that recognizes a conserved element associated with multiple muscle - specific genes .", "entity": [{"entity": "myocyte - specific enhancer - binding factor", "entity_type": "GENE", "pos": [6, 50]}], "task": "NER"}
{"text": "The magnesium content in leukocytes could not be estimated because of interaction between the ion and the Percoll ( R ) media .", "entity": [], "task": "NER"}
{"text": "The need for such guidelines is clear on both clinical and scientific grounds .", "entity": [], "task": "NER"}
{"text": "This activity creates a 4 - bp staggered cut with 3 ' OH overhangs within a specific sequence of the 21S rRNA gene of omega - strains .", "entity": [{"entity": "21S rRNA gene", "entity_type": "GENE", "pos": [101, 114]}], "task": "NER"}
{"text": "Herewith C . psittaci could be diagnosed in all positive samples .", "entity": [], "task": "NER"}
{"text": "Chem .", "entity": [], "task": "NER"}
{"text": "The gene responsible for multiple endocrine neoplasia type 1 ( MEN1 ) , a heritable predisposition to endocrine tumours in man , has recently been identified .", "entity": [{"entity": "MEN1", "entity_type": "GENE", "pos": [63, 67]}], "task": "NER"}
{"text": "Is it time for a wine trial ?", "entity": [], "task": "NER"}
{"text": "We previously identified a highly conserved L - X - X - L - F sequence near the C terminus of the p6 domain of the Gag precursor as the major virion association motif for HIV - 1 Vpr .", "entity": [{"entity": "p6 domain", "entity_type": "GENE", "pos": [98, 107]}, {"entity": "Gag precursor", "entity_type": "GENE", "pos": [115, 128]}, {"entity": "HIV - 1 Vpr", "entity_type": "GENE", "pos": [171, 182]}], "task": "NER"}
{"text": "Three patients treated with amphotericin B , single course as well as multiple courses , and other antifungal agents ( hydroxystilbamidine and miconazole ) have all relapsed .", "entity": [], "task": "NER"}
{"text": "The site of acetylation of Tat was mapped to the double - lysine motif in a highly conserved region , ( 49 ) RKKRRQ ( 54 ) , of the basic RNA - binding motif of Tat .", "entity": [{"entity": "Tat", "entity_type": "GENE", "pos": [27, 30]}, {"entity": "Tat", "entity_type": "GENE", "pos": [161, 164]}], "task": "NER"}
{"text": "In contrast to Torpedo , where only a single transcript is seen , the mouse expresses several mRNAs encoding different isoforms .", "entity": [], "task": "NER"}
{"text": "trans - activation of the HIV - 1 LTR by the HIV - 1 Tat and HTLV - I Tax proteins is mediated by different cis - acting sequences .", "entity": [{"entity": "HIV - 1 LTR", "entity_type": "GENE", "pos": [26, 37]}, {"entity": "HIV - 1 Tat", "entity_type": "GENE", "pos": [45, 56]}, {"entity": "HTLV - I Tax proteins", "entity_type": "GENE", "pos": [61, 82]}], "task": "NER"}
{"text": "NSD1 contains a SET domain and multiple PHD fingers .", "entity": [{"entity": "NSD1", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "SET domain", "entity_type": "GENE", "pos": [16, 26]}], "task": "NER"}
{"text": "After 1 day , none of the labeled erythrocytes were detected .", "entity": [], "task": "NER"}
{"text": "Latex products ( gloves , balloons , and condoms ) directly bound IgE from all four patients .", "entity": [{"entity": "IgE", "entity_type": "GENE", "pos": [66, 69]}], "task": "NER"}
{"text": "The results indicate that the RNA in T7 RNA polymerase is not free of steric interactions in the ternary complex and not available for structure formation until it is at least 10 bases away from the site of polymerization .", "entity": [{"entity": "T7 RNA polymerase", "entity_type": "GENE", "pos": [37, 54]}], "task": "NER"}
{"text": "Effect of infantile undernutrition on adult sucrose solution consumption in the rat .", "entity": [], "task": "NER"}
{"text": "The transcriptional activity of P - 450 ( 11 beta ) gene was studied with an in vitro transcription system using nuclear extracts prepared from bovine adrenal cortex .", "entity": [{"entity": "P - 450 ( 11 beta ) gene", "entity_type": "GENE", "pos": [32, 56]}], "task": "NER"}
{"text": "The analysis showed that the morning active ( MA ) individuals rose earlier and went to bed earlier than the evening active ( EA ) individuals , and the former had a longer sleep length than the latter during days with a morning shift , while the opposite was true for afternoon and night shifts .", "entity": [], "task": "NER"}
{"text": "Appl .", "entity": [], "task": "NER"}
{"text": "The CHED protein includes the consensus ATP binding and phosphorylation domains characteristic of kinases , displays 34 - 42 % identically aligned amino acid residues with other cdc2 - related kinases , and is considerably longer at its amino and carboxyl termini .", "entity": [{"entity": "CHED protein", "entity_type": "GENE", "pos": [4, 16]}, {"entity": "cdc2 - related kinases", "entity_type": "GENE", "pos": [178, 200]}], "task": "NER"}
{"text": "These include urinalysis , chest X - P , ECG , hematological examinations ( RBC , WBC , Ht , Hb , PLT and ESR ) and biochemical tests ( AST , ALT , ALP , gamma GTP , LDH , CPK , Chol , T - Bil , TP , Alb , TG , BUN , Cr , Glu , Na , K , Ca , P and CRP ) .", "entity": [{"entity": "Hb", "entity_type": "GENE", "pos": [93, 95]}, {"entity": "AST", "entity_type": "GENE", "pos": [136, 139]}, {"entity": "ALT", "entity_type": "GENE", "pos": [142, 145]}, {"entity": "ALP", "entity_type": "GENE", "pos": [148, 151]}, {"entity": "gamma GTP", "entity_type": "GENE", "pos": [154, 163]}, {"entity": "LDH", "entity_type": "GENE", "pos": [166, 169]}, {"entity": "CPK", "entity_type": "GENE", "pos": [172, 175]}, {"entity": "Alb", "entity_type": "GENE", "pos": [200, 203]}, {"entity": "CRP", "entity_type": "GENE", "pos": [248, 251]}], "task": "NER"}
{"text": "We challenge each of 55 consecutive ragweed ( RW ) - allergic patients with hay fever and with graded increasing doses of ragweed extract to investigate the frequency and relationship between the early ( ER ) , late ( LPR ) , and rechallenge reactions ( RCRs ) to nasal challenge .", "entity": [], "task": "NER"}
{"text": "Vasodilator and hypotensive effects of the optical isomers of nicardipine ( YC - 93 ) , a new Ca2 + - antagonist .", "entity": [], "task": "NER"}
{"text": "The encoded protein contains an amino terminal PDZ domain , followed by a predicted coiled - coil region , a PEST domain , and a carboxy - terminal SAM domain .", "entity": [{"entity": "PDZ", "entity_type": "GENE", "pos": [47, 50]}], "task": "NER"}
{"text": "The 5 ' ends of the P and O gene mRNAs are separated by 109 nucleotide pairs in the DNA template .", "entity": [{"entity": "P", "entity_type": "GENE", "pos": [20, 21]}, {"entity": "O gene mRNAs", "entity_type": "GENE", "pos": [26, 38]}], "task": "NER"}
{"text": "Those diagnosed as having affective disorder ( n = 96 ) , according to DSM - IIIR criteria , were compared with the other non - affective suicide attempters ( n = 161 ) .", "entity": [], "task": "NER"}
{"text": "The leukotriene receptor antagonist zafirlukast inhibits sulfur dioxide - induced bronchoconstriction in patients with asthma .", "entity": [{"entity": "leukotriene receptor", "entity_type": "GENE", "pos": [4, 24]}], "task": "NER"}
{"text": "The p63 sequence also features an acidic domain characteristic of transcriptional activation factors , as well as sequence blocks displaying limited similarity to positionally equivalent regions in sigma factors from eubacteria related to mitochondria .", "entity": [{"entity": "p63 sequence", "entity_type": "GENE", "pos": [4, 16]}, {"entity": "sigma factors", "entity_type": "GENE", "pos": [198, 211]}], "task": "NER"}
{"text": "We have thus cloned two yeast homologs of mammalian p220 .", "entity": [{"entity": "mammalian p220", "entity_type": "GENE", "pos": [42, 56]}], "task": "NER"}
{"text": "A phase II clinical trial on MDS was conducted in a cooperative study with orally administrable ara - C analogue , PLAC , which is resistant to cytidine deaminase and had shown an anti - tumor activity on various experimental tumors by oral route .", "entity": [{"entity": "cytidine deaminase", "entity_type": "GENE", "pos": [144, 162]}], "task": "NER"}
{"text": "The arrangement of amino acids in the helix 1 and helix 2 regions is quite similar to those of Mxi and Mad , but different from those of E2F - 1 and DP - 1 .", "entity": [{"entity": "Mxi", "entity_type": "GENE", "pos": [95, 98]}, {"entity": "Mad", "entity_type": "GENE", "pos": [103, 106]}, {"entity": "E2F - 1", "entity_type": "GENE", "pos": [137, 144]}, {"entity": "DP - 1", "entity_type": "GENE", "pos": [149, 155]}], "task": "NER"}
{"text": "Platelets and RBCs from each animal were labeled with 51Cr and 99mTc , respectively , and were rapidly injected into the right atrium while blood was sampled from the ascending aorta .", "entity": [], "task": "NER"}
{"text": "PDGF stimulated CDK2 activity in mesangial cells and decreased the level of p27 ( kip1 ) cyclin kinase inhibitor protein .", "entity": [{"entity": "PDGF", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "CDK2", "entity_type": "GENE", "pos": [16, 20]}, {"entity": "p27", "entity_type": "GENE", "pos": [76, 79]}, {"entity": "kip1", "entity_type": "GENE", "pos": [82, 86]}], "task": "NER"}
{"text": "Furthermore , the induction of cytochrome P - 450 1A1 observed in the cormorant indicates that the Ah receptor - mediated process , by which TCDD and related chemicals exert many of their toxicities , has been activated .", "entity": [{"entity": "cytochrome P - 450 1A1", "entity_type": "GENE", "pos": [31, 53]}, {"entity": "Ah receptor", "entity_type": "GENE", "pos": [99, 110]}], "task": "NER"}
{"text": "In gel mobility shift assays , high binding activities of ATPC - 2 and low binding activities of CBF were observed with nuclear extracts from tissue with low AtpC expression levels , and the opposite was observed with extracts from tissues with high AtpC expression levels .", "entity": [{"entity": "ATPC - 2", "entity_type": "GENE", "pos": [58, 66]}, {"entity": "CBF", "entity_type": "GENE", "pos": [97, 100]}, {"entity": "AtpC", "entity_type": "GENE", "pos": [158, 162]}, {"entity": "AtpC", "entity_type": "GENE", "pos": [250, 254]}], "task": "NER"}
{"text": "A case of bilateral testicular germ cell tumors in a 23 - year - old male is reported .", "entity": [], "task": "NER"}
{"text": "Using green fluorescent protein fusions we demonstrate that the SYT , SSX and the SYT - SSX proteins are nuclear proteins .", "entity": [{"entity": "green fluorescent protein", "entity_type": "GENE", "pos": [6, 31]}, {"entity": "SYT", "entity_type": "GENE", "pos": [64, 67]}, {"entity": "SSX", "entity_type": "GENE", "pos": [70, 73]}, {"entity": "SYT", "entity_type": "GENE", "pos": [82, 85]}, {"entity": "SSX", "entity_type": "GENE", "pos": [88, 91]}], "task": "NER"}
{"text": "Thus , the mutants are deficient in production of the O - antigen polymerase and were termed rfc mutants .", "entity": [{"entity": "O - antigen polymerase", "entity_type": "GENE", "pos": [54, 76]}, {"entity": "rfc mutants", "entity_type": "GENE", "pos": [93, 104]}], "task": "NER"}
{"text": "The program for myogenic differentiation is subject to negative control by several peptide growth factors and by the products of mutationally activated ras oncogenes , which persistently activate intracellular cascades normally triggered by specific growth factors .", "entity": [{"entity": "ras oncogenes", "entity_type": "GENE", "pos": [152, 165]}], "task": "NER"}
{"text": "The p58 ( PITSLRE beta 1 ) protein kinase ( PK ) is a member of a large supergene family related to the master mitotic protein kinase , p34cdc2 .", "entity": [{"entity": "p58", "entity_type": "GENE", "pos": [4, 7]}, {"entity": "PITSLRE beta 1", "entity_type": "GENE", "pos": [10, 24]}, {"entity": "master mitotic protein kinase", "entity_type": "GENE", "pos": [104, 133]}, {"entity": "p34cdc2", "entity_type": "GENE", "pos": [136, 143]}], "task": "NER"}
{"text": "By a combination of alternative promoter usage and exon splicing , each ROR gene generates several isoforms that differ only in their amino terminus .", "entity": [{"entity": "ROR gene", "entity_type": "GENE", "pos": [72, 80]}], "task": "NER"}
{"text": "The expression pattern of LjEmx changed dramatically during embryogenesis ; expression was seen initially in the entire neural tube and mesoderm , which were secondarily downregulated , and secondarily in cranial nerve ganglia and in the craniofacial mesenchyme .", "entity": [{"entity": "LjEmx", "entity_type": "GENE", "pos": [26, 31]}], "task": "NER"}
{"text": "Similarly , antisense TGF - beta type II receptor oligodeoxynucleotides ( 40 microM ) resulted in a 58 % increase in branching , compared to scrambled and mismatched sequence controls , while TGF - beta , type II receptor mRNA and its protein expression levels were suppressed by 95 and 84 % , respectively .", "entity": [{"entity": "antisense TGF - beta type II receptor oligodeoxynucleotides ( 40 microM )", "entity_type": "GENE", "pos": [12, 85]}, {"entity": "TGF - beta , type II receptor mRNA", "entity_type": "GENE", "pos": [192, 226]}], "task": "NER"}
{"text": "Despite this loss , YEpFAS1 is still able to complement a fas1 mutation at the enoyl reductase domain .", "entity": [{"entity": "YEpFAS1", "entity_type": "GENE", "pos": [20, 27]}, {"entity": "fas1", "entity_type": "GENE", "pos": [58, 62]}, {"entity": "enoyl reductase", "entity_type": "GENE", "pos": [79, 94]}], "task": "NER"}
{"text": "In this study , a site of PDGF - induced tyrosine phosphorylation was mapped to Tyr 138 in the SH3 domain ; Tyr 138 is exposed on the SH3 peptide binding surface .", "entity": [{"entity": "PDGF", "entity_type": "GENE", "pos": [26, 30]}, {"entity": "SH3 domain", "entity_type": "GENE", "pos": [95, 105]}, {"entity": "SH3 peptide binding surface", "entity_type": "GENE", "pos": [134, 161]}], "task": "NER"}
{"text": "Our results showed that the 5 - hydroxytryptamine ( 5 - HT ) content in platelets was : ( 1 ) increased in the subgroup of anti - social alcoholics ; ( 2 ) transiently and differently altered in alcoholics compared to opiate addicts ; and ( 3 ) lowered in drinking alcoholics and normal in alcoholics who were drinking as well as smoking ( that may occur via MAO - B inhibition by smoke ) .", "entity": [{"entity": "MAO - B", "entity_type": "GENE", "pos": [359, 366]}], "task": "NER"}
{"text": "Recently , we reported that SMRT also directly associates with LAZ3 ( BCL - 6 ) , a POZ / Zn finger transcriptional repressor involvedin the pathogenesis of non - Hodgkin lymphomas .", "entity": [{"entity": "SMRT", "entity_type": "GENE", "pos": [28, 32]}, {"entity": "LAZ3", "entity_type": "GENE", "pos": [63, 67]}, {"entity": "BCL - 6", "entity_type": "GENE", "pos": [70, 77]}], "task": "NER"}
{"text": "Regulation of activating transcription factor - 1 and the cAMP response element - binding protein by Ca2 + / calmodulin - dependent protein kinases type I , II , and IV .", "entity": [{"entity": "activating transcription factor - 1", "entity_type": "GENE", "pos": [14, 49]}, {"entity": "cAMP response element - binding protein", "entity_type": "GENE", "pos": [58, 97]}, {"entity": "Ca2 + / calmodulin - dependent protein kinases type I , II , and IV", "entity_type": "GENE", "pos": [101, 168]}], "task": "NER"}
{"text": "Accordingly , constitutive downregulation of expression of accessory molecules of the MHC class I pathway can reveal differences between H2 class I alleles in antigen presentation not encountered when the expression levels are augmented .", "entity": [{"entity": "MHC class I pathway", "entity_type": "GENE", "pos": [86, 105]}, {"entity": "H2 class I alleles", "entity_type": "GENE", "pos": [137, 155]}], "task": "NER"}
{"text": "Cross - sectional studies continue to dominate .", "entity": [], "task": "NER"}
{"text": "G6620 is the 3 ' end of the MOL1 gene coding for a polypeptide similar to stress - inducible proteins from Fusarium ; G6630 is the NAT2 gene which encodes a methionine N - acetyltransferase ; G6635 is the RPL30B gene coding for the ribosomal protein L30 ; G6658 is RSR1 encoding a ras - related protein ; G6667 is CYS4 , the gene for cystathionine beta - synthase ; G6670 is identical to ORF2 located close to CYS4 ; G6673 is PEM1 / CHO2 encoding a phosphatidylethanolamine methyltransferase ; G7001 is the NSR1 gene coding for a nuclear signal recognition protein .", "entity": [{"entity": "G6620", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "MOL1 gene", "entity_type": "GENE", "pos": [28, 37]}, {"entity": "G6630", "entity_type": "GENE", "pos": [118, 123]}, {"entity": "NAT2 gene", "entity_type": "GENE", "pos": [131, 140]}, {"entity": "methionine N - acetyltransferase", "entity_type": "GENE", "pos": [157, 189]}, {"entity": "G6635", "entity_type": "GENE", "pos": [192, 197]}, {"entity": "RPL30B gene", "entity_type": "GENE", "pos": [205, 216]}, {"entity": "ribosomal protein L30", "entity_type": "GENE", "pos": [232, 253]}, {"entity": "G6658", "entity_type": "GENE", "pos": [256, 261]}, {"entity": "RSR1", "entity_type": "GENE", "pos": [265, 269]}, {"entity": "ras - related protein", "entity_type": "GENE", "pos": [281, 302]}, {"entity": "G6667", "entity_type": "GENE", "pos": [305, 310]}, {"entity": "CYS4", "entity_type": "GENE", "pos": [314, 318]}, {"entity": "cystathionine beta - synthase", "entity_type": "GENE", "pos": [334, 363]}, {"entity": "G6670", "entity_type": "GENE", "pos": [366, 371]}, {"entity": "CYS4", "entity_type": "GENE", "pos": [410, 414]}, {"entity": "G6673", "entity_type": "GENE", "pos": [417, 422]}, {"entity": "PEM1", "entity_type": "GENE", "pos": [426, 430]}, {"entity": "CHO2", "entity_type": "GENE", "pos": [433, 437]}, {"entity": "phosphatidylethanolamine methyltransferase", "entity_type": "GENE", "pos": [449, 491]}, {"entity": "G7001", "entity_type": "GENE", "pos": [494, 499]}, {"entity": "NSR1 gene", "entity_type": "GENE", "pos": [507, 516]}], "task": "NER"}
{"text": "The tau v at rest was 4 . 06 + / - 2 . 16 s and decreased to 2 . 44 + / - 1 . 07 s ( P < 0 . 05 ) at 1 Hz and to 1 . 81 + / - 0 . 4 s at 5 Hz .", "entity": [], "task": "NER"}
{"text": "This action could be antagonized by aminophylline , a competitive antagonist on P1 purinoceptors .", "entity": [{"entity": "P1 purinoceptors", "entity_type": "GENE", "pos": [80, 96]}], "task": "NER"}
{"text": "In the predicted amino acid sequence of NPS1 , sequences homologous to the catalytic domain of protein kinases were found .", "entity": [{"entity": "NPS1", "entity_type": "GENE", "pos": [40, 44]}], "task": "NER"}
{"text": "The cDNA contains a reading frame for a 145 - amino - acid protein and it lacks the UGA codons , which have been found in the reading frame of the mouse MCS cDNA and have been presumed to encode the selenocysteine in the amino terminal of the deduced mouse amino acid sequence .", "entity": [{"entity": "mouse MCS cDNA", "entity_type": "GENE", "pos": [147, 161]}], "task": "NER"}
{"text": "It differed significantly by country ( from 2 . 4 % in the United Kingdom to 24 . 7 % in Portugal ) and by transmission category ( 2 . 7 % among homo / bisexuals , 5 . 8 % among injecting drug users , 13 . 6 % among heterosexual subgroup 1 ) .", "entity": [], "task": "NER"}
{"text": "A definition of bias founded on the concept of the study base .", "entity": [], "task": "NER"}
{"text": "The results showed differential activation of each parahippocampal region during verbal memory tasks in which the side activated shifted depending on the nature of the task employed ; an increase in rCBF in the left parahippocampal gyrus was associated with retrieval strategy of non - matching , and an increase in rCBF in the right parahippocampal gyrus was associated with retrieval strategy of matching .", "entity": [], "task": "NER"}
{"text": "Cells were co - infected simultaneously with IBV , the recombinant FPV ( rFPV ) containing the D - RNA sequence and a second rFPV expressing T7 RNA polymerase for the initial expression of the D - RNA transcript , subsequently rescued by helper IBV .", "entity": [{"entity": "T7 RNA polymerase", "entity_type": "GENE", "pos": [141, 158]}], "task": "NER"}
{"text": "Antigen dose - response curves were drawn , and the cumulative dose required for a 35 % reduction in specific airway conductance was calculated and designated Provocation Dose ( PD35 ) .", "entity": [], "task": "NER"}
{"text": "The use of the two pharmacokinetic parameters , t1 / 2 and Cltp , as indices of drug elimination ability are discussed .", "entity": [], "task": "NER"}
{"text": "The rapid decrease of plasma potassium during the first two hours of standard HD causes a membrane hyperpolarization .", "entity": [], "task": "NER"}
{"text": "The more sustained effect of cyclofenil on prolactin secretion with a reduced frequency of relapse , and the lower oestradiol level , which might indicate a reduced risk of thromboembolism , suggest that this drug has some advantage over bromocriptine in the inhibition of postpartum lactation .", "entity": [{"entity": "prolactin", "entity_type": "GENE", "pos": [43, 52]}], "task": "NER"}
{"text": "Therefore prostaglandin E2 is characterized in relation to prostaglandin F2 - alpha not only by a stronger uterine effectiveness , but also at the same time a pronounced influence on the cardiovascular system .", "entity": [], "task": "NER"}
{"text": "Epithelial cell - specific activation is achieved by the cooperative interaction of apparently ubiquitous transcriptional factors .", "entity": [], "task": "NER"}
{"text": "This set of genetic and physical interactions suggests a role for yeast RNA - binding proteins in transcriptional regulation .", "entity": [], "task": "NER"}
{"text": "In group 1 , mean z - score for GFR was - 0 . 27 ( 94 . 6 % of normal ) and in group 2 mean z - score was - 1 . 51 ( 72 . 7 % of normal for two kidneys ) ( P = 0 . 022 , Mann - Whitney U - test ) .", "entity": [], "task": "NER"}
{"text": "A new B - cell - specific enhancer element has been identified 3 ' of E4 and the octamerlike motifs in the human immunoglobulin heavy - chain gene enhancer .", "entity": [{"entity": "E4", "entity_type": "GENE", "pos": [70, 72]}, {"entity": "human immunoglobulin heavy - chain gene enhancer", "entity_type": "GENE", "pos": [107, 155]}], "task": "NER"}
{"text": "The mutants retained the parental ability to participate in intergeneric coaggregation with human oral actinomyces , indicating the specificity of the mutation in altering intrageneric coaggregations .", "entity": [], "task": "NER"}
{"text": "Electrically induced undulations and their competition with electrically induced convection in cholesteric liquid crystals .", "entity": [], "task": "NER"}
{"text": "Critical review of general results", "entity": [], "task": "NER"}
{"text": "A visibly distinct muscular hypertrophy ( mh ) , commonly known as double muscling , occurs with high frequency in the Belgian Blue and Piedmontese cattle breeds .", "entity": [], "task": "NER"}
{"text": "The LS gene promoter sequence has homology with Escherichia coli promoter sequences ; its terminator sequence is capable of forming a stem - and - loop structure .", "entity": [{"entity": "LS gene promoter sequence", "entity_type": "GENE", "pos": [4, 29]}], "task": "NER"}
{"text": "The apparent binding constant of 6 to calf thymus DNA is 1 . 68 X 10 ( 5 ) M - 1 whereas netropsin under similar conditions gives a value of 1 . 85 X 10 ( 7 ) M - 1 .", "entity": [{"entity": "netropsin", "entity_type": "GENE", "pos": [89, 98]}], "task": "NER"}
{"text": "Computed tomographic ( CT ) findings of pancreatic ductal adenocarcinoma were studied with the combined method of early enhancement CT and high dose enhancement CT in 72 carcinomas .", "entity": [], "task": "NER"}
{"text": "Southern hybridization analysis of BenR and BenS transformants suggested that plasmid integration occurred most frequently at the chromosomal bens locus , however evidence for gene conversion and heterologous recombination was also observed .", "entity": [{"entity": "BenR", "entity_type": "GENE", "pos": [35, 39]}, {"entity": "BenS transformants", "entity_type": "GENE", "pos": [44, 62]}, {"entity": "bens locus", "entity_type": "GENE", "pos": [142, 152]}], "task": "NER"}
{"text": "Recombinant mouse GSTT1 - 1 was catalytically active towards 1 , 2 - epoxy - 3 - ( p - nitrophenoxy ) propane , 4 - nitrobenzyl chloride and dichloromethane .", "entity": [{"entity": "Recombinant mouse GSTT1 - 1", "entity_type": "GENE", "pos": [0, 27]}], "task": "NER"}
{"text": "The amount of overlap in VFI , EF , and RVF values among the clinical groups was considerable .", "entity": [], "task": "NER"}
{"text": "In pituitary GH3 cells , vitamin D increases the levels of PRL transcripts and stimulates the PRL promoter .", "entity": [{"entity": "PRL transcripts", "entity_type": "GENE", "pos": [59, 74]}, {"entity": "PRL promoter", "entity_type": "GENE", "pos": [94, 106]}], "task": "NER"}
{"text": "Neonatal masculinization affects maternal behavior sensitivity in female rats .", "entity": [], "task": "NER"}
{"text": "The Thrombolysis in Myocardial Infarction ( TIMI ) Phase II Trial randomized 3 , 339 patients to either an invasive ( INV , n = 1 , 681 ) or a conservative ( CON , n = 1 , 658 ) strategy after intravenous recombinant tissue - type plasminogen activator ( rt - PA ) for acute myocardial infarction .", "entity": [{"entity": "recombinant tissue - type plasminogen activator", "entity_type": "GENE", "pos": [205, 252]}, {"entity": "rt - PA", "entity_type": "GENE", "pos": [255, 262]}], "task": "NER"}
{"text": "Present investigation was undertaken to elucidate what pharmacokinetic parameters in animal experiment could be of more predictable for human clinical trial of beta - blocking agents .", "entity": [], "task": "NER"}
{"text": "Association of Smads with lymphoid enhancer binding factor 1 / T cell - specific factor mediates cooperative signaling by the transforming growth factor - beta and wnt pathways .", "entity": [{"entity": "Smads", "entity_type": "GENE", "pos": [15, 20]}, {"entity": "lymphoid enhancer binding factor 1", "entity_type": "GENE", "pos": [26, 60]}, {"entity": "T cell - specific factor", "entity_type": "GENE", "pos": [63, 87]}, {"entity": "transforming growth factor - beta", "entity_type": "GENE", "pos": [126, 159]}, {"entity": "wnt", "entity_type": "GENE", "pos": [164, 167]}], "task": "NER"}
{"text": "In the univariate models of either fixed or time dependent covariates , many variables were significantly associated with risk of progression to AIDS ( T4 cell count , T4 / T8 ratio , blastogenic responses to phytohemagglutinin , concanavalin A , and pokeweed mitogen , serum IgA , appearance of p24 antigen , and the development of oral hairy leukoplakia , thrush , or herpes zoster ) .", "entity": [{"entity": "phytohemagglutinin", "entity_type": "GENE", "pos": [209, 227]}, {"entity": "concanavalin A", "entity_type": "GENE", "pos": [230, 244]}, {"entity": "pokeweed mitogen", "entity_type": "GENE", "pos": [251, 267]}, {"entity": "serum IgA", "entity_type": "GENE", "pos": [270, 279]}, {"entity": "p24 antigen", "entity_type": "GENE", "pos": [296, 307]}], "task": "NER"}
{"text": "But , when mated males built nests in the absence of young , T levels were higher than in all other conditions , though only for early broods .", "entity": [], "task": "NER"}
{"text": "RESULTS : At short dwell times , uncorrected ( whole plasma ) D / P and Cp of urea values were higher than the corrected ( plasma water ) values by 5 . 7 % - 5 . 9 % .", "entity": [], "task": "NER"}
{"text": "However , there are some cows that fail to produce adequate 1 , 25 - dihydroxyvitamin D at the onset of lactation .", "entity": [], "task": "NER"}
{"text": "The AmyI specific 3 ' - UTR is characterized by the absence of IR sequences and the presence of a putative ' AATAAA ' polyadenylation signal .", "entity": [{"entity": "AmyI", "entity_type": "GENE", "pos": [4, 8]}], "task": "NER"}
{"text": "Off - shell effect in Rydberg - atom - alkali - metal - atom scattering .", "entity": [], "task": "NER"}
{"text": "We examined the mechanisms by which two different types of photonic radiation , short wavelength UV ( UV - C ) and gamma radiation , activate transcription factor NF - kappaB .", "entity": [{"entity": "NF - kappaB", "entity_type": "GENE", "pos": [163, 174]}], "task": "NER"}
{"text": "To examine the biochemical mechanism of Tax1 transactivation , we have developed an in vitro transactivation assay in which wild - type Tax1 is able to specifically transactivate a polymerase II promoter through upstream Tax1 - responsive elements .", "entity": [{"entity": "Tax1", "entity_type": "GENE", "pos": [40, 44]}, {"entity": "Tax1", "entity_type": "GENE", "pos": [136, 140]}, {"entity": "polymerase II", "entity_type": "GENE", "pos": [181, 194]}, {"entity": "Tax1 - responsive elements", "entity_type": "GENE", "pos": [221, 247]}], "task": "NER"}
{"text": "The atf1 + gene of Schizosaccharomyces pombe encodes a bZIP transcription factor with strong homology to the mammalian factor ATF - 2 .", "entity": [{"entity": "atf1 + gene of Schizosaccharomyces pombe", "entity_type": "GENE", "pos": [4, 44]}, {"entity": "bZIP transcription factor", "entity_type": "GENE", "pos": [55, 80]}, {"entity": "mammalian factor ATF - 2", "entity_type": "GENE", "pos": [109, 133]}], "task": "NER"}
{"text": "Cotransfection experiments revealed that both hGATA - 4 and PMA / A23187 stimulation are necessary for the IL - 5 promoter activation .", "entity": [{"entity": "hGATA - 4", "entity_type": "GENE", "pos": [46, 55]}, {"entity": "IL - 5 promoter", "entity_type": "GENE", "pos": [107, 122]}], "task": "NER"}
{"text": "( 5 ) .", "entity": [], "task": "NER"}
{"text": "Prenatal diagnosis of genetic diseases .", "entity": [], "task": "NER"}
{"text": "Mortality rates were not different ( chi2 : 0 . 0298 , p > 0 . 5 ) .", "entity": [], "task": "NER"}
{"text": "M . , Apps , D .", "entity": [], "task": "NER"}
{"text": "Cox proportional hazard analysis identified dialysis modality and pre - dialysis UV of less than 1 , 000 ml / m2 per 24 h as the only significant risk factors for UV survival .", "entity": [], "task": "NER"}
{"text": "The sequence of the 25 - kDa chain of the alpha subunit was found in a cDNA clone , and the amino acid sequence deduced from the cDNA establishes the complete amino acid sequence of the 25 - kDa chain .", "entity": [], "task": "NER"}
{"text": "The Gastrointestinal Tumor Study Group ( GITSG ) protocol GI - 7175 randomized 227 patients between 1975 and 1980 following complete surgical resection of stages B2 and C rectal adenocarcinoma to four treatment arms : ( 1 ) no adjuvant therapy , ( 2 ) chemotherapy only , ( 3 ) radiotherapy only , and ( 4 ) radiotherapy and chemotherapy ( combined modality ) .", "entity": [], "task": "NER"}
{"text": "Samples ( 1 g ) were extracted with 0 . 5 % potassium chloride ( KCl ) in 70 % methanol ( 5 ml ) and diluted subsequently to give two - fold to ten - fold step - wise dilutions in phosphate - buffered saline containing 0 . 05 % Tween 20 and 0 . 2 % bovine serum albumin ( PBS - T BSA ) .", "entity": [{"entity": "bovine serum albumin", "entity_type": "GENE", "pos": [249, 269]}, {"entity": "BSA", "entity_type": "GENE", "pos": [280, 283]}], "task": "NER"}
{"text": "A total of 4 , 916 children were examined and the questionnaire satisfactorily completed by a relative or guardian ( usually the mother ) of 4 , 651 .", "entity": [], "task": "NER"}
{"text": "Using community development approaches .", "entity": [], "task": "NER"}
{"text": "Cell lines expressing single amino acid substitutions of the carboxyl - terminal asparagine of CD2 are incapable of avidity regulation by TCR signaling , PMA treatment , or elevation of intracellular cAMP levels , demonstrating that each of these stimuli utilizes a common structural element for regulating CD2 avidity .", "entity": [{"entity": "CD2", "entity_type": "GENE", "pos": [95, 98]}, {"entity": "TCR", "entity_type": "GENE", "pos": [138, 141]}, {"entity": "CD2", "entity_type": "GENE", "pos": [307, 310]}], "task": "NER"}
{"text": "Iomazenil - SPECT revealed a highly significant increase in the benzodiazepine receptor uptake in all studied cortical regions except temporal cortices .", "entity": [{"entity": "benzodiazepine receptor", "entity_type": "GENE", "pos": [64, 87]}], "task": "NER"}
{"text": "These findings suggest that PGE1 is effective in increasing PVF in the liver transplanted condition ; however , the hepatic circulatory improvement attributed to this agent would be limited to the first few days following transplantation .", "entity": [], "task": "NER"}
{"text": "However , in a variation of this assay in which the protease is omitted , the mutant enzymes exhibited substantial levels of prolyl isomerase activity ( 5 - 20 % of wild - type ) , revealing that these mutations confer sensitivity to protease digestion and that the classic in vitro assay for prolyl isomerase activity may be misleading .", "entity": [{"entity": "prolyl isomerase", "entity_type": "GENE", "pos": [125, 141]}, {"entity": "prolyl isomerase", "entity_type": "GENE", "pos": [293, 309]}], "task": "NER"}
{"text": "The WEB2 gene encodes a 1 , 522 - amino - acid protein with homology to nucleic acid - dependent ATPases .", "entity": [{"entity": "WEB2 gene", "entity_type": "GENE", "pos": [4, 13]}, {"entity": "nucleic acid - dependent ATPases", "entity_type": "GENE", "pos": [72, 104]}], "task": "NER"}
{"text": "V - ErbB - mediated complex formation and transformation have been shown to occur independently of Ras activation .", "entity": [{"entity": "V - ErbB - mediated complex", "entity_type": "GENE", "pos": [0, 27]}, {"entity": "Ras", "entity_type": "GENE", "pos": [99, 102]}], "task": "NER"}
{"text": "The three OAS genes are flanked by markers WI - 10614 ( cen ) and D12S2293 ( tel ) and are contained within three sets of overlapping cosmid clones .", "entity": [{"entity": "OAS genes", "entity_type": "GENE", "pos": [10, 19]}, {"entity": "markers WI - 10614", "entity_type": "GENE", "pos": [35, 53]}, {"entity": "cen", "entity_type": "GENE", "pos": [56, 59]}, {"entity": "D12S2293", "entity_type": "GENE", "pos": [66, 74]}, {"entity": "tel", "entity_type": "GENE", "pos": [77, 80]}], "task": "NER"}
{"text": "5 ' - Deletion of the Stat - binding sites abolished all promoter - reporter activity in response to PRL .", "entity": [{"entity": "Stat - binding sites", "entity_type": "GENE", "pos": [22, 42]}, {"entity": "PRL", "entity_type": "GENE", "pos": [101, 104]}], "task": "NER"}
{"text": "Increasing the height of the agar column overlying the SN fabric diminished the inhibitory effect of SN on microbial growth .", "entity": [], "task": "NER"}
{"text": "However , differential utilization of these determinants mediate RAR - RXR heterodimer binding to DR - 2 and DR - 5 RAREs .", "entity": [{"entity": "RAR", "entity_type": "GENE", "pos": [65, 68]}, {"entity": "RXR", "entity_type": "GENE", "pos": [71, 74]}], "task": "NER"}
{"text": "Biochem .", "entity": [], "task": "NER"}
{"text": "Conversely , as a GAL - 4 chimera , the isolated LAZ3 / BCL6 BTB / POZ domain appears nearly as efficient as the entire protein at inducing transcriptional repression .", "entity": [{"entity": "GAL - 4 chimera", "entity_type": "GENE", "pos": [18, 33]}, {"entity": "LAZ3", "entity_type": "GENE", "pos": [49, 53]}, {"entity": "BCL6", "entity_type": "GENE", "pos": [56, 60]}, {"entity": "BTB", "entity_type": "GENE", "pos": [61, 64]}], "task": "NER"}
{"text": "When expressed in Escherichia coli , SH - PTP2 displays tyrosine - specific phosphatase activity .", "entity": [{"entity": "SH - PTP2", "entity_type": "GENE", "pos": [37, 46]}, {"entity": "tyrosine - specific phosphatase", "entity_type": "GENE", "pos": [56, 87]}], "task": "NER"}
{"text": "It is hypothesized this occurs through antagonism of PML / RAR alpha actions in these leukemic cells .", "entity": [{"entity": "PML", "entity_type": "GENE", "pos": [53, 56]}, {"entity": "RAR alpha", "entity_type": "GENE", "pos": [59, 68]}], "task": "NER"}
{"text": "The main new features of this version are that end - tidal PO2 instead of inspiratory PO2 can be kept constant , and that the correcting activity of both controllers ( capnostat and oxystat ) is proportional to the magnitude of the difference between the actual and the adjusted end - tidal PCO2 or PO2 .", "entity": [], "task": "NER"}
{"text": "Fli - 1 is a proto - oncogene which is rearranged in tumors induced by three different retroviruses , Cas - Br - E , F - MuLV , and 10A1 .", "entity": [{"entity": "Fli - 1", "entity_type": "GENE", "pos": [0, 7]}], "task": "NER"}
{"text": "Routine imaging modalities revealed a total of 79 metastases .", "entity": [], "task": "NER"}
{"text": "Cervical CT revealed an irregular low density at the periphery of the cervical vertebra from the C2 to C4 level .", "entity": [], "task": "NER"}
{"text": "Human myotonic dystrophy protein kinase ( DMPK ) is a member of a novel class of multidomain protein kinases that regulate cell size and shape in a variety of organisms .", "entity": [{"entity": "Human myotonic dystrophy protein kinase", "entity_type": "GENE", "pos": [0, 39]}, {"entity": "DMPK", "entity_type": "GENE", "pos": [42, 46]}], "task": "NER"}
{"text": "The MAP kinase kinase kinase MLK2 co - localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3 .", "entity": [{"entity": "MAP kinase kinase kinase", "entity_type": "GENE", "pos": [4, 28]}, {"entity": "MLK2", "entity_type": "GENE", "pos": [29, 33]}, {"entity": "JNK", "entity_type": "GENE", "pos": [64, 67]}, {"entity": "kinesin superfamily", "entity_type": "GENE", "pos": [107, 126]}, {"entity": "KIF3", "entity_type": "GENE", "pos": [133, 137]}], "task": "NER"}
{"text": "Sequential immunoprecipitation showed all detectable p53 to be of the PAb246 + class in each LPV - transformed cell line , suggesting that the stable p53 was indeed wild type .", "entity": [{"entity": "p53", "entity_type": "GENE", "pos": [53, 56]}, {"entity": "PAb246 +", "entity_type": "GENE", "pos": [70, 78]}, {"entity": "p53", "entity_type": "GENE", "pos": [150, 153]}], "task": "NER"}
{"text": "In this study , transcriptional fusions were constructed between the xcpP and xcpR genes and the lacZ reporter .", "entity": [{"entity": "xcpP", "entity_type": "GENE", "pos": [69, 73]}, {"entity": "xcpR genes", "entity_type": "GENE", "pos": [78, 88]}, {"entity": "lacZ reporter", "entity_type": "GENE", "pos": [97, 110]}], "task": "NER"}
{"text": "Increased platelet - derived growth factor production and intimal thickening during healing of Dacron grafts in a canine model .", "entity": [{"entity": "platelet - derived growth factor", "entity_type": "GENE", "pos": [10, 42]}], "task": "NER"}
{"text": "Interestingly , the NES mutant proteins appeared to have altered interactions with the splicing complex , binding more tightly to SC35 in co - immunoprecipitation assays .", "entity": [{"entity": "NES mutant proteins", "entity_type": "GENE", "pos": [20, 39]}, {"entity": "SC35", "entity_type": "GENE", "pos": [130, 134]}], "task": "NER"}
{"text": "The results of these studies indicate that EHV - 1 gp13 is the structural homolog of herpes simplex virus glycoprotein C and further suggest that the epitope - containing N - terminal amino acid sequences of the herpesvirus gC - like glycoproteins have undergone more extensive evolutionary divergence than the C - terminal sequences .", "entity": [{"entity": "EHV - 1 gp13", "entity_type": "GENE", "pos": [43, 55]}, {"entity": "herpes simplex virus glycoprotein C", "entity_type": "GENE", "pos": [85, 120]}, {"entity": "herpesvirus gC - like glycoproteins", "entity_type": "GENE", "pos": [212, 247]}], "task": "NER"}
{"text": "Previously , a cDNA ( GT2 ) encoding this protein was isolated from a mouse 3T3 - L1 adipocyte library and was sequenced .", "entity": [{"entity": "GT2", "entity_type": "GENE", "pos": [22, 25]}], "task": "NER"}
{"text": "By RT - PCR , different levels of E75 expression can be detected in the epidermis , nerve cord and the eyestalk of early pre - molt shrimp .", "entity": [{"entity": "E75", "entity_type": "GENE", "pos": [34, 37]}], "task": "NER"}
{"text": "PATIENTS : 33 HIV - infected , zidovudine - experienced patients with serum HIV RNA levels of at least 20 , 000 copies / mL and CD4 counts ranging from 50 to 400 cells / mm3 .", "entity": [{"entity": "CD4", "entity_type": "GENE", "pos": [128, 131]}], "task": "NER"}
{"text": "The potential biological significance of the identified structural motif shared by the human CCR5 , CCR3 , CCR2B and other GPCRs is discussed .", "entity": [{"entity": "human CCR5", "entity_type": "GENE", "pos": [87, 97]}, {"entity": "CCR3", "entity_type": "GENE", "pos": [100, 104]}, {"entity": "CCR2B", "entity_type": "GENE", "pos": [107, 112]}, {"entity": "GPCRs", "entity_type": "GENE", "pos": [123, 128]}], "task": "NER"}
{"text": "Materials are presented of a comparative study of morphological and cultural properties and virulence of liophylized cultures of Leishmania tropica major after their rehydration or after a long passage on the NNN medium .", "entity": [], "task": "NER"}
{"text": "The chromosomal location of these YACs was verified using FISH , which also demonstrated their nonchimeric nature .", "entity": [], "task": "NER"}
{"text": "There is no indication from these experiments that linker histones bind fundamentally differently to 5 S and bulk nucleosomes .", "entity": [{"entity": "linker histones", "entity_type": "GENE", "pos": [51, 66]}, {"entity": "5 S", "entity_type": "GENE", "pos": [101, 104]}], "task": "NER"}
{"text": "Gas chromatographic analysis of headspace samples of alkalinized vaginal discharges indicated the presence of trimethylamine in all 11 samples with the fishy odor but not in the other samples .", "entity": [], "task": "NER"}
{"text": "To investigate the step of spliceosome assembly at which Snu17p acts , we have used nondenaturing gel electrophoresis .", "entity": [{"entity": "Snu17p", "entity_type": "GENE", "pos": [57, 63]}], "task": "NER"}
{"text": "The transcription start site was identified by primer extension analysis and over 800 bp of 5 ' flanking DNA was sequenced .", "entity": [], "task": "NER"}
{"text": "PURPOSE : To evaluate the effect of adding a pulsating bristle action to the established oscillating / rotating action of the Braun Oral - B Ultra Plaque Remover ( D9 ) on plaque removal .", "entity": [], "task": "NER"}
{"text": "In contrast , postmitotic neurons possessed extremely low levels of E2F1 protein as assessed by the electrophoretic mobility shift assay and Western blotting .", "entity": [{"entity": "E2F1 protein", "entity_type": "GENE", "pos": [68, 80]}], "task": "NER"}
{"text": "The high degree of sequence conservation together with the ability to direct nucleolar protein transport supports the hypothesis that MAK16 proteins play a key role in the biogenesis of 60S subunits .", "entity": [{"entity": "MAK16 proteins", "entity_type": "GENE", "pos": [134, 148]}, {"entity": "60S subunits", "entity_type": "GENE", "pos": [186, 198]}], "task": "NER"}
{"text": "NO2 pollution on major trunk roads frequently exceeded British and European Union air quality standards , while particle pollution was lower .", "entity": [], "task": "NER"}
{"text": "The human RFC - 1 gene differs from the mouse and hamster genes both in terms of the total number of exons and in regard to alternatives of exon 1 which encode 5 ' end heterogeneity .", "entity": [{"entity": "RFC - 1 gene", "entity_type": "GENE", "pos": [10, 22]}], "task": "NER"}
{"text": "Computer analysis , simple correlation hypothesis , and distribution method with 1 degree of freedom revealed significant correlation between vertical root fracture and the technique of instrumentation and obturation of the canal ( p = 0 . 025 ) , the length of the post ( p = 0 . 05 ) , and the existence of the post ( p = 0 . 05 ) .", "entity": [], "task": "NER"}
{"text": "CrkII and CrkL constitutively formed complex with the guanine nucleotide exchange factor C3G , in unstimulated as well as PDGF - stimulated cells .", "entity": [{"entity": "CrkII", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "CrkL", "entity_type": "GENE", "pos": [10, 14]}, {"entity": "guanine nucleotide exchange factor", "entity_type": "GENE", "pos": [54, 88]}, {"entity": "C3G", "entity_type": "GENE", "pos": [89, 92]}, {"entity": "PDGF", "entity_type": "GENE", "pos": [122, 126]}], "task": "NER"}
{"text": "Plasmid subclones of recombinant phage lambda Asm152 were able to complement both Escherichia coli gltB and A . sesbaniae Asm - Vi mutants ; NADPH - glutamate synthase activity was detected in all such strains complemented to Asm + .", "entity": [{"entity": "Escherichia coli gltB", "entity_type": "GENE", "pos": [82, 103]}, {"entity": "NADPH - glutamate synthase", "entity_type": "GENE", "pos": [141, 167]}], "task": "NER"}
{"text": "Any respectative material ( class 0 ) was not obtained from 334 patients ( 4 . 2 % ) , class I - II findings belonged to 6m141 patients ( 76 . 7 % ) , 950 patients ( 11 . 9 % ) were classified as class HII and IV , 578 patients ( 7 . 2 % ) as class V .", "entity": [], "task": "NER"}
{"text": "DSIP was found to significantly increase slow - waves ( delta sleep ) in the sleep EEG .", "entity": [], "task": "NER"}
{"text": "YDL003w ( also termed MCD1 ) is a homologue of Schizosaccharomyces pombe rad21 , an essential gene implicated in DNA double - strand break repair and nuclear organization in fission yeast .", "entity": [{"entity": "YDL003w", "entity_type": "GENE", "pos": [0, 7]}, {"entity": "MCD1", "entity_type": "GENE", "pos": [22, 26]}, {"entity": "Schizosaccharomyces pombe rad21", "entity_type": "GENE", "pos": [47, 78]}], "task": "NER"}
{"text": "The oral movements which did occur in the HAL - treated rats were slower than normal .", "entity": [], "task": "NER"}
{"text": "The recombinant L / F - transferase is as active as the previously purified wild type enzyme and contains no detectable RNA component .", "entity": [{"entity": "recombinant L / F - transferase", "entity_type": "GENE", "pos": [4, 35]}], "task": "NER"}
{"text": "AST activity in PMNs was significantly low , approximately 2 % of that observed in HPLFs .", "entity": [{"entity": "AST", "entity_type": "GENE", "pos": [0, 3]}], "task": "NER"}
{"text": "Two courses of chemotherapy ( CBCDA + VDS ) failed to gain any improvement , and the pain resulting from recurrent bone metastases was managed mainly by the administration of the best supportive care .", "entity": [], "task": "NER"}
{"text": "Intraspinal and mediastinal foregut cyst compressing the spinal cord .", "entity": [], "task": "NER"}
{"text": "The H5 mutants were : DH5 ( all amino acids in D configuration ) and H5F ( where all His are replaced by Phe at positions 3 , 7 , 8 , 15 , 18 , 19 , 21 ) .", "entity": [{"entity": "H5 mutants", "entity_type": "GENE", "pos": [4, 14]}, {"entity": "DH5", "entity_type": "GENE", "pos": [22, 25]}, {"entity": "H5F", "entity_type": "GENE", "pos": [69, 72]}], "task": "NER"}
{"text": "Accordingly , infection of IFN - pretreated HeLa S3 cells with an E3L - deficient VV ( VVDeltaE3L ) resulted in increased phosphorylation levels of both PKR and eIF2alpha .", "entity": [{"entity": "IFN", "entity_type": "GENE", "pos": [27, 30]}, {"entity": "PKR", "entity_type": "GENE", "pos": [153, 156]}, {"entity": "eIF2alpha", "entity_type": "GENE", "pos": [161, 170]}], "task": "NER"}
{"text": "The human sequence contains the element TGACTCT that also is found in a murine ras - responsive enhancer .", "entity": [{"entity": "murine ras - responsive enhancer", "entity_type": "GENE", "pos": [72, 104]}], "task": "NER"}
{"text": "GAGA factor is known to remodel the chromatin structure in concert with nucleosome - remodeling factor NURF in a Drosophila embryonic S150 extract .", "entity": [{"entity": "GAGA factor", "entity_type": "GENE", "pos": [0, 11]}, {"entity": "nucleosome - remodeling factor", "entity_type": "GENE", "pos": [72, 102]}, {"entity": "NURF", "entity_type": "GENE", "pos": [103, 107]}], "task": "NER"}
{"text": "We report the complete nucleotide sequence of the camC gene along with 155 base pairs of 5 ' and 175 base pairs of 3 ' flanking sequence .", "entity": [{"entity": "camC gene", "entity_type": "GENE", "pos": [50, 59]}], "task": "NER"}
{"text": "After 30 weeks of amifostine therapy , the morphology of the MDS switched to a chronic myelomonocytic leukemia ( CMML ) - like appearance , with continuously increasing leukocytes , so that we discontinued amifostine therapy for 1 month to exclude a possible side effect of amifostine .", "entity": [], "task": "NER"}
{"text": "A gene with a high degree of sequence identity with mammalian ADP - ribosylation factors ( ARFs ) , believed to be important in vesicular transport , was identified .", "entity": [{"entity": "mammalian ADP - ribosylation factors", "entity_type": "GENE", "pos": [52, 88]}, {"entity": "ARFs", "entity_type": "GENE", "pos": [91, 95]}], "task": "NER"}
{"text": "Theophylline QID , TID , BID and now QD ? A report on 24 - hour dosing with slow - release theophylline formulations with emphasis on analyses of data used to obtain Food and Drug Administration approval for Theo - 24 .", "entity": [], "task": "NER"}
{"text": "We anticipated SNS function after CVA to be asymmetric and selected null hypotheses of bilaterally symmetric SSR latencies and amplitudes irrespective of side of stimulation and / or recording .", "entity": [], "task": "NER"}
{"text": "Taken together , these results demonstrate that the BSMV coat protein is the sole translation product of the genomic RNA beta , whereas sgRNA beta 1 serves as a messenger for translation of the beta b protein , and sgRNA beta 2 functions as a messenger for translation of beta c and beta d and the newly discovered beta d ' protein .", "entity": [{"entity": "BSMV coat protein", "entity_type": "GENE", "pos": [52, 69]}, {"entity": "genomic RNA beta", "entity_type": "GENE", "pos": [109, 125]}, {"entity": "sgRNA beta 1", "entity_type": "GENE", "pos": [136, 148]}, {"entity": "beta b protein", "entity_type": "GENE", "pos": [194, 208]}, {"entity": "sgRNA beta 2", "entity_type": "GENE", "pos": [215, 227]}, {"entity": "beta c", "entity_type": "GENE", "pos": [272, 278]}, {"entity": "beta d", "entity_type": "GENE", "pos": [283, 289]}, {"entity": "beta d ' protein", "entity_type": "GENE", "pos": [315, 331]}], "task": "NER"}
{"text": "Without a team , there is little hope for fetal survival ; mortality will be 80 - 100 % .", "entity": [], "task": "NER"}
{"text": "Thus , the search for genetic and acquired susceptibility to nontuberculous mycobacteria is also a search for susceptibility factors for MTB as well as an opportunity to recognize endogenous pathways that can be exploited therapeutically .", "entity": [], "task": "NER"}
{"text": "This gene is divided into six exons spanning about 3kb , and encodes a 175 amino acid protein with 40 - 52 % identity with the other five mouse Reg ( regenerating gene product ) proteins .", "entity": [{"entity": "mouse Reg", "entity_type": "GENE", "pos": [138, 147]}, {"entity": "regenerating gene product", "entity_type": "GENE", "pos": [150, 175]}], "task": "NER"}
{"text": "The RNA , whether antisense , ribozyme , or RNA aptamer , must be efficiently transcribed , stabilized against rapid degradation , folded correctly , and directed to the part of the cell where it can be most effective .", "entity": [], "task": "NER"}
{"text": "Interconversions between haloperidol and reduced haloperidol in schizophrenic patients and guinea pigs : a steady - state study .", "entity": [], "task": "NER"}
{"text": "PEAP was significantly higher in IDC patients compared to controls ( 48 . 7 + / - 32 . 6 vs .", "entity": [], "task": "NER"}
{"text": "Recurrent infections , episodic lymphopenia and impaired cellular immunity .", "entity": [], "task": "NER"}
{"text": "Bilirubin and red cell metabolism in relation to neonatal jaundice .", "entity": [], "task": "NER"}
{"text": "In this report , we describe a patient with renal cell carcinoma who experienced ventricular tachycardia while undergoing treatment with high - dose bolus IL - 2 .", "entity": [{"entity": "IL - 2", "entity_type": "GENE", "pos": [155, 161]}], "task": "NER"}
{"text": "We report the cloning of the ade1 gene on a 4 . 4 kb Sau3A insert in the yeast shuttle vector pWH5 .", "entity": [{"entity": "ade1 gene", "entity_type": "GENE", "pos": [29, 38]}, {"entity": "4 . 4 kb Sau3A insert", "entity_type": "GENE", "pos": [44, 65]}], "task": "NER"}
{"text": "We found that secretion of chitinolytic enzymes by cultured L . major parasites is inhibited by blood or hemoglobin , and hence these enzymes are apparently absent from the blood - fed infected flies , where the cardiac valve appears undamaged .", "entity": [{"entity": "hemoglobin", "entity_type": "GENE", "pos": [105, 115]}], "task": "NER"}
{"text": "Oral hypoglycemic agents", "entity": [], "task": "NER"}
{"text": "Identification and characterization of a yeast gene encoding the U2 small nuclear ribonucleoprotein particle B \" protein .", "entity": [{"entity": "U2 small nuclear ribonucleoprotein particle B \" protein", "entity_type": "GENE", "pos": [65, 120]}], "task": "NER"}
{"text": "The false positive fraction ( FPF ) decreased significantly if the count density increased ; no difference in FPF was found for a change in lesion tracer concentration .", "entity": [], "task": "NER"}
{"text": "Members of the CRE - binding protein ( CREB ) / activating transcription factor transcription family as well as members of the Jun / Fos family have been shown to bind to this sequence .", "entity": [{"entity": "CRE - binding protein", "entity_type": "GENE", "pos": [15, 36]}, {"entity": "CREB", "entity_type": "GENE", "pos": [39, 43]}, {"entity": "activating transcription factor", "entity_type": "GENE", "pos": [48, 79]}, {"entity": "Jun", "entity_type": "GENE", "pos": [127, 130]}, {"entity": "Fos", "entity_type": "GENE", "pos": [133, 136]}], "task": "NER"}
{"text": "Nature of the thermopower in bipolar semiconductors .", "entity": [], "task": "NER"}
{"text": "Overexpression of SNURF in cultured mammalian cells enhanced not only androgen , glucocorticoid , and progesterone receptor - dependent transactivation but also basal transcription from steroid - regulated promoters .", "entity": [{"entity": "SNURF", "entity_type": "GENE", "pos": [18, 23]}, {"entity": "progesterone receptor", "entity_type": "GENE", "pos": [102, 123]}], "task": "NER"}
{"text": "Long - range mapping by pulse - field gel electrophoresis indicated that the three mdr genes are closely linked on a genomic DNA segment of approximately 625 kilobases .", "entity": [{"entity": "mdr genes", "entity_type": "GENE", "pos": [83, 92]}], "task": "NER"}
{"text": "Oral basal body temperature ( BBT ) recordings of 46 women that conceived by donor insemination and who had midcycle monitoring of luteinising hormone ( LH ) were analysed to establish features associated with an optimal cycle .", "entity": [{"entity": "luteinising hormone", "entity_type": "GENE", "pos": [131, 150]}, {"entity": "LH", "entity_type": "GENE", "pos": [153, 155]}], "task": "NER"}
{"text": "At the start of the performance ride , plasma glucose averaged 4 . 2 + / - 0 . 2 , 5 . 2 + / - 0 . 1 , and 5 . 7 + / - 0 . 2 mmol . l - 1 in CON , CHO - 7 , and CHO - 0 / 21 , respectively ( all different , P < 0 . 05 ) .", "entity": [], "task": "NER"}
{"text": "Adhesion was inhibited by mAbs against the COOH - terminus and central cell binding domains of fibronectin , as well as by the corresponding CS1 and RGD peptides .", "entity": [{"entity": "fibronectin", "entity_type": "GENE", "pos": [95, 106]}, {"entity": "CS1", "entity_type": "GENE", "pos": [141, 144]}, {"entity": "RGD peptides", "entity_type": "GENE", "pos": [149, 161]}], "task": "NER"}
{"text": "Usher syndrome 1C ( USH1C ) is a congenital condition manifesting profound hearing loss , the absence of vestibular function , and eventual retinal degeneration .", "entity": [], "task": "NER"}
{"text": "We have determined the complete cDNA sequence of rat plectin from a number of well - characterized overlapping lambda gt11 clones .", "entity": [{"entity": "rat plectin", "entity_type": "GENE", "pos": [49, 60]}], "task": "NER"}
{"text": "Minute virus of mice NS1 , an 83 - kDa mainly nuclear phosphoprotein , is the only viral nonstructural protein required in all cell types and it is involved in multiple processes necessary for virus propagation .", "entity": [{"entity": "Minute virus of mice NS1", "entity_type": "GENE", "pos": [0, 24]}], "task": "NER"}
{"text": "On the basis of these findings we suggest that the acceptor peptide binds the transferase in a beta - like conformation and that penultimate residue side chain steric interactions may play a role in determining extent that a given Ser or Thr is glycosylated .", "entity": [], "task": "NER"}
{"text": "A higher median proportion of spirochaetes was observed in sites after diagnosis of loss of attachment .", "entity": [], "task": "NER"}
{"text": "Conventional and digital radiography of the heart , aorta , and pulmonary vascularity .", "entity": [], "task": "NER"}
{"text": "Copyright 1998 Academic Press .", "entity": [], "task": "NER"}
{"text": "Although cDNA encoding a human phagocyte formyl peptide - binding protein has been reported recently ( Boulay , F . , Tardif , M . , Brouchon , L . , and Vignais , P .", "entity": [{"entity": "human phagocyte formyl peptide - binding protein", "entity_type": "GENE", "pos": [25, 73]}], "task": "NER"}
{"text": "These results suggest that the PVB therapy is not sufficient to cure the cases with choriocarcinoma element or bulky metastasis .", "entity": [], "task": "NER"}
{"text": "METHODS : A spatial counting approach in which the location of each and every PN and NP in the stratum pyramidale of sectors CA1 - 4 was applied to 11 normal control ( CONs ) and 10 SZs matched for age and postmortem interval , as well as 4 manic depressive ( MD ) subjects matched for age .", "entity": [], "task": "NER"}
{"text": "No effect of 4 beta - phorbol 12 - myristate 13 - acetate was observed on the expression of hnRNP H .", "entity": [{"entity": "hnRNP H", "entity_type": "GENE", "pos": [92, 99]}], "task": "NER"}
{"text": "For large breasts ( > 70 mm ) the use of X - ray sets such as the IGE DMR , which automatically select the beam quality for each breast , resulted in lower doses compared with sets using manual tube potential selection .", "entity": [], "task": "NER"}
{"text": "First , ste12Delta cells differ from cells with disruptions of the upstream signaling elements ( e . g . , ste4Delta , ste20Delta , ste5Delta , ste11Delta , ste7Delta , or fus3Delta kss1Delta cells ) in that they clearly retain some capacity for inducing Ste3p phosphorylation .", "entity": [{"entity": "ste12Delta", "entity_type": "GENE", "pos": [8, 18]}, {"entity": "ste4Delta", "entity_type": "GENE", "pos": [107, 116]}, {"entity": "ste20Delta", "entity_type": "GENE", "pos": [119, 129]}, {"entity": "ste5Delta", "entity_type": "GENE", "pos": [132, 141]}, {"entity": "ste11Delta", "entity_type": "GENE", "pos": [144, 154]}, {"entity": "ste7Delta", "entity_type": "GENE", "pos": [157, 166]}, {"entity": "fus3Delta", "entity_type": "GENE", "pos": [172, 181]}, {"entity": "kss1Delta", "entity_type": "GENE", "pos": [182, 191]}, {"entity": "Ste3p", "entity_type": "GENE", "pos": [255, 260]}], "task": "NER"}
{"text": "The Valpha and Vbeta domains have the canonical features of known teleost and mammalian TCR V domains , including conserved residues in the beginning of FR2 and at the end of FR3 .", "entity": [{"entity": "Valpha", "entity_type": "GENE", "pos": [4, 10]}, {"entity": "Vbeta domains", "entity_type": "GENE", "pos": [15, 28]}, {"entity": "teleost and mammalian TCR V domains", "entity_type": "GENE", "pos": [66, 101]}, {"entity": "FR2", "entity_type": "GENE", "pos": [153, 156]}, {"entity": "FR3", "entity_type": "GENE", "pos": [175, 178]}], "task": "NER"}
{"text": "Asthma diagnoses were made according to recommended National Asthma Expert Panel Guidelines .", "entity": [], "task": "NER"}
{"text": "The atpA reading frame ends with four tandem UGA codons which overlap four tandem AUG codons initiating an unidentified reading frame , orf214 .", "entity": [{"entity": "atpA", "entity_type": "GENE", "pos": [4, 8]}], "task": "NER"}
{"text": "Deletion mutagenesis of the promoter indicated that a positive regulatory element ( PRE ) was likely to exist downstream of the UL94 mRNA start site , while a negative regulatory element ( NRE ) was present upstream of the TATA box .", "entity": [{"entity": "UL94 mRNA start site", "entity_type": "GENE", "pos": [128, 148]}], "task": "NER"}
{"text": "An ERp60 - like protein from the filarial parasite Dirofilaria immitis has both transglutaminase and protein disulfide isomerase activity .", "entity": [{"entity": "ERp60 - like protein", "entity_type": "GENE", "pos": [3, 23]}], "task": "NER"}
{"text": "Fos / Jun bound to an unacetylated nucleosome with only a 4 - to 5 - fold reduction in DNA binding affinity compared with naked DNA .", "entity": [{"entity": "Fos", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "Jun", "entity_type": "GENE", "pos": [6, 9]}], "task": "NER"}
{"text": "Pediatric patients - - handle with care .", "entity": [], "task": "NER"}
{"text": "K .", "entity": [], "task": "NER"}
{"text": "The extent of myocardial ischemia in the coronary sinus study was significantly correlated to the coronary diameters of the proximal and middle segments of the Ramus interventricularis anterior and the middle segment of the Ramus circumflexus ( r = 0 . 87 , p < 0 . 02 ) .", "entity": [], "task": "NER"}
{"text": "S1 nuclease analysis of the RNA from a number of QT6 - LD clones gave similar results , indicating that the LD population was composed of viruses with similar but not identical deletion endpoints .", "entity": [{"entity": "S1 nuclease", "entity_type": "GENE", "pos": [0, 11]}], "task": "NER"}
{"text": "The prevalence of ocular / adnexal SCC was significantly greater for all hair colors when compared with bay , brown , or black ( P less than 0 . 01 ) .", "entity": [], "task": "NER"}
{"text": "ZNS , in the mmolar range , scavenged hydroxyl and nitric oxide radicals in a dose - dependent manner .", "entity": [], "task": "NER"}
{"text": "Murine ELAM - 1 is encoded by a single - copy gene , spanning about 13 kb , which is structurally organized into 14 exons and 13 introns ; very similar to that of its human counterpart .", "entity": [{"entity": "Murine ELAM - 1", "entity_type": "GENE", "pos": [0, 15]}], "task": "NER"}
{"text": "The three more slower migrating Stat5B bands observed in response to GH contain phosphorylated tyrosyl residues .", "entity": [{"entity": "Stat5B", "entity_type": "GENE", "pos": [32, 38]}, {"entity": "GH", "entity_type": "GENE", "pos": [69, 71]}], "task": "NER"}
{"text": "Protection levels of 33 . 3 % , 36 . 6 % and 37 . 0 % were achieved in groups which had received , respectively , 1000 20 - krad cercariae , 1000 10 - krad cercariae , 2000 40 - krad cercariae and 2000 60 - krad cercariae .", "entity": [], "task": "NER"}
{"text": "During the 1st week of treatment all subjects received either mianserin 30 mg or clomipramine 75 mg once daily .", "entity": [], "task": "NER"}
{"text": "EMBO ( Eur .", "entity": [], "task": "NER"}
{"text": "When stratifying FLM values < 34 and > 34 wks ' gestation , again no difference was found in mean difference of L / S and LB before and after 34 wks .", "entity": [], "task": "NER"}
{"text": "Are there any lessons to be learnt ?", "entity": [], "task": "NER"}
{"text": "The other five from within the SRO may provide an entrance point for the cloning of candidate genes for neuroblastoma .", "entity": [], "task": "NER"}
{"text": "Three distinct human HDACs are homologous to RPD3 , a yeast transcriptional regulator .", "entity": [{"entity": "human HDACs", "entity_type": "GENE", "pos": [15, 26]}, {"entity": "RPD3", "entity_type": "GENE", "pos": [45, 49]}], "task": "NER"}
{"text": "The longest cDNA insert identified was 2 . 2 kb and encoded the entire 462 - amino acid open reading frame of rat CgA including an 18 - amino acid hydrophobic signal peptide .", "entity": [{"entity": "rat CgA", "entity_type": "GENE", "pos": [110, 117]}], "task": "NER"}
{"text": "The vaccine was at least 80 % efficacious against Chlamydia and Campylobacter spp and appeared to be protective .", "entity": [], "task": "NER"}
{"text": "The RPC31 gene encoding the C31 subunit of Saccharomyces cerevisiae RNA polymerase C ( III ) has been isolated , starting from a C - terminal fragment cloned on a lambda gt11 library .", "entity": [{"entity": "RPC31 gene", "entity_type": "GENE", "pos": [4, 14]}, {"entity": "C31 subunit of Saccharomyces cerevisiae RNA polymerase C ( III )", "entity_type": "GENE", "pos": [28, 92]}], "task": "NER"}
{"text": "Slowly adapting type I mechanoreceptor discharge as a function of dynamic force versus dynamic displacement of glabrous skin of raccoon and squirrel monkey hand .", "entity": [], "task": "NER"}
{"text": "The goal of this investigation was to determine whether BMIPP uptake can be used to differentiate viable myocardium from scar tissue soon after coronary thrombolysis for acute myocardial infarction .", "entity": [], "task": "NER"}
{"text": "The same slice was imaged three times each with sequences using spatial presaturation or not .", "entity": [], "task": "NER"}
{"text": "IRIS / GAS DNA also formed a number of specific complexes with constitutively expressed factors , none of which were affected by the above Abs .", "entity": [{"entity": "IRIS", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "GAS", "entity_type": "GENE", "pos": [7, 10]}], "task": "NER"}
{"text": "Making sense out of oxygen sensor .", "entity": [], "task": "NER"}
{"text": "Recovery rates of energy level and intracellular pH during stimulation at 100Hz were greater than those observed during stimulation at 30Hz .", "entity": [], "task": "NER"}
{"text": "The Zn - 15 DNA - binding domain comprises three zinc fingers separated by unusually long linker sequences that would be expected to interrupt specific DNA site recognition .", "entity": [{"entity": "Zn - 15 DNA - binding domain", "entity_type": "GENE", "pos": [4, 32]}], "task": "NER"}
{"text": "The data obtained included 1 ) the mean frequency of abnormal teased myelinated fibers and its upper limit value of 95 % confidence interval , and 2 ) the mean densities of total , large and small myelinated fibers and of unmyelinated fibers and their lower limit value of 95 % confidence interval for each decade .", "entity": [], "task": "NER"}
{"text": "The yield of endocervical cells and the incidence of dysplasia was determined for both the prenatal and the postpartum Pap smears performed for this group of patients .", "entity": [], "task": "NER"}
{"text": "Others as for example C - 11 labeled short chain fatty acids are on the horizon .", "entity": [], "task": "NER"}
{"text": "We conclude that the BR - C early gene directly activates late gene transcription by interacting with late gene cis - acting regulatory elements and that this interaction is responsible for the temporal linkage of early and late ecdysone - induced gene expression .", "entity": [{"entity": "BR - C early gene", "entity_type": "GENE", "pos": [21, 38]}, {"entity": "late gene", "entity_type": "GENE", "pos": [58, 67]}, {"entity": "late gene", "entity_type": "GENE", "pos": [102, 111]}], "task": "NER"}
{"text": "Exogenous heart stress raised log circulating NE concentration in proportion to the rise in heart rate at a given work load so that the usual relationship between these variables , previously observed during other stresses , was preserved .", "entity": [], "task": "NER"}
{"text": "We tested the hypothesis that PEH is associated with reductions in TPR and sympathetic nerve activity ( SNA ) .", "entity": [], "task": "NER"}
{"text": "A short conserved motif is required for repressor domain function in the myeloid - specific transcription factor CCAAT / enhancer - binding protein epsilon .", "entity": [{"entity": "CCAAT / enhancer - binding protein epsilon", "entity_type": "GENE", "pos": [113, 155]}], "task": "NER"}
{"text": "Purified fER exhibited a distribution constant ( KD ) for 17 beta - estradiol of 0 . 45 nM .", "entity": [{"entity": "fER", "entity_type": "GENE", "pos": [9, 12]}], "task": "NER"}
{"text": "However , strains in which both of the two most highly related genes , DdPIK1 and DdPIK2 , were disrupted showed both growth and developmental defects , while double knockouts of DdPIK1 and DdPIK3 and DdPIK2 and DdPIK3 appear to be lethal .", "entity": [{"entity": "DdPIK1", "entity_type": "GENE", "pos": [71, 77]}, {"entity": "DdPIK2", "entity_type": "GENE", "pos": [82, 88]}, {"entity": "DdPIK1", "entity_type": "GENE", "pos": [179, 185]}, {"entity": "DdPIK3", "entity_type": "GENE", "pos": [190, 196]}, {"entity": "DdPIK2", "entity_type": "GENE", "pos": [201, 207]}, {"entity": "DdPIK3", "entity_type": "GENE", "pos": [212, 218]}], "task": "NER"}
{"text": "The exon sequences determined from genomic DNA sequencing showed some differences when compared to the published rat GLUT2 cDNA .", "entity": [{"entity": "rat GLUT2 cDNA", "entity_type": "GENE", "pos": [113, 127]}], "task": "NER"}
{"text": "48 . 35 + / - 5 . 07 mg / l in R3 ; p < 0 . 05 ) and in the AUC ( 0 . 50 h ) ( 1429 . 92 + / - 284 . 23 in PR vs .", "entity": [], "task": "NER"}
{"text": "This integration results in the production of MMTV / mdr3 fusion transcripts that originate from the antisense 5 ' LTR of the provirus .", "entity": [{"entity": "MMTV / mdr3 fusion transcripts", "entity_type": "GENE", "pos": [46, 76]}, {"entity": "5 ' LTR", "entity_type": "GENE", "pos": [111, 118]}], "task": "NER"}
{"text": "This surface in specimens from unfertilized eggs is almost flat .", "entity": [], "task": "NER"}
{"text": "Following 40 min \" ischemia \" , preparations treated with PC recovered from transmural conduction block more rapidly ( PC1 group , 4 min , P less than 0 . 05 ; PC2 group , 23 min , ns ) , compared to control . ( ABSTRACT TRUNCATED AT 250 WORDS )", "entity": [], "task": "NER"}
{"text": "These results are discussed in the context of a model of the myogenic lineage that is based on the expression of desmin .", "entity": [{"entity": "desmin", "entity_type": "GENE", "pos": [113, 119]}], "task": "NER"}
{"text": "Characterization of a DEAD box ATPase / RNA helicase protein of Arabidopsis thaliana .", "entity": [{"entity": "DEAD box ATPase", "entity_type": "GENE", "pos": [22, 37]}, {"entity": "RNA helicase", "entity_type": "GENE", "pos": [40, 52]}], "task": "NER"}
{"text": "The host range ( HR ) of poliovirus is thought to be primarily determined by a cell surface molecule that functions as poliovirus receptor ( PVR ) , since it has been shown that transgenic mice are made poliovirus sensitive by introducing the human PVR gene into the genome .", "entity": [{"entity": "poliovirus receptor", "entity_type": "GENE", "pos": [119, 138]}, {"entity": "PVR", "entity_type": "GENE", "pos": [141, 144]}, {"entity": "human PVR gene", "entity_type": "GENE", "pos": [243, 257]}], "task": "NER"}
{"text": "In this paper , the authors used measured weight for 1 , 259 white women aged 65 - 74 years from the Epidemiologic Follow - up Study of the First National Health and Nutrition Examination Survey to examine the effect of overweight on coronary heart disease incidence ( mean length of follow - up , 14 years ) .", "entity": [], "task": "NER"}
{"text": "In contrast to the reciprocal effects of Gab1 and Gab2 in mediating Elk - 1 induction , these two molecules have a similar function in extracellular signal - regulated kinase activation induced by either oncogenic Ras or growth factor stimulation .", "entity": [{"entity": "Gab1", "entity_type": "GENE", "pos": [41, 45]}, {"entity": "Gab2", "entity_type": "GENE", "pos": [50, 54]}, {"entity": "Elk - 1", "entity_type": "GENE", "pos": [68, 75]}, {"entity": "extracellular signal - regulated kinase", "entity_type": "GENE", "pos": [135, 174]}, {"entity": "Ras", "entity_type": "GENE", "pos": [214, 217]}], "task": "NER"}
{"text": "We were able to demonstrate a significant statistical interaction effect between gender and globulin protein concentration on Vu ( p = 0 . 022 ) .", "entity": [{"entity": "globulin protein", "entity_type": "GENE", "pos": [92, 108]}], "task": "NER"}
{"text": "The NS - 2 isoforms were resolved at a pI value close to 5 . 5 as three groups of unevenly phosphorylated polypeptides , each composed of at least two protein species .", "entity": [{"entity": "NS - 2 isoforms", "entity_type": "GENE", "pos": [4, 19]}], "task": "NER"}
{"text": "Effect of isobarin on electrocardiographic indices in hypertensive disease", "entity": [], "task": "NER"}
{"text": "The column densities of frozen molecular hydrogen and methanol are inferred to be about 2 . 5 x 10 ( 18 ) and 3 . 0 x 10 ( 19 ) , respectively .", "entity": [], "task": "NER"}
{"text": "TAAG sites that serve as functional late promoters in OpMNPV were found to mediate transcription initiation at only basal levels in the context of the AcMNPV genome , suggesting that late promoter activation may be virus specific within the family Baculoviridae .", "entity": [], "task": "NER"}
{"text": "The carboxyl globular domain was found to be encoded by six exons which appear to delineate its structural subdomains .", "entity": [], "task": "NER"}
{"text": "In 3 of the 5 patients with AVNRT and AJR , junctional beats served as a trigger for reentry .", "entity": [], "task": "NER"}
{"text": "Fus3p and Kss1p together increase the expression of CLN3 and PCL2 genes that promote budding , and Kss1p inhibits the MAP kinase cascade .", "entity": [{"entity": "Fus3p", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "Kss1p", "entity_type": "GENE", "pos": [10, 15]}, {"entity": "CLN3", "entity_type": "GENE", "pos": [52, 56]}, {"entity": "PCL2 genes", "entity_type": "GENE", "pos": [61, 71]}, {"entity": "Kss1p", "entity_type": "GENE", "pos": [99, 104]}, {"entity": "MAP kinase", "entity_type": "GENE", "pos": [118, 128]}], "task": "NER"}
{"text": "Measurement of the spectral sensitivity and the ERG can thus help in the diagnosis of these three hereditary diseases .", "entity": [], "task": "NER"}
{"text": "On both indocyanine green video and fluorescein angiography , hypofluorescent lesions were almost the same size as the light yellow area and the dark yellow center of a placoid lesion .", "entity": [], "task": "NER"}
{"text": "Other similar patients must be found before it is established that the colloid cyst is part of the nevoid basal cell carcinoma syndrome .", "entity": [], "task": "NER"}
{"text": "Coexpression of C / EBP alpha altered the cell specificity .", "entity": [{"entity": "C / EBP alpha", "entity_type": "GENE", "pos": [16, 29]}], "task": "NER"}
{"text": "Dominant - negative mutations in the G - protein - coupled alpha - factor receptor map to the extracellular ends of the transmembrane segments .", "entity": [{"entity": "G - protein - coupled alpha - factor receptor", "entity_type": "GENE", "pos": [37, 82]}], "task": "NER"}
{"text": "Possibility of using gynecologic nurses in the independently administered health centers", "entity": [], "task": "NER"}
{"text": "Platelet count and plasma volume were significantly higher in group A than in group B throughout pregnancy .", "entity": [], "task": "NER"}
{"text": "The complexity of some of the reports of VACURG studies has led some to believe that this group was opposed to estrogens , but that is not true .", "entity": [], "task": "NER"}
{"text": "This increase is not the result of alterations in the deposition of inhaled particles of capsaicin brought about by volume restriction .", "entity": [], "task": "NER"}
{"text": "Mycobacterium tuberculosis inhibits IFN - gamma transcriptional responses without inhibiting activation of STAT1 .", "entity": [{"entity": "IFN - gamma", "entity_type": "GENE", "pos": [36, 47]}, {"entity": "STAT1", "entity_type": "GENE", "pos": [107, 112]}], "task": "NER"}
{"text": "Pituitary thyrotropic adenoma associated with congenital hypothyroidism .", "entity": [], "task": "NER"}
{"text": "Upstream of the afa - 3 gene cluster , a 1 . 2 - kb region was found to be 96 % identical to the RepFIB sequence of one of the enterotoxigenic E . coli plasmids ( P307 ) , suggesting a common ancestor plasmid .", "entity": [{"entity": "afa - 3 gene cluster", "entity_type": "GENE", "pos": [16, 36]}, {"entity": "RepFIB sequence", "entity_type": "GENE", "pos": [97, 112]}], "task": "NER"}
{"text": "Maintenance metabolizable - energy ( ME ) requirement averaged 31 . 0 kcal / kg body wt .", "entity": [], "task": "NER"}
{"text": "Interferon - alpha inducibility of IFI16 may be regulated by an interferon - alpha / beta - stimulated response consensus element in the 5 ' UT exon , as a similar motif is conserved in the corresponding position in the related myeloid cell nuclear differentiation antigen gene . ( ABSTRACT TRUNCATED AT 400 WORDS )", "entity": [{"entity": "Interferon - alpha", "entity_type": "GENE", "pos": [0, 18]}, {"entity": "IFI16", "entity_type": "GENE", "pos": [35, 40]}, {"entity": "interferon - alpha / beta", "entity_type": "GENE", "pos": [64, 89]}, {"entity": "myeloid cell nuclear differentiation antigen", "entity_type": "GENE", "pos": [228, 272]}], "task": "NER"}
{"text": "The secondary end points included creatine kinase peak , ventricular fibrillation / tachycardia within the first 24 hours , death and congestive heart failure within the 30 - day follow - up , and 30 - day left ventricular ejection fraction .", "entity": [{"entity": "creatine kinase", "entity_type": "GENE", "pos": [34, 49]}], "task": "NER"}
{"text": "For the population of patients with melanoma levels III and IV significant differences in survival rate were associated with thickness ( less than 2 mm or greater than or equal to 2 mm ; p less than 0 , 001 ) , though not with level .", "entity": [], "task": "NER"}
{"text": "Here we show that the sck1 gene , cloned as a high copy number suppressor of a mutation in git3 , is able to suppress the defects conferred by a mutation in any of these git genes .", "entity": [{"entity": "sck1 gene", "entity_type": "GENE", "pos": [22, 31]}, {"entity": "git3", "entity_type": "GENE", "pos": [91, 95]}, {"entity": "git genes", "entity_type": "GENE", "pos": [170, 179]}], "task": "NER"}
{"text": "The contribution of reviewers and editors to the scientific work of the authors", "entity": [], "task": "NER"}
{"text": "Comparisons of defective HTLV - I proviruses predict the mode of origin and coding potential of internally deleted genomes .", "entity": [], "task": "NER"}
{"text": "When proper controls were used , the psychophysical data and computer simulation gave remarkably comparable results .", "entity": [], "task": "NER"}
{"text": "Results of these in vitro studies may be relevant to the pathogenesis of alveolitis in organic dust - induced lung diseases .", "entity": [], "task": "NER"}
{"text": "However , the in vivo attachment strength of the CSTi - 2 coating was comparable both to CSTi - 1 and to an HA - coated control after 8 weeks .", "entity": [], "task": "NER"}
{"text": "The phosphoprotein pUL69 of human cytomegalovirus ( HCMV ) , which is a herpesvirus of considerable medical importance in immunosuppressed patients and newborns , has previously been identified as an early - late viral protein that can stimulate several viral and cellular promoters and thus exerts a rather broad activation pattern .", "entity": [{"entity": "phosphoprotein pUL69", "entity_type": "GENE", "pos": [4, 24]}, {"entity": "early - late viral protein", "entity_type": "GENE", "pos": [200, 226]}], "task": "NER"}
{"text": "Effects of acute exposure to cold on pulmonary arterial blood pressure in awake rats .", "entity": [], "task": "NER"}
{"text": "RNase protection analysis reveals a 10 - fold increase in the expression of SCD2 mRNA during 3T3 - L1 preadipocyte differentiation .", "entity": [{"entity": "RNase", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "SCD2 mRNA", "entity_type": "GENE", "pos": [76, 85]}], "task": "NER"}
{"text": "Spontaneous fracture of the tarsal bone in 2 cases of leprosy", "entity": [], "task": "NER"}
{"text": "CERIP interaction .", "entity": [{"entity": "CERIP", "entity_type": "GENE", "pos": [0, 5]}], "task": "NER"}
{"text": "The response sequences were localized between - 67 and + 30 in the simian cytomegalovirus IE94 promoter and upstream of position + 9 in the HCMV IE68 promoter .", "entity": [{"entity": "IE94 promoter", "entity_type": "GENE", "pos": [90, 103]}, {"entity": "HCMV IE68 promoter", "entity_type": "GENE", "pos": [140, 158]}], "task": "NER"}
{"text": "The expression of Scmh1 and rae28 / mph1 is well correlated in most tissues of embryos .", "entity": [{"entity": "Scmh1", "entity_type": "GENE", "pos": [18, 23]}, {"entity": "rae28", "entity_type": "GENE", "pos": [28, 33]}, {"entity": "mph1", "entity_type": "GENE", "pos": [36, 40]}], "task": "NER"}
{"text": "Our results suggest that it might be possible to augment IN function in vivo through a heterologous domain .", "entity": [{"entity": "IN", "entity_type": "GENE", "pos": [57, 59]}], "task": "NER"}
{"text": "Retinoic acid , which inhibits the progression of certain cancers , repressed v - src - induced MMP - 1 transcription .", "entity": [{"entity": "v - src", "entity_type": "GENE", "pos": [78, 85]}, {"entity": "MMP - 1", "entity_type": "GENE", "pos": [96, 103]}], "task": "NER"}
{"text": "Untransformed 3T3 cells carry abundant 1 . 9 kb Hox 1 . 3 RNA , whereas the methylcholanthrene - transformed MB66 and LTK - cells or 3T3 cells transformed by the oncogenes src , fos or SV40 T antigen express only low levels .", "entity": [{"entity": "Hox 1 . 3", "entity_type": "GENE", "pos": [48, 57]}, {"entity": "src", "entity_type": "GENE", "pos": [172, 175]}, {"entity": "fos", "entity_type": "GENE", "pos": [178, 181]}, {"entity": "SV40 T antigen", "entity_type": "GENE", "pos": [185, 199]}], "task": "NER"}
{"text": "Furthermore , it is also established that serine phosphorylation of STAT5a transactivation domain , via the MAPK pathway , is a means of modifying GH - induced transcriptional activation .", "entity": [{"entity": "STAT5a", "entity_type": "GENE", "pos": [68, 74]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [108, 112]}, {"entity": "GH", "entity_type": "GENE", "pos": [147, 149]}], "task": "NER"}
{"text": "Prevention of gravid Rhesus isoimmunization", "entity": [], "task": "NER"}
{"text": "Expression of medical efficiency by integration indicators with the rational utilization of budgeted funds", "entity": [], "task": "NER"}
{"text": "We infer that RecA - mediated cleavage of UmuD is another role for RecA in SOS mutagenesis , probably activating UmuD for its mutagenic function .", "entity": [{"entity": "RecA", "entity_type": "GENE", "pos": [14, 18]}, {"entity": "UmuD", "entity_type": "GENE", "pos": [42, 46]}, {"entity": "RecA", "entity_type": "GENE", "pos": [67, 71]}, {"entity": "UmuD", "entity_type": "GENE", "pos": [113, 117]}], "task": "NER"}
{"text": "Blood pressure was controlled long term ( with / without diuretics / beta - adrenoreceptor blocking drugs ) in sixteen out of nineteen patients with mild - moderate hypertension .", "entity": [{"entity": "beta - adrenoreceptor", "entity_type": "GENE", "pos": [69, 90]}], "task": "NER"}
{"text": "METHODS : Autocapture devices ( Pacesetter Microny SR + / - and Regency SR + / - ; Pacesetter , Solna , Sweden ) and steroid - eluting epicardial pacing leads ( Medtronic CapSure Epi 10366 ; Medtronic , Inc , Minneapolis , MN ) were implanted in 14 children .", "entity": [], "task": "NER"}
{"text": "This may be another example of the principle - - less is more .", "entity": [], "task": "NER"}
{"text": "The predicted amino - acid sequence includes an N - terminal signal sequence of 27 amino acids , a 27 amino - acid pro - region , a 251 amino - acid catalytic domain typical of a serine protease with trypsin - like specificity , and a C - terminal hydrophobic extension which is predicted to function as a membrane anchor .", "entity": [{"entity": "serine protease", "entity_type": "GENE", "pos": [179, 194]}, {"entity": "trypsin", "entity_type": "GENE", "pos": [200, 207]}], "task": "NER"}
{"text": "Effects of negative pi mesons on mouse bone marrow cells .", "entity": [], "task": "NER"}
{"text": "Phenotypic and molecular analyses of patients with partial chromosome 21 monosomy enabled us to define a region , spanning 2 . 4 Mb between D21S190 and D21S226 , associated with arthrogryposis , mental retardation , hypertonia , and several facial anomalies .", "entity": [{"entity": "D21S190", "entity_type": "GENE", "pos": [140, 147]}, {"entity": "D21S226", "entity_type": "GENE", "pos": [152, 159]}], "task": "NER"}
{"text": "Relation between circulating immune complexes and serum ferritin in hemosiderosis of different etiologies", "entity": [{"entity": "serum ferritin", "entity_type": "GENE", "pos": [50, 64]}], "task": "NER"}
{"text": "The zinc finger protein A20 is a tumor necrosis factor ( TNF ) - and interleukin 1 ( IL - 1 ) - inducible protein that negatively regulates nuclear factor - kappa B ( NF - kappaB ) - dependent gene expression .", "entity": [{"entity": "zinc finger protein A20", "entity_type": "GENE", "pos": [4, 27]}, {"entity": "tumor necrosis factor", "entity_type": "GENE", "pos": [33, 54]}, {"entity": "TNF", "entity_type": "GENE", "pos": [57, 60]}, {"entity": "interleukin 1", "entity_type": "GENE", "pos": [69, 82]}, {"entity": "IL - 1", "entity_type": "GENE", "pos": [85, 91]}, {"entity": "nuclear factor - kappa B", "entity_type": "GENE", "pos": [140, 164]}, {"entity": "NF - kappaB", "entity_type": "GENE", "pos": [167, 178]}], "task": "NER"}
{"text": "Treatments were two adrenocorticotrophin ( ACTH ) preparations given intramuscularly at 2 . 2 U / kg , one of the ACTH preparations given intramuscularly at 1 U / kg and a synthetic polypeptide with ACTH - like activity ( tetracosactrin , cosyntropin ) given intravenously at 5 micrograms / kg .", "entity": [{"entity": "adrenocorticotrophin", "entity_type": "GENE", "pos": [20, 40]}, {"entity": "ACTH", "entity_type": "GENE", "pos": [43, 47]}, {"entity": "ACTH", "entity_type": "GENE", "pos": [114, 118]}, {"entity": "ACTH - like", "entity_type": "GENE", "pos": [199, 210]}], "task": "NER"}
{"text": "The deviation site is equivalent to the exon 1 / exon 2 splice site of the mouse C - subunit .", "entity": [], "task": "NER"}
{"text": "The liver - specific sequence contains unique consensus sites for phosphorylation by cyclic AMP - dependent protein kinase and by protein kinase C .", "entity": [{"entity": "cyclic AMP - dependent protein kinase", "entity_type": "GENE", "pos": [85, 122]}, {"entity": "protein kinase C", "entity_type": "GENE", "pos": [130, 146]}], "task": "NER"}
{"text": "Seizure recurrence ( HR 1 . 30 ; 95 % CI = 0 . 84 , 2 . 01 ) and antiepileptic drug treatment ( HR 0 . 97 ; 95 % CI = 0 . 67 , 1 . 38 ) did not influence mortality rate .", "entity": [], "task": "NER"}
{"text": "All patients whose PSA levels reached 0 . 1 ng . / ml .", "entity": [{"entity": "PSA", "entity_type": "GENE", "pos": [19, 22]}], "task": "NER"}
{"text": "The ( 0 0 2 ) diffraction of the synthesized HAp crystals on a Col fiber showed an around 60 arching angle , while that on a ChS fiber showed just around 10 degrees .", "entity": [], "task": "NER"}
{"text": "Fas ( APO - 1 / CD95 ) , which is a member of the tumor necrosis factor receptor superfamily , is a cell surface receptor that induces apoptosis .", "entity": [{"entity": "Fas", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "APO - 1", "entity_type": "GENE", "pos": [6, 13]}, {"entity": "CD95", "entity_type": "GENE", "pos": [16, 20]}, {"entity": "tumor necrosis factor receptor superfamily", "entity_type": "GENE", "pos": [50, 92]}], "task": "NER"}
{"text": "Soft independent modelling of class analogy ( SIMCA ) is applied to identify near - infrared ( NIR ) spectra of ten excipients used in the pharmaceutical industry .", "entity": [], "task": "NER"}
{"text": "Mutations of SIN4 , ROX3 , SRB8 , SRB9 , SRB10 , SRB11 , and two novel genes , NUT1 and NUT2 , relieve the requirement of Swi4p for expression of this reporter .", "entity": [{"entity": "SIN4", "entity_type": "GENE", "pos": [13, 17]}, {"entity": "ROX3", "entity_type": "GENE", "pos": [20, 24]}, {"entity": "SRB8", "entity_type": "GENE", "pos": [27, 31]}, {"entity": "SRB9", "entity_type": "GENE", "pos": [34, 38]}, {"entity": "SRB10", "entity_type": "GENE", "pos": [41, 46]}, {"entity": "SRB11", "entity_type": "GENE", "pos": [49, 54]}, {"entity": "NUT1", "entity_type": "GENE", "pos": [79, 83]}, {"entity": "NUT2", "entity_type": "GENE", "pos": [88, 92]}, {"entity": "Swi4p", "entity_type": "GENE", "pos": [122, 127]}], "task": "NER"}
{"text": "The IB2 gene ( HGMW - approved symbol MAPK8IP2 ) maps to human chromosome 22q13 and contains 10 coding exons .", "entity": [{"entity": "IB2 gene", "entity_type": "GENE", "pos": [4, 12]}, {"entity": "MAPK8IP2", "entity_type": "GENE", "pos": [38, 46]}], "task": "NER"}
{"text": "Implantation is contraindicated for severe dysplasia of the cochlea and for the recently described variety of x - linked deafness with deficient bone at the fundus of the internal auditory meatus .", "entity": [], "task": "NER"}
{"text": "The RsmA - mutant , like its parent , produces N - ( 3 - oxohexanoyl ) - L - homoserine lactone ( HSL ) , a starvation / cell density - sensing signal required for extracellular enzyme production .", "entity": [{"entity": "RsmA - mutant", "entity_type": "GENE", "pos": [4, 17]}], "task": "NER"}
{"text": "The 101st annual meeting of the Japanese Ophthalmological Society .", "entity": [], "task": "NER"}
{"text": "The other end of this cluster contained the human type I cytokeratin K20 and K12 gene loci .", "entity": [{"entity": "human type I cytokeratin", "entity_type": "GENE", "pos": [44, 68]}, {"entity": "K20", "entity_type": "GENE", "pos": [69, 72]}, {"entity": "K12 gene", "entity_type": "GENE", "pos": [77, 85]}], "task": "NER"}
{"text": "In patients in which these criteria were not met only the reproducibility of the VO2 obtained in both the P - MET and the C - MET indicated that the maximal VO2 for these 4 patients had been reached .", "entity": [], "task": "NER"}
{"text": "In the case of the pT181 plasmid , inactivation of the initiator RepC protein occurs by the attachment of an oligonucleotide to its active tyrosine residue .", "entity": [{"entity": "initiator RepC protein", "entity_type": "GENE", "pos": [55, 77]}], "task": "NER"}
{"text": "We found multiple transcription start sites located within a 15 - base pair region , 205 base pairs upstream of the translation start codon .", "entity": [], "task": "NER"}
{"text": "Overexpression of either Sp1 or phosphorylated CREB transactivated the mCgA promoter dose dependently , while coexpression of both transcription factors resulted in an additive mCgA promoter response . mCgA - 92 to - 64 bp , comprising the Sp1 / Egr - 1 site and the CRE motif , conferred gastrin responsiveness to a heterologous thymidine kinase promoter system , and therefore functions as a \" true \" enhancer element .", "entity": [{"entity": "Sp1", "entity_type": "GENE", "pos": [25, 28]}, {"entity": "phosphorylated CREB", "entity_type": "GENE", "pos": [32, 51]}, {"entity": "mCgA promoter", "entity_type": "GENE", "pos": [71, 84]}, {"entity": "mCgA promoter", "entity_type": "GENE", "pos": [177, 190]}, {"entity": "mCgA", "entity_type": "GENE", "pos": [202, 206]}, {"entity": "Sp1", "entity_type": "GENE", "pos": [240, 243]}, {"entity": "Egr - 1", "entity_type": "GENE", "pos": [246, 253]}, {"entity": "gastrin", "entity_type": "GENE", "pos": [289, 296]}, {"entity": "heterologous thymidine kinase promoter", "entity_type": "GENE", "pos": [317, 355]}], "task": "NER"}
{"text": "Alfalfa phosphorus release kinetics showed high bacterial phosphorus contamination .", "entity": [], "task": "NER"}
{"text": "In conclusion , ORCA3 regulates jasmonate - responsive expression of the Str gene via direct interaction with the JERE .", "entity": [{"entity": "ORCA3", "entity_type": "GENE", "pos": [16, 21]}, {"entity": "Str gene", "entity_type": "GENE", "pos": [73, 81]}], "task": "NER"}
{"text": "PC12 cultures that had been \" primed \" in this way showed an accelerated and augmented differentiation response to nerve growth factor .", "entity": [{"entity": "nerve growth factor", "entity_type": "GENE", "pos": [115, 134]}], "task": "NER"}
{"text": "Pseudotumor form of pulmonary nocardia infection ( Nocardia nova ) in a renal transplant patient", "entity": [], "task": "NER"}
{"text": "Deoxyuridine - suppression test and bone marrow culture for the diagnosis of macrocytic refractory anaemias .", "entity": [], "task": "NER"}
{"text": "A computerized database of veterans discharged from the military after 1967 was selected as the source because it contains about 50 % of the total Vietnam era veteran population , is reasonably unbiased , and provides a feasible method for identifying twins .", "entity": [], "task": "NER"}
{"text": "We report that Nim1 possesses intrinsic serine - kinase , threonine - kinase and tyrosine - kinase activities .", "entity": [{"entity": "Nim1", "entity_type": "GENE", "pos": [15, 19]}, {"entity": "serine - kinase", "entity_type": "GENE", "pos": [40, 55]}, {"entity": "threonine - kinase", "entity_type": "GENE", "pos": [58, 76]}, {"entity": "tyrosine - kinase", "entity_type": "GENE", "pos": [81, 98]}], "task": "NER"}
{"text": "This mutation was associated with reduced or absent expression of TGF - beta RI protein and p53 protein in tumor tissues .", "entity": [{"entity": "TGF - beta RI protein", "entity_type": "GENE", "pos": [66, 87]}, {"entity": "p53 protein", "entity_type": "GENE", "pos": [92, 103]}], "task": "NER"}
{"text": "Keys can be used for identifying species from the European part of the USSR and north - eastern Kazakhstan .", "entity": [], "task": "NER"}
{"text": "Time between tests ( usually less than one year ) did not affect the correlations , but MMPI response - set variables ( L , F , K , F - K ) did .", "entity": [], "task": "NER"}
{"text": "Cloning and sequence analysis of a chymotrypsinlike protease from Treponema denticola .", "entity": [{"entity": "chymotrypsinlike protease from Treponema", "entity_type": "GENE", "pos": [35, 75]}], "task": "NER"}
{"text": "To initiate our analysis of factors required for eIF - 2 alpha expression , selected a CAP - proximal element shown by in vivo methylation protection analysis to bind a potential regulatory factor .", "entity": [{"entity": "eIF - 2 alpha", "entity_type": "GENE", "pos": [49, 62]}], "task": "NER"}
{"text": "The isoproterenol infusion was adjusted so that heart rate ( HR ) was at least 30 beats / min greater than baseline .", "entity": [], "task": "NER"}
{"text": "The effect of monaural middle ear destruction on postnatal development of mouse inferior colliculus .", "entity": [], "task": "NER"}
{"text": "The specificity and sensitivity of this method ( limit of detection in plasma 0 . 025 micrograms / mL and < or = 0 . 0125 micrograms / mL for febantel and its metabolites , respectively ) were sufficiently high to enable us to characterize the time course of the drug in the plasma after oral administration of therapeutic doses to sheep .", "entity": [], "task": "NER"}
{"text": "MATERIALS AND METHODS : A seven - wavelength frequency - domain photon migration probe was used to perform noninvasive NIR measurements in the breasts of 28 healthy women , both pre - and postmenopausal , aged 18 - 64 years .", "entity": [], "task": "NER"}
{"text": "Drug therapy of AAPMC is directed at reducing the amount of Cl . difficile in the colon and promoting normalization of intestinal flora .", "entity": [], "task": "NER"}
{"text": "The results of this study demonstrate that release of a single pulley after repair of the tendons in this area improved gliding excursions of the tendons and reduced resistance to motion of the repaired tendons , and provide support for partial A2 pulley incision after repair of the tendons in the area of the pulley .", "entity": [], "task": "NER"}
{"text": "The Ick protein tyrosine kinase is not involved in antibody - mediated CD4 ( CDR3 - loop ) signal transduction that inhibits HIV - 1 transcription .", "entity": [{"entity": "Ick", "entity_type": "GENE", "pos": [4, 7]}, {"entity": "protein tyrosine kinase", "entity_type": "GENE", "pos": [8, 31]}, {"entity": "CD4", "entity_type": "GENE", "pos": [71, 74]}, {"entity": "CDR3 - loop", "entity_type": "GENE", "pos": [77, 88]}], "task": "NER"}
{"text": "It is targeted to peroxisomes when expressed in mammalian cells and yeast .", "entity": [], "task": "NER"}
{"text": "Whether or not these novel repeated sequences throughout the SMA region are involved in the disease remains to be determined .", "entity": [{"entity": "SMA region", "entity_type": "GENE", "pos": [61, 71]}], "task": "NER"}
{"text": "All except the last two interventions are physical treatments that create a wound - tissue environment conducive to healing .", "entity": [], "task": "NER"}
{"text": "Consistent with our observation that AP - 1 binding does not contribute to c - Jun coactivation is the observation that the activation of PU . 1 by c - Jun is blocked by overexpression of c - Fos .", "entity": [{"entity": "AP - 1", "entity_type": "GENE", "pos": [37, 43]}, {"entity": "c - Jun", "entity_type": "GENE", "pos": [75, 82]}, {"entity": "PU . 1", "entity_type": "GENE", "pos": [138, 144]}, {"entity": "c - Jun", "entity_type": "GENE", "pos": [148, 155]}, {"entity": "c - Fos", "entity_type": "GENE", "pos": [188, 195]}], "task": "NER"}
{"text": "In a series of papers , the staging system for melanoma was critically analyzed , and many shortcomings were identified .", "entity": [], "task": "NER"}
{"text": "The transcriptional initiation site of RAG1 was localized at A , 26 bp upstream of the putative translational initiation codon , ATG , by the primer extension assay .", "entity": [{"entity": "RAG1", "entity_type": "GENE", "pos": [39, 43]}], "task": "NER"}
{"text": "The levels of products expressed from these chimeric cDNAs in COS cells were assessed by activity assay and by metabolic labeling of the proteins followed by immunoprecipitation and SDS - PAGE .", "entity": [], "task": "NER"}
{"text": "The leucine zipper region of ATF proteins is also similar to that of the AP - 1 / c - jun family of transcription factors , whose DNA - binding site differs from the ATF - binding site at a single position .", "entity": [{"entity": "ATF proteins", "entity_type": "GENE", "pos": [29, 41]}, {"entity": "AP - 1", "entity_type": "GENE", "pos": [73, 79]}, {"entity": "c - jun", "entity_type": "GENE", "pos": [82, 89]}, {"entity": "ATF", "entity_type": "GENE", "pos": [166, 169]}], "task": "NER"}
{"text": "Immunoblotting with antiphosphotyrosine antibody showed that many yeast proteins , including the p34CDC28 kinase , became phosphorylated at tyrosine in cells expressing v - src .", "entity": [{"entity": "p34CDC28 kinase", "entity_type": "GENE", "pos": [97, 112]}, {"entity": "v - src", "entity_type": "GENE", "pos": [169, 176]}], "task": "NER"}
{"text": "22 - Veneto Region )", "entity": [], "task": "NER"}
{"text": "Differential transcription of plastome - encoded genes in the mesophyll and bundle - sheath chloroplasts of the monocotyledonous NADP - malic enzyme - type C4 plants maize and Sorghum .", "entity": [{"entity": "malic enzyme", "entity_type": "GENE", "pos": [136, 148]}], "task": "NER"}
{"text": "AIMS : We postulated that perhexiline , a novel anti - ischaemic agent with an oxygen - sparing metabolic effect in the myocardium ( via inhibition of carnitine palmitoyltransferase - 1 ) and no adverse haemodynamic effects , may improve symptomatic status in elderly patients with severe aortic stenosis .", "entity": [{"entity": "carnitine palmitoyltransferase - 1", "entity_type": "GENE", "pos": [151, 185]}], "task": "NER"}
{"text": "Developmentally - regulated interaction of a transcription factor complex containing CDP / cut with the early histone H3 gene promoter of the sea urchin Tetrapygus niger is associated with changes in chromatin structure and gene expression .", "entity": [{"entity": "CDP", "entity_type": "GENE", "pos": [85, 88]}, {"entity": "cut", "entity_type": "GENE", "pos": [91, 94]}, {"entity": "early histone H3 gene promoter of the sea urchin Tetrapygus niger", "entity_type": "GENE", "pos": [104, 169]}], "task": "NER"}
{"text": "In this group of patients , the mean LH ( 9 . 3 + / - 5 . 9 IU / l ) and sex - hormone binding globulin ( SHBG ) ( 54 . 5 + / - 22 . 9 nmol / l ) concentrations were significantly greater than those of five normal control subjects ( 4 . 7 + / - 1 . 11 IU / l and 26 . 0 + / - 7 . 0 nmol / l respectively ) .", "entity": [{"entity": "LH", "entity_type": "GENE", "pos": [37, 39]}, {"entity": "sex - hormone binding globulin", "entity_type": "GENE", "pos": [73, 103]}, {"entity": "SHBG", "entity_type": "GENE", "pos": [106, 110]}], "task": "NER"}
{"text": "IRA2 , a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase - activating protein .", "entity": [{"entity": "IRA2", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "ras GTPase - activating protein", "entity_type": "GENE", "pos": [110, 141]}], "task": "NER"}
{"text": "Gastrin stimulates transcription of the human histidine decarboxylase ( HDC ) gene through binding to the G - protein - coupled cholecystokinin - B / gastrin receptor .", "entity": [{"entity": "Gastrin", "entity_type": "GENE", "pos": [0, 7]}, {"entity": "human histidine decarboxylase", "entity_type": "GENE", "pos": [40, 69]}, {"entity": "HDC", "entity_type": "GENE", "pos": [72, 75]}, {"entity": "G - protein", "entity_type": "GENE", "pos": [106, 117]}, {"entity": "cholecystokinin - B", "entity_type": "GENE", "pos": [128, 147]}, {"entity": "gastrin receptor", "entity_type": "GENE", "pos": [150, 166]}], "task": "NER"}
{"text": "RESULTS - - The maximal early asthmatic response after allergen with placebo treatment was 18 . 4 % ( SE 4 . 4 % ) and with WEB 2086 18 . 9 % ( 4 . 4 % ) .", "entity": [], "task": "NER"}
{"text": "The 3 ' region of the transcript contained a fully conserved , correctly spliced TCR alpha C region which was polyadenylated at the 3 ' end .", "entity": [{"entity": "TCR alpha C region", "entity_type": "GENE", "pos": [81, 99]}], "task": "NER"}
{"text": "Structural organization of the human Elk1 gene and its processed pseudogene Elk2 .", "entity": [{"entity": "human Elk1 gene", "entity_type": "GENE", "pos": [31, 46]}, {"entity": "pseudogene Elk2", "entity_type": "GENE", "pos": [65, 80]}], "task": "NER"}
{"text": "Results : hepatic hydatidosis : 177 patients .", "entity": [], "task": "NER"}
{"text": "Prematurely inactivating p42 MAPK in egg extracts resulted in a corresponding hastening of the first mitosis .", "entity": [{"entity": "p42 MAPK", "entity_type": "GENE", "pos": [25, 33]}], "task": "NER"}
{"text": "Anxiogenic effects of pentagastrin in patients with social phobia and healthy controls .", "entity": [], "task": "NER"}
{"text": "Dynamic expression of broad - complex isoforms mediates temporal control of an ecdysteroid target gene at the onset of Drosophila metamorphosis .", "entity": [{"entity": "broad - complex isoforms", "entity_type": "GENE", "pos": [22, 46]}], "task": "NER"}
{"text": "Identification of a putative chromosomal replication origin from Helicobacter pylori and its interaction with the initiator protein DnaA .", "entity": [{"entity": "initiator protein DnaA", "entity_type": "GENE", "pos": [114, 136]}], "task": "NER"}
{"text": "There was 91 % concordance between ST - RD / RI / LRD 201Tl and R - ST / N + Inf 99Tcm - tetrofosmin imaging regarding reversibility .", "entity": [], "task": "NER"}
{"text": "Sub - inhibitory and post - antibiotic effects of spiramycin and erythromycin on Staphylococcus aureus .", "entity": [], "task": "NER"}
{"text": "There remains the physiological problem - - one which has always been foremost in Moruzzi ' s thinking about the intrinsic regulation of brain activity - - of how the separate actions of the different arousal systems are brought together into a functional whole .", "entity": [], "task": "NER"}
{"text": "Because the variation in the carbohydrate content of human milk is very small , a more simple alternative approach would be to include only an average carbohydrate value for an estimate of energy content .", "entity": [], "task": "NER"}
{"text": "It is suggested that biliary secretion of both TBZ and FBZ and their metabolites may contribute to this recycling .", "entity": [], "task": "NER"}
{"text": "Hyperlipemia has been recently described in children with migraine , being suggested that this alteration is in the base of the disease .", "entity": [], "task": "NER"}
{"text": "BACKGROUND : A thorough understanding of malignant fibrous histiocytoma ( MFH ) , the most common subtype of soft tissue sarcoma , will lead to improved histologic - specific protocols .", "entity": [], "task": "NER"}
{"text": "The proteins encoded by these genes , called GF14 proteins , participate in protein / DNA complexes and show more than 60 % identity with a highly conserved , widely distributed protein family , collectively referred to as 14 - 3 - 3 proteins .", "entity": [{"entity": "GF14 proteins", "entity_type": "GENE", "pos": [45, 58]}, {"entity": "14 - 3 - 3", "entity_type": "GENE", "pos": [223, 233]}], "task": "NER"}
{"text": "A total of 64 uncomplicated Type - 2 diabetic individuals of higher middle class to rich socio - economic status were studied .", "entity": [], "task": "NER"}
{"text": "Using yeast two - hybrid screening , we isolated histone H3 as an interacting factor of CIA .", "entity": [{"entity": "histone H3", "entity_type": "GENE", "pos": [49, 59]}, {"entity": "CIA", "entity_type": "GENE", "pos": [88, 91]}], "task": "NER"}
{"text": "Elevated total serum calcium to a level of 11 . 9 + / - 0 . 2 mg / dl ( p less than 0 . 001 compared to control group ) developed in the gentamicin / 1 , 25 ( OH ) 2 vitamin D3 group on day 4 , 2 days prior to pronounced structural damage , and continued to be elevated through day 7 .", "entity": [], "task": "NER"}
{"text": "To investigate the role of this domain in the incorporation of the SIV Env into virions , we generated a series of SIV Env mutants carrying small in - frame deletions within the cytoplasmic domain .", "entity": [{"entity": "SIV Env", "entity_type": "GENE", "pos": [67, 74]}, {"entity": "SIV Env mutants", "entity_type": "GENE", "pos": [115, 130]}], "task": "NER"}
{"text": "Ozone uptake was assessed in awake , spontaneously breathing Fischer - 344 Sprague - Dawley , and Long - Evans rats and Hartley guinea pigs to provide data on the dosimetry of O3 in small laboratory animals .", "entity": [], "task": "NER"}
{"text": "Treatment of steroid resistant rejection following renal transplantation : benefits and risks of OKT3 therapy .", "entity": [{"entity": "OKT3", "entity_type": "GENE", "pos": [97, 101]}], "task": "NER"}
{"text": "SETTING : University research laboratory .", "entity": [], "task": "NER"}
{"text": "On the 3rd day after ischemia of the remained kidney for 30 min , structural components of the walls of the glomerular arterioles and those of the filtration - reabsorption barrier undergo certain ultrastructural changes , that with time elapsed ( 7 , 14 days ) gradually pass away , and amount of cells with hypertrophic processes increases .", "entity": [], "task": "NER"}
{"text": "Non - finger - coding modules conserved among members of subfamilies of zinc finger genes have been described in the murine genome ( finger - associated boxes , or FAX domain ) and the human genome ( Kruppel - associated boxes , or KRAB domain ) .", "entity": [{"entity": "zinc finger genes", "entity_type": "GENE", "pos": [72, 89]}, {"entity": "Kruppel - associated boxes", "entity_type": "GENE", "pos": [200, 226]}, {"entity": "KRAB domain", "entity_type": "GENE", "pos": [232, 243]}], "task": "NER"}
{"text": "Binding of C / EBPs to all three spi 2 . 3 3 ' UTR repressor sites , although rather weak , was confirmed by electrophoretic mobility shift assays that otherwise failed to reveal specific interactions with other liver nuclear proteins in vitro .", "entity": [{"entity": "C / EBPs", "entity_type": "GENE", "pos": [11, 19]}, {"entity": "spi 2 . 3 3 ' UTR repressor sites", "entity_type": "GENE", "pos": [33, 66]}], "task": "NER"}
{"text": "The newly identified NF kappa B enhancer ( TGGAAATTCC ) is bound by a TNF alpha - induced nuclear protein and appears to be the key element in rapid transcription induction by TNF alpha ( and TPA ) , while transactivation of this element is repressed by the ligand - bound glucocorticoid receptor .", "entity": [{"entity": "NF kappa B enhancer", "entity_type": "GENE", "pos": [21, 40]}, {"entity": "TNF alpha", "entity_type": "GENE", "pos": [70, 79]}, {"entity": "TNF alpha", "entity_type": "GENE", "pos": [176, 185]}, {"entity": "glucocorticoid receptor", "entity_type": "GENE", "pos": [273, 296]}], "task": "NER"}
{"text": "Despite the fact that biochemical estimates of bone turnover indicate that ( short - term ) administration of rhGH and IGF - I stimulates bone metabolism in non - osteoporotic older people , no significant changes have been observed in bone mineral density at the proximal femur .", "entity": [{"entity": "rhGH", "entity_type": "GENE", "pos": [110, 114]}, {"entity": "IGF - I", "entity_type": "GENE", "pos": [119, 126]}], "task": "NER"}
{"text": "Parental and vector - transfected MCF7 cells , which were sensitive to the growth - inhibitory effects of atRA , exhibited atRA - dependent retinoic acid receptor ( RAR ) transactivation and transrepression of 12 - O - tetradecanoylphorbol - 13 - acetate - induced AP - 1 activity .", "entity": [{"entity": "retinoic acid receptor", "entity_type": "GENE", "pos": [140, 162]}, {"entity": "RAR", "entity_type": "GENE", "pos": [165, 168]}, {"entity": "AP - 1", "entity_type": "GENE", "pos": [265, 271]}], "task": "NER"}
{"text": "Chemiluminescence induced by opsonized zymosan increased significantly ( P less than 0 . 05 ) after treatment with bacterial extracts , whereas no significant changes were observed in the fMLP - stimulated PMNs .", "entity": [], "task": "NER"}
{"text": "Using the two - hybrid screening method , we have identified an additional component of the CCAAT - binding factor .", "entity": [{"entity": "CCAAT - binding factor", "entity_type": "GENE", "pos": [92, 114]}], "task": "NER"}
{"text": "Our studies suggest that the helicase assembly protein is responsible for loading T4 gene 41 helicase specifically at replication forks , and that its binding sites for each arm must hold more than six , but not more than 12 nucleotides .", "entity": [{"entity": "helicase", "entity_type": "GENE", "pos": [29, 37]}, {"entity": "T4 gene 41 helicase", "entity_type": "GENE", "pos": [82, 101]}], "task": "NER"}
{"text": "These results strongly suggest that HSV - 1 infection inhibits host cell splicing through the action of ICP27 .", "entity": [{"entity": "ICP27", "entity_type": "GENE", "pos": [104, 109]}], "task": "NER"}
{"text": "Sci .", "entity": [], "task": "NER"}
{"text": "In our initial studies , we treated MCF - 7 cells with paclitaxel , which results in the arrest of cells in G1 with 4n DNA content ( pseudo G1 ) .", "entity": [], "task": "NER"}
{"text": "A GTP / GDP exchange assay was used to assess the potential role of Ras in the pathway leading to ERK phosphorylation ; DADLE failed to stimulate GTP / GDP exchange in comparison to PMA .", "entity": [{"entity": "Ras", "entity_type": "GENE", "pos": [68, 71]}, {"entity": "ERK", "entity_type": "GENE", "pos": [98, 101]}], "task": "NER"}
{"text": "The primary structures of the human KB cell ( FR - KB1 ) folate receptor ( FR ) and of a human placental ( FR - P2 ) FR , proteins important in cellular accumulation of folates , have been deduced from cDNA sequences .", "entity": [{"entity": "human KB cell ( FR - KB1 ) folate receptor", "entity_type": "GENE", "pos": [30, 72]}, {"entity": "FR", "entity_type": "GENE", "pos": [75, 77]}, {"entity": "human placental ( FR - P2 ) FR", "entity_type": "GENE", "pos": [89, 119]}], "task": "NER"}
{"text": "Possible or definite neglect or abuse before 36 months of age was correlated with low DBH activity .", "entity": [{"entity": "DBH", "entity_type": "GENE", "pos": [86, 89]}], "task": "NER"}
{"text": "The remaining 77 nucleotides at the 3 ' end of domain II and all of domains III ( 655 nucleotides ) and IV ( 770 nucleotides ) are not present in DIssE RNA .", "entity": [{"entity": "DIssE RNA", "entity_type": "GENE", "pos": [146, 155]}], "task": "NER"}
{"text": "Changes in tension were monitored isometrically on spiral strips of freshly obtained bovine basilar arteries .", "entity": [], "task": "NER"}
{"text": "The preparative regimen consisted of fractionated total body irradiation ( TBI ) and cyclophosphamide ( CY ) .", "entity": [], "task": "NER"}
{"text": "The dynamics of protozoa were studied in two groups of rumen - fistulated cattle fed on a basal diet of molasses ad lib . , with oaten chaff given at 6 or 18 g / kg live weight .", "entity": [], "task": "NER"}
{"text": "Consistent with the large pocket of Rb binding to TAF ( II ) 250 , the large pocket domains of both p107 and p130 are able to bind to TAF ( II ) 250 in vivo .", "entity": [{"entity": "Rb", "entity_type": "GENE", "pos": [36, 38]}, {"entity": "TAF ( II ) 250", "entity_type": "GENE", "pos": [50, 64]}, {"entity": "p107", "entity_type": "GENE", "pos": [100, 104]}, {"entity": "p130", "entity_type": "GENE", "pos": [109, 113]}, {"entity": "TAF ( II ) 250", "entity_type": "GENE", "pos": [134, 148]}], "task": "NER"}
{"text": "Patients with Eales ' disease , chorioretinitis , central serous retinopathy , or malignant choroidal melanoma were tested for HLA antigen deviation .", "entity": [{"entity": "HLA", "entity_type": "GENE", "pos": [127, 130]}], "task": "NER"}
{"text": "Comparison of the derived amino acid sequence with that of the HCMV UL99 gene product reveals 34 . 8 % identity in an overlap of 66 amino acids .", "entity": [{"entity": "HCMV UL99 gene product", "entity_type": "GENE", "pos": [63, 85]}], "task": "NER"}
{"text": "White female cases were more likely to have worked as registered nurses than were the controls ( OR = 1 . 9 , 95 % CI = 1 . 0 - 3 . 5 ) .", "entity": [], "task": "NER"}
{"text": "Fentanyl citrate ( 0 . 1 mL ) and 2H5 - fentanyl ( internal standard , 0 . 05 mL , 100 mg / L ) were extracted with Toxi - A tubes ( Toxi - Lab , Irvine , CA ) and analyzed by gas chromatography - mass spectrometry .", "entity": [], "task": "NER"}
{"text": "O5257 shows homology with the SAS2 protein and another hypothetical protein from yeast .", "entity": [{"entity": "O5257", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "SAS2 protein", "entity_type": "GENE", "pos": [30, 42]}], "task": "NER"}
{"text": "Cotransfection of expression plasmids encoding the protein kinase A inhibitor , or an inactive protein kinase A ( PKA ) catalytic beta subunit , inhibited both forskolin and PACAP activation of chromogranin A transcription , revealing that PACAP - induced trans - activation is highly dependent on PKA .", "entity": [{"entity": "protein kinase A", "entity_type": "GENE", "pos": [51, 67]}, {"entity": "protein kinase A", "entity_type": "GENE", "pos": [95, 111]}, {"entity": "PKA", "entity_type": "GENE", "pos": [114, 117]}, {"entity": "PACAP", "entity_type": "GENE", "pos": [174, 179]}, {"entity": "chromogranin A", "entity_type": "GENE", "pos": [194, 208]}, {"entity": "PACAP", "entity_type": "GENE", "pos": [240, 245]}, {"entity": "PKA", "entity_type": "GENE", "pos": [298, 301]}], "task": "NER"}
{"text": "Of all YASR syndromes , the highest stability was for the Anxious / Depressed scale .", "entity": [], "task": "NER"}
{"text": "There was no difference in serum albumin and transferrin levels , but serum prealbumin levels in the group fed early were more desirable than those of the control group ( from 15 . 8 + / - 2 . 5 mg / dl to 28 . 9 + / - 3 . 8 mg / dl vs from 18 . 0 + / - 2 . 0 mg / dl to 25 . 9 + / - 3 . 9 mg / dl ) .", "entity": [{"entity": "serum albumin", "entity_type": "GENE", "pos": [27, 40]}, {"entity": "transferrin", "entity_type": "GENE", "pos": [45, 56]}, {"entity": "serum prealbumin", "entity_type": "GENE", "pos": [70, 86]}], "task": "NER"}
{"text": "The introduction gives also the history of Research Programme MZ - XVII and its implementation in several regions of Poland .", "entity": [], "task": "NER"}
{"text": "The uap100 cis - acting , up - promoter , constitutive mutation is a duplication that comprises two GATA sites and suppresses weakly the AREA zinc finger mutation but does not alleviate the need for functional UAY and AREA proteins .", "entity": [{"entity": "uap100", "entity_type": "GENE", "pos": [4, 10]}, {"entity": "AREA zinc finger mutation", "entity_type": "GENE", "pos": [137, 162]}, {"entity": "UAY", "entity_type": "GENE", "pos": [210, 213]}, {"entity": "AREA proteins", "entity_type": "GENE", "pos": [218, 231]}], "task": "NER"}
{"text": "Significant differences were observed in the composition of nuclear transcription factors bound to cis - elements within the LDH / C proximal promoter region in somatic versus germ cells .", "entity": [{"entity": "LDH / C proximal promoter region", "entity_type": "GENE", "pos": [125, 157]}], "task": "NER"}
{"text": "We conclude that although the G3 sequence contains two protein - binding motifs , the organization of the G3 enhancer - like element is not bipartite .", "entity": [], "task": "NER"}
{"text": "With BCPP protocol , 12 achieved a complete response , 11 evidenced a 75 % response , and 7 displayed a 50 % response .", "entity": [], "task": "NER"}
{"text": "The effects of tilmicosin administration in the feed at 400 mg / kg and an injection therapy of clinically diseased pigs with long - acting oxytetracycline ( Terramycine LA ) at 20 mg / kg bodyweight were compared .", "entity": [], "task": "NER"}
{"text": "In 7 men and 1 woman who died suddenly the functionally important areas of myocardium in the sino - auricular area and the subendocardial layers of left ventricle were obtained by necropsy no more than 3 h after death , and then prepared for study by electron microscopy .", "entity": [], "task": "NER"}
{"text": "Importantly , a single base change in the fifth position of the c - fos sequence ( GGTCTnnnAGACC to GGTCA / GnnnAGACC ) produced an element that bound the estrogen receptor and conferred estrogen - dependent transcriptional activation of a reporter gene .", "entity": [{"entity": "c - fos sequence", "entity_type": "GENE", "pos": [64, 80]}, {"entity": "estrogen receptor", "entity_type": "GENE", "pos": [155, 172]}], "task": "NER"}
{"text": "A preterm formula with a traditional corn oil / MCT blend containing 38 % MCTs ( MCT group ) was compared to a new fat blend , designed to resemble human milk more , containing 6 % MCTs ( LCT group ) .", "entity": [], "task": "NER"}
{"text": "The existence of a TFIIIB assembly pathway leading to the faithful transcription of natural eukaryotic tRNA genes in the absence of TFIIIC provides novel insights into the functional flexibility of the eukaryotic tRNA gene transcription machinery and on its evolution from an ancestral RNA polymerase III system relying on upstream , TATA - centered control elements .", "entity": [{"entity": "TFIIIB", "entity_type": "GENE", "pos": [19, 25]}, {"entity": "TFIIIC", "entity_type": "GENE", "pos": [132, 138]}, {"entity": "RNA polymerase III", "entity_type": "GENE", "pos": [286, 304]}], "task": "NER"}
{"text": "Overexpression of N - terminal mutations disturbs mitosis and produces elongated cells , Using a PCR approach , we isolated a putative homologue of Prp4 from human and mouse cells .", "entity": [{"entity": "Prp4", "entity_type": "GENE", "pos": [148, 152]}], "task": "NER"}
{"text": "Successive 5 ' deletions of the [ - 326 ; + 20 ] type II sPLA2 promoter indicated that the region upstream of position - 195 inhibits the transcription activity sixfold in HepG2 cells but not in HeLa cells .", "entity": [{"entity": "type II sPLA2 promoter", "entity_type": "GENE", "pos": [49, 71]}], "task": "NER"}
{"text": "Pyridostigmine pretreatment was supplemented by therapy with two doses of an antidotal combination ( A , TM , B ) consisting of 0 . 05 mg / kg atropine , 2 . 24 mg / kg TMB - 4 , and 0 . 4 mg / kg benactyzine which assured survival in five of six animals following three separate exposures to 10 LD50 soman .", "entity": [], "task": "NER"}
{"text": "Electrophoretic mobility shift assays and DNase I protection analyses revealed that FP I was bound by the transcription factor PU . 1 / Spi - 1 .", "entity": [{"entity": "DNase I", "entity_type": "GENE", "pos": [42, 49]}, {"entity": "FP I", "entity_type": "GENE", "pos": [84, 88]}, {"entity": "PU . 1", "entity_type": "GENE", "pos": [127, 133]}, {"entity": "Spi - 1", "entity_type": "GENE", "pos": [136, 143]}], "task": "NER"}
{"text": "Moreover , the noncoordinate effects of FSK on PMA - stimulated MKK and MAPK activities indicates the presence of a additional distal cAMP - dependent inhibitory mechanisms .", "entity": [{"entity": "FSK", "entity_type": "GENE", "pos": [40, 43]}, {"entity": "MKK", "entity_type": "GENE", "pos": [64, 67]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [72, 76]}], "task": "NER"}
{"text": "Motilin serum levels were measured for one hour .", "entity": [{"entity": "Motilin", "entity_type": "GENE", "pos": [0, 7]}], "task": "NER"}
{"text": "Parameters of sperm quality were evaluated before and after freezing / thawing .", "entity": [], "task": "NER"}
{"text": "Comment on \" Critical behavior of a binary mixture of protein and salt water \"", "entity": [], "task": "NER"}
{"text": "Site - directed mutagenesis was conducted to investigate the functional significance of this element and the 3 ' minus - strand terminal sequence \" 3 ' - OH - CCCUAU , \" which contains the minus - strand 3 ' - end sequence \" 3 ' - OH - CC ( 1 - 2 ) ( A / U ) ( A / U ) ( A / U ) \" found in all carmovirus RNAs .", "entity": [], "task": "NER"}
{"text": "Characterization of a nuclear deformed epidermal autoregulatory factor - 1 ( DEAF - 1 ) - related ( NUDR ) transcriptional regulator protein .", "entity": [{"entity": "nuclear deformed epidermal autoregulatory factor - 1", "entity_type": "GENE", "pos": [22, 74]}, {"entity": "DEAF - 1", "entity_type": "GENE", "pos": [77, 85]}, {"entity": "NUDR", "entity_type": "GENE", "pos": [100, 104]}], "task": "NER"}
{"text": "Cardiac lesion in exotoxic shock", "entity": [], "task": "NER"}
{"text": "Effect of family visits on the blood pressure and heart rate of patients in the coronary - care unit .", "entity": [], "task": "NER"}
{"text": "Prospects of chemosterilant and genetic control of rodents .", "entity": [], "task": "NER"}
{"text": "Neurological toxicity occurred in 8 / 219 patients treated with fludarabine ( FAMP ) , 30 mg / m2 per day and cytosine arabinoside ( Ara - C ) , 0 . 5 g / m2 per hour for 2 - 6 hours for 5 days , for new or relapsed acute leukemia or myelodysplasia .", "entity": [], "task": "NER"}
{"text": "Ondansetron is thus an effective first - line antiemetic in children undergoing chemotherapy , radiotherapy and surgery .", "entity": [], "task": "NER"}
{"text": "Paclitaxel caused a rapid and transient increase in c - Jun NH2 - terminal kinase ( JNK ) activity , a proposed mediator of stress activation pathways .", "entity": [{"entity": "c - Jun NH2 - terminal kinase", "entity_type": "GENE", "pos": [52, 81]}, {"entity": "JNK", "entity_type": "GENE", "pos": [84, 87]}], "task": "NER"}
{"text": "Aspirin therapy in the rheumatic diseases .", "entity": [], "task": "NER"}
{"text": "High - level expression of sccypB as well as of sccypA cloned into the expression vector pIJ702 did not produce detectable changes in growth and morphology of S . chrysomallus and S . lividans .", "entity": [{"entity": "sccypB", "entity_type": "GENE", "pos": [27, 33]}, {"entity": "sccypA", "entity_type": "GENE", "pos": [48, 54]}], "task": "NER"}
{"text": "Reasons are presented to support the contention that this increase is in part real .", "entity": [], "task": "NER"}
{"text": "Expression of the Hox genes egl - 5 and mab - 5 is reduced in lin - 49 and lin - 59 mutants , suggesting lin - 49 and lin - 59 regulate HOM - C gene expression in C . elegans as the trx - G genes do in Drosophila . lin - 49 and lin - 59 transgenes are expressed widely throughout C . elegans animals .", "entity": [{"entity": "Hox genes", "entity_type": "GENE", "pos": [18, 27]}, {"entity": "egl - 5", "entity_type": "GENE", "pos": [28, 35]}, {"entity": "mab - 5", "entity_type": "GENE", "pos": [40, 47]}, {"entity": "lin - 49", "entity_type": "GENE", "pos": [62, 70]}, {"entity": "lin - 59 mutants", "entity_type": "GENE", "pos": [75, 91]}, {"entity": "lin - 49", "entity_type": "GENE", "pos": [105, 113]}, {"entity": "lin - 59", "entity_type": "GENE", "pos": [118, 126]}, {"entity": "HOM - C gene", "entity_type": "GENE", "pos": [136, 148]}, {"entity": "trx - G genes", "entity_type": "GENE", "pos": [182, 195]}, {"entity": "lin - 49", "entity_type": "GENE", "pos": [215, 223]}, {"entity": "lin - 59 transgenes", "entity_type": "GENE", "pos": [228, 247]}], "task": "NER"}
{"text": "In cotransfection assays , a small fragment of Sin retaining the Src - SH3 - binding site and one tyrosine - containing motif induced c - Src activation as measured by a transcriptional reporter .", "entity": [{"entity": "Sin", "entity_type": "GENE", "pos": [47, 50]}, {"entity": "Src", "entity_type": "GENE", "pos": [65, 68]}, {"entity": "SH3", "entity_type": "GENE", "pos": [71, 74]}, {"entity": "c - Src", "entity_type": "GENE", "pos": [134, 141]}], "task": "NER"}
{"text": "TFIIB and VDR can also interact directly , and these factors synergize to mediate transactivation .", "entity": [{"entity": "TFIIB", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "VDR", "entity_type": "GENE", "pos": [10, 13]}], "task": "NER"}
{"text": "In addition , 269 mice from a ( Mus spretus x C57BL / 6J ) F1 x C57BL / 6J interspecific backcross were also used to order marker loci and calculate intergene distances for this region .", "entity": [], "task": "NER"}
{"text": "Our findings suggest that AIF may be a morphologic correlate of tumor regression following preoperative cytotoxic chemotherapy .", "entity": [], "task": "NER"}
{"text": "Hypocalcemia is usually due to either a disturbance in the parathyroid hormone - adenylate cyclase system or a disturbance in vitamin D metabolism .", "entity": [{"entity": "parathyroid hormone", "entity_type": "GENE", "pos": [59, 78]}, {"entity": "adenylate cyclase", "entity_type": "GENE", "pos": [81, 98]}], "task": "NER"}
{"text": "The system consists of a TV unit compatible to IBM PC / AT and software .", "entity": [], "task": "NER"}
{"text": "Newly hatched F1 nymphs of Aiolopus thalassinus ( Fabr . ) were fed on food treated with various concentrations of HgCl2 , CdCl2 , and PbCl2 until the end of adult life .", "entity": [], "task": "NER"}
{"text": "Reduced concentrations of antithrombin III , plasminogen , ( free ) protein S , and protein C were found in some patients but were not associated with either thrombosis or lupus anticoagulant .", "entity": [{"entity": "antithrombin III", "entity_type": "GENE", "pos": [26, 42]}, {"entity": "plasminogen", "entity_type": "GENE", "pos": [45, 56]}, {"entity": "protein S", "entity_type": "GENE", "pos": [68, 77]}, {"entity": "protein C", "entity_type": "GENE", "pos": [84, 93]}], "task": "NER"}
{"text": "UICC criteria ) for VM and 35 % for VE ( not significant ) .", "entity": [], "task": "NER"}
{"text": "Simvastatin decreased levels of total cholesterol by 20 . 8 % , LDL cholesterol by 29 . 7 % , triglycerides by 13 . 6 % , apolipoprotein B by 22 . 4 % , alpha - tocopherol by 16 . 2 % , beta - carotene by 19 . 5 % , and ubiquinol - 10 by 22 . 0 % ( P < . 001 for all ) and increased levels of HDL cholesterol by 7 . 0 % ( P < . 001 ) and serum insulin by 13 . 2 % ( P = . 005 ) .", "entity": [{"entity": "LDL cholesterol", "entity_type": "GENE", "pos": [64, 79]}, {"entity": "apolipoprotein B", "entity_type": "GENE", "pos": [122, 138]}, {"entity": "HDL cholesterol", "entity_type": "GENE", "pos": [293, 308]}, {"entity": "serum insulin", "entity_type": "GENE", "pos": [338, 351]}], "task": "NER"}
{"text": "Ultrasonography is a diagnostic alternative which may replace arthrography .", "entity": [], "task": "NER"}
{"text": "Northern blot analysis with GPR37 probes revealed a main 3 . 8 - kb mRNA and a less abundant 8 - kb mRNA , both expressed in human brain tissues , particularly in corpus callosum , medulla , putamen , and caudate nucleus .", "entity": [{"entity": "GPR37", "entity_type": "GENE", "pos": [28, 33]}], "task": "NER"}
{"text": "TNF - alpha effect was eliminated by a 2 - bp substitution mutation in the NF - kappa B1 binding half site of the NF - kappa B cis element .", "entity": [{"entity": "TNF - alpha", "entity_type": "GENE", "pos": [0, 11]}, {"entity": "NF - kappa B1 binding half site", "entity_type": "GENE", "pos": [75, 106]}, {"entity": "NF - kappa B cis element", "entity_type": "GENE", "pos": [114, 138]}], "task": "NER"}
{"text": "Three RasV12 mutants ( S35 , G37 , and C40 ) which differ by their ability to bind to Ras effectors ( Raf , Ral - GEFs , and the p110 subunit of PI 3 - kinase , respectively ) were able to induce sustained NR cell proliferation , although none of these mutants was reported to transform NIH 3T3 cells .", "entity": [{"entity": "RasV12 mutants", "entity_type": "GENE", "pos": [6, 20]}, {"entity": "S35", "entity_type": "GENE", "pos": [23, 26]}, {"entity": "G37", "entity_type": "GENE", "pos": [29, 32]}, {"entity": "C40", "entity_type": "GENE", "pos": [39, 42]}, {"entity": "Ras effectors", "entity_type": "GENE", "pos": [86, 99]}, {"entity": "Raf", "entity_type": "GENE", "pos": [102, 105]}, {"entity": "Ral - GEFs", "entity_type": "GENE", "pos": [108, 118]}, {"entity": "p110 subunit of PI 3 - kinase", "entity_type": "GENE", "pos": [129, 158]}], "task": "NER"}
{"text": "A possible correlation between mandibular growth retardation and palatal clefting is discussed .", "entity": [], "task": "NER"}
{"text": "Total cross sections for electron scattering by CO2 molecules in the energy range 400 - 5000 eV .", "entity": [], "task": "NER"}
{"text": "However , depending upon the promoter context , we observed cooperative interactions between the two domains to confer high DNA - binding affinity and specificity .", "entity": [], "task": "NER"}
{"text": "RESEARCH DESIGN AND METHODS : A total of 26 IDDM patients with normoalbuminuria were randomized into two groups , with one group receiving placebo ( n = 13 , age 36 + / - 3 years , BMI 24 . 5 + / - 1 . 1 kg / m2 ) and the other group receiving an average of 15 mg lisinopril daily ( n = 13 , age 34 + / - 2 years , BMI 24 . 4 + / - 0 . 9 kg / m2 ) .", "entity": [], "task": "NER"}
{"text": "This experience would recommend consideration of home nutritional support in patients with systemic scleroderma when the disease is relatively stable and no major organ failure is present .", "entity": [], "task": "NER"}
{"text": "Adult - onset parkinsonism has appeared in several previously unaffected members in families with DRD suggesting that this may be an additional phenotypical expression of the disease .", "entity": [], "task": "NER"}
{"text": "Production of VT was also examined retrospectively in 32 E . coli strains of serotype O26 : H11 isolated from children with diarrhoea ; eight ( 25 % ) of them produced moderate to high levels of verotoxin 1 despite several years storage in vitro .", "entity": [{"entity": "verotoxin 1", "entity_type": "GENE", "pos": [195, 206]}], "task": "NER"}
{"text": "The present study deals with the screening of 11 of these plants against the opportunistic pathogen fungus Candida albicans .", "entity": [], "task": "NER"}
{"text": "The tam A gene of Aspergillus nidulans encodes a 739 - amino acid protein with similarity to Uga35p / Dal81p / DurLp of Saccharomyces cerevisiae .", "entity": [{"entity": "tam A gene of Aspergillus nidulans", "entity_type": "GENE", "pos": [4, 38]}, {"entity": "Uga35p", "entity_type": "GENE", "pos": [93, 99]}, {"entity": "Dal81p", "entity_type": "GENE", "pos": [102, 108]}, {"entity": "DurLp", "entity_type": "GENE", "pos": [111, 116]}], "task": "NER"}
{"text": "The 5 ' - flanking region of the gene , approximately 1 . 1 kbp long , had no known regulatory elements for transcription such as TATA , GC , and CCAAT boxes .", "entity": [], "task": "NER"}
{"text": "The Molteno implant is an effective procedure in the treatment of complicated and refractory cases of glaucoma in high - risk eyes .", "entity": [], "task": "NER"}
{"text": "Two of the three groups were submitted to two different levels of hypoxia ( FiO2 = 0 . 05 , group F5 and FiO2 = 0 . 1 , group F10 ) and the third to normoxia ( FiO2 = 0 . 21 , group F21 ) in a thermoneutral and controlled environment .", "entity": [], "task": "NER"}
{"text": "Glutathione reductase ( GR ) was purified from the cyanobacterium Anabaena PCC 7120 .", "entity": [{"entity": "Glutathione reductase", "entity_type": "GENE", "pos": [0, 21]}, {"entity": "GR", "entity_type": "GENE", "pos": [24, 26]}], "task": "NER"}
{"text": "Genotype - phenotype correlations in male patients with a partial nullisomy of the X chromosome have suggested that at least one locus involved in MRX is on Xp22 . 3 .", "entity": [], "task": "NER"}
{"text": "On the other hand , NE transport and antagonist ( [ 125I ] RTI - 55 ) binding assays on whole LLC - NET cells treated with tunicamycin reveal a pronounced reduction in NE transport activity and hNET membrane density paralleled by an inability of NET proteins to replenish the higher M ( r ) hNET pool .", "entity": [{"entity": "hNET", "entity_type": "GENE", "pos": [194, 198]}, {"entity": "NET proteins", "entity_type": "GENE", "pos": [246, 258]}, {"entity": "hNET", "entity_type": "GENE", "pos": [291, 295]}], "task": "NER"}
{"text": "We have now completed the primary structure of fibrillin , elucidated the exon / intron organization of the gene and derived a physical map of the genetic locus .", "entity": [{"entity": "fibrillin", "entity_type": "GENE", "pos": [47, 56]}], "task": "NER"}
{"text": "The deduced amino acid sequence of PutR ( 154 amino acid residues ) showed homology to the small regulatory proteins Lrp , BkdR , and AsnC .", "entity": [{"entity": "PutR", "entity_type": "GENE", "pos": [35, 39]}, {"entity": "Lrp", "entity_type": "GENE", "pos": [117, 120]}, {"entity": "BkdR", "entity_type": "GENE", "pos": [123, 127]}, {"entity": "AsnC", "entity_type": "GENE", "pos": [134, 138]}], "task": "NER"}
{"text": "NF - kappaB only partially mediates Epstein - Barr virus latent membrane protein 1 activation of B cells .", "entity": [{"entity": "NF - kappaB", "entity_type": "GENE", "pos": [0, 11]}, {"entity": "Epstein - Barr virus latent membrane protein 1", "entity_type": "GENE", "pos": [36, 82]}], "task": "NER"}
{"text": "In contrast , stem - loop structures 2 , 3 , and 4 of the 3 ' domain showed great variations in size , sequence , and structure .", "entity": [], "task": "NER"}
{"text": "Whereas Sprague - Dawleys displayed lights - off and lights - on peaks of ingestive activity , only a minority of Fisher - 344s displayed a consistent lights - on peak of ingestive activity .", "entity": [], "task": "NER"}
{"text": "The mammalian UPR is mediated by the cis - acting ER stress response element consisting of 19 nt ( CCAATN ( 9 ) CCACG ) , the CCACG part of which is considered to provide specificity .", "entity": [], "task": "NER"}
{"text": "Effects of dietary lipids on whole - body retention and organ distribution of organic and inorganic mercury in mice .", "entity": [], "task": "NER"}
{"text": "This region shows 46 % identity with the calmodulin - binding region of rat brain Ca2 + / calmodulin - dependent protein kinase II and 32 % identity with the equivalent region of chicken smooth muscle myosin light chain kinase .", "entity": [{"entity": "calmodulin - binding region", "entity_type": "GENE", "pos": [41, 68]}, {"entity": "rat brain Ca2 + / calmodulin - dependent protein kinase II", "entity_type": "GENE", "pos": [72, 130]}, {"entity": "chicken smooth muscle myosin light chain kinase", "entity_type": "GENE", "pos": [179, 226]}], "task": "NER"}
{"text": "1H and 15N magnetic resonance assignments , secondary structure , and tertiary fold of Escherichia coli DnaJ ( 1 - 78 ) .", "entity": [{"entity": "Escherichia coli DnaJ ( 1 - 78 )", "entity_type": "GENE", "pos": [87, 119]}], "task": "NER"}
{"text": "The effects of inoculum size , medium , temperature , and duration of growth on the in vitro susceptibility testing of Aspergillus fumigatus were investigated using broth micro - and macro - dilution techniques .", "entity": [], "task": "NER"}
{"text": "This dynamic nature may be relevant to the ability of E47 both to homodimerize and to heterodimerize with MyoD , Id , and Tal1 .", "entity": [{"entity": "E47", "entity_type": "GENE", "pos": [54, 57]}, {"entity": "MyoD", "entity_type": "GENE", "pos": [106, 110]}, {"entity": "Id", "entity_type": "GENE", "pos": [113, 115]}, {"entity": "Tal1", "entity_type": "GENE", "pos": [122, 126]}], "task": "NER"}
{"text": "We identified clones of Chlamydomonas genomic DNA that rescued the Ca ( 2 + ) - dependent axonemal microtubule severing defect of fa1 mutants .", "entity": [{"entity": "fa1 mutants", "entity_type": "GENE", "pos": [130, 141]}], "task": "NER"}
{"text": "STUDY SELECTION : Not applicable .", "entity": [], "task": "NER"}
{"text": "Sequence and deletion analysis of the recombination enhancement gene ( ref ) of bacteriophage P1 : evidence for promoter - operator and attenuator - antiterminator control .", "entity": [{"entity": "recombination enhancement gene", "entity_type": "GENE", "pos": [38, 68]}, {"entity": "ref", "entity_type": "GENE", "pos": [71, 74]}], "task": "NER"}
{"text": "Viral protein U ( Vpu ) is a protein encoded by human immunodeficiency virus type 1 ( HIV - 1 ) that promotes the degradation of the virus receptor , CD4 , and enhances the release of virus particles from cells .", "entity": [{"entity": "Viral protein U", "entity_type": "GENE", "pos": [0, 15]}, {"entity": "Vpu", "entity_type": "GENE", "pos": [18, 21]}, {"entity": "CD4", "entity_type": "GENE", "pos": [150, 153]}], "task": "NER"}
{"text": "There also may be osmotic challenges to mucosal cell function as evidenced by the different reaction rates with hyper - and hypotonic saline .", "entity": [], "task": "NER"}
{"text": "The overall objective response rate ( RR ) was 50 % [ 95 % confidence interval ( CI ) = 29 - 71 % ] including four complete responses and eight partial responses .", "entity": [], "task": "NER"}
{"text": "In spite of the variability of DD95 with regard to body weight , the recovery of neuromuscular transmission in the patients of the three groups is comparable .", "entity": [], "task": "NER"}
{"text": "SH3A competes with the SH3 domains of Grb2 in binding to mSos1 , and the intersectin - mSos1 complex can be separated from Grb2 by sucrose gradient centrifugation .", "entity": [{"entity": "SH3A", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "SH3 domains", "entity_type": "GENE", "pos": [23, 34]}, {"entity": "Grb2", "entity_type": "GENE", "pos": [38, 42]}, {"entity": "mSos1", "entity_type": "GENE", "pos": [57, 62]}, {"entity": "intersectin", "entity_type": "GENE", "pos": [73, 84]}, {"entity": "mSos1", "entity_type": "GENE", "pos": [87, 92]}, {"entity": "Grb2", "entity_type": "GENE", "pos": [123, 127]}], "task": "NER"}
{"text": "Both oligonucleotide cross - competition and antibody supershift experiments established that the double - strand binding protein is equivalent to Sp1 .", "entity": [{"entity": "Sp1", "entity_type": "GENE", "pos": [147, 150]}], "task": "NER"}
{"text": "The major transcription start site , designated as + 1 , was determined by RACE ( rapid amplification of cDNA ends ) analysis of human liver cDNA and was found to be located 50 bp upstream from the translation start site .", "entity": [], "task": "NER"}
{"text": "Kerstin takes the abbreviated medical education .", "entity": [], "task": "NER"}
{"text": "Epithelial cells had abnormal and accelerated exfoliation which resulted in multifocal epithelial defects .", "entity": [], "task": "NER"}
{"text": "Influenza virus - induced NF - kappaB - dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IkappaB kinase .", "entity": [{"entity": "NF - kappaB - dependent gene", "entity_type": "GENE", "pos": [26, 54]}, {"entity": "IkappaB kinase", "entity_type": "GENE", "pos": [164, 178]}], "task": "NER"}
{"text": "The Xenopus annexin II heavy chain lacks the highly conserved tyrosine at position 23 which is the site of src oncogene tyrosine kinase phosphorylation in the murine protein .", "entity": [{"entity": "Xenopus annexin II heavy chain", "entity_type": "GENE", "pos": [4, 34]}, {"entity": "src oncogene", "entity_type": "GENE", "pos": [107, 119]}, {"entity": "tyrosine kinase", "entity_type": "GENE", "pos": [120, 135]}], "task": "NER"}
{"text": "This demonstrates a relative independence of the given synchronizer of rhythmicity at a tissue level from any influence of the higher regulatory center .", "entity": [], "task": "NER"}
{"text": "Two of the proteins UPRF - 1 and UPRF - 2 ( which is apparently a proteolytic degradation product of UPRF - 1 ) bind inefficiently to mutant versions of the UPR that are unable to confer responsiveness to unfolded proteins to the ( CYC1 ) promoter .", "entity": [{"entity": "UPRF - 1", "entity_type": "GENE", "pos": [20, 28]}, {"entity": "UPRF - 2", "entity_type": "GENE", "pos": [33, 41]}, {"entity": "UPRF - 1", "entity_type": "GENE", "pos": [101, 109]}, {"entity": "CYC1", "entity_type": "GENE", "pos": [232, 236]}], "task": "NER"}
{"text": "Since nearly all transformants involving homeologous DNAs carried a single recombinant plasmid in both Pms + and Pms - strains , stable heteroduplex DNA appears less likely than for homologous DNAs .", "entity": [{"entity": "Pms +", "entity_type": "GENE", "pos": [103, 108]}, {"entity": "Pms -", "entity_type": "GENE", "pos": [113, 118]}], "task": "NER"}
{"text": "Western and immunocytochemical analysis implied that PREB accumulates specifically in GH3 cell nuclei .", "entity": [{"entity": "PREB", "entity_type": "GENE", "pos": [53, 57]}], "task": "NER"}
{"text": "Coronary arteries were found in the biopsy tissue of 30 ( 76 % ) of the 39 patients who formed the study group .", "entity": [], "task": "NER"}
{"text": "Cotransfection of a junB stimulated the basal activity of the alpha 2 ( I ) collagen promoter 93 - fold , respectively .", "entity": [{"entity": "junB", "entity_type": "GENE", "pos": [20, 24]}, {"entity": "alpha 2 ( I ) collagen promoter", "entity_type": "GENE", "pos": [62, 93]}], "task": "NER"}
{"text": "The extraordinary high substrate specificity of rPulA together with its thermal stability makes this enzyme a good candidate for biotechnological applications in the starch - processing industry .", "entity": [{"entity": "rPulA", "entity_type": "GENE", "pos": [48, 53]}], "task": "NER"}
{"text": "An atypical form of juvenile myasthenia gravis associated with severe emaciation , muscle atrophy , ophthalmoplegia , bulbar signs and joint contracture", "entity": [], "task": "NER"}
{"text": "Anesthesia was induced by droperidol 0 . 2 mg . kg - 1 , fentanyl 50 micrograms , thiamylal 150 - 250 mg , and succinylcholine 1 mg . kg - 1 , and maintained with nitrous oxide and O2 ( 67 : 33 ) supplemented with repeated i . v . doses of fentanyl ( within 15 micrograms . kg - 1 ) .", "entity": [], "task": "NER"}
{"text": "In this system , enhancers act primarily to increase the probability of rapid and efficient transcription complex formation and initiation .", "entity": [], "task": "NER"}
{"text": "( i ) p60 bound fast - migrating , underprocessed wild - type ICP22 and ICP22 lacking the carboxyl - terminal 24 amino acids but not ICP22 lacking the carboxyl - terminal 40 amino acids , whereas the previously identified cellular protein p78 ( R .", "entity": [{"entity": "p60", "entity_type": "GENE", "pos": [6, 9]}, {"entity": "wild - type ICP22", "entity_type": "GENE", "pos": [50, 67]}, {"entity": "ICP22", "entity_type": "GENE", "pos": [72, 77]}, {"entity": "ICP22", "entity_type": "GENE", "pos": [133, 138]}, {"entity": "cellular protein p78", "entity_type": "GENE", "pos": [222, 242]}], "task": "NER"}
{"text": "Hetero - oligomerization of Smad4 with the pathway - restricted SMAD proteins is essential for Smad4 - mediated transcription .", "entity": [{"entity": "Smad4", "entity_type": "GENE", "pos": [28, 33]}, {"entity": "SMAD proteins", "entity_type": "GENE", "pos": [64, 77]}, {"entity": "Smad4", "entity_type": "GENE", "pos": [95, 100]}], "task": "NER"}
{"text": "This group showed the presence of bacteria infiltrated at the dentinal tubules coronally and into the root canals .", "entity": [], "task": "NER"}
{"text": "Hydroxyl radical footprinting of DNA complexes of the ets domain of PU . 1 and its comparison to the crystal structure .", "entity": [{"entity": "ets domain", "entity_type": "GENE", "pos": [54, 64]}, {"entity": "PU . 1", "entity_type": "GENE", "pos": [68, 74]}], "task": "NER"}
{"text": "Autophosphorylation on the major phosphorylation site Y1235 upregulates the kinase activity of the receptor , increasing the Vmax of the phosphotransfer reaction .", "entity": [], "task": "NER"}
{"text": "The generation of dorso - ventral polarity during Drosophila embryogenesis is regulated by the action of 12 maternally expressed gene products , the dorsal group .", "entity": [{"entity": "dorsal group", "entity_type": "GENE", "pos": [149, 161]}], "task": "NER"}
{"text": "Immunoblot analysis of purified and protease - digested intracellular mature virus ( IMV ) and extracellular enveloped virus ( EEV ) showed that the A36R proteins were present on the surface of EEV with type II membrane topology , but were absent from IMV .", "entity": [{"entity": "A36R proteins", "entity_type": "GENE", "pos": [149, 162]}], "task": "NER"}
{"text": "To prevent section wrinkles usually encountered with the use of coated single - hole grids , a simple method was developed .", "entity": [], "task": "NER"}
{"text": "An alternative approach to random integration of large DNA fragments into plants is to utilize one of several site - specific recombination ( SSR ) systems , such as Cre / lox .", "entity": [{"entity": "Cre", "entity_type": "GENE", "pos": [166, 169]}, {"entity": "lox", "entity_type": "GENE", "pos": [172, 175]}], "task": "NER"}
{"text": "Both v - Myb and c - Myb bind specifically to delta E3 .", "entity": [{"entity": "v - Myb", "entity_type": "GENE", "pos": [5, 12]}, {"entity": "c - Myb", "entity_type": "GENE", "pos": [17, 24]}, {"entity": "delta E3", "entity_type": "GENE", "pos": [46, 54]}], "task": "NER"}
{"text": "After at least one year follow - up , argon laser showed a statistically significant effect ( p less of 0 , 01 ; Kolmogorow - Smirnov test ) on the stabilization or the amelioration of visual acuity compared with the non treated group .", "entity": [], "task": "NER"}
{"text": "As part of a large Dutch prospective multicenter study ( Netherlands Cooperative Study on the Adequacy of Dialysis - 2 ) , we consecutively included all new patients with end - stage renal disease for whom residual renal function could be obtained 0 to 4 weeks before the start of dialysis therapy .", "entity": [], "task": "NER"}
{"text": "Relationship between age - associated endocrine deficiencies and muscle function in elderly women : a cross - sectional study .", "entity": [], "task": "NER"}
{"text": "Intensity variations from the variable TR were removed , and the data were evaluated for correlation with the lateralized stimulus .", "entity": [], "task": "NER"}
{"text": "Improvement of some pharmaceutical properties of clofibrate by cyclodextrin complexation .", "entity": [], "task": "NER"}
{"text": "We assessed cardiovascular variables and blood O2 contents in order to characterize O2 transport in ponies during treadmill exercise .", "entity": [], "task": "NER"}
{"text": "Somatic and visceral inputs to the thoracic spinal cord of the cat : effects of noxious stimulation of the biliary system .", "entity": [], "task": "NER"}
{"text": "Some of these DNA : protein complexes were also present , but at lower levels , in nuclear extracts from untransformed rat cells suggesting the possible involvement of cellular factors in the mechanism of down - regulation mediated by Ad12 E1A .", "entity": [{"entity": "Ad12 E1A", "entity_type": "GENE", "pos": [235, 243]}], "task": "NER"}
{"text": "We suggest that the induction of IFNA promoter region requires cooperation between alpha F1 binding proteins and IRF - 1 .", "entity": [{"entity": "IFNA promoter region", "entity_type": "GENE", "pos": [33, 53]}, {"entity": "alpha F1 binding proteins", "entity_type": "GENE", "pos": [83, 108]}, {"entity": "IRF - 1", "entity_type": "GENE", "pos": [113, 120]}], "task": "NER"}
{"text": "Two pharmacokinetic models were compared .", "entity": [], "task": "NER"}
{"text": "Morphine administration acutely reduced plasma clearance of sulfobromophthalein ( BSP ) in mice and increased hepatic retention of this dye .", "entity": [], "task": "NER"}
{"text": "A Buddhist view of abortion .", "entity": [], "task": "NER"}
{"text": "Cryoglobulinaemia among maintenance haemodialysis patients and its relation to hepatitis C infection .", "entity": [], "task": "NER"}
{"text": "In HepG2 cells , SREBP - 1c mRNA and precursor protein levels were induced by treatment with 22 ( R ) - hydroxycholesterol and 9 - cis - retinoic acid , confirming that endogenous LXR - RXR activation can induce endogenous SREBP - 1c expression .", "entity": [{"entity": "SREBP - 1c mRNA", "entity_type": "GENE", "pos": [17, 32]}, {"entity": "LXR", "entity_type": "GENE", "pos": [180, 183]}, {"entity": "RXR", "entity_type": "GENE", "pos": [186, 189]}, {"entity": "endogenous SREBP - 1c", "entity_type": "GENE", "pos": [212, 233]}], "task": "NER"}
{"text": "The T ( CCO2 ) was related to the PCO2 by a Pearson product coefficient of 0 . 79 ( p < . 0005 ) , with a mean difference of 1 . 94 ( T ( CCO2 ) > P ( CO2 ) and 95 % confidence interval of - 0 . 12 to 4 . 07 .", "entity": [], "task": "NER"}
{"text": "Comparison of the footprint patterns of the mouse and human HPRT genes demonstrated that the in vivo binding of regulatory proteins between these species is generally conserved but not identical .", "entity": [{"entity": "mouse and human HPRT genes", "entity_type": "GENE", "pos": [44, 70]}], "task": "NER"}
{"text": "In this study , we sought to determine the specific effect of HIV protease inhibitors on patient weight .", "entity": [{"entity": "HIV protease", "entity_type": "GENE", "pos": [62, 74]}], "task": "NER"}
{"text": "The cats with stage - 2 lymphomas that were FeLV - test negative had the best response to treatment .", "entity": [], "task": "NER"}
{"text": "E1 recognition sequences in the bovine papillomavirus type 1 origin of DNA replication : interaction between half sites of the inverted repeats .", "entity": [{"entity": "E1", "entity_type": "GENE", "pos": [0, 2]}], "task": "NER"}
{"text": "Phase I study of 5 - fluorouracil and leucovorin by a 14 - day circadian infusion in metastatic adenocarcinoma patients .", "entity": [], "task": "NER"}
{"text": "Although polyubiquitin chains linked through Lys ( 29 ) of ubiquitin have been implicated in the targeting of certain substrates to proteasomes , the signaling properties of these chains are poorly understood .", "entity": [{"entity": "polyubiquitin chains", "entity_type": "GENE", "pos": [9, 29]}, {"entity": "ubiquitin", "entity_type": "GENE", "pos": [59, 68]}], "task": "NER"}
{"text": "B and C1 fusions with yeast GAL4 DNA - binding and transcriptional activation domains were also found to interact when synthesized and assayed in yeast .", "entity": [{"entity": "B", "entity_type": "GENE", "pos": [0, 1]}, {"entity": "C1 fusions", "entity_type": "GENE", "pos": [6, 16]}, {"entity": "yeast GAL4 DNA - binding and transcriptional activation domains", "entity_type": "GENE", "pos": [22, 85]}], "task": "NER"}
{"text": "Deletion analysis of the 7 . 3 - kb GATA - 2 promoter region revealed that a 1 . 1 - kb DNA sequence is critical for expression of GATA - 2 in neurons .", "entity": [{"entity": "7 . 3 - kb GATA - 2 promoter region", "entity_type": "GENE", "pos": [25, 60]}, {"entity": "GATA - 2", "entity_type": "GENE", "pos": [131, 139]}], "task": "NER"}
{"text": "In this study , we verified that PI 3 - kinase associates with the CD4 : p56lck complex as judged by the presence of PI 3 - phosphate generated from anti - CD4 immunoprecipitates and detected by high - pressure liquid chromatographic analysis .", "entity": [{"entity": "PI 3 - kinase", "entity_type": "GENE", "pos": [33, 46]}, {"entity": "CD4", "entity_type": "GENE", "pos": [67, 70]}, {"entity": "p56lck complex", "entity_type": "GENE", "pos": [73, 87]}, {"entity": "anti - CD4", "entity_type": "GENE", "pos": [149, 159]}], "task": "NER"}
{"text": "Reality and clinical application of immunoglobulin preparations", "entity": [{"entity": "immunoglobulin", "entity_type": "GENE", "pos": [36, 50]}], "task": "NER"}
{"text": "This evidence , together with the ability of a carboxyl - terminal coding sequence starting from the BamHI site to complement a shy1 mutant , suggests that the Shy1p contains two domains that can be separately expressed to form a functional protein .", "entity": [{"entity": "BamHI site", "entity_type": "GENE", "pos": [101, 111]}, {"entity": "shy1 mutant", "entity_type": "GENE", "pos": [128, 139]}, {"entity": "Shy1p", "entity_type": "GENE", "pos": [160, 165]}], "task": "NER"}
{"text": "We have previously shown that UNC - 4 expression in the VA motor neurons specifies the wild - type pattern of presynaptic input .", "entity": [{"entity": "UNC - 4", "entity_type": "GENE", "pos": [30, 37]}], "task": "NER"}
{"text": "However , technical advances have shown the limitations of these tests as tests for IgM can be positive because of residual specific IgM or even in subjects free of acute infection due to the existence of natural interfering IgM .", "entity": [{"entity": "IgM", "entity_type": "GENE", "pos": [84, 87]}, {"entity": "IgM", "entity_type": "GENE", "pos": [133, 136]}, {"entity": "IgM", "entity_type": "GENE", "pos": [225, 228]}], "task": "NER"}
{"text": "Transesophageal echocardiography risk factors for stroke in nonvalvular atrial fibrillation .", "entity": [], "task": "NER"}
{"text": "Therefore , in VDR - mediated transcriptional activation , 1 , 25 ( OH ) 2D3 binding to VDR alters the conformation of the ligand binding domain such that it : ( i ) engages in strong heterodimerization with RXR to facilitate VDRE binding , ( ii ) influences the RXR ligand binding domain such that it is resistant to the binding of 9 - cis RA but active in recruiting coactivator to its AF - 2 and ( iii ) presents the AF - 2 region in VDR for coactivator association .", "entity": [{"entity": "VDR", "entity_type": "GENE", "pos": [15, 18]}, {"entity": "VDR", "entity_type": "GENE", "pos": [88, 91]}, {"entity": "RXR", "entity_type": "GENE", "pos": [208, 211]}, {"entity": "RXR ligand binding domain", "entity_type": "GENE", "pos": [263, 288]}, {"entity": "VDR", "entity_type": "GENE", "pos": [437, 440]}], "task": "NER"}
{"text": "Our case , however , had no histologic evidence of malignancy , no serum alpha fetoprotein at 7 months of age , and no recurrence at 1 years .", "entity": [{"entity": "serum alpha fetoprotein", "entity_type": "GENE", "pos": [67, 90]}], "task": "NER"}
{"text": "Second , overexpression of RIM11 can suppress an ime1 missense mutation ( ime1 - L321F ) but not an ime1 deletion .", "entity": [{"entity": "RIM11", "entity_type": "GENE", "pos": [27, 32]}, {"entity": "ime1", "entity_type": "GENE", "pos": [49, 53]}, {"entity": "ime1 - L321F", "entity_type": "GENE", "pos": [74, 86]}, {"entity": "ime1", "entity_type": "GENE", "pos": [100, 104]}], "task": "NER"}
{"text": "It is always present and has a discrete origin and insertion .", "entity": [], "task": "NER"}
{"text": "We evaluated 99mTc - ECD SPECT comparing with rCBF images obtained by PET in 12 patients with spinocerebellar degeneration ( SCD ) .", "entity": [], "task": "NER"}
{"text": "Nimodipine ( 5 micrograms / kg ) followed by infusion of 0 . 75 microgram / kg / min lowered the blood pressure by 10 % in both normotensive and hypertensive rats ; the same dose schedule of nifedipine did not lower MAP .", "entity": [], "task": "NER"}
{"text": "When severe hypoxia was acutely produced by ventilation with low - oxygen mixtures in experimental ( PaO2 , 23 . 7 + / - 1 . 7 torr ) and control animals ( PaO2 , 26 . 3 + / - 1 . 0 torr ) , plasma insulin responses were markedly inhibited in both .", "entity": [{"entity": "plasma insulin", "entity_type": "GENE", "pos": [191, 205]}], "task": "NER"}
{"text": "We have raised antibodies against a peptide specific to the predicted protein product of this second mRNA .", "entity": [], "task": "NER"}
{"text": "Using unidirectional PCR we isolated a 361 - bp 5 ' promoter region and delineated the intronic / exonic boundaries which include a non - coding exon 1 , a single intron , and a coding exon 2 , a structure that is typical of genes of the RNase A superfamily .", "entity": [{"entity": "RNase A superfamily", "entity_type": "GENE", "pos": [238, 257]}], "task": "NER"}
{"text": "Results of these studies indicate that binding of biotin to the protein results in protection of regions of the central domain in the vicinity of the active site and the C - terminal domain from chemical cleavage .", "entity": [], "task": "NER"}
{"text": "The family histories were obtained from the parents .", "entity": [], "task": "NER"}
{"text": "Absence of nitroso formation from ( 14C ) methomyl and sodium nitrite under simulated stomach conditions .", "entity": [], "task": "NER"}
{"text": "The structure of the murine Dtk gene has been determined .", "entity": [{"entity": "murine Dtk gene", "entity_type": "GENE", "pos": [21, 36]}], "task": "NER"}
{"text": "Outlook in oral and cutaneous Kaposi ' s sarcoma .", "entity": [], "task": "NER"}
{"text": "These data demonstrate that oleosin gene transcription is regulated in a tissue - specific and temporally regulated manner and clearly indicate that oleosin protein expression is co - ordinated primarily at the transcriptional level .", "entity": [{"entity": "oleosin gene", "entity_type": "GENE", "pos": [28, 40]}, {"entity": "oleosin protein", "entity_type": "GENE", "pos": [149, 164]}], "task": "NER"}
{"text": "Allergic field : how to detect it ?", "entity": [], "task": "NER"}
{"text": "The actual placement of the lesions was determined after mapping of the GPi by microrecording , using stimulation to identify the sensorimotor region and its somatotopic organization .", "entity": [], "task": "NER"}
{"text": "The 0 . 018 - inch FloWire provides a high - fidelity continuous Doppler signal .", "entity": [], "task": "NER"}
{"text": "Other recommendations for enhancing the safety of potent antiplatelet agents in a variety of clinical situations are provided .", "entity": [], "task": "NER"}
{"text": "The concepts were developed by Mines and Garrey during the next 10 years .", "entity": [], "task": "NER"}
{"text": "A new simple identification of rheumatoid factor on nitrocellulose was developed that allows quantitative detection .", "entity": [{"entity": "rheumatoid factor", "entity_type": "GENE", "pos": [31, 48]}], "task": "NER"}
{"text": "Maximum overexpression of holoenzyme activity was achieved by the inclusion in such plasmids of Salmonella typhimurium cysG , which encodes a uroporphyrinogen III methyltransferase required for the synthesis of siroheme , a cofactor for the hemoprotein .", "entity": [{"entity": "uroporphyrinogen III methyltransferase", "entity_type": "GENE", "pos": [142, 180]}], "task": "NER"}
{"text": "Determination of the LD 50 ( 30 ) during infant period and growth period", "entity": [], "task": "NER"}
{"text": "Mutational analysis of yeast CEG1 demonstrated that four of the five conserved motifs are essential for capping enzyme function in vivo .", "entity": [{"entity": "yeast CEG1", "entity_type": "GENE", "pos": [23, 33]}, {"entity": "capping enzyme", "entity_type": "GENE", "pos": [104, 118]}], "task": "NER"}
{"text": "Purified phosphorylated PhoP ( PhoPP ) had a half - life of approximately 2 . 5 h , which was reduced to about 15 min by addition of the same molar amount of * PhoR ( the cytoplasmic region of PhoR ) .", "entity": [{"entity": "PhoP", "entity_type": "GENE", "pos": [24, 28]}, {"entity": "PhoPP", "entity_type": "GENE", "pos": [31, 36]}, {"entity": "* PhoR", "entity_type": "GENE", "pos": [158, 164]}, {"entity": "PhoR", "entity_type": "GENE", "pos": [193, 197]}], "task": "NER"}
{"text": "We conclude that exercise - induced ST - segment elevation in patients without a history of myocardial infarction or left ventricular aneurysm is caused by coronary spasm of a major coronary vessel .", "entity": [], "task": "NER"}
{"text": "It spans 20 kilobases , consists of 7 exons and 6 introns , and contains a TATA motif 24 nucleotides upstream of the transcriptional start site .", "entity": [], "task": "NER"}
{"text": "Metastatic tumours of bone in Nigerians .", "entity": [], "task": "NER"}
{"text": "A survey of 274 late detected cases of CDH born in the years 1970 - - 74 is presented .", "entity": [], "task": "NER"}
{"text": "This distinct biochemical difference between STAT5A and STAT5B was confirmed with purified activated STAT5 recombinant proteins .", "entity": [{"entity": "STAT5A", "entity_type": "GENE", "pos": [45, 51]}, {"entity": "STAT5B", "entity_type": "GENE", "pos": [56, 62]}, {"entity": "STAT5 recombinant proteins", "entity_type": "GENE", "pos": [101, 127]}], "task": "NER"}
{"text": "Enoxacin has been shown to be an effective well tolerated and convenient treatment for gonorrhoea .", "entity": [], "task": "NER"}
{"text": "METHODS : Precision and accuracy were measured using controls and method comparison studies .", "entity": [], "task": "NER"}
{"text": "Important prognostic factors for the results of physiotherapeutic exercises in intermittent claudication", "entity": [], "task": "NER"}
{"text": "Thus , Tax1 activates CArG - mediated transcription without mitogenic signals through interaction with a CArG - binding factor , p67SRF .", "entity": [{"entity": "Tax1", "entity_type": "GENE", "pos": [7, 11]}, {"entity": "CArG - binding factor", "entity_type": "GENE", "pos": [105, 126]}, {"entity": "p67SRF", "entity_type": "GENE", "pos": [129, 135]}], "task": "NER"}
{"text": "In 5 cases , combined sensitization to mercury and other metal salts , particularly gold sodium thiosulfate ( GST ) and palladium chloride ( PDC ) , was observed .", "entity": [], "task": "NER"}
{"text": "Amongst 53 \" inoperable \" ( T4 , N0 , N1 , T . , N2 , N3 ) cases , 5 ( 10 % ) had a positive scan and 5 a doubtful scan .", "entity": [], "task": "NER"}
{"text": "Acyclovir ( 3 % ointment ) used topically one to five times a day on acute ocular HSV infection gave beneficial results as measured by a reduction in corneal involvement , conjunctivitis , iritis , and corneal clouding .", "entity": [], "task": "NER"}
{"text": "The efficiency of transfections was normalized relative to the net amount of CAT plasmid actually transfected into recipient cells , determined by a modified Southern hybridization procedure .", "entity": [{"entity": "CAT", "entity_type": "GENE", "pos": [77, 80]}], "task": "NER"}
{"text": "Initial computer based similarity searches identified human retinoblastoma binding protein 1 ( RBP - 1 ) , Drosophila melanogaster male specific lethal - 3 ( Msl - 3 ) , S . pombe altered polarity - 13 ( Alp13 ) and S . cerevisiae Eaf3p , a component of the yeast NuA4 HAT complex ( Galarneau et al . , 2000 .", "entity": [{"entity": "human retinoblastoma binding protein 1", "entity_type": "GENE", "pos": [54, 92]}, {"entity": "RBP - 1", "entity_type": "GENE", "pos": [95, 102]}, {"entity": "Drosophila melanogaster male specific lethal - 3", "entity_type": "GENE", "pos": [107, 155]}, {"entity": "Msl - 3", "entity_type": "GENE", "pos": [158, 165]}, {"entity": "S . pombe altered polarity - 13", "entity_type": "GENE", "pos": [170, 201]}, {"entity": "Alp13", "entity_type": "GENE", "pos": [204, 209]}, {"entity": "S . cerevisiae Eaf3p", "entity_type": "GENE", "pos": [216, 236]}, {"entity": "yeast NuA4", "entity_type": "GENE", "pos": [258, 268]}, {"entity": "HAT", "entity_type": "GENE", "pos": [269, 272]}], "task": "NER"}
{"text": "These aa residues correspond to codons 59 and 108 in the P . falciparum DHFR active site in which similar aa substitutions ( Cys Arg - 59 and Ser Asn - 108 ) are associated with pyrimethamine resistance .", "entity": [{"entity": "P . falciparum DHFR active site", "entity_type": "GENE", "pos": [57, 88]}], "task": "NER"}
{"text": "Efficacy was evaluated in 24 patients , of whom eight received RD and 16 SD .", "entity": [], "task": "NER"}
{"text": "Short - term growth : rhythms , chaos , or noise ?", "entity": [], "task": "NER"}
{"text": "Sequences homologous to the consensus TUF - binding UAS boxes are present in the 5 ' flanking regions of both genes .", "entity": [{"entity": "TUF - binding UAS boxes", "entity_type": "GENE", "pos": [38, 61]}], "task": "NER"}
{"text": "Residues crucial for Ras interaction with GDP - GTP exchangers .", "entity": [{"entity": "Ras", "entity_type": "GENE", "pos": [21, 24]}, {"entity": "GDP - GTP exchangers", "entity_type": "GENE", "pos": [42, 62]}], "task": "NER"}
{"text": "The gene atp6 , encoding subunit 6 of the mitochondrial F0 - ATPase complex , has been characterized from both the normal ( fertile ) and Ogura ( male - sterile ) radish cytoplasms in order to determine if previously identified atp6 transcriptional differences could play a role in cytoplasmic male sterility .", "entity": [{"entity": "gene atp6", "entity_type": "GENE", "pos": [4, 13]}, {"entity": "F0", "entity_type": "GENE", "pos": [56, 58]}, {"entity": "ATPase", "entity_type": "GENE", "pos": [61, 67]}, {"entity": "atp6", "entity_type": "GENE", "pos": [228, 232]}], "task": "NER"}
{"text": "To determine whether the transcript encodes an active enzyme , we developed a novel transient embryonic excision assay in which zebrafish fertilized eggs were co - injected with RNA transcribed in vitro using the Tol2 cDNA as a template and a plasmid DNA harboring a nonautonomous Tol2 element , which has a deletion in the transposase coding region .", "entity": [{"entity": "Tol2 cDNA", "entity_type": "GENE", "pos": [213, 222]}, {"entity": "Tol2 element", "entity_type": "GENE", "pos": [281, 293]}, {"entity": "transposase coding region", "entity_type": "GENE", "pos": [324, 349]}], "task": "NER"}
{"text": "The expression of CAPL , a second protein involved in calcium metabolism , was only moderately elevated in the doxorubicin - resistant cells .", "entity": [{"entity": "CAPL", "entity_type": "GENE", "pos": [18, 22]}], "task": "NER"}
{"text": "The reconstituted enzyme binds DNA with an affinity that is approximately 20 - fold lower than that of the intact topo70 .", "entity": [{"entity": "topo70", "entity_type": "GENE", "pos": [114, 120]}], "task": "NER"}
{"text": "In late October , 1974 , Staphylococcus aureus postoperative wound infection was recorded in a nonhuman primate ( Macaca mulatta ) which had recently undergone surgical operation .", "entity": [], "task": "NER"}
{"text": "Thus , the in vivo function of Gle2p is strictly coupled to the short GLEBS within Nup116p which links this putative mRNA transport factor to the nuclear pores .", "entity": [{"entity": "Gle2p", "entity_type": "GENE", "pos": [31, 36]}, {"entity": "GLEBS", "entity_type": "GENE", "pos": [70, 75]}, {"entity": "Nup116p", "entity_type": "GENE", "pos": [83, 90]}], "task": "NER"}
{"text": "Seminal prolactin levels were significantly elevated in all infertile males .", "entity": [{"entity": "prolactin", "entity_type": "GENE", "pos": [8, 17]}], "task": "NER"}
{"text": "The recruitment of constitutively phosphorylated p185 ( neu ) and the activated mitogenic pathway proteins to this membrane - microfilament interaction site provides a physical model for integrating the assembly of the mitogenic pathway with the transmission of growth factor signal to the cytoskeleton .", "entity": [{"entity": "p185", "entity_type": "GENE", "pos": [49, 53]}, {"entity": "neu", "entity_type": "GENE", "pos": [56, 59]}], "task": "NER"}
{"text": "The pattern of net RNA expression in adult mouse tissues is different .", "entity": [{"entity": "net RNA", "entity_type": "GENE", "pos": [15, 22]}], "task": "NER"}
{"text": "Effect of capsaicin on hexobarbital - anesthetized rats", "entity": [], "task": "NER"}
{"text": "Expression of human complement receptor type 2 ( CR2 / CD21 ) is primarily restricted to mature B cells and follicular dendritic cells .", "entity": [{"entity": "human complement receptor type 2", "entity_type": "GENE", "pos": [14, 46]}, {"entity": "CR2", "entity_type": "GENE", "pos": [49, 52]}, {"entity": "CD21", "entity_type": "GENE", "pos": [55, 59]}], "task": "NER"}
{"text": "A physical and genetic map covering the entire RP12 candidate gene region was constructed .", "entity": [{"entity": "RP12 candidate gene region", "entity_type": "GENE", "pos": [47, 73]}], "task": "NER"}
{"text": "We found that in premature infants plasminogen levels are low ; thus , defense against intra - alveolar fibrin deposition during birth trauma is reduced .", "entity": [{"entity": "plasminogen", "entity_type": "GENE", "pos": [35, 46]}, {"entity": "fibrin", "entity_type": "GENE", "pos": [104, 110]}], "task": "NER"}
{"text": "Progestins : present and future .", "entity": [], "task": "NER"}
{"text": "Indeed , DEX also enhanced the RA - dependent increase in RARbeta mRNA in a cycloheximide - sensitive manner .", "entity": [{"entity": "RARbeta mRNA", "entity_type": "GENE", "pos": [58, 70]}], "task": "NER"}
{"text": "In both immortalized and normal diploid human cells , wt AAV targeted integration to ch - 19 .", "entity": [], "task": "NER"}
{"text": "It was found that both versions of the brief SL & amp ; shy ; ASIA had similar correlations to the target variables as the full scale SL & amp ; shy ; ASIA .", "entity": [], "task": "NER"}
{"text": "These operons encode subunits of photosystems I ( psa ) and II ( psb ) , the cytochrome bGf complex ( pet ) , the plastid NAD ( P ) H dehydrogenase ( ndh ) , and the unidentified open reading frame ycf9 .", "entity": [{"entity": "photosystems I", "entity_type": "GENE", "pos": [33, 47]}, {"entity": "psa", "entity_type": "GENE", "pos": [50, 53]}, {"entity": "psb", "entity_type": "GENE", "pos": [65, 68]}, {"entity": "cytochrome bGf complex", "entity_type": "GENE", "pos": [77, 99]}, {"entity": "pet", "entity_type": "GENE", "pos": [102, 105]}, {"entity": "NAD ( P ) H dehydrogenase", "entity_type": "GENE", "pos": [122, 147]}, {"entity": "ndh", "entity_type": "GENE", "pos": [150, 153]}, {"entity": "ycf9", "entity_type": "GENE", "pos": [198, 202]}], "task": "NER"}
{"text": "In contrast , dominant negative Rac ( N17Rac1 ) inhibited JNK activation by Galpha12 in HEK293 cells as well as three other cell lines .", "entity": [{"entity": "dominant negative Rac", "entity_type": "GENE", "pos": [14, 35]}, {"entity": "N17Rac1", "entity_type": "GENE", "pos": [38, 45]}, {"entity": "JNK", "entity_type": "GENE", "pos": [58, 61]}, {"entity": "Galpha12", "entity_type": "GENE", "pos": [76, 84]}], "task": "NER"}
{"text": "A major feature of this genomic sequence is the presence of a first intron ( Il ) , 215 bp long , located 48 bp downstream of the translation start ATG codon .", "entity": [], "task": "NER"}
{"text": "We reviewed the different published cases of acute high dose methotrexate neurotoxicity and the different underlying mechanisms .", "entity": [], "task": "NER"}
{"text": "The expected products of the cloned bph genes , except bphA3 , were observed in E . coli in an in vitro transcription - translation system .", "entity": [{"entity": "bph genes", "entity_type": "GENE", "pos": [36, 45]}, {"entity": "bphA3", "entity_type": "GENE", "pos": [55, 60]}], "task": "NER"}
{"text": "The immunoreactive antithrombin III increased significantly while the increase in antithrombin III activity was insignificant in 20 male Caucasian Danes upon 3 weeks supplementation of the diet with 10 ml daily of a cod liver oil concentrate .", "entity": [{"entity": "antithrombin III", "entity_type": "GENE", "pos": [19, 35]}, {"entity": "antithrombin III", "entity_type": "GENE", "pos": [82, 98]}], "task": "NER"}
{"text": "Only the 27 - kDa protein was detected after N - glycosidase treatment , indicating that PLP - H is a glycoprotein .", "entity": [{"entity": "N - glycosidase", "entity_type": "GENE", "pos": [45, 60]}, {"entity": "PLP - H", "entity_type": "GENE", "pos": [89, 96]}], "task": "NER"}
{"text": "These observed changes were not found when assessing NPY level in plasma fluid .", "entity": [{"entity": "NPY", "entity_type": "GENE", "pos": [53, 56]}], "task": "NER"}
{"text": "In three other patients the electrophysiologic characteristics of atrioventricular conduction prevented a demonstration of these differences .", "entity": [], "task": "NER"}
{"text": "These sequence differences are reflected in differences in gene expression in three cell lines .", "entity": [], "task": "NER"}
{"text": "The 10 eyes injected with human RPE cells showed STAGE 2 or less in 4 weeks .", "entity": [], "task": "NER"}
{"text": "The cumulative dose to nursing staff for the week after treatment was dependent on patient mobility and was estimated at 0 . 08 mSv for a self - caring patient to 6 . 3 mSv for a totally helpless patient ( 1840 MBq / group A ) .", "entity": [], "task": "NER"}
{"text": "The analysis consisted of 1 ) fitting first - and second - order autoregressive models ( AR1 and AR2 ) and 2 ) obtaining the power spectra of the data by fast - Fourier transform .", "entity": [], "task": "NER"}
{"text": "Of 921 specimens , 95 yielded non - albicans species , mainly from patients with low CD4 lymphocyte counts and extensive previous azole exposure .", "entity": [{"entity": "CD4", "entity_type": "GENE", "pos": [85, 88]}], "task": "NER"}
{"text": "Sequence analysis and electrophoretic mobility shift experiments suggest that GnSE response elements interact , in these two regions , with GATA - and LIM - related factors , respectively .", "entity": [{"entity": "GnSE response elements", "entity_type": "GENE", "pos": [78, 100]}, {"entity": "GATA - and LIM - related factors", "entity_type": "GENE", "pos": [140, 172]}], "task": "NER"}
{"text": "The NrfC polypeptide , M ( r ) 24 , 567 , contains 16 cysteine residues arranged in four clusters typical of the CooF super - family of non - haem iron - sulphur proteins .", "entity": [{"entity": "NrfC polypeptide", "entity_type": "GENE", "pos": [4, 20]}, {"entity": "M ( r ) 24 , 567", "entity_type": "GENE", "pos": [23, 39]}, {"entity": "CooF super - family", "entity_type": "GENE", "pos": [113, 132]}], "task": "NER"}
{"text": "Hamdija Karamehmedovic ; Ibn al - Nefis , \" Mudzez al - Kanum \" , Republicki zavod za zdravstvenu zastitu Sarajevo , 1961 , 1 - 219 ; Mr ph Samuel Elazar , Ajnija Omanic : \" Bibliografija medicinskih djela u SR BiH do 1895 . \" Medicinska knjiga Beograd - Zagreb 1984 ; Besides , the great contribution in bibliography was given by dr Lujo Taler , prof . dr .", "entity": [], "task": "NER"}
{"text": "Patients randomized into the active treatment groups A30 ( n = 49 ) and A60 ( n = 48 ) received topical treatment with 3 . 0 % diclofenac in 2 . 5 % hyaluronan gel 0 . 5 g twice daily for 30 or 60 days , respectively .", "entity": [], "task": "NER"}
{"text": "Southern blot analysis performed on genomic DNA demonstrated altered CpG methylation within intron 1 in DNA from all BCC compared to normal , mortal human mammary epithelial cells ( HMEC ) .", "entity": [], "task": "NER"}
{"text": "In addition , both inhibitors blocked phosphatidylcholine hydrolysis and protein kinase C translocation .", "entity": [{"entity": "protein kinase C", "entity_type": "GENE", "pos": [73, 89]}], "task": "NER"}
{"text": "Human PDNP3 is expressed in glioma cells , prostate , and uterus , but not in the alimentary tract .", "entity": [{"entity": "Human PDNP3", "entity_type": "GENE", "pos": [0, 11]}], "task": "NER"}
{"text": "13 : 961 - 969 , 1993 ) suggested that T antigen could mediate transcriptional activation through interaction with the TATA - binding protein , as well as upstream bound transcription factors .", "entity": [{"entity": "T antigen", "entity_type": "GENE", "pos": [39, 48]}, {"entity": "TATA - binding protein", "entity_type": "GENE", "pos": [119, 141]}], "task": "NER"}
{"text": "Identification of a putative infC - rpmI - rplT operon flanked by long inverted repeats in Mycoplasma fermentans ( incognitus strain ) .", "entity": [{"entity": "infC", "entity_type": "GENE", "pos": [29, 33]}, {"entity": "rpmI", "entity_type": "GENE", "pos": [36, 40]}, {"entity": "rplT", "entity_type": "GENE", "pos": [43, 47]}], "task": "NER"}
{"text": "IgE antibody to twelve common food and inhalant allergens was measured by enzyme - linked immunosorbent assay ( ELISA ) in the sera of thirteen atopic patients with one or more allergic disorders ( asthma occurring in eleven ; rhinitis in ten ; eczema in six ; urticaria in four ; mouth and gastro - intestinal symptoms in six ) , of twelve non - atopic patients with various clinical symptoms ( asthma in four ; rhinitis in four ; eczema in one ; urticaria in two ; mouth and gastro - intestinal symptoms in four ) and sixteen cord blood sera .", "entity": [{"entity": "IgE antibody", "entity_type": "GENE", "pos": [0, 12]}], "task": "NER"}
{"text": "Analysis of 1 Mb of published sequence from the region of conserved synteny on human chromosome 5q31 - q33 identified 45 gene candidates , including 35 expressed genes in the human IL - 4 cytokine gene cluster .", "entity": [{"entity": "human IL - 4 cytokine gene", "entity_type": "GENE", "pos": [175, 201]}], "task": "NER"}
{"text": "These p21 - E2F complexes , while present in young G1 cells at very low levels , were elevated in senescent cells .", "entity": [{"entity": "p21", "entity_type": "GENE", "pos": [6, 9]}, {"entity": "E2F", "entity_type": "GENE", "pos": [12, 15]}], "task": "NER"}
{"text": "The delta Mo + SV tumor DNAs from B - lineage tumors were typically rearranged at the immunoglobulin gene loci and contained germ line configurations of the T - cell receptor beta gene .", "entity": [{"entity": "immunoglobulin gene loci", "entity_type": "GENE", "pos": [86, 110]}, {"entity": "T - cell receptor beta gene", "entity_type": "GENE", "pos": [157, 184]}], "task": "NER"}
{"text": "An increased incidence of ATN has been reported since the introduction of cyclosporin A .", "entity": [], "task": "NER"}
{"text": "Earlier reports have localized mutations which affect the processing and transport of herpes simplex virus 1 glycoproteins to a region located between the genes specifying glycoprotein B and the major viral DNA - binding protein ( beta 8 ) .", "entity": [{"entity": "glycoprotein B", "entity_type": "GENE", "pos": [172, 186]}, {"entity": "beta 8", "entity_type": "GENE", "pos": [231, 237]}], "task": "NER"}
{"text": "Magnetic force and torque at 1 . 5 T did not dislodge the GF or result in perforation of canine IVC by the GF .", "entity": [], "task": "NER"}
{"text": "The rec8 ( + ) , rec10 ( + ) , and rec11 ( + ) genes of the fission yeast Schizosaccharomyces pombe exhibit similar specificities for meiotic recombination and rec8 ( + ) is required for sister chromatid cohesion and homolog pairing .", "entity": [{"entity": "rec8 ( + )", "entity_type": "GENE", "pos": [4, 14]}, {"entity": "rec10 ( + )", "entity_type": "GENE", "pos": [17, 28]}, {"entity": "rec11 ( + ) genes of the fission yeast Schizosaccharomyces pombe", "entity_type": "GENE", "pos": [35, 99]}, {"entity": "rec8 ( + )", "entity_type": "GENE", "pos": [160, 170]}], "task": "NER"}
{"text": "Synergistic induction of apoptosis in human leukemia cells ( U937 ) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC / MAPK cascade .", "entity": [{"entity": "PKC", "entity_type": "GENE", "pos": [163, 166]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [169, 173]}], "task": "NER"}
{"text": "The formation of a D - loop is an essential step in DNA double - strand break repair through recombination .", "entity": [], "task": "NER"}
{"text": "Using a set of sera for which full chlamydial micro - immunofluorescence results suggested a clear diagnosis , we have evaluated the Chlamydia Spot - IF test ( bioMerieux ) , which allows a comparison of titres to Chlamydia trachomatis and C . psittaci antigens .", "entity": [{"entity": "Chlamydia trachomatis and C . psittaci antigens", "entity_type": "GENE", "pos": [214, 261]}], "task": "NER"}
{"text": "ET - 1 limited the electrocardiographic evidence of subendocardial ischemia and attenuated contractile dysfunction compared with mechanical stenosis at the same coronary flows , even though lactate flux was similar .", "entity": [{"entity": "ET - 1", "entity_type": "GENE", "pos": [0, 6]}], "task": "NER"}
{"text": "The AtNMT1 expression profile indicated ubiquity in roots , stem , leaves , flowers , and siliques ( approximately 1 . 7 kb transcript and approximately 50 kDa immunoreactive polypeptide ) but a greater level in the younger tissue , which are developmentally very active .", "entity": [{"entity": "AtNMT1", "entity_type": "GENE", "pos": [4, 10]}], "task": "NER"}
{"text": "CONCLUSION : DMIPP detects regionally hypoperfused myocardium , in which agreement between MBF and fatty acid uptake deteriorates .", "entity": [], "task": "NER"}
{"text": "The majority of putative TSC2 mutations were found in sporadic rather than TSC2 - linked families .", "entity": [{"entity": "TSC2 mutations", "entity_type": "GENE", "pos": [25, 39]}, {"entity": "TSC2", "entity_type": "GENE", "pos": [75, 79]}], "task": "NER"}
{"text": "Thirty - three small glottic carcinomas ( T1 and small T2 ; UICC , 1978 ) were examined by malignancy grading using the 8 - factor system proposed by Jakobsson et al .", "entity": [], "task": "NER"}
{"text": "None of the 10 sequences has hitherto been recognized as part of the p53 signaling pathway .", "entity": [{"entity": "p53", "entity_type": "GENE", "pos": [69, 72]}], "task": "NER"}
{"text": "Studies in 26 patients .", "entity": [], "task": "NER"}
{"text": "Transfection of H chain loss variant myeloma with the complete 12 kb construct , termed 238H - Cmicro , resulted in secretion of intact Ig pairing 238H - Cmicro , with a lambda L chain ; however , transfectant Ig lacked autoreactivity and pathogenicity .", "entity": [{"entity": "H chain loss variant", "entity_type": "GENE", "pos": [16, 36]}, {"entity": "238H - Cmicro", "entity_type": "GENE", "pos": [88, 101]}, {"entity": "238H - Cmicro", "entity_type": "GENE", "pos": [147, 160]}, {"entity": "lambda L chain", "entity_type": "GENE", "pos": [170, 184]}, {"entity": "transfectant Ig", "entity_type": "GENE", "pos": [197, 212]}], "task": "NER"}
{"text": "Comparison of the genes coding for mouse and human p36 ( annexin II ) and mouse , rat and human p35 ( annexin I ) and pigeon cp35 ( an annexin I - related protein ) shows strong genomic structural conservation supporting the hypothesis that these genes had a common ancestor .", "entity": [{"entity": "p36", "entity_type": "GENE", "pos": [51, 54]}, {"entity": "annexin II", "entity_type": "GENE", "pos": [57, 67]}, {"entity": "p35", "entity_type": "GENE", "pos": [96, 99]}, {"entity": "annexin I", "entity_type": "GENE", "pos": [102, 111]}, {"entity": "cp35", "entity_type": "GENE", "pos": [125, 129]}, {"entity": "annexin I - related protein", "entity_type": "GENE", "pos": [135, 162]}], "task": "NER"}
{"text": "Now : pleasure in work", "entity": [], "task": "NER"}
{"text": "Cerumen management in hearing conservation : the Dallas ( Texas ) Independent School District program .", "entity": [], "task": "NER"}
{"text": "Mammalian homologues of the Polycomb - group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S . cerevisiae telomeres .", "entity": [{"entity": "Polycomb - group gene", "entity_type": "GENE", "pos": [28, 49]}, {"entity": "Enhancer of zeste", "entity_type": "GENE", "pos": [50, 67]}], "task": "NER"}
{"text": "Xanthoepocin , a new antibiotic from Penicillium simplicissimum IFO5762 .", "entity": [], "task": "NER"}
{"text": "Additionally , VAHS is often associated with fatal infectious mononucleosis ( IM ) .", "entity": [], "task": "NER"}
{"text": "In addition , mutations within the Ubx unit exons are known and most of these behave as null alleles .", "entity": [{"entity": "Ubx unit exons", "entity_type": "GENE", "pos": [35, 49]}], "task": "NER"}
{"text": "273 , 27420 - 27429 ) a putative peroxisome proliferator - activated receptor response element ( PPRE ) is present from - 458 to - 474 .", "entity": [], "task": "NER"}
{"text": "In T cells these two signal pathways are critical for interleukin - 2 production .", "entity": [{"entity": "interleukin - 2", "entity_type": "GENE", "pos": [54, 69]}], "task": "NER"}
{"text": "These results induce that the putative TATA box and initiator are not involved in the promoter activity , and that the vitronectin promoter lacks the TATA box , initiator and GC box .", "entity": [{"entity": "vitronectin promoter", "entity_type": "GENE", "pos": [119, 139]}], "task": "NER"}
{"text": "Both residues are conserved in the three phosphorylated paralogs but are absent in the ones that were not substrates of RsbT : YetI and YezB , each of which bears only one of the conserved residues ; and YtvA , which lacks both residues and instead possesses an N - terminal PAS domain .", "entity": [{"entity": "RsbT", "entity_type": "GENE", "pos": [120, 124]}, {"entity": "YetI", "entity_type": "GENE", "pos": [127, 131]}, {"entity": "YezB", "entity_type": "GENE", "pos": [136, 140]}, {"entity": "YtvA", "entity_type": "GENE", "pos": [204, 208]}, {"entity": "PAS", "entity_type": "GENE", "pos": [275, 278]}], "task": "NER"}
{"text": "The role of PORT in the treatment of N2 tumours is not clear and may justify further research .", "entity": [], "task": "NER"}
{"text": "The TDx assay for cyclosporine and its metabolites in blood samples compared with HPLC and RIA methods .", "entity": [], "task": "NER"}
{"text": "This is consistent with the need for a nuclear retinoid receptor function in RA - induced ERK2 activation .", "entity": [{"entity": "retinoid receptor", "entity_type": "GENE", "pos": [47, 64]}, {"entity": "ERK2", "entity_type": "GENE", "pos": [90, 94]}], "task": "NER"}
{"text": "It was previously shown that Vi antigen expression was regulated by a system similar to the rcs regulatory system involved in colanic acid synthesis in Escherichia coli .", "entity": [{"entity": "Vi antigen", "entity_type": "GENE", "pos": [29, 39]}, {"entity": "rcs", "entity_type": "GENE", "pos": [92, 95]}], "task": "NER"}
{"text": "However , the molecular mechanisms by which specific cis - and trans - acting factors control activity of the prodynorphin promoter are not as clearly defined .", "entity": [{"entity": "prodynorphin promoter", "entity_type": "GENE", "pos": [110, 131]}], "task": "NER"}
{"text": "The gene set in this mitochondrial genome is a subset of that of Reclinomonas americana , an amoeboid protozoan .", "entity": [], "task": "NER"}
{"text": "The library will thus be useful for the selection of cosmid clones which carry CDC genes from yeast by complementing first , with the vectorial yeast gene URA1 , the pyrimidine auxotrophy of most cdc - strains and then , with the respective CDC wild - type genes , of the temperature - sensitive mutant alleles .", "entity": [{"entity": "CDC genes from yeast", "entity_type": "GENE", "pos": [79, 99]}, {"entity": "yeast gene URA1", "entity_type": "GENE", "pos": [144, 159]}, {"entity": "cdc", "entity_type": "GENE", "pos": [196, 199]}, {"entity": "CDC wild - type genes", "entity_type": "GENE", "pos": [241, 262]}], "task": "NER"}
{"text": "A plasma cell - rich infiltrate was present in the connective tissue cores of the papillae .", "entity": [], "task": "NER"}
{"text": "Peptide competition studies have localized a cyclin A interaction site to a Lys381Lys382Leu383Met384Phe385 sequence within C - terminal negative regulatory domain of human p53 .", "entity": [{"entity": "cyclin A interaction site", "entity_type": "GENE", "pos": [45, 70]}, {"entity": "human p53", "entity_type": "GENE", "pos": [166, 175]}], "task": "NER"}
{"text": "A phase II study was initiated to evaluate the effect of a combination of the pure L - isomer of LV and 5 - FU along with epirubicin in patients with advanced pancreatic cancer .", "entity": [], "task": "NER"}
{"text": "Attenuated serum cortisol responses were found in six of the patients despite a normal ACTH test .", "entity": [{"entity": "ACTH", "entity_type": "GENE", "pos": [87, 91]}], "task": "NER"}
{"text": "While some still automatically refuse all patients with positive mediastinoscopy , most authors still remain very interventionistic for N2 patients selected on very accurate criteria that are analyzed above .", "entity": [], "task": "NER"}
{"text": "Inability of niacin to protect from in vivo hyperoxia or in vitro microsomal lipid peroxidation .", "entity": [], "task": "NER"}
{"text": "Sesame seed should also be considered a cause of allergic reactions to drug products and cosmetics .", "entity": [], "task": "NER"}
{"text": "In absence of i . m . medication , levels over 1 , 000 U must be carefully screened in order to rule out SNM or organic pathology associated .", "entity": [], "task": "NER"}
{"text": "A yeast mitochondrial translation initiation codon mutation affecting the gene for cytochrome oxidase subunit III ( COX3 ) was partially suppressed by a spontaneous nuclear mutation .", "entity": [{"entity": "cytochrome oxidase subunit III", "entity_type": "GENE", "pos": [83, 113]}, {"entity": "COX3", "entity_type": "GENE", "pos": [116, 120]}], "task": "NER"}
{"text": "Patients with endocarditis or vascular infection were more frequently immunocompromised and older than those with acute Q fever .", "entity": [], "task": "NER"}
{"text": "This latter complex reacts with an antibody to serum response factor ( SRF ) and exhibits the same binding characteristics as purified SRF .", "entity": [{"entity": "serum response factor", "entity_type": "GENE", "pos": [47, 68]}, {"entity": "SRF", "entity_type": "GENE", "pos": [71, 74]}, {"entity": "SRF", "entity_type": "GENE", "pos": [135, 138]}], "task": "NER"}
{"text": "MEASURES : SF - 36 questionnaires were completed by patients at both initial and discharge examinations .", "entity": [], "task": "NER"}
{"text": "Hormonal replacement therapy for women with a personal history of breast cancer ?", "entity": [], "task": "NER"}
{"text": "The human SHBG proximal promoter was analyzed by DNase I footprinting , and the functional significance of 6 footprinted regions ( FP1 - FP6 ) within the proximal promoter was studied in human HepG2 hepatoblastoma cells .", "entity": [{"entity": "human SHBG proximal promoter", "entity_type": "GENE", "pos": [4, 32]}, {"entity": "DNase I", "entity_type": "GENE", "pos": [49, 56]}], "task": "NER"}
{"text": "Endodontic treatment of deciduous teeth using the formocresol amputation method", "entity": [], "task": "NER"}
{"text": "The analysis of results suggests that seroprevalence of Lyme borreliosis in dogs of the Kosice region is not negligible .", "entity": [], "task": "NER"}
{"text": "Mutant beta2 - adrenergic receptors with a Tyr - to - Phe substitution at Tyr - 350 do not display agonist - induced desensitization , Src recruitment , or Src activation .", "entity": [{"entity": "beta2 - adrenergic receptors", "entity_type": "GENE", "pos": [7, 35]}, {"entity": "Src", "entity_type": "GENE", "pos": [135, 138]}, {"entity": "Src", "entity_type": "GENE", "pos": [156, 159]}], "task": "NER"}
{"text": "The feasibility of creating CR1 / Ig chimeras makes possible a new strategy of targeting complement inhibition by the use of Ig fusion partners having particular antigenic specificities .", "entity": [{"entity": "CR1", "entity_type": "GENE", "pos": [28, 31]}, {"entity": "Ig", "entity_type": "GENE", "pos": [34, 36]}, {"entity": "Ig fusion partners", "entity_type": "GENE", "pos": [125, 143]}], "task": "NER"}
{"text": "Otosclerosis in monozygotic twins : clinical and genetical analysis", "entity": [], "task": "NER"}
{"text": "The results show that in uninfected NIH - 3T3 cells Avarol ( i ) causes a 50 % reduction of the growth rate only at the high concentration of 29 . 6 microM and ( ii ) is accumulated in the cytoplasm close to the nucleus .", "entity": [], "task": "NER"}
{"text": "Furthermore , disruption of pcr1 reduced expression of fbp1 , a glucose - repressible gene negatively regulated by PKA .", "entity": [{"entity": "pcr1", "entity_type": "GENE", "pos": [28, 32]}, {"entity": "fbp1", "entity_type": "GENE", "pos": [55, 59]}, {"entity": "PKA", "entity_type": "GENE", "pos": [115, 118]}], "task": "NER"}
{"text": "This B - box is not present in ETS1 , ETS2 , PEA3 or PU . 1 and these proteins were unable to form ternary complexes with SRF and Egrl - SREs or c - fos SRE .", "entity": [{"entity": "ETS1", "entity_type": "GENE", "pos": [31, 35]}, {"entity": "ETS2", "entity_type": "GENE", "pos": [38, 42]}, {"entity": "PEA3", "entity_type": "GENE", "pos": [45, 49]}, {"entity": "PU . 1", "entity_type": "GENE", "pos": [53, 59]}, {"entity": "SRF", "entity_type": "GENE", "pos": [122, 125]}, {"entity": "Egrl", "entity_type": "GENE", "pos": [130, 134]}, {"entity": "c - fos", "entity_type": "GENE", "pos": [145, 152]}], "task": "NER"}
{"text": "Excretion of radiopharmaceuticals into breast milk .", "entity": [], "task": "NER"}
{"text": "It is concluded that the drinking ampules of VP - 16 - 213 can be replaced with the new oral capsules with a recommended initial dose of 100 - 130 mg / m2 given in 5 - day courses every 21 - 28 days .", "entity": [], "task": "NER"}
{"text": "Deletion of the region from amino acid residues 2 - 67 in E1A , which has been postulated to interact with p300 / CBP , also abolished the inhibitory effect of E1A , whereas deletion of the region from residues 120 to 140 had no effect .", "entity": [{"entity": "E1A", "entity_type": "GENE", "pos": [58, 61]}, {"entity": "p300", "entity_type": "GENE", "pos": [107, 111]}, {"entity": "CBP", "entity_type": "GENE", "pos": [114, 117]}, {"entity": "E1A", "entity_type": "GENE", "pos": [160, 163]}], "task": "NER"}
{"text": "It was found that on the 14th and 21st day after cimetidine administration serum gastrin levels were significantly elevated .", "entity": [{"entity": "serum gastrin", "entity_type": "GENE", "pos": [75, 88]}], "task": "NER"}
{"text": "Both PMP20 gene products contain the carboxyl - terminal sequence AKL , similar to the putative SKL peroxisomal sorting sequence ( Gould , S .", "entity": [{"entity": "PMP20 gene products", "entity_type": "GENE", "pos": [5, 24]}], "task": "NER"}
{"text": "After cumulative occlusions of 15 , 30 , 45 , and 90 min , transmural needle biopsies were taken from the ischemic area to be analyzed for adenine nucleotides , nucleosides , creatine phosphate , and ultrastructural changes .", "entity": [], "task": "NER"}
{"text": "We found both the v - Ras - and PC - PLC - transformed cells to be insensitive to stimulation with platelet - derived growth factor ( PDGF ) .", "entity": [{"entity": "v - Ras", "entity_type": "GENE", "pos": [18, 25]}, {"entity": "PC - PLC", "entity_type": "GENE", "pos": [32, 40]}, {"entity": "platelet - derived growth factor", "entity_type": "GENE", "pos": [99, 131]}, {"entity": "PDGF", "entity_type": "GENE", "pos": [134, 138]}], "task": "NER"}
{"text": "Although indomethacin is useful for examining the role of cyclooxygenase products in asthmatic responses , it should not be considered in the treatment of asthma .", "entity": [{"entity": "cyclooxygenase products", "entity_type": "GENE", "pos": [58, 81]}], "task": "NER"}
{"text": "Furthermore , it was found that the Shb - overexpressing cells extended neurites in response to epidermal growth factor .", "entity": [{"entity": "Shb", "entity_type": "GENE", "pos": [36, 39]}, {"entity": "epidermal growth factor", "entity_type": "GENE", "pos": [96, 119]}], "task": "NER"}
{"text": "Tre during exercise at 35 W at 23 degrees C correlated r = - 70 with Vo2max and r = 0 . 80 with Tre during exercise in heat .", "entity": [], "task": "NER"}
{"text": "Therapeutic iodine 125 for hyperthyroidism : evidence for a special radiobiological effect on the follicular cell .", "entity": [], "task": "NER"}
{"text": "The biological activity of these mutants was tested by determining their capacity to ( i ) reconstitute RNA polymerase activity in vivo by cotransfection with proteins NP , PB1 , and PA and a virion - like RNA encoding the cat gene into vaccinia virus T7 - infected COS - 1 cells and ( ii ) complete with the wild - type PB2 activity .", "entity": [{"entity": "RNA polymerase", "entity_type": "GENE", "pos": [104, 118]}, {"entity": "NP", "entity_type": "GENE", "pos": [168, 170]}, {"entity": "PB1", "entity_type": "GENE", "pos": [173, 176]}, {"entity": "PA", "entity_type": "GENE", "pos": [183, 185]}, {"entity": "cat", "entity_type": "GENE", "pos": [223, 226]}, {"entity": "wild - type PB2", "entity_type": "GENE", "pos": [309, 324]}], "task": "NER"}
{"text": "Should we use thiazide diuretics in hypertensive patients with non - insulin - dependent diabetes mellitus ?", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [69, 76]}], "task": "NER"}
{"text": "It appears that the K - ABC is a relatively nonbiased test suitable for the evaluation of both gifted and nongifted children regardless of race or gender .", "entity": [], "task": "NER"}
{"text": "The University of North Carolina caries risk assessment was conducted between 1986 and 1989 with 5000 children initially in grades 1 and 5 from low fluoride sites in South Carolina and Maine .", "entity": [], "task": "NER"}
{"text": "Treatment of cells for 10 min with TNF - alpha resulted in activation of p44 / 42 MAPK , p38 , and JNK .", "entity": [{"entity": "TNF - alpha", "entity_type": "GENE", "pos": [35, 46]}, {"entity": "p44 / 42", "entity_type": "GENE", "pos": [73, 81]}, {"entity": "p38", "entity_type": "GENE", "pos": [89, 92]}, {"entity": "JNK", "entity_type": "GENE", "pos": [99, 102]}], "task": "NER"}
{"text": "The coding region of nifA was determined using a translational lacZ fusion and by site - directed mutagenesis to identify which of four in frame AUG codons was used .", "entity": [{"entity": "nifA", "entity_type": "GENE", "pos": [21, 25]}, {"entity": "lacZ fusion", "entity_type": "GENE", "pos": [63, 74]}], "task": "NER"}
{"text": "In phase II studies , MDL 72 , 974A is proving to be a useful adjunct to conventional therapy .", "entity": [], "task": "NER"}
{"text": "A derived RA - resistant line , NT2 / D1 - R1 , is deficient in this activity and is co - resistant to cisplatin .", "entity": [], "task": "NER"}
{"text": "These studies reveal that CREM , a tissue - specific factor , is expressed and regulated by gonadotropins in the ovary , that the predominant CREM transcripts encode the repressor protein ICER , and that ICER is capable of inhibiting cAMP - induced expression of the inhibin alpha - subunit gene .", "entity": [{"entity": "CREM", "entity_type": "GENE", "pos": [26, 30]}, {"entity": "gonadotropins", "entity_type": "GENE", "pos": [92, 105]}, {"entity": "CREM", "entity_type": "GENE", "pos": [142, 146]}, {"entity": "repressor protein ICER", "entity_type": "GENE", "pos": [170, 192]}, {"entity": "ICER", "entity_type": "GENE", "pos": [204, 208]}, {"entity": "inhibin alpha - subunit gene", "entity_type": "GENE", "pos": [267, 295]}], "task": "NER"}
{"text": "A small molecule ILK inhibitor suppresses the phosphorylation of PKB at the Ser - 473 but not the Thr - 308 site in the PTEN mutant cells .", "entity": [{"entity": "ILK", "entity_type": "GENE", "pos": [17, 20]}, {"entity": "PKB", "entity_type": "GENE", "pos": [65, 68]}, {"entity": "PTEN", "entity_type": "GENE", "pos": [120, 124]}], "task": "NER"}
{"text": "Menstrual and lunar cycles .", "entity": [], "task": "NER"}
{"text": "Phenacetin nephritis", "entity": [], "task": "NER"}
{"text": "Both claR and car are expressed as monocistronic transcripts ; the level of transcript declined rapidly after 48h in complex media , but low sustained levels of both transcripts were observed in defined GSPG medium until 96h . claR and car were not significantly expressed in mutants disrupted in the ccaR gene , a regulatory gene that controls positively clavulanic acid and cephamycin biosynthesis .", "entity": [{"entity": "claR", "entity_type": "GENE", "pos": [5, 9]}, {"entity": "car", "entity_type": "GENE", "pos": [14, 17]}, {"entity": "claR", "entity_type": "GENE", "pos": [227, 231]}, {"entity": "car", "entity_type": "GENE", "pos": [236, 239]}, {"entity": "ccaR gene", "entity_type": "GENE", "pos": [301, 310]}], "task": "NER"}
{"text": "Viral complementary 15 S mRNA that directs the synthesis of N protein and hybridizes to the predicted N gene DNA has been identified in infected cell extracts .", "entity": [{"entity": "15 S mRNA", "entity_type": "GENE", "pos": [20, 29]}, {"entity": "N protein", "entity_type": "GENE", "pos": [60, 69]}, {"entity": "N gene", "entity_type": "GENE", "pos": [102, 108]}], "task": "NER"}
{"text": "Experiments were performed without polarization or with cathodic and anodic polarization of the adsorbent .", "entity": [], "task": "NER"}
{"text": "Our results suggest that Sp1 binding site can function as a distinct TGF - beta responsive element for TGF - beta mediated promoter expression and Sp1 per se can mediate this response .", "entity": [{"entity": "Sp1 binding site", "entity_type": "GENE", "pos": [25, 41]}, {"entity": "TGF - beta responsive element", "entity_type": "GENE", "pos": [69, 98]}, {"entity": "TGF - beta", "entity_type": "GENE", "pos": [103, 113]}, {"entity": "Sp1", "entity_type": "GENE", "pos": [147, 150]}], "task": "NER"}
{"text": "A positive correlation was also established between the level of FP9C binding and the degree of cell differentiation in vitro .", "entity": [{"entity": "FP9C", "entity_type": "GENE", "pos": [65, 69]}], "task": "NER"}
{"text": "In another patient , IRPF recurred in the ureter of a living related renal graft 6 months after transplantation .", "entity": [], "task": "NER"}
{"text": "Similar to the D , B / B ' and E proteins , the F and G proteins do not possess any of the known RNA binding motifs , suggesting that other types of RNA - protein interactions occur in the snRNP core .", "entity": [{"entity": "D", "entity_type": "GENE", "pos": [15, 16]}, {"entity": "B", "entity_type": "GENE", "pos": [19, 20]}, {"entity": "B '", "entity_type": "GENE", "pos": [23, 26]}, {"entity": "E proteins", "entity_type": "GENE", "pos": [31, 41]}, {"entity": "F", "entity_type": "GENE", "pos": [48, 49]}, {"entity": "G proteins", "entity_type": "GENE", "pos": [54, 64]}], "task": "NER"}
{"text": "Ultrasound - guided fine - needle aspiration biopsy ( US - FNAB ) revealed normal - looking squamous cells .", "entity": [], "task": "NER"}
{"text": "HC - toxin exerts a potent cytostatic effect on plant and animal cells by inhibiting histone deacetylase .", "entity": [{"entity": "HC - toxin", "entity_type": "GENE", "pos": [0, 10]}, {"entity": "histone deacetylase", "entity_type": "GENE", "pos": [85, 104]}], "task": "NER"}
{"text": "In EGF receptor - mediated signaling , the protein kinase PKB / Akt and the mitogen - activated protein kinase c - Jun N - terminal kinase , but not extracellular signal - regulated kinase 2 , function downstream of phosphatidylinositol 3 - kinase ( PI 3 - kinase ) .", "entity": [{"entity": "EGF receptor", "entity_type": "GENE", "pos": [3, 15]}, {"entity": "protein kinase PKB", "entity_type": "GENE", "pos": [43, 61]}, {"entity": "Akt", "entity_type": "GENE", "pos": [64, 67]}, {"entity": "mitogen - activated protein kinase c - Jun N - terminal kinase", "entity_type": "GENE", "pos": [76, 138]}, {"entity": "extracellular signal - regulated kinase 2", "entity_type": "GENE", "pos": [149, 190]}, {"entity": "phosphatidylinositol 3 - kinase", "entity_type": "GENE", "pos": [216, 247]}, {"entity": "PI 3 - kinase", "entity_type": "GENE", "pos": [250, 263]}], "task": "NER"}
{"text": "Blockade of T cell activation using a surface - linked single - chain antibody to CTLA - 4 ( CD152 ) .", "entity": [{"entity": "CTLA - 4", "entity_type": "GENE", "pos": [82, 90]}, {"entity": "CD152", "entity_type": "GENE", "pos": [93, 98]}], "task": "NER"}
{"text": "On the basis of this homology , we examined the potential role of c - Rel in controlling IL - 2R alpha transcription .", "entity": [{"entity": "c - Rel", "entity_type": "GENE", "pos": [66, 73]}, {"entity": "IL - 2R alpha", "entity_type": "GENE", "pos": [89, 102]}], "task": "NER"}
{"text": "Site - directed mutagenesis shows that sites throughout the IRE alter negative control and IRE - BP binding reflecting the fact that the footprint of the IRE - BP is over the entire IRE .", "entity": [{"entity": "IRE", "entity_type": "GENE", "pos": [60, 63]}, {"entity": "IRE - BP", "entity_type": "GENE", "pos": [91, 99]}, {"entity": "IRE - BP", "entity_type": "GENE", "pos": [154, 162]}, {"entity": "IRE", "entity_type": "GENE", "pos": [182, 185]}], "task": "NER"}
{"text": "However , LXRalpha inhibited binding of PPARalpha / RXRalpha heterodimers to PPREs , and coexpression of LXRalpha in mammalian cells antagonized peroxisome proliferator signaling mediated by PPARalpha / RXRalpha in vivo .", "entity": [{"entity": "LXRalpha", "entity_type": "GENE", "pos": [10, 18]}, {"entity": "PPARalpha", "entity_type": "GENE", "pos": [40, 49]}, {"entity": "RXRalpha", "entity_type": "GENE", "pos": [52, 60]}, {"entity": "LXRalpha", "entity_type": "GENE", "pos": [105, 113]}, {"entity": "PPARalpha", "entity_type": "GENE", "pos": [191, 200]}, {"entity": "RXRalpha", "entity_type": "GENE", "pos": [203, 211]}], "task": "NER"}
{"text": "In clinical stroke cardiovascular abnormalities are frequently neglected although they occur more often than it is generally assumed .", "entity": [], "task": "NER"}
{"text": "Complementary DNA libraries from liver and ovary of an immature female channel catfish were screened with a homologous ERalpha cDNA probe .", "entity": [{"entity": "homologous ERalpha cDNA", "entity_type": "GENE", "pos": [108, 131]}], "task": "NER"}
{"text": "Examination of the Coomassie - stained gels revealed that the capsid - like particles composed of the N11 - VP1 protein did not contain any host - derived histones .", "entity": [{"entity": "N11 - VP1", "entity_type": "GENE", "pos": [102, 111]}, {"entity": "histones", "entity_type": "GENE", "pos": [155, 163]}], "task": "NER"}
{"text": "Here we show that one nudF suppressor also suppresses hs - mutations in nudA , nudC , and nudG and deletions in nudA and nudF .", "entity": [{"entity": "nudF suppressor", "entity_type": "GENE", "pos": [22, 37]}, {"entity": "nudA", "entity_type": "GENE", "pos": [72, 76]}, {"entity": "nudC", "entity_type": "GENE", "pos": [79, 83]}, {"entity": "nudG", "entity_type": "GENE", "pos": [90, 94]}, {"entity": "nudA", "entity_type": "GENE", "pos": [112, 116]}, {"entity": "nudF", "entity_type": "GENE", "pos": [121, 125]}], "task": "NER"}
{"text": "Thus , the potential induction of this gene rearrangement by E1A gene therapy is unlikely to be clinically significant in the treatment of advanced malignant disease .", "entity": [{"entity": "E1A gene", "entity_type": "GENE", "pos": [61, 69]}], "task": "NER"}
{"text": "Our results suggest that Bry1 / Skn7 can influence the expression of MCB - and SCB - driven gene expression in budding yeast , perhaps including genes involved in cell wall metabolism , via a two - component signal transduction pathway which activates Bry1 / Skn7 in response to an unidentified signal .", "entity": [{"entity": "Bry1", "entity_type": "GENE", "pos": [25, 29]}, {"entity": "Skn7", "entity_type": "GENE", "pos": [32, 36]}, {"entity": "Bry1", "entity_type": "GENE", "pos": [252, 256]}, {"entity": "Skn7", "entity_type": "GENE", "pos": [259, 263]}], "task": "NER"}
{"text": "Buspirone therapy for Type A behavior , hostility , and perceived stress in cardiac patients .", "entity": [], "task": "NER"}
{"text": "When furA alone was introduced into the Delta ( furA - katG ) mutant , survival in mouse lungs was moderately increased , suggesting that FurA could regulate genes , other than katG , that are involved in pathogenesis .", "entity": [{"entity": "furA", "entity_type": "GENE", "pos": [5, 9]}, {"entity": "furA", "entity_type": "GENE", "pos": [48, 52]}, {"entity": "katG", "entity_type": "GENE", "pos": [55, 59]}, {"entity": "FurA", "entity_type": "GENE", "pos": [138, 142]}, {"entity": "katG", "entity_type": "GENE", "pos": [177, 181]}], "task": "NER"}
{"text": "The resulting threshold elevation curves fell into a small number of distinct groups , suggesting the existence of discrete spatial frequency mechanisms in human central vision .", "entity": [], "task": "NER"}
{"text": "Through interactions with the pre - mRNA and the CTD domain of the Polymerase II , SR proteins have been shown to regulate alternative splicing .", "entity": [{"entity": "Polymerase II", "entity_type": "GENE", "pos": [67, 80]}, {"entity": "SR proteins", "entity_type": "GENE", "pos": [83, 94]}], "task": "NER"}
{"text": "The screen identifies mutants whose growth depends on high levels of expression of that gene .", "entity": [], "task": "NER"}
{"text": "Electrophoretic mobility shift analysis of protein - DNA complexes formed with nuclear proteins isolated from I3C - treated and - untreated cells , in combination with supershift assays using Sp1 antibodies , demonstrated that the Sp1 - binding site in the CDK6 promoter forms a specific I3C - responsive DNA - protein complex that contains the Sp1 transcription factor .", "entity": [{"entity": "Sp1 antibodies", "entity_type": "GENE", "pos": [192, 206]}, {"entity": "Sp1 - binding site", "entity_type": "GENE", "pos": [231, 249]}, {"entity": "CDK6 promoter", "entity_type": "GENE", "pos": [257, 270]}, {"entity": "Sp1 transcription factor", "entity_type": "GENE", "pos": [345, 369]}], "task": "NER"}
{"text": "It is suggested that the mechanism of intestinal absorption of vitamin D and 25 - hydroxy - vitamin D may differ in man , the absorption of 25 - hydroxy - vitamin D possibly being less dependent on bile acids .", "entity": [], "task": "NER"}
{"text": "In a study in Singapore , Chinese , Malay and Indian patients with pulmonary tuberculosis received 2 months of daily treatment with streptomycin , isoniazid , rifampicin , and pyrazinamide followed by daily isoniazid , and rifampicin either with pyrazinamide ( SHRZ / HRZ ) or without it ( SHRZ / HR ) , allocated at random .", "entity": [], "task": "NER"}
{"text": "However , C / EBP beta stimulated transcription primarily through the cAMP - responsive element ( CRE ) , which maps between positions - 77 to - 94 , but not at the more 5 ' - binding sites .", "entity": [{"entity": "C / EBP beta", "entity_type": "GENE", "pos": [10, 22]}], "task": "NER"}
{"text": "Helenalin triggers a CD95 death receptor - independent apoptosis that is not affected by overexpression of Bcl - x ( L ) or Bcl - 2 .", "entity": [{"entity": "CD95 death receptor", "entity_type": "GENE", "pos": [21, 40]}, {"entity": "Bcl - x ( L )", "entity_type": "GENE", "pos": [107, 120]}, {"entity": "Bcl - 2", "entity_type": "GENE", "pos": [124, 131]}], "task": "NER"}
{"text": "The observed alterations in lung functions in these subjects indicate that individuals performing heavy continuous exercise are more likely to be affected by lower O3 levels .", "entity": [], "task": "NER"}
{"text": "Shields needed for pacemakers .", "entity": [], "task": "NER"}
{"text": "A nationwide record linkage of the Finnish Twin Cohort Study ( FTCS ) with the Hospital Discharge Registry and the Registry of Rights for Free medication is presented .", "entity": [], "task": "NER"}
{"text": "Results demonstrated that for both S . europaea and A . prostrata , the total number of seeds that germinated decreased throughout the growing season .", "entity": [], "task": "NER"}
{"text": "A personal view of future trends in the field of immunoassay concludes this review .", "entity": [], "task": "NER"}
{"text": "Our results admit that a ribosome scanning mechanism of the MP gene expression from I ( 2 ) sgRNA operates concurrently .", "entity": [{"entity": "MP gene", "entity_type": "GENE", "pos": [60, 67]}], "task": "NER"}
{"text": "This study demonstrates that Fluosol significantly attenuates neutrophil adherence , cytotoxicity , and enzyme release in an in vitro model of microvascular injury .", "entity": [], "task": "NER"}
{"text": "22 . 6 % of patients were found to be positive at histology in the corpus mucosa ; all but one of these patients had elevated circulating IgG to H . pylori ( Group C ) .", "entity": [{"entity": "IgG", "entity_type": "GENE", "pos": [138, 141]}], "task": "NER"}
{"text": "Concerning the practical approach in a clinical setting , it has to be pointed out that with these diseases a hepatitis C infection has to be considered and testing for hepatitis C antibodies and , if positive , hepatitis C - RNA is indicated .", "entity": [{"entity": "hepatitis C antibodies", "entity_type": "GENE", "pos": [169, 191]}, {"entity": "hepatitis C - RNA", "entity_type": "GENE", "pos": [212, 229]}], "task": "NER"}
{"text": "In order to investigate the effect of the local direct action of danazol upon endometriosis , intravaginal and intrauterine application were tried .", "entity": [], "task": "NER"}
{"text": "Western blot experiments detected SMBP as a 70 kDa protein that may be further cleaved into an active 34 kDa N - terminal polypeptide .", "entity": [{"entity": "SMBP", "entity_type": "GENE", "pos": [34, 38]}], "task": "NER"}
{"text": "80 bp ) surrounding the site of transcription initiation .", "entity": [], "task": "NER"}
{"text": "A backward look at urinary tract infections .", "entity": [], "task": "NER"}
{"text": "All the cognate gene clones were constructed , using either PCR products amplified from genomic DNA , or gap - repair .", "entity": [], "task": "NER"}
{"text": "On Western blots , the same antibodies recognized the recombinant protein migrating slightly slower on SDS / PAGE than chicken axonin - 1 .", "entity": [{"entity": "chicken axonin - 1", "entity_type": "GENE", "pos": [119, 137]}], "task": "NER"}
{"text": "BCR - ABL elicits transformation of both fibroblast and hematopoietic cells and blocks apoptosis following cytokine deprivation in various factor - dependent cells .", "entity": [{"entity": "BCR", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "ABL", "entity_type": "GENE", "pos": [6, 9]}], "task": "NER"}
{"text": "The transcriptional transactivator ( Tas ) of simian foamy virus type 1 strongly augments gene expression directed by both the promoter in the viral long terminal repeat and the newly discovered internal promoter located within the env gene .", "entity": [{"entity": "transcriptional transactivator", "entity_type": "GENE", "pos": [4, 34]}, {"entity": "Tas", "entity_type": "GENE", "pos": [37, 40]}, {"entity": "env gene", "entity_type": "GENE", "pos": [232, 240]}], "task": "NER"}
{"text": "Analysis of nt sequence was carried out on three out of the more than 15 of these regions present in the mouse genome .", "entity": [], "task": "NER"}
{"text": "Moreover , site - specific integration of the ITR - flanked DNA was also detected by PCR amplification of the ITR - aavs1 junction in transduced human fibroblasts .", "entity": [{"entity": "ITR - aavs1 junction", "entity_type": "GENE", "pos": [110, 130]}], "task": "NER"}
{"text": "Finally , we demonstrate that animals carrying a snf mutation that converts SNF from a bifunctional protein to a U1 snRNP - specific protein are viable .", "entity": [{"entity": "snf", "entity_type": "GENE", "pos": [49, 52]}, {"entity": "SNF", "entity_type": "GENE", "pos": [76, 79]}, {"entity": "U1 snRNP - specific protein", "entity_type": "GENE", "pos": [113, 140]}], "task": "NER"}
{"text": "For this interaction , the C - terminal part of Sp1 and the N terminus of E2F1 , a domain also present in E2F2 and E2F3 but absent in E2F4 and E2F5 , were essential .", "entity": [{"entity": "Sp1", "entity_type": "GENE", "pos": [48, 51]}, {"entity": "E2F1", "entity_type": "GENE", "pos": [74, 78]}, {"entity": "E2F2", "entity_type": "GENE", "pos": [106, 110]}, {"entity": "E2F3", "entity_type": "GENE", "pos": [115, 119]}, {"entity": "E2F4", "entity_type": "GENE", "pos": [134, 138]}, {"entity": "E2F5", "entity_type": "GENE", "pos": [143, 147]}], "task": "NER"}
{"text": "To gain additional insights into this novel apoptotic checkpoint , we have now characterized the mouse survivin locus .", "entity": [{"entity": "mouse survivin locus", "entity_type": "GENE", "pos": [97, 117]}], "task": "NER"}
{"text": "Since RIP140 generally down - regulates receptor activity in mammalian cells and specifically down - regulates coactivation mediated by SRC - 1 , we propose a model in which RIP140 indirectly regulates nuclear receptor AF - 2 activity by competition for coactivators such as SRC - 1 .", "entity": [{"entity": "RIP140", "entity_type": "GENE", "pos": [6, 12]}, {"entity": "SRC - 1", "entity_type": "GENE", "pos": [136, 143]}, {"entity": "RIP140", "entity_type": "GENE", "pos": [174, 180]}, {"entity": "nuclear receptor AF - 2", "entity_type": "GENE", "pos": [202, 225]}, {"entity": "SRC - 1", "entity_type": "GENE", "pos": [275, 282]}], "task": "NER"}
{"text": "We constructed a stable , doubly transfected cell line ( TIS - 10 ) carrying a chromosomally integrated ptetO7 - CMV - L reporter construct and expressing the TetR - KRAB protein .", "entity": [{"entity": "ptetO7 - CMV - L", "entity_type": "GENE", "pos": [104, 120]}, {"entity": "TetR", "entity_type": "GENE", "pos": [159, 163]}, {"entity": "KRAB", "entity_type": "GENE", "pos": [166, 170]}], "task": "NER"}
{"text": "Value of bone scintigraphy with Tc99MDP in the early diagnosis of mobilization of the total hip prosthesis", "entity": [], "task": "NER"}
{"text": "Coimmunoprecipitation analysis suggests that these residues likely contribute to the multimerization function required for homomeric complex formation or heteromeric complex formation with p50 in that no association of p65 delta with itself or with p50 was evident .", "entity": [{"entity": "p50", "entity_type": "GENE", "pos": [189, 192]}, {"entity": "p65 delta", "entity_type": "GENE", "pos": [219, 228]}, {"entity": "p50", "entity_type": "GENE", "pos": [249, 252]}], "task": "NER"}
{"text": "The isolation of crt5 - 262 , an additional cdc allele of POL1 / CDC17 , suggests for the first time that directly blocking DNA replication can provide a signal to induce the DNA damage response . crt2 mutants show a defect in basal level expression of RNR1 - lacZ reporter constructs .", "entity": [{"entity": "crt5 - 262", "entity_type": "GENE", "pos": [17, 27]}, {"entity": "cdc allele", "entity_type": "GENE", "pos": [44, 54]}, {"entity": "POL1", "entity_type": "GENE", "pos": [58, 62]}, {"entity": "CDC17", "entity_type": "GENE", "pos": [65, 70]}, {"entity": "crt2 mutants", "entity_type": "GENE", "pos": [197, 209]}, {"entity": "RNR1", "entity_type": "GENE", "pos": [253, 257]}, {"entity": "lacZ", "entity_type": "GENE", "pos": [260, 264]}], "task": "NER"}
{"text": "Denaturing gradient gel electrophoresis ( DGGE ) with sequence analysis showed that PGCL4 is a major member in the female mammary gland , and in the submaxillary and lachrymal glands of both sexes , while the counterpart in male liver and the coagulate glands was found to be PGCL1 .", "entity": [{"entity": "PGCL4", "entity_type": "GENE", "pos": [84, 89]}, {"entity": "PGCL1", "entity_type": "GENE", "pos": [276, 281]}], "task": "NER"}
{"text": "Five sequence variants were identified .", "entity": [], "task": "NER"}
{"text": "If failure to solve invisible displacements was due to increased memory requirements , then the primates should perform at chance level on all 3 problems .", "entity": [], "task": "NER"}
{"text": "Mouse GRK6 - C displays none of these motifs .", "entity": [{"entity": "Mouse GRK6 - C", "entity_type": "GENE", "pos": [0, 14]}], "task": "NER"}
{"text": "The cumulative length of the RGSV genome , including RNAs 5 and 6 , was 25142 nt .", "entity": [], "task": "NER"}
{"text": "CTDK1 and CTDK2 also differ in their protein substrate specificity .", "entity": [{"entity": "CTDK1", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "CTDK2", "entity_type": "GENE", "pos": [10, 15]}], "task": "NER"}
{"text": "ATF is formulated from the prothrombin time ( PT ) , fibrinogen transformation rate ( FTR ) ( a representation of thrombin activity ) , and a consideration of the fibrinogen ( FBG ) content of blood plasma .", "entity": [{"entity": "prothrombin", "entity_type": "GENE", "pos": [27, 38]}, {"entity": "fibrinogen", "entity_type": "GENE", "pos": [53, 63]}, {"entity": "thrombin", "entity_type": "GENE", "pos": [114, 122]}, {"entity": "fibrinogen", "entity_type": "GENE", "pos": [163, 173]}, {"entity": "FBG", "entity_type": "GENE", "pos": [176, 179]}], "task": "NER"}
{"text": "Protease digestion and alkaline extraction of microsomes containing labeled mutant proteins further showed that segment 3 was sufficient for stable membrane anchoring of the glycoproteins , indicating that this segment may specify the transmembrane domain of the gB glycoprotein .", "entity": [{"entity": "gB glycoprotein", "entity_type": "GENE", "pos": [263, 278]}], "task": "NER"}
{"text": "Peripheral visual acuity with monovision and other contact lens corrections for presbyopia .", "entity": [], "task": "NER"}
{"text": "ORF3 appears to encode the homologue of the well - conserved proteasomal 26S regulatory subunit .", "entity": [{"entity": "proteasomal 26S regulatory subunit", "entity_type": "GENE", "pos": [61, 95]}], "task": "NER"}
{"text": "87 , 7270 - 7274 ) .", "entity": [], "task": "NER"}
{"text": "Protein binding to UAS1MLS1 was observed with extracts from derepressed but not from repressed cells , and could be competed for by an excess of the unlabelled CSRE ( ICL1 ) sequence .", "entity": [{"entity": "UAS1MLS1", "entity_type": "GENE", "pos": [19, 27]}, {"entity": "ICL1", "entity_type": "GENE", "pos": [167, 171]}], "task": "NER"}
{"text": "This inhibition was due to competition from the EMC virus IRES present in pEP - 2A transcripts , as well as the expression of proteolytically active 2Apro .", "entity": [{"entity": "pEP - 2A transcripts", "entity_type": "GENE", "pos": [74, 94]}, {"entity": "2Apro", "entity_type": "GENE", "pos": [149, 154]}], "task": "NER"}
{"text": "These properties prompted us to investigate Ets - 1 expression in 32 human astroglial tumors of WHO grades I - IV and to correlate the data with the expression pattern of VEGF , Flt - 1 , and KDR .", "entity": [{"entity": "Ets - 1", "entity_type": "GENE", "pos": [44, 51]}, {"entity": "VEGF", "entity_type": "GENE", "pos": [171, 175]}, {"entity": "Flt - 1", "entity_type": "GENE", "pos": [178, 185]}, {"entity": "KDR", "entity_type": "GENE", "pos": [192, 195]}], "task": "NER"}
{"text": "The CydDC system appears to be the first prokaryotic example of a heterodimeric ABC transport system in which each polypeptide contains both hydrophobic and ATP - binding domains .", "entity": [{"entity": "CydDC system", "entity_type": "GENE", "pos": [4, 16]}, {"entity": "heterodimeric ABC transport system", "entity_type": "GENE", "pos": [66, 100]}], "task": "NER"}
{"text": "Ionic composition ( Na + , K + , Ca + 2 , and Mg2 + ) of cerebrospinal fluid and feeding behavior in sheep .", "entity": [], "task": "NER"}
{"text": "Recently we have performed a detailed analysis of specific neuronal populations affected by the mutation which shed new light on the role of Krox - 20 in the segmentation and on the physiological consequences of its inactivation .", "entity": [{"entity": "Krox - 20", "entity_type": "GENE", "pos": [141, 150]}], "task": "NER"}
{"text": "Comparison of the sequences of the alpha - like DNA polymerases including E . coli DNA polymerase II showed that there were nine highly conserved regions , and we constructed an unrooted phylogenetic tree of the DNA polymerases based on the differences in these conserved regions .", "entity": [{"entity": "alpha - like DNA polymerases", "entity_type": "GENE", "pos": [35, 63]}, {"entity": "E . coli DNA polymerase II", "entity_type": "GENE", "pos": [74, 100]}, {"entity": "DNA polymerases", "entity_type": "GENE", "pos": [212, 227]}], "task": "NER"}
{"text": "Guanylyl cyclase C , the apparent guanylin receptor , was found in abundant amounts in the intestine by Northern analysis , and by the polymerase chain reaction or cDNA cloning it was also found in adrenal gland , airway epithelial cells , brain , and olfactory and tracheal mucosa .", "entity": [{"entity": "Guanylyl cyclase C", "entity_type": "GENE", "pos": [0, 18]}, {"entity": "guanylin receptor", "entity_type": "GENE", "pos": [34, 51]}], "task": "NER"}
{"text": "Older females had lumbar ( 0 . 6 + / - 1 . 3 ) and TB ( 1 . 1 + / - 1 . 1 ) BMD Z scores greater than 0 ( both , p < 0 . 001 ) .", "entity": [], "task": "NER"}
{"text": "Mutation of the distal E2F binding site in the cdc25A promoter abolished E2 - induced repression , whereas mutation of the proximal E2F site or the E2 site had no effect .", "entity": [{"entity": "E2F binding site", "entity_type": "GENE", "pos": [23, 39]}, {"entity": "cdc25A promoter", "entity_type": "GENE", "pos": [47, 62]}, {"entity": "E2", "entity_type": "GENE", "pos": [73, 75]}, {"entity": "E2F site", "entity_type": "GENE", "pos": [132, 140]}, {"entity": "E2 site", "entity_type": "GENE", "pos": [148, 155]}], "task": "NER"}
{"text": "Psychopathological , vegetative , and vital parameters were assessed every hour .", "entity": [], "task": "NER"}
{"text": "A new family of rate - adaptive pacemakers accomplishes this circadian rate variation by modeling the patient ' s sleep - wake cycle using a time - of - day clock inside the device .", "entity": [], "task": "NER"}
{"text": "New strategies are needed to prevent coronary rethrombosis in patients with minimal atherosclerosis after thrombolytic therapy for acute myocardial infarction .", "entity": [], "task": "NER"}
{"text": "METHODS AND RESULTS : With an array of 112 unipole , epicardial maps of electrically induced AF in 6 dogs ( acute group ) , self - sustained AF in 6 dogs ( chronic group ) , and sinus rhythm and atrial pacing in 3 dogs ( control group ) were analyzed before and after creating linear radiofrequency ablation lesions in both atria that eliminated the AF .", "entity": [], "task": "NER"}
{"text": "The mitochondrial tyrosyl - tRNA synthetase of Podospora anserina is a bifunctional enzyme active in protein synthesis and RNA splicing .", "entity": [{"entity": "mitochondrial tyrosyl - tRNA synthetase", "entity_type": "GENE", "pos": [4, 43]}], "task": "NER"}
{"text": "We found that the central nonconserved region of the large subunit is not essential for function and likely acts as a spacer between the conserved N - and C - terminal regions .", "entity": [], "task": "NER"}
{"text": "Further comparative analysis identified an ADNP paralog ( 33 % identity and 46 % similarity ) , indicating that these genes belong to a novel protein family with a nine - zinc finger motif followed by a homeobox domain .", "entity": [{"entity": "ADNP", "entity_type": "GENE", "pos": [43, 47]}], "task": "NER"}
{"text": "Surprisingly , apo - iso - 1 - cytochrome c is absent in cyc3 - strains , although apo - iso - 2 - cytochrome c is present at approximately the same level at which holo - iso - 2 - cytochrome c is found in CYC3 + strains .", "entity": [{"entity": "apo - iso - 1 - cytochrome c", "entity_type": "GENE", "pos": [15, 43]}, {"entity": "cyc3 -", "entity_type": "GENE", "pos": [57, 63]}, {"entity": "apo - iso - 2 - cytochrome c", "entity_type": "GENE", "pos": [83, 111]}, {"entity": "holo - iso - 2 - cytochrome c", "entity_type": "GENE", "pos": [164, 193]}, {"entity": "CYC3 +", "entity_type": "GENE", "pos": [206, 212]}], "task": "NER"}
{"text": "A role for phosphatidylinositol 3 - kinase in the regulation of beta 1 integrin activity by the CD2 antigen .", "entity": [{"entity": "phosphatidylinositol 3 - kinase", "entity_type": "GENE", "pos": [11, 42]}, {"entity": "beta 1 integrin", "entity_type": "GENE", "pos": [64, 79]}, {"entity": "CD2", "entity_type": "GENE", "pos": [96, 99]}], "task": "NER"}
{"text": "The cluster was mapped to nucleotides - 464 to - 434 ( relative to nucleotide A in the initiation codon ) in genomic DNA .", "entity": [], "task": "NER"}
{"text": "All the previously mapped structural protein - encoding genes of phage LL - H were included in the sequence .", "entity": [], "task": "NER"}
{"text": "An exception is the Bcl - 6 gene , encoding a transcription factor , which was found to be mutated in normal human memory B cells .", "entity": [{"entity": "Bcl - 6 gene", "entity_type": "GENE", "pos": [20, 32]}], "task": "NER"}
{"text": "Nature and incidence of conditioned responses in a methadone population : a comparison of laboratory , clinic , and naturalistic settings .", "entity": [], "task": "NER"}
{"text": "Serum PRL concentrations significantly increased after MCP administration in normal women , hyperprolactinemic patients with normal sella and patients with microadenoma , but not in macroadenoma patients with and without suprasellar expansion ( SSE ) .", "entity": [{"entity": "PRL", "entity_type": "GENE", "pos": [6, 9]}], "task": "NER"}
{"text": "Fourteen Centers participated in this trial .", "entity": [], "task": "NER"}
{"text": "In cells stably transfected with G alpha i - 2 or G alpha i - 3 gene 5 ' - flanking sequences fused to firefly luciferase cDNA reporter , temporal 10 - 15 - fold transcriptional activation of both genes occurred before cellular polarization .", "entity": [{"entity": "G alpha i - 2", "entity_type": "GENE", "pos": [33, 46]}, {"entity": "G alpha i - 3 gene", "entity_type": "GENE", "pos": [50, 68]}, {"entity": "luciferase", "entity_type": "GENE", "pos": [111, 121]}], "task": "NER"}
{"text": "A gene ( FMR - 1 ) was identified within a four cosmid contig of YAC DNA that expresses a 4 . 8 kb message in human brain .", "entity": [{"entity": "FMR - 1", "entity_type": "GENE", "pos": [9, 16]}], "task": "NER"}
{"text": "These include not only antioxidants , N - methyl - D - aspartate receptor antagonists , inhibitors of glutamate release , calcium channel blockers , polyamine antagonists , and nitric oxide synthase inhibitors , but cannabinoids , aspirin , melatonin , and vitamin B - 12 .", "entity": [{"entity": "N - methyl - D - aspartate receptor", "entity_type": "GENE", "pos": [38, 73]}, {"entity": "nitric oxide synthase", "entity_type": "GENE", "pos": [177, 198]}], "task": "NER"}
{"text": "In conclusion , ANH had no negative effects on the endocrine stress response during orthopedic surgery under epidural anesthesia .", "entity": [], "task": "NER"}
{"text": "Both genes ARO3 and ARO4 are strongly regulated under the general control regulatory system .", "entity": [{"entity": "genes ARO3", "entity_type": "GENE", "pos": [5, 15]}, {"entity": "ARO4", "entity_type": "GENE", "pos": [20, 24]}], "task": "NER"}
{"text": "Calculation of energy levels , E1 transition amplitudes , and parity violation in francium .", "entity": [], "task": "NER"}
{"text": "A homologue of the MAP / ERK family of protein kinase genes is expressed in vegetative and in female reproductive organs of Petunia hybrida .", "entity": [{"entity": "MAP", "entity_type": "GENE", "pos": [19, 22]}, {"entity": "ERK", "entity_type": "GENE", "pos": [25, 28]}], "task": "NER"}
{"text": "Significance of esophagocardiac reflexes for inducing thoracic pain", "entity": [], "task": "NER"}
{"text": "Northern blot analysis confirmed that ADAMTS - 1 was up - regulated in both metaphyseal ( 14 - to 35 - fold ) and diaphyseal ( 4 . 2 - fold ) bone 1 h after PTH - ( 1 - 38 ) injection and returned to control levels by 24 h .", "entity": [{"entity": "ADAMTS - 1", "entity_type": "GENE", "pos": [38, 48]}, {"entity": "PTH - ( 1 - 38 )", "entity_type": "GENE", "pos": [157, 173]}], "task": "NER"}
{"text": "The findings in the human multiple myeloma cell lines represent the first examples of B cells with downregulated PU . 1 expression and apparently contradict observations in the murine system in which PU . 1 is expressed and active in plasmacytoma cell lines .", "entity": [{"entity": "PU . 1", "entity_type": "GENE", "pos": [113, 119]}, {"entity": "PU . 1", "entity_type": "GENE", "pos": [200, 206]}], "task": "NER"}
{"text": "Northern blot analysis identified retina - specific transcripts of 3 . 0 kb for rod G alpha t and 2 . 6 kb for cone G alpha t .", "entity": [{"entity": "rod G alpha t", "entity_type": "GENE", "pos": [80, 93]}, {"entity": "cone G alpha t", "entity_type": "GENE", "pos": [111, 125]}], "task": "NER"}
{"text": "The STP1 locus is located on chromosome IV close to at least two other genes involved in RNA splicing : PRP3 and SPP41 .", "entity": [{"entity": "STP1 locus", "entity_type": "GENE", "pos": [4, 14]}, {"entity": "PRP3", "entity_type": "GENE", "pos": [104, 108]}, {"entity": "SPP41", "entity_type": "GENE", "pos": [113, 118]}], "task": "NER"}
{"text": "Both sequence analysis and restriction fragment length polymorphism analysis revealed a high degree of sequence ( 97 % homology ) and structural similarity among members of the ART - CH family , indicating their common origin and recent penetration into chicken DNA .", "entity": [{"entity": "ART", "entity_type": "GENE", "pos": [177, 180]}, {"entity": "CH", "entity_type": "GENE", "pos": [183, 185]}], "task": "NER"}
{"text": "This interesting exon junction resulted in novel deduced amino terminal open reading frames , which are completely in - frame with sequences located further downstream .", "entity": [], "task": "NER"}
{"text": "We investigated the pattern of evolution of bronchial albumin , IgA , and IgG levels in ventilated ICU patients in relation to nosocomial pneumonia .", "entity": [{"entity": "albumin", "entity_type": "GENE", "pos": [54, 61]}, {"entity": "IgA", "entity_type": "GENE", "pos": [64, 67]}, {"entity": "IgG", "entity_type": "GENE", "pos": [74, 77]}], "task": "NER"}
{"text": "The presence of highly correlated frequencies provided strong evidence of a medium - frequency pattern generator which may remain operative beyond the neonatal period .", "entity": [], "task": "NER"}
{"text": "Pancreatic expression of the glucagon gene depends on multiple transcription factors interacting with at least three DNA control elements : G1 , the upstream promoter element , and G2 and G3 , two enhancer - like sequences .", "entity": [{"entity": "glucagon gene", "entity_type": "GENE", "pos": [29, 42]}], "task": "NER"}
{"text": "Before and 6 and 12 months after H . pylori eradication the patients were evaluated for fasting gastrinemia and pepsinogen I , basal and peak acid output , and detailed histological assessment including the ECL cell proliferative patterns .", "entity": [{"entity": "pepsinogen I", "entity_type": "GENE", "pos": [112, 124]}], "task": "NER"}
{"text": "Thus , CARP is a YB - 1 associated factor and represents the first identified cardiac - restricted downstream regulatory gene in the homeobox gene Nkx2 - 5 pathway and may serve as a negative regulator of HF - 1 - dependent pathways for ventricular muscle gene expression .", "entity": [{"entity": "CARP", "entity_type": "GENE", "pos": [7, 11]}, {"entity": "YB - 1 associated factor", "entity_type": "GENE", "pos": [17, 41]}, {"entity": "Nkx2 - 5", "entity_type": "GENE", "pos": [147, 155]}, {"entity": "HF - 1", "entity_type": "GENE", "pos": [205, 211]}], "task": "NER"}
{"text": "Barium mucosal coating was judged to be better in the members to whom magnesium sulphate was administered ( p = 0 . 0007 ) .", "entity": [], "task": "NER"}
{"text": "Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator ( PTPA ) of protein phosphatase 2A .", "entity": [{"entity": "phosphotyrosyl phosphatase activator", "entity_type": "GENE", "pos": [64, 100]}, {"entity": "PTPA", "entity_type": "GENE", "pos": [103, 107]}, {"entity": "protein phosphatase 2A", "entity_type": "GENE", "pos": [113, 135]}], "task": "NER"}
{"text": "This article expands the analysis of a numeric example included in the SAS GLM procedure to cover several crucial statistical aspects relevant to ANCOVA , and to highlight the meaning of the statistical results obtained .", "entity": [], "task": "NER"}
{"text": "The PEP4 gene was isolated from a genomic DNA library by complementation of the pep4 - 3 mutation .", "entity": [{"entity": "PEP4 gene", "entity_type": "GENE", "pos": [4, 13]}, {"entity": "pep4 - 3", "entity_type": "GENE", "pos": [80, 88]}], "task": "NER"}
{"text": "These results suggest that panretinal photocoagulation offers a highly effective means of dealing with early and moderately advanced cases of angle neovascularization .", "entity": [], "task": "NER"}
{"text": "Bilateral renal oncocytoma in a Greyhound dog .", "entity": [], "task": "NER"}
{"text": "Membrane depolarization is a critical element of neuronal signaling .", "entity": [], "task": "NER"}
{"text": "The E . multilocularis / Mongolian gerbil system can replace the natural canid hosts as a new way to obtain infective eggs and to analyze host - parasite interactions .", "entity": [], "task": "NER"}
{"text": "The Fugu rubripes ( Fugu ) gene fragment was used to isolate the GH gene from a Fugu genomic library .", "entity": [{"entity": "GH gene", "entity_type": "GENE", "pos": [65, 72]}], "task": "NER"}
{"text": "For the first time also a genomic sequence for a red algal lhc gene is presented .", "entity": [{"entity": "red algal lhc gene", "entity_type": "GENE", "pos": [49, 67]}], "task": "NER"}
{"text": "All such polypeptides containing 263 or more residues derived from the C - terminus of P130gag - fps ( i . e . residues 920 - 1182 ) were enzymatically active as tyrosine kinases .", "entity": [{"entity": "P130gag", "entity_type": "GENE", "pos": [87, 94]}, {"entity": "fps", "entity_type": "GENE", "pos": [97, 100]}, {"entity": "tyrosine kinases", "entity_type": "GENE", "pos": [162, 178]}], "task": "NER"}
{"text": "Were this hypothesis correct , the requirement for elF4A should correlate with the degree of mRNA secondary structure .", "entity": [{"entity": "elF4A", "entity_type": "GENE", "pos": [51, 56]}], "task": "NER"}
{"text": "Comparison with the data of clinical development and hemodynamic results", "entity": [], "task": "NER"}
{"text": "Localized Bicaudal - C RNA encodes a protein containing a KH domain , the RNA binding motif of FMR1 .", "entity": [{"entity": "Bicaudal - C RNA", "entity_type": "GENE", "pos": [10, 26]}, {"entity": "FMR1", "entity_type": "GENE", "pos": [95, 99]}], "task": "NER"}
{"text": "Despite a lowering of her plasma ACTH concentration during therapy with valproic acid , the patient ' s tumour showed no evidence of regression while she was taking the drug .", "entity": [{"entity": "ACTH", "entity_type": "GENE", "pos": [33, 37]}], "task": "NER"}
{"text": "This is the first report which clearly proved CEA synthesis in the cells of HCC .", "entity": [{"entity": "CEA", "entity_type": "GENE", "pos": [46, 49]}], "task": "NER"}
{"text": "NASA CR - 1223 .", "entity": [], "task": "NER"}
{"text": "The classic sterol regulatory cis element ( sre - 1 ) in the LDL receptor promoter mediates sterol regulatory element binding protein ( SREBP ) - binding and the effects of insulin and platelet derived growth factor ( PDGF ) .", "entity": [{"entity": "LDL receptor", "entity_type": "GENE", "pos": [61, 73]}, {"entity": "sterol regulatory element binding protein", "entity_type": "GENE", "pos": [92, 133]}, {"entity": "SREBP", "entity_type": "GENE", "pos": [136, 141]}, {"entity": "insulin", "entity_type": "GENE", "pos": [173, 180]}, {"entity": "platelet derived growth factor", "entity_type": "GENE", "pos": [185, 215]}, {"entity": "PDGF", "entity_type": "GENE", "pos": [218, 222]}], "task": "NER"}
{"text": "The D443N substitution is an activating mutation that increases the activity of SCAP and renders it resistant to inhibition by 25 - hydroxycholesterol .", "entity": [{"entity": "D443N substitution", "entity_type": "GENE", "pos": [4, 22]}, {"entity": "SCAP", "entity_type": "GENE", "pos": [80, 84]}], "task": "NER"}
{"text": "Transcriptional modulation of the anti - apoptotic protein BCL - XL by the paired box transcription factors PAX3 and PAX3 / FKHR .", "entity": [{"entity": "anti - apoptotic protein BCL - XL", "entity_type": "GENE", "pos": [34, 67]}, {"entity": "paired box transcription factors", "entity_type": "GENE", "pos": [75, 107]}, {"entity": "PAX3", "entity_type": "GENE", "pos": [108, 112]}, {"entity": "PAX3", "entity_type": "GENE", "pos": [117, 121]}, {"entity": "FKHR", "entity_type": "GENE", "pos": [124, 128]}], "task": "NER"}
{"text": "5 . 3 + / - 6 . 6 for risperidone ( P = 0 . 09 ) .", "entity": [], "task": "NER"}
{"text": "CONCLUSIONS : This study shows that the annual rate of de novo aneurysm formation is relatively high ( 0 . 89 % ) and that the cumulative risk becomes significant after 9 years .", "entity": [], "task": "NER"}
{"text": "In this case myogenic factors are not initially expressed and these migratory cells are characterized by the expression of the paired - box gene Pax3 .", "entity": [{"entity": "paired", "entity_type": "GENE", "pos": [127, 133]}, {"entity": "Pax3", "entity_type": "GENE", "pos": [145, 149]}], "task": "NER"}
{"text": "In those patients who before transplantation were serological negative for CMV but had received organs from CMV - IgG positive donors , the incidence of the disease was highest .", "entity": [{"entity": "CMV - IgG", "entity_type": "GENE", "pos": [108, 117]}], "task": "NER"}
{"text": "The fecal excretion is found to be only one third of that measured in urine .", "entity": [], "task": "NER"}
{"text": "This ERD is recorded over the contralateral central region .", "entity": [], "task": "NER"}
{"text": "We report the sequence of a 7941 bp DNA fragment from the left arm of chromosome VII of Saccharomyces cerevisiae which contains four open reading frames ( ORFs ) of greater than 100 amino acid residues .", "entity": [], "task": "NER"}
{"text": "Tax was demonstrated to interact directly with CREB1 but not with other bZIP proteins , including CREB2 and Jun .", "entity": [{"entity": "Tax", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "CREB1", "entity_type": "GENE", "pos": [47, 52]}, {"entity": "bZIP proteins", "entity_type": "GENE", "pos": [72, 85]}, {"entity": "CREB2", "entity_type": "GENE", "pos": [98, 103]}, {"entity": "Jun", "entity_type": "GENE", "pos": [108, 111]}], "task": "NER"}
{"text": "Forty - five per cent of the dose was excreted as methyldopa as opposed to 18 % normally seen after oral methyldopa dosages .", "entity": [], "task": "NER"}
{"text": "Standing values : placebo 114 / 79 ; BHT - 933 92 / 67 .", "entity": [], "task": "NER"}
{"text": "Zoonotic areas in which HIV co - infection is common could also be at risk as sandflies can become infected from co - infected individuals .", "entity": [], "task": "NER"}
{"text": "In cases in which it was identified , insulitis affected 23 % of islets containing insulin , but affected only 1 % of islets which were insulin deficient , thus supporting the concept that insulitis represents an immunologically mediated destruction of insulin secreting B cells .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [83, 90]}, {"entity": "insulin", "entity_type": "GENE", "pos": [136, 143]}, {"entity": "insulin", "entity_type": "GENE", "pos": [253, 260]}], "task": "NER"}
{"text": "Each fusion leads , in principle , to the same effect : The ret tyrosine kinase is uncoupled from its stringent physiological regulation by replacement of its 5 ' end and is aberrantly activated by the 5 ' parts of fused genes in thyrocytes that do not normally express ret tyrosine kinase .", "entity": [{"entity": "ret tyrosine kinase", "entity_type": "GENE", "pos": [60, 79]}, {"entity": "ret tyrosine kinase", "entity_type": "GENE", "pos": [270, 289]}], "task": "NER"}
{"text": "Proteins PBP - 1 and PBP - 2 bind to two of the three promoter elements in the trypanosomatid Leptomonas seymouri .", "entity": [{"entity": "PBP - 1", "entity_type": "GENE", "pos": [9, 16]}, {"entity": "PBP - 2", "entity_type": "GENE", "pos": [21, 28]}], "task": "NER"}
{"text": "Induction of interferon - alpha ( IFNalpha ) gene expression in virus - infected cells requires phosphorylation - induced activation of the transcription factors IRF3 and IRF7 .", "entity": [{"entity": "interferon - alpha", "entity_type": "GENE", "pos": [13, 31]}, {"entity": "IFNalpha", "entity_type": "GENE", "pos": [34, 42]}, {"entity": "IRF3", "entity_type": "GENE", "pos": [162, 166]}, {"entity": "IRF7", "entity_type": "GENE", "pos": [171, 175]}], "task": "NER"}
{"text": "The differences of percentages for HIV - 1 infection in intravenous drug users ( IVDU ) were 67 . 7 % and in non IVDU were 3 . 8 % with a significant statistical difference ( chi 2 = 557 . 5 ; p < 0 . 0001 ) .", "entity": [], "task": "NER"}
{"text": "Humoral immunity is altered with the drop in IgG levels .", "entity": [{"entity": "IgG", "entity_type": "GENE", "pos": [45, 48]}], "task": "NER"}
{"text": "The vicinity of large industrial emissions of lead , where mean Pb - B concentrations were usually twice as high as in rural areas of the Katowice voivodship .", "entity": [], "task": "NER"}
{"text": "( control hearts ) .", "entity": [], "task": "NER"}
{"text": "Thus , BCR ligation initiates a PI 3 - kinase / Akt / GSK - 3 signaling pathway .", "entity": [{"entity": "BCR", "entity_type": "GENE", "pos": [7, 10]}, {"entity": "PI 3 - kinase", "entity_type": "GENE", "pos": [32, 45]}, {"entity": "Akt", "entity_type": "GENE", "pos": [48, 51]}, {"entity": "GSK - 3", "entity_type": "GENE", "pos": [54, 61]}], "task": "NER"}
{"text": "Effect of a new positive inotropic agent ( OPC - 8212 ) on intracellular potential of isolated canine ventricular papillary muscle", "entity": [], "task": "NER"}
{"text": "Although several other signal transduction molecules also contain tandemly occurring SH3 and SH2 domains , the function of these closely spaced domains is not well understood .", "entity": [{"entity": "SH3", "entity_type": "GENE", "pos": [85, 88]}, {"entity": "SH2 domains", "entity_type": "GENE", "pos": [93, 104]}], "task": "NER"}
{"text": "At the same acoustic power , the rate of chloride formation with 20 kHz ultrasound was greater when a probe with a larger tip area was used , but significantly less than the rate with 900 kHz .", "entity": [], "task": "NER"}
{"text": "This is the first report demonstrating specificity at the level of the energy coupling proteins of the PTS .", "entity": [], "task": "NER"}
{"text": "The R260A mutant , as expected , was unable to support mRNA synthesis in vitro in a transcription reconstitution reaction as well as transcription in vivo of a minigenome using a reverse genetic approach .", "entity": [], "task": "NER"}
{"text": "As expected , the QOLS - N had a lower correlation with physical health ( r = 0 . 24 , p < 0 . 000 ) and self - reported symptoms ( r = - 0 . 20 , p < 0 . 001 ) , and a higher correlation with mental health ( r = 0 . 52 , p < 0 . 000 ) .", "entity": [], "task": "NER"}
{"text": "Human epidermal growth factor ( EGF ) , a naturally occurring protein , has been implicated in the protection of gastrointestinal mucosal integrity .", "entity": [{"entity": "Human epidermal growth factor", "entity_type": "GENE", "pos": [0, 29]}, {"entity": "EGF", "entity_type": "GENE", "pos": [32, 35]}], "task": "NER"}
{"text": "Elevated potassium stimulation of GAL mRNA was completely blocked , but pituitary adenylyl cyclase - activating polypeptide and histamine stimulations were only partially blocked , by cycloheximide .", "entity": [{"entity": "GAL mRNA", "entity_type": "GENE", "pos": [34, 42]}, {"entity": "adenylyl cyclase - activating polypeptide", "entity_type": "GENE", "pos": [82, 123]}], "task": "NER"}
{"text": "DNA elements recognizing NF - Y and Sp1 regulate the human multidrug - resistance gene promoter .", "entity": [{"entity": "NF - Y", "entity_type": "GENE", "pos": [25, 31]}, {"entity": "Sp1", "entity_type": "GENE", "pos": [36, 39]}, {"entity": "human multidrug - resistance gene promoter", "entity_type": "GENE", "pos": [53, 95]}], "task": "NER"}
{"text": "We constructed a series of chimeric genes containing part of the first exon and increasingly longer 5 ' flanking sequences of the ODC gene fused to either bacterial chloramphenicol acetyltransferase ( CAT ) or luciferase reporter genes .", "entity": [{"entity": "ODC gene", "entity_type": "GENE", "pos": [130, 138]}, {"entity": "bacterial chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [155, 198]}, {"entity": "CAT", "entity_type": "GENE", "pos": [201, 204]}, {"entity": "luciferase reporter genes", "entity_type": "GENE", "pos": [210, 235]}], "task": "NER"}
{"text": "To investigate this possibility , we conducted split - visual - field studies in which we manipulated stimulus sets , recognition task , and exposure duration .", "entity": [], "task": "NER"}
{"text": "Like pimethixene and cyproheptadine , WA 335 has no distinct antagonistic qualities against bradykinin .", "entity": [{"entity": "bradykinin", "entity_type": "GENE", "pos": [92, 102]}], "task": "NER"}
{"text": "To explore the mechanism of insulin receptor phosphorylation we have used NIH3T3 cells transfected with two receptor constructs : one encoding a chimeric receptor composed of the extracellular domain of the human EGF receptor and the cytosolic domain of the human insulin receptor beta - subunit , and a second construct encoding a kinase - defiecient human insulin receptor .", "entity": [{"entity": "insulin receptor", "entity_type": "GENE", "pos": [28, 44]}, {"entity": "human EGF receptor", "entity_type": "GENE", "pos": [207, 225]}, {"entity": "human insulin receptor beta - subunit", "entity_type": "GENE", "pos": [258, 295]}, {"entity": "human insulin receptor", "entity_type": "GENE", "pos": [352, 374]}], "task": "NER"}
{"text": "Additional simulations account for interactions of spatial frequency with stimulus duration , effects of adaptation , and properties of residual traces , as opposed to visual persistence .", "entity": [], "task": "NER"}
{"text": "A DNA fragment that complements the uvs - 2 mutation was subcloned by monitoring its ability to transform the uvs - 2 mutant to MMS resistance .", "entity": [{"entity": "uvs - 2", "entity_type": "GENE", "pos": [36, 43]}, {"entity": "uvs - 2 mutant", "entity_type": "GENE", "pos": [110, 124]}], "task": "NER"}
{"text": "This cell line expresses productively rearranged immunoglobulin genes as well as the Oct - 2 gene at high levels which are comparable to those observed in activated murine splenic B cells .", "entity": [{"entity": "immunoglobulin genes", "entity_type": "GENE", "pos": [49, 69]}, {"entity": "Oct - 2 gene", "entity_type": "GENE", "pos": [85, 97]}], "task": "NER"}
{"text": "Back - ground factors which affect the outcome of steroid withdrawal therapy in patients with chronic type B hepatitis - - statistical evaluation of the importance of the mode of HBV transmission", "entity": [], "task": "NER"}
{"text": "Effect of food on hemodynamics .", "entity": [], "task": "NER"}
{"text": "PTP1 - lacZ studies indicate that PTP1 is spatially localized to prestalk and anterior - like cell types .", "entity": [{"entity": "PTP1", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "lacZ", "entity_type": "GENE", "pos": [7, 11]}, {"entity": "PTP1", "entity_type": "GENE", "pos": [34, 38]}], "task": "NER"}
{"text": "Morphologic evidence that rhe renal calyx and pelvis control ureteric activity in the rabbit .", "entity": [], "task": "NER"}
{"text": "Human alcohol dehydrogenase ( ADH ) exists as a heterogeneous group of isozymes capable of oxidizing a wide variety of aliphatic and aromatic alcohols .", "entity": [{"entity": "Human alcohol dehydrogenase", "entity_type": "GENE", "pos": [0, 27]}, {"entity": "ADH", "entity_type": "GENE", "pos": [30, 33]}], "task": "NER"}
{"text": "We reviewed 81 patients with dementia and autopsy findings of Alzheimer ' s disease ( AD ) to identify patients with seizures or myoclonus after onset of dementia .", "entity": [], "task": "NER"}
{"text": "The second system ( VacFix ) uses a 0 . 15 mm thick plastic bag loosely filled with 1 mm polysterol spheres .", "entity": [], "task": "NER"}
{"text": "Expression in all lines was decreased by the inclusion of regions further upstream , and extinguished by the inclusion of the first intron .", "entity": [], "task": "NER"}
{"text": "These results indicate that the changes in the patient ' s thyroid scan and RAIU were attributable to the presence of TSAb .", "entity": [], "task": "NER"}
{"text": "U .", "entity": [], "task": "NER"}
{"text": "A Laboratory Manual , 2nd ed .", "entity": [], "task": "NER"}
{"text": "In the case of a moderate buccal Class II tendency , 55 % of the molars were in a Class I relationship when evaluated from the lingual side , whereas 45 % belonged to mild ( 1st degrees ) Class II with molar rotations present in 81 % of the cases .", "entity": [], "task": "NER"}
{"text": "The resulting score , which allowed the disease to be expressed as a continuous variable , was effectively utilized to see the correlations between the severity of coronary arterial disease ( CAD ) and individual risk factors / risk markers .", "entity": [], "task": "NER"}
{"text": "The gene encoding the cellulase ( Avicelase ) Cel1 from Streptomyces reticuli and analysis of protein domains .", "entity": [{"entity": "cellulase", "entity_type": "GENE", "pos": [22, 31]}, {"entity": "Avicelase", "entity_type": "GENE", "pos": [34, 43]}, {"entity": "Cel1", "entity_type": "GENE", "pos": [46, 50]}], "task": "NER"}
{"text": "A protein which promotes DNA strand transfer between linear double - stranded M13mp19 DNA and single - stranded viral M13mp19 DNA has been isolated from recA - E . coli .", "entity": [{"entity": "recA -", "entity_type": "GENE", "pos": [153, 159]}], "task": "NER"}
{"text": "We speculate that the enhancing effect of glucose and galactose on fructose absorption may be due to activation of the fructose carrier .", "entity": [{"entity": "fructose carrier", "entity_type": "GENE", "pos": [119, 135]}], "task": "NER"}
{"text": "The nutraceuticals of specific vitamins , minerals , phytoestrogens , and essential fatty acid supplementations are a vital component of the risk reduction health program .", "entity": [], "task": "NER"}
{"text": "Thus , in V . furnissii , the E . coli manX equivalent comprises two genes , which are separated in the genome by two other genes of the ptsM complex .", "entity": [{"entity": "E . coli manX equivalent", "entity_type": "GENE", "pos": [30, 54]}, {"entity": "ptsM complex", "entity_type": "GENE", "pos": [137, 149]}], "task": "NER"}
{"text": "An scrR promoter fragment , which dose not contain a sequence resembling OB , was not shifted by the fusion protein .", "entity": [{"entity": "scrR promoter fragment", "entity_type": "GENE", "pos": [3, 25]}, {"entity": "OB", "entity_type": "GENE", "pos": [73, 75]}], "task": "NER"}
{"text": "Ectopic expression of cyclin D1 in progestin - inhibited cells led to the reappearance of the 120 - kDa active form of cyclin E - Cdk2 preceding the resumption of cell cycle progression .", "entity": [{"entity": "cyclin D1", "entity_type": "GENE", "pos": [22, 31]}, {"entity": "cyclin E", "entity_type": "GENE", "pos": [119, 127]}, {"entity": "Cdk2", "entity_type": "GENE", "pos": [130, 134]}], "task": "NER"}
{"text": "We screened an A . thaliana cDNA library , whose inserts are under the control of the galactose - inducible GAL10 promoter , for cDNAs which enabled YDH8 cells to grow at the restrictive temperature .", "entity": [{"entity": "GAL10 promoter", "entity_type": "GENE", "pos": [108, 122]}], "task": "NER"}
{"text": "The mouse alpha A - CRYBP1 gene specifies a 2 , 688 - amino acid protein with 72 % amino acid identity to its human homologue , PRDII - BF1 .", "entity": [{"entity": "mouse alpha A - CRYBP1 gene", "entity_type": "GENE", "pos": [4, 31]}, {"entity": "PRDII - BF1", "entity_type": "GENE", "pos": [128, 139]}], "task": "NER"}
{"text": "Sequence analysis revealed that Hv - p68 belongs to the large family of FAD - dependent glucose methanol choline oxidoreductases and that it shares significant sequence identity ( > 67 % ) with the alcohol oxidases of the methylotrophic yeasts .", "entity": [{"entity": "Hv - p68", "entity_type": "GENE", "pos": [32, 40]}, {"entity": "FAD - dependent glucose methanol choline oxidoreductases", "entity_type": "GENE", "pos": [72, 128]}, {"entity": "alcohol oxidases", "entity_type": "GENE", "pos": [198, 214]}], "task": "NER"}
{"text": "Therefore , we have reevaluated the age - related changes in serum leptin levels and their relationship with adiposity and androgen levels in a large group of community dwelling men .", "entity": [{"entity": "serum leptin", "entity_type": "GENE", "pos": [61, 73]}], "task": "NER"}
{"text": "The 1 - year and 2 - year survival rates for the patients with N0 - 3 significantly exceeded those of N4 patients .", "entity": [], "task": "NER"}
{"text": "While reviewing gastric specimens from 215 baboons , we found diffuse giant mucosal folds in 2 specimens and multiple giant mucosal nodules in another 3 .", "entity": [], "task": "NER"}
{"text": "Morphologically , corrugation of the internal elastic lamina of vessels was often observed in the vehicle - treated group , but was not prominent in the GLNVA - treated groups or healthy controls .", "entity": [], "task": "NER"}
{"text": "Transcripts initiating at the CAGT motif ( proximal transcripts ) were abolished by deletion of the proximal TATA box located at - 29 relative to CAGT .", "entity": [], "task": "NER"}
{"text": "The phenomena of nursing are deeply rooted in the human condition .", "entity": [], "task": "NER"}
{"text": "Coronatine ( COR ) is a plasmid - encoded phytotoxin synthesized by several pathovars of phytopathogenic Pseudomonas syringae .", "entity": [{"entity": "Coronatine", "entity_type": "GENE", "pos": [0, 10]}, {"entity": "COR", "entity_type": "GENE", "pos": [13, 16]}], "task": "NER"}
{"text": "It has become clear that there is not one mediator responsible for ALI , but rather a complex interplay exists between diverse proinflammatory ( e . g . , lipopolysaccharide , complement products , cytocains , chemocains , reactive oxygen species and arachidonic acid products ) and anti - inflammatory ( IL - 10 , IL - 1 - RA , PGI2 ) mediators .", "entity": [{"entity": "IL - 10", "entity_type": "GENE", "pos": [305, 312]}, {"entity": "IL - 1 - RA", "entity_type": "GENE", "pos": [315, 326]}], "task": "NER"}
{"text": "Not only will it substantially reduce incident cases of hepatitis B for the next decade , it will also provide a framework for the successful introduction of future adolescent vaccine initiatives in Australia .", "entity": [], "task": "NER"}
{"text": "Radioactively labeled microspheres were used to determine and compare the hemodynamic effects of sodium nitroprusside ( SNP ) , nitroglycerin ( NTG ) , and deep enflurane anesthesia on oral tissues during controlled hypotension when compared with controls .", "entity": [], "task": "NER"}
{"text": "We conclude that the MMF lesion is secondary to intramuscular injection of aluminium hydroxide - containing vaccines , shows both long - term persistence of aluminium hydroxide and an ongoing local immune reaction , and is detected in patients with systemic symptoms which appeared subsequently to vaccination .", "entity": [], "task": "NER"}
{"text": "Advisory Committee report recommends that US make amends for human radiation experiments .", "entity": [], "task": "NER"}
{"text": "An evaluation of a positive control for platelet neutralization procedure testing with seven commercial activated partial thromboplastin time reagents .", "entity": [{"entity": "thromboplastin", "entity_type": "GENE", "pos": [122, 136]}], "task": "NER"}
{"text": "Transmission of mutans streptococci to infants following short term application of an iodine - NaF solution to mothers ' dentition .", "entity": [], "task": "NER"}
{"text": "Glycoprotein biosynthesis in Saccharomyces cerevisiae : ngd29 , an N - glycosylation mutant allelic to och1 having a defect in the initiation of outer chain formation .", "entity": [{"entity": "ngd29", "entity_type": "GENE", "pos": [56, 61]}, {"entity": "och1", "entity_type": "GENE", "pos": [103, 107]}], "task": "NER"}
{"text": "However , no consensus on indications exists and , according to the literature , results are contradictory .", "entity": [], "task": "NER"}
{"text": "The effects of erythrosine ( Red 3 ) , rose bengal B ( Red 105 ) and thyroidectomy on the development of thyroid tumor were examined in male Wistar rats treated with N - bis ( 2 - hydroxypropyl ) nitrosamine ( DHPN ) .", "entity": [], "task": "NER"}
{"text": "The region surrounding the ZNF35 zinc finger protein gene on 3p21 is of particular interest , as this region of chromosome 3 is frequently involved in rearrangements and / or deletions associated with various human tumors including lung and renal carcinoma .", "entity": [{"entity": "ZNF35 zinc finger protein gene", "entity_type": "GENE", "pos": [27, 57]}], "task": "NER"}
{"text": "In contrast , no change in the level of either p53 or activation of mdm2 protein by p53 was observed in hamster UV61 cells after UV exposure .", "entity": [{"entity": "p53", "entity_type": "GENE", "pos": [47, 50]}, {"entity": "mdm2 protein", "entity_type": "GENE", "pos": [68, 80]}, {"entity": "p53", "entity_type": "GENE", "pos": [84, 87]}], "task": "NER"}
{"text": "Complete activation of signal transducer and activator of transcription 1 ( STAT1 ) requires phosphorylation at both Y701 and a conserved PMS ( 727 ) P sequence .", "entity": [{"entity": "signal transducer and activator of transcription 1", "entity_type": "GENE", "pos": [23, 73]}, {"entity": "STAT1", "entity_type": "GENE", "pos": [76, 81]}], "task": "NER"}
{"text": "It is believed that the operation is effective because it cuts the spinothalamic tract ( STT ) , a primary pathway carrying nociceptive information from the spinal cord to the brain in humans .", "entity": [], "task": "NER"}
{"text": "On the basis of experiments with mutant virus and transfection with isolated genes , the herpes simplex virus immediate - early gene product ICP4 is known to positively regulate the transcription of viral early and late genes and negatively regulate expression from its own promoter .", "entity": [{"entity": "herpes simplex virus immediate - early gene", "entity_type": "GENE", "pos": [89, 132]}, {"entity": "ICP4", "entity_type": "GENE", "pos": [141, 145]}, {"entity": "viral early and late genes", "entity_type": "GENE", "pos": [199, 225]}], "task": "NER"}
{"text": "Alcohol abuse and treatment resistance in skin disease .", "entity": [], "task": "NER"}
{"text": "These data suggest that reduction in PRA may have contributed to the hemodynamic effects of this peak III PDE inhibitor .", "entity": [{"entity": "peak III PDE", "entity_type": "GENE", "pos": [97, 109]}], "task": "NER"}
{"text": "However , studies using the A20 promoter demonstrated that LMP1 transcriptionally activates the A20 gene through cis - acting kappa B sites .", "entity": [{"entity": "A20 promoter", "entity_type": "GENE", "pos": [28, 40]}, {"entity": "LMP1", "entity_type": "GENE", "pos": [59, 63]}, {"entity": "A20 gene", "entity_type": "GENE", "pos": [96, 104]}, {"entity": "kappa B sites", "entity_type": "GENE", "pos": [126, 139]}], "task": "NER"}
{"text": "The first 270 bp of the promoter region were sequenced and found to contain a CATAA box rather than a TATAA box and several DNA motifs found in activation genes .", "entity": [], "task": "NER"}
{"text": "This study investigated if signal - averaged low amplitude atrial potentials predict atrial fibrillation or flutter ( AFF ) .", "entity": [], "task": "NER"}
{"text": "The reduced expression caused by multimerization of UAS2 in the native promoter was observed only in the presence of ADR1 .", "entity": [{"entity": "ADR1", "entity_type": "GENE", "pos": [117, 121]}], "task": "NER"}
{"text": "Finally , we tested whether activation by either of these factors is dependent on components of the SAGA complex .", "entity": [{"entity": "SAGA complex", "entity_type": "GENE", "pos": [100, 112]}], "task": "NER"}
{"text": "One child , recently fed , vomited a small amount of breast milk after a short period of crying and apparently had a laryngospasm , shown by a sudden drop in the PtcO2 level without any other signs of discomfort .", "entity": [], "task": "NER"}
{"text": "The central venous O2 saturation test in acute pulmonary fat embolism .", "entity": [], "task": "NER"}
{"text": "Such unique recognition capabilities are generated with minimal alterations in the CDR3 loops of the TCR .", "entity": [{"entity": "CDR3", "entity_type": "GENE", "pos": [83, 87]}, {"entity": "TCR", "entity_type": "GENE", "pos": [101, 104]}], "task": "NER"}
{"text": "Sequence comparisons reveal that the P . woesei GTP - binding protein is strikingly related in sequence to eubacterial FtsZ and is marginally more similar to eukaryotic tubulins than are bacterial FtsZ proteins .", "entity": [{"entity": "P . woesei GTP - binding protein", "entity_type": "GENE", "pos": [37, 69]}, {"entity": "eubacterial FtsZ", "entity_type": "GENE", "pos": [107, 123]}, {"entity": "eukaryotic tubulins", "entity_type": "GENE", "pos": [158, 177]}, {"entity": "bacterial FtsZ proteins", "entity_type": "GENE", "pos": [187, 210]}], "task": "NER"}
{"text": "Additional transection of both ADN eliminated the remaining sigmoidal correlation between MAP and RSNA with further increases in resting MAP and RSNA .", "entity": [], "task": "NER"}
{"text": "Cross - talk between transcription factors NF - kappa B and C / EBP in the transcriptional regulation of genes .", "entity": [{"entity": "NF - kappa B", "entity_type": "GENE", "pos": [43, 55]}, {"entity": "C / EBP", "entity_type": "GENE", "pos": [60, 67]}], "task": "NER"}
{"text": "FDP - 1 ( 200 micrograms . kg - 1 ) of intracoronary injection increased collateral flow , reduced systemic artery resistance , and coronary systolic pressure in infarcted region and the area of infarction decreased from 28 . 9 + / - 1 . 3 % to 15 . 3 + / - 1 . 2 % ( P < 0 . 01 , n = 6 ) .", "entity": [], "task": "NER"}
{"text": "The results of these experiments indicated that charcoal , imbiber beads , and the anion exchanges resins , Dowex XFS - 4022 and Dowex SBR - C1 , would not be useful agents for increasing the amount of dieldrin eliminated via feces ( droppings ) of chickens .", "entity": [], "task": "NER"}
{"text": "Neither raw nor retrograded resistant starch lowers fasting serum cholesterol concentrations in healthy normolipidemic subjects .", "entity": [], "task": "NER"}
{"text": "A regression analysis showed that 86 % of the variance in weight gain was predicted by two leading indicators in the middle phase of treatment .", "entity": [], "task": "NER"}
{"text": "Heterologous hybridization with a rps12 gene specific probe from Euglena has revealed the presence of rps12 homologous sequences within the inverted repeat of Spirodela chloroplast DNA on the fragment BamHI - V .", "entity": [{"entity": "rps12 gene", "entity_type": "GENE", "pos": [34, 44]}, {"entity": "rps12 homologous sequences", "entity_type": "GENE", "pos": [102, 128]}, {"entity": "fragment BamHI - V", "entity_type": "GENE", "pos": [192, 210]}], "task": "NER"}
{"text": "In 6 patients ( 9 kidneys ) irrigation with Solution G in the renal pelvis was performed for the dissolution of their infectious stones .", "entity": [], "task": "NER"}
{"text": "Derepression of RAR signaling by expressing a dominant - negative corepressor resulted in embryos that exhibited phenotypes similar to those treated by RA .", "entity": [{"entity": "RAR", "entity_type": "GENE", "pos": [16, 19]}], "task": "NER"}
{"text": "Flux of the paramyxovirus hemagglutinin - neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78 - BiP gene .", "entity": [{"entity": "hemagglutinin", "entity_type": "GENE", "pos": [26, 39]}, {"entity": "neuraminidase", "entity_type": "GENE", "pos": [42, 55]}, {"entity": "GRP78", "entity_type": "GENE", "pos": [134, 139]}, {"entity": "BiP", "entity_type": "GENE", "pos": [142, 145]}], "task": "NER"}
{"text": "Within the final 11 amino acids there are 5 aromatic , 2 basic , and no acidic residues and it has been proposed that these residues stack with and electrostatically interact with the kinked DNA at the site of a pyrimidine dimer .", "entity": [], "task": "NER"}
{"text": "The influence of different temperatures between 13 degrees C and 45 degrees C on coagulation factors in vitro was studied by measuring clotting time with the recalcification time , partial thromboplastin time ( PTT ) , and thromboplastin time test .", "entity": [{"entity": "thromboplastin", "entity_type": "GENE", "pos": [189, 203]}, {"entity": "thromboplastin", "entity_type": "GENE", "pos": [223, 237]}], "task": "NER"}
{"text": "Recombinant propeptides containing mutations of one of the three tryptophan residues were three orders of magnitude less effective as inhibitors of mature cathepsin S than the wild - type propeptide .", "entity": [{"entity": "mature cathepsin S", "entity_type": "GENE", "pos": [148, 166]}], "task": "NER"}
{"text": "Molecular cloning of cDNAs encoding alpha - subunits of guanine nucleotide - binding regulatory proteins ( G - proteins ) has revealed the existence of nine species of alpha - subunits .", "entity": [{"entity": "guanine nucleotide - binding regulatory proteins", "entity_type": "GENE", "pos": [56, 104]}, {"entity": "G - proteins", "entity_type": "GENE", "pos": [107, 119]}], "task": "NER"}
{"text": "In all cases , a large fraction of soluble Al became insoluble in the stomach after ingestion .", "entity": [], "task": "NER"}
{"text": "The free fraction of amitriptyline ( AT ) , measured by equilibrium dialysis in plasma from 29 AT - treated depressed patients , was 5 . 4 - 9 . 8 % ( mean 7 . 7 % ) , which was the same as the values in 26 healthy controls ( 4 . 9 - 9 . 6 % , mean 7 . 6 % ) .", "entity": [], "task": "NER"}
{"text": "The prominent fracture of women older than 75 years is the hip fracture ( type II osteoporosis ) .", "entity": [], "task": "NER"}
{"text": "AU - rich elements in the 3 ' - untranslated region of a new mucin - type gene family of Trypanosoma cruzi confers mRNA instability and modulates translation efficiency .", "entity": [{"entity": "mucin - type gene", "entity_type": "GENE", "pos": [61, 78]}], "task": "NER"}
{"text": "Under anaerobic conditions ( a 50 - day experiment ) these organisms degraded 15 - 18 % of the TEM , 20 - 25 % of some alkanes , and 15 - 18 % of selected polycyclic aromatic hydrocarbons .", "entity": [], "task": "NER"}
{"text": "They cause temporary disability , invalidity and mortality of a great part of the productive population , significantly damaging the economic status of the country .", "entity": [], "task": "NER"}
{"text": "We then isolated the full - length coding region of the human BACH1 gene using expressed sequence tags , reverse transcription - polymerase chain reaction and rapid amplification of cDNA ends .", "entity": [{"entity": "human BACH1 gene", "entity_type": "GENE", "pos": [56, 72]}], "task": "NER"}
{"text": "In addition , wild - type and mutated DNA templates were used as probes in DNase I protection experiments to determine sites of protein - DNA interaction .", "entity": [{"entity": "DNase I", "entity_type": "GENE", "pos": [75, 82]}], "task": "NER"}
{"text": "CONCLUSIONS - - Postlumbar puncture headache may be mediated by the release of substance P triggered by lumbar puncture , in patients predisposed to headache by a hypersensitivity to substance P .", "entity": [{"entity": "substance P", "entity_type": "GENE", "pos": [79, 90]}, {"entity": "substance P", "entity_type": "GENE", "pos": [183, 194]}], "task": "NER"}
{"text": "The repeats are highly conserved both within a given element as well as between different members of the family ( less than 10 % divergence ) .", "entity": [], "task": "NER"}
{"text": "They are found to have several advantages over the conventional indices of skewness and kurtosis ( square root of b1 and b2 ) and no serious drawbacks .", "entity": [], "task": "NER"}
{"text": "Second , CGGA - containing sequences placed at - 88 in the delta MTV - CAT reporter plasmid conferred insulin responsiveness to the mammary tumor virus promoter .", "entity": [{"entity": "delta MTV - CAT reporter", "entity_type": "GENE", "pos": [59, 83]}, {"entity": "insulin", "entity_type": "GENE", "pos": [102, 109]}, {"entity": "mammary tumor virus promoter", "entity_type": "GENE", "pos": [132, 160]}], "task": "NER"}
{"text": "Hemorrheological evaluation and proposed pharmacological uses .", "entity": [], "task": "NER"}
{"text": "Stimulation of the endosteal bone formation rate was mainly impaired in D - depleted rats , resulting in trabecular bone loss , which , in - D mother rats , was associated with decreased bone ash and total bone calcium .", "entity": [], "task": "NER"}
{"text": "Biochemical status was examined using erythrocyte enzyme function and blood vitamin levels .", "entity": [], "task": "NER"}
{"text": "The Polycomb group proteins are involved in maintenance of the silenced state of several developmentally regulated genes .", "entity": [{"entity": "Polycomb group proteins", "entity_type": "GENE", "pos": [4, 27]}], "task": "NER"}
{"text": "Repeated interferon - beta ( IFN - beta ) silencer B motifs and a lysozyme silencer 1 motif have been found in the CD95 gene at approximately - 1 , 600 and - 1 , 100 , respectively .", "entity": [{"entity": "interferon - beta", "entity_type": "GENE", "pos": [9, 26]}, {"entity": "IFN - beta", "entity_type": "GENE", "pos": [29, 39]}, {"entity": "lysozyme silencer 1 motif", "entity_type": "GENE", "pos": [66, 91]}, {"entity": "CD95 gene", "entity_type": "GENE", "pos": [115, 124]}], "task": "NER"}
{"text": "We find that Fus3p and Kss1p both control G1 arrest through multiple functions that operate in parallel with Far1p .", "entity": [{"entity": "Fus3p", "entity_type": "GENE", "pos": [13, 18]}, {"entity": "Kss1p", "entity_type": "GENE", "pos": [23, 28]}, {"entity": "Far1p", "entity_type": "GENE", "pos": [109, 114]}], "task": "NER"}
{"text": "The Id4 protein contains a HLH domain highly conserved among the dnHLH proteins from mouse and drosophila .", "entity": [{"entity": "Id4 protein", "entity_type": "GENE", "pos": [4, 15]}, {"entity": "dnHLH proteins", "entity_type": "GENE", "pos": [65, 79]}], "task": "NER"}
{"text": "The proliferative potential of the pilocytic astrocytoma : the relation between MIB - 1 labeling and clinical and neuro - radiological follow - up .", "entity": [{"entity": "MIB - 1", "entity_type": "GENE", "pos": [80, 87]}], "task": "NER"}
{"text": "Desensitization of the growth hormone - induced Janus kinase 2 ( Jak 2 ) / signal transducer and activator of transcription 5 ( Stat5 ) - signaling pathway requires protein synthesis and phospholipase C .", "entity": [{"entity": "growth hormone", "entity_type": "GENE", "pos": [23, 37]}, {"entity": "Janus kinase 2", "entity_type": "GENE", "pos": [48, 62]}, {"entity": "Jak 2", "entity_type": "GENE", "pos": [65, 70]}, {"entity": "signal transducer and activator of transcription 5", "entity_type": "GENE", "pos": [75, 125]}, {"entity": "Stat5", "entity_type": "GENE", "pos": [128, 133]}, {"entity": "phospholipase C", "entity_type": "GENE", "pos": [187, 202]}], "task": "NER"}
{"text": "The aim of our study was to determine whether exercise training can augment left ventricular diastolic filling at rest and during exercise in patients with ischemic cardiomyopathy and whether any correlation exists between changes in diastolic filling and changes in exercise tolerance .", "entity": [], "task": "NER"}
{"text": "Alterations in TCR - MHC contacts subsequent to cross - recognition of class I MHC and singly substituted peptide variants .", "entity": [{"entity": "TCR", "entity_type": "GENE", "pos": [15, 18]}, {"entity": "MHC", "entity_type": "GENE", "pos": [21, 24]}, {"entity": "class I MHC", "entity_type": "GENE", "pos": [71, 82]}], "task": "NER"}
{"text": "Scalp blood flow was recorded by a laser Doppler flow sensor that was incorporated in the transcutaneous PO2 electrode .", "entity": [], "task": "NER"}
{"text": "There is an overall functional similarity between IL - 6 and c - fos promoters , since transfection of excess amounts of either promoter DNA into intact HeLa cells modulates the function of the heterologous promoter construct .", "entity": [{"entity": "IL - 6", "entity_type": "GENE", "pos": [50, 56]}, {"entity": "c - fos promoters", "entity_type": "GENE", "pos": [61, 78]}], "task": "NER"}
{"text": "Detailed comparison of the sequences of cp35 and human calpactin II shows that the only substantial sequence dissimilarity is a domain encoding amino acids between residues 20 and 40 which includes a tyrosine phosphorylation site in the human molecule , along with other residues of possible physiological significance .", "entity": [{"entity": "cp35", "entity_type": "GENE", "pos": [40, 44]}, {"entity": "human calpactin II", "entity_type": "GENE", "pos": [49, 67]}], "task": "NER"}
{"text": "Power deposition by inverse - bremsstrahlung is modeled with a scheme based on Gaussian quadrature to accommodate a deposition rate whose spatial variation is highly nonuniform .", "entity": [], "task": "NER"}
{"text": "However , the malaria vectors Anopheles funestus and An . gambiae have both become more abundant during the 1970s and 1980s and sporozoite - positive specimens of both have been found .", "entity": [], "task": "NER"}
{"text": "Greer , and L . A .", "entity": [], "task": "NER"}
{"text": "Expression of Msx - 1 and Msx - 2 has been studied during development of the osteoblast phenotype , but the role of Dlx in this context and in the regulation of bone - expressed genes is unknown .", "entity": [{"entity": "Msx - 1", "entity_type": "GENE", "pos": [14, 21]}, {"entity": "Msx - 2", "entity_type": "GENE", "pos": [26, 33]}, {"entity": "Dlx", "entity_type": "GENE", "pos": [116, 119]}], "task": "NER"}
{"text": "The salt sensitivity of the interaction indicated that two ion pairs are involved in the association of Zn2 + ( NC - F1 ) with polynucleotide , whereas one ion pair is found in the metal - free peptide - nucleic acid complex .", "entity": [], "task": "NER"}
{"text": "Histopathologically , ( mice killed with high doses of GMC - II , given orally ) there were diffuse hyperemia of the liver , parenchymal degeneration of the kidney tubuli epithelium , and edema and emphysema of the lungs .", "entity": [], "task": "NER"}
{"text": "Cytochemical and ultrastructural observations on the tegument of the trematode Megalodiscus temperatus .", "entity": [], "task": "NER"}
{"text": "The overall rate of biohydrogenation of C18 : 2 was 14 . 3 % / h , but declined 1 . 2 % / h for each percentage unit increase in C18 : 2 added to the substrate .", "entity": [], "task": "NER"}
{"text": "Transient thyrotoxicosis in primary anti - phospholipid syndrome .", "entity": [], "task": "NER"}
{"text": "The highest TTX content is 10 . 0 microg / g in N . livescens .", "entity": [{"entity": "TTX", "entity_type": "GENE", "pos": [12, 15]}], "task": "NER"}
{"text": "The BUR was set at 20 / min and the IT at . 5 seconds .", "entity": [], "task": "NER"}
{"text": "In this study , to elucidate the possible mechanism of action of EM , we examined the effect of the drug on the expression of neutrophil adhesion molecules such as L - selectin and Mac - 1 .", "entity": [{"entity": "L - selectin", "entity_type": "GENE", "pos": [164, 176]}, {"entity": "Mac - 1", "entity_type": "GENE", "pos": [181, 188]}], "task": "NER"}
{"text": "It contains 31 exons and a high proportion of class 0 introns , alternative splicing of which results in significant levels of variant transcripts that maintain the original open reading frame of MRP mRNA .", "entity": [{"entity": "MRP mRNA", "entity_type": "GENE", "pos": [196, 204]}], "task": "NER"}
{"text": "This nuclear / organellar gene transfer event is strikingly similar to the experimentally accessible process of nuclear integration of introduced heterologous DNA .", "entity": [], "task": "NER"}
{"text": "Under control conditions , pretreatment with lithium during 7 days did not modify the hyperlocomotion produced by d - amphetamine .", "entity": [], "task": "NER"}
{"text": "We also show that the products of both the GIY - YIG ORF and the non - canonical LAGLI - DADG - GIY - YIG ORF , which is generated by its integration , have endonuclease activities which recognize and cut the insertion site of the optional sequence .", "entity": [{"entity": "GIY - YIG", "entity_type": "GENE", "pos": [43, 52]}, {"entity": "LAGLI - DADG - GIY - YIG", "entity_type": "GENE", "pos": [81, 105]}], "task": "NER"}
{"text": "This article describes a program that resulted in a 75 - percent reduction of inventory over a five - year interval .", "entity": [], "task": "NER"}
{"text": "Risk ratios decreased with increasing age and increased with number of breast biopsies , family history of breast cancer , estrogen use , time between screenings , no comparison with previous mammograms , and the radiologist ' s tendency to call mammograms abnormal .", "entity": [], "task": "NER"}
{"text": "The pharmacokinetics were best described by a two - compartment open model giving distribution half - lives of 0 . 31 h and 1 . 53 h , and elimination half - lives of 69 . 7 h and 60 . 3 h for oxolinic acid and oxytetracycline , respectively .", "entity": [], "task": "NER"}
{"text": "However , the relative substrate specificity of RSK3 differed from that reported for other isoforms .", "entity": [{"entity": "RSK3", "entity_type": "GENE", "pos": [48, 52]}], "task": "NER"}
{"text": "This study demonstrates a novel link between alterations in platelet - derived growth factor ( PDGF ) regulation of ornithine decarboxylase ( ODC ) expression during malignant conversion .", "entity": [{"entity": "platelet - derived growth factor", "entity_type": "GENE", "pos": [60, 92]}, {"entity": "PDGF", "entity_type": "GENE", "pos": [95, 99]}, {"entity": "ornithine decarboxylase", "entity_type": "GENE", "pos": [116, 139]}, {"entity": "ODC", "entity_type": "GENE", "pos": [142, 145]}], "task": "NER"}
{"text": "Fosinopril decreased blood pressure from 174 / 101 mm Hg to 149 / 88 mm Hg in patients with diastolic hypertension and from 182 / 86 mm Hg to 151 / 80 mm Hg in patients with ISH .", "entity": [], "task": "NER"}
{"text": "187 - 200 .", "entity": [], "task": "NER"}
{"text": "Loss of pRb or p107 binding results in the loss of transforming activity .", "entity": [{"entity": "pRb", "entity_type": "GENE", "pos": [8, 11]}, {"entity": "p107", "entity_type": "GENE", "pos": [15, 19]}], "task": "NER"}
{"text": "Influence of huanglian used in combination with huangqin and gancao on the erythrocytic osmotic fragilitas of experimental glucose - 6 - phosphate dehydrogenase deficiency in rats ] OBJECTIVE : To study the influence of common combination of Huanglian ( Coptis chinensis ) on the erythrocytic osmotic fragilitas of glucose - 6 - phosphate dehydrogenase ( G6PD ) deficiency in rats .", "entity": [{"entity": "glucose - 6 - phosphate dehydrogenase", "entity_type": "GENE", "pos": [123, 160]}, {"entity": "glucose - 6 - phosphate dehydrogenase", "entity_type": "GENE", "pos": [315, 352]}, {"entity": "G6PD", "entity_type": "GENE", "pos": [355, 359]}], "task": "NER"}
{"text": "Inhibitory receptors are characterized by the presence of a characteristic sequence known as an immunoreceptor tyrosine - based inhibitory motif ( ITIM ) in their cytoplasmic tail .", "entity": [], "task": "NER"}
{"text": "Comparison of Healon and Amvisc .", "entity": [], "task": "NER"}
{"text": "2 , 4 - and 2 , 6 - toluenediamine in hydrolysed plasma and urine after test - chamber exposure of humans to 2 , 4 - and 2 , 6 - toluene diisocyanate .", "entity": [], "task": "NER"}
{"text": "The role of the medical facilities in the prognosis of the patient with tetanus specially the importance of considering at the same time the severity of the disease and the characteristics of the therapy deserve further study in order to contribute to the development of the medical assistance to the patients with tetanus .", "entity": [], "task": "NER"}
{"text": "Interaction between the tobacco DNA - binding activity CBF and the cyt - 1 promoter element of the Agrobacterium tumefaciens T - DNA gene T - CYT correlates with cyt - 1 directed gene expression in multiple tobacco tissue types .", "entity": [{"entity": "CBF", "entity_type": "GENE", "pos": [55, 58]}, {"entity": "cyt - 1 promoter element", "entity_type": "GENE", "pos": [67, 91]}, {"entity": "T - CYT", "entity_type": "GENE", "pos": [138, 145]}, {"entity": "cyt - 1", "entity_type": "GENE", "pos": [162, 169]}], "task": "NER"}
{"text": "These results suggest that repetitive GAA sequences enhance splicing by binding a protein complex containing a sequence - specific RNA binding protein and a general splicing activator that , in turn , recruit additional SR proteins .", "entity": [{"entity": "SR proteins", "entity_type": "GENE", "pos": [220, 231]}], "task": "NER"}
{"text": "Organization of exons suggests that , similar to the human VEGF gene , alternative splicing generates the 120 - , 164 - , and 188 - amino acid isoforms , but does not predict a fourth VEGF isoform corresponding to human VEGF206 .", "entity": [{"entity": "human VEGF gene", "entity_type": "GENE", "pos": [53, 68]}, {"entity": "VEGF isoform", "entity_type": "GENE", "pos": [184, 196]}, {"entity": "human VEGF206", "entity_type": "GENE", "pos": [214, 227]}], "task": "NER"}
{"text": "The papers provide a broad perspective of MPAs and include social , economic , cultural , biological and statistical components .", "entity": [], "task": "NER"}
{"text": "The great cardiac vein flow became zero due to the cardiac arrest and remained at zero for a moment ( dead time ) after the initiation of reperfusion .", "entity": [], "task": "NER"}
{"text": "CONCLUSIONS : These results suggest that histamine - 2 receptor activation mechanisms may not be involved in postoperative IL - 6 synthesis .", "entity": [{"entity": "histamine - 2 receptor", "entity_type": "GENE", "pos": [41, 63]}, {"entity": "IL - 6", "entity_type": "GENE", "pos": [123, 129]}], "task": "NER"}
{"text": "Issues discussed include the validity of the MMPI Mf scale , questions of sample representativeness , whether \" straights \" can do adequate research on homosexuality , differences in heterosexual and homosexual sexuality , the role of subculture acculturation in homosexual psychological adjustment , and the use of cluster - analysis to generate typologies of homosexualities .", "entity": [], "task": "NER"}
{"text": "Our data suggest that some defects observed in BS , WS or RTS are the consequence of unrestrained recombination .", "entity": [], "task": "NER"}
{"text": "LAC9 is a DNA - binding protein that regulates transcription of the lactose - galactose regulon in Kluyveromyces lactis .", "entity": [{"entity": "LAC9", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "lactose - galactose regulon", "entity_type": "GENE", "pos": [68, 95]}], "task": "NER"}
{"text": "Some cells were excited , others inhibited by , and only some were directionally sensitive to the optomotor stimulus .", "entity": [], "task": "NER"}
{"text": "We have cloned the cDNA for the SLBP from humans , mice , and frogs , using the recently developed yeast three - hybrid system .", "entity": [{"entity": "SLBP", "entity_type": "GENE", "pos": [32, 36]}], "task": "NER"}
{"text": "The molecular event ( s ) underlying the functional specificities of these receptors ( in regulating the expression of their native target genes ) is a very important issue that remains poorly understood .", "entity": [], "task": "NER"}
{"text": "Alternative splicing of the human serotonin transporter gene .", "entity": [{"entity": "human serotonin transporter gene", "entity_type": "GENE", "pos": [28, 60]}], "task": "NER"}
{"text": "Nuclear proteins bound the cad + 55 / + 75 element in a cell cycle - dependent manner in electromobility shift assays ; antibodies specific to USF and Max blocked the DNA - binding activity of different growth - regulated protein - DNA complexes .", "entity": [{"entity": "cad + 55 / + 75 element", "entity_type": "GENE", "pos": [27, 50]}, {"entity": "USF", "entity_type": "GENE", "pos": [143, 146]}, {"entity": "Max", "entity_type": "GENE", "pos": [151, 154]}], "task": "NER"}
{"text": "For Thermus strain ZO5 dihydroorotase ( DHOase ; encoded by pyrC ) , the highest similarity scores ( about 40 % identity ) were obtained with DHOases from B . caldolyticus and Bacillus subtilis .", "entity": [{"entity": "ZO5 dihydroorotase", "entity_type": "GENE", "pos": [19, 37]}, {"entity": "DHOase", "entity_type": "GENE", "pos": [40, 46]}, {"entity": "pyrC", "entity_type": "GENE", "pos": [60, 64]}, {"entity": "DHOases", "entity_type": "GENE", "pos": [142, 149]}], "task": "NER"}
{"text": "This difference between SP - 1 and SP - 2 peptides was not due to their differential uptake by cell , since approximately 100 times more SP - 2 peptide could be found in cytoplasmic extracts than SP - 1 peptide in experiments using radiolabeled peptides .", "entity": [{"entity": "SP - 1", "entity_type": "GENE", "pos": [24, 30]}, {"entity": "SP - 2 peptides", "entity_type": "GENE", "pos": [35, 50]}, {"entity": "SP - 2 peptide", "entity_type": "GENE", "pos": [137, 151]}, {"entity": "SP - 1 peptide", "entity_type": "GENE", "pos": [196, 210]}], "task": "NER"}
{"text": "The product of one gene , Bv80 , has a single divergent copy of a sequence of 149 amino acids ( approx .", "entity": [{"entity": "Bv80", "entity_type": "GENE", "pos": [26, 30]}], "task": "NER"}
{"text": "The carboxy - proximal regions of the VP1 , which contain very low amino acid homology , displayed evidence of conservation in structural features such as a hydrophilic , highly basic domain .", "entity": [{"entity": "VP1", "entity_type": "GENE", "pos": [38, 41]}], "task": "NER"}
{"text": "The sequences at - 10 and - 35 relative to the transcriptional starting site showed 55 % homology with the consensus sequences of the Escherichia coli sigma 70 - type promoter .", "entity": [{"entity": "Escherichia coli sigma 70 - type promoter", "entity_type": "GENE", "pos": [134, 175]}], "task": "NER"}
{"text": "The two ORFs had significant similarity with the putative replication protein from plasmid pTiK12 of Thiobacillus intermedius and other CoIE2 - related plasmids .", "entity": [], "task": "NER"}
{"text": "A clinical double - blind trial of topical miconazole and clotrimazole against superficial fungal infections and erythrasma .", "entity": [], "task": "NER"}
{"text": "Lumbar spine bone mineral density ( BMD ) by dual - energy X - ray absorptiometry ( DXA ) increased by 0 . 6 % , 3 . 6 % and 8 . 1 % after 48 weeks in groups L , M and H respectively , responses in groups M and H being significantly higher than in L ( p < 0 . 05 , Mann - Whitney U - test ) .", "entity": [], "task": "NER"}
{"text": "A genomic clone representing the 5 ' part of the message was also isolated .", "entity": [], "task": "NER"}
{"text": "This unusual behaviour may be explained by the 18 amino acid - long CDR - H3 and could be of value in the design of ' single domain ' antibodies .", "entity": [{"entity": "18 amino acid - long CDR - H3", "entity_type": "GENE", "pos": [47, 76]}], "task": "NER"}
{"text": "Bleeding was successfully prevented in 28 patients with the use of a combined treatment incorporating IV desmopressin , an antifibrinolytic agent ( tranexamic acid ) , and local methods ( surgical glue and compression techniques ) .", "entity": [], "task": "NER"}
{"text": "Northern blot analysis demonstrated that the genes are transcribed separately .", "entity": [], "task": "NER"}
{"text": "CONCLUSIONS : Systemic factors that increase bone mineral density appear to be involved in the pathogenesis of ossification of the posterior longitudinal ligament , and these factors may be activated after middle age .", "entity": [], "task": "NER"}
{"text": "FdsR purified to homogeneity after overexpression of fdsR in E . coli is a 130 kDa homotetramer binding to the fds control region located between the fdsR and fdsG genes .", "entity": [{"entity": "FdsR", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "fdsR", "entity_type": "GENE", "pos": [53, 57]}, {"entity": "fds", "entity_type": "GENE", "pos": [111, 114]}, {"entity": "fdsR", "entity_type": "GENE", "pos": [150, 154]}, {"entity": "fdsG genes", "entity_type": "GENE", "pos": [159, 169]}], "task": "NER"}
{"text": "Surgical methods in the treatment of rhinophyma .", "entity": [], "task": "NER"}
{"text": "The adeno - associated virus type 2 ( AAV - 2 ) Rep78 / Rep68 regulatory proteins are pleiotropic effectors of viral and cellular DNA replication , of cellular transformation by viral and cellular oncogenes , and of homologous and heterologous gene expression .", "entity": [{"entity": "Rep78", "entity_type": "GENE", "pos": [48, 53]}, {"entity": "Rep68", "entity_type": "GENE", "pos": [56, 61]}], "task": "NER"}
{"text": "We show here that Spb1p is able to bind [ ( 3 ) H ] AdoMet in vitro , suggesting that it is a novel methylase , whose possible substrates will be discussed .", "entity": [{"entity": "Spb1p", "entity_type": "GENE", "pos": [18, 23]}], "task": "NER"}
{"text": "Low temperature ( 8 degrees C ) impairs secretory activity , again independently of the photoperiod selected .", "entity": [], "task": "NER"}
{"text": "These data suggest that weight gain or increased caloric intake , in contrast to its large effect on peripheral thyroid function , has relatively little effect on CNS TRH activity .", "entity": [{"entity": "CNS TRH", "entity_type": "GENE", "pos": [163, 170]}], "task": "NER"}
{"text": "Hematopoietic progenitor kinase 1 ( HPK1 ) is a member of the mitogen - activated protein kinase kinase kinase kinase ( MAP4K ) family and an upstream activator of the c - Jun N - terminal kinase ( JNK ) signaling cascade .", "entity": [{"entity": "Hematopoietic progenitor kinase 1", "entity_type": "GENE", "pos": [0, 33]}, {"entity": "HPK1", "entity_type": "GENE", "pos": [36, 40]}, {"entity": "mitogen - activated protein kinase kinase kinase kinase", "entity_type": "GENE", "pos": [62, 117]}, {"entity": "MAP4K", "entity_type": "GENE", "pos": [120, 125]}, {"entity": "c - Jun N - terminal kinase", "entity_type": "GENE", "pos": [168, 195]}, {"entity": "JNK", "entity_type": "GENE", "pos": [198, 201]}], "task": "NER"}
{"text": "We conclude that the outcome of patients with uterine MMMT is mainly influenced by the initial stage and the type of epithelial component .", "entity": [], "task": "NER"}
{"text": "Increased susceptibility of aphasics to a distractor task in the recall of verbal commands .", "entity": [], "task": "NER"}
{"text": "Here we show that inhibition occurs with a NS1 - Rev chimera in which the 78 amino - terminal amino acids of the NS1A protein comprising its entire RNA - binding domain is deleted , thereby establishing that this carboxyl portion of the NS1A protein can function as an independent effector domain .", "entity": [{"entity": "NS1", "entity_type": "GENE", "pos": [43, 46]}, {"entity": "Rev", "entity_type": "GENE", "pos": [49, 52]}, {"entity": "NS1A protein", "entity_type": "GENE", "pos": [113, 125]}, {"entity": "NS1A protein", "entity_type": "GENE", "pos": [237, 249]}], "task": "NER"}
{"text": "We hypothesized that conjugated estrogens , which contain several vasoactive estrogenic compounds , may favorably influence the vasomotor response to acetylcholine in men .", "entity": [], "task": "NER"}
{"text": "Calcium bilirubinate crystals were seen in gallbladder bile or wall scrapings of 7 of 8 TPN animals but in none of the controls ( P less than 0 . 001 ) .", "entity": [], "task": "NER"}
{"text": "Because c - myb encodes a transcriptional activator that functions via DNA binding , it is likely that c - myb exerts its biological activity by regulating the transcription of genes required for DNA synthesis and cell cycle progression .", "entity": [{"entity": "c - myb", "entity_type": "GENE", "pos": [8, 15]}, {"entity": "c - myb", "entity_type": "GENE", "pos": [103, 110]}], "task": "NER"}
{"text": "Alcohol and stomach diseases", "entity": [], "task": "NER"}
{"text": "Thus integration host factor is required for normal type 1 fimbriae phase variation in E . coli .", "entity": [{"entity": "integration host factor", "entity_type": "GENE", "pos": [5, 28]}, {"entity": "type 1 fimbriae", "entity_type": "GENE", "pos": [52, 67]}], "task": "NER"}
{"text": "Multiple attempts aimed at disruption of the chromosomal fabG gene were unsuccessful .", "entity": [{"entity": "chromosomal fabG gene", "entity_type": "GENE", "pos": [45, 66]}], "task": "NER"}
{"text": "In our case the development of the tumor at the posterior side of the prostate , the lack of PSA immunoreactivity and the presence of mucinous glands , sometimes \" endocervical - like \" , could suggest an origin from embryonic mullerian remnants in the prostatic utricle rather than urogenital sinus .", "entity": [{"entity": "PSA", "entity_type": "GENE", "pos": [93, 96]}], "task": "NER"}
{"text": "Analysis of the DNA - binding and transcriptional activation functions of human Fli - 1 protein .", "entity": [{"entity": "human Fli - 1 protein", "entity_type": "GENE", "pos": [74, 95]}], "task": "NER"}
{"text": "The second patient was successfully treated with intravenous prostaglandin F2 alpha ( PGF2 alpha ) .", "entity": [], "task": "NER"}
{"text": "Salts of these four metal ions may be added to the growth medium to facilitate selective isolation of Acinetobacter .", "entity": [], "task": "NER"}
{"text": "DESIGN - - A randomised double blind placebo controlled parallel arm trial .", "entity": [], "task": "NER"}
{"text": "Base substitutions within this NFIL - 6 site resulted in virtual elimination of LPS - induced IL - 1 beta gene transcription .", "entity": [{"entity": "NFIL - 6 site", "entity_type": "GENE", "pos": [31, 44]}, {"entity": "IL - 1 beta gene", "entity_type": "GENE", "pos": [94, 110]}], "task": "NER"}
{"text": "Different clinical variants of the empty sella turcica syndrome are demonstrated , including variants resultant from substitution therapy of thyroid hypofunction , from dopamine agonist therapy for hyperprolactinemic hypogonadism , from radiotherapy of hypophyseal adenoma .", "entity": [], "task": "NER"}
{"text": "Repeated time course studies in the same patient were reproducible although the absolute concentrations showed some variation .", "entity": [], "task": "NER"}
{"text": "Our data suggest that association of TBP with the TATA box may be regulated , directly or indirectly , by a substrate of Snf1 .", "entity": [{"entity": "TBP", "entity_type": "GENE", "pos": [37, 40]}, {"entity": "Snf1", "entity_type": "GENE", "pos": [121, 125]}], "task": "NER"}
{"text": "Site - directed mutagenesis of the T4 endonuclease V gene : role of lysine - 130 .", "entity": [{"entity": "T4 endonuclease V gene", "entity_type": "GENE", "pos": [35, 57]}], "task": "NER"}
{"text": "Simulations of velocities , vorticity , pressure and certain stress values were developed by a computer and displayed for man - machine interaction .", "entity": [], "task": "NER"}
{"text": "Together , these results implicate Fal1p in the 18S rRNA maturation pathway rather than in translation initiation .", "entity": [{"entity": "Fal1p", "entity_type": "GENE", "pos": [35, 40]}, {"entity": "18S rRNA", "entity_type": "GENE", "pos": [48, 56]}], "task": "NER"}
{"text": "TRAF2 has previously been demonstrated to activate both transcription factor nuclear factor kappaB ( NFkappaB ) and the c - Jun N - terminal kinase / stress - activated protein kinase ( JNK / SAPK ) pathway , which in turn stimulates transcription factor activating protein 1 ( AP1 ) mainly via phosphorylation of the c - Jun component .", "entity": [{"entity": "TRAF2", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "nuclear factor kappaB", "entity_type": "GENE", "pos": [77, 98]}, {"entity": "NFkappaB", "entity_type": "GENE", "pos": [101, 109]}, {"entity": "c - Jun N - terminal kinase", "entity_type": "GENE", "pos": [120, 147]}, {"entity": "stress - activated protein kinase", "entity_type": "GENE", "pos": [150, 183]}, {"entity": "JNK", "entity_type": "GENE", "pos": [186, 189]}, {"entity": "SAPK", "entity_type": "GENE", "pos": [192, 196]}, {"entity": "transcription factor activating protein 1", "entity_type": "GENE", "pos": [234, 275]}, {"entity": "AP1", "entity_type": "GENE", "pos": [278, 281]}, {"entity": "c - Jun", "entity_type": "GENE", "pos": [318, 325]}], "task": "NER"}
{"text": "Electrophysiology and pharmacology of epicardial , endocardial , and M cells .", "entity": [], "task": "NER"}
{"text": "The data suggest that compromised fibrinolytic capacity may be a contributing factor in the development of thrombosis in patients with the lupus anticoagulant .", "entity": [], "task": "NER"}
{"text": "Human psychophysical analysis of receptive field - like properties - - II .", "entity": [], "task": "NER"}
{"text": "Furthermore , agonist action at a 5 - HT1 receptor and antagonist action at 5 - HT2 receptors both appear to contribute to antidepressant - like activity on the DRL 72 - s schedule .", "entity": [{"entity": "5 - HT1 receptor", "entity_type": "GENE", "pos": [34, 50]}, {"entity": "5 - HT2 receptors", "entity_type": "GENE", "pos": [76, 93]}], "task": "NER"}
{"text": "Heliox improves pulsus paradoxus and peak expiratory flow in nonintubated patients with severe asthma .", "entity": [], "task": "NER"}
{"text": "Response surface methodology was employed to describe the relationship between soman - induced incapacitation and the ATR / DZ or ATR / SCP dosages .", "entity": [], "task": "NER"}
{"text": "Both DMP2 and DMP3 are closely localized on mouse chromosome 5q21 , corresponding to human chromosome 4q21 .", "entity": [{"entity": "DMP2", "entity_type": "GENE", "pos": [5, 9]}, {"entity": "DMP3", "entity_type": "GENE", "pos": [14, 18]}], "task": "NER"}
{"text": "A kinetic model for 99mTc - DMSA in the rat .", "entity": [], "task": "NER"}
{"text": "Together with the up - regulation of the cAMP response element modulator protein ( CREM ) mRNA and protein levels demonstrated previously in CREB mutant mice , we suggest that the up - regulation of CREB beta may also contribute to compensation within the CREB / ATF family of transcription factors , when CREB delta and CREB alpha are absent .", "entity": [{"entity": "cAMP response element modulator protein", "entity_type": "GENE", "pos": [41, 80]}, {"entity": "CREM", "entity_type": "GENE", "pos": [83, 87]}, {"entity": "CREB mutant", "entity_type": "GENE", "pos": [141, 152]}, {"entity": "CREB beta", "entity_type": "GENE", "pos": [199, 208]}, {"entity": "CREB", "entity_type": "GENE", "pos": [256, 260]}, {"entity": "ATF", "entity_type": "GENE", "pos": [263, 266]}, {"entity": "CREB delta", "entity_type": "GENE", "pos": [306, 316]}, {"entity": "CREB alpha", "entity_type": "GENE", "pos": [321, 331]}], "task": "NER"}
{"text": "To examine the effect of the cAMP signal transduction pathway on transcription of the gene encoding the catalytic subunit of glucose - 6 - phosphatase ( G6Pase ) , G6Pase - chloramphenicol acetyltransferase ( CAT ) fusion genes were transiently transfected into either the liver - derived HepG2 or kidney - derived LLC - PK cell line .", "entity": [{"entity": "glucose - 6 - phosphatase", "entity_type": "GENE", "pos": [125, 150]}, {"entity": "G6Pase", "entity_type": "GENE", "pos": [153, 159]}, {"entity": "G6Pase", "entity_type": "GENE", "pos": [164, 170]}, {"entity": "chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [173, 206]}, {"entity": "CAT", "entity_type": "GENE", "pos": [209, 212]}], "task": "NER"}
{"text": "The structural intestinal defects are presumed to be the result of defective collagen synthesis in these hereditary connective tissue disorders .", "entity": [{"entity": "collagen", "entity_type": "GENE", "pos": [77, 85]}], "task": "NER"}
{"text": "Letter : Dehydrated test strip for the detection of yeasts .", "entity": [], "task": "NER"}
{"text": "Galactorrhoea is a rare presentation of an empty sella syndrome .", "entity": [], "task": "NER"}
{"text": "The transition from expression of early meiotic genes to expression of middle sporulation - specific genes occurs at about the time that cells exit from pachytene and form the meiosis I spindle .", "entity": [], "task": "NER"}
{"text": "Mutations away from splice site recognition sequences might cis - modulate alternative splicing of goat alpha s1 - casein transcripts .", "entity": [{"entity": "alpha s1 - casein transcripts", "entity_type": "GENE", "pos": [104, 133]}], "task": "NER"}
{"text": "These Tlr family members , unlike others reported to date , were identified within a genomic database .", "entity": [{"entity": "Tlr family members", "entity_type": "GENE", "pos": [6, 24]}], "task": "NER"}
{"text": "Fig1p and Fig2p are likely to act at the cell surface as Fig1 : : beta - gal and Fig2 : : beta - gal fusion proteins localize to the periphery of mating cells .", "entity": [{"entity": "Fig1p", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "Fig2p", "entity_type": "GENE", "pos": [10, 15]}, {"entity": "Fig1", "entity_type": "GENE", "pos": [57, 61]}, {"entity": "beta - gal", "entity_type": "GENE", "pos": [66, 76]}, {"entity": "Fig2", "entity_type": "GENE", "pos": [81, 85]}, {"entity": "beta - gal fusion proteins", "entity_type": "GENE", "pos": [90, 116]}], "task": "NER"}
{"text": "There is little supportive evidence that ACE inhibitors ( captopril or enalapril ) are teratogenic .", "entity": [{"entity": "ACE", "entity_type": "GENE", "pos": [41, 44]}], "task": "NER"}
{"text": "Evaluation of gamma - glutamyl transpeptidase in myocardial infarction .", "entity": [{"entity": "gamma - glutamyl transpeptidase", "entity_type": "GENE", "pos": [14, 45]}], "task": "NER"}
{"text": "The yjr041c delta haploid cells gave rise to microcolonies comprising about 20 to 50 cells .", "entity": [{"entity": "yjr041c delta", "entity_type": "GENE", "pos": [4, 17]}], "task": "NER"}
{"text": "Mean latency periods were 29 . 6 among insulators , 35 . 4 among dock workers , 43 . 7 in a heterogeneous group defined as various , 46 . 4 in non - shipbuilding industry workers , 49 . 4 in shipyard workers , 51 . 7 among women with a history of domestic exposure to asbestos , and 56 . 2 in people employed in maritime trades .", "entity": [], "task": "NER"}
{"text": "Influence of dietary supplementation with Streptococcus faecium M - 74 on broiler body weight , feed conversion , carcass characteristics , and intestinal microbial colonization .", "entity": [], "task": "NER"}
{"text": "Two plasmids , one containing the amino terminus of P fused to the DNA - binding domain of the yeast transactivator , GAL4 , and the other containing the amino terminus of NP fused to the herpesvirus transactivator , VP16 , were transfected in COS - 1 cells along with a chloramphenicol acetyltransferase ( CAT ) reporter plasmid containing GAL4 DNA - binding sites .", "entity": [{"entity": "GAL4", "entity_type": "GENE", "pos": [118, 122]}, {"entity": "NP", "entity_type": "GENE", "pos": [172, 174]}, {"entity": "VP16", "entity_type": "GENE", "pos": [217, 221]}, {"entity": "chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [271, 304]}, {"entity": "CAT", "entity_type": "GENE", "pos": [307, 310]}, {"entity": "GAL4", "entity_type": "GENE", "pos": [341, 345]}], "task": "NER"}
{"text": "7 - Nitroindazole ( 7NI ) , a relatively selective neuronal nitric oxide synthase ( nNOS ) inhibitor . was intraperitoneally administered to the guinea pigs 30 minutes before the onset of local anoxia .", "entity": [{"entity": "nitric oxide synthase", "entity_type": "GENE", "pos": [60, 81]}, {"entity": "nNOS", "entity_type": "GENE", "pos": [84, 88]}], "task": "NER"}
{"text": "New protein - free products for diet therapy in chronic renal insufficiency", "entity": [], "task": "NER"}
{"text": "Impact of cytokine gene polymorphisms on outcomes of coronary artery bypass graft surgery .", "entity": [], "task": "NER"}
{"text": "The human protein binds most strongly to the SH3 domain from the abl proto - oncogene .", "entity": [{"entity": "SH3 domain", "entity_type": "GENE", "pos": [45, 55]}, {"entity": "abl proto - oncogene", "entity_type": "GENE", "pos": [65, 85]}], "task": "NER"}
{"text": "Adequacy of the Haldane transformation in the computation of exercise V O2 in man .", "entity": [], "task": "NER"}
{"text": "Covariates were lower extremity range of motion and sensory status .", "entity": [], "task": "NER"}
{"text": "Like troponin Cs and calmodulins , PfCPK also contains four EF hand calcium - binding motifs .", "entity": [{"entity": "troponin Cs", "entity_type": "GENE", "pos": [5, 16]}, {"entity": "calmodulins", "entity_type": "GENE", "pos": [21, 32]}, {"entity": "PfCPK", "entity_type": "GENE", "pos": [35, 40]}], "task": "NER"}
{"text": "Roller pumps , coronary suction and an open cardiotomy reservoir were used .", "entity": [], "task": "NER"}
{"text": "Akt - dependent antiapoptotic action of insulin is sensitive to farnesyltransferase inhibitor .", "entity": [{"entity": "Akt", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "insulin", "entity_type": "GENE", "pos": [40, 47]}], "task": "NER"}
{"text": "LT - beta transcription is maximal in the thymic medulla and in splenic white pulp .", "entity": [{"entity": "LT - beta", "entity_type": "GENE", "pos": [0, 9]}], "task": "NER"}
{"text": "Ultrastructure and toxin formation of Cor . diphtheriae PW - 8 cultured in the presence of penicillin", "entity": [], "task": "NER"}
{"text": "Our data indicate that the various subunits of the human P - TEFb complex may play distinct roles at multiple stages to mediate Tat activation of HIV - 1 transcription elongation .", "entity": [{"entity": "P - TEFb", "entity_type": "GENE", "pos": [57, 65]}, {"entity": "Tat", "entity_type": "GENE", "pos": [128, 131]}], "task": "NER"}
{"text": "The organelles synthesize their own set of Fe / S proteins , and they initiate the generation of extramitochondrial Fe / S proteins .", "entity": [{"entity": "Fe / S proteins", "entity_type": "GENE", "pos": [43, 58]}, {"entity": "extramitochondrial Fe / S proteins", "entity_type": "GENE", "pos": [97, 131]}], "task": "NER"}
{"text": "Ras involvement in signal transduction by the serotonin 5 - HT2B receptor .", "entity": [{"entity": "Ras", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "serotonin 5 - HT2B receptor", "entity_type": "GENE", "pos": [46, 73]}], "task": "NER"}
{"text": "Engineering temperature - sensitive SH3 domains .", "entity": [{"entity": "SH3 domains", "entity_type": "GENE", "pos": [36, 47]}], "task": "NER"}
{"text": "Orlistat is a specific lipase inhibitor that impairs fat absorption , thereby reducing fat uptake .", "entity": [{"entity": "lipase", "entity_type": "GENE", "pos": [23, 29]}], "task": "NER"}
{"text": "We identify YY1 recognition sequences within the vitamin D response element ( VDRE ) of the osteocalcin gene that are critical for YY1 - dependent repression of vitamin D - enhanced promoter activity .", "entity": [{"entity": "YY1", "entity_type": "GENE", "pos": [12, 15]}, {"entity": "osteocalcin gene", "entity_type": "GENE", "pos": [92, 108]}, {"entity": "YY1", "entity_type": "GENE", "pos": [131, 134]}], "task": "NER"}
{"text": "The nine subjects were treated in random sequence with cimetidine 0 - 8 - 1 - 0 g on one day and placebo capsules on the other .", "entity": [], "task": "NER"}
{"text": "ORF3 encodes a putative periplasmic c - type cytochrome with a molecular mass of 94 , 000 Da and contains seven c - heme - binding motifs but shows no sequence homology to occ or ORF1 .", "entity": [{"entity": "periplasmic c - type cytochrome", "entity_type": "GENE", "pos": [24, 55]}, {"entity": "occ", "entity_type": "GENE", "pos": [172, 175]}], "task": "NER"}
{"text": "The mutant strain carries three tandem copies of the 18 bp sequence that is duplicated in the amdI66 mutation .", "entity": [{"entity": "amdI66", "entity_type": "GENE", "pos": [94, 100]}], "task": "NER"}
{"text": "The rat anococcygeus muscle was used in postsynaptic studies .", "entity": [], "task": "NER"}
{"text": "The HPV E1 and E2 proteins along with cellular factors , are required for replication of the viral genome .", "entity": [{"entity": "E1", "entity_type": "GENE", "pos": [8, 10]}, {"entity": "E2", "entity_type": "GENE", "pos": [15, 17]}], "task": "NER"}
{"text": "Multiple organ failure ( MOF ) following major trauma occurs in response to perfusion deficits , a persistent inflammatory focus , or a persistent focus of dead and / or injured tissue .", "entity": [], "task": "NER"}
{"text": "( i ) Several ribosomal proteins were synthesized in substantial excess .", "entity": [], "task": "NER"}
{"text": "These results suggest that camptothecin resistance in CEM / DOX cells is due to different mechanism ( s ) than topoisomerase - or P - glycoprotein - associated multidrug resistance .", "entity": [{"entity": "topoisomerase", "entity_type": "GENE", "pos": [111, 124]}, {"entity": "P - glycoprotein", "entity_type": "GENE", "pos": [130, 146]}], "task": "NER"}
{"text": "The detection limits obtained by using the mixed eluent were 0 . 05 - 0 . 13 mg / L , several times lower than those obtained by using single KHPh eluent .", "entity": [], "task": "NER"}
{"text": "Here we report the fabrication of single - molecule transistors based on individual C60 molecules connected to gold electrodes .", "entity": [], "task": "NER"}
{"text": "Because of gut fermentation , a substantial portion ( 16 - 80 % ) of N is absorbed as ammonia N ( NH3N ) .", "entity": [], "task": "NER"}
{"text": "At 1 min postalfentanil , N2O caused significantly more rigidity than 100 % O2 ( p < 0 . 001 ) .", "entity": [], "task": "NER"}
{"text": "By contrast , CIS failed to affect the IL - 9 response .", "entity": [{"entity": "CIS", "entity_type": "GENE", "pos": [14, 17]}, {"entity": "IL - 9", "entity_type": "GENE", "pos": [39, 45]}], "task": "NER"}
{"text": "Interestingly , PMA - , PDGF - , and serum - induced GHR proteolysis was associated with substantial decreases in GH - induced activation of Janus kinase - 2 , which were also prevented by IC3 .", "entity": [{"entity": "PDGF", "entity_type": "GENE", "pos": [24, 28]}, {"entity": "GHR", "entity_type": "GENE", "pos": [53, 56]}, {"entity": "GH", "entity_type": "GENE", "pos": [114, 116]}, {"entity": "Janus kinase - 2", "entity_type": "GENE", "pos": [141, 157]}], "task": "NER"}
{"text": "The centromeric dodeca - satellite of Drosophila forms altered DNA structures in vitro in which its purine - rich strand ( G - strand ) forms stable fold - back structures , while the complementary C - strand remains unstructured .", "entity": [], "task": "NER"}
{"text": "The Aspergillus uvsH gene encodes a product homologous to yeast RAD18 and Neurospora UVS - 2 .", "entity": [{"entity": "Aspergillus uvsH gene", "entity_type": "GENE", "pos": [4, 25]}, {"entity": "yeast RAD18", "entity_type": "GENE", "pos": [58, 69]}, {"entity": "Neurospora UVS - 2", "entity_type": "GENE", "pos": [74, 92]}], "task": "NER"}
{"text": "These data also suggest the existence of a mechanism by which regulatory subunits modulate the PI 3 - kinase - mediated signals , independent of the kinase activity , possibly through subcellular localization of the catalytic subunit or interaction with additional signaling molecules .", "entity": [{"entity": "PI 3 - kinase", "entity_type": "GENE", "pos": [95, 108]}], "task": "NER"}
{"text": "A continuous - flow BIPAP system consists of a high - flow CPAP system , a reservoir bag , and a pneumatically controlled membrane valve in the expiratory limb .", "entity": [], "task": "NER"}
{"text": "This study demonstrates that the exposure to sulphur mustard results in very low androgen levels and hypo - responsiveness to GnRH in the first five weeks and normalization by the twelfth week after injury .", "entity": [{"entity": "GnRH", "entity_type": "GENE", "pos": [126, 130]}], "task": "NER"}
{"text": "The A3B3 domain had a mass of 34 , 462 , with a glycosylation mass of 14 , 900 , in good agreement with seven N - linked glycosylation sites of average mass 2100 .", "entity": [], "task": "NER"}
{"text": "In the present study we prospectively compared side effects occurring in 12 patients after the first administration of low - dose OKT3 ( 0 . 5 mg twice daily ) induction therapy with those in 10 patients who were treated with a conventional dose of OKT3 ( 5 mg daily ) for acute rejection .", "entity": [], "task": "NER"}
{"text": "Plasma prolactin concentrations during incubation , 25 . 8 + / - 2 . 3 ng / ml , decreased to baseline levels , 10 . 8 + / - 1 . 9 ng / ml , within 24 hr after nestbox removal .", "entity": [{"entity": "Plasma prolactin", "entity_type": "GENE", "pos": [0, 16]}], "task": "NER"}
{"text": "Our findings suggest that resting Tl - 201 scintigraphy has limited value in the detection of coronary artery disease in patients with Hurler syndrome .", "entity": [], "task": "NER"}
{"text": "Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation , and is associated with localized dephosphorylation .", "entity": [{"entity": "cyclin", "entity_type": "GENE", "pos": [75, 81]}], "task": "NER"}
{"text": "Also , residues 273 to 287 , which are identical in sequence to a 15 - amino - acid segment near the carboxy terminus of the simian foamy virus transcriptional activator Taf , can independently enhance the activity of the minimal activator region .", "entity": [{"entity": "simian foamy virus transcriptional activator Taf", "entity_type": "GENE", "pos": [125, 173]}], "task": "NER"}
{"text": "The effect of buthionine sulfoximine ( BSO ) and disulfiram ( DSF ) on the urotoxicity induced by cyclophosphamide ( CPA ) was examined in mice .", "entity": [], "task": "NER"}
{"text": "METHOD : Six instruments were reviewed : the Berg Balance Scale ( Berg ) , the Clinical Test of Sensory Interaction and Balance ( CTSIB ) , the Functional Reach Test , the Tinetti Balance Test of the Performance - Oriented Assessment of Mobility Problems ( Tinetti ) , the Timed \" Up and Go \" Test ( TU & GT ) , and the Physical Performance Test ( PPT ) .", "entity": [], "task": "NER"}
{"text": "The side effect of pulmonary fibrosis occurs in 20 to 30 percent of patients receiving this drug .", "entity": [], "task": "NER"}
{"text": "Of the 47 women with AGCUS , 16 had intraepithelial or invasive neoplasms ( 34 % ; 95 % confidence interval , 21 - 49 % ) , including 9 low or high grade squamous intraepithelial lesions , 1 adenocarcinoma in situ of the cervix , 3 adenocarcinomas of the cervix , 2 adenocarcinomas of the endometrium and 1 adenoid basal cell carcinoma of the cervix .", "entity": [], "task": "NER"}
{"text": "Interestingly , these \" activation - defective \" mutants segregated into two classes : 1 ) those that were unable to form dimers but that could still form higher order oligomers and transform cells , and 2 ) those that were defective for PDGF - R binding and were transformation - incompetent .", "entity": [{"entity": "PDGF - R", "entity_type": "GENE", "pos": [238, 246]}], "task": "NER"}
{"text": "Thus in this study we used in vitro methods to directly evaluate whether isolated human saphenous vein segments respond to vasoconstrictor agents at arterial pressure levels .", "entity": [], "task": "NER"}
{"text": "Genomic Southern blot analysis suggests that the human haploid genome contains a single Gs alpha gene .", "entity": [{"entity": "Gs alpha gene", "entity_type": "GENE", "pos": [88, 101]}], "task": "NER"}
{"text": "Four cDNAs ( Kox4 , Kox7 , Kox12 , and Kox15 ) were identified that match one or more genomic clones ; these matches were confirmed by nucleotide sequence analysis .", "entity": [{"entity": "Kox4", "entity_type": "GENE", "pos": [13, 17]}, {"entity": "Kox7", "entity_type": "GENE", "pos": [20, 24]}, {"entity": "Kox12", "entity_type": "GENE", "pos": [27, 32]}, {"entity": "Kox15", "entity_type": "GENE", "pos": [39, 44]}], "task": "NER"}
{"text": "The facilitation started preceding the onset of electromyographic activity of the masseter muscle .", "entity": [], "task": "NER"}
{"text": "Reactivation of hepatitis B virus replication is a rare event during the natural history of chronic hepatitis B .", "entity": [], "task": "NER"}
{"text": "SETTING - - Hospital laboratories in the United States submitting pneumococcal isolates to the CDC between October 1 , 1991 , and September 30 , 1992 .", "entity": [], "task": "NER"}
{"text": "To determine whether transcription of orfX and vfr are controlled by the same mechanisms that control transcription of the region of the divergent ORF ( dorf ) and of crp , we compared the vfr - orfX and crp - dorf intergenic regions .", "entity": [{"entity": "vfr", "entity_type": "GENE", "pos": [47, 50]}, {"entity": "crp", "entity_type": "GENE", "pos": [167, 170]}, {"entity": "vfr", "entity_type": "GENE", "pos": [189, 192]}, {"entity": "crp", "entity_type": "GENE", "pos": [204, 207]}], "task": "NER"}
{"text": "Cotransfection with C / EBPbeta and GATA - 1 expression vectors produced a 5 - fold increase compared with cotransfection with the C / EBPbeta or GATA - 1 expression vectors individually .", "entity": [{"entity": "C / EBPbeta", "entity_type": "GENE", "pos": [20, 31]}, {"entity": "GATA - 1", "entity_type": "GENE", "pos": [36, 44]}, {"entity": "C / EBPbeta", "entity_type": "GENE", "pos": [131, 142]}, {"entity": "GATA - 1", "entity_type": "GENE", "pos": [146, 154]}], "task": "NER"}
{"text": "One of these clones encodes Xenopus N - ras .", "entity": [{"entity": "Xenopus N - ras", "entity_type": "GENE", "pos": [28, 43]}], "task": "NER"}
{"text": "Eighteen patients with advanced epidermoid carcinoma of the head and neck were entered into a phase II trial of N - Methylformamide ( NMF ) , 800 mg / M2 IV daily for 5 days every 4 weeks .", "entity": [], "task": "NER"}
{"text": "Total body water and distribution space of Na24 in women with various body weight", "entity": [], "task": "NER"}
{"text": "Transient cotransfection analyses indicate that the cooperative association of NF - IL - 6 and RelA with the IL - 8 promoter results in synergistic transcriptional activation .", "entity": [{"entity": "NF - IL - 6", "entity_type": "GENE", "pos": [79, 90]}, {"entity": "RelA", "entity_type": "GENE", "pos": [95, 99]}, {"entity": "IL - 8 promoter", "entity_type": "GENE", "pos": [109, 124]}], "task": "NER"}
{"text": "Sera from 33 newborn infants with gestational ages ranging from 27 to 41 weeks were tested by radioimmunoassay for IgG antibodies to surface antigens of group B streptococci ( GBS ) types Ia , Ib , II and III .", "entity": [{"entity": "IgG", "entity_type": "GENE", "pos": [115, 118]}], "task": "NER"}
{"text": "On average , rCMRglc values were 23 % below control values for all regions studied , with the greatest differences in posterior brain regions ( visual association cortex , primary visual cortex , and parietal cortex ) and thalamus .", "entity": [], "task": "NER"}
{"text": "The NF1 family members and HNF4 interacted with overlapping sequences of the L - II element , wherein the 5 ' half - site was more critical for NF1 binding , and the 3 ' site was more important for HNF4 binding .", "entity": [{"entity": "NF1 family", "entity_type": "GENE", "pos": [4, 14]}, {"entity": "HNF4", "entity_type": "GENE", "pos": [27, 31]}, {"entity": "NF1", "entity_type": "GENE", "pos": [144, 147]}, {"entity": "HNF4", "entity_type": "GENE", "pos": [198, 202]}], "task": "NER"}
{"text": "The shear bond strength recorded for the Novabond system was significantly lower ( 17 MPa ) .", "entity": [], "task": "NER"}
{"text": "The IR4 ORF exhibits significant homology to the immediate - early gene US1 ( ICP22 ) of herpes simplex virus type 1 and to the ICP22 homologs of varicella - zoster virus ( ORF63 ) , pseudorabies virus ( RSp40 ) , and equine herpesvirus 4 ( ORF4 ) .", "entity": [{"entity": "immediate - early gene", "entity_type": "GENE", "pos": [49, 71]}, {"entity": "US1", "entity_type": "GENE", "pos": [72, 75]}, {"entity": "ICP22", "entity_type": "GENE", "pos": [78, 83]}, {"entity": "ICP22", "entity_type": "GENE", "pos": [128, 133]}, {"entity": "ORF63", "entity_type": "GENE", "pos": [173, 178]}, {"entity": "RSp40", "entity_type": "GENE", "pos": [204, 209]}], "task": "NER"}
{"text": "Psoriasis on tumor .", "entity": [], "task": "NER"}
{"text": "VP4 differentially regulates TRAF2 signaling , disengaging JNK activation while directing NF - kappa B to effect rotavirus - specific cellular responses .", "entity": [{"entity": "VP4", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "TRAF2", "entity_type": "GENE", "pos": [29, 34]}, {"entity": "JNK", "entity_type": "GENE", "pos": [59, 62]}, {"entity": "NF - kappa B", "entity_type": "GENE", "pos": [90, 102]}], "task": "NER"}
{"text": "From the autopsy findings , in 5 out of the remaining 23 expired patients , Legionella pneumonia seemed to be successfully treated , but other disease or other bacterial pneumonia put an end to the patients .", "entity": [], "task": "NER"}
{"text": "We found a prevalence of eating disorders of 5 . 9 % ( lifetime prevalence of 10 % ) , irrespective of gender and type of diabetes ; 4 . 1 % of the whole sample reported intentional insulin undertreatment or omission .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [182, 189]}], "task": "NER"}
{"text": "NER was also measured by a plasmid host cell re - activation assay using a vector containing a luciferase reporter gene .", "entity": [{"entity": "luciferase reporter gene", "entity_type": "GENE", "pos": [95, 119]}], "task": "NER"}
{"text": "Also , like TUB , it has a wider pattern of tissue expression than either TULP1 or TULP2 .", "entity": [{"entity": "TUB", "entity_type": "GENE", "pos": [12, 15]}, {"entity": "TULP1", "entity_type": "GENE", "pos": [74, 79]}, {"entity": "TULP2", "entity_type": "GENE", "pos": [83, 88]}], "task": "NER"}
{"text": "Accuracy and predictive value of ultrasound in acute rejection .", "entity": [], "task": "NER"}
{"text": "Moist healing versus wet - to - dry .", "entity": [], "task": "NER"}
{"text": "Flicker thresholds were measured from 1 to 40 Hz with a vertical - line target used for the asynchrony thresholds .", "entity": [], "task": "NER"}
{"text": "Despite the same decreases or increases in MAP , RSNA was attenuated after 15 and 30 min of propofol infusion in both groups compared with control ( P < 0 . 05 ) .", "entity": [], "task": "NER"}
{"text": "Ganglia are cysts which frequently occur in the proximity of joints .", "entity": [], "task": "NER"}
{"text": "Fractional Ca retention was measured from the 72 - h postdose WBR divided by WBR at time 0 .", "entity": [], "task": "NER"}
{"text": "Activity was reconstituted , however , by combining fractions that were enriched in the two components .", "entity": [], "task": "NER"}
{"text": "Acute morphine treatment did not increase the locomotor activity of mice withdrawn for 1 day , after withdrawal for 3 days the increase was similar to that in controls , and after 5 days the increase was clearly larger than in controls .", "entity": [], "task": "NER"}
{"text": "A significant and specific reduction in binaural peak amplitude and area of the echo - evoked middle - latency component Pa was observed .", "entity": [], "task": "NER"}
{"text": "Non - dialyzable transfer factor", "entity": [], "task": "NER"}
{"text": "Gene 1 of the murine coronavirus , MHV - A59 , encodes approximately 800 kDa of protein products within two overlapping open reading frames ( ORFs 1a and 1b ) .", "entity": [{"entity": "Gene 1 of the murine coronavirus , MHV - A59", "entity_type": "GENE", "pos": [0, 44]}], "task": "NER"}
{"text": "Stress thallium - 201 myocardial imaging was used in two angina - free patients with severe congestive heart failure to identify clinically silent areas of ischemic myocardium and to distinguish between scar and reversibly ischemic myocardium as a cause for akinesia of left ventricular wall segments .", "entity": [], "task": "NER"}
{"text": "To understand this dramatic effect , we examined the localization of SR proteins and found that SC35 was shifted to the cytoplasm in sky1Delta yeast , although this phenomenon was not obvious with ASF / SF2 , indicating that nuclear import of SR proteins may be differentially regulated by phosphorylation .", "entity": [{"entity": "SR proteins", "entity_type": "GENE", "pos": [69, 80]}, {"entity": "SC35", "entity_type": "GENE", "pos": [96, 100]}, {"entity": "sky1Delta", "entity_type": "GENE", "pos": [133, 142]}, {"entity": "ASF", "entity_type": "GENE", "pos": [197, 200]}, {"entity": "SF2", "entity_type": "GENE", "pos": [203, 206]}, {"entity": "SR proteins", "entity_type": "GENE", "pos": [243, 254]}], "task": "NER"}
{"text": "GH stimulated the activity of promoter fragments with 5 ' - ends between nucleotide ( nt ) - 2001 and nt - 653 by 1 . 9 - to 2 . 7 - fold .", "entity": [{"entity": "GH", "entity_type": "GENE", "pos": [0, 2]}], "task": "NER"}
{"text": "The 6 . 5 - kb genomic fragment contains the complete coding region of MyoD , distributed over three exons , plus 2 . 3 kb of 5 ' - noncoding sequence and 1 . 4 kb of 3 ' - noncoding sequence .", "entity": [{"entity": "MyoD", "entity_type": "GENE", "pos": [71, 75]}], "task": "NER"}
{"text": "These observations demonstrate that KSR is capable of uncoupling the MAP kinase activation from its target phosphorylation , and thus provide a novel mechanism for modulating the Ras - MAP kinase signaling pathway .", "entity": [{"entity": "KSR", "entity_type": "GENE", "pos": [36, 39]}, {"entity": "MAP kinase", "entity_type": "GENE", "pos": [69, 79]}, {"entity": "Ras", "entity_type": "GENE", "pos": [179, 182]}, {"entity": "MAP kinase", "entity_type": "GENE", "pos": [185, 195]}], "task": "NER"}
{"text": "Since 1985 the combination of chlorambucil ( 10 mg daily , initially for six weeks , then alternating fortnights for 12 weeks ) and interferon - alpha 2b ( Schering - Plough ; 2 x 10 ( 6 ) U / m2 three times weekly by subcutaneous injection for 18 weeks ) has been compared in a randomised trial with chlorambucil alone in previously untreated patients with stage III or IV follicular lymphoma .", "entity": [{"entity": "interferon - alpha 2b", "entity_type": "GENE", "pos": [132, 153]}], "task": "NER"}
{"text": "Correlation of alpha activity between the frontal and occipital cortex .", "entity": [], "task": "NER"}
{"text": "Nonetheless , the majority were located within three short sequences at the N terminus , middle , and C terminus that are phylogenetically conserved among all known eubacterial and chloroplast versions of this protein .", "entity": [], "task": "NER"}
{"text": "All other cysts showed a unilocular , purely cystic pattern , with homogeneous fluids , although the T2 relaxation times of four lesions overlapped those of odontogenic keratocysts .", "entity": [], "task": "NER"}
{"text": "Processing MES data requires large bit manipulations and heavy memory storage requirements .", "entity": [], "task": "NER"}
{"text": "Recombinant caspases are typically produced in Escherichia coli expression systems with the attendant problems of solubilization , re - folding and activation of the protease .", "entity": [{"entity": "Recombinant caspases", "entity_type": "GENE", "pos": [0, 20]}], "task": "NER"}
{"text": "Nuclear runoff assays show that complementation by HPV16 E7 restores the ability of the E1A mutants to stimulate early gene expression at the level of transcription .", "entity": [{"entity": "HPV16 E7", "entity_type": "GENE", "pos": [51, 59]}, {"entity": "E1A mutants", "entity_type": "GENE", "pos": [88, 99]}, {"entity": "early gene", "entity_type": "GENE", "pos": [113, 123]}], "task": "NER"}
{"text": "The effect of deferoxamine B on the blood sugar behavior in intravenous glucose loading in healthy persons", "entity": [], "task": "NER"}
{"text": "Constructs containing fragments of the upstream region of the cytotactin gene fused to a promoterless gene for chloramphenicol acetyltransferase were transiently transfected into chicken embryo fibroblasts to define functional promoter sequences .", "entity": [{"entity": "cytotactin gene", "entity_type": "GENE", "pos": [62, 77]}, {"entity": "chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [111, 144]}], "task": "NER"}
{"text": "Like the human erythrocyte P4 . 2 , mouse erythrocyte P4 . 2 contains regions strikingly homologous with the transglutaminase ( TGase ) proteins although it too most likely lacks TGase crosslinking activity .", "entity": [{"entity": "human erythrocyte P4 . 2", "entity_type": "GENE", "pos": [9, 33]}, {"entity": "mouse erythrocyte P4 . 2", "entity_type": "GENE", "pos": [36, 60]}], "task": "NER"}
{"text": "The rate for Arm III ( CAF therapy ) was 61 . 5 % ( 32 / 52 ) , a little higher than that for the other two .", "entity": [], "task": "NER"}
{"text": "The CHL 1 ( CTF 1 ) gene product of Saccharomyces cerevisiae is important for chromosome transmission and normal cell cycle progression in G2 / M .", "entity": [{"entity": "CHL 1", "entity_type": "GENE", "pos": [4, 9]}, {"entity": "CTF 1", "entity_type": "GENE", "pos": [12, 17]}], "task": "NER"}
{"text": "We have analyzed the function of these putative SL structures in RNA translation by constructing chimeric chloramphenicol acetyltransferase ( CAT ) RNAs , flanked either by both 5 ' - and 3 ' - terminal sequence domains from the RV genome or several deletion derivatives of the same sequences .", "entity": [{"entity": "chimeric chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [97, 139]}, {"entity": "( CAT ) RNAs", "entity_type": "GENE", "pos": [140, 152]}], "task": "NER"}
{"text": "Mutating this sequence eliminated complex formation and markedly reduced basal and cAMP - dependent promoter activity of transfected reporter genes .", "entity": [], "task": "NER"}
{"text": "The average cumulative UVA dose was 65 J / cm2 ; 40 patients had received more than 200 J / cm2 .", "entity": [], "task": "NER"}
{"text": "The induction of the composite H - PK / Tag and SV - PK / Tag transgenes by a carbohydrate - rich diet in the liver was similar to that of the endogenous L - PK gene .", "entity": [{"entity": "H - PK", "entity_type": "GENE", "pos": [31, 37]}, {"entity": "Tag", "entity_type": "GENE", "pos": [40, 43]}, {"entity": "SV - PK", "entity_type": "GENE", "pos": [48, 55]}, {"entity": "Tag", "entity_type": "GENE", "pos": [58, 61]}, {"entity": "endogenous L - PK gene", "entity_type": "GENE", "pos": [143, 165]}], "task": "NER"}
{"text": "For routine medical applications , no sophisticated adjustment of the CHESS pulse is needed , as reported in previous methods .", "entity": [], "task": "NER"}
{"text": "Here we report the cloning of the hemF gene , encoding the aerobic coproporphyrinogen III oxidase from Escherichia coli , by functional complementation of a Saccharomyces cerevisiae HEM13 mutant .", "entity": [{"entity": "hemF gene", "entity_type": "GENE", "pos": [34, 43]}, {"entity": "coproporphyrinogen III oxidase from Escherichia coli", "entity_type": "GENE", "pos": [67, 119]}, {"entity": "Saccharomyces cerevisiae HEM13 mutant", "entity_type": "GENE", "pos": [157, 194]}], "task": "NER"}
{"text": "Efficacy of probiotic feed additives : guidelines for the evaluation of the efficiency of microorganisms in dogs , cats , and horses ] Probiotic microorganisms are frequently in use as feed additives for farm and pet animals .", "entity": [], "task": "NER"}
{"text": "We analyzed the contribution of the three different types of UV - inducible mitogen - activated protein ( MAP ) kinases ( ERK , JNK / SAPK , and p38 ) to the activation of the murine uPA promoter by UV .", "entity": [{"entity": "mitogen - activated protein ( MAP ) kinases", "entity_type": "GENE", "pos": [76, 119]}, {"entity": "ERK", "entity_type": "GENE", "pos": [122, 125]}, {"entity": "JNK", "entity_type": "GENE", "pos": [128, 131]}, {"entity": "SAPK", "entity_type": "GENE", "pos": [134, 138]}, {"entity": "p38", "entity_type": "GENE", "pos": [145, 148]}, {"entity": "uPA", "entity_type": "GENE", "pos": [183, 186]}], "task": "NER"}
{"text": "The largest age adjusted differences between men with low and normal mood were for the AH4 ( 3 points , t = 5 . 6 , p < 0 . 0001 ) and the CAMCOG ( 2 points , t = 5 . 8 , p < 0 . 0001 ) .", "entity": [], "task": "NER"}
{"text": "Nucleotide sequencing revealed a 2076 - base pair open reading frame encoding a 692 - amino acid protein .", "entity": [], "task": "NER"}
{"text": "HrpE is similar to YscL of Yersinia spp .", "entity": [{"entity": "HrpE", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "YscL", "entity_type": "GENE", "pos": [19, 23]}], "task": "NER"}
{"text": "Mean total homocysteine ( tHcy ) was 21 . 1 + / - 9 . 5 micromol / L and median concentration was 19 micromol / L .", "entity": [], "task": "NER"}
{"text": "To facilitate the characterization of NF - E2 functions in human cells , we isolated cDNAs encoding two members of the small Maf family , MafK and MafG .", "entity": [{"entity": "NF - E2", "entity_type": "GENE", "pos": [38, 45]}, {"entity": "small Maf family", "entity_type": "GENE", "pos": [119, 135]}, {"entity": "MafK", "entity_type": "GENE", "pos": [138, 142]}, {"entity": "MafG", "entity_type": "GENE", "pos": [147, 151]}], "task": "NER"}
{"text": "The immediate 5 ' - flanking region was GC - rich with 3 SP - 1 - like and 2 AP - 2 sites identified in close proximity to the transcription start site .", "entity": [{"entity": "SP - 1 - like", "entity_type": "GENE", "pos": [57, 70]}, {"entity": "AP - 2 sites", "entity_type": "GENE", "pos": [77, 89]}], "task": "NER"}
{"text": "The ZAG1 protein from in vitro translations binds to a consensus target site that is recognized by the AG protein .", "entity": [{"entity": "ZAG1 protein", "entity_type": "GENE", "pos": [4, 16]}, {"entity": "AG protein", "entity_type": "GENE", "pos": [103, 113]}], "task": "NER"}
{"text": "Bone scintigraphy is an excellent screening test for bone lesions and Ga - 67 scintigraphy is a useful tool for detecting inflammatory lesions .", "entity": [], "task": "NER"}
{"text": "In this first - person account , the author chronicles her experience of being mentally ill and homeless in New York and New Jersey in the early 1980s .", "entity": [], "task": "NER"}
{"text": "Pharmacokinetics of skin penetration .", "entity": [], "task": "NER"}
{"text": "Dmyd clone encodes a polypeptide of 332 amino acids with 82 % identity to MyoD in the 41 amino acids of the putative helix - loop - helix region and 100 % identity in the 13 amino acids of the basic domain proposed to contain the essential recognition code for muscle - specific gene activation .", "entity": [{"entity": "Dmyd", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "MyoD", "entity_type": "GENE", "pos": [74, 78]}], "task": "NER"}
{"text": "Enterotoxin production by staphylococci isolated from foods in France .", "entity": [], "task": "NER"}
{"text": "Binding sites were mapped for each factor .", "entity": [], "task": "NER"}
{"text": "The majority of these cells were also OKT4 positive ( helper / inducer T lymphocytes ) , while the minority were OKT8 positive ( suppressor / cytotoxic T lymphocytes ) .", "entity": [{"entity": "OKT4", "entity_type": "GENE", "pos": [38, 42]}, {"entity": "OKT8", "entity_type": "GENE", "pos": [113, 117]}], "task": "NER"}
{"text": "Toxicological effects of dietary Maillard reaction products in the rat .", "entity": [], "task": "NER"}
{"text": "All relapses occurred within the first year and were confined to patients with PS II disease and four or more sites of involvement .", "entity": [], "task": "NER"}
{"text": "These patients developed severe diabetic symptoms including glucose intolerance , weight loss , impaired energy utilization , and nerve and brain disorders that were refractory to insulin .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [180, 187]}], "task": "NER"}
{"text": "Buserelin offers an effective alternative medical treatment of carcinoma of the prostate and , apart from impotence , does not have the side effects of oestrogens .", "entity": [], "task": "NER"}
{"text": "BCV mRNAs 5 and 5 - 1 appear to be used for the synthesis of the 12 . 7 - and 9 . 5 - kDa proteins , respectively , which demonstrates a pattern of expression strikingly different from that utilized by MHV .", "entity": [{"entity": "BCV mRNAs 5 and 5 - 1", "entity_type": "GENE", "pos": [0, 21]}], "task": "NER"}
{"text": "Consistent with this observation , introduction of Smad sites into a TGFbeta - insensitive LEF1 / TCF target gene confers cooperative TGFbeta and Wnt responsiveness to the promoter .", "entity": [{"entity": "Smad sites", "entity_type": "GENE", "pos": [51, 61]}, {"entity": "TGFbeta", "entity_type": "GENE", "pos": [69, 76]}, {"entity": "LEF1", "entity_type": "GENE", "pos": [91, 95]}, {"entity": "TCF", "entity_type": "GENE", "pos": [98, 101]}, {"entity": "TGFbeta", "entity_type": "GENE", "pos": [134, 141]}, {"entity": "Wnt", "entity_type": "GENE", "pos": [146, 149]}], "task": "NER"}
{"text": "Recombinant vaccinia viruses that express the bacteriophage T3 RNA polymerase ( VV - T3pol ) or the Escherichia coli lac repressor ( VV - lacI ) under control of the early - late vaccinia promoter P7 . 5 were constructed .", "entity": [{"entity": "bacteriophage T3 RNA polymerase", "entity_type": "GENE", "pos": [46, 77]}, {"entity": "VV - T3pol", "entity_type": "GENE", "pos": [80, 90]}, {"entity": "Escherichia coli lac repressor", "entity_type": "GENE", "pos": [100, 130]}, {"entity": "VV - lacI", "entity_type": "GENE", "pos": [133, 142]}, {"entity": "early - late vaccinia promoter P7 . 5", "entity_type": "GENE", "pos": [166, 203]}], "task": "NER"}
{"text": "Tritiated 1 , 24 , 25 - trihydroxyvitamin D3 was synthesized biologically and used as tracer to monitor the recovery of endogenous metabolite during isolation from serum .", "entity": [], "task": "NER"}
{"text": "In this report , we have examined whether PTP1B effects transformation induced by p210 bcr - abl .", "entity": [{"entity": "PTP1B", "entity_type": "GENE", "pos": [42, 47]}, {"entity": "p210", "entity_type": "GENE", "pos": [82, 86]}, {"entity": "bcr", "entity_type": "GENE", "pos": [87, 90]}, {"entity": "abl", "entity_type": "GENE", "pos": [93, 96]}], "task": "NER"}
{"text": "This study examines LEIBNIZ ' idea of Veterinary medicine in a biographical context .", "entity": [], "task": "NER"}
{"text": "Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation .", "entity": [{"entity": "prolactin receptor", "entity_type": "GENE", "pos": [19, 37]}, {"entity": "prolactin", "entity_type": "GENE", "pos": [42, 51]}], "task": "NER"}
{"text": "Using the conflict drinking test as a model , we studied in rats the effect of the nonselective beta - adrenoceptor blockers pindolol and cyanopindolol which bind to 5 - HT1A and 5 - HT1B receptors , and of the selective beta 1 - and beta 2 - adrenoceptor antagonists betaxolol and ICI 118 , 551 , respectively , which have a negligible affinity for 5 - HT receptors .", "entity": [{"entity": "beta - adrenoceptor", "entity_type": "GENE", "pos": [96, 115]}, {"entity": "5 - HT1A and 5 - HT1B receptors", "entity_type": "GENE", "pos": [166, 197]}, {"entity": "beta 1 - and beta 2 - adrenoceptor", "entity_type": "GENE", "pos": [221, 255]}, {"entity": "5 - HT receptors", "entity_type": "GENE", "pos": [350, 366]}], "task": "NER"}
{"text": "Rewarding properties of methylphenidate : sensitization by prior exposure to the drug and effects of dopamine D1 - and D2 - receptor antagonists .", "entity": [{"entity": "dopamine D1 - and D2 - receptor", "entity_type": "GENE", "pos": [101, 132]}], "task": "NER"}
{"text": "Recently , we have demonstrated that mouse microglial cells , the brain macrophages , express both IL - 15 and IL - 15 / IL - 2 receptors .", "entity": [{"entity": "IL - 15", "entity_type": "GENE", "pos": [99, 106]}, {"entity": "IL - 15 / IL - 2 receptors", "entity_type": "GENE", "pos": [111, 137]}], "task": "NER"}
{"text": "METHODS : Children with attention - deficit / hyperactivity disorder ( ADHD ; n = 282 ) , all subtypes , ages 6 to 12 years , were randomized to placebo ( n = 90 ) , immediate - release methylphenidate ( IR MPH ) 3 times a day ( tid ; dosed every 4 hours ; n = 97 ) , or OROS MPH once a day ( qd ; n = 95 ) in a double - blind , 28 - day trial .", "entity": [], "task": "NER"}
{"text": "Cell sloughing with proparacaine .", "entity": [], "task": "NER"}
{"text": "The possibility to use this method for common diagnostic problems is indicated .", "entity": [], "task": "NER"}
{"text": "The deduced amino acid sequence of this open reading frame is significantly homologous to the HSV 1 UL49 . 5 gene product , and as with UL49 . 5 , it contains a potential signal sequence and transmembrane domain characteristic of membrane - associated proteins .", "entity": [{"entity": "HSV 1 UL49 . 5 gene product", "entity_type": "GENE", "pos": [94, 121]}, {"entity": "UL49 . 5", "entity_type": "GENE", "pos": [136, 144]}], "task": "NER"}
{"text": "Female Wistar rats receiving alcohol ( 5 % ) in drinking water during lactation ( N = 7 ) were compared to normal controls fed ad libitum ( N = 6 ) .", "entity": [], "task": "NER"}
{"text": "Suspected pelvic endometriosis was prospectively evaluated in 31 women with T1 - and T2 - weighted conventional spin - echo ( CSE ) magnetic resonance imaging alone and in combination with T1 - weighted fat - suppressed ( T1FS ) and gadolinium - enhanced T1FS ( Gd - T1FS ) spin - echo techniques .", "entity": [], "task": "NER"}
{"text": "Eph receptors and their membrane - associated ephrin ligands regulate cell - cell interactions during development .", "entity": [{"entity": "Eph receptors", "entity_type": "GENE", "pos": [0, 13]}, {"entity": "ephrin ligands", "entity_type": "GENE", "pos": [46, 60]}], "task": "NER"}
{"text": "A group of factors known as activating transcription factors ( ATF ) have been found to bind to the latter and related sequences found upstream of early adenovirus promoters induced by E1A , and these factors are highly homologous to the CREB protein .", "entity": [{"entity": "activating transcription factors", "entity_type": "GENE", "pos": [28, 60]}, {"entity": "ATF", "entity_type": "GENE", "pos": [63, 66]}, {"entity": "E1A", "entity_type": "GENE", "pos": [185, 188]}, {"entity": "CREB protein", "entity_type": "GENE", "pos": [238, 250]}], "task": "NER"}
{"text": "Vk8 / Jk2 and Vk1 / Jk5 rearrangements encoded the respective L chain V - regions .", "entity": [{"entity": "Vk8", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "Jk2", "entity_type": "GENE", "pos": [6, 9]}, {"entity": "Vk1", "entity_type": "GENE", "pos": [14, 17]}, {"entity": "Jk5", "entity_type": "GENE", "pos": [20, 23]}, {"entity": "L chain V - regions", "entity_type": "GENE", "pos": [62, 81]}], "task": "NER"}
{"text": "An analysis of the c - kit 5 ' flanking region using the bacterial chloramphenicol acetyltransferase gene ( CAT assay ) in human erythroleukemia HEL cells , which express the endogenous c - kit mRNA at high levels , showed that a region from - 180 to - 22 is important for the expression of the c - kit gene .", "entity": [{"entity": "c - kit 5 ' flanking region", "entity_type": "GENE", "pos": [19, 46]}, {"entity": "bacterial chloramphenicol acetyltransferase gene", "entity_type": "GENE", "pos": [57, 105]}, {"entity": "CAT", "entity_type": "GENE", "pos": [108, 111]}, {"entity": "c - kit mRNA", "entity_type": "GENE", "pos": [186, 198]}, {"entity": "c - kit gene", "entity_type": "GENE", "pos": [295, 307]}], "task": "NER"}
{"text": "The quantitative analysis of 1 - alpha - acetylmethadol and its principal metabolites in biological specimens by gas chromatography - chemical ionization - multiple ion monitoring mass spectrometry .", "entity": [], "task": "NER"}
{"text": "Following immunization of transgenic mice , hybrid molecules were isolated from B cell DNA which contained the transgene recombined with the endogenous IgH locus .", "entity": [{"entity": "endogenous IgH locus", "entity_type": "GENE", "pos": [141, 161]}], "task": "NER"}
{"text": "( LH P < 0 . 05 , LH / FSH P < 0 . 01 ) .", "entity": [{"entity": "LH", "entity_type": "GENE", "pos": [2, 4]}, {"entity": "LH", "entity_type": "GENE", "pos": [18, 20]}, {"entity": "FSH", "entity_type": "GENE", "pos": [23, 26]}], "task": "NER"}
{"text": "Here we show that expression of KRAB domain suppresses in vivo the activating function of various defined activating transcription factors , and we demonstrate that the KRAB domain specifically silences the activity of promoters whose initiation is dependent on the presence of a TATA box .", "entity": [{"entity": "KRAB domain", "entity_type": "GENE", "pos": [32, 43]}, {"entity": "activating transcription factors", "entity_type": "GENE", "pos": [106, 138]}, {"entity": "KRAB domain", "entity_type": "GENE", "pos": [169, 180]}], "task": "NER"}
{"text": "In the renal cortex , spleen , distal colon , ileum , gallbladder , and stomach body , regional O2 delivery was significantly decreased with hemodilution to 20 % in both groups .", "entity": [], "task": "NER"}
{"text": "None of the 19 women with probable RA and 100 of the 116 women with definite RA met the 1987 criteria .", "entity": [], "task": "NER"}
{"text": "In response to the need for better quantitative estimates of the regional distribution of the active bone marrow organ in infants and children , a method using various anatomical data has been developed .", "entity": [], "task": "NER"}
{"text": "Thus the Hi - RARE represents a new type of RA response element with a role in the modulation of the expression of MHC class 1 family genes .", "entity": [{"entity": "MHC class 1", "entity_type": "GENE", "pos": [115, 126]}], "task": "NER"}
{"text": "RESULTS : Considering an inulin clearance of less than 80 ml / min / 1 . 73 m2 , the cut - off value for serum creatinine was 11 . 5 mumol / liter for men and 90 mumol / liter for women .", "entity": [], "task": "NER"}
{"text": "Our results strongly suggest that activation of the beta origin by a distant replication enhancer element requires a small target sequence essential for initiator protein - mediated DNA looping .", "entity": [], "task": "NER"}
{"text": "Three experiments using 20 microM 2 - ( hydroxyamino ) - 1 - methyl - 6 - phenylimidazo [ 4 , 5 - b ] pyridine ( N - OH - PhIP ) were performed to induce mutations in the dihydrofolate reductase ( DHFR ) gene of a hemizygous Chinese hamster ovary ( CHO ) cell line ( UA21 ) .", "entity": [{"entity": "dihydrofolate reductase", "entity_type": "GENE", "pos": [171, 194]}, {"entity": "DHFR", "entity_type": "GENE", "pos": [197, 201]}], "task": "NER"}
{"text": "The UL3 ORF of 204 amino acids shows significant homology to UL3 ( nuclear phosphoprotein ) of HSV - 1 ( 62 % ) and PRV ( 53 % ) .", "entity": [{"entity": "UL3 ORF", "entity_type": "GENE", "pos": [4, 11]}, {"entity": "UL3", "entity_type": "GENE", "pos": [61, 64]}], "task": "NER"}
{"text": "Immunogenicity tested in experiments on guinea pigs and rabbits was not reduced and corresponded to that of the reference STI - 1 vaccine .", "entity": [], "task": "NER"}
{"text": "In addition , we show that expression of antisense mRNA for p130CAS resulted in reversion of the transformed phenotype of all these cell lines .", "entity": [{"entity": "p130CAS", "entity_type": "GENE", "pos": [60, 67]}], "task": "NER"}
{"text": "One hundred cDNA clones were sequenced and 8 RTKs were identified , as well as 12 non - RTKs and 2 serine / threonine kinases .", "entity": [{"entity": "RTKs", "entity_type": "GENE", "pos": [45, 49]}, {"entity": "RTKs", "entity_type": "GENE", "pos": [88, 92]}, {"entity": "serine / threonine kinases", "entity_type": "GENE", "pos": [99, 125]}], "task": "NER"}
{"text": "Supportive therapy with xenogenous peptides in patients with metastatic breast cancer undergoing aggressive chemotherapy ( modified AC - protocol ) : a prospective , randomized double - blind study", "entity": [], "task": "NER"}
{"text": "The inactive X allele , however , is hypermethylated in leukocytes , presumably reflecting early X inactivation events that become important for gene dosage in expressing lineages .", "entity": [], "task": "NER"}
{"text": "Development of neural control of alimentary motor function in the vertebrates .", "entity": [], "task": "NER"}
{"text": "Studies on nitrogen - containing heterocyclic compounds .", "entity": [], "task": "NER"}
{"text": "Cell rounding was abrogated by expression of either kinase - dead forms of US3 PK or a mutant protein lacking the acidic cluster in the kinase regulatory domain .", "entity": [{"entity": "US3 PK", "entity_type": "GENE", "pos": [75, 81]}], "task": "NER"}
{"text": "The psychosocial features of people using self - ignition as a method of suicide are consistent with those of suicide in general .", "entity": [], "task": "NER"}
{"text": "The genes expressed during the embryonic ( zeta ) or fetal and adult stage ( alpha 2 and alpha 1 ) can be modified by point mutations which affect either the processing - translation of mRNA or make the polypeptide chains extremely unstable .", "entity": [{"entity": "zeta", "entity_type": "GENE", "pos": [43, 47]}, {"entity": "alpha 2", "entity_type": "GENE", "pos": [77, 84]}, {"entity": "alpha 1", "entity_type": "GENE", "pos": [89, 96]}], "task": "NER"}
{"text": "Acoustic - property measurements of the oxide superconductor BaPb1 - xBixO3 by the sphere - resonance method .", "entity": [], "task": "NER"}
{"text": "The fusion of AML1 to MDS1 is in frame , and adds 127 codons to the interrupted AML1 .", "entity": [{"entity": "AML1", "entity_type": "GENE", "pos": [14, 18]}, {"entity": "MDS1", "entity_type": "GENE", "pos": [22, 26]}, {"entity": "AML1", "entity_type": "GENE", "pos": [80, 84]}], "task": "NER"}
{"text": "The ends of the barrel are capped by short helices .", "entity": [], "task": "NER"}
{"text": "Rabbit KCC1 ( rbKCC1 ) and rat KCC1 ( rtKCC1 ) were cloned by screening rabbit kidney and rat brain cDNA libraries using homologous cDNA probes .", "entity": [{"entity": "Rabbit KCC1", "entity_type": "GENE", "pos": [0, 11]}, {"entity": "rbKCC1", "entity_type": "GENE", "pos": [14, 20]}, {"entity": "rat KCC1", "entity_type": "GENE", "pos": [27, 35]}, {"entity": "rtKCC1", "entity_type": "GENE", "pos": [38, 44]}], "task": "NER"}
{"text": "Taken together , these findings demonstrate that ZNF76 and ZNF143 are two members of a same family of transactivator proteins .", "entity": [{"entity": "ZNF76", "entity_type": "GENE", "pos": [49, 54]}, {"entity": "ZNF143", "entity_type": "GENE", "pos": [59, 65]}], "task": "NER"}
{"text": "This model system exploits the polyomavirus late transcription termination and polyadenylation signals , which are sufficiently weak to allow the production of many multigenome - length primary transcripts with repeating introns , exons , and poly ( A ) sites .", "entity": [], "task": "NER"}
{"text": "The disorders are accompanied by consistent , but similarly reversible , electroencephalographic changes .", "entity": [], "task": "NER"}
{"text": "Electronic structure and optical properties of the B12O2 crystal .", "entity": [], "task": "NER"}
{"text": "A model for oligomerization - dependent subunit folding .", "entity": [], "task": "NER"}
{"text": "The reporter gene with two copies of the wild - type Repeat 2 + 3 sequence was transcribed actively in sterol - deprived cells and was repressed by more than 80 % when sterols were present .", "entity": [], "task": "NER"}
{"text": "Basic helix - loop - helix proteins can act at the E - box within the serum response element of the c - fos promoter to influence hormone - induced promoter activation in Sertoli cells .", "entity": [{"entity": "Basic helix - loop - helix proteins", "entity_type": "GENE", "pos": [0, 35]}, {"entity": "c - fos promoter", "entity_type": "GENE", "pos": [100, 116]}], "task": "NER"}
{"text": "Preventive health counseling tailored to the needs of this group may be most beneficial .", "entity": [], "task": "NER"}
{"text": "Western blot analyses reveals that cJun and the C / EBP family member C / EBP - beta are physiologically relevant transcription factors whose expression corresponds with mda - 7 mRNA expression .", "entity": [{"entity": "cJun", "entity_type": "GENE", "pos": [35, 39]}, {"entity": "C / EBP family member", "entity_type": "GENE", "pos": [48, 69]}, {"entity": "C / EBP - beta", "entity_type": "GENE", "pos": [70, 84]}, {"entity": "mda - 7 mRNA", "entity_type": "GENE", "pos": [170, 182]}], "task": "NER"}
{"text": "Recent developments in the study of growth factors : GRF and somatomedins .", "entity": [{"entity": "GRF", "entity_type": "GENE", "pos": [53, 56]}, {"entity": "somatomedins", "entity_type": "GENE", "pos": [61, 73]}], "task": "NER"}
{"text": "Phenotypic screening of mutations in Pmr1 , the yeast secretory pathway Ca2 + / Mn2 + - ATPase , reveals residues critical for ion selectivity and transport .", "entity": [{"entity": "Pmr1", "entity_type": "GENE", "pos": [37, 41]}, {"entity": "yeast secretory pathway Ca2 + / Mn2 + - ATPase", "entity_type": "GENE", "pos": [48, 94]}], "task": "NER"}
{"text": "IV .", "entity": [], "task": "NER"}
{"text": "Routine and default retrieval home visits were given to ensure maximal drug compliance .", "entity": [], "task": "NER"}
{"text": "This review chronicles the characteristics of deliberate and accidental mass poisonings that occurred in World Wars I and II , in Bhopal , and in other historical cases up to and including modern wars .", "entity": [], "task": "NER"}
{"text": "Thus , an unmodified threonine at position 169 in Cdc28 is important for interaction with G1 cyclins .", "entity": [{"entity": "Cdc28", "entity_type": "GENE", "pos": [50, 55]}, {"entity": "G1 cyclins", "entity_type": "GENE", "pos": [90, 100]}], "task": "NER"}
{"text": "These alterations occurred at both the mRNA and protein levels but did not significantly affect the subcellular distribution of any of the four isoforms .", "entity": [], "task": "NER"}
{"text": "Periarteritis nodosa with ruptures of the renal vessels and the persistence of the hepatitis B and C viruses in the blood", "entity": [], "task": "NER"}
{"text": "SETTING : Participants in the Physicians ' Health Study , a randomized trial of aspirin and beta - carotene among U . S . male physicians .", "entity": [], "task": "NER"}
{"text": "Treatment of chronic hepatitis B with interferon : experience in western countries .", "entity": [{"entity": "interferon", "entity_type": "GENE", "pos": [38, 48]}], "task": "NER"}
{"text": "Similar to what was observed for P . putida , a psrA null mutant of P . aeruginosa also showed a 90 % reduction in rpoS promoter activity ; both mutants could be complemented for rpoS promoter activity when the psrA gene was provided in trans . psrA mutants of both Pseudomonas species lost the ability to induce rpoS expression at stationary phase , but they retained the ability to produce quorum - sensing autoinducer molecules .", "entity": [{"entity": "psrA", "entity_type": "GENE", "pos": [48, 52]}, {"entity": "rpoS promoter", "entity_type": "GENE", "pos": [115, 128]}, {"entity": "rpoS promoter", "entity_type": "GENE", "pos": [179, 192]}, {"entity": "psrA gene", "entity_type": "GENE", "pos": [211, 220]}, {"entity": "psrA mutants", "entity_type": "GENE", "pos": [245, 257]}, {"entity": "rpoS", "entity_type": "GENE", "pos": [313, 317]}], "task": "NER"}
{"text": "The increments in median plasma secretin concentration were 1 . 6 , 3 . 0 , and 6 . 4 pmol x 1 ( - 1 ) after secretin , 125 , 250 and 500 fmol x kg - 1 , and the corresponding 15 - min bicarbonate output 283 , 442 , and 1435 micromol , respectively .", "entity": [{"entity": "plasma secretin", "entity_type": "GENE", "pos": [25, 40]}, {"entity": "secretin", "entity_type": "GENE", "pos": [109, 117]}], "task": "NER"}
{"text": "The composition of renal stones analysed by infrared spectroscopy .", "entity": [], "task": "NER"}
{"text": "Programmed peritoneal lavage in suppurative complications of perforated ulcer of the stomach", "entity": [], "task": "NER"}
{"text": "Vibrio cholerae iron transport : haem transport genes are linked to one of two sets of tonB , exbB , exbD genes .", "entity": [{"entity": "tonB", "entity_type": "GENE", "pos": [87, 91]}, {"entity": "exbB", "entity_type": "GENE", "pos": [94, 98]}, {"entity": "exbD genes", "entity_type": "GENE", "pos": [101, 111]}], "task": "NER"}
{"text": "Zonography in urology ( author ' s transl )", "entity": [], "task": "NER"}
{"text": "Phenazopyridine - induced hemolytic anemia in a patient with G6PD deficiency .", "entity": [{"entity": "G6PD", "entity_type": "GENE", "pos": [61, 65]}], "task": "NER"}
{"text": "The novel gene spans 16 . 7 kb of genomic sequence and it is formed of 11 exons and 10 intervening introns .", "entity": [], "task": "NER"}
{"text": "Overexpression of a HIF - 1alpha construct with deletions of the basic domain and carboxy terminus blocked reporter gene activation by endogenous HIF - 1 in hypoxic cells .", "entity": [{"entity": "HIF - 1alpha", "entity_type": "GENE", "pos": [20, 32]}, {"entity": "HIF - 1", "entity_type": "GENE", "pos": [146, 153]}], "task": "NER"}
{"text": "A preformed SREBP - 1a : [ 32P ] DNA complex bound specifically to membrane - immobilized GST - CBP fusion proteins that contained amino - terminal portions of CBP .", "entity": [{"entity": "SREBP - 1a : [ 32P ] DNA complex", "entity_type": "GENE", "pos": [12, 44]}, {"entity": "GST", "entity_type": "GENE", "pos": [90, 93]}, {"entity": "CBP", "entity_type": "GENE", "pos": [96, 99]}, {"entity": "CBP", "entity_type": "GENE", "pos": [160, 163]}], "task": "NER"}
{"text": "Extracellular protein kinase A as a cancer biomarker : its expression by tumor cells and reversal by a myristate - lacking Calpha and RIIbeta subunit overexpression .", "entity": [{"entity": "Extracellular protein kinase A", "entity_type": "GENE", "pos": [0, 30]}], "task": "NER"}
{"text": "By incorporating a stent with posts that pivot about their base , such that a 10 % expansion at the commissures is realized , we were able to reduce the compressive commissural stressing from 250 to 150 kPa .", "entity": [], "task": "NER"}
{"text": "With rats fed on the Zn - sufficient diet , NaFe3 + EDTA and Na2EDTA similarly increased the absorption , urinary excretion and retention of Zn but to a lesser extent .", "entity": [], "task": "NER"}
{"text": "The requirement for an essential interaction between NPH I and H4L provides an explanation for the observed restriction of transcription termination to early viral genes .", "entity": [{"entity": "NPH I", "entity_type": "GENE", "pos": [53, 58]}, {"entity": "H4L", "entity_type": "GENE", "pos": [63, 66]}], "task": "NER"}
{"text": "Other clinicopathological features have no definite influence in survival expectancy .", "entity": [], "task": "NER"}
{"text": "Births , marriages , divorces , and deaths for July 1997 .", "entity": [], "task": "NER"}
{"text": "One day postoperatively , the mononuclear leukocyte beta 2 - receptor density decreased maximally by 45 + / - 11 % in the enflurane patients , and by 53 + / - 6 % in the neurolept patients .", "entity": [{"entity": "beta 2 - receptor", "entity_type": "GENE", "pos": [52, 69]}], "task": "NER"}
{"text": "A direct statistically reliable correction of decrease of the enzymes with the initial state of the patients has been established in an analysis of 25 patients aged from 18 to 60 years in prosthesis of + the mitral valve ( n - 9 ) and closed mitral commissurotomy ( n - 16 ) .", "entity": [], "task": "NER"}
{"text": "However , it was observed that storage time affected significantly the biochemical changes occurring in the constituents of carrots exposed to gamma - irradiation .", "entity": [], "task": "NER"}
{"text": "Partial proteolysis of cell surface - iodinated B - G molecules generates extremely similar patterns of spots , both within and between haplotypes .", "entity": [{"entity": "B - G molecules", "entity_type": "GENE", "pos": [48, 63]}], "task": "NER"}
{"text": "Here we demonstrate the ability of oligonucleotides containing the C4T sequence to confer heat shock inducibility on the reporter gene and show that the presence of two such elements produces more than additive effects on induction .", "entity": [], "task": "NER"}
{"text": "In the other two groups ( NAAR and PLA ) , no variation in this serum protease was observed .", "entity": [], "task": "NER"}
{"text": "The KEMAR measurements show that the two models give an improvement of the signal - to - noise ratio of approximately 7 . 5 dB in a diffuse sound field .", "entity": [], "task": "NER"}
{"text": "Providing appropriate care to both sexes .", "entity": [], "task": "NER"}
{"text": "An X - linked zinc finger gene mapping to Xq21 . 1 - q21 . 3 closely related to ZFX and ZFY : possible origins from a common ancestral gene .", "entity": [{"entity": "zinc finger gene", "entity_type": "GENE", "pos": [14, 30]}, {"entity": "ZFX", "entity_type": "GENE", "pos": [80, 83]}, {"entity": "ZFY", "entity_type": "GENE", "pos": [88, 91]}], "task": "NER"}
{"text": "Mutations that extend the specificity of the endonuclease activity of lambda terminase .", "entity": [{"entity": "lambda terminase", "entity_type": "GENE", "pos": [70, 86]}], "task": "NER"}
{"text": "Promoter activity was assayed by transient transfection of luciferase reporter constructs containing nested deletions of the upstream sequence in the human RPE cell lines ARPE19 and D407 , as well as in the SK - Mel - 28 and HeLa cell lines .", "entity": [{"entity": "luciferase reporter constructs", "entity_type": "GENE", "pos": [59, 89]}], "task": "NER"}
{"text": "These results suggest an essential role of the binding of HNF - 4 and / or HNF - 4 - related nuclear factors to the 6 beta A - A site on the basal transcriptional activation of the CYP3A2 gene in liver cells .", "entity": [{"entity": "HNF - 4", "entity_type": "GENE", "pos": [58, 65]}, {"entity": "HNF - 4 - related nuclear factors", "entity_type": "GENE", "pos": [75, 108]}, {"entity": "CYP3A2 gene", "entity_type": "GENE", "pos": [181, 192]}], "task": "NER"}
{"text": "A vascular component to impotence was shown to be common in those with neurological impairment , and may alter management .", "entity": [], "task": "NER"}
{"text": "Bandwidth of auditory units in the chick forebrain ( field L / Hv complex ) was measured with isointensity tone stimuli .", "entity": [], "task": "NER"}
{"text": "Two cases of Paraquat poisoning of anticonservative origin are described .", "entity": [], "task": "NER"}
{"text": "The promoter of this methyltransferase gene lacks an identifiable TATA box but is characterized by a CpG island which begins approximately 723 nucleotides upstream of the major transcriptional start site and extends through exon 1 and into the first intron .", "entity": [], "task": "NER"}
{"text": "It also describes the preliminary results of a Phase II trial going on at the Central Institute for Tumors in Zagreb , using a combination of cis - DDP , 5 - fluorouracil and vincristine .", "entity": [], "task": "NER"}
{"text": "Three patients with Mirizzi type II syndrome and two patients with Mirizzi type I syndrome were treated laparoscopically .", "entity": [], "task": "NER"}
{"text": "The pregnancies were terminated at 19 and 12 weeks of gestation , respectively .", "entity": [], "task": "NER"}
{"text": "The treatment with glucocorticoids and immunosuppressants resulted in a more noticeable decrease in the levels of T3 and E - RCF .", "entity": [{"entity": "E - RCF", "entity_type": "GENE", "pos": [121, 128]}], "task": "NER"}
{"text": "It is concluded that the new class of competitive NMDA receptor antagonists , exemplified by CGP 37849 , is the most promising candidate for clinical trials in anxiety disorders .", "entity": [{"entity": "NMDA receptor", "entity_type": "GENE", "pos": [50, 63]}], "task": "NER"}
{"text": "Rapid , sensitive gas chromatographic analysis of 8 - methoxypsoralen in human plasma .", "entity": [], "task": "NER"}
{"text": "RESULTS : Sixty - one percent of the patients had damage within 7 years of onset ( mean 3 . 8 yrs ) .", "entity": [], "task": "NER"}
{"text": "In the fungus Neurospora crassa , nit - 2 , the major nitrogen regulatory gene , activates the expression of unlinked structural genes that specify nitrogen - catabolic enzymes during conditions of nitrogen limitation .", "entity": [{"entity": "nit - 2", "entity_type": "GENE", "pos": [34, 41]}], "task": "NER"}
{"text": "We concluded that HFV can achieve values of CO2 elimination close to the estimated metabolic CO2 production in normal unintubated subjects over short periods of time .", "entity": [], "task": "NER"}
{"text": "Tetrazepam : a benzodiazepine which dissociates sedation from other benzodiazepine activities .", "entity": [], "task": "NER"}
{"text": "Transcripts appear to be initiated from an upstream promoter , P1 , located in front of the tRNA ( met1 ) gene and from three internal promoters : P2 is located immediately in front of the tRNA ( met2 ) gene ; PL10 is near the beginning of the L1 - L10 intergenic space , and PL12 is at the end of the L10 gene sequence .", "entity": [{"entity": "tRNA ( met1 ) gene", "entity_type": "GENE", "pos": [92, 110]}, {"entity": "tRNA ( met2 ) gene", "entity_type": "GENE", "pos": [189, 207]}, {"entity": "L1", "entity_type": "GENE", "pos": [211, 213]}, {"entity": "L10", "entity_type": "GENE", "pos": [249, 252]}, {"entity": "L10 gene sequence", "entity_type": "GENE", "pos": [302, 319]}], "task": "NER"}
{"text": "Nearly 1 . 5 million American men age 65 and older have osteoporosis , and another 3 . 5 million are at risk .", "entity": [], "task": "NER"}
{"text": "We have characterized 21 mutations in the type VII collagen gene ( COL7A1 ) encoding the anchoring fibrils , 18 of which were not previously reported , in patients from 15 unrelated families with recessive dystrophic epidermolysis bullosa ( RDEB ) .", "entity": [{"entity": "type VII collagen gene", "entity_type": "GENE", "pos": [42, 64]}, {"entity": "COL7A1", "entity_type": "GENE", "pos": [67, 73]}], "task": "NER"}
{"text": "A case of heterotopic gastric mucosa ( pyloric gland ) in the wall of the gallbladder was reported .", "entity": [], "task": "NER"}
{"text": "Ribosome association of GCN2 protein kinase , a translational activator of the GCN4 gene of Saccharomyces cerevisiae .", "entity": [{"entity": "GCN2 protein kinase", "entity_type": "GENE", "pos": [24, 43]}, {"entity": "GCN4 gene", "entity_type": "GENE", "pos": [79, 88]}], "task": "NER"}
{"text": "We further examined the interaction of JAK2 with the GHR cytoplasmic domain by two lines of investigation .", "entity": [{"entity": "JAK2", "entity_type": "GENE", "pos": [39, 43]}, {"entity": "GHR", "entity_type": "GENE", "pos": [53, 56]}], "task": "NER"}
{"text": "These segments may represent pseudogenes .", "entity": [], "task": "NER"}
{"text": "Corresponding oligonucleotides were used to screen a rat liver cDNA library constructed in the plasmid cloning vector , pcDV .", "entity": [], "task": "NER"}
{"text": "A .", "entity": [], "task": "NER"}
{"text": "Extracellular regulated kinases ( ERK ) 1 and ERK2 are authentic substrates for the dual - specificity protein - tyrosine phosphatase VHR .", "entity": [{"entity": "Extracellular regulated kinases ( ERK ) 1", "entity_type": "GENE", "pos": [0, 41]}, {"entity": "ERK2", "entity_type": "GENE", "pos": [46, 50]}, {"entity": "dual - specificity protein - tyrosine phosphatase VHR", "entity_type": "GENE", "pos": [84, 137]}], "task": "NER"}
{"text": "The model therefore predicts that 1 ) on - line calculation of airway dead space and end - expired lung volume can be made by the addition of an oxygen sine - wave perturbation component to the mean FIO2 ; and ( 2 ) QS / QT can be measured from the resultant oxygen perturbation sine - wave amplitudes in the expired gas and in arterial and mixed - venous blood and is independent of the mean blood oxygen partial pressure and oxyhemoglobin saturation values .", "entity": [{"entity": "oxyhemoglobin", "entity_type": "GENE", "pos": [427, 440]}], "task": "NER"}
{"text": "An anoerxiant , mazindol suppresses food intake by 1 ) stimulating beta - adrenergic receptors , 2 ) inhibiting the feeding center and , 3 ) stimulating the satiety center in the hypothalamus .", "entity": [{"entity": "beta - adrenergic receptors", "entity_type": "GENE", "pos": [67, 94]}], "task": "NER"}
{"text": "When patients were admitted within one week of the onset of dark urine , 45 % were found to be shedding HAV , whereas only 11 % of specimens obtained from patients admitted during the second week contained virus .", "entity": [], "task": "NER"}
{"text": "Positive effects of radioactive therapy in Guarapari", "entity": [], "task": "NER"}
{"text": "Nevertheless , lower doses which alone were lacking in activity ( 100 - 250 mg / kg B1 and B6 , 1 - 2 . 5 mg / kg B12 p . o . ) dose - dependently potentiated the antinociceptive of diclofenac .", "entity": [], "task": "NER"}
{"text": "Escherichia coli strains carrying recA730 ( or other recA * alleles ) exhibit dramatic increases in SOS - dependent spontaneous mutator activity .", "entity": [{"entity": "recA730", "entity_type": "GENE", "pos": [34, 41]}, {"entity": "recA * alleles", "entity_type": "GENE", "pos": [53, 67]}], "task": "NER"}
{"text": "On the contrary i . v . administration of calcitonin increased intrapyloric pressure via vagal nerves in atropinized or gallaminized animals .", "entity": [{"entity": "calcitonin", "entity_type": "GENE", "pos": [42, 52]}], "task": "NER"}
{"text": "An hcr1 null mutant was viable , but showed slight reduction of growth when compared with the wild - type strain .", "entity": [{"entity": "hcr1", "entity_type": "GENE", "pos": [3, 7]}], "task": "NER"}
{"text": "Overall , free - chlorine treatments ( 0 . 3 or 1 . 0 mg / L ) showed significantly lower heterotrophic plate numbers than those without free chlorine .", "entity": [], "task": "NER"}
{"text": "This evaluation examines several analytical and cost parameters for five representative assays : IgG , IgA , IgM , phenytoin , and phenobarbital .", "entity": [{"entity": "IgG", "entity_type": "GENE", "pos": [97, 100]}, {"entity": "IgA", "entity_type": "GENE", "pos": [103, 106]}, {"entity": "IgM", "entity_type": "GENE", "pos": [109, 112]}], "task": "NER"}
{"text": "We have previously identified LIT1 , a paternally expressed antisense RNA within the KvLQT1 locus through a positional screening approach using human monochromosomal hybrids .", "entity": [{"entity": "LIT1", "entity_type": "GENE", "pos": [30, 34]}, {"entity": "KvLQT1 locus", "entity_type": "GENE", "pos": [85, 97]}], "task": "NER"}
{"text": "Here RFX / X2BP / DNA complexes were formed on all class II isotypes regardless of the ability of the X box region to bind either factor individually .", "entity": [{"entity": "RFX", "entity_type": "GENE", "pos": [5, 8]}, {"entity": "X2BP", "entity_type": "GENE", "pos": [11, 15]}], "task": "NER"}
{"text": "Developmental slot blots demonstrate that mRNAs corresponding to the three LHM cDNAs are transcribed from prophase of meiosis I to the uninucleate microspore stage , while Northern analysis reveals these tapetally expressed cDNAs to correspond with transcripts of some 500 bp .", "entity": [{"entity": "LHM cDNAs", "entity_type": "GENE", "pos": [75, 84]}], "task": "NER"}
{"text": "The curse of the Pharaohs .", "entity": [], "task": "NER"}
{"text": "The women in the intermediate calcium group had approximately the same mean BMD values as those in the low calcium group .", "entity": [], "task": "NER"}
{"text": "The enigma of aging bone loss .", "entity": [], "task": "NER"}
{"text": "RESULTS : After lavage , a rapid decrease in arterial pH and PaO2 , and an increase in PaCO2 and PIP were observed in all animals .", "entity": [], "task": "NER"}
{"text": "In both cell types , insulin led to a dose - dependent increase in the association of tyrosine phosphorylated IRS - 1 with the SH2 domain of the p85 regulatory subunit of PI - 3 kinase , and also increased the amount of PI kinase activity detected in anti - IRS - 1 immunoprecipitates .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [21, 28]}, {"entity": "tyrosine phosphorylated IRS - 1", "entity_type": "GENE", "pos": [86, 117]}, {"entity": "SH2 domain", "entity_type": "GENE", "pos": [127, 137]}, {"entity": "p85 regulatory subunit", "entity_type": "GENE", "pos": [145, 167]}, {"entity": "PI - 3 kinase", "entity_type": "GENE", "pos": [171, 184]}, {"entity": "PI kinase", "entity_type": "GENE", "pos": [220, 229]}, {"entity": "anti - IRS - 1", "entity_type": "GENE", "pos": [251, 265]}], "task": "NER"}
{"text": "Twelve ( 92 % ) showed cognitive dysfunction including impairments in memory , attention , and affective disturbances ( anxiety , depression , irritability , and poor frustration tolerance ) .", "entity": [], "task": "NER"}
{"text": "These effects were antagonized by prior administration of 1 - ( 2 - methoxyphenyl ) - 4 - [ - ( 2 - phthalimido ) butyl ] piperazine ) ( 0 . 5 mg / kg , i . p . ) .", "entity": [], "task": "NER"}
{"text": "Transcription initiation from this region was also detected in vivo , when the cloned rRNA gene cluster was present on a multi - copy plasmid .", "entity": [], "task": "NER"}
{"text": "The human parvalbumin mRNA contains the putative polyadenylation signal AATAAA 13 nucleotides upstream from the polyadenylation site .", "entity": [{"entity": "human parvalbumin mRNA", "entity_type": "GENE", "pos": [4, 26]}], "task": "NER"}
{"text": "The effects of dopamine and of dopamine D2 receptor blocker haloperidol on the activity of carotid chemoreceptors were studied in 24 anesthetized , paralyzed and artificially ventilated newborn kittens aged 0 - 17 days .", "entity": [{"entity": "dopamine D2 receptor", "entity_type": "GENE", "pos": [31, 51]}], "task": "NER"}
{"text": "DNMT2 binds AdoHcy in the same conformation as confirmed m ( 5 ) C MTases and , while DNMT2 shares all sequence and structural features with m ( 5 ) C MTases , it has failed to demonstrate detectable transmethylase activity .", "entity": [{"entity": "DNMT2", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "m ( 5 ) C MTases", "entity_type": "GENE", "pos": [57, 73]}, {"entity": "DNMT2", "entity_type": "GENE", "pos": [86, 91]}, {"entity": "m ( 5 ) C MTases", "entity_type": "GENE", "pos": [141, 157]}], "task": "NER"}
{"text": "Serum amyloid A ( SAA ) is a plasma protein which has been associated with several diseases , including amyloidosis , arthritis , and atherosclerosis , and its abnormal expression , particularly in nonhepatic cells , is implicated in the pathogenesis of these diseases .", "entity": [{"entity": "Serum amyloid A", "entity_type": "GENE", "pos": [0, 15]}, {"entity": "SAA", "entity_type": "GENE", "pos": [18, 21]}], "task": "NER"}
{"text": "The standardized incidence in Europeans has risen significantly to 4 . 7 / 10 ( 5 ) / year from 3 . 4 / 10 ( 5 ) / year in the 1970s ( chi 2 = 8 . 1 , p less than 0 . 005 ) .", "entity": [], "task": "NER"}
{"text": "Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43 - kb segment including the RING1 , HKE6 , and HKE4 genes .", "entity": [{"entity": "human MHC", "entity_type": "GENE", "pos": [43, 52]}, {"entity": "RING1", "entity_type": "GENE", "pos": [116, 121]}, {"entity": "HKE6", "entity_type": "GENE", "pos": [124, 128]}, {"entity": "HKE4 genes", "entity_type": "GENE", "pos": [135, 145]}], "task": "NER"}
{"text": "The cells arrest in the G1 phase of the cell cycle and grow a projection towards one another forming a shmoo projection .", "entity": [], "task": "NER"}
{"text": "Multiple aortic thrombi associated with protein C and S deficiency .", "entity": [{"entity": "protein C", "entity_type": "GENE", "pos": [40, 49]}, {"entity": "S", "entity_type": "GENE", "pos": [54, 55]}], "task": "NER"}
{"text": "However , the optimum compressive strength reached values up to 40 % higher than CC - free samples .", "entity": [], "task": "NER"}
{"text": "POPULATION AND METHODS : 105 patients were followed prospectively ( male : 87 % ; age : 56 + / - 10 ) ; clinical evaluation was performed in the 1st , 3rd and 6th month , SEKG in the 4th month and recatheterization for angiographic control in the 6th month .", "entity": [], "task": "NER"}
{"text": "The practice of measuring of AChE levels in acute poisoning is limited .", "entity": [{"entity": "AChE", "entity_type": "GENE", "pos": [29, 33]}], "task": "NER"}
{"text": "M . , Adrich , Z . , Fournet , B . , Capon , C . , Bonicel , J .", "entity": [], "task": "NER"}
{"text": "Confocal fluorescent microscopy analysis demonstrated that WT , VaI , and VaII all distribute equally to the cell surface while , as expected , a WT mutant lacking the two C - terminal valine residues does not .", "entity": [], "task": "NER"}
{"text": "The amount of ERCC1 detectable by immunoblotting is reduced in group 1 , group 4 and XP - F extracts .", "entity": [{"entity": "ERCC1", "entity_type": "GENE", "pos": [14, 19]}], "task": "NER"}
{"text": "Letter : Ballistocardiography .", "entity": [], "task": "NER"}
{"text": "Metabolic studies of tetrabenazine , a psychotropic drug in animals and man .", "entity": [], "task": "NER"}
{"text": "From the frozen specimen , a large number of sections with good morphologic characteristics may be produced .", "entity": [], "task": "NER"}
{"text": "Gene transcripts are detected on tissues such as bovine liver , kidney , lung , and brain .", "entity": [], "task": "NER"}
{"text": "Plasma enteroglucagon was measured before and during three hours after a standard meal in 21 untreated adult patients with suspected coeliac disease who all had villous atrophy of the small intestinal mucosa and malabsorption , and in nine control subjects .", "entity": [{"entity": "Plasma enteroglucagon", "entity_type": "GENE", "pos": [0, 21]}], "task": "NER"}
{"text": "In this report , we establish that the heteromeric CCAAT - binding factor CBF is the major component of the C1 - binding factor ( C1F ) in human cells .", "entity": [{"entity": "CCAAT - binding factor", "entity_type": "GENE", "pos": [51, 73]}, {"entity": "CBF", "entity_type": "GENE", "pos": [74, 77]}, {"entity": "C1 - binding factor", "entity_type": "GENE", "pos": [108, 127]}, {"entity": "C1F", "entity_type": "GENE", "pos": [130, 133]}], "task": "NER"}
{"text": "This growth - inhibitory effect was suppressed by the mpk1 delta mutation , suggesting that hyperactivation of the Mpk1 pathway is toxic to cells .", "entity": [{"entity": "mpk1 delta", "entity_type": "GENE", "pos": [54, 64]}, {"entity": "Mpk1", "entity_type": "GENE", "pos": [115, 119]}], "task": "NER"}
{"text": "The human PAX8 gene generates at least five different alternatively spliced transcripts encoding different PAX8 isoforms .", "entity": [{"entity": "human PAX8 gene", "entity_type": "GENE", "pos": [4, 19]}, {"entity": "PAX8 isoforms", "entity_type": "GENE", "pos": [107, 120]}], "task": "NER"}
{"text": "The use of specific somatic cell hybrids have allowed us to locate the YAC contig telomeric to the D3F15S2 locus , in a region which is frequently deleted in lung carcinomas .", "entity": [{"entity": "D3F15S2 locus", "entity_type": "GENE", "pos": [99, 112]}], "task": "NER"}
{"text": "A close homologue of the APK2a gene , named APK2b , was also isolated from the Arabidopsis cDNA library .", "entity": [{"entity": "APK2a gene", "entity_type": "GENE", "pos": [25, 35]}, {"entity": "APK2b", "entity_type": "GENE", "pos": [44, 49]}], "task": "NER"}
{"text": "Characterization of Chlamydomonas reinhardtii zygote - specific cDNAs that encode novel proteins containing ankyrin repeats and WW domains .", "entity": [{"entity": "ankyrin", "entity_type": "GENE", "pos": [108, 115]}], "task": "NER"}
{"text": "Subsequent analysis revealed that MyD88 possesses a unique modular structure , which consists of an N - terminal \" death domain , \" similar to the intracellular segments of TNF receptor 1 and Fas , and a C - terminal region related to the cytoplasmic domains of the Drosophila morphogen Toll and vertebrate interleukin - 1 receptors .", "entity": [{"entity": "MyD88", "entity_type": "GENE", "pos": [34, 39]}, {"entity": "TNF receptor 1", "entity_type": "GENE", "pos": [173, 187]}, {"entity": "Fas", "entity_type": "GENE", "pos": [192, 195]}, {"entity": "Drosophila morphogen Toll", "entity_type": "GENE", "pos": [266, 291]}, {"entity": "interleukin - 1 receptors", "entity_type": "GENE", "pos": [307, 332]}], "task": "NER"}
{"text": "A . nidulans transformants secreted high amounts of PGI and PGII in comparison to the previously characterized A . niger transformants and a novel polygalacturonase ( PGC ) was produced at high levels by A . nidulans transformed with the subcloned pgaC gene .", "entity": [{"entity": "PGI", "entity_type": "GENE", "pos": [52, 55]}, {"entity": "PGII", "entity_type": "GENE", "pos": [60, 64]}, {"entity": "polygalacturonase", "entity_type": "GENE", "pos": [147, 164]}, {"entity": "PGC", "entity_type": "GENE", "pos": [167, 170]}, {"entity": "pgaC gene", "entity_type": "GENE", "pos": [248, 257]}], "task": "NER"}
{"text": "Role of zinc - finger proteins Sp1 and zif268 / egr - 1 in transcriptional regulation of the human synaptobrevin II gene .", "entity": [{"entity": "zinc - finger proteins Sp1", "entity_type": "GENE", "pos": [8, 34]}, {"entity": "zif268", "entity_type": "GENE", "pos": [39, 45]}, {"entity": "egr - 1", "entity_type": "GENE", "pos": [48, 55]}, {"entity": "human synaptobrevin II gene", "entity_type": "GENE", "pos": [93, 120]}], "task": "NER"}
{"text": "However , the recovery curve of the R2 component of the blink reflex diminished in patients with tension - type headache compared with the other groups .", "entity": [], "task": "NER"}
{"text": "The GvpE protein involved in the regulation of gas vesicles synthesis in halophilic archaea has been identified as the transcriptional activator for the promoter located upstream of the gvpA gene encoding the major gas vesicle structural protein GvpA .", "entity": [{"entity": "GvpE protein", "entity_type": "GENE", "pos": [4, 16]}, {"entity": "gvpA gene", "entity_type": "GENE", "pos": [186, 195]}, {"entity": "GvpA", "entity_type": "GENE", "pos": [246, 250]}], "task": "NER"}
{"text": "TFIIIB assembles autonomously on the upstream promoter of the yeast U6 snRNA ( SNR6 ) gene in vitro , through the interaction of its TBP subunit with a consensus TATA box located at base pair - 30 .", "entity": [{"entity": "TFIIIB", "entity_type": "GENE", "pos": [0, 6]}, {"entity": "yeast U6 snRNA", "entity_type": "GENE", "pos": [62, 76]}, {"entity": "SNR6", "entity_type": "GENE", "pos": [79, 83]}, {"entity": "TBP subunit", "entity_type": "GENE", "pos": [133, 144]}], "task": "NER"}
{"text": "Effect of bromocriptine and metoclopramide on serum prolactin levels in patients with amyotrophic lateral sclerosis .", "entity": [{"entity": "serum prolactin", "entity_type": "GENE", "pos": [46, 61]}], "task": "NER"}
{"text": "Experience in using the Romashka - 1 laser surgical unit in treating suppurative wounds", "entity": [], "task": "NER"}
{"text": "At a cutoff point for KISA % of 100 , 280 of 281 participants ( 99 . 6 % ) were correctly classified .", "entity": [], "task": "NER"}
{"text": "To evaluate the effect of selective thromboxane A2 blockade on clinical findings and platelet reactivity in refractory unstable angina , OKY - 046 ( 600 mg / day , p . o . ) was administered to another 14 patients with refractory unstable angina in addition to the conventional therapy .", "entity": [], "task": "NER"}
{"text": "The AP - 1 recruited by ARF1 . GTP is released from the Golgi membrane by treatment with 1 M Tris - HCl ( pH 7 ) or upon reincubation at 37 degreesC , whereas AP - 1 recruited with GTPgammaS or by a constitutively active point mutant , ARF1 ( Q71L ) , remains membrane bound after either treatment .", "entity": [{"entity": "AP - 1", "entity_type": "GENE", "pos": [4, 10]}, {"entity": "ARF1 . GTP", "entity_type": "GENE", "pos": [24, 34]}, {"entity": "AP - 1", "entity_type": "GENE", "pos": [159, 165]}, {"entity": "ARF1 ( Q71L )", "entity_type": "GENE", "pos": [236, 249]}], "task": "NER"}
{"text": "In K562 cells , using the bicistronic vector , selection with colchicine led to at least 20 - fold higher expression of the MDR1 gene product than did selection with G418 , suggesting that the stringent MDR1 selection system is very efficient for obtaining overexpression of foreign genes .", "entity": [{"entity": "MDR1 gene product", "entity_type": "GENE", "pos": [124, 141]}, {"entity": "MDR1", "entity_type": "GENE", "pos": [203, 207]}], "task": "NER"}
{"text": "A surge in the rate of ascorbyl radical production , directly correlated with oxyradical stress and an abrupt fall in superoxide dismutase activity in the granuloma , indicates ' switching on ' of a free radical - dependent machinery for the formation of granuloma after vasectomy .", "entity": [{"entity": "superoxide dismutase", "entity_type": "GENE", "pos": [118, 138]}], "task": "NER"}
{"text": "The vaccine was highly immunogenic , since 111 of 113 patients ( 98 % ) produced anti - HBs ( 10 mIU / ml or more ) .", "entity": [{"entity": "anti - HBs", "entity_type": "GENE", "pos": [81, 91]}], "task": "NER"}
{"text": "Papillomavirus type 16 oncogenes downregulate expression of interferon - responsive genes and upregulate proliferation - associated and NF - kappaB - responsive genes in cervical keratinocytes .", "entity": [{"entity": "interferon", "entity_type": "GENE", "pos": [60, 70]}, {"entity": "NF - kappaB", "entity_type": "GENE", "pos": [136, 147]}], "task": "NER"}
{"text": "A model for the SMase - sphingomyelin complex structure was built to investigate how the SMase specifically recognizes its substrate .", "entity": [{"entity": "SMase", "entity_type": "GENE", "pos": [16, 21]}, {"entity": "SMase", "entity_type": "GENE", "pos": [89, 94]}], "task": "NER"}
{"text": "MADS - box genes in plants are a diverse class of transcription factors that are involved in regulating developmental processes , particularly meristem and organ identity during floral development .", "entity": [{"entity": "MADS - box genes", "entity_type": "GENE", "pos": [0, 16]}], "task": "NER"}
{"text": "RESULTS : In the test data set , the single - sample model was confirmed to give excellent estimation of the AUC : AUC ( mg / ml x min ) = 0 . 93 x C3h + 0 . 47 ( MPE % = 4 . 4 % , RMSE % = 8 . 9 % ) .", "entity": [], "task": "NER"}
{"text": "Our results show that a combination of Pfu exo ( - ) at the primer extension step and Taq at the PCR amplification step is ideal for in vivo DNA analysis and DNA damage mapping using LMPCR .", "entity": [{"entity": "Pfu exo ( - )", "entity_type": "GENE", "pos": [39, 52]}, {"entity": "Taq", "entity_type": "GENE", "pos": [86, 89]}], "task": "NER"}
{"text": "KU - 1257 also significantly accelerated the healing of acetic acid - induced duodenal ulcers as well as famotidine and roxatidine acetate .", "entity": [], "task": "NER"}
{"text": "Prolongation of prothrombin time was not due to depletion of vitamin K - dependent coagulation factors or manifest fibrinolysis , but due to the presence of circulating fibrinogen fibrinmonomer - FDP complexes .", "entity": [{"entity": "prothrombin", "entity_type": "GENE", "pos": [16, 27]}, {"entity": "fibrinogen fibrinmonomer", "entity_type": "GENE", "pos": [169, 193]}], "task": "NER"}
{"text": "Clostridium botulinum in marine sediment", "entity": [], "task": "NER"}
{"text": "Upstream stimulatory factor USF is a human transcriptional activation factor , which uses a basic / helix - loop - helix / leucin zipper ( b / HLH / Z ) motif to homodimerize and recognize specific sequences in the promoter region of both nuclear and viral genes transcribed by RNA polymerase II .", "entity": [{"entity": "Upstream stimulatory factor", "entity_type": "GENE", "pos": [0, 27]}, {"entity": "USF", "entity_type": "GENE", "pos": [28, 31]}, {"entity": "RNA polymerase II", "entity_type": "GENE", "pos": [278, 295]}], "task": "NER"}
{"text": "Fusion of mouse CD8 + class I MHC - restricted T cells with the BW5147 thymoma invariably yields CD8 - hybridomas in which RNA transcribed from the CD8 alpha ( Lyt - 2 ) gene is undetectable .", "entity": [{"entity": "mouse CD8 +", "entity_type": "GENE", "pos": [10, 21]}, {"entity": "class I MHC", "entity_type": "GENE", "pos": [22, 33]}, {"entity": "CD8 -", "entity_type": "GENE", "pos": [97, 102]}, {"entity": "CD8 alpha", "entity_type": "GENE", "pos": [148, 157]}, {"entity": "Lyt - 2", "entity_type": "GENE", "pos": [160, 167]}], "task": "NER"}
{"text": "Consistent with this hypothesis , alpha1 - PDX prevents cleavage of BMP - 4 in an oocyte translation assay .", "entity": [{"entity": "alpha1 - PDX", "entity_type": "GENE", "pos": [34, 46]}, {"entity": "BMP - 4", "entity_type": "GENE", "pos": [68, 75]}], "task": "NER"}
{"text": "Convergence of trigeminal input with visceral and phrenic inputs on primate C1 - C2 spinothalamic tract neurons .", "entity": [], "task": "NER"}
{"text": "In this study we cloned the cDNA of AD1 Ag from a rat basophilic leukemia 2H3 cDNA library .", "entity": [{"entity": "AD1 Ag", "entity_type": "GENE", "pos": [36, 42]}], "task": "NER"}
{"text": "Several sequences resembling binding sites for liver - and fat body - specific transcription factors were identified within 1 kb upstream and downstream of the gene .", "entity": [], "task": "NER"}
{"text": "Root surface caries incidence in the groups inoculated with A . viscosus and A . viscosus plus S . sobrinus did not differ .", "entity": [], "task": "NER"}
{"text": "METHODS AND RESULTS : The QTd and JTd intervals in 39 children with long QT syndrome were compared to those of 50 normal age - matched children .", "entity": [], "task": "NER"}
{"text": "The prgX gene is adjacent to prgQ which provides the promoter for prgB expression .", "entity": [{"entity": "prgX gene", "entity_type": "GENE", "pos": [4, 13]}, {"entity": "prgQ", "entity_type": "GENE", "pos": [29, 33]}, {"entity": "prgB", "entity_type": "GENE", "pos": [66, 70]}], "task": "NER"}
{"text": "A Frank vectorcardiogram was recorded before and every 15 - 30 minutes for 10 hours after the occlusion .", "entity": [], "task": "NER"}
{"text": "The treatment of Sudeck ' s atrophy in the upper limb by sympathetic blockade .", "entity": [], "task": "NER"}
{"text": "Frequency of recurrence of fibroids after myomectomy has been evaluated in 145 women ( median age 38 years , range 21 - 52 ) who underwent myomectomy .", "entity": [], "task": "NER"}
{"text": "There is a good correlation between the occurrence in any particular vascular segment of the transient contractile response and intrinsic tone as assessed by relaxation to papaverine ( 10 ( - 6 ) M ) .", "entity": [], "task": "NER"}
{"text": "The antimicrobial of choice for initial prophylactic therapy among asymptomatic pregnant women exposed to Bacillus anthracis is ciprofloxacin , 500 mg twice a day for 60 days .", "entity": [], "task": "NER"}
{"text": "Spontaneous coronary artery spasm during coronary angiography in a patient with exercise - induced ST segment elevation .", "entity": [], "task": "NER"}
{"text": "Nickel release from tools on the Swedish market .", "entity": [], "task": "NER"}
{"text": "There was no correlation between starting platelet - associated IgG levels or changes in platelet - associated IgG levels with therapy and the increment in the patient ' s platelet count .", "entity": [{"entity": "IgG", "entity_type": "GENE", "pos": [64, 67]}, {"entity": "IgG", "entity_type": "GENE", "pos": [111, 114]}], "task": "NER"}
{"text": "The receptor for CSF - 1 , c - Fms , is expressed in osteoclasts , possesses intrinsic tyrosine - kinase activity , and signals via rapid phosphorylation of selected proteins .", "entity": [{"entity": "CSF - 1", "entity_type": "GENE", "pos": [17, 24]}, {"entity": "c - Fms", "entity_type": "GENE", "pos": [27, 34]}, {"entity": "tyrosine - kinase", "entity_type": "GENE", "pos": [87, 104]}], "task": "NER"}
{"text": "In a rat model of SAH , we assessed BBB changes by means of the quantitative [ 14C ] - alpha - aminoisobutyric acid technique .", "entity": [], "task": "NER"}
{"text": "BAG - 1 also prevented growth arrest following UV - irradiation - induced genotoxic injury without interfering with accumulation of p53 protein or p21 ( waf - 1 ) expression .", "entity": [{"entity": "BAG - 1", "entity_type": "GENE", "pos": [0, 7]}, {"entity": "p53 protein", "entity_type": "GENE", "pos": [132, 143]}, {"entity": "p21", "entity_type": "GENE", "pos": [147, 150]}, {"entity": "waf - 1", "entity_type": "GENE", "pos": [153, 160]}], "task": "NER"}
{"text": "During the last three days of the study , mean urine osmolality ( Uosm ) and free water reabsorption ( TCH2O ) increased significantly : [ formula : see text ] .", "entity": [], "task": "NER"}
{"text": "[ ( OP ) 2Cu ] + also detected protections in the C alpha - helix , the interdomain hinge , and beta - strands 2 - 7 .", "entity": [], "task": "NER"}
{"text": "When O - 2A / c - myc cells underwent terminal differentiation APprog complexes were lost and conventional AP - 1 DNA - binding activity became evident , particularly in astrocytes .", "entity": [{"entity": "c - myc", "entity_type": "GENE", "pos": [14, 21]}, {"entity": "APprog complexes", "entity_type": "GENE", "pos": [63, 79]}, {"entity": "AP - 1", "entity_type": "GENE", "pos": [107, 113]}], "task": "NER"}
{"text": "The gene , from the initiator methionine to the polyadenylation site , is contained within 13 244 basepairs and contains 19 exons .", "entity": [], "task": "NER"}
{"text": "To study structural diversity of the three homologous loci encoding a KN1 - like homeobox protein in the hexaploid wheat genome , we isolated clones from a cDNA library of young spikes of Japanese common wheat cultivar ' Norin 26 ' .", "entity": [{"entity": "KN1 - like homeobox protein", "entity_type": "GENE", "pos": [70, 97]}], "task": "NER"}
{"text": "Treatment is based on antifungal drugs , most frequently nystatin , amphotericin B and ketoconazole .", "entity": [], "task": "NER"}
{"text": "Controversy exists regarding both the natural life cycle for this parasite as well as the species identity of opossum Sarcocystis .", "entity": [], "task": "NER"}
{"text": "Here we report that components of the Ras / Raf / MAPK pathway are constitutively activated in these lck - transformed immature thymoblasts . p56 ( lck ) utilizes Shc and Grb2 adaptors to mediate activation of p21 ( ras ) in the thymoblast lines by promoting tyrosine phosphorylation of the Shc protein and constitutive interaction between Shc and Grb2 .", "entity": [{"entity": "Ras", "entity_type": "GENE", "pos": [38, 41]}, {"entity": "Raf", "entity_type": "GENE", "pos": [44, 47]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [50, 54]}, {"entity": "lck", "entity_type": "GENE", "pos": [101, 104]}, {"entity": "p56", "entity_type": "GENE", "pos": [142, 145]}, {"entity": "lck", "entity_type": "GENE", "pos": [148, 151]}, {"entity": "Shc", "entity_type": "GENE", "pos": [163, 166]}, {"entity": "Grb2 adaptors", "entity_type": "GENE", "pos": [171, 184]}, {"entity": "p21", "entity_type": "GENE", "pos": [210, 213]}, {"entity": "ras", "entity_type": "GENE", "pos": [216, 219]}, {"entity": "Shc protein", "entity_type": "GENE", "pos": [291, 302]}, {"entity": "Shc", "entity_type": "GENE", "pos": [340, 343]}, {"entity": "Grb2", "entity_type": "GENE", "pos": [348, 352]}], "task": "NER"}
{"text": "Unfractionated heparin ( UFH ) given at a dose of 0 . 3 mg x kg - 1 bolus + 0 . 3 mg x kg - 1 x h - 1 infusion did not improve the incidence of reperfusion or lower the incidence of reocclusion .", "entity": [], "task": "NER"}
{"text": "The quantification limit was 50 ng / ml for each of PHT , m - HPPH and p - HPPH .", "entity": [], "task": "NER"}
{"text": "Plasma hemopexin homeostasis during the acute phase response .", "entity": [{"entity": "Plasma hemopexin", "entity_type": "GENE", "pos": [0, 16]}], "task": "NER"}
{"text": "Our aim was to check whether , during PG - DS administration , serum lipase activity changes simultaneously with serum amylase activity , and , if so , what the reason is for the detected change .", "entity": [{"entity": "lipase", "entity_type": "GENE", "pos": [69, 75]}, {"entity": "amylase", "entity_type": "GENE", "pos": [119, 126]}], "task": "NER"}
{"text": "( i ) The chimeric gene consisting of the coding and 5 ' nontranslated leader regions of the TK gene fused to portions of the domain of alpha gene 0 extending largely upstream from the site of initiation of transcription of alpha gene 0 was regulated in the same fashion as the alpha 4 - and alpha 27 - TK chimeras .", "entity": [{"entity": "TK gene", "entity_type": "GENE", "pos": [93, 100]}, {"entity": "alpha gene 0", "entity_type": "GENE", "pos": [136, 148]}, {"entity": "alpha gene 0", "entity_type": "GENE", "pos": [224, 236]}, {"entity": "alpha 4 - and alpha 27 - TK", "entity_type": "GENE", "pos": [278, 305]}], "task": "NER"}
{"text": "Cytokines and steroid hormones use different sets of signal transduction pathways , which seem to be unrelated .", "entity": [], "task": "NER"}
{"text": "This is the most northern and , at the same time largest , Q fever epidemic recorded in Germany over the last 28 years .", "entity": [], "task": "NER"}
{"text": "Genetic analysis of the role of herpes simplex virus type 1 glycoprotein K in infectious virus production and egress .", "entity": [{"entity": "herpes simplex virus type 1 glycoprotein K", "entity_type": "GENE", "pos": [32, 74]}], "task": "NER"}
{"text": "The 5 ' half of the EWS gene has recently been described to be fused to the 3 ' regions of genes encoding the DNA - binding domain of several transcriptional regulators , including ATF1 , FLI - 1 , and ERG , in several human tumors .", "entity": [{"entity": "EWS gene", "entity_type": "GENE", "pos": [20, 28]}, {"entity": "ATF1", "entity_type": "GENE", "pos": [181, 185]}, {"entity": "FLI - 1", "entity_type": "GENE", "pos": [188, 195]}, {"entity": "ERG", "entity_type": "GENE", "pos": [202, 205]}], "task": "NER"}
{"text": "We used high - resolution ultrasound to characterize postprandial antral excursion characteristics in 15 healthy volunteers .", "entity": [], "task": "NER"}
{"text": "Multivariable logistic regression showed that mean blood glucose level for the first 2 days ( p = 0 . 002 ) , obesity ( p < 0 . 002 ) , and use of the internal mammary artery ( p < 0 . 02 ) were all independent predictors of deep wound infection .", "entity": [], "task": "NER"}
{"text": "Fine tangled pili expressed by Haemophilus ducreyi are a novel class of pili .", "entity": [], "task": "NER"}
{"text": "CONCLUSIONS : The RRM is one of the most common and best characterized RNA - binding motifs .", "entity": [], "task": "NER"}
{"text": "Torsion of the contralateral testis 5 years after orchiopexy .", "entity": [], "task": "NER"}
{"text": "Serum levels of total and specific immunoglobulin E ( IgE ) have been determined by radioimmunoassays in sixty - nine allergic subjects .", "entity": [{"entity": "specific immunoglobulin E", "entity_type": "GENE", "pos": [26, 51]}, {"entity": "IgE", "entity_type": "GENE", "pos": [54, 57]}], "task": "NER"}
{"text": "The largest one probably corresponds to the precursor form of PS2 in E . coli .", "entity": [{"entity": "PS2", "entity_type": "GENE", "pos": [62, 65]}], "task": "NER"}
{"text": "Transcriptional analysis indicates that human TBP functions poorly at promoters recognized by RNA polymerases I and III and at RNA Pol II promoters lacking a conventional TATA element .", "entity": [{"entity": "human TBP", "entity_type": "GENE", "pos": [40, 49]}, {"entity": "RNA polymerases I and III", "entity_type": "GENE", "pos": [94, 119]}, {"entity": "RNA Pol II promoters", "entity_type": "GENE", "pos": [127, 147]}], "task": "NER"}
{"text": "Elements of the hAT transposon family , such as the maize activator ( Ac ) , have been discovered in a large number of eukaryotic species .", "entity": [{"entity": "hAT transposon family", "entity_type": "GENE", "pos": [16, 37]}, {"entity": "maize activator", "entity_type": "GENE", "pos": [52, 67]}, {"entity": "Ac", "entity_type": "GENE", "pos": [70, 72]}], "task": "NER"}
{"text": "The identification of SRP54sc and SRP54sp provides the first evidence for SRP related proteins in yeast .", "entity": [{"entity": "SRP54sc", "entity_type": "GENE", "pos": [22, 29]}, {"entity": "SRP54sp", "entity_type": "GENE", "pos": [34, 41]}, {"entity": "SRP", "entity_type": "GENE", "pos": [74, 77]}], "task": "NER"}
{"text": "We have isolated two H19 cDNAs ( AP and ES ) that contain this ORF4 and correspond to incomplete copies of the unique 2 . 3 kb H19 RNA .", "entity": [{"entity": "H19 cDNAs", "entity_type": "GENE", "pos": [21, 30]}, {"entity": "AP", "entity_type": "GENE", "pos": [33, 35]}, {"entity": "ES", "entity_type": "GENE", "pos": [40, 42]}, {"entity": "2 . 3 kb H19 RNA", "entity_type": "GENE", "pos": [118, 134]}], "task": "NER"}
{"text": "Urease activity , judged as the amount of ammonia production from urea , could be measured at 25 ng per tube ( S / N = 1 . 5 ) with Jack bean meal urease .", "entity": [{"entity": "Urease", "entity_type": "GENE", "pos": [0, 6]}, {"entity": "Jack bean meal urease", "entity_type": "GENE", "pos": [132, 153]}], "task": "NER"}
{"text": "Radioimmunoassay of plasma gonadotropins ; problems of specificity", "entity": [{"entity": "plasma gonadotropins", "entity_type": "GENE", "pos": [20, 40]}], "task": "NER"}
{"text": "Tissue expansion was used successfully to prepare adequate soft tissue for closure following a difficult clubfoot correction .", "entity": [], "task": "NER"}
{"text": "Legionella antibodies in domestic animals", "entity": [{"entity": "Legionella antibodies", "entity_type": "GENE", "pos": [0, 21]}], "task": "NER"}
{"text": "In a previous study of transforming growth factor - beta1 - mediated inhibition of the cyclin A promoter , we mapped the inhibitory effect to the ATF site ; in the present study of IFN - gamma treatment , functional analysis by transient transfection showed that inhibition of the cyclin A promoter persisted despite mutation of the ATF , NF - Y , or CDE elements .", "entity": [{"entity": "transforming growth factor - beta1", "entity_type": "GENE", "pos": [23, 57]}, {"entity": "cyclin A promoter", "entity_type": "GENE", "pos": [87, 104]}, {"entity": "ATF site", "entity_type": "GENE", "pos": [146, 154]}, {"entity": "IFN - gamma", "entity_type": "GENE", "pos": [181, 192]}, {"entity": "cyclin A promoter", "entity_type": "GENE", "pos": [281, 298]}, {"entity": "ATF", "entity_type": "GENE", "pos": [333, 336]}, {"entity": "NF - Y", "entity_type": "GENE", "pos": [339, 345]}], "task": "NER"}
{"text": "No significant difference was seen found between the two groups in the degree of postoperative deterioration in cardiopulmonary function or in interleukin - 6 levels .", "entity": [{"entity": "interleukin - 6", "entity_type": "GENE", "pos": [143, 158]}], "task": "NER"}
{"text": "We show that GCNF binds to one of the two DRO sequences in the Prm1 promoter , and to the DRO sequence in the Prm2 promoter in a specific manner .", "entity": [{"entity": "GCNF", "entity_type": "GENE", "pos": [13, 17]}, {"entity": "Prm1 promoter", "entity_type": "GENE", "pos": [63, 76]}, {"entity": "Prm2 promoter", "entity_type": "GENE", "pos": [110, 123]}], "task": "NER"}
{"text": "The strategy uses RNA ligase to add DNA oligonucleotide priming sites to the RNA for subsequent reverse transcription and PCR ( RNA ligase , reverse transcription - PCR , or RL / RT / PCR ) .", "entity": [{"entity": "RNA ligase", "entity_type": "GENE", "pos": [18, 28]}, {"entity": "RNA ligase", "entity_type": "GENE", "pos": [128, 138]}], "task": "NER"}
{"text": "From 1977 to 1985 , 42 patients with squamous cell carcinoma of the anal canal were treated with mitomycin C ( 15 mg / m2 ) and 5 - fluorouracil ( 750 mg / m2 ) on day 1 , 5 - FU ( 750 mg / m2 / d ) alone on days 2 to 5 , and radiation therapy ( 3000 cGy ) on days 7 to 28 .", "entity": [], "task": "NER"}
{"text": "Effect of choline magnesium trisalicylate on prostacyclin production by isolated vascular tissue of the rat .", "entity": [], "task": "NER"}
{"text": "The magnitude of all four parameters increased in an exponential fashion with increasing sperm number up to 400 x 10 ( 6 ) per ejaculate .", "entity": [], "task": "NER"}
{"text": "A sharp transition from a random chaotic state to a correlated turbulent state of finite coherence time is found when the Rayleigh number becomes larger than a critical value Ra ( c ) approximately equal to 5 x 10 ( 7 ) .", "entity": [], "task": "NER"}
{"text": "In HMEC stably transfected with an ER mutant containing a deletion in the second zinc finger of the DNA - binding domain , E and HT had different effects on EBBP gene expression ; EBBP regulation by E was dramatically reduced while the effects of HT were augmented .", "entity": [{"entity": "ER mutant", "entity_type": "GENE", "pos": [35, 44]}, {"entity": "EBBP gene", "entity_type": "GENE", "pos": [157, 166]}, {"entity": "EBBP", "entity_type": "GENE", "pos": [180, 184]}], "task": "NER"}
{"text": "6 h after ingestion of aspirin on day 1 to day 14 , both TX and PGI2 levels also significantly decreased ( p < 0 . 0001 ) .", "entity": [], "task": "NER"}
{"text": "When transfected into HepG2 cells , which lack C / EBP alpha , the mouse ob promoter was only weakly active .", "entity": [{"entity": "C / EBP alpha", "entity_type": "GENE", "pos": [47, 60]}, {"entity": "mouse ob promoter", "entity_type": "GENE", "pos": [67, 84]}], "task": "NER"}
{"text": "Desarrollo de un modelo matematico general para los procesos fermentativos , Cinetica de la degradacion anaerobia , Ph . D .", "entity": [], "task": "NER"}
{"text": "NF - kappaB DNA - protein binding and ICAM - 1 promoter activity were enhanced by IL - 1beta and these effects were inhibited by tyrphostin 23 , but not by PD 98059 or SB 203580 .", "entity": [{"entity": "NF - kappaB", "entity_type": "GENE", "pos": [0, 11]}, {"entity": "ICAM - 1 promoter", "entity_type": "GENE", "pos": [38, 55]}, {"entity": "IL - 1beta", "entity_type": "GENE", "pos": [82, 92]}], "task": "NER"}
{"text": "In murine cells , FPGS expression is controlled by two promoters that , as we show here , vary substantially in their efficiency , at least in the context of a reporter gene assay .", "entity": [{"entity": "FPGS", "entity_type": "GENE", "pos": [18, 22]}], "task": "NER"}
{"text": "Quantitative measurement of antigamma globulin factors ( rheumatoid factors ) using laser - nephelometry in comparison with the latex agglutination test and the Waaler - Rose test", "entity": [{"entity": "antigamma globulin factors", "entity_type": "GENE", "pos": [28, 54]}, {"entity": "rheumatoid factors", "entity_type": "GENE", "pos": [57, 75]}], "task": "NER"}
{"text": "Disruption of INP53 , but not the related INP51 and INP52 genes , resulted in alpha - factor maturation defects and exacerbated alpha - factor maturation defects when combined with chc1 - 521 .", "entity": [{"entity": "INP53", "entity_type": "GENE", "pos": [14, 19]}, {"entity": "INP51", "entity_type": "GENE", "pos": [42, 47]}, {"entity": "INP52 genes", "entity_type": "GENE", "pos": [52, 63]}, {"entity": "alpha - factor", "entity_type": "GENE", "pos": [78, 92]}, {"entity": "alpha - factor", "entity_type": "GENE", "pos": [128, 142]}, {"entity": "chc1 - 521", "entity_type": "GENE", "pos": [181, 191]}], "task": "NER"}
{"text": "The complete nucleotide sequence of odontoglossum ringspot virus ( Cy - 1 strain ) genomic RNA .", "entity": [], "task": "NER"}
{"text": "Paradoxically there is a decrease in the level of soluble A beta secreted from the cells .", "entity": [{"entity": "soluble A beta", "entity_type": "GENE", "pos": [50, 64]}], "task": "NER"}
{"text": "When translated in - frame with PKC zeta , a stop codon is located 28 amino acids towards the N - terminus of the divergence point and the intervening sequence lacks an expected initiating methionine . psi PKC zeta is non - functional in terms of protein synthesis since Western blotting with an antibody directed against the C - terminus of PKC zeta failed to reveal a protein smaller than PKC zeta , and synthetic psi PKC zeta RNA failed to support protein synthesis in a translation system in vitro .", "entity": [{"entity": "PKC zeta", "entity_type": "GENE", "pos": [32, 40]}, {"entity": "psi PKC zeta", "entity_type": "GENE", "pos": [202, 214]}, {"entity": "PKC zeta", "entity_type": "GENE", "pos": [342, 350]}, {"entity": "PKC zeta", "entity_type": "GENE", "pos": [391, 399]}, {"entity": "psi PKC zeta RNA", "entity_type": "GENE", "pos": [416, 432]}], "task": "NER"}
{"text": "Comparative ultrafiltration ( UF ) studies with BiGG and standard lactate ( La ) solutions in rabbits showed that net UF with La solution peaked at 2 h and decreased significantly at 4 h and 6 h .", "entity": [], "task": "NER"}
{"text": "The B . aphidicola argS - rrn DNA fragments from endosymbionts from seven species of aphids had promoter activities in E . coli which ranged from 6 to 135 % of that observed with a comparable DNA fragment of E . coli rrnB .", "entity": [{"entity": "B . aphidicola argS - rrn DNA fragments", "entity_type": "GENE", "pos": [4, 43]}, {"entity": "E . coli rrnB", "entity_type": "GENE", "pos": [208, 221]}], "task": "NER"}
{"text": "CONCLUSIONS : These principally structural studies support the hypothesis that the thrombus is a self - sustaining entity that may have significance in the pathophysiologic mechanism of abdominal aortic aneurysms .", "entity": [], "task": "NER"}
{"text": "The authors report about the exeresis of a pyelonephrictic left small kidney with laparoscopic surgery .", "entity": [], "task": "NER"}
{"text": "AMPK is a heterotrimer composed of a catalytic subunit ( alpha ) and two regulatory subunits ( beta and gamma ) .", "entity": [{"entity": "AMPK", "entity_type": "GENE", "pos": [0, 4]}], "task": "NER"}
{"text": "The genes encoding these carotenoids in E . herbicola Eho13 are clustered in a 7 kb DNA fragment .", "entity": [], "task": "NER"}
{"text": "Genetic diagnosis of respiratory diseases", "entity": [], "task": "NER"}
{"text": "Whereas mutant 6C4 specified a wild - type - size Pol protein , we detected no full - length Pol protein in 7E4 - infected cell extracts .", "entity": [{"entity": "mutant 6C4", "entity_type": "GENE", "pos": [8, 18]}, {"entity": "wild - type - size Pol protein", "entity_type": "GENE", "pos": [31, 61]}, {"entity": "full - length Pol protein", "entity_type": "GENE", "pos": [79, 104]}], "task": "NER"}
{"text": "Incidence of beta - thalassemia carriers and those deficient in erythrocyte glucose - 6 - phosphate dehydrogenase in the greater Buenos Aires area", "entity": [{"entity": "erythrocyte glucose - 6 - phosphate dehydrogenase", "entity_type": "GENE", "pos": [64, 113]}], "task": "NER"}
{"text": "Other toxicities attributed to CPT - 11 included dehydration , nausea , vomiting , and asthenia .", "entity": [], "task": "NER"}
{"text": "JCAHO moves to rewrite many rules to lessen hospitals ' regulatory burden .", "entity": [], "task": "NER"}
{"text": "A phylogenetic comparison of 32 species showed minor differences in the apoB mRNA sequence , and the apoB mRNA from 31 species was robustly edited in vitro .", "entity": [{"entity": "apoB mRNA sequence", "entity_type": "GENE", "pos": [72, 90]}, {"entity": "apoB mRNA", "entity_type": "GENE", "pos": [101, 110]}], "task": "NER"}
{"text": "The expression pattern of the reporter gene was compared to that of the endogenous PDGFbeta r gene .", "entity": [{"entity": "endogenous PDGFbeta r gene", "entity_type": "GENE", "pos": [72, 98]}], "task": "NER"}
{"text": "These transcripts directed the synthesis of three proteins : the virus trans - activator protein ( EIAV Tat ) encoded by ORF S1 , a protein of unknown function encoded by ORF S2 , and the virus envelope glycoprotein .", "entity": [{"entity": "virus trans - activator protein", "entity_type": "GENE", "pos": [65, 96]}, {"entity": "EIAV Tat", "entity_type": "GENE", "pos": [99, 107]}, {"entity": "envelope glycoprotein", "entity_type": "GENE", "pos": [194, 215]}], "task": "NER"}
{"text": "In addition , because SB203580 had no effect of TNF - or ceramide - induced apoptosis , our results strongly argue against a role for p38 MAPK in the induction of TNF - - or ceramide - induced apoptosis .", "entity": [{"entity": "TNF", "entity_type": "GENE", "pos": [48, 51]}, {"entity": "p38 MAPK", "entity_type": "GENE", "pos": [134, 142]}, {"entity": "TNF", "entity_type": "GENE", "pos": [163, 166]}], "task": "NER"}
{"text": "Seven Zebu cattle were also exposed to challenge at the same time .", "entity": [], "task": "NER"}
{"text": "To study the signaling pathways that regulate cytoskeletal rearrangements in T lymphocytes , we set up a conjugate formation assay using Jurkat T cells as effectors and cell - sized latex beads coated with various antibodies as artificial APCs .", "entity": [], "task": "NER"}
{"text": "YACs , BACs , cosmids , and STSs are defined to aid in further study of this gene .", "entity": [], "task": "NER"}
{"text": "The average coefficient of variation between assays for gas chromatography mass spectrometry was 5 . 8 % and for radioimmunoassay was 12 . 3 % , while the average coefficient of variation within assays for gas chromatography mass spectrometry was 4 . 9 % and for radioimmunoassay 6 . 9 % .", "entity": [], "task": "NER"}
{"text": "This chimera transduced IL - 4 - specific signals in response to IL - 2 binding and dramatically enhanced type 2 responses ( IL - 4 , IL - 5 , and immunoglobulin E production ) upon in vitro TCR stimulation or in vivo antigen challenge .", "entity": [{"entity": "IL - 4", "entity_type": "GENE", "pos": [24, 30]}, {"entity": "IL - 2", "entity_type": "GENE", "pos": [65, 71]}, {"entity": "IL - 4", "entity_type": "GENE", "pos": [125, 131]}, {"entity": "IL - 5", "entity_type": "GENE", "pos": [134, 140]}, {"entity": "immunoglobulin E", "entity_type": "GENE", "pos": [147, 163]}, {"entity": "TCR", "entity_type": "GENE", "pos": [191, 194]}], "task": "NER"}
{"text": "Soggy , a spermatocyte - specific gene , lies 3 . 8 kb upstream of and antipodal to TEAD - 2 , a transcription factor expressed at the beginning of mouse development .", "entity": [{"entity": "Soggy", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "TEAD - 2", "entity_type": "GENE", "pos": [84, 92]}], "task": "NER"}
{"text": "We previously demonstrated that AKT2 , a member of protein kinase B family , is activated by a number of growth factors via Ras and PI 3 - kinase signaling pathways .", "entity": [{"entity": "AKT2", "entity_type": "GENE", "pos": [32, 36]}, {"entity": "protein kinase B family", "entity_type": "GENE", "pos": [51, 74]}, {"entity": "Ras", "entity_type": "GENE", "pos": [124, 127]}, {"entity": "PI 3 - kinase", "entity_type": "GENE", "pos": [132, 145]}], "task": "NER"}
{"text": "This demonstrates the presence of a PKC - dependent pathway which functions independently from Lck in MAP kinase activation .", "entity": [{"entity": "PKC", "entity_type": "GENE", "pos": [36, 39]}, {"entity": "Lck", "entity_type": "GENE", "pos": [95, 98]}, {"entity": "MAP kinase", "entity_type": "GENE", "pos": [102, 112]}], "task": "NER"}
{"text": "Finally , transfection of Grb10 genes with specific mutations in their SH2 domains induces apoptosis in HTC - IR and COS - 7 cells .", "entity": [{"entity": "Grb10 genes", "entity_type": "GENE", "pos": [26, 37]}, {"entity": "SH2 domains", "entity_type": "GENE", "pos": [71, 82]}], "task": "NER"}
{"text": "Small t also inhibited the dephosphorylation of cAMP - dependent protein kinase ( PKA ) - phosphorylated CREB in rat liver nuclear extracts .", "entity": [{"entity": "Small t", "entity_type": "GENE", "pos": [0, 7]}, {"entity": "cAMP - dependent protein kinase", "entity_type": "GENE", "pos": [48, 79]}, {"entity": "PKA", "entity_type": "GENE", "pos": [82, 85]}, {"entity": "CREB", "entity_type": "GENE", "pos": [105, 109]}], "task": "NER"}
{"text": "Physical map of the genome of sonchus yellow net virus , a plant rhabdovirus with six genes and conserved gene junction sequences .", "entity": [], "task": "NER"}
{"text": "It is an untested argument that conventional beta - adrenoceptor antagonists possess unwanted metabolic effects that may counter some of their potential cardiac benefits .", "entity": [{"entity": "beta - adrenoceptor", "entity_type": "GENE", "pos": [45, 64]}], "task": "NER"}
{"text": "However , it is not easy to establish the diagnosis of thoracic MFH .", "entity": [], "task": "NER"}
{"text": "An 11 . 5 - kb intron is found at the end of transmembrane 6 , and the rest of the ORF is in exon 3 .", "entity": [], "task": "NER"}
{"text": "To assay for sequences that could potentially regulate Xenopus proenkephalin expression , we transfected constructs that contained upstream genomic sequences linked to the CAT reporter gene into various eukaryotic cell lines .", "entity": [{"entity": "Xenopus proenkephalin", "entity_type": "GENE", "pos": [55, 76]}, {"entity": "CAT reporter gene", "entity_type": "GENE", "pos": [172, 189]}], "task": "NER"}
{"text": "It is also conceivable that elevated insulin levels may cause hypertriglyceridaemia and possibly other abnormalities of lipid metabolism .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [37, 44]}], "task": "NER"}
{"text": "The effects of different sources of commercial rations on the humoral immune response of broilers to Newcastle disease vaccination .", "entity": [], "task": "NER"}
{"text": "To quantify the normal coupling patterns , fresh cadaveric human lumbar spine specimens ( L1 - S1 ) were used .", "entity": [], "task": "NER"}
{"text": "Deletion mutations were constructed , removing residues 2 - 30 , 31 - 60 , 61 - 90 , and 49 - 78 of the N - terminal cytoplasmic domain , as well as a missense mutation of a dileucine motif .", "entity": [], "task": "NER"}
{"text": "When the measured beta - galactosidase activity in the pWP - transfected cells was normalized to the pCH110 - transfected cells ( an appropriate control if the SV40 early region promoter functions constitutively in various cell lines ) , the results suggested that the promoter region of the PLP gene contains the information necessary for initiation of transcription in a C6 cell - specific manner .", "entity": [{"entity": "beta - galactosidase", "entity_type": "GENE", "pos": [18, 38]}, {"entity": "SV40 early region promoter", "entity_type": "GENE", "pos": [160, 186]}, {"entity": "PLP gene", "entity_type": "GENE", "pos": [292, 300]}], "task": "NER"}
{"text": "Indigenous microbial flora and the large intestine in tadpoles .", "entity": [], "task": "NER"}
{"text": "3 patients with acute leukaemia , HLA antibodies and thrombocytopenia refractory to random donor platelet transfusions were treated with high - dose i . v . immunoglobulin .", "entity": [{"entity": "HLA", "entity_type": "GENE", "pos": [34, 37]}, {"entity": "immunoglobulin", "entity_type": "GENE", "pos": [157, 171]}], "task": "NER"}
{"text": "Plasma renin activity in end - stage kidney disease .", "entity": [{"entity": "Plasma renin", "entity_type": "GENE", "pos": [0, 12]}], "task": "NER"}
{"text": "Computer system trains employees to meet JCAHO safety ED requirements .", "entity": [], "task": "NER"}
{"text": "The temporal sequence of organ failure was lung , clotting system , kidney , and liver .", "entity": [], "task": "NER"}
{"text": "All of this region is part of a prominent CpG island that may be acting as an extended , enhancer - independent promoter .", "entity": [], "task": "NER"}
{"text": "One function of p53 is in regulating cell cycle check - point control after DNA damage .", "entity": [{"entity": "p53", "entity_type": "GENE", "pos": [16, 19]}], "task": "NER"}
{"text": "100 .", "entity": [], "task": "NER"}
{"text": "IGF - I levels were measured in the CSF of 11 children with autism ( 4 females , 7 males ; mean age 3 . 8 years , SD 1 . 1 ) using a sensitive radioimmunoassay method and compared with levels in 11 control participants ( 6 females , 5 males ; mean age 3 . 8 years ) .", "entity": [{"entity": "IGF - I", "entity_type": "GENE", "pos": [0, 7]}], "task": "NER"}
{"text": "The XPR2 gene from Yarrowia lipolytica encodes an inducible alkaline extracellular protease .", "entity": [{"entity": "XPR2 gene", "entity_type": "GENE", "pos": [4, 13]}, {"entity": "alkaline extracellular protease", "entity_type": "GENE", "pos": [60, 91]}], "task": "NER"}
{"text": "Two closely related groups of transcripts , Sagrp1 and Sagrp2 , controlled by a circadian rhythm have been isolated .", "entity": [{"entity": "Sagrp1", "entity_type": "GENE", "pos": [44, 50]}, {"entity": "Sagrp2", "entity_type": "GENE", "pos": [55, 61]}], "task": "NER"}
{"text": "In patients autografted in CR1 , the transplant - related mortality ( TRM ) was 15 + / - 4 % , the relapse incidence ( RI ) was 58 + / - 5 % , the leukaemia - free survival ( LFS ) was 36 + / - 5 % and the overall survival was 47 + / - 5 % at 3 years .", "entity": [], "task": "NER"}
{"text": "However , H19 and IGF2 lie within a larger imprinted domain , and the gene specificity of H19 epimutation has been a persistent question .", "entity": [{"entity": "H19", "entity_type": "GENE", "pos": [10, 13]}, {"entity": "IGF2", "entity_type": "GENE", "pos": [18, 22]}, {"entity": "H19", "entity_type": "GENE", "pos": [90, 93]}], "task": "NER"}
{"text": "Antibiotics and CDCA - mediation are essential for symptomatic therapy .", "entity": [], "task": "NER"}
{"text": "The effectiveness and pathogenetic expediency of correcting disorders of lipid metabolism in atherosclerosis with enterosorbents is substantiated .", "entity": [], "task": "NER"}
{"text": "Adaptive effects of repeated immersion exposure on the human body", "entity": [], "task": "NER"}
{"text": "The human cDNA was cloned and sequenced ; it was shown to have an open reading frame encoding a 296 - amino - acid protein in which could be identified four peptides previously identified by micro - sequencing purified protein .", "entity": [], "task": "NER"}
{"text": "Octamer recognition is mediated by the POU domain , a conserved structural motif which - - like the zinc finger and leucine zipper - - defines a family of related transcription factors .", "entity": [{"entity": "POU", "entity_type": "GENE", "pos": [39, 42]}], "task": "NER"}
{"text": "Copyright 1998 The Association for the Study of Animal Behaviour .", "entity": [], "task": "NER"}
{"text": "Dipetalonema ( Acanthocheilonema ) didelphis sp . n .", "entity": [], "task": "NER"}
{"text": "Forty - five patients with recent - onset hyperthyroidism ( < 12 weeks ) were sex and menopause stratified and randomly allocated to treatment with carbimazole ( Neotomizol ) , carbimazole plus low dose CT ( Calsynar ; 100 IU / day , 2 days / week ) , or carbimazole plus high dose CT ( Calsynar ; 100 IU / day , 14 days / month ) .", "entity": [], "task": "NER"}
{"text": "The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter .", "entity": [{"entity": "promyelocytic leukemia protein", "entity_type": "GENE", "pos": [4, 34]}, {"entity": "Sp1", "entity_type": "GENE", "pos": [50, 53]}, {"entity": "epidermal growth factor receptor", "entity_type": "GENE", "pos": [94, 126]}], "task": "NER"}
{"text": "CTP , GDP , GTP , ITP ) did not affect the response .", "entity": [], "task": "NER"}
{"text": "Here , we characterize TCR / CD48 and TCR / CD28 costimulation in T cells expressing Lck Src homology 3 ( SH3 ) mutants .", "entity": [{"entity": "TCR", "entity_type": "GENE", "pos": [23, 26]}, {"entity": "CD48", "entity_type": "GENE", "pos": [29, 33]}, {"entity": "TCR", "entity_type": "GENE", "pos": [38, 41]}, {"entity": "CD28", "entity_type": "GENE", "pos": [44, 48]}, {"entity": "Lck", "entity_type": "GENE", "pos": [85, 88]}, {"entity": "Src homology 3", "entity_type": "GENE", "pos": [89, 103]}, {"entity": "SH3", "entity_type": "GENE", "pos": [106, 109]}], "task": "NER"}
{"text": "We also show that psbH and psbT are transcribed from the upstream psbB gene promoter , and that the psbH mRNA has its own target sequence for Mbb1 function .", "entity": [{"entity": "psbH", "entity_type": "GENE", "pos": [18, 22]}, {"entity": "psbT", "entity_type": "GENE", "pos": [27, 31]}, {"entity": "psbB gene promoter", "entity_type": "GENE", "pos": [66, 84]}, {"entity": "psbH mRNA", "entity_type": "GENE", "pos": [100, 109]}, {"entity": "Mbb1", "entity_type": "GENE", "pos": [142, 146]}], "task": "NER"}
{"text": "Thus , it appears that moxalactam is a reliable and useful antibiotic for the treatment of complicated urinary tract infections .", "entity": [], "task": "NER"}
{"text": "In the second , 37 students were given trimethoprim / sulphamethoxazole ( 160 mg TMP - SMX 800 mg ) , 38 TMP ( 200 mg ) , and in 35 a placebo was given b . i . d . for five days .", "entity": [], "task": "NER"}
{"text": "CONCLUSION : Men presenting with urethritis and women presenting with PID both have significantly greater peripheral blood mononuclear cell proliferative responses to the DK20 strain of C trachomatis than controls .", "entity": [], "task": "NER"}
{"text": "The infection of cells with Moloney murine leukemia virus ( M - MuLV ) causes an increase in specific cellular gene products , including the major histocompatibility complex ( MHC ) class I antigens .", "entity": [{"entity": "major histocompatibility complex ( MHC ) class I antigens", "entity_type": "GENE", "pos": [141, 198]}], "task": "NER"}
{"text": "Apparent Buschke - Loewenstein tumour of the penis .", "entity": [], "task": "NER"}
{"text": "The orthologs of the Y ( 1 ) and Y ( 2 ) subtypes display high amino acid sequence identities between pig , human , and mouse ( 92 % - 94 % ) , whereas the Y ( 4 ) , Y ( 5 ) , and y ( 6 ) subtypes display lower identities ( 76 % - 87 % ) .", "entity": [{"entity": "Y ( 1 )", "entity_type": "GENE", "pos": [21, 28]}, {"entity": "Y ( 2 ) subtypes", "entity_type": "GENE", "pos": [33, 49]}, {"entity": "Y ( 4 )", "entity_type": "GENE", "pos": [156, 163]}, {"entity": "Y ( 5 )", "entity_type": "GENE", "pos": [166, 173]}, {"entity": "y ( 6 ) subtypes", "entity_type": "GENE", "pos": [180, 196]}], "task": "NER"}
{"text": "In NIH 3T3 fibroblasts the high affinity IL - 2R bearing a deletion of a region rich in acidic amino acids ( the \" acidic \" region ) in the IL - 2R beta - chain failed to induce the tyrosine phosphorylation of MAP kinase as well as the expression of the all three nuclear proto - oncogenes .", "entity": [{"entity": "IL - 2R", "entity_type": "GENE", "pos": [41, 48]}, {"entity": "IL - 2R beta - chain", "entity_type": "GENE", "pos": [140, 160]}, {"entity": "MAP kinase", "entity_type": "GENE", "pos": [210, 220]}], "task": "NER"}
{"text": "Activation of the cytotactin promoter by the homeobox - containing gene Evx - 1 .", "entity": [{"entity": "cytotactin promoter", "entity_type": "GENE", "pos": [18, 37]}, {"entity": "homeobox - containing gene Evx - 1", "entity_type": "GENE", "pos": [45, 79]}], "task": "NER"}
{"text": "Of the private practices accredited in August 1995 , 40 . 6 per cent ( 122 ) participated .", "entity": [], "task": "NER"}
{"text": "Enhanced phospholipid hydrolysis with free fatty acid and thromboxane accumulation , increased release of excitatory amino acids , and decreased tissue magnesium levels may each serve to worsen secondary tissue damage and diminish neurologic recovery after spinal cord injury associated with acute alcohol intoxication .", "entity": [], "task": "NER"}
{"text": "This suggests that the ratio of IL - 6 to IL - 10 may be used to predict the injury severity after trauma .", "entity": [{"entity": "IL - 6", "entity_type": "GENE", "pos": [32, 38]}, {"entity": "IL - 10", "entity_type": "GENE", "pos": [42, 49]}], "task": "NER"}
{"text": "With six reports in the literature that show there is an order to melanoma nodal metastases and that the SLN histology is reflective of the histology of the remainder of the nodal basin , the more conservative SLN biopsy can be performed to adequately stage nodally the patient with melanoma .", "entity": [], "task": "NER"}
{"text": "In addition , a double mutant ( E482A , D489A ) which removed negative charges along one side of the helix had negligible effects on fusion activity .", "entity": [], "task": "NER"}
{"text": "Escherichia coli cells expressing a mutant glyV ( glycine tRNA ) gene have a UVM - constitutive phenotype : implications for mechanisms underlying the mutA or mutC mutator effect .", "entity": [{"entity": "mutant glyV", "entity_type": "GENE", "pos": [36, 47]}, {"entity": "glycine tRNA", "entity_type": "GENE", "pos": [50, 62]}, {"entity": "mutA", "entity_type": "GENE", "pos": [151, 155]}, {"entity": "mutC mutator", "entity_type": "GENE", "pos": [159, 171]}], "task": "NER"}
{"text": "Titres of antistreptolysin O in mothers of children affected with Down ' s syndrome .", "entity": [{"entity": "antistreptolysin O", "entity_type": "GENE", "pos": [10, 28]}], "task": "NER"}
{"text": "Synthetic studies on furan derivatives by the wittig reaction", "entity": [], "task": "NER"}
{"text": "Positive linear correlations were found when the AUC ( 0 - 12 ) ( r = 0 . 68 ; P less than 0 . 01 ) , the maximum plasma concentration ( r = 0 . 34 ; P less than 0 . 01 ) , the minimum plasma concentration ( r = 0 . 55 ; P less than 0 . 01 ) , and the elimination t1 / 2 ( r = 0 . 46 ; P less than 0 . 01 ) were regressed with age .", "entity": [], "task": "NER"}
{"text": "Furthermore , the social learning theory of depression , developed by Lewinsohn , is described .", "entity": [], "task": "NER"}
{"text": "Intramolecular interaction is believed to result in the formation of MxA monomers , whereas intermolecular interaction may induce the formation of large MxA oligomers .", "entity": [{"entity": "MxA monomers", "entity_type": "GENE", "pos": [69, 81]}, {"entity": "large MxA oligomers", "entity_type": "GENE", "pos": [147, 166]}], "task": "NER"}
{"text": "Analysis of a Het - mutation in Anabaena sp . strain PCC 7120 implicates a secondary metabolite in the regulation of heterocyst spacing .", "entity": [{"entity": "Het", "entity_type": "GENE", "pos": [14, 17]}], "task": "NER"}
{"text": "He presented with left lower abdominal pain and hematoma after a fall .", "entity": [], "task": "NER"}
{"text": "To this end we generated a detailed physical map of the genomic region spanning between sequence - tagged site markers D16S518 and D16S516 .", "entity": [{"entity": "D16S518", "entity_type": "GENE", "pos": [119, 126]}, {"entity": "D16S516", "entity_type": "GENE", "pos": [131, 138]}], "task": "NER"}
{"text": "The kinetics of erythromycin ( E . ) was studied in 16 patients with different degrees of impairment of renal function after a single intravenous dose .", "entity": [], "task": "NER"}
{"text": "Lasting paraplegia caused by loss of lumbar spinal cord interneurons in rats : no direct correlation with motor neuron loss .", "entity": [], "task": "NER"}
{"text": "Gold flaxseed ( whole or ground ) fed at levels of 5 or 15 % were compared to a 1 . 5 % menhaden oil or a typical control layer ration .", "entity": [], "task": "NER"}
{"text": "The study drugs ( combination vinblastine - CCNU and single - agent triazinate or dactinomycin ) failed to provide any meaningful antitumor activity for these patients with advanced renal cell cancer .", "entity": [], "task": "NER"}
{"text": "Some CHOP - C / EBP heterodimers apparently bind to alternative DNA sequence and thereby regulate the transcription of other genes .", "entity": [{"entity": "CHOP", "entity_type": "GENE", "pos": [5, 9]}, {"entity": "C / EBP", "entity_type": "GENE", "pos": [12, 19]}], "task": "NER"}
{"text": "Furthermore , addition of the recombinant NF - YA subunit restores NF - Y binding .", "entity": [{"entity": "recombinant NF - YA subunit", "entity_type": "GENE", "pos": [30, 57]}, {"entity": "NF - Y", "entity_type": "GENE", "pos": [67, 73]}], "task": "NER"}
{"text": "Our data provide the first evidence that differential splicing in the extracellular region of a receptor gene generates receptor variants with different ligand - binding specificities .", "entity": [], "task": "NER"}
{"text": "Intrathecal injections of small volumes of the alpha 2 - adrenoceptor agonists , xylazine and clonidine , into the cervical region of the spinal cord of conscious unrestrained sheep produced a dose - dependent analgesia of the forelimbs as measured using a mechanical pressure device .", "entity": [{"entity": "alpha 2 - adrenoceptor", "entity_type": "GENE", "pos": [47, 69]}], "task": "NER"}
{"text": "The specificity of the transcriptional activation by ISGF3 is mediated by specific elements termed IFN - stimulatory response element ( ISRE ) located in the promoter region of IFN - inducible genes .", "entity": [{"entity": "ISGF3", "entity_type": "GENE", "pos": [53, 58]}, {"entity": "IFN - stimulatory response element", "entity_type": "GENE", "pos": [99, 133]}, {"entity": "ISRE", "entity_type": "GENE", "pos": [136, 140]}, {"entity": "IFN", "entity_type": "GENE", "pos": [177, 180]}], "task": "NER"}
{"text": "Clinical development of interleukin - 10 .", "entity": [{"entity": "interleukin - 10", "entity_type": "GENE", "pos": [24, 40]}], "task": "NER"}
{"text": "Estrogen has positive effects on mood , sexual function , target end organs and cognitive function , and may play an important role in the etiology of Alzheimer ' s Disease by acting to prevent amyloid plaque formation , oxidative stress , or deterioration of the cholinergic neurotransmitter system .", "entity": [], "task": "NER"}
{"text": "The system consists of a microcomputer and six laboratory analyzers : a blood gas analyzer , a flame photometer , a plasma osmotic pressure meter , a chloride ion titrator , a blood sugar analyzer , and a hemoglobin concentration and saturation meter .", "entity": [{"entity": "hemoglobin", "entity_type": "GENE", "pos": [205, 215]}], "task": "NER"}
{"text": "Of these , 23 ( 13 . 6 % ) were due to GIB ( Upper GIB = 19 , Lower GIB = 4 ) .", "entity": [], "task": "NER"}
{"text": "Hence the GAP1 gene encodes a protein with characteristics typical of integral membrane proteins translocating ligants across cellular membranes .", "entity": [{"entity": "GAP1 gene", "entity_type": "GENE", "pos": [10, 19]}], "task": "NER"}
{"text": "Soluble fibrin monomer complexes in thromboembolism", "entity": [{"entity": "fibrin", "entity_type": "GENE", "pos": [8, 14]}], "task": "NER"}
{"text": "S16 , 16 . 8 % , P = 0 . 001 ) .", "entity": [], "task": "NER"}
{"text": "Microenvironments dominated by cyanobacteria ( BPC ) had a higher pH ( pH 7 - 8 ) than those dominated by lichen ( LTL ) ( pH 4 . 5 - 5 . 5 ) .", "entity": [], "task": "NER"}
{"text": "Saturated fatty acids induce a 1 . 6 - fold increase in transcription activity , whereas a large family of unsaturated fatty acids repress OLE1 transcription as much as 60 - fold .", "entity": [{"entity": "OLE1", "entity_type": "GENE", "pos": [139, 143]}], "task": "NER"}
{"text": "A third GEF , GRP3 ( KIAA0846 ) , activated both Ras and Rap1 and shared significant sequence homology with the calcium - and diacylglycerol - activated GEFs , GRP1 and GRP2 .", "entity": [{"entity": "GEF", "entity_type": "GENE", "pos": [8, 11]}, {"entity": "GRP3", "entity_type": "GENE", "pos": [14, 18]}, {"entity": "KIAA0846", "entity_type": "GENE", "pos": [21, 29]}, {"entity": "Ras", "entity_type": "GENE", "pos": [49, 52]}, {"entity": "Rap1", "entity_type": "GENE", "pos": [57, 61]}, {"entity": "GEFs", "entity_type": "GENE", "pos": [153, 157]}, {"entity": "GRP1", "entity_type": "GENE", "pos": [160, 164]}, {"entity": "GRP2", "entity_type": "GENE", "pos": [169, 173]}], "task": "NER"}
{"text": "We have determined the molecular organization and transcription start points ( tsp ) for the murine gene ( TK ) encoding thymidine kinase .", "entity": [{"entity": "TK", "entity_type": "GENE", "pos": [107, 109]}, {"entity": "thymidine kinase", "entity_type": "GENE", "pos": [121, 137]}], "task": "NER"}
{"text": "Effect of gentamycin on the kidney functional state in experimental pyelonephritis", "entity": [], "task": "NER"}
{"text": "The time - dependent changes in measured facility of outflow or \" washout phenomenon \" appeared to result from the gradual dissolution of the hyaluronidase - sensitive component of the barriers to aqueous outflow in the canine eye .", "entity": [{"entity": "hyaluronidase", "entity_type": "GENE", "pos": [142, 155]}], "task": "NER"}
{"text": "Melioidosis in Sika deer ( Cervus nippon nippon ) .", "entity": [], "task": "NER"}
{"text": "Many human malignant cells lack methylthioadenosine phosphorylase ( MTAP ) enzyme activity .", "entity": [{"entity": "methylthioadenosine phosphorylase", "entity_type": "GENE", "pos": [32, 65]}, {"entity": "MTAP", "entity_type": "GENE", "pos": [68, 72]}], "task": "NER"}
{"text": "Nucleocapsid structure and thermostability of the virion , nucleocapsid and polymerase complex .", "entity": [], "task": "NER"}
{"text": "We propose 2 separate PAI - 1 inductory pathways for PMA and IL - 1alpha in HepG2 , both involving protein tyrosine kinase activation ; the serum - induced signaling pathway may ( partially ) overlap with the PMA - activated protein kinase C / mitogen - activated protein kinase kinase pathway , leading to c - Jun homodimer binding to the PAI - 1 TRE .", "entity": [{"entity": "PAI - 1", "entity_type": "GENE", "pos": [22, 29]}, {"entity": "IL - 1alpha", "entity_type": "GENE", "pos": [61, 72]}, {"entity": "protein tyrosine kinase", "entity_type": "GENE", "pos": [99, 122]}, {"entity": "protein kinase C", "entity_type": "GENE", "pos": [225, 241]}, {"entity": "mitogen - activated protein kinase kinase", "entity_type": "GENE", "pos": [244, 285]}, {"entity": "c - Jun homodimer", "entity_type": "GENE", "pos": [307, 324]}, {"entity": "PAI - 1", "entity_type": "GENE", "pos": [340, 347]}], "task": "NER"}
{"text": "Crude drugs from aquatic plants .", "entity": [], "task": "NER"}
{"text": "Recurrence of the hepatic cyst after partial excision and drainage was complicated by fistula formation between the cyst and the duodenum .", "entity": [], "task": "NER"}
{"text": "These data show that tyrosine phosphorylation by FES affects the interaction of BCR with multiple signaling partners and suggest a general role for BCR in non - receptor protein - tyrosine kinase regulation and signal transduction .", "entity": [{"entity": "FES", "entity_type": "GENE", "pos": [49, 52]}, {"entity": "BCR", "entity_type": "GENE", "pos": [80, 83]}, {"entity": "BCR", "entity_type": "GENE", "pos": [148, 151]}, {"entity": "protein - tyrosine kinase", "entity_type": "GENE", "pos": [170, 195]}], "task": "NER"}
{"text": "Reversal of ' refractory septic shock ' by infusion of amrinone and angiotensin II in an anthracycline - treated patient .", "entity": [{"entity": "angiotensin II", "entity_type": "GENE", "pos": [68, 82]}], "task": "NER"}
{"text": "Replication regions from plant - pathogenic Pseudomonas syringae plasmids are similar to ColE2 - related replicons .", "entity": [], "task": "NER"}
{"text": "Comparison of dose volume histograms revealed that the 6 - field plan spared relatively more heart whereas the 8 - field plan spared relatively more lung .", "entity": [], "task": "NER"}
{"text": "STUDY OBJECTIVE : to characterize gas exchange and cardiopulmonary performance during maximal progressive arm crank exercise .", "entity": [], "task": "NER"}
{"text": "At 9 months postpartum , serum fT4 and fT3 levels were low normal ( 8 . 0 and 1 . 7 pmol / L , respectively ) , but TSH was not raised ( 0 . 4 mU / L ) .", "entity": [{"entity": "TSH", "entity_type": "GENE", "pos": [116, 119]}], "task": "NER"}
{"text": "The most frequent abnormality was GH deficiency ( six cases ) , followed by gonadotropin ( four cases ) , cortisol ( four cases ) , and TSH ( one case ) , whereas four patients showed high serum PRL values .", "entity": [{"entity": "GH", "entity_type": "GENE", "pos": [34, 36]}, {"entity": "gonadotropin", "entity_type": "GENE", "pos": [76, 88]}, {"entity": "TSH", "entity_type": "GENE", "pos": [136, 139]}, {"entity": "serum PRL", "entity_type": "GENE", "pos": [189, 198]}], "task": "NER"}
{"text": "In the normal controls the plasma FPA level ( mean + / - SD ) was 1 . 43 + / - 0 . 46 ng / ml .", "entity": [{"entity": "plasma FPA", "entity_type": "GENE", "pos": [27, 37]}], "task": "NER"}
{"text": "The nramp2 gene is comprised of 17 exons and spans more than 36 kb .", "entity": [{"entity": "nramp2 gene", "entity_type": "GENE", "pos": [4, 15]}], "task": "NER"}
{"text": "Studies on recurrences in gingival hyperplasia", "entity": [], "task": "NER"}
{"text": "BACKGROUND : In lung protective strategy , positive end - expiratory pressure ( PEEP ) slightly higher than the Pflex ( the airway pressure corresponding to the lower inflection point ( LIP ) on the inspiratory pressure - volume ( P - V ) curve measured with ZEEP ) is generally recommended .", "entity": [], "task": "NER"}
{"text": "Effect of a constant magnetic field on different models of carcinogenesis", "entity": [], "task": "NER"}
{"text": "FACS analysis demonstrated that MCs had reached middle to late G1 phase of cell cycle progression at this timepoint .", "entity": [], "task": "NER"}
{"text": "Nuclear export of proteins in plants : AtXPO1 is the export receptor for leucine - rich nuclear export signals in Arabidopsis thaliana .", "entity": [{"entity": "AtXPO1", "entity_type": "GENE", "pos": [39, 45]}], "task": "NER"}
{"text": "Strains carrying a snf1 mutation are unable to grow on sucrose , galactose , maltose , melibiose , or nonfermentable carbon sources ; utilization of these carbon sources is regulated by glucose repression .", "entity": [{"entity": "snf1 mutation", "entity_type": "GENE", "pos": [19, 32]}], "task": "NER"}
{"text": "Similarly , beta adrenoceptors blockade has been shown to be of value in achieving continence in a small group of patients .", "entity": [{"entity": "beta adrenoceptors", "entity_type": "GENE", "pos": [12, 30]}], "task": "NER"}
{"text": "The contractile effects of oxytocin , prostaglandin F2 alpha and their combined use on human pregnant myometrium were studied in vitro .", "entity": [{"entity": "oxytocin", "entity_type": "GENE", "pos": [27, 35]}], "task": "NER"}
{"text": "Effectively , the upstream , housekeeping - type promoter responds to FIXK and positively regulates the downstream , sigma 54 - type promoter .", "entity": [{"entity": "FIXK", "entity_type": "GENE", "pos": [70, 74]}, {"entity": "sigma 54 - type promoter", "entity_type": "GENE", "pos": [117, 141]}], "task": "NER"}
{"text": "Km values of the uncoupled enzymes IIGlc for glucose ranged from 0 . 5 to 2 . 5 mM , 2 orders of magnitude higher than the value of normal IIGlc .", "entity": [{"entity": "IIGlc", "entity_type": "GENE", "pos": [35, 40]}, {"entity": "IIGlc", "entity_type": "GENE", "pos": [139, 144]}], "task": "NER"}
{"text": "Measurement of protein in natural rubber latex .", "entity": [], "task": "NER"}
{"text": "Disruption of PML subnuclear domains by the acidic IE1 protein of human cytomegalovirus is mediated through interaction with PML and may modulate a RING finger - dependent cryptic transactivator function of PML .", "entity": [{"entity": "PML subnuclear domains", "entity_type": "GENE", "pos": [14, 36]}, {"entity": "acidic IE1 protein", "entity_type": "GENE", "pos": [44, 62]}, {"entity": "PML", "entity_type": "GENE", "pos": [125, 128]}, {"entity": "PML", "entity_type": "GENE", "pos": [207, 210]}], "task": "NER"}
{"text": "The fate of ochratoxin A during malting and brewing .", "entity": [], "task": "NER"}
{"text": "To further investigate the role of PKR in transcriptional signaling , we expressed the wild type human PKR and a catalytically inactive dominant negative PKR mutant in the murine pre - B lymphoma 70Z / 3 cells .", "entity": [{"entity": "PKR", "entity_type": "GENE", "pos": [35, 38]}, {"entity": "wild type human PKR", "entity_type": "GENE", "pos": [87, 106]}, {"entity": "PKR mutant", "entity_type": "GENE", "pos": [154, 164]}], "task": "NER"}
{"text": "Consistent with other experiments with these compounds , cocaine was the most potent of the group .", "entity": [], "task": "NER"}
{"text": "Atrial dissociation .", "entity": [], "task": "NER"}
{"text": "It is envisaged that the WHOQOL - BREF will be most useful in studies that require a brief assessment of quality of life , for example , in large epidemiological studies and clinical trials where quality of life is of interest .", "entity": [], "task": "NER"}
{"text": "Hepatitis B immune globulins and HIV antibodies .", "entity": [{"entity": "Hepatitis B immune globulins", "entity_type": "GENE", "pos": [0, 28]}, {"entity": "HIV antibodies", "entity_type": "GENE", "pos": [33, 47]}], "task": "NER"}
{"text": "One cytoplasmic target which reflects the functional state of the plastids is protein kinase C .", "entity": [{"entity": "protein kinase C", "entity_type": "GENE", "pos": [78, 94]}], "task": "NER"}
{"text": "A 360 - bp DNA fragment located over 500 bp upstream from the cfl transcriptional start site was used in DNase I protection assays to define the specific bases bound by CorR .", "entity": [{"entity": "cfl", "entity_type": "GENE", "pos": [62, 65]}, {"entity": "DNase I", "entity_type": "GENE", "pos": [105, 112]}, {"entity": "CorR", "entity_type": "GENE", "pos": [169, 173]}], "task": "NER"}
{"text": "A relationship between the immunological changes and the disease stage was discovered : the index of the 3H - thymidine incorporation was found to be 67 . 9 at the stage of disease exacerbation , and 208 . 8 at the stage of remission ; the complement titre reached , respectively , 46 . 64 + / - 5 . 28 and 112 . 0 + / - 6 . 0 units per ml .", "entity": [], "task": "NER"}
{"text": "In the spontaneous abortion group , the levels of PAPP - A were significantly lower than in normal pregnancy but higher than in non - pregnant controls .", "entity": [{"entity": "PAPP - A", "entity_type": "GENE", "pos": [50, 58]}], "task": "NER"}
{"text": "Maximum likelihood estimation in covariance structure analysis with truncated data .", "entity": [], "task": "NER"}
{"text": "The gene encoding rat peptidylglycine alpha - amidating monooxygenase ( PAM ) contains 26 protein - coding exons .", "entity": [{"entity": "peptidylglycine alpha - amidating monooxygenase", "entity_type": "GENE", "pos": [22, 69]}, {"entity": "PAM", "entity_type": "GENE", "pos": [72, 75]}], "task": "NER"}
{"text": "Whether this lack of preferential repair has to be explained by a defect in repair or in general transcription is unclear at present .", "entity": [], "task": "NER"}
{"text": "Pretreatment of human skin with tRA inhibited UV induction of c - Jun protein and , consequently , AP - 1 . c - Jun protein inhibition occurred via a posttranscriptional mechanism , since tRA did not inhibit UV induction of c - Jun mRNA .", "entity": [{"entity": "c - Jun protein", "entity_type": "GENE", "pos": [62, 77]}, {"entity": "AP - 1", "entity_type": "GENE", "pos": [99, 105]}, {"entity": "c - Jun protein", "entity_type": "GENE", "pos": [108, 123]}, {"entity": "c - Jun mRNA", "entity_type": "GENE", "pos": [224, 236]}], "task": "NER"}
{"text": "MUS81 encodes a novel helix - hairpin - helix protein involved in the response to UV - and methylation - induced DNA damage in Saccharomyces cerevisiae .", "entity": [{"entity": "MUS81", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "helix - hairpin - helix protein", "entity_type": "GENE", "pos": [22, 53]}], "task": "NER"}
{"text": "All possessed cutaneous receptive fields on the distal segments of digits 2 , 3 , or 4 .", "entity": [], "task": "NER"}
{"text": "In situ hybridization reveals strong signals for Zep mRNA in the cerebellum and olfactory bulb with moderate signals detected in the hippocampus and cortex .", "entity": [{"entity": "Zep mRNA", "entity_type": "GENE", "pos": [49, 57]}], "task": "NER"}
{"text": "A series of sequence fragments were placed 5 ' to the chloramphenicol acetyltransferase ( CAT ) reporter gene and ability to mediate transcription of CAT in response to IFN gamma or LPS treatment was studied following transient transfection in the macrophage - like cell line RAW 264 . 7 .", "entity": [{"entity": "chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [54, 87]}, {"entity": "CAT", "entity_type": "GENE", "pos": [90, 93]}, {"entity": "CAT", "entity_type": "GENE", "pos": [150, 153]}, {"entity": "IFN gamma", "entity_type": "GENE", "pos": [169, 178]}], "task": "NER"}
{"text": "A GT - rich sequence binding the transcription factor Sp1 is crucial for high expression of the human type VII collagen gene ( COL7A1 ) in fibroblasts and keratinocytes .", "entity": [{"entity": "transcription factor Sp1", "entity_type": "GENE", "pos": [33, 57]}, {"entity": "human type VII collagen gene", "entity_type": "GENE", "pos": [96, 124]}, {"entity": "COL7A1", "entity_type": "GENE", "pos": [127, 133]}], "task": "NER"}
{"text": "Using in vivo genomic dimethyl sulfate and KMnO4 footprinting , we showed that the promoter region is differentially protected , depending upon which holoenzyme is bound .", "entity": [], "task": "NER"}
{"text": "We conclude that these cDNAs belong to a novel GST class hereby designated Kappa , with the rat GST subunit 13 gene designated rGSTK1 and the human gene being called hGSTK1 .", "entity": [{"entity": "GST", "entity_type": "GENE", "pos": [47, 50]}, {"entity": "rat GST subunit 13 gene", "entity_type": "GENE", "pos": [92, 115]}, {"entity": "rGSTK1", "entity_type": "GENE", "pos": [127, 133]}, {"entity": "hGSTK1", "entity_type": "GENE", "pos": [166, 172]}], "task": "NER"}
{"text": "At onset of first post - weaning estrus , sows received either an intravulval injection of 3 . 75 mg of prostaglandin analogue ( PGF ) or , served as a non - injected control ( CON ) .", "entity": [], "task": "NER"}
{"text": "Tbx6 maps to chromosome 7 and does not appear to be linked to any known mutation .", "entity": [{"entity": "Tbx6", "entity_type": "GENE", "pos": [0, 4]}], "task": "NER"}
{"text": "Before therapy was started , trabecular bone alterations could be observed which were typical for Paget ' s disease of bone as there were bulky trabeculare , increased remodelling surfaces and giant osteoclasts .", "entity": [], "task": "NER"}
{"text": "At 11 . 5 years of follow - up , 521 major coronary disease events had occurred , 261 fatal and 260 non - fatal .", "entity": [], "task": "NER"}
{"text": "However , additional studies on cell lines and whole animals are required to understand GnRH signaling in the context of other hormones during the reproductive cycle of mouse and human .", "entity": [{"entity": "GnRH", "entity_type": "GENE", "pos": [88, 92]}], "task": "NER"}
{"text": "Total meso - pore volume and surface area ranged from 0 . 004 - 0 . 08 cm3 g ( - 1 ) and from 0 . 33 - 6 . 9 m2 g ( - 1 ) respectively , accounting for up 33 % of the BET surface area .", "entity": [], "task": "NER"}
{"text": "Contraindications to adenosine and drug interactions are noted in this article .", "entity": [], "task": "NER"}
{"text": "The extent of the odontoblast process in human dentin .", "entity": [], "task": "NER"}
{"text": "On transfer from glucose , succinate , malate , or glycerol medium to citrate medium , the Cit + Escherichia coli strains showed a delay of 36 to 48 h before growth .", "entity": [], "task": "NER"}
{"text": "The index patient , a 10 - year - old boy , presents typical symptoms of OPD type I together with bowing of the long bones and abnormalities of the thorax and spinal column .", "entity": [], "task": "NER"}
{"text": "After enzymatic hydrolysis of the water soluble fraction , it is shown that 28 % is again extractable by DCM of which 57 % consists of unchanged SC4453 which is therefore the main partner of conjugated products .", "entity": [], "task": "NER"}
{"text": "Additionally , the members of this family display strong sequence homologies between their larger C - terminal effector binding / oligomerization domains .", "entity": [], "task": "NER"}
{"text": "Microalbuminuria : a marker of systemic disease .", "entity": [], "task": "NER"}
{"text": "Long - term ambulatory measurement of transcutaneous arterial CO2 pressure ( PCO2 ) offers an opportunity to test directly the co - occurrence of panic and hyperventilation under natural conditions .", "entity": [], "task": "NER"}
{"text": "An association was found between zafirlukast plasma concentrations and increases in PC8SRaw 10 h after treatment ( p = 0 . 001 ) .", "entity": [], "task": "NER"}
{"text": "Most interestingly , although the effector plasmid containing the ICP27 gene had little effect on its own , two different and marked effects depending on the target were observed when ICP27 was combined with ICP4 or ICP0 or both .", "entity": [{"entity": "ICP27 gene", "entity_type": "GENE", "pos": [66, 76]}, {"entity": "ICP27", "entity_type": "GENE", "pos": [184, 189]}, {"entity": "ICP4", "entity_type": "GENE", "pos": [208, 212]}, {"entity": "ICP0", "entity_type": "GENE", "pos": [216, 220]}], "task": "NER"}
{"text": "Water pair and three - body potential of spectroscopic quality from Ab initio calculations", "entity": [], "task": "NER"}
{"text": "Because the wa - 2 mutation was mapped previously to the vicinity of the EGF / TGF - alpha receptor ( EGFR ) gene on mouse chromosome 11 , we hypothesized that the wa - 2 phenotype might result from a defect in either the expression or activity of EGFR , or both .", "entity": [{"entity": "wa - 2 mutation", "entity_type": "GENE", "pos": [12, 27]}, {"entity": "EGF / TGF - alpha receptor", "entity_type": "GENE", "pos": [73, 99]}, {"entity": "EGFR", "entity_type": "GENE", "pos": [102, 106]}, {"entity": "wa - 2 phenotype", "entity_type": "GENE", "pos": [164, 180]}, {"entity": "EGFR", "entity_type": "GENE", "pos": [248, 252]}], "task": "NER"}
{"text": "4 ) Mutation of the three extracellular cysteine residues of GFKAR beta indicated that the two conserved cysteine residues ( C305 and C385 ) , located between two transmembrane segments , form a solvent - accessible disulfide bond .", "entity": [{"entity": "GFKAR beta", "entity_type": "GENE", "pos": [61, 71]}], "task": "NER"}
{"text": "R of the chest wall was maximum ( 35 . 6 cmH2O . L - 1 . sec - 1 + / - 2 . 2 SE ) at 0 . 2 Hz - 10 ml and decreased with increasing f and VT , although the VT effect diminished at the higher f .", "entity": [], "task": "NER"}
{"text": "Time dependence of frequency potentiation in the isolated guinea - pig ' s atrium .", "entity": [], "task": "NER"}
{"text": "Comparison of the predicted amino acid sequence with that of the Drosophila virilis gene shows that several blocks of amino acid sequence have been very highly conserved .", "entity": [{"entity": "Drosophila virilis gene", "entity_type": "GENE", "pos": [65, 88]}], "task": "NER"}
{"text": "The N - terminal exon1 had no homology at the amino acid level with NGFI - B , the mammalian homologue .", "entity": [{"entity": "NGFI - B", "entity_type": "GENE", "pos": [68, 76]}], "task": "NER"}
{"text": "Although RAD17 , RAD24 and MEC3 are not required for cell cycle arrest when S phase is inhibited by hydroxyurea ( HU ) , they do contribute to the viability of yeast cells grown in the presence of HU , possibly because they are required for the repair of HU - induced DNA damage .", "entity": [{"entity": "RAD17", "entity_type": "GENE", "pos": [9, 14]}, {"entity": "RAD24", "entity_type": "GENE", "pos": [17, 22]}, {"entity": "MEC3", "entity_type": "GENE", "pos": [27, 31]}], "task": "NER"}
{"text": "Single oblique - view mammography for periodic screening for breast cancer in women .", "entity": [], "task": "NER"}
{"text": "Conventional toxicological considerations suggest that the adverse health effects of any necessary increase in coal combustion effluents would be greatest per unit of coal in those areas which are most heavily populated and have the highest preexisting levels of the gas - aerosol complex .", "entity": [], "task": "NER"}
{"text": "The arterial blood pressure was measured by using bloody method in anesthizied animals .", "entity": [], "task": "NER"}
{"text": "Nicotinic receptor antagonists mecamylamine ( 0 . 5 and 1 mg / kg ) and hexamethonium ( 5 and 10 mg / kg ) reduced the response induced by nicotine ( 0 . 25 mg / kg ) .", "entity": [{"entity": "Nicotinic receptor", "entity_type": "GENE", "pos": [0, 18]}], "task": "NER"}
{"text": "The present work represents an attempt to develop a method for measuring relative blood flow in intestinal capillaries , by the use of sodium fluorescein ( Na - F ) as an indicator substance .", "entity": [], "task": "NER"}
{"text": "The matrix of the CBs contains the diagnostic protein p80 - coilin , which is colocalized with the U7 small nuclear ribonucleoprotein ( snRNP ) , whereas the attached and embedded B - snurposomes contain splicing snRNPs .", "entity": [{"entity": "p80", "entity_type": "GENE", "pos": [54, 57]}, {"entity": "coilin", "entity_type": "GENE", "pos": [60, 66]}, {"entity": "U7 small nuclear ribonucleoprotein", "entity_type": "GENE", "pos": [99, 133]}], "task": "NER"}
{"text": "Tritium concentrations in environmental water samples were found to be determined within an accuracy of 10 % by this method when Vi / Vf was 14 - 25 .", "entity": [], "task": "NER"}
{"text": "The results of this study suggest that in patients with syndrome X , myocardial ischemia frequently develops during daily life ; silent ischemia is an important component of this syndrome ; and increased oxygen demand in the presence of impaired coronary vasodilatory capacity is not the only cause of myocardial ischemia .", "entity": [], "task": "NER"}
{"text": "Two patients with Ewing ' s sarcoma relapsed ( 1 patient with both local and distant failure ) at 26 and 58 months and were again rendered disease - free with surgery , total body irradiation and further chemotherapy .", "entity": [], "task": "NER"}
{"text": "In this study , the subcellular location , domain structure , and biochemical function of metaxin were investigated .", "entity": [{"entity": "metaxin", "entity_type": "GENE", "pos": [90, 97]}], "task": "NER"}
{"text": "Long - term renal function in on - heart - beating donor kidney transplantation : a single - center experience .", "entity": [], "task": "NER"}
{"text": "When single - point mutation was introduced to each GC box , EBS , and GT box in PFP9a20 , at least 3 - fold less CAT activity was observed in CTLL - R8 cells .", "entity": [{"entity": "EBS", "entity_type": "GENE", "pos": [61, 64]}, {"entity": "PFP9a20", "entity_type": "GENE", "pos": [81, 88]}, {"entity": "CAT", "entity_type": "GENE", "pos": [114, 117]}], "task": "NER"}
{"text": "Thirty - three percent had elevated titers ( above 1 : 20 dilution ) .", "entity": [], "task": "NER"}
{"text": "There is , however , uncertainty as to how results obtained in recent experiments scale up to landscape and regional levels and generalize across ecosystem types and processes .", "entity": [], "task": "NER"}
{"text": "Chest X - P revealed an abnormal shadow in the left upper lobe .", "entity": [], "task": "NER"}
{"text": "Despite these high initial rates of transcription , of all the promoter constructs only LAT - LTR was able to remain transcriptionally active after the establishment of a latent state .", "entity": [{"entity": "LAT", "entity_type": "GENE", "pos": [88, 91]}], "task": "NER"}
{"text": "Unestablished quail myoblasts were infected with a retroviral vector encoding the oncogenic form of H - Ras in order to investigate the mechanism by which this oncoprotein interferes with terminal differentiation .", "entity": [{"entity": "H - Ras", "entity_type": "GENE", "pos": [100, 107]}], "task": "NER"}
{"text": "Exhaled NO was assessed by controlled - flow chemoluminescence after adjusting for trapped air and after generating pressure in the oral cavity that was sufficient to close the soft palate ( Eco Physics CLD 77 AM analyzer ) .", "entity": [], "task": "NER"}
{"text": "SATB1 interacted with CDP through its DNA - binding domain , as demonstrated by glutathione S - transferase ( GST ) pull - down assays .", "entity": [{"entity": "SATB1", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "CDP", "entity_type": "GENE", "pos": [22, 25]}, {"entity": "glutathione S - transferase", "entity_type": "GENE", "pos": [80, 107]}, {"entity": "GST", "entity_type": "GENE", "pos": [110, 113]}], "task": "NER"}
{"text": "Both the inactive domain II P68 mutant and the deletion mutant lacking aa 91 - 243 were less inhibitory to growth in yeast due to the reduced ability to phosphorylate initiation factor 2 alpha in vivo .", "entity": [{"entity": "domain II P68 mutant", "entity_type": "GENE", "pos": [18, 38]}, {"entity": "initiation factor 2 alpha", "entity_type": "GENE", "pos": [167, 192]}], "task": "NER"}
{"text": "Applying the experience mentioned above , 4 - META was used to bond a proprietary photocuring microfilled composite material to Class V cavities in freshly extracted human teeth .", "entity": [], "task": "NER"}
{"text": "As the mechanism of the intractability , cell function involved in the defense against infection was evaluated .", "entity": [], "task": "NER"}
{"text": "A Premenstrual Syndrome , the late luteal phase disorder of DSM - IIIR criteria , was identified in 6 % of the women .", "entity": [], "task": "NER"}
{"text": "After 5 - h thermal induction of cells carrying the runaway recombinant pBS1 , protein B2 constituted 40 % of the soluble protein fraction of the cells .", "entity": [{"entity": "protein B2", "entity_type": "GENE", "pos": [79, 89]}], "task": "NER"}
{"text": "These results indicate that patients with SS and evidence of exercise - induced ST - segment depression may have decreased myocardial oxygen supply due to low hemoglobin levels and increased myocardial oxygen demand ( elevated double products ) when compared to subjects with SS who do not have exercise - induced ST - segment depression .", "entity": [{"entity": "hemoglobin", "entity_type": "GENE", "pos": [159, 169]}], "task": "NER"}
{"text": "The highest concentration of respirable mineral fibres was found during the overhaul of a truck with asbestos insulation ; respirable fibre concentration reached the value of 5 f / cm3 , and total dust concentration - the value of about 80 mg / m3 .", "entity": [], "task": "NER"}
{"text": "Changes in the size and organisation of the brain in man and his ancestors .", "entity": [], "task": "NER"}
{"text": "Mechanisms of action of local anaesthetics .", "entity": [], "task": "NER"}
{"text": "Gastric secretory inhibition induced by three methyl analogs of prostaglandin E2 administered intragastrically to man .", "entity": [], "task": "NER"}
{"text": "By contrast , footprint II at position - 125 is common to both HeLa and GH3 cell extracts and overlies a 15 - base - pair sequence found in all members of the growth hormone gene family .", "entity": [{"entity": "growth hormone gene family", "entity_type": "GENE", "pos": [159, 185]}], "task": "NER"}
{"text": "DNA sequence of the UL6 to UL20 genes of infectious laryngotracheitis virus and characterization of the UL10 gene product as a nonglycosylated and nonessential virion protein .", "entity": [{"entity": "UL6", "entity_type": "GENE", "pos": [20, 23]}, {"entity": "UL20 genes", "entity_type": "GENE", "pos": [27, 37]}, {"entity": "UL10 gene product", "entity_type": "GENE", "pos": [104, 121]}], "task": "NER"}
{"text": "Unlike LANA1 , LANA2 does not elicit a serologic response from patients with KS , PEL , or CD as measured by Western blot hybridization .", "entity": [{"entity": "LANA1", "entity_type": "GENE", "pos": [7, 12]}, {"entity": "LANA2", "entity_type": "GENE", "pos": [15, 20]}], "task": "NER"}
{"text": "CD4 degradation mediated by Vpu does not require the ER chaperone calnexin and is dependent on an intact ubiquitin - conjugating system .", "entity": [{"entity": "CD4", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "Vpu", "entity_type": "GENE", "pos": [28, 31]}, {"entity": "calnexin", "entity_type": "GENE", "pos": [66, 74]}, {"entity": "ubiquitin", "entity_type": "GENE", "pos": [105, 114]}], "task": "NER"}
{"text": "A deletion analysis of the FAS1 promoter lacking the previously characterized inositol / choline - responsive - element motif defined a region ( nucleotides - 760 to - 850 ) responsible for most of the remaining activation potency .", "entity": [{"entity": "FAS1 promoter", "entity_type": "GENE", "pos": [27, 40]}], "task": "NER"}
{"text": "Promoter constructs containing mutations in the PTRE sequence that selectively abolished the binding of either one or both complexes exerted opposite effects on the transcriptional activity of trypsin promoters in A . gambiae and Aedes aegypti cell lines .", "entity": [{"entity": "PTRE sequence", "entity_type": "GENE", "pos": [48, 61]}, {"entity": "trypsin promoters", "entity_type": "GENE", "pos": [193, 210]}], "task": "NER"}
{"text": "This preliminary study reports an initial evaluation of HMPAO - SPECT imaging for assessing regional alterations in brain function during opiate dependence and withdrawal .", "entity": [], "task": "NER"}
{"text": "The revaluation at the end of the study showed a good compliance for the proposed diet scheme by children , but a poor compliance by their families .", "entity": [], "task": "NER"}
{"text": "Cytostatic activity of some essential oils against HEp - 2 cells .", "entity": [], "task": "NER"}
{"text": "Custom - made orthoses play an invaluable role in achieving a wide range of therapeutic goals : improving function and pinch , stabilizing individual joints , preventing positional contractures , protecting joints from trauma , stretching the intrinsic muscles , correcting joint - and soft - tissue contractures , and controlling inflammation .", "entity": [], "task": "NER"}
{"text": "Excess recombinant PTB squelches the splicing switch and reestablishes exon skipping as the predominant splicing pathway .", "entity": [{"entity": "recombinant PTB", "entity_type": "GENE", "pos": [7, 22]}], "task": "NER"}
{"text": "Among women , plasma factor VII : Ag was inversely associated with income .", "entity": [{"entity": "plasma factor VII", "entity_type": "GENE", "pos": [14, 31]}], "task": "NER"}
{"text": "We concluded that these results support the feasibility and usefulness of N - of - 1 RCT in rheumatology practice .", "entity": [], "task": "NER"}
{"text": "K562 erythroleukemia cells stably transfected with constructs containing the human Agamma - globin promoter linked to an enhanced green fluorescent protein ( EGFP ) reporter , with or without HS2 , were analyzed for EGFP expression by flow cytometry .", "entity": [{"entity": "human Agamma - globin promoter", "entity_type": "GENE", "pos": [77, 107]}, {"entity": "enhanced green fluorescent protein", "entity_type": "GENE", "pos": [121, 155]}, {"entity": "EGFP", "entity_type": "GENE", "pos": [158, 162]}, {"entity": "EGFP", "entity_type": "GENE", "pos": [216, 220]}], "task": "NER"}
{"text": "Recently , we demonstrated that platelet - derived growth factor ( PDGF ) - beta receptor stimulation , but not various other growth factors , inhibits transcription of alpha1D - , but not alpha1A - or alpha1B - ARs , resulting in reduced norepinephrine - mediated SMC growth .", "entity": [{"entity": "platelet - derived growth factor ( PDGF ) - beta receptor", "entity_type": "GENE", "pos": [32, 89]}, {"entity": "alpha1D", "entity_type": "GENE", "pos": [169, 176]}, {"entity": "alpha1A", "entity_type": "GENE", "pos": [189, 196]}, {"entity": "alpha1B - ARs", "entity_type": "GENE", "pos": [202, 215]}], "task": "NER"}
{"text": "( A short account of Karl Touton ' s life is also included . ) After reviewing the historical development of the concept of giant cells and current interpretations of their nature , the unitarian view of polykaryons now favored by workers in the field is extended to include also the \" xanthelasmatic giant cell \" of Touton , whose characteristic appearance is determined merely by the presence of demonstrable lipid in the cytoplasm .", "entity": [], "task": "NER"}
{"text": "It has also been previously demonstrated that LPS treatment of splenic B cells from athymic mice results in a decrease in steady state mRNA encoding the A alpha class II protein .", "entity": [{"entity": "A alpha class II protein", "entity_type": "GENE", "pos": [153, 177]}], "task": "NER"}
{"text": "After birth , there was a significantly higher increase of IgA and IgM anti - M . leprae antibody activity in sera taken 3 - 6 months after birth from babies of Group 1 compared to Group 2 , but the IgA and IgM activity in sera taken after 6 months of age showed the same increase in the two groups .", "entity": [{"entity": "IgA", "entity_type": "GENE", "pos": [59, 62]}, {"entity": "IgM anti - M . leprae antibody", "entity_type": "GENE", "pos": [67, 97]}, {"entity": "IgA", "entity_type": "GENE", "pos": [199, 202]}, {"entity": "IgM", "entity_type": "GENE", "pos": [207, 210]}], "task": "NER"}
{"text": "Serum estriol levels during beta - receptor agonist infusion in the third trimester of pregnancy .", "entity": [{"entity": "beta - receptor", "entity_type": "GENE", "pos": [28, 43]}], "task": "NER"}
{"text": "These tiny premature infants also received PN for significantly longer periods of time , and the longer the infusions were administered the greater was the risk of cholestasis developing .", "entity": [], "task": "NER"}
{"text": "We show that sae1 - 1 and sae3 - 1 mutations each confer a distinct defect in meiotic recombination . sae1 - 1 produces recombinants but very slowly and ultimately to less than half the wild - type level ; sae3 - 1 makes persistent hyper - resected meiotic double - strand breaks and has a severe defect in formation of recombinants .", "entity": [{"entity": "sae1 - 1", "entity_type": "GENE", "pos": [13, 21]}, {"entity": "sae3 - 1 mutations", "entity_type": "GENE", "pos": [26, 44]}, {"entity": "sae1 - 1", "entity_type": "GENE", "pos": [102, 110]}, {"entity": "sae3 - 1", "entity_type": "GENE", "pos": [206, 214]}], "task": "NER"}
{"text": "Patients in the mucinous cyst group had significantly lower CA 125 cystic fluid levels compared with women with endometriomas and dermoids ( P & lt ; 0 . 05 ) .", "entity": [{"entity": "CA 125", "entity_type": "GENE", "pos": [60, 66]}], "task": "NER"}
{"text": "The brains were processed according to the tetramethylbenzidine ( TMB ) protocol of Mesulam ( ' 78 ) and studied with darkfield microscopy .", "entity": [], "task": "NER"}
{"text": "Analysis of WT1 target gene expression in stably transfected cell lines .", "entity": [{"entity": "WT1 target gene", "entity_type": "GENE", "pos": [12, 27]}], "task": "NER"}
{"text": "Some may affect the folding pathway or the affinity for chaperonins .", "entity": [{"entity": "chaperonins", "entity_type": "GENE", "pos": [56, 67]}], "task": "NER"}
{"text": "Amniotic fluid ionic concentration in response to chronic fetal vasopressin infusion .", "entity": [{"entity": "fetal vasopressin", "entity_type": "GENE", "pos": [58, 75]}], "task": "NER"}
{"text": "The use of bentonite in the compounding of hydrogels", "entity": [], "task": "NER"}
{"text": "VBP and a1 / EBP could mediate the high rates of ALV and RSV LTR - enhanced transcription in bursal lymphoma cells and many other cell types .", "entity": [{"entity": "VBP", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "a1 / EBP", "entity_type": "GENE", "pos": [8, 16]}, {"entity": "RSV LTR", "entity_type": "GENE", "pos": [57, 64]}], "task": "NER"}
{"text": "Insulin therapy has been expanded by development of human insulin and new modes of injection , including insulin pumps .", "entity": [{"entity": "Insulin", "entity_type": "GENE", "pos": [0, 7]}, {"entity": "human insulin", "entity_type": "GENE", "pos": [52, 65]}, {"entity": "insulin", "entity_type": "GENE", "pos": [105, 112]}], "task": "NER"}
{"text": "Also , anti - HIV gp120 and anti - CD4 crosslinking induced a 10 - 15 - fold increase in levels of both PI 3 - and PI 4 - kinase activity in anti - CD4 precipitates .", "entity": [{"entity": "anti - HIV gp120", "entity_type": "GENE", "pos": [7, 23]}, {"entity": "anti - CD4", "entity_type": "GENE", "pos": [28, 38]}, {"entity": "PI 3 - and PI 4 - kinase", "entity_type": "GENE", "pos": [104, 128]}, {"entity": "anti - CD4", "entity_type": "GENE", "pos": [141, 151]}], "task": "NER"}
{"text": "The genomic organization in this region is similar to the neural - restricted family members , Hel - N1 ( ELAVL2 ) and mHuD ( Elavl4 ) .", "entity": [{"entity": "Hel - N1", "entity_type": "GENE", "pos": [95, 103]}, {"entity": "ELAVL2", "entity_type": "GENE", "pos": [106, 112]}, {"entity": "mHuD", "entity_type": "GENE", "pos": [119, 123]}, {"entity": "Elavl4", "entity_type": "GENE", "pos": [126, 132]}], "task": "NER"}
{"text": "Chronic active hepatitis and pregnancy .", "entity": [], "task": "NER"}
{"text": "42nd annual meeting of the American Academy of Oral Pathology .", "entity": [], "task": "NER"}
{"text": "CONCLUSION : The biodistribution of 111In IgG is similar to that of 99mTc - HMPAO - labeled leukocytes .", "entity": [{"entity": "IgG", "entity_type": "GENE", "pos": [42, 45]}], "task": "NER"}
{"text": "In vitro DNA binding assays indicate that the elements identified can specifically interact with c - Ets - 1 protein .", "entity": [{"entity": "c - Ets - 1 protein", "entity_type": "GENE", "pos": [97, 116]}], "task": "NER"}
{"text": "The BCL - 6 POZ domain and other POZ domains interact with the co - repressors N - CoR and SMRT .", "entity": [{"entity": "BCL - 6", "entity_type": "GENE", "pos": [4, 11]}, {"entity": "N - CoR", "entity_type": "GENE", "pos": [79, 86]}, {"entity": "SMRT", "entity_type": "GENE", "pos": [91, 95]}], "task": "NER"}
{"text": "Since it is often necessary to resort to thoracotomy as a final step in making such a diagnosis , we have sought a procedure that is simpler while capable of providing the same information .", "entity": [], "task": "NER"}
{"text": "On the optic tentacle - gonadal axis in the control of the male - phase ovotestis in the slug ( Ariolimax californicus ) .", "entity": [], "task": "NER"}
{"text": "The protein kinase C inhibitor GF - 109203X abolished the activation by phorbol ester and inhibited the effect of CCK by 78 % but had no effect on EGF - activated MAPK activity .", "entity": [{"entity": "protein kinase C", "entity_type": "GENE", "pos": [4, 20]}, {"entity": "CCK", "entity_type": "GENE", "pos": [114, 117]}, {"entity": "EGF", "entity_type": "GENE", "pos": [147, 150]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [163, 167]}], "task": "NER"}
{"text": "Four multicannulated Holstein steers ( initial BW 424 + / - 16 kg ) were used in a 4 x 4 Latin square to determine the influence of protein supplementation on forage intake , site and extent of digestion , and nutrient flow in steers consuming dormant bluestem - range forage ( 2 . 3 % CP ) .", "entity": [], "task": "NER"}
{"text": "These morphological changes are associated with a marked induction of P450arom gene expression .", "entity": [{"entity": "P450arom gene", "entity_type": "GENE", "pos": [70, 83]}], "task": "NER"}
{"text": "This residue , although located 55 rather than 35 residues NH2 - terminal of the essential glutamate , is undoubtedly the analog of the second aspartate of the Asp - Asp - 35 - Glu motif found in other family members .", "entity": [], "task": "NER"}
{"text": "DNase I protection analysis as well as oligonucleotide competition experiments indicate that this binding is sequence specific .", "entity": [{"entity": "DNase I", "entity_type": "GENE", "pos": [0, 7]}], "task": "NER"}
{"text": "METHOD : After eligibility , patients were randomly allocated in one of the following groups : M = methylprednisolone 30 mg . kg - 1 over 1 hour , followed by 5 . 4 mg . kg - 1 . h - 1 for 23 hours , N = nimodipine 0 . 015 mg . kg - 1 . h - 1 over 2 hours followed by 0 . 03 mg . kg - 1 . h - 1 for 7 days , MN or P .", "entity": [], "task": "NER"}
{"text": "We have shown previously that EGF receptor activation stimulates gastrin gene expression through a GC - rich element called gERE .", "entity": [{"entity": "EGF receptor", "entity_type": "GENE", "pos": [30, 42]}, {"entity": "gastrin", "entity_type": "GENE", "pos": [65, 72]}], "task": "NER"}
{"text": "To determine cis - acting elements controlling the rat B - 50 / GAP - 43 gene expression , the genomic DNA encoding exon 1 and the 5 ' flanking sequence was isolated .", "entity": [{"entity": "B - 50", "entity_type": "GENE", "pos": [55, 61]}, {"entity": "GAP - 43", "entity_type": "GENE", "pos": [64, 72]}], "task": "NER"}
{"text": "The traW gene of the Escherichia coli K - 12 sex factor , F , encodes one of the numerous proteins required for conjugative transfer of this plasmid .", "entity": [{"entity": "traW gene of the Escherichia coli K - 12 sex factor", "entity_type": "GENE", "pos": [4, 55]}], "task": "NER"}
{"text": "Profilins IIa and IIb are also present in humans , suggesting that all mammals have three profilin isoforms .", "entity": [{"entity": "Profilins IIa and IIb", "entity_type": "GENE", "pos": [0, 21]}, {"entity": "profilin isoforms", "entity_type": "GENE", "pos": [90, 107]}], "task": "NER"}
{"text": "Results on the use of amiodarone in the prevention of paroxysmal AF have been equivocal ; this may be attributed to differences in defining paroxysmal AF .", "entity": [], "task": "NER"}
{"text": "Nuclear localization of this SNF2 - like putative helicase is dependent on a nuclear localization sequence located in the NH2 - terminal region .", "entity": [{"entity": "SNF2 - like", "entity_type": "GENE", "pos": [29, 40]}, {"entity": "helicase", "entity_type": "GENE", "pos": [50, 58]}], "task": "NER"}
{"text": "Expression of these chemokines is similar in that both require the NF - kappa B element and additional regions such as the CAAT / enhancer binding protein ( C / EBP ) element of the IL - 8 promoter .", "entity": [{"entity": "NF - kappa B element", "entity_type": "GENE", "pos": [67, 87]}, {"entity": "CAAT / enhancer binding protein", "entity_type": "GENE", "pos": [123, 154]}, {"entity": "C / EBP", "entity_type": "GENE", "pos": [157, 164]}, {"entity": "IL - 8 promoter", "entity_type": "GENE", "pos": [182, 197]}], "task": "NER"}
{"text": "Any opacity on a chest radiograph has a wide differential diagnosis .", "entity": [], "task": "NER"}
{"text": "Levels of p53 were substantially increased by E1A expression during adenovirus infection .", "entity": [{"entity": "p53", "entity_type": "GENE", "pos": [10, 13]}, {"entity": "E1A", "entity_type": "GENE", "pos": [46, 49]}], "task": "NER"}
{"text": "This pathway has been reported to mediate heterodimer interactions with the proapoptotic regulator , Bad .", "entity": [{"entity": "Bad", "entity_type": "GENE", "pos": [101, 104]}], "task": "NER"}
{"text": "The toxicity of copper to the collembolan Folsomia fimetaria L . was studied in soil incubated with copper sulfate for different periods before the introduction of collembolans , to assess the effect of aging of contamination on the toxicity of copper .", "entity": [], "task": "NER"}
{"text": "Earlier published data , indicating Sp1 binding to the R1 alpha / beta regions , could not be confirmed , suggesting that the R1 initiator element may function independent of Sp1 .", "entity": [{"entity": "Sp1", "entity_type": "GENE", "pos": [36, 39]}, {"entity": "R1 alpha / beta regions", "entity_type": "GENE", "pos": [55, 78]}, {"entity": "Sp1", "entity_type": "GENE", "pos": [175, 178]}], "task": "NER"}
{"text": "We sought to test whether a prolonged infusion of magnesium sulfate ( MgSO ( 4 ) ; 40 mmol / 24 hours ) would normalize QT interval variability in patients with compensated heart failure .", "entity": [], "task": "NER"}
{"text": "Using probes containing C / EBP - binding sites from the iNOS gene revealed further binding of different complexes , all of which were strongly inducible by cAMP and to a lower extent also by IL - 1beta .", "entity": [{"entity": "C / EBP - binding sites", "entity_type": "GENE", "pos": [24, 47]}, {"entity": "iNOS gene", "entity_type": "GENE", "pos": [57, 66]}, {"entity": "IL - 1beta", "entity_type": "GENE", "pos": [192, 202]}], "task": "NER"}
{"text": "Long - term follow - up of kidney donors : a longitudinal study .", "entity": [], "task": "NER"}
{"text": "Gore & Associates , Inc . ) standard wall graft segments varying in length from 4 to 12 cm .", "entity": [], "task": "NER"}
{"text": "This report describes the isolation and recombinant expression of a cDNA clone encoding HER4 , the fourth member of the human epidermal growth factor receptor ( EGFR ) family .", "entity": [{"entity": "HER4", "entity_type": "GENE", "pos": [88, 92]}, {"entity": "human epidermal growth factor receptor", "entity_type": "GENE", "pos": [120, 158]}, {"entity": "EGFR", "entity_type": "GENE", "pos": [161, 165]}], "task": "NER"}
{"text": "Precision of data from models of sodium kinetics in hemodialysis", "entity": [], "task": "NER"}
{"text": "Cytochrome bd biosynthesis in Escherichia coli : the sequences of the cydC and cydD genes suggest that they encode the components of an ABC membrane transporter .", "entity": [{"entity": "Cytochrome bd", "entity_type": "GENE", "pos": [0, 13]}, {"entity": "cydC", "entity_type": "GENE", "pos": [70, 74]}, {"entity": "cydD genes", "entity_type": "GENE", "pos": [79, 89]}, {"entity": "ABC membrane transporter", "entity_type": "GENE", "pos": [136, 160]}], "task": "NER"}
{"text": "We exposed Dorper - cross ewes at approximately 120 - 135 days of gestation to a hot ( 40 degrees C , 60 % relative humidity ) and a cold ( 4 degrees C , 90 % relative humidity ) environment and to treadmill exercise ( 2 . 1 km / h , 5 degrees gradient ) and measured fetal lamb and ewe body temperatures using previously implanted abdominal radiotelemeters .", "entity": [], "task": "NER"}
{"text": "Amino - terminal polymorphisms of the human beta 2 - adrenergic receptor impart distinct agonist - promoted regulatory properties .", "entity": [{"entity": "human beta 2 - adrenergic receptor", "entity_type": "GENE", "pos": [38, 72]}], "task": "NER"}
{"text": "A brief discussion for the relationship among these formulas is given .", "entity": [], "task": "NER"}
{"text": "The embryology of the vertebral column is reviewed briefly , and the origin of each anomaly of the C2 vertebra is traced to one of the two early stages in development as follows : 1 ) the formation of the mesenchymal vertebra or 2 ) its induction to cartilage .", "entity": [], "task": "NER"}
{"text": "Visualization of the cells by phase contrast microscopy indicated that murine PKCepsilon expression in the presence of glycerol resulted in a significant increase in the number of yeast cells exhibiting very small buds .", "entity": [{"entity": "murine PKCepsilon", "entity_type": "GENE", "pos": [71, 88]}], "task": "NER"}
{"text": "12 per cent was observed with the use of tetracycline and 4 - epianhydrotetracycline in doses of 1000 and 100gamma per embryo respectively .", "entity": [], "task": "NER"}
{"text": "The DNA - binding proteins are without effect on the transcription of plasmids lacking binding sites or when the binding sites are located further upstream .", "entity": [], "task": "NER"}
{"text": "The duration of PGE2 and PGF2 alpha elevations as well as the peak values were influenced by day of the cycle .", "entity": [], "task": "NER"}
{"text": "One hundred men who received alpha - tocopherol were matched on age , study center , and length of time between blood draws to 100 men who received a placebo .", "entity": [], "task": "NER"}
{"text": "Serum angiogenin concentrations in young patients with diabetes mellitus .", "entity": [{"entity": "Serum angiogenin", "entity_type": "GENE", "pos": [0, 16]}], "task": "NER"}
{"text": "Bodily referents and the experience of affect .", "entity": [], "task": "NER"}
{"text": "We studied about the histological findings of the kidneys including of the infiltrated macrophages in one hour post - transplantation kidney biopsies ( one hour biopsies ) and re - biopsies on 11 patients .", "entity": [], "task": "NER"}
{"text": "The human lbc oncogene product is a guanine nucleotide exchange factor that specifically activates the Rho small GTP binding protein , thus resulting in biologically active , GTP - bound Rho , which in turn mediates actin cytoskeletal reorganization , gene transcription , and entry into the mitotic S phase .", "entity": [{"entity": "human lbc oncogene product", "entity_type": "GENE", "pos": [4, 30]}, {"entity": "guanine nucleotide exchange factor", "entity_type": "GENE", "pos": [36, 70]}, {"entity": "Rho small GTP binding protein", "entity_type": "GENE", "pos": [103, 132]}, {"entity": "Rho", "entity_type": "GENE", "pos": [187, 190]}, {"entity": "actin", "entity_type": "GENE", "pos": [216, 221]}], "task": "NER"}
{"text": "RESULTS : There were no significant differences in the mean serum vitamin A , E concentrations and vitamin E / cholesterol ratio between pregnant women with normal hemoglobin and hemoglobinopathies , while confounding variables that might affect serum vitamin levels i . e . maternal age , gravida , BMI , gestational age , hematocrit , hemoglobin , mean corpuscular hemoglobin concentration and blood group were not different .", "entity": [{"entity": "hemoglobin", "entity_type": "GENE", "pos": [164, 174]}, {"entity": "hemoglobin", "entity_type": "GENE", "pos": [179, 189]}, {"entity": "hemoglobin", "entity_type": "GENE", "pos": [337, 347]}], "task": "NER"}
{"text": "These data indicate that SB 203580 sensitive p38 MAP kinases are not involved in okadaic acid mediated increases in TRE DNA binding and transactivation .", "entity": [{"entity": "p38 MAP kinases", "entity_type": "GENE", "pos": [45, 60]}], "task": "NER"}
{"text": "In contrast , group II showed a significant improvement in peak VO2 with rate adaptive AV delay compared to fixed AV delay programming ( P less than 0 . 05 ) .", "entity": [], "task": "NER"}
{"text": "This vector should be applicable for high - throughput characterization of new open reading frames found in genome sequencing .", "entity": [], "task": "NER"}
{"text": "Each patient was seen for 5 to 13 postsurgical maintenance visits .", "entity": [], "task": "NER"}
{"text": "Evidence for a role of Smad6 in chick cardiac development .", "entity": [{"entity": "Smad6", "entity_type": "GENE", "pos": [23, 28]}], "task": "NER"}
{"text": "The overall response rate including CR and PR was 23 . 5 % ( 4 / 17 ) .", "entity": [], "task": "NER"}
{"text": "Left ventricular responses to dopamine in dilated cardiomyopathy as assessed by two - dimensional echocardiography and compared with findings of thallium - 201 scintigraphy .", "entity": [], "task": "NER"}
{"text": "RESULTS : Lateral PF OA was more common than medial PF OA ( P < 0 . 0001 ) .", "entity": [], "task": "NER"}
{"text": "Moreover , we show that GATA - 1 and Sp1 synergize from a distance in constructs designed to mimic the architecture of globin locus control regions and downstream globin promoters .", "entity": [{"entity": "GATA - 1", "entity_type": "GENE", "pos": [24, 32]}, {"entity": "Sp1", "entity_type": "GENE", "pos": [37, 40]}, {"entity": "globin locus control regions", "entity_type": "GENE", "pos": [119, 147]}, {"entity": "globin promoters", "entity_type": "GENE", "pos": [163, 179]}], "task": "NER"}
{"text": "After 5 , 850 C14 BP , the decrease in Acer stands could be attributed to fire as suggested by the strong increase in Betula and by the delayed expansion of Pinus cembra .", "entity": [], "task": "NER"}
{"text": "4 . 7 + / - 0 . 6 micromol . kg - 1 . min - 1 ) but was not changed by training .", "entity": [], "task": "NER"}
{"text": "A wide conservation of iscSUA genes in nature and evidence that NifU and NifS participate in the mobilization of iron and sulfur for nitrogenase - specific iron - sulfur cluster formation suggest that the products of the iscSUA genes could play a general role in the formation or repair of iron - sulfur clusters .", "entity": [{"entity": "iscSUA genes", "entity_type": "GENE", "pos": [23, 35]}, {"entity": "NifU", "entity_type": "GENE", "pos": [64, 68]}, {"entity": "NifS", "entity_type": "GENE", "pos": [73, 77]}, {"entity": "nitrogenase", "entity_type": "GENE", "pos": [133, 144]}, {"entity": "iscSUA genes", "entity_type": "GENE", "pos": [221, 233]}], "task": "NER"}
{"text": "RET / PTC oncogenes , generated by chromosomal rearrangements in papillary thyroid carcinomas , are constitutively activated versions of proto - RET , a gene coding for a receptor - type tyrosine kinase ( TK ) whose ligand is still unknown .", "entity": [{"entity": "RET", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "PTC", "entity_type": "GENE", "pos": [6, 9]}, {"entity": "proto - RET", "entity_type": "GENE", "pos": [137, 148]}, {"entity": "receptor - type tyrosine kinase", "entity_type": "GENE", "pos": [171, 202]}, {"entity": "TK", "entity_type": "GENE", "pos": [205, 207]}], "task": "NER"}
{"text": "Diclofenac sodium : blood concentration of the slow - release form and influence on the metabolism of kallikrein .", "entity": [{"entity": "kallikrein", "entity_type": "GENE", "pos": [102, 112]}], "task": "NER"}
{"text": "The unc - 101 , sli - 1 , and rok - 1 genes encode a distinct set of negative regulators of vulval differentiation .", "entity": [{"entity": "unc - 101", "entity_type": "GENE", "pos": [4, 13]}, {"entity": "sli - 1", "entity_type": "GENE", "pos": [16, 23]}, {"entity": "rok - 1 genes", "entity_type": "GENE", "pos": [30, 43]}], "task": "NER"}
{"text": "Optimized USF and MYC DNA - binding sites , which differ in the nucleotides bordering the hexanucleotide box displace the E - C4 factor in competition assays but with lesser efficiency than the E - C4 site itself .", "entity": [{"entity": "USF", "entity_type": "GENE", "pos": [10, 13]}, {"entity": "MYC", "entity_type": "GENE", "pos": [18, 21]}, {"entity": "E - C4 factor", "entity_type": "GENE", "pos": [122, 135]}, {"entity": "E - C4 site", "entity_type": "GENE", "pos": [194, 205]}], "task": "NER"}
{"text": "Fluorescent in situ hybridization ( FISH ) analysis showed that the novel regions involved in the NFKB2 rearrangement originated from chromosome 7q34 , thus implying the occurrence of a t ( 7 ; 10 ) ( q34 ; q24 ) reciprocal chromosomal translocation .", "entity": [{"entity": "NFKB2", "entity_type": "GENE", "pos": [98, 103]}], "task": "NER"}
{"text": "DESIGN : Intradermally injected human squamous cell carcinoma cells were grown to 40 to 80 mm3 in athymic nude mice and irradiated with 675 - nm light ( 75 J / cm2 , 75 mW / cm2 ) 24 hours after the intraperitoneal injection of SiPc IV ( 1 . 0 mg / kg ) .", "entity": [], "task": "NER"}
{"text": "The effects of space radiation are partially known on astronauts , but much remains to be discovered .", "entity": [], "task": "NER"}
{"text": "First , the amino - terminal regulatory arm of the GDI binds to the switch I and II domains of Cdc42 leading to the inhibition of both GDP dissociation and GTP hydrolysis .", "entity": [{"entity": "GDI", "entity_type": "GENE", "pos": [51, 54]}, {"entity": "Cdc42", "entity_type": "GENE", "pos": [95, 100]}], "task": "NER"}
{"text": "There are two regulatory regions between the US3 and the US6 transcription units .", "entity": [{"entity": "US3", "entity_type": "GENE", "pos": [45, 48]}, {"entity": "US6 transcription units", "entity_type": "GENE", "pos": [57, 80]}], "task": "NER"}
{"text": "In the virus - infected cells , translation of the M1 protein was reduced to 10 to 20 % of that of the wild - type virus ; however , the translation of neither the nucleoprotein nor NS1 was significantly interfered with , indicating the important role of NS1 in translational stimulation of the M1 protein .", "entity": [{"entity": "M1 protein", "entity_type": "GENE", "pos": [51, 61]}, {"entity": "NS1", "entity_type": "GENE", "pos": [182, 185]}, {"entity": "NS1", "entity_type": "GENE", "pos": [255, 258]}, {"entity": "M1 protein", "entity_type": "GENE", "pos": [295, 305]}], "task": "NER"}
{"text": "Thus , the predicted M3 ORF is a functional gene that encodes an abundant secreted protein which is a candidate for interacting with host cellular receptors or cytokines .", "entity": [], "task": "NER"}
{"text": "There was a positive correlation between change from baseline in parietal lobe gray - matter cytosolic choline , expressed in terms of choline / creatine resonance ratios , and cognitive performance as measured with the Alzheimer ' s Disease Assessment Scale Cognitive Subscale .", "entity": [], "task": "NER"}
{"text": "The protein encoded by the NF2 gene has a similarity to ezrin , radixin and moesin ( ERM ) proteins that link membrane proteins to the cytoskeleton .", "entity": [{"entity": "NF2 gene", "entity_type": "GENE", "pos": [27, 35]}, {"entity": "ezrin", "entity_type": "GENE", "pos": [56, 61]}, {"entity": "radixin", "entity_type": "GENE", "pos": [64, 71]}, {"entity": "moesin", "entity_type": "GENE", "pos": [76, 82]}, {"entity": "ERM", "entity_type": "GENE", "pos": [85, 88]}], "task": "NER"}
{"text": "80 v - ets - encoded amino - acids located immediately after the v - myb / v - ets junction are not found in P54 / 56c - ets , the translation product of the c - ets proto - oncogene , nor in a set of cellular proteins of 64 , 62 , and 60 kDa related to but distinct from P54 / 56c - ets .", "entity": [{"entity": "v - ets", "entity_type": "GENE", "pos": [3, 10]}, {"entity": "v - myb", "entity_type": "GENE", "pos": [65, 72]}, {"entity": "v - ets", "entity_type": "GENE", "pos": [75, 82]}, {"entity": "P54", "entity_type": "GENE", "pos": [109, 112]}, {"entity": "56c - ets", "entity_type": "GENE", "pos": [115, 124]}, {"entity": "c - ets proto - oncogene", "entity_type": "GENE", "pos": [158, 182]}, {"entity": "P54", "entity_type": "GENE", "pos": [272, 275]}, {"entity": "56c - ets", "entity_type": "GENE", "pos": [278, 287]}], "task": "NER"}
{"text": "Secretogranin II ( SgII ) is a secretory polypeptide stored in large dense core vesicles of neuroendocrine and neuronal cells .", "entity": [{"entity": "Secretogranin II", "entity_type": "GENE", "pos": [0, 16]}, {"entity": "SgII", "entity_type": "GENE", "pos": [19, 23]}], "task": "NER"}
{"text": "In contrast translocation of G1 to the Golgi was not observed when G1 was coexpressed with NSm , although NSm itself was still detected in the Golgi .", "entity": [{"entity": "G1", "entity_type": "GENE", "pos": [29, 31]}, {"entity": "G1", "entity_type": "GENE", "pos": [67, 69]}, {"entity": "NSm", "entity_type": "GENE", "pos": [91, 94]}, {"entity": "NSm", "entity_type": "GENE", "pos": [106, 109]}], "task": "NER"}
{"text": "The results show that while a larger polypeptide substrate carrying the HD1 / 3C site was processed more efficiently than a polypeptide substrate carrying the POL / Zn site , cleavage of the synthetic peptide substrates containing these two cleavage sites occurred at similar efficiencies .", "entity": [{"entity": "HD1 / 3C site", "entity_type": "GENE", "pos": [72, 85]}, {"entity": "POL / Zn site", "entity_type": "GENE", "pos": [159, 172]}], "task": "NER"}
{"text": "GBF1 and GBF2 mRNA is present in light and dark grown leaves as well as in roots .", "entity": [{"entity": "GBF1", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "GBF2 mRNA", "entity_type": "GENE", "pos": [9, 18]}], "task": "NER"}
{"text": "In this technique , the posterior wall of the neopharynx consists only of the prevertebral tissue , while the flap forms the anterior and lateral walls .", "entity": [], "task": "NER"}
{"text": "These data may indicate redundancy between members of the NGFI - B / Nurr1 / Nor1 subfamily and could explain why no phenotypic disturbances have yet been found in mice in which the NGFI - B gene has been inactivated .", "entity": [{"entity": "NGFI - B", "entity_type": "GENE", "pos": [58, 66]}, {"entity": "Nurr1", "entity_type": "GENE", "pos": [69, 74]}, {"entity": "Nor1", "entity_type": "GENE", "pos": [77, 81]}, {"entity": "NGFI - B gene", "entity_type": "GENE", "pos": [182, 195]}], "task": "NER"}
{"text": "Activation of the mitogen - activated protein kinase ( MAPK ) pathway enhances long - range transactivation by the beta - globin locus control region ( LCR ) ( W .", "entity": [{"entity": "mitogen - activated protein kinase", "entity_type": "GENE", "pos": [18, 52]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [55, 59]}, {"entity": "beta - globin locus control region", "entity_type": "GENE", "pos": [115, 149]}], "task": "NER"}
{"text": "The gp41 peptide ( Glu - Leu - Asp - Lys - Trp - Ala ) fused to the C - terminus of Sj GST forms a loop stabilized by symmetry - related GSTs .", "entity": [{"entity": "gp41 peptide ( Glu - Leu - Asp - Lys - Trp - Ala )", "entity_type": "GENE", "pos": [4, 54]}, {"entity": "Sj GST", "entity_type": "GENE", "pos": [84, 90]}, {"entity": "GSTs", "entity_type": "GENE", "pos": [137, 141]}], "task": "NER"}
{"text": "The GST - CBL - LZIP fusion protein contains a binding site for the SH2 domain of the p85 subunit of phosphatidylinositol 3 - kinase , which mapped to Tyr731 , which is present in the sequence YEAM .", "entity": [{"entity": "GST", "entity_type": "GENE", "pos": [4, 7]}, {"entity": "CBL", "entity_type": "GENE", "pos": [10, 13]}, {"entity": "LZIP", "entity_type": "GENE", "pos": [16, 20]}, {"entity": "SH2 domain", "entity_type": "GENE", "pos": [68, 78]}, {"entity": "p85 subunit", "entity_type": "GENE", "pos": [86, 97]}, {"entity": "phosphatidylinositol 3 - kinase", "entity_type": "GENE", "pos": [101, 132]}], "task": "NER"}
{"text": "The testes of 8 specimens of Triturus marmoratus were collected during each month of 1987 and processed for electron microscopy and light microscopy demonstration of testosterone ( T ) following the ABC ( avidin - biotin peroxidase complex ) method .", "entity": [{"entity": "ABC", "entity_type": "GENE", "pos": [199, 202]}, {"entity": "avidin - biotin peroxidase complex", "entity_type": "GENE", "pos": [205, 239]}], "task": "NER"}
{"text": "We have generated transgenic fly strains with mutations affecting specific TRA - 2 isoforms to investigate their individual roles in regulating the alternative processing of doublesex , exuperantia and tra - 2 pre - mRNA .", "entity": [{"entity": "TRA - 2 isoforms", "entity_type": "GENE", "pos": [75, 91]}, {"entity": "doublesex", "entity_type": "GENE", "pos": [174, 183]}, {"entity": "exuperantia", "entity_type": "GENE", "pos": [186, 197]}, {"entity": "tra - 2 pre - mRNA", "entity_type": "GENE", "pos": [202, 220]}], "task": "NER"}
{"text": "Few triers or users had received SLT counseling from their dentist despite high dental utilization rates .", "entity": [], "task": "NER"}
{"text": "There has been no significant toxicity associated with repeated 5 - FU instillation into the airway .", "entity": [], "task": "NER"}
{"text": "He had complained of fever and right hypochondralgia 2 months after being operated for appendicitis .", "entity": [], "task": "NER"}
{"text": "Thus , apoptosis in hematopoietic cells is the end result of a conflict between death and survival signals , rather than a simple death by default .", "entity": [], "task": "NER"}
{"text": "Changes in testicular testosterone and acid and alkaline phosphatase activity in testis and accessory sex organs after induction of varicocele in Noble rats .", "entity": [{"entity": "alkaline phosphatase", "entity_type": "GENE", "pos": [48, 68]}], "task": "NER"}
{"text": "The reconstituted RNA polymerases containing the mutant alpha subunits were examined for their response to transcription activation by cAMP - CRP and the rrnBP1 UP element .", "entity": [{"entity": "RNA polymerases", "entity_type": "GENE", "pos": [18, 33]}, {"entity": "cAMP - CRP", "entity_type": "GENE", "pos": [135, 145]}, {"entity": "rrnBP1 UP element", "entity_type": "GENE", "pos": [154, 171]}], "task": "NER"}
{"text": "Changes in the greater omentum of mice of different strains after intraperitoneal immunization with sheep erythrocytes .", "entity": [], "task": "NER"}
{"text": "In patients , 750 mL of saline lowered DL ( CO ) ( - 8 % , P < 0 . 01 versus baseline ) , D ( M ) ( - 10 % , P < 0 . 01 versus baseline ) , aldosterone ( - 29 % , P < 0 . 01 versus baseline ) , renin ( - 52 % , P < 0 . 01 versus baseline ) , and hematocrit ( - 6 % , P < 0 . 05 versus baseline ) and increased V ( C ) ( 20 % , P < 0 . 01 versus baseline ) , without changing rap and wpp .", "entity": [{"entity": "renin", "entity_type": "GENE", "pos": [194, 199]}], "task": "NER"}
{"text": "Reversible pressure - induced amorphization in solid C70 : Raman and photoluminescence study .", "entity": [], "task": "NER"}
{"text": "Antibodies against REAP - 1 inhibit in vitro RNA editing reactions confirming its role in RNA editing .", "entity": [{"entity": "REAP - 1", "entity_type": "GENE", "pos": [19, 27]}], "task": "NER"}
{"text": "The more severe the CRF , the more likely that total HDL and HDL2 cholesterol will be low .", "entity": [{"entity": "HDL", "entity_type": "GENE", "pos": [53, 56]}, {"entity": "HDL2 cholesterol", "entity_type": "GENE", "pos": [61, 77]}], "task": "NER"}
{"text": "A conventional N - terminal signal sequence was not detected in the NodO protein .", "entity": [{"entity": "NodO protein", "entity_type": "GENE", "pos": [68, 80]}], "task": "NER"}
{"text": "Mean CD4 percentages were lower postpartum ( 21 . 9 + / - 3 . 4 ) than prepartum ( 45 . 1 + / - 6 . 7 ) in all five patients studied , although proliferative responses to the mitogens phytohemagglutinin and pokeweed were unchanged during the study period .", "entity": [{"entity": "CD4", "entity_type": "GENE", "pos": [5, 8]}, {"entity": "mitogens phytohemagglutinin and pokeweed", "entity_type": "GENE", "pos": [175, 215]}], "task": "NER"}
{"text": "Significance of the determination of vascular tonus in the differential diagnosis of rheumatic and arteriosclerotic lesions of the heart and vessels in middle - aged and elderly persons with fibrillation arrhythmia", "entity": [], "task": "NER"}
{"text": "The disease processes that affect transplant patients both before and after transplantation are not seen frequently in the general practice of gastroenterology .", "entity": [], "task": "NER"}
{"text": "In Experiment 2 , levels were : amprolium and ethopabate , . 02 % ; salinomycin , 55 mg / kg ; monensin , 99 mg / kg ; and lasalocid , 110 mg / kg .", "entity": [], "task": "NER"}
{"text": "This duplicated genomic region is also linked tightly to D1Z2 , a genetic marker containing a highly polymorphic VNTR ( variable number tandem repeat ) consisting of an unusual 40 - bp reiterated sequence .", "entity": [{"entity": "D1Z2", "entity_type": "GENE", "pos": [57, 61]}], "task": "NER"}
{"text": "The level of transcription generated by all of these activators is greater than the sum of the levels generated by individual factors , a phenomenon designated transcriptional synergy .", "entity": [], "task": "NER"}
{"text": "Aspartame is a synthetic sweetener commonly used in soft drinks and many foods .", "entity": [], "task": "NER"}
{"text": "Under control conditions and in the presence of 3 micromol / kg MIB and VER the maximal effect of noradrenaline was reached at 0 . 1 micromol / kg whereas in the presence of 10 micromol / kg MIB and VER it was reached at a dose of 1 micromol / kg .", "entity": [], "task": "NER"}
{"text": "The highly conserved region of U6 snRNA has a structural similarity with the catalytic domain of the negative strand of the satellite RNA of tobacco ring spot virus [ ( - ) sTRSV ] , suggesting that the highly conserved region of U6 snRNA forms the catalytic center .", "entity": [{"entity": "U6 snRNA", "entity_type": "GENE", "pos": [31, 39]}, {"entity": "U6 snRNA", "entity_type": "GENE", "pos": [230, 238]}], "task": "NER"}
{"text": "By computed homology search , we noticed significant similarities between US3 PK and p21 - activated kinase ( PAK ) , which is activated by the Cdc42 or Rac .", "entity": [{"entity": "US3 PK", "entity_type": "GENE", "pos": [74, 80]}, {"entity": "p21 - activated kinase", "entity_type": "GENE", "pos": [85, 107]}, {"entity": "PAK", "entity_type": "GENE", "pos": [110, 113]}, {"entity": "Cdc42", "entity_type": "GENE", "pos": [144, 149]}, {"entity": "Rac", "entity_type": "GENE", "pos": [153, 156]}], "task": "NER"}
{"text": "Using transgenic lines a detailed analysis of the Hoxa - 7 enhancer - directed expression during embryogenesis was performed . lacZ expression was first detected in the allantois at day 7 . 5 p . c . and in mesoderm and ectoderm at day 8 . 5 of gestation .", "entity": [{"entity": "Hoxa - 7", "entity_type": "GENE", "pos": [50, 58]}, {"entity": "lacZ", "entity_type": "GENE", "pos": [127, 131]}], "task": "NER"}
{"text": "Its phosphorylation strongly potentiates its ability to activate transcription of the c - fos promoter through a ternary complex assembled on the c - fos serum response element .", "entity": [{"entity": "c - fos promoter", "entity_type": "GENE", "pos": [86, 102]}, {"entity": "c - fos serum response element", "entity_type": "GENE", "pos": [146, 176]}], "task": "NER"}
{"text": "Drosophila melanogaster casein kinase II ( DmCKII ) is composed of catalytic ( alpha ) and regulatory ( beta ) subunits associated as an alpha2beta2 heterotetramer .", "entity": [{"entity": "Drosophila melanogaster casein kinase II", "entity_type": "GENE", "pos": [0, 40]}, {"entity": "DmCKII", "entity_type": "GENE", "pos": [43, 49]}], "task": "NER"}
{"text": "Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor .", "entity": [{"entity": "DNA topoisomerase II alpha gene", "entity_type": "GENE", "pos": [14, 45]}, {"entity": "p53 tumor suppressor", "entity_type": "GENE", "pos": [64, 84]}], "task": "NER"}
{"text": "These conditions may determine an increase in the level of indoor pollutants ( tobacco smoke , gases produced by cooling processes etc . ) and of allergens derived from mites , domestic animals and cockroaches .", "entity": [], "task": "NER"}
{"text": "Vav and Dbl are members of a novel class of oncogene proteins that share significant sequence identity in a approximately 250 - amino - acid domain , designated the Dbl homology domain .", "entity": [{"entity": "Vav", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "Dbl", "entity_type": "GENE", "pos": [8, 11]}, {"entity": "Dbl homology domain", "entity_type": "GENE", "pos": [165, 184]}], "task": "NER"}
{"text": "METHODS : Levels of sIL - 2R were measured simultaneously in plasma and pleural fluid in 111 patients with pleural effusions of unknown causes .", "entity": [{"entity": "sIL - 2R", "entity_type": "GENE", "pos": [20, 28]}], "task": "NER"}
{"text": "HCVR - L significantly increased dVAS / dPCO2 to 4 . 9 + / - 0 . 7 mm / Torr compared to HCVR - S ( p < 0 . 05 ) .", "entity": [], "task": "NER"}
{"text": "Right - sided hemiplegia of 5 years duration occurred in the remaining case .", "entity": [], "task": "NER"}
{"text": "Studies on the excretion of selenium in urine and feces and distribution in the organs of rats by a method of radioactivity measurement", "entity": [], "task": "NER"}
{"text": "The LIF appeared to be released by the patient ' s peripheral blood lymphocytes when cultured with optimal doses of propranolol .", "entity": [{"entity": "LIF", "entity_type": "GENE", "pos": [4, 7]}], "task": "NER"}
{"text": "In addition , the findings confirmed previous studies which showed that monkeys with total bilateral striatectomies could require the ability to execute accurate visually guided reaches .", "entity": [], "task": "NER"}
{"text": "The greatest risk of preterm prelabour rupture of membranes ( PPROM ) is preterm delivery .", "entity": [], "task": "NER"}
{"text": "The 2 . 3 x 10 ( 3 ) base SUF12 + transcript contains an open reading frame sufficient to encode a 88 x 10 ( 3 ) Mr protein .", "entity": [{"entity": "2 . 3 x 10 ( 3 ) base SUF12 + transcript", "entity_type": "GENE", "pos": [4, 44]}], "task": "NER"}
{"text": "This regulation is mediated by several kinases that phosphorylate specific residues in the different functional domains of the p53 molecule .", "entity": [{"entity": "p53 molecule", "entity_type": "GENE", "pos": [127, 139]}], "task": "NER"}
{"text": "In group I during the pain free period 26 of 81 patients had positive thallium - 201 scans , whereas 20 patients had an abnormal ECG at that time ; during angina 18 patients had transient ECG changes .", "entity": [], "task": "NER"}
{"text": "We examined the contribution of the M - MuLV enhancers to the transcriptional activity and pathogenesis of M - MuLV by constructing LTRs containing heterologous enhancer elements .", "entity": [{"entity": "M - MuLV enhancers", "entity_type": "GENE", "pos": [36, 54]}], "task": "NER"}
{"text": "Acute respiratory distress syndrome .", "entity": [], "task": "NER"}
{"text": "Serum creatinine kinase activity was 7 , 800 - 17 , 500 U / l , making acute muscle damage likely , probably rhabdomyolysis .", "entity": [{"entity": "creatinine kinase", "entity_type": "GENE", "pos": [6, 23]}], "task": "NER"}
{"text": "Transcriptional regulation of the murine k - fgf gene .", "entity": [{"entity": "murine k - fgf gene", "entity_type": "GENE", "pos": [34, 53]}], "task": "NER"}
{"text": "Fetal arterial and sagittal sinus pH , base excess , po2 , and oxygen saturation decreased , and hydrogen ion concentrations and pco2 increased during asphyxia alone and asphyxia plus isoflurane - oxygen .", "entity": [], "task": "NER"}
{"text": "To clarify the difference , both the Crk II and Crk II - 23 , proteins were expressed in E . coli and examined their binding capacity in vitro .", "entity": [{"entity": "Crk II", "entity_type": "GENE", "pos": [37, 43]}, {"entity": "Crk II - 23", "entity_type": "GENE", "pos": [48, 59]}], "task": "NER"}
{"text": "Growth hormone exerts its effects on the ovarian follicular cycle directly or by local production of insulin - like growth factor 1 ( IGF - 1 ) .", "entity": [{"entity": "Growth hormone", "entity_type": "GENE", "pos": [0, 14]}, {"entity": "insulin - like growth factor 1", "entity_type": "GENE", "pos": [101, 131]}, {"entity": "IGF - 1", "entity_type": "GENE", "pos": [134, 141]}], "task": "NER"}
{"text": "For the most part , only aerobic microbial degradation systems have been reported so far .", "entity": [], "task": "NER"}
{"text": "This is mediated by vascular remodeling , an active process that results in a change in the geometry of the blood vessel .", "entity": [], "task": "NER"}
{"text": "The results suggest that the posterior wall is more compliant than the anterior wall ( that is , for a given difference in transmural pressure , the local segment length change of the posterior wall was greater ) .", "entity": [], "task": "NER"}
{"text": "Although cardiac output decreased slightly with PCF , hemodynamic changes due to PCF were unlikely to account for the observed fall in PaO2 .", "entity": [], "task": "NER"}
{"text": "Swarming of Moraxella", "entity": [], "task": "NER"}
{"text": "Two patient groups were studied : Type I - - with a new ePTFE graft ; and Type II - - with thrombectomy and / or revision of a previously placed ePTFE graft .", "entity": [], "task": "NER"}
{"text": "No consensus binding sequence could be discerned in these fragments and bound factor is in rapid equilibrium with unbound .", "entity": [], "task": "NER"}
{"text": "As a quantitative index of cochlear function , 2f1 - f2 distortion - product otoacoustic emissions ( DPOAEs ) were monitored systematically over time in three groups of rabbits , with each group experiencing a unique paradigm that incorporated repeated exposure to the low - frequency tone .", "entity": [], "task": "NER"}
{"text": "Quasidiatomic study of Ly - alpha - producing H2 + - Ne collisions at keV energies .", "entity": [], "task": "NER"}
{"text": "Detailed analysis of the predicted amino acid sequence revealed sequence elements which are conserved in many DNA and RNA polymerases .", "entity": [{"entity": "DNA and RNA polymerases", "entity_type": "GENE", "pos": [110, 133]}], "task": "NER"}
{"text": "139La NQR relaxation and microSR study of Zn - doping effects in La2CuO4 .", "entity": [], "task": "NER"}
{"text": "We have previously reported the first isolation of a c - myc - null cell line .", "entity": [{"entity": "c - myc - null", "entity_type": "GENE", "pos": [53, 67]}], "task": "NER"}
{"text": "Our study investigated the hypothesis that the combination of a high NaCl diet and social isolation stress would increase systolic blood pressure ( SBP ) and endogenous sodium pump ligands ( SPL ) , ouabainlike compound ( OLC ) , and marinobufagenin ( MBG ) .", "entity": [], "task": "NER"}
{"text": "Percentage incremental 18 - OHB responses to metoclopramide were greater ( P less than 0 . 01 ) in the subjects after 5 days on a 200 - meq sodium intake than after 5 days on a 10 - meq sodium intake .", "entity": [], "task": "NER"}
{"text": "An additional stimulation of D1 receptors by giving SKF38393 30 min later produced an almost continuous pattern of jaw openings but less closure movements from the rest position , and the openings were accompanied by frequent tongue protrusions .", "entity": [{"entity": "D1 receptors", "entity_type": "GENE", "pos": [29, 41]}], "task": "NER"}
{"text": "PURPOSE : Second malignant neoplasms ( SMNs ) are a rare occurrence after the successful treatment of childhood cancer .", "entity": [], "task": "NER"}
{"text": "A p53 cDNA deletion mutant ( delta pro AE ) , which lacks this entire proline - rich domain ( deleted for amino acids 62 - 91 ) , was created and characterized for a variety of p53 functions .", "entity": [{"entity": "p53 cDNA", "entity_type": "GENE", "pos": [2, 10]}, {"entity": "p53", "entity_type": "GENE", "pos": [177, 180]}], "task": "NER"}
{"text": "Mutations in nifR1 ( ntrC ) and nifR4 ( rpoN , encoding sigma54 ) had no influence on xdh gene expression .", "entity": [{"entity": "nifR1", "entity_type": "GENE", "pos": [13, 18]}, {"entity": "ntrC", "entity_type": "GENE", "pos": [21, 25]}, {"entity": "nifR4", "entity_type": "GENE", "pos": [32, 37]}, {"entity": "rpoN", "entity_type": "GENE", "pos": [40, 44]}, {"entity": "sigma54", "entity_type": "GENE", "pos": [56, 63]}, {"entity": "xdh gene", "entity_type": "GENE", "pos": [86, 94]}], "task": "NER"}
{"text": "Candidate factors have been identified by the observation that changes in glucocorticoid induction parameters in CV - 1 cells could be reproduced by varying the cellular levels of coactivators [ transcriptional intermediary factor 2 ( TIF2 ) , steroid receptor coactivator 1 ( SRC - 1 ) , and amplified in breast cancer 1 ( AIB1 ) ] , comodulator [ CREB - binding protein ( CBP ) ] , or corepressor [ silencing mediator for retinoid and thyroid - hormone receptors ( SMRT ) ] without concomitant increases in GR .", "entity": [{"entity": "transcriptional intermediary factor 2", "entity_type": "GENE", "pos": [195, 232]}, {"entity": "TIF2", "entity_type": "GENE", "pos": [235, 239]}, {"entity": "steroid receptor coactivator 1", "entity_type": "GENE", "pos": [244, 274]}, {"entity": "SRC - 1", "entity_type": "GENE", "pos": [277, 284]}, {"entity": "amplified in breast cancer 1", "entity_type": "GENE", "pos": [293, 321]}, {"entity": "AIB1", "entity_type": "GENE", "pos": [324, 328]}, {"entity": "CREB - binding protein", "entity_type": "GENE", "pos": [349, 371]}, {"entity": "CBP", "entity_type": "GENE", "pos": [374, 377]}, {"entity": "silencing mediator for retinoid and thyroid - hormone receptors", "entity_type": "GENE", "pos": [401, 464]}, {"entity": "SMRT", "entity_type": "GENE", "pos": [467, 471]}, {"entity": "GR", "entity_type": "GENE", "pos": [509, 511]}], "task": "NER"}
{"text": "The pyridostigmine inhibited AChE recovered only in the 100 mumol kg - 1 kg oxime groups at the end of the experiment .", "entity": [{"entity": "AChE", "entity_type": "GENE", "pos": [29, 33]}], "task": "NER"}
{"text": "We compared retrospectively the efficacy of granulocyte colony stimulating factor ( G - CSF ) alone with chemotherapy plus G - CSF in mobilizing CD34 - positive cells in patients with malignant lymphoma .", "entity": [{"entity": "granulocyte colony stimulating factor", "entity_type": "GENE", "pos": [44, 81]}, {"entity": "G - CSF", "entity_type": "GENE", "pos": [84, 91]}, {"entity": "G - CSF", "entity_type": "GENE", "pos": [123, 130]}, {"entity": "CD34", "entity_type": "GENE", "pos": [145, 149]}], "task": "NER"}
{"text": "An additional dose of 20 - 25 Gy was delivered to the site of original involvement using an implant when feasible .", "entity": [], "task": "NER"}
{"text": "Activation of the receptor induces Ret phosphorylation that leads the survival - promoting effects .", "entity": [{"entity": "Ret", "entity_type": "GENE", "pos": [35, 38]}], "task": "NER"}
{"text": "Adenovirus infection of hepatoma cells inhibited transcription of the phosphoenolpyruvate carboxykinase ( GTP ) ( EC 4 . 1 . 1 . 32 ) ( PEPCK ) gene and virtually eliminated transcription of a chimeric gene which contained the PEPCK promoter linked to the structural gene for chloramphenicol acetyltransferase ( CAT ) .", "entity": [{"entity": "phosphoenolpyruvate carboxykinase", "entity_type": "GENE", "pos": [70, 103]}, {"entity": "EC 4 . 1 . 1 . 32", "entity_type": "GENE", "pos": [114, 131]}, {"entity": "PEPCK", "entity_type": "GENE", "pos": [136, 141]}, {"entity": "PEPCK promoter", "entity_type": "GENE", "pos": [227, 241]}, {"entity": "chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [276, 309]}, {"entity": "CAT", "entity_type": "GENE", "pos": [312, 315]}], "task": "NER"}
{"text": "Circulating immune complexes were determined by the method of phagocytosis and immunofluorescence .", "entity": [], "task": "NER"}
{"text": "LCCH1 was identical to the Rdl gene , a known GABA receptor subunit gene from D . melanogaster , whereas LCCH2 and LCCH3 were novel D . melanogaster sequences that exhibited structural similarity to other members of the ligand - gated chloride channel gene family .", "entity": [{"entity": "LCCH1", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "Rdl gene", "entity_type": "GENE", "pos": [27, 35]}, {"entity": "GABA receptor subunit gene", "entity_type": "GENE", "pos": [46, 72]}, {"entity": "LCCH2", "entity_type": "GENE", "pos": [105, 110]}, {"entity": "LCCH3", "entity_type": "GENE", "pos": [115, 120]}, {"entity": "ligand - gated chloride channel gene family", "entity_type": "GENE", "pos": [220, 263]}], "task": "NER"}
{"text": "In this report , we investigated whether the cleavage of the RRKR motif of MT - MMP1 by Golgi - associated furin is analogous to a similar enzyme activation mechanism observed with stromelysin - 3 .", "entity": [{"entity": "MT - MMP1", "entity_type": "GENE", "pos": [75, 84]}, {"entity": "Golgi - associated furin", "entity_type": "GENE", "pos": [88, 112]}, {"entity": "stromelysin - 3", "entity_type": "GENE", "pos": [181, 196]}], "task": "NER"}
{"text": "Lifestyle characteristics were ascertained by a self - administered questionnaire .", "entity": [], "task": "NER"}
{"text": "The oxalate oxidase method results in a mean and reference interval for oxalate excretion that are comparable with those by isotope dilution , gas - chromatographic , colorimetric , and other enzymic procedures .", "entity": [{"entity": "oxalate oxidase", "entity_type": "GENE", "pos": [4, 19]}], "task": "NER"}
{"text": "Normal replication of DNA A still carrying the AC3 ORF mutation was found in extracts from these plants .", "entity": [{"entity": "DNA A", "entity_type": "GENE", "pos": [22, 27]}, {"entity": "AC3 ORF", "entity_type": "GENE", "pos": [47, 54]}], "task": "NER"}
{"text": "Kohtz , J .", "entity": [], "task": "NER"}
{"text": "These data are discussed in the context of the pathogenesis and differential diagnosis of EEC .", "entity": [], "task": "NER"}
{"text": "These data suggest that the fibrinogen gamma chain region Gly190 - Val202 functions as a minimal recognition sequence for the leukocyte integrin CD11b / CD18 .", "entity": [{"entity": "fibrinogen gamma chain region Gly190 - Val202", "entity_type": "GENE", "pos": [28, 73]}, {"entity": "CD11b", "entity_type": "GENE", "pos": [145, 150]}, {"entity": "CD18", "entity_type": "GENE", "pos": [153, 157]}], "task": "NER"}
{"text": "OBJECTIVE : The audiologic presentation of vestibular schwannoma ( VS ) associated with neurofibromatosis type 2 ( NF2 ) has not been well characterized .", "entity": [], "task": "NER"}
{"text": "Siglec - 9 is predicted to contain three extracellular immunoglobulin - like domains that comprise an N - terminal V - set domain and two C2 - set domains , a transmembrane region and a cytoplasmic tail containing two putative tyrosine - based signaling motifs .", "entity": [{"entity": "Siglec - 9", "entity_type": "GENE", "pos": [0, 10]}, {"entity": "immunoglobulin - like domains", "entity_type": "GENE", "pos": [55, 84]}, {"entity": "N - terminal V - set domain", "entity_type": "GENE", "pos": [102, 129]}, {"entity": "C2 - set domains", "entity_type": "GENE", "pos": [138, 154]}], "task": "NER"}
{"text": "Development of P carinii pneumonia was associated with the stage of Kaposi ' s sarcoma , B subtype disease , and the presence of 0 . 20 X 10 ( 9 ) / L ( 200 / mm3 ) or fewer CD4 cells at study entry .", "entity": [{"entity": "CD4", "entity_type": "GENE", "pos": [174, 177]}], "task": "NER"}
{"text": "Dermatophagoides farinae - sensitized lymphocytes in asthmatic children as evaluated by interleukin - 2 ( IL - 2 ) production and acquisition of IL - 2 responsiveness", "entity": [{"entity": "interleukin - 2", "entity_type": "GENE", "pos": [88, 103]}, {"entity": "IL - 2", "entity_type": "GENE", "pos": [106, 112]}, {"entity": "IL - 2", "entity_type": "GENE", "pos": [145, 151]}], "task": "NER"}
{"text": "Adenocarcinoma and large cell carcinoma have a worse prognosis than squamous cell carcinoma in the T1N1 and T2N1 subsets .", "entity": [], "task": "NER"}
{"text": "The DNA element through which EBNA - 3C activates the LMP - 1 promoter includes a Spi - 1 / Spi - B binding site , previously characterized as an important EBNA - 2 response element .", "entity": [{"entity": "EBNA - 3C", "entity_type": "GENE", "pos": [30, 39]}, {"entity": "LMP - 1 promoter", "entity_type": "GENE", "pos": [54, 70]}, {"entity": "Spi - 1", "entity_type": "GENE", "pos": [82, 89]}, {"entity": "Spi - B", "entity_type": "GENE", "pos": [92, 99]}, {"entity": "EBNA - 2 response element", "entity_type": "GENE", "pos": [156, 181]}], "task": "NER"}
{"text": "Based on PCR strategies and expression studies , we define the genomic organization of the FUT8b gene .", "entity": [{"entity": "FUT8b gene", "entity_type": "GENE", "pos": [91, 101]}], "task": "NER"}
{"text": "Cord formation in BACTEC 7H12 medium for rapid , presumptive identification of Mycobacterium tuberculosis complex .", "entity": [], "task": "NER"}
{"text": "The effect of the NMDA - receptor antagonist ( + / - ) - CPP on the conditioned - reflex activation of an operant reaction in the brain electrical self - stimulation test in rats", "entity": [{"entity": "NMDA - receptor", "entity_type": "GENE", "pos": [18, 33]}], "task": "NER"}
{"text": "Treatment with H7 did not affect IL - 4R - mediated immediate signaling events such as tyrosine phosphorylation of Jak1 , Jak3 , insulin receptor substrate ( IRS ) - 1 and IRS - 2 , or tyrosine phosphorylation and DNA binding of Stat6 .", "entity": [{"entity": "IL - 4R", "entity_type": "GENE", "pos": [33, 40]}, {"entity": "Jak1", "entity_type": "GENE", "pos": [115, 119]}, {"entity": "Jak3", "entity_type": "GENE", "pos": [122, 126]}, {"entity": "insulin receptor substrate ( IRS ) - 1", "entity_type": "GENE", "pos": [129, 167]}, {"entity": "IRS - 2", "entity_type": "GENE", "pos": [172, 179]}, {"entity": "Stat6", "entity_type": "GENE", "pos": [229, 234]}], "task": "NER"}
{"text": "( 1982 ) .", "entity": [], "task": "NER"}
{"text": "Vasodilation in congestive heart failure is an established therapeutic principal .", "entity": [], "task": "NER"}
{"text": "The translational product of UL26 . 5 is infected - cell protein 35c , d ( ICP35c , d ) ( F .", "entity": [{"entity": "UL26 . 5", "entity_type": "GENE", "pos": [29, 37]}, {"entity": "infected - cell protein 35c , d", "entity_type": "GENE", "pos": [41, 72]}, {"entity": "ICP35c , d", "entity_type": "GENE", "pos": [75, 85]}], "task": "NER"}
{"text": "Our experience suggests that T2 weighting is adequate and is the method of choice for the early recognition of necrosis of the lunate .", "entity": [], "task": "NER"}
{"text": "Minor changes within the transmembrane domains ( TMs ) sometimes produced major effects and more drastic changes in the TMs ablated surface expression entirely .", "entity": [], "task": "NER"}
{"text": "Molecular analysis of the mannitol operon of Clostridium acetobutylicum encoding a phosphotransferase system and a putative PTS - modulated regulator .", "entity": [], "task": "NER"}
{"text": "Mammalian chromosome ends contain long arrays of TTAGGG repeats that are complexed to a telomere specific protein , the TTAGGG repeat binding factor , TRF1 .", "entity": [{"entity": "TTAGGG repeat binding factor", "entity_type": "GENE", "pos": [120, 148]}, {"entity": "TRF1", "entity_type": "GENE", "pos": [151, 155]}], "task": "NER"}
{"text": "HPV - 16 MARs are context dependent transcriptional enhancers , and activated expression of HPV - 16 oncogenes dependent on chromosomal integration may positively select tumorigenic cells during the multistep etiology of cervical cancer .", "entity": [], "task": "NER"}
{"text": "Vancomycin and tetracycline eliminated toxin in stools and delayed death .", "entity": [], "task": "NER"}
{"text": "This combination is considered pathognomonic for factitious hyperinsulinism .", "entity": [], "task": "NER"}
{"text": "The duration of naloxone appears to be dose - related , statistically significant up to approximately 1 . 5 hr .", "entity": [], "task": "NER"}
{"text": "In the present study , we report the entire genomic structure of KCNQ1 , which consists of 19 exons spanning 400 kb on chromosome 11p15 . 5 .", "entity": [{"entity": "KCNQ1", "entity_type": "GENE", "pos": [65, 70]}], "task": "NER"}
{"text": "A comparison between attenuation - corrected and - uncorrected transmission - emission SPECT images obtained with Tl - 201 in CAD patients", "entity": [], "task": "NER"}
{"text": "Reconstruction time for a 64 x 64 matrix is approximately 45 s / transaxial slice .", "entity": [], "task": "NER"}
{"text": "The hyperpigmentation is linked to the presence of numerous single melanosomes and polymelanosomes in keratinocytes at all levels of the epidermis , and in dermal Factor XIIIa - positive dendrocytes .", "entity": [{"entity": "Factor XIIIa", "entity_type": "GENE", "pos": [163, 175]}], "task": "NER"}
{"text": "The immediate and remote results of surgical treatment of renal adenocarcinomas .", "entity": [], "task": "NER"}
{"text": "Six patients underwent an electrophysiologic study .", "entity": [], "task": "NER"}
{"text": "In agreement with this , archaea appear to lack eIF5 , eIF2B and the lysine - rich binding domain for these factors in their eIF2beta homolog .", "entity": [{"entity": "eIF5", "entity_type": "GENE", "pos": [48, 52]}, {"entity": "eIF2B", "entity_type": "GENE", "pos": [55, 60]}, {"entity": "eIF2beta homolog", "entity_type": "GENE", "pos": [125, 141]}], "task": "NER"}
{"text": "However , the MCMI - III group profile was significantly lower in magnitude compared with the MCMI - II .", "entity": [], "task": "NER"}
{"text": "Spen is the only known homeotic protein with RNP binding motifs , which indicates that splicing , transport , or other RNA regulatory steps are involved in the diversification of segmental morphology .", "entity": [{"entity": "Spen", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "homeotic protein", "entity_type": "GENE", "pos": [23, 39]}], "task": "NER"}
{"text": "The existence of universal non - specific mechanism of action of external factors upon the living tissue based on the DEL - reaction is suggested .", "entity": [], "task": "NER"}
{"text": "The impairment of the nocturnal secretion was related to the subjects ' age and , for the GH secretory pattern only , also to the MMSE score .", "entity": [{"entity": "GH", "entity_type": "GENE", "pos": [90, 92]}], "task": "NER"}
{"text": "In this study , we cloned the full - length cDNA of mouse PAX4 by RACE ( rapid amplification of cDNA ends ) using RNA from MIN6 cells , a mouse insulinoma cell line .", "entity": [{"entity": "PAX4", "entity_type": "GENE", "pos": [58, 62]}], "task": "NER"}
{"text": "Sixteen patients ( 25 . 4 % ) encountered rejection while weaning at median period of 9 . 5 months ( range , 1 - 63 months ) from the start of weaning .", "entity": [], "task": "NER"}
{"text": "Earlier nonoptical methods probably did not include the portion of the film that contained mucus .", "entity": [], "task": "NER"}
{"text": "Antibodies specific to the different members of the Jun and Fos family of transcription factors show that , in gel retardation assays , a Jun - like factor is a component of the H3 . 2 specific complex .", "entity": [{"entity": "Jun", "entity_type": "GENE", "pos": [52, 55]}, {"entity": "Fos family of transcription factors", "entity_type": "GENE", "pos": [60, 95]}, {"entity": "Jun - like factor", "entity_type": "GENE", "pos": [138, 155]}, {"entity": "H3 . 2 specific complex", "entity_type": "GENE", "pos": [178, 201]}], "task": "NER"}
{"text": "CONCLUSIONS : Results of this study suggest that both male and female soldiers who are diagnosed with chlamydia infections have relatively high risks of reinfection through their 20s .", "entity": [], "task": "NER"}
{"text": "Here we report that point mutations of the Abd - B gene in trans suppress the Fab - 7 phenotype in a pairing - dependent manner and thus represent a type of transvection .", "entity": [{"entity": "Abd - B gene", "entity_type": "GENE", "pos": [43, 55]}, {"entity": "Fab - 7 phenotype", "entity_type": "GENE", "pos": [78, 95]}], "task": "NER"}
{"text": "The glucose effect on the pyruvate kinase gene is reversibly antagonized by agents increasing intracellular cAMP .", "entity": [{"entity": "pyruvate kinase gene", "entity_type": "GENE", "pos": [26, 46]}], "task": "NER"}
{"text": "Here , we report the isolation of a new spindle checkpoint gene , mph1 ( Mps1p - like pombe homolog ) , in the fission yeast Schizosaccharomyces pombe , that is required for checkpoint activation in response to spindle defects . mph1 functions upstream of mad2 , a previously characterized component of the spindle checkpoint .", "entity": [{"entity": "mph1", "entity_type": "GENE", "pos": [66, 70]}, {"entity": "Mps1p - like pombe homolog", "entity_type": "GENE", "pos": [73, 99]}, {"entity": "mph1", "entity_type": "GENE", "pos": [229, 233]}, {"entity": "mad2", "entity_type": "GENE", "pos": [256, 260]}], "task": "NER"}
{"text": "In addition , measurements of shielded and unshielded syringes containing 99mTc - labelled radiopharmaceuticals were carried out .", "entity": [], "task": "NER"}
{"text": "Combination chemotherapy in advanced ovarian cancer .", "entity": [], "task": "NER"}
{"text": "The results in the untreated patients demonstrate the primary importance of bulk reduction at initial laparotomy .", "entity": [], "task": "NER"}
{"text": "Vertebrate U6 small nuclear RNA ( snRNA ) loci exemplify a novel class of polymerase III - transcribed genes that lack an intragenic control region ( ICR ) .", "entity": [{"entity": "U6 small nuclear RNA", "entity_type": "GENE", "pos": [11, 31]}, {"entity": "polymerase III", "entity_type": "GENE", "pos": [74, 88]}], "task": "NER"}
{"text": "The well - trained group was measured once in the respiration chamber for 36 h according to the same protocol .", "entity": [], "task": "NER"}
{"text": "PtdIns ( 4 , 5 ) P2 synthesis , on the other hand , is only moderately affected even in fab1Delta mutants .", "entity": [{"entity": "PtdIns ( 4 , 5 ) P2", "entity_type": "GENE", "pos": [0, 19]}, {"entity": "fab1Delta mutants", "entity_type": "GENE", "pos": [88, 105]}], "task": "NER"}
{"text": "Protein sequencing , electrophoretic mobility shift assay , and immunoblot analyses identify p54 and p47 / 48 as members of the hepatocyte nuclear factor 3 ( HNF3 [ forkhead ] ) family of transcription factors . p54 belongs to the subfamily of HNF3 beta proteins , while p47 / 48 binding activity includes HNF3 gamma .", "entity": [{"entity": "p54", "entity_type": "GENE", "pos": [93, 96]}, {"entity": "p47 / 48", "entity_type": "GENE", "pos": [101, 109]}, {"entity": "hepatocyte nuclear factor 3", "entity_type": "GENE", "pos": [128, 155]}, {"entity": "HNF3", "entity_type": "GENE", "pos": [158, 162]}, {"entity": "forkhead", "entity_type": "GENE", "pos": [165, 173]}, {"entity": "p54", "entity_type": "GENE", "pos": [212, 215]}, {"entity": "HNF3 beta proteins", "entity_type": "GENE", "pos": [244, 262]}, {"entity": "p47 / 48", "entity_type": "GENE", "pos": [271, 279]}, {"entity": "HNF3 gamma", "entity_type": "GENE", "pos": [306, 316]}], "task": "NER"}
{"text": "Molecular analysis indicated that inactivation of H - 2L expression in nearly every null clone resulted from an apparent deletion or rearrangement of 5 ' - flanking and 5 ' - coding H - 2L sequences , with breakpoints consistently mapping to within a 550 bp GC - rich region between exon 1 and the middle of intron 2 .", "entity": [{"entity": "H - 2L", "entity_type": "GENE", "pos": [50, 56]}, {"entity": "5 ' - flanking and 5 ' - coding H - 2L sequences", "entity_type": "GENE", "pos": [150, 198]}], "task": "NER"}
{"text": "CBD exploration was avoided in 7 patients with normal POC .", "entity": [], "task": "NER"}
{"text": "These mutations prevent FKBP12 - rapamycin binding to TOR2 , as assayed with the two - hybrid system .", "entity": [{"entity": "FKBP12", "entity_type": "GENE", "pos": [24, 30]}, {"entity": "TOR2", "entity_type": "GENE", "pos": [54, 58]}], "task": "NER"}
{"text": "The psbA gene encodes the D1 protein of photosystem II , which is synthesized at very high rates in the light in order to replace photodamaged protein .", "entity": [{"entity": "psbA gene", "entity_type": "GENE", "pos": [4, 13]}, {"entity": "D1 protein", "entity_type": "GENE", "pos": [26, 36]}, {"entity": "photosystem II", "entity_type": "GENE", "pos": [40, 54]}], "task": "NER"}
{"text": "The TCR beta enhancer was active on both the minimal simian virus 40 promoter and a TCR beta variable gene promoter in both TCR alpha / beta + and TCR gamma / delta + T cells .", "entity": [{"entity": "TCR beta enhancer", "entity_type": "GENE", "pos": [4, 21]}, {"entity": "minimal simian virus 40 promoter", "entity_type": "GENE", "pos": [45, 77]}, {"entity": "TCR beta variable gene promoter", "entity_type": "GENE", "pos": [84, 115]}, {"entity": "TCR alpha / beta", "entity_type": "GENE", "pos": [124, 140]}, {"entity": "TCR gamma / delta", "entity_type": "GENE", "pos": [147, 164]}], "task": "NER"}
{"text": "Fibrosis of the adjacent myocardium was seen in five cases .", "entity": [], "task": "NER"}
{"text": "Symptoms , skin - prick tests ( SPT ) with environmental allergens and Pt salt , total serum IgE , lung function , and bronchial hyperresponsiveness were assessed by standard procedures .", "entity": [{"entity": "serum IgE", "entity_type": "GENE", "pos": [87, 96]}], "task": "NER"}
{"text": "These findings suggest that T3R can repress or activate transcription while tethered to the LBD of GAL4 - RXR and that heterodimerization can occur in vivo without stabilization by hormone response elements .", "entity": [{"entity": "T3R", "entity_type": "GENE", "pos": [28, 31]}, {"entity": "GAL4", "entity_type": "GENE", "pos": [99, 103]}, {"entity": "RXR", "entity_type": "GENE", "pos": [106, 109]}], "task": "NER"}
{"text": "During 4 % O2 ventilation , baseline pulmonary vascular resistance ( PVR ) and the dilator response to both ACh and SNP were greater in 2D lungs .", "entity": [], "task": "NER"}
{"text": "HGF treatment increased cyclin A , cyclin G1 and nuclear transcriptional factor ( NFkappaB ) protein expression .", "entity": [{"entity": "HGF", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "cyclin A", "entity_type": "GENE", "pos": [24, 32]}, {"entity": "cyclin G1", "entity_type": "GENE", "pos": [35, 44]}, {"entity": "NFkappaB", "entity_type": "GENE", "pos": [82, 90]}], "task": "NER"}
{"text": "Surprisingly , in adult animals , the suprabasal expression of dnRXR alpha significantly reduced the ability of topically applied tRA to stimulate proliferation of undifferentiated keratinocytes in the basal layer of epidermis .", "entity": [{"entity": "dnRXR alpha", "entity_type": "GENE", "pos": [63, 74]}], "task": "NER"}
{"text": "A third - order polynominal fit showed a good correlation for the parameter Q * and MTT , whereas T and SImax were found to have a poor correlation .", "entity": [], "task": "NER"}
{"text": "This article focuses on a general approach to the use of ARV agents .", "entity": [], "task": "NER"}
{"text": "Although FKH2 is redundant with FKH1 in controlling pseudohyphal growth , the two genes have different functions in silencing HMRa .", "entity": [{"entity": "FKH2", "entity_type": "GENE", "pos": [9, 13]}, {"entity": "FKH1", "entity_type": "GENE", "pos": [32, 36]}, {"entity": "HMRa", "entity_type": "GENE", "pos": [126, 130]}], "task": "NER"}
{"text": "These results demonstrate the extensive homology in sequence among light chains of IgM kappa autoantibodies and indicate that a particular V kappa germ line gene , kappa IIIb , is expressed as a phylogenetic response to certain self antigens or as part of a selection process by which these autoimmune responses are regulated .", "entity": [{"entity": "IgM kappa autoantibodies", "entity_type": "GENE", "pos": [83, 107]}, {"entity": "V kappa germ line gene", "entity_type": "GENE", "pos": [139, 161]}, {"entity": "kappa IIIb", "entity_type": "GENE", "pos": [164, 174]}], "task": "NER"}
{"text": "The aim of the present study was to investigate the influence of long term intravenous administration of naftidrofuryl ( Dusodril - Lipha Arzn ) twice daily in a dose of 200 mg in continuous , 4 - hour infusion in 500 ml 0 . 9 % NaCl to the patients suffering from a peripheral arterial occlusive disease ( PAOD ) in a clinical condition with special attention paid to transcutaneous partial oxygen pressure measurements ( tcPO2 ) and rheographic parameters .", "entity": [], "task": "NER"}
{"text": "We concluded that RXR - gamma induced terminal differentiation in SCC lines , suggesting a potential tumor suppressor function for this transcription factor .", "entity": [{"entity": "RXR - gamma", "entity_type": "GENE", "pos": [18, 29]}], "task": "NER"}
{"text": "Finally , there is now appropriate recognition of the pivotal role of BP reduction in forestalling pressure - related cardiovascular complications , even among high - risk persons with diabetes mellitus and renal insufficiency .", "entity": [], "task": "NER"}
{"text": "RNA determinants required for L4 - mediated attenuation control of the S10 r - protein operon of Escherichia coli .", "entity": [{"entity": "L4", "entity_type": "GENE", "pos": [30, 32]}, {"entity": "S10 r - protein operon of Escherichia coli", "entity_type": "GENE", "pos": [71, 113]}], "task": "NER"}
{"text": "The psh3 ( + ) gene encodes a protein of 215 amino acids , which shares a high degree of structural and functional similarity with Shr3p .", "entity": [{"entity": "psh3 ( + ) gene", "entity_type": "GENE", "pos": [4, 19]}, {"entity": "Shr3p", "entity_type": "GENE", "pos": [131, 136]}], "task": "NER"}
{"text": "A very large PC LAN as the basis for a hospital information system .", "entity": [], "task": "NER"}
{"text": "A rapid mixing device for quasielastic light scattering studies of reacting systems .", "entity": [], "task": "NER"}
{"text": "After institution of insulin treatment , diabetic control was improved as demonstrated by decreasing levels of HbA1 .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [21, 28]}, {"entity": "HbA1", "entity_type": "GENE", "pos": [111, 115]}], "task": "NER"}
{"text": "It is not tested yet , whether the extent of glaucoma damage should be better quantified using reference plane 1 or 2 .", "entity": [], "task": "NER"}
{"text": "Based on the deduced amino acid sequence identity we designated GAPC1 and GAPC2 as group I ( 97 % identical ) and GAPC3 and GAPC4 as group II ( 99 . 4 % identical ) .", "entity": [{"entity": "GAPC1", "entity_type": "GENE", "pos": [64, 69]}, {"entity": "GAPC2", "entity_type": "GENE", "pos": [74, 79]}, {"entity": "GAPC3", "entity_type": "GENE", "pos": [114, 119]}, {"entity": "GAPC4", "entity_type": "GENE", "pos": [124, 129]}], "task": "NER"}
{"text": "In analogy to human CD70 , mCD70 transcript levels are strongly but transiently up - regulated during lymphocyte activation , which is in line with a role for the CD27 - CD70 receptor pair early in the immune response .", "entity": [{"entity": "human CD70", "entity_type": "GENE", "pos": [14, 24]}, {"entity": "mCD70 transcript", "entity_type": "GENE", "pos": [27, 43]}, {"entity": "CD27 - CD70 receptor", "entity_type": "GENE", "pos": [163, 183]}], "task": "NER"}
{"text": "Both parameters were determined in an individual eye by applying the dye first by iontophoresis and then by intravitreal injection , which allows the influence of fluorescein glucuronide on the fluorophotometric measurements to be excluded .", "entity": [], "task": "NER"}
{"text": "Phase I clinical trial with a combination of methotrexate and mitomycin C .", "entity": [], "task": "NER"}
{"text": "A total of 114 animals were infected by E . coli O2 : K1 : H4 by the hematogenic route .", "entity": [], "task": "NER"}
{"text": "Expression of a cDNA clone in yeast containing a large portion of the open reading frame produced cAMP PDEase activity identical in properties to the Drosophila enzyme affected by the dnc mutation .", "entity": [{"entity": "cAMP PDEase", "entity_type": "GENE", "pos": [98, 109]}, {"entity": "dnc mutation", "entity_type": "GENE", "pos": [184, 196]}], "task": "NER"}
{"text": "CONCLUSIONS : These results suggest that , by interacting with cellular transcription factors and cofactors , vIRF - 2 may modulate the expression of the early inflammatory genes and potentially deregulate the immune system .", "entity": [{"entity": "vIRF - 2", "entity_type": "GENE", "pos": [110, 118]}], "task": "NER"}
{"text": "It has been demonstrated that stimulation of the pontomesencephalic parabrachial region ( PBR ) by microinjection of cholinergic drugs or electricity in the cat produces potent pain suppression which is not antagonized by the opiate antagonist , naloxone .", "entity": [], "task": "NER"}
{"text": "AIMS : The aim of this study was to assess static and dynamic bone changes in patients suffering from rickets .", "entity": [], "task": "NER"}
{"text": "The homeodomain transcription factor CDP / cut interacts with the cell cycle regulatory element of histone H4 genes packaged into nucleosomes .", "entity": [{"entity": "homeodomain transcription factor", "entity_type": "GENE", "pos": [4, 36]}, {"entity": "CDP", "entity_type": "GENE", "pos": [37, 40]}, {"entity": "cut", "entity_type": "GENE", "pos": [43, 46]}, {"entity": "histone H4 genes", "entity_type": "GENE", "pos": [99, 115]}], "task": "NER"}
{"text": "K . , Weiss , M .", "entity": [], "task": "NER"}
{"text": "Thus , IF - laser therapy has a certain antioxidative effect by increasing SOD activity in RA patients ' blood cells and reducing the production of highly reactive oxygen and nitrogen forms .", "entity": [{"entity": "SOD", "entity_type": "GENE", "pos": [75, 78]}], "task": "NER"}
{"text": "During hexamethylene bisactamide ( HMBA ) - induced differentiation of murine erythroleukemia ( MEL ) cells erythroid genes are transcriptionally activated while c - myb and several other nuclear proto - oncogenes are down - regulated .", "entity": [{"entity": "c - myb", "entity_type": "GENE", "pos": [162, 169]}], "task": "NER"}
{"text": "We now report identification and analysis of transcriptional activities mediated by three cis - acting sites within a 90 - bp portion of the rDNA enhancer designated the modulator region .", "entity": [], "task": "NER"}
{"text": "Background reduction with various agents had a prominent effect on DTIn1 as well as 99mTc - DTPA biodistribution .", "entity": [], "task": "NER"}
{"text": "Influence of copper addition .", "entity": [], "task": "NER"}
{"text": "In human WI38 cells , the E1B 19K gene mutant viruses had a substantial growth advantage over the wild - type virus , yielding 500 - fold - higher titers .", "entity": [{"entity": "E1B 19K gene mutant", "entity_type": "GENE", "pos": [26, 45]}], "task": "NER"}
{"text": "The cooperation between health and hospital services", "entity": [], "task": "NER"}
{"text": "The N - terminal sequence of the extracellular MEP20 , TKVAS , was found at aa 194 - 198 within the ORF .", "entity": [{"entity": "extracellular MEP20", "entity_type": "GENE", "pos": [33, 52]}, {"entity": "TKVAS", "entity_type": "GENE", "pos": [55, 60]}], "task": "NER"}
{"text": "Furthermore , mutations in element II result in changes in the RNA structure near element III , consistent with a long - range interaction that may promote translation .", "entity": [], "task": "NER"}
{"text": "( We observed a ferritin value as high as 47 mg / L in one patient . ) Results with all these kits did not inter - compare well for ferritin concentrations greater than 300 micrograms / L , a finding that casts further doubt on the controversial use of serum ferritin measurement in cases of iron overload .", "entity": [{"entity": "ferritin", "entity_type": "GENE", "pos": [16, 24]}, {"entity": "ferritin", "entity_type": "GENE", "pos": [132, 140]}, {"entity": "serum ferritin", "entity_type": "GENE", "pos": [253, 267]}], "task": "NER"}
{"text": "Most other differences between these two Leporipoxviruses are located in the telomeres .", "entity": [], "task": "NER"}
{"text": "The Tat protein coded by human immunodeficiency virus ( HIV ) is a strong activator of viral gene expression from the long terminal repeat ( LTR ) .", "entity": [{"entity": "Tat protein", "entity_type": "GENE", "pos": [4, 15]}], "task": "NER"}
{"text": "This case report describes the treatment of a patient with periodontosis .", "entity": [], "task": "NER"}
{"text": "Upstream tissue inhibitor of metalloproteinases - 1 ( TIMP - 1 ) element - 1 , a novel and essential regulatory DNA motif in the human TIMP - 1 gene promoter , directly interacts with a 30 - kDa nuclear protein .", "entity": [{"entity": "tissue inhibitor of metalloproteinases - 1 ( TIMP - 1 ) element - 1", "entity_type": "GENE", "pos": [9, 76]}, {"entity": "human TIMP - 1 gene promoter", "entity_type": "GENE", "pos": [129, 157]}], "task": "NER"}
{"text": "We propose that U73 is involved in methylation of the G1739 residue of the human 28S rRNA .", "entity": [{"entity": "U73", "entity_type": "GENE", "pos": [16, 19]}, {"entity": "human 28S rRNA", "entity_type": "GENE", "pos": [75, 89]}], "task": "NER"}
{"text": "Also , the placebo nondepressed patients had significantly better treatment outcome compared with the placebo depressed patients .", "entity": [], "task": "NER"}
{"text": "Animals were divided into six equal groups as follows : ( 1 ) no oral drug ( water ) , no hemodilution , no IV drug ( saline ) ; ( 2 ) oral water , hemodilution , IV saline ; ( 3 ) oral water , no hemodilution , IV propranolol ; ( 4 ) oral water , hemodilution , IV propranolol ; ( 5 ) oral propranolol , no hemodilution , IV saline ; and ( 6 ) oral propranolol , hemodilution , IV saline .", "entity": [], "task": "NER"}
{"text": "We found 4 highly conserved regions to vertebrate Hsp90 exclusively and 27 amino acids conserved among but differing between Hsp90 alpha and Hsp90 beta sequences .", "entity": [{"entity": "vertebrate Hsp90", "entity_type": "GENE", "pos": [39, 55]}, {"entity": "Hsp90 alpha", "entity_type": "GENE", "pos": [125, 136]}, {"entity": "Hsp90 beta sequences", "entity_type": "GENE", "pos": [141, 161]}], "task": "NER"}
{"text": "Four newborns in this group became HBsAg carriers .", "entity": [{"entity": "HBsAg", "entity_type": "GENE", "pos": [35, 40]}], "task": "NER"}
{"text": "It tends to be higher between frazioni of the same community than between communities .", "entity": [], "task": "NER"}
{"text": "In previous studies , we showed that the nuclear import of SREBP - 2 occurs via the direct interaction of importin beta with the HLH - Zip domain .", "entity": [{"entity": "SREBP - 2", "entity_type": "GENE", "pos": [59, 68]}, {"entity": "importin beta", "entity_type": "GENE", "pos": [106, 119]}], "task": "NER"}
{"text": "The destruction of the mesometrium did not lengthen the oestrous cycle .", "entity": [], "task": "NER"}
{"text": "Ftz , on the other hand , influences Ftz - F1 activity by interacting with its AF - 2 domain in a manner that mimics a nuclear receptor coactivator .", "entity": [{"entity": "Ftz", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "Ftz", "entity_type": "GENE", "pos": [37, 40]}, {"entity": "F1", "entity_type": "GENE", "pos": [43, 45]}], "task": "NER"}
{"text": "Type C units summate the responses to the two - tone stimulus , and show little or no inhibitory influences .", "entity": [], "task": "NER"}
{"text": "19 , 4967 - 4973 ) .", "entity": [], "task": "NER"}
{"text": "CONCLUSIONS : In the majority of patients with severe ulcerative colitis , circulating concentrations of NOX are increased at presentation and fall promptly during parenteral steroid therapy , irrespective of clinical outcome .", "entity": [], "task": "NER"}
{"text": "A cDNA for human microfibril - associated glycoprotein - 2 ( MAGP - 2 ) was used to screen a human leukocyte genomic DNA library in EMBL - 3 vector .", "entity": [{"entity": "human microfibril - associated glycoprotein - 2", "entity_type": "GENE", "pos": [11, 58]}, {"entity": "MAGP - 2", "entity_type": "GENE", "pos": [61, 69]}], "task": "NER"}
{"text": "Screening of a human foetal brain genomic DNA library allowed us to isolate an EcoRI - EcoRI fragment containing 6 kb of the 5 ' - flanking region , the open reading frame and 4 kb of the 3 ' - flanking region of the alpha2C4 gene .", "entity": [{"entity": "EcoRI", "entity_type": "GENE", "pos": [79, 84]}, {"entity": "EcoRI", "entity_type": "GENE", "pos": [87, 92]}, {"entity": "alpha2C4 gene", "entity_type": "GENE", "pos": [217, 230]}], "task": "NER"}
{"text": "Using gel retardation analysis , four binding sites for Rap1p have been identified within the promoter of the RAP1 gene .", "entity": [{"entity": "Rap1p", "entity_type": "GENE", "pos": [56, 61]}, {"entity": "RAP1 gene", "entity_type": "GENE", "pos": [110, 119]}], "task": "NER"}
{"text": "They are transduced through TM to the cytoplasmic portion ( cytoloops and the C - terminal tail ) of the receptor and then , transferred to cytoplasmic signaling molecules , such as G protein .", "entity": [{"entity": "G protein", "entity_type": "GENE", "pos": [182, 191]}], "task": "NER"}
{"text": "Sgs - 4 is one of the eight known genes coding for larval secretion proteins in Drosophila melanogaster .", "entity": [{"entity": "Sgs - 4", "entity_type": "GENE", "pos": [0, 7]}], "task": "NER"}
{"text": "Unlike CSK , the SH3 domain of HYL was unique since the ALYDY motif was absent .", "entity": [{"entity": "CSK", "entity_type": "GENE", "pos": [7, 10]}, {"entity": "SH3 domain", "entity_type": "GENE", "pos": [17, 27]}, {"entity": "HYL", "entity_type": "GENE", "pos": [31, 34]}], "task": "NER"}
{"text": "This enzyme is distinct from other known E3s , including E3 alpha / UBR1 , E3 beta , and E6 - AP .", "entity": [{"entity": "E3s", "entity_type": "GENE", "pos": [41, 44]}, {"entity": "E3 alpha", "entity_type": "GENE", "pos": [57, 65]}, {"entity": "UBR1", "entity_type": "GENE", "pos": [68, 72]}, {"entity": "E3 beta", "entity_type": "GENE", "pos": [75, 82]}, {"entity": "E6 - AP", "entity_type": "GENE", "pos": [89, 96]}], "task": "NER"}
{"text": "RESULTS : Although low levels of vIRF - 2 mRNAs can be detected in the HHV - 8 - positive BCBL - 1 tumor cell line , 12 - 0 - tetradecanoylphorbol - 13 - acetate ( TPA ) treatment does not stimulate expression of vIRF - 2 gene together with primary lytic cycle genes .", "entity": [{"entity": "vIRF - 2 mRNAs", "entity_type": "GENE", "pos": [33, 47]}, {"entity": "vIRF - 2 gene", "entity_type": "GENE", "pos": [213, 226]}], "task": "NER"}
{"text": "Primary TJRs were clinically evaluated for degree of osteoarthrosis .", "entity": [], "task": "NER"}
{"text": "We suggest that this relatively small deletion affects a segment containing 3 ' VH genes with important regulatory functions , the loss of which leads to the ali phenotype .", "entity": [{"entity": "3 ' VH genes", "entity_type": "GENE", "pos": [76, 88]}], "task": "NER"}
{"text": "Apoptosis triggered through Fas and F / F was inhibited by coexpression of CrmA and p35 , but not Bcl - xL .", "entity": [{"entity": "Fas", "entity_type": "GENE", "pos": [28, 31]}, {"entity": "F / F", "entity_type": "GENE", "pos": [36, 41]}, {"entity": "CrmA", "entity_type": "GENE", "pos": [75, 79]}, {"entity": "p35", "entity_type": "GENE", "pos": [84, 87]}, {"entity": "Bcl - xL", "entity_type": "GENE", "pos": [98, 106]}], "task": "NER"}
{"text": "Expression of Helios was detected in the earliest hematopoietic sites of the embryo , in hematopoietic stem cells in the adult and was subsequently restricted to a subset of cells in the T cell lineage .", "entity": [{"entity": "Helios", "entity_type": "GENE", "pos": [14, 20]}], "task": "NER"}
{"text": "It produced extrapyramidal disturbances in nearly every subject , the most common being akathisia and the most severe , in the case of one individual , being acute dystonia .", "entity": [], "task": "NER"}
{"text": "Electron microscopy of pH 7 . 5 - treated TMV particles incubated in SPN - treated wheatgerm extract or rabbit reticulocyte lysate , showed that approximately 10 % of virions complexed with one ribosome and approximately 10 % with two bound ribosomes , confirming that omega at least had been uncoated .", "entity": [{"entity": "SPN", "entity_type": "GENE", "pos": [69, 72]}], "task": "NER"}
{"text": "The absorbance of the eluent was monitored at 254 nm .", "entity": [], "task": "NER"}
{"text": "As anticipated , both intracellular p54 - SAPKbeta activation and Bcl - 2 phosphorylation are blocked by co - transfection with the MAP kinase specific phosphatase MKP3 / PYST1 .", "entity": [{"entity": "p54", "entity_type": "GENE", "pos": [36, 39]}, {"entity": "SAPKbeta", "entity_type": "GENE", "pos": [42, 50]}, {"entity": "Bcl - 2", "entity_type": "GENE", "pos": [66, 73]}, {"entity": "MAP kinase", "entity_type": "GENE", "pos": [132, 142]}, {"entity": "MKP3", "entity_type": "GENE", "pos": [164, 168]}, {"entity": "PYST1", "entity_type": "GENE", "pos": [171, 176]}], "task": "NER"}
{"text": "All patients studied were pregnant women and their delivered children .", "entity": [], "task": "NER"}
{"text": "PRP20 is related , both in structure and function , to the RCC1 gene of mammals and the PIM1 gene of Schizosaccharomyces pombe , both of which appear to regulate entry into mitosis and chromosome condensation .", "entity": [{"entity": "PRP20", "entity_type": "GENE", "pos": [0, 5]}, {"entity": "RCC1 gene", "entity_type": "GENE", "pos": [59, 68]}, {"entity": "PIM1 gene", "entity_type": "GENE", "pos": [88, 97]}], "task": "NER"}
{"text": "Using this oligonucleotide as a probe , an 8 - kilobase HindIII fragment of genomic DNA was isolated and subjected to Sanger dideoxy DNA sequencing .", "entity": [{"entity": "HindIII", "entity_type": "GENE", "pos": [56, 63]}], "task": "NER"}
{"text": "The Rep proteins of adeno - associated virus type 2 ( AAV ) are known to bind to Rep recognition sequences ( RRSs ) in the AAV inverted terminal repeats ( ITRs ) , the AAV p5 promoter , and the preferred AAV integration site in human chromosome 19 , called AAVS1 .", "entity": [{"entity": "Rep proteins", "entity_type": "GENE", "pos": [4, 16]}, {"entity": "Rep recognition sequences", "entity_type": "GENE", "pos": [81, 106]}, {"entity": "RRSs", "entity_type": "GENE", "pos": [109, 113]}, {"entity": "AAV p5 promoter", "entity_type": "GENE", "pos": [168, 183]}], "task": "NER"}
{"text": "The electrocardiogram in tachycardia .", "entity": [], "task": "NER"}
{"text": "It is noteworthy that under more physiological conditions mimicking the cellular GDP / GTP ratio , Raf enhances the GEF - stimulated GDP / GTP exchange on Ha - Ras , in agreement with the sequestration of Ras . GTP by Raf .", "entity": [{"entity": "Raf", "entity_type": "GENE", "pos": [99, 102]}, {"entity": "GEF", "entity_type": "GENE", "pos": [116, 119]}, {"entity": "Ha - Ras", "entity_type": "GENE", "pos": [155, 163]}, {"entity": "Ras . GTP", "entity_type": "GENE", "pos": [205, 214]}, {"entity": "Raf", "entity_type": "GENE", "pos": [218, 221]}], "task": "NER"}
{"text": "In this study , we show that HNF - 4 , a member of the steroid hormone receptor superfamily , binds the AF - 1 site on the apoB promoter and through it activates transcription in transient transfection assays in both liver and non - liver cell lines , HepG2 and HeLa , respectively .", "entity": [{"entity": "HNF - 4", "entity_type": "GENE", "pos": [29, 36]}, {"entity": "steroid hormone receptor superfamily", "entity_type": "GENE", "pos": [55, 91]}, {"entity": "AF - 1 site", "entity_type": "GENE", "pos": [104, 115]}, {"entity": "apoB promoter", "entity_type": "GENE", "pos": [123, 136]}], "task": "NER"}
{"text": "In Cos 7 cells transfected with oCRF1var , cAMP accumulation was only observed at the highest concentration of oCRF utilized ( 100 nM ) .", "entity": [{"entity": "oCRF1var", "entity_type": "GENE", "pos": [32, 40]}, {"entity": "oCRF", "entity_type": "GENE", "pos": [111, 115]}], "task": "NER"}
{"text": "Usefulness of glucocorticoids in the treatment of congestive heart failure", "entity": [], "task": "NER"}
{"text": "RESULTS : In 76 trials , 5 , 351 patients received 24 different regimens of droperidol .", "entity": [], "task": "NER"}
{"text": "The local median scores ( ranges ) of the above tests were as follows - AMT : 9 ( 6 - 10 ) ; CMMS : 25 ( 16 - 28 ) ; SBT : 2 ( 0 - 10 ) ; WL - i : 17 ( 8 - 27 ) ; WL - d : 5 ( 0 - 10 ) ; WL - r : 9 ( 1 - 10 ) ; ST : 13 ( 6 - 25 ) ; BNT : 14 ( 10 - 15 ) ; CPT : 1 ( 0 - 3 ) ; BDT : 19 ( 0 - 42 ) ; OAT : 20 ( 3 - 33 ) .", "entity": [], "task": "NER"}
{"text": "The organization of the MBP - A gene is very similar to the arrangement of the gene encoding the highly homologous pulmonary surfactant apoprotein , although one of the intron positions is shifted by a single amino acid .", "entity": [{"entity": "MBP - A gene", "entity_type": "GENE", "pos": [24, 36]}, {"entity": "homologous pulmonary surfactant apoprotein", "entity_type": "GENE", "pos": [104, 146]}], "task": "NER"}
{"text": "Plasma renin activity in essential arterial hypertension .", "entity": [{"entity": "Plasma renin", "entity_type": "GENE", "pos": [0, 12]}], "task": "NER"}
{"text": "In vitro , cytokine - or hypoxia - induced up - regulation of Fas expression is associated with RTC apoptosis .", "entity": [{"entity": "Fas", "entity_type": "GENE", "pos": [62, 65]}], "task": "NER"}
{"text": "These results suggest that the Reg1 - Glc7 phosphatase is a cytoplasmic component of the machinery responsible for returning Snf1 kinase activity to its basal level and reestablishing glucose repression .", "entity": [{"entity": "Reg1", "entity_type": "GENE", "pos": [31, 35]}, {"entity": "Glc7", "entity_type": "GENE", "pos": [38, 42]}, {"entity": "Snf1 kinase", "entity_type": "GENE", "pos": [125, 136]}], "task": "NER"}
{"text": "To explore further the role of the carboxyl - terminal domain in determining the cell cycle function of CDC34 , we constructed and characterized genes encoding chimeric E2s incorporating sequences from CDC34 and the related but functionally distinct E2 RAD6 ( UBC2 ) .", "entity": [{"entity": "CDC34", "entity_type": "GENE", "pos": [104, 109]}, {"entity": "chimeric E2s", "entity_type": "GENE", "pos": [160, 172]}, {"entity": "CDC34", "entity_type": "GENE", "pos": [202, 207]}, {"entity": "E2", "entity_type": "GENE", "pos": [250, 252]}, {"entity": "RAD6", "entity_type": "GENE", "pos": [253, 257]}, {"entity": "UBC2", "entity_type": "GENE", "pos": [260, 264]}], "task": "NER"}
{"text": "In F9 , which is a prototype of embryonal carcinoma cells expressing hst , the expression of hst gene is positively regulated by a downstream octamer motif that functions as an enhancer .", "entity": [{"entity": "hst", "entity_type": "GENE", "pos": [69, 72]}, {"entity": "hst gene", "entity_type": "GENE", "pos": [93, 101]}], "task": "NER"}
{"text": "Furthermore , rubella IgM antibody was never detected after immunization in women who were HAI - negative and LA - positive during pregnancy .", "entity": [{"entity": "rubella IgM antibody", "entity_type": "GENE", "pos": [14, 34]}], "task": "NER"}
{"text": "Since simian virus 40 ( SV40 ) large T antigen and human papillomavirus type 16 ( HPV16 ) E7 protein also bind host regulatory factors , we investigated whether these viral proteins can complement E1A mutants which are defective in early gene activation .", "entity": [{"entity": "simian virus 40 ( SV40 ) large T antigen", "entity_type": "GENE", "pos": [6, 46]}, {"entity": "human papillomavirus type 16 ( HPV16 ) E7 protein", "entity_type": "GENE", "pos": [51, 100]}, {"entity": "E1A mutants", "entity_type": "GENE", "pos": [197, 208]}], "task": "NER"}
{"text": "Only viable bacteria at a high concentration induced purulent otitis media , which was culture positive in 58 % of the cases on day 4 .", "entity": [], "task": "NER"}
{"text": "Results indicated that hobbies / leisure activities , mobility , transport , social relationships , working capacity , energy and doing things slower were aspects relevant to IPF patients ' QOL .", "entity": [], "task": "NER"}
{"text": "Residues that affect PLCbeta and adenylyl cyclase II activity are found on opposite sides of the central tunnel , suggesting that PLC and adenylyl cyclase , like the alpha subunit , make many contacts on the top surface .", "entity": [{"entity": "PLCbeta", "entity_type": "GENE", "pos": [21, 28]}, {"entity": "adenylyl cyclase II", "entity_type": "GENE", "pos": [33, 52]}, {"entity": "PLC", "entity_type": "GENE", "pos": [130, 133]}, {"entity": "adenylyl cyclase", "entity_type": "GENE", "pos": [138, 154]}], "task": "NER"}
{"text": "One new ORF , YBR0224 , was detected , coding for a protein with 918 amino acids .", "entity": [{"entity": "YBR0224", "entity_type": "GENE", "pos": [14, 21]}], "task": "NER"}
{"text": "The law and the chiropractor .", "entity": [], "task": "NER"}
{"text": "A distinct 5 ' - sequence in clone hMIWC2 suggested an alternative upstream transcription initiation site .", "entity": [], "task": "NER"}
{"text": "Rectal temperatures after the walk were greater ( P < . 001 ) in native Simmental ( 39 . 87 + / - . 05 degrees C ) than in Bos indicus ( 39 . 46 + / - . 05 degrees C ) .", "entity": [], "task": "NER"}
{"text": "98 , 93 - 98 ) .", "entity": [], "task": "NER"}
{"text": "However , the pre3 - 2 mutation strengthened phenotypes induced by other 20 S proteasomal mutations , indicating that the peptidylglutamyl peptide - hydrolyzing activity has to fulfill some rescue functions .", "entity": [{"entity": "pre3 - 2 mutation", "entity_type": "GENE", "pos": [14, 31]}, {"entity": "20 S proteasomal mutations", "entity_type": "GENE", "pos": [73, 99]}], "task": "NER"}
{"text": "A mammalian protein called RFX or NF - X binds to the X box ( or X1 box ) in the promoters of a number of major histocompatibility ( MHC ) class II genes .", "entity": [{"entity": "RFX", "entity_type": "GENE", "pos": [27, 30]}, {"entity": "NF - X", "entity_type": "GENE", "pos": [34, 40]}, {"entity": "major histocompatibility ( MHC ) class II genes", "entity_type": "GENE", "pos": [106, 153]}], "task": "NER"}
{"text": "This result suggests that the target protein specificity of E2s can be altered by the addition of appropriate C - terminal extensions , thus providing a way to modify the selectivity of the ubiquitin system .", "entity": [{"entity": "E2s", "entity_type": "GENE", "pos": [60, 63]}, {"entity": "ubiquitin", "entity_type": "GENE", "pos": [190, 199]}], "task": "NER"}
{"text": "This pattern of expression and differential processing suggests a role for inrpk1 in some aspect of SD photoperiodic - induced flowering in morning glory .", "entity": [{"entity": "inrpk1", "entity_type": "GENE", "pos": [75, 81]}], "task": "NER"}
{"text": "Co - expression of a gag - TRalpha fusion protein in AEV - transformed cells and addition of ligand derepresses CAII transcription .", "entity": [{"entity": "gag", "entity_type": "GENE", "pos": [21, 24]}, {"entity": "TRalpha", "entity_type": "GENE", "pos": [27, 34]}, {"entity": "CAII", "entity_type": "GENE", "pos": [112, 116]}], "task": "NER"}
{"text": "A 400 - bp fragment ( bp - 339 through + 71 ) of the CD22 promoter region was subcloned into a pGEM - chloramphenicol acetyltransferase vector and after transfection into B and T cells was found to be active in both B and T cells .", "entity": [{"entity": "CD22 promoter region", "entity_type": "GENE", "pos": [53, 73]}, {"entity": "chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [102, 135]}], "task": "NER"}
{"text": "This suggests that the duration of varicocele per se could affect DHT seminal plasma levels .", "entity": [], "task": "NER"}
{"text": "Five RNA transcripts of about 1 . 2 to 1 . 7 kilobases were mapped to a part of the genome of insect iridescent virus type 6 ( Chilo iridescent virus ; CIV ) between genome coordinates 0 . 832 and 0 . 856 within the EcoRI DNA fragment F .", "entity": [{"entity": "EcoRI DNA fragment F", "entity_type": "GENE", "pos": [216, 236]}], "task": "NER"}
{"text": "Cutting the intraorbital nerves produced a temporary retrieval impairment that was indistinguishable from that produced by intramystacial lidocaine injection .", "entity": [], "task": "NER"}
{"text": "The comparisons of swimming performance before and after treatments with deltamethrin have shown a significant effect on locomotory ability of rainbow trout which at the end of strong exposure ( e . g .", "entity": [], "task": "NER"}
{"text": "Increased trabecular spacing , such as it occurs in osteoporosis , reduces the spatial field inhomogeneity and thus prolongs T2 * , which has been shown both in vitro and in vivo .", "entity": [], "task": "NER"}
{"text": "Decidual / trophoblast prolactin - related protein : characterization of gene structure and cell - specific expression .", "entity": [{"entity": "Decidual / trophoblast prolactin - related protein", "entity_type": "GENE", "pos": [0, 50]}], "task": "NER"}
{"text": "Thus , the cognitive performance of elderly subjects could be trained to a large extent .", "entity": [], "task": "NER"}
{"text": "The map is based on the CEPH reference pedigrees and includes over 4000 new genotypes , our previously reported data plus 29 allele systems from the published CEPH version 5 database , and was constructed using the program package CRI - MAP .", "entity": [], "task": "NER"}
{"text": "RMR was positively correlated with TEF ( r = 0 . 613 , p < 0 . 01 ) and net TEF ( r = 0 . 648 , p < 0 . 005 ) in the luteal but not the follicular phase .", "entity": [], "task": "NER"}
{"text": "132 varix ligations were performed during 44 separate EVL sessions .", "entity": [], "task": "NER"}
{"text": "Nine individuals who were stable after 1 month of therapy at low dosage were randomized to a further month of therapy at low or high dosage , during which one of four at high dosage had a partial response , and none of five at low dosage manifested response .", "entity": [], "task": "NER"}
{"text": "A factor present in nuclear extracts of wounded potato tubers was found to bind specifically to nucleotides located between - 135 to - 105 , suggesting that this region contains important cis - regulatory elements .", "entity": [], "task": "NER"}
{"text": "Two genes from the family encoding mouse ribosomal protein S16 were cloned , sequenced , and analyzed .", "entity": [{"entity": "mouse ribosomal protein S16", "entity_type": "GENE", "pos": [35, 62]}], "task": "NER"}
{"text": "Bile reflux demonstrated by 99m Tc disofenin .", "entity": [], "task": "NER"}
{"text": "The mode of action is often suggested as an explanation for the different slopes of concentration - effect curves .", "entity": [], "task": "NER"}
{"text": "Two full - length clones ( pBCH1 and pBCH2 ) were isolated .", "entity": [], "task": "NER"}
{"text": "In dehydrated animals at Ta 38 degrees C , Tb and EWL were both significantly altered ( P less than 0 . 001 ) from the normally hydrated state and were measured at 39 . 9 + / - 0 . 2 degree C and 0 . 84 + / - 0 . 09 W . kg - 1 respectively .", "entity": [], "task": "NER"}
{"text": "The optimum cooling rate from RT to 5 degrees C resulting in maximum survival of human spermatozoa was found to be 0 . 5 to 1 degree per minute when cooled from RT to 5 degrees C and subsequently frozen - thawed in liquid nitrogen ( LN2 ) .", "entity": [], "task": "NER"}
{"text": "Replacement of a valine ( V68 ) in the ETS domain of SAP1a by aspartic acid ( as found in c - Ets - 1 , Elk - 1 , and Net ) enhanced ternary complex formation by more than 60 - fold .", "entity": [{"entity": "ETS", "entity_type": "GENE", "pos": [39, 42]}, {"entity": "SAP1a", "entity_type": "GENE", "pos": [53, 58]}, {"entity": "c - Ets - 1", "entity_type": "GENE", "pos": [90, 101]}, {"entity": "Elk - 1", "entity_type": "GENE", "pos": [104, 111]}, {"entity": "Net", "entity_type": "GENE", "pos": [118, 121]}], "task": "NER"}
{"text": "Methylprednisolone and U - 74006F were equally effective at preventing neurological dysfunction compared to the control group ( p less than 0 . 01 ) ; U - 78517F was slightly less effective than U - 74006F and methylprednisolone but was significantly better than vehicle in preventing neurological dysfunction .", "entity": [], "task": "NER"}
{"text": "Comparison between the Ricketts and Bimler therapeutic technics in the treatment of cases of class II , division I mmalocclusion", "entity": [], "task": "NER"}
{"text": "Sample size requirement for repeated measurements in continuous data .", "entity": [], "task": "NER"}
{"text": "Transfection assays using the first 600 bp of the upstream nucleotide sequences indicated that a region from - 75 to - 120 was necessary for the ALDH2 gene expression , and especially NF - Y / CP1 binding site from - 92 to - 96 ( CCAAT box ) is important in the expression of the gene .", "entity": [{"entity": "ALDH2 gene", "entity_type": "GENE", "pos": [145, 155]}, {"entity": "NF - Y", "entity_type": "GENE", "pos": [184, 190]}, {"entity": "CP1", "entity_type": "GENE", "pos": [193, 196]}], "task": "NER"}
{"text": "We report five of 13 evaluable patients undergoing allogeneic sibling BM or PBSC transplantation for MM between 1990 and 1997 who met the criteria for adjuvant alpha - IFN therapy .", "entity": [{"entity": "alpha - IFN", "entity_type": "GENE", "pos": [160, 171]}], "task": "NER"}
{"text": "Both the 5 ' and 3 ' untranslated regions also show significant similarity to the murine gene , with 79 and 70 % sequence identity , respectively .", "entity": [], "task": "NER"}
{"text": "Plasma Pi , tibia breaking strength , and percentage of tibia ash were increased by raising dietary Pav in the presence of . 392 % A1 with either level of Ca .", "entity": [], "task": "NER"}
{"text": "A minimal region which stimulates origin function mapped to 50 amino acids within the C - terminus of Abf1p .", "entity": [{"entity": "Abf1p", "entity_type": "GENE", "pos": [102, 107]}], "task": "NER"}
{"text": "Hepatocyte growth factor ( HGF ) is an inducible cytokine that is essential for the normal growth and development of various tissues , such as the liver .", "entity": [{"entity": "Hepatocyte growth factor", "entity_type": "GENE", "pos": [0, 24]}, {"entity": "HGF", "entity_type": "GENE", "pos": [27, 30]}], "task": "NER"}
{"text": "OBJECTIVE : To summarise quantitatively the association between moderate alcohol intake and biological markers of risk of coronary heart disease and to predict how these changes would lower the risk .", "entity": [], "task": "NER"}
{"text": "( 1991 ) EMBO J .", "entity": [], "task": "NER"}
{"text": "Tissue - specific gene regulation of eukaryotic organisms is to a large extent mediated by transcription factors that interact with genomic DNA sequences in a sequence - specific manner .", "entity": [], "task": "NER"}
{"text": "Teratospermia is therefore an important factor in evaluating fertilization capacity .", "entity": [], "task": "NER"}
{"text": "Genomic DNA blot analysis indicates that the trout L2 locus has a cluster - like organization similar to the trout L1 locus and the IgL locus of several teleost fish .", "entity": [{"entity": "trout L2 locus", "entity_type": "GENE", "pos": [45, 59]}, {"entity": "trout L1 locus", "entity_type": "GENE", "pos": [109, 123]}, {"entity": "IgL locus", "entity_type": "GENE", "pos": [132, 141]}], "task": "NER"}
{"text": "Genetic polymorphisms in the 5 ' - flanking region change transcriptional regulation of the human cytochrome P450IIE1 gene .", "entity": [{"entity": "human cytochrome P450IIE1 gene", "entity_type": "GENE", "pos": [92, 122]}], "task": "NER"}
{"text": "As exogenously expressed PKR can form heterodimers with endogenous PKR , the results obtained on the functional characterization of mutant forms of PKR have been taken with caution .", "entity": [{"entity": "PKR", "entity_type": "GENE", "pos": [25, 28]}, {"entity": "endogenous PKR", "entity_type": "GENE", "pos": [56, 70]}, {"entity": "PKR", "entity_type": "GENE", "pos": [148, 151]}], "task": "NER"}
{"text": "Basal JNK MAPK kinase activity was also specifically induced by deltaEGFR , which correlated with increased phosphorylation of a 54 - kDa JNK2 protein observed in deltaEGFR - containing cells .", "entity": [{"entity": "JNK MAPK kinase", "entity_type": "GENE", "pos": [6, 21]}, {"entity": "deltaEGFR", "entity_type": "GENE", "pos": [64, 73]}, {"entity": "54 - kDa JNK2 protein", "entity_type": "GENE", "pos": [129, 150]}, {"entity": "deltaEGFR", "entity_type": "GENE", "pos": [163, 172]}], "task": "NER"}
{"text": "Isolation and properties of Drosophila melanogaster ferritin - - molecular cloning of a cDNA that encodes one subunit , and localization of the gene on the third chromosome .", "entity": [{"entity": "Drosophila melanogaster ferritin", "entity_type": "GENE", "pos": [28, 60]}], "task": "NER"}
{"text": "The single - copy U20 sequence is located on the same DNA strand as the nucleolin mRNA .", "entity": [{"entity": "U20 sequence", "entity_type": "GENE", "pos": [18, 30]}, {"entity": "nucleolin mRNA", "entity_type": "GENE", "pos": [72, 86]}], "task": "NER"}
{"text": "Maximum baroreceptor activity measured at 140 mm Hg and the slope of the pressure - activity curve were reduced in atherosclerotic ( n = 15 ) compared with normal ( n = 13 ) rabbits ( 425 + / - 34 versus 721 + / - 30 spikes per second and 6 . 2 + / - 0 . 6 versus 10 . 8 + / - 0 . 8 spikes per second per mm Hg , respectively , P < . 05 ) .", "entity": [], "task": "NER"}
{"text": "The effective use of superoxide dismutase from human erythrocytes in the late stages of experimental influenza infection", "entity": [{"entity": "superoxide dismutase", "entity_type": "GENE", "pos": [21, 41]}], "task": "NER"}
{"text": "EMT was localized to chromosome 5q31 - 32 , a region that contains the genes for several growth factors and receptors as well as early activation genes , particularly those involved in the hematopoietic system .", "entity": [{"entity": "EMT", "entity_type": "GENE", "pos": [0, 3]}], "task": "NER"}
{"text": "However , neither SF - 1 nor NGF - IB alone , binding as monomers , increases transcription .", "entity": [{"entity": "SF - 1", "entity_type": "GENE", "pos": [18, 24]}, {"entity": "NGF - IB", "entity_type": "GENE", "pos": [29, 37]}], "task": "NER"}
{"text": "Both purH and purD genes constitute a single operon and are coregulated in expression by purines as other purine genes are .", "entity": [{"entity": "purH", "entity_type": "GENE", "pos": [5, 9]}, {"entity": "purD genes", "entity_type": "GENE", "pos": [14, 24]}, {"entity": "purine genes", "entity_type": "GENE", "pos": [106, 118]}], "task": "NER"}
{"text": "Fluorescence in situ hybridization was used to investigate the physical distribution and revealed that both retrotransposon families are present on all sugar beet chromosomes and largely excluded from chromosomal regions harbouring the 18S - 5 . 8S - 25S rRNA genes .", "entity": [{"entity": "18S", "entity_type": "GENE", "pos": [236, 239]}, {"entity": "5 . 8S", "entity_type": "GENE", "pos": [242, 248]}, {"entity": "25S", "entity_type": "GENE", "pos": [251, 254]}], "task": "NER"}
{"text": "Application of the method using an 11 - year microseismicity record revealed systematic spatial and temporal changes in the slip rate that were synchronous with earthquake activity and other independent measures of fault - zone slip .", "entity": [], "task": "NER"}
{"text": "Furthermore , we have identified the major open reading frame ( RF4 ; 2 . 3 kb ) as being essential for activation , and we have shown that the NF kappa B , SP1 , and TATA box motifs in the human immunodeficiency virus LTR are all required for full induction of the promoter by the HHV - 6 - encoded transactivator .", "entity": [{"entity": "NF kappa B", "entity_type": "GENE", "pos": [144, 154]}, {"entity": "SP1", "entity_type": "GENE", "pos": [157, 160]}, {"entity": "human immunodeficiency virus LTR", "entity_type": "GENE", "pos": [190, 222]}, {"entity": "HHV - 6 - encoded transactivator", "entity_type": "GENE", "pos": [282, 314]}], "task": "NER"}
{"text": "Two conserved motifs , W89RKRRY94 and P156KKIKP161 , seemed to act as nuclear addressing signals .", "entity": [], "task": "NER"}
{"text": "All testosterone treatments raised plasma testosterone concentrations above control and pretreatment levels ( testosterone and synovex + testosterone > synovex > control ; all P < 0 . 05 ) .", "entity": [], "task": "NER"}
{"text": "The educational program was the significant factor that influenced the change of concern trajectories , and the recurrent / non - recurrent factor influenced the change of concern only in pamphlet group .", "entity": [], "task": "NER"}
{"text": "Snails infected with three or five miracidia produced more metacercariae than those infected with a single miracidium .", "entity": [], "task": "NER"}
{"text": "Evidence that the AT1A receptor activates transcription factor - Stat91 and / or a related protein .", "entity": [{"entity": "AT1A receptor", "entity_type": "GENE", "pos": [18, 31]}, {"entity": "transcription factor - Stat91", "entity_type": "GENE", "pos": [42, 71]}], "task": "NER"}
{"text": "Two estimates of the fractal exponent are considered which do not suffer from this limit : one derived from the Allan variance , which was developed by the authors , and one based on the periodogram .", "entity": [], "task": "NER"}
{"text": "The full - length cDNA was cloned and sequenced , and the inferred amino acid sequence was found to encode a novel protein , which we named cystatin M , with 40 % homology to human family 2 cystatins and similar overall structure .", "entity": [{"entity": "cystatin M", "entity_type": "GENE", "pos": [140, 150]}, {"entity": "human family 2 cystatins", "entity_type": "GENE", "pos": [175, 199]}], "task": "NER"}
{"text": "Thus , oxyR mutants are locked on for Ag43 expression , whereas dam mutants are locked off for Ag43 expression .", "entity": [{"entity": "oxyR mutants", "entity_type": "GENE", "pos": [7, 19]}, {"entity": "Ag43", "entity_type": "GENE", "pos": [38, 42]}, {"entity": "dam mutants", "entity_type": "GENE", "pos": [64, 75]}, {"entity": "Ag43", "entity_type": "GENE", "pos": [95, 99]}], "task": "NER"}
{"text": "GH induced rapid tyrosine phosphorylation of a protein at approximately 93 kDa in normal fibroblasts , and Western blotting with STAT - specific antibodies revealed STAT5 activation ( phosphorylation ) by GH .", "entity": [{"entity": "GH", "entity_type": "GENE", "pos": [0, 2]}, {"entity": "STAT - specific antibodies", "entity_type": "GENE", "pos": [129, 155]}, {"entity": "STAT5", "entity_type": "GENE", "pos": [165, 170]}], "task": "NER"}
{"text": "The team physician and conditioning of athletes for sports : a consensus statement .", "entity": [], "task": "NER"}
{"text": "Experimental exposure of poults with each of two strains representing the rarely reported capsular group B indicated that both were virulent .", "entity": [], "task": "NER"}
{"text": "A drop of methylprednisolone acetate or vehicle constituent was placed on the dissected plantar nerve proximal to the stimulating electrodes after recording control responses ( A - fibre volley in the sciatic nerve and C - fibre evoked reflex discharge in flexor motoneurons ) .", "entity": [], "task": "NER"}
{"text": "Case of nephrotic syndrome caused by gold preparations", "entity": [], "task": "NER"}
{"text": "Pax - 6 constructs lacking the C - terminal activation domain repressed betaB1 - crystallin promoter activity as effectively as the full - length protein , but the PD alone or Pax - 6 ( 5a ) , a splice variant with an altered PD affecting its DNA binding specificity , did not .", "entity": [{"entity": "Pax - 6", "entity_type": "GENE", "pos": [0, 7]}, {"entity": "betaB1 - crystallin promoter", "entity_type": "GENE", "pos": [72, 100]}, {"entity": "PD", "entity_type": "GENE", "pos": [164, 166]}, {"entity": "Pax - 6 ( 5a )", "entity_type": "GENE", "pos": [176, 190]}, {"entity": "PD", "entity_type": "GENE", "pos": [226, 228]}], "task": "NER"}
{"text": "It is considered important , therefore , when treating diabetic patients with peripheral neuropathy not to assume that the diabetes itself is the cause in all cases .", "entity": [], "task": "NER"}
{"text": "A retrospective study of clozapine and electroencephalographic abnormalities in schizophrenic patients .", "entity": [], "task": "NER"}
{"text": "While working on the toxicity of war gases . he formulated ' Haber ' s rule ' , also known as C x T = constant in order to characterize the toxicity of an inhalant .", "entity": [], "task": "NER"}
{"text": "Furthermore , the regulation conferred on a reporter gene in Drosophila by three closely related sequences demonstrates that even subtle sequence changes within an E box or flanking bases have dramatic consequences on the overall repertoire of proteins that can bind in vivo .", "entity": [], "task": "NER"}
{"text": "The Sensititre MIC panels containing meropenem offer a convenient and valid alternative to the NCCLS reference method for the susceptibility testing of potential pathogens likely to be recovered from mixed infections .", "entity": [], "task": "NER"}
{"text": "Two putative ATP - binding domains were identified , one in the amino - terminal half of the argA - encoded protein and the other in the carboxy - terminal half .", "entity": [{"entity": "argA - encoded protein", "entity_type": "GENE", "pos": [93, 115]}], "task": "NER"}
{"text": "Previously , we identified two human SMC family proteins , hCAP - C and hCAP - E , which form a heterodimeric complex ( hCAP - C - hCAP - E ) in the cell .", "entity": [{"entity": "human SMC family proteins", "entity_type": "GENE", "pos": [31, 56]}, {"entity": "hCAP - C", "entity_type": "GENE", "pos": [59, 67]}, {"entity": "hCAP - E", "entity_type": "GENE", "pos": [72, 80]}, {"entity": "hCAP - C", "entity_type": "GENE", "pos": [120, 128]}, {"entity": "hCAP - E", "entity_type": "GENE", "pos": [131, 139]}], "task": "NER"}
{"text": "There were no major postoperative complications and at follow - up of the 13 patients at 10 to 26 months after operation the results were satisfactory .", "entity": [], "task": "NER"}
{"text": "The interleukin - 2 receptor alpha ( IL - 2R alpha ) chain gene contains a sequence similar to the immunoglobulin ( Ig ) kappa ( kappa ) enhancer NF - kappa B binding site .", "entity": [{"entity": "interleukin - 2 receptor alpha", "entity_type": "GENE", "pos": [4, 34]}, {"entity": "IL - 2R alpha", "entity_type": "GENE", "pos": [37, 50]}, {"entity": "immunoglobulin ( Ig ) kappa", "entity_type": "GENE", "pos": [99, 126]}, {"entity": "NF - kappa B binding site", "entity_type": "GENE", "pos": [146, 171]}], "task": "NER"}
{"text": "( 1996 ) J .", "entity": [], "task": "NER"}
{"text": "The presence of a short ( 70 bp ) intron near the N - terminus of the atX gene was predicted that contains the canonical GT and AG dinucleotides at its 5 ' - and 3 ' - splicing junctions .", "entity": [{"entity": "atX gene", "entity_type": "GENE", "pos": [70, 78]}], "task": "NER"}
{"text": "Studies on the reaction of cytochrome c with corticosteroids .", "entity": [{"entity": "cytochrome c", "entity_type": "GENE", "pos": [27, 39]}], "task": "NER"}
{"text": "In accordance with Ann Arbor classification , we observed 12 CS IA ( 21 . 3 % ) , 2 CS IB ( 3 . 5 % ) , 14 CS IIA ( 25 . 4 % ) and 27 CS IIB ( 49 . 7 % ) .", "entity": [], "task": "NER"}
{"text": "The results can be summarized as follows .", "entity": [], "task": "NER"}
{"text": "The level of expression of the PDE protein was monitored by immunoblot analysis using two specific cAMP - PDE polyclonal antibodies and by measuring the PDE activity .", "entity": [{"entity": "PDE protein", "entity_type": "GENE", "pos": [31, 42]}, {"entity": "cAMP - PDE polyclonal antibodies", "entity_type": "GENE", "pos": [99, 131]}, {"entity": "PDE", "entity_type": "GENE", "pos": [153, 156]}], "task": "NER"}
{"text": "HL is hypothesized to directly couple HDL lipid metabolism to tissue / cellular lipid metabolism .", "entity": [{"entity": "HL", "entity_type": "GENE", "pos": [0, 2]}, {"entity": "HDL", "entity_type": "GENE", "pos": [38, 41]}], "task": "NER"}
{"text": "The analysis of the organization of the sequence of the human ABP / DAO gene reveals that the 2 . 4 - kilobase messenger RNA is transcribed from two close origins identifying the proximal promoter .", "entity": [{"entity": "ABP", "entity_type": "GENE", "pos": [62, 65]}, {"entity": "DAO", "entity_type": "GENE", "pos": [68, 71]}], "task": "NER"}
{"text": "Rottlerin also inhibited the activation of MAP kinase kinase ( MEK ) in response to activated Raf , but had no effect upon c - Raf activity or ERK activation by activated MEK .", "entity": [{"entity": "MAP kinase kinase", "entity_type": "GENE", "pos": [43, 60]}, {"entity": "MEK", "entity_type": "GENE", "pos": [63, 66]}, {"entity": "Raf", "entity_type": "GENE", "pos": [94, 97]}, {"entity": "c - Raf", "entity_type": "GENE", "pos": [123, 130]}, {"entity": "ERK", "entity_type": "GENE", "pos": [143, 146]}, {"entity": "MEK", "entity_type": "GENE", "pos": [171, 174]}], "task": "NER"}
{"text": "Especially if the number of dimensions of the samples is large , it can be said that BPN is better than k - NN in classification ability .", "entity": [], "task": "NER"}
{"text": "Several DNA clones were obtained by this procedure , one of which , clone 18 , is reported and characterized here .", "entity": [], "task": "NER"}
{"text": "Immunoprecipitation of cell lysates with anti - phosphotyrosine and immunoblotting showed phosphorylated forms of the mitogenic pathway proteins Shc and MAPK in addition to p185 ( neu ) , suggesting that the Ras to MAPK mitogenic pathway is activated .", "entity": [{"entity": "anti - phosphotyrosine", "entity_type": "GENE", "pos": [41, 63]}, {"entity": "Shc", "entity_type": "GENE", "pos": [145, 148]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [153, 157]}, {"entity": "p185", "entity_type": "GENE", "pos": [173, 177]}, {"entity": "neu", "entity_type": "GENE", "pos": [180, 183]}, {"entity": "Ras", "entity_type": "GENE", "pos": [208, 211]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [215, 219]}], "task": "NER"}
{"text": "The sequence immediately upstream of the translation start site was G + C rich ( greater than 75 % ) and contained a consensus CCAAT sequence despite the absence of a TATA box .", "entity": [], "task": "NER"}
{"text": "The development of various pathological lesions in thymus , spleen , lymph nodes and bone - marrow is frequently observed .", "entity": [], "task": "NER"}
{"text": "RESULTS : After 3 weeks of therapy , the patient had an increase in platelet count from a baseline of 5 , 000 to 8 , 000 / microliter to a maximal level of 33 , 000 / microliter .", "entity": [], "task": "NER"}
{"text": "In the latter , the cells and adjacent matrix had several characteristics of fibrocartilage , including chondrocytes .", "entity": [], "task": "NER"}
{"text": "Radiation sensitivity of rats irradiated in a condition of hypoxia", "entity": [], "task": "NER"}
{"text": "When the opioid antagonist was administered to animals 24 hr after termination of single or multiple exposures to restraint , NALT - induced increases in basal plasma LH were significantly attenuated in the chronically stressed rats compared to animals subjected to stress only once or not at all . ( ABSTRACT TRUNCATED AT 250 WORDS )", "entity": [{"entity": "plasma LH", "entity_type": "GENE", "pos": [160, 169]}], "task": "NER"}
{"text": "Furthermore , CBP / p300 stimulated both TGF - beta - and Smad - induced transcription in a Smad4 / DPC4 - dependent fashion .", "entity": [{"entity": "CBP", "entity_type": "GENE", "pos": [14, 17]}, {"entity": "p300", "entity_type": "GENE", "pos": [20, 24]}, {"entity": "TGF - beta", "entity_type": "GENE", "pos": [41, 51]}, {"entity": "Smad", "entity_type": "GENE", "pos": [58, 62]}, {"entity": "Smad4", "entity_type": "GENE", "pos": [92, 97]}, {"entity": "DPC4", "entity_type": "GENE", "pos": [100, 104]}], "task": "NER"}
{"text": "Analysis of exon 2 of the factor IX gene revealed a C - - > T mutation in codon 10 of the propeptide region , resulting in the substitution of alanine by valine .", "entity": [{"entity": "factor IX gene", "entity_type": "GENE", "pos": [26, 40]}], "task": "NER"}
{"text": "In contrast to the restricted tissue expression of gonadotropin and TSH receptors in gonads and thyroid , respectively , LGR4 is expressed in diverse tissues including ovary , testis , adrenal , placenta , thymus , spinal cord , and thyroid , whereas LGR5 is found in muscle , placenta , spinal cord , and brain .", "entity": [{"entity": "gonadotropin", "entity_type": "GENE", "pos": [51, 63]}, {"entity": "TSH receptors", "entity_type": "GENE", "pos": [68, 81]}, {"entity": "LGR4", "entity_type": "GENE", "pos": [121, 125]}, {"entity": "LGR5", "entity_type": "GENE", "pos": [251, 255]}], "task": "NER"}
{"text": "We now show that purified recombinant c - sis / PDGF can induce this binding activity which we have termed SIF , for sis - inducible factor .", "entity": [{"entity": "c - sis", "entity_type": "GENE", "pos": [38, 45]}, {"entity": "PDGF", "entity_type": "GENE", "pos": [48, 52]}, {"entity": "SIF", "entity_type": "GENE", "pos": [107, 110]}, {"entity": "sis - inducible factor", "entity_type": "GENE", "pos": [117, 139]}], "task": "NER"}
{"text": "Antinuclear antibodies , rheumatoid factor and C - reactive protein in serum of normal women using oral contraceptives .", "entity": [{"entity": "rheumatoid factor", "entity_type": "GENE", "pos": [25, 42]}, {"entity": "C - reactive protein", "entity_type": "GENE", "pos": [47, 67]}], "task": "NER"}
{"text": "We report here that AChE activity tends to decrease in individuals sampled in tanks at a salinity of 30 per thousand as temperature increases .", "entity": [{"entity": "AChE", "entity_type": "GENE", "pos": [20, 24]}], "task": "NER"}
{"text": "The relationship between donor status for antibody to hepatitis B core antigen and the occurrence of non - A , non - B posttransfusion hepatitis in the recipient was prospectively studied in 112 patients undergoing open - heart surgery who were followed for 6 . 5 months after surgery .", "entity": [{"entity": "hepatitis B core antigen", "entity_type": "GENE", "pos": [54, 78]}], "task": "NER"}
{"text": "Both control and Mn - exposed quail accumulated 5 to 10 times more Mn in their livers than similarly treated rodents .", "entity": [], "task": "NER"}
{"text": "These data suggested that mutant PS1 may cause disease as a result of reduction in PS1 function .", "entity": [{"entity": "mutant PS1", "entity_type": "GENE", "pos": [26, 36]}, {"entity": "PS1", "entity_type": "GENE", "pos": [83, 86]}], "task": "NER"}
{"text": "In response to phosphorus limitation , the fungus Neurospora crassa synthesizes a number of enzymes that function to bring more phosphate into the cell .", "entity": [], "task": "NER"}
{"text": "IL - 6 was detected in the urine of 52 % of children with pyelonephritis compared with 15 % of other children ( P < 0 . 001 ) .", "entity": [{"entity": "IL - 6", "entity_type": "GENE", "pos": [0, 6]}], "task": "NER"}
{"text": "The effects of pretreatment with the non - competitive NMDA antagonist ( + ) MK - 801 on the behavioral alterations induced by repeated restraint stress were investigated .", "entity": [], "task": "NER"}
{"text": "Radiation was delivered in a single 4 - mJ pulse of 200 microseconds duration by means of an articulated zirconium fluoride optical fibre and a 320 - microns quartz - fibre tip .", "entity": [], "task": "NER"}
{"text": "MsEPV genes with putative functions in prevention and repair of DNA damage include a complete base excision repair pathway ( uracil DNA glycosylase , AP endonuclease , DNA polymerase beta , and an NAD + - dependent DNA ligase ) , a photoreactivation repair pathway ( cyclobutane pyrimidine dimer photolyase ) , a LINE - type reverse transcriptase , and a mutT homologue .", "entity": [{"entity": "uracil DNA glycosylase", "entity_type": "GENE", "pos": [125, 147]}, {"entity": "AP endonuclease", "entity_type": "GENE", "pos": [150, 165]}, {"entity": "DNA polymerase beta", "entity_type": "GENE", "pos": [168, 187]}, {"entity": "NAD + - dependent DNA ligase", "entity_type": "GENE", "pos": [197, 225]}, {"entity": "cyclobutane pyrimidine dimer photolyase", "entity_type": "GENE", "pos": [267, 306]}, {"entity": "LINE - type reverse transcriptase", "entity_type": "GENE", "pos": [313, 346]}, {"entity": "mutT homologue", "entity_type": "GENE", "pos": [355, 369]}], "task": "NER"}
{"text": "In isolated olfactory cilia certain odorants elicit a rapid and transient cAMP response , terminated by a concerted process which requires the action of two protein kinases , protein kinase A ( PKA ) and a receptor - specific kinase ( GRK3 ) ( Schleicher , S . , Boekhoff , I .", "entity": [{"entity": "protein kinase A", "entity_type": "GENE", "pos": [175, 191]}, {"entity": "PKA", "entity_type": "GENE", "pos": [194, 197]}, {"entity": "receptor - specific kinase", "entity_type": "GENE", "pos": [206, 232]}, {"entity": "GRK3", "entity_type": "GENE", "pos": [235, 239]}], "task": "NER"}
{"text": "The results corroborate the proposed physiological function of CCoAOMT in elicited plant cells and may shed new light on the sequential action of trans - active factors in the regulation of phenylpropanoid genes .", "entity": [{"entity": "CCoAOMT", "entity_type": "GENE", "pos": [63, 70]}], "task": "NER"}
{"text": "Two hundred and eighty - three patients , 217 females ( median age 24 years , range 0 . 5 - 73 ) and 66 males ( median age 20 years , range 0 . 75 - 72 ) , were examined .", "entity": [], "task": "NER"}
{"text": "Pneumatic dilation of the lower esophageal sphincter was accomplished by endoscopic visualization and positioning of a modified polyurethane dilator ( 90 F diameter ) without fluoroscopy in 17 consecutive patients with advanced symptomatic achalasia .", "entity": [], "task": "NER"}
{"text": "The organotins .", "entity": [], "task": "NER"}
{"text": "A series of mutations were constructed within the E2 open reading frame which delete various regions of the conserved DNA binding and transactivation domains as well as the internal hinge region .", "entity": [{"entity": "E2", "entity_type": "GENE", "pos": [50, 52]}], "task": "NER"}
{"text": "These data indicate that chromatic processing in areas V1 and V2 is normal after V4 lesions and , together with the behavioural evidence , that these areas are sufficient for some basic aspects of colour perception .", "entity": [], "task": "NER"}
{"text": "The Cryotherapy for Retinopathy of Prematurity Study has shown that this number can be halved with treatment .", "entity": [], "task": "NER"}
{"text": "The non - major histocompatibility complex ( MHC ) - encoded CD1 family has recently emerged as a new antigen - presenting system that is distinct from either MHC class I or class II molecules .", "entity": [{"entity": "non - major histocompatibility complex", "entity_type": "GENE", "pos": [4, 42]}, {"entity": "MHC", "entity_type": "GENE", "pos": [45, 48]}, {"entity": "CD1 family", "entity_type": "GENE", "pos": [61, 71]}, {"entity": "MHC class I or class II molecules", "entity_type": "GENE", "pos": [159, 192]}], "task": "NER"}
{"text": "Nitroglycerin ( glyceryl trinitrate ) as a monoamine oxidase inhibitor .", "entity": [{"entity": "monoamine oxidase", "entity_type": "GENE", "pos": [43, 60]}], "task": "NER"}
{"text": "Doxazosin produced increases in both mean and maximum urinary flow rates of 1 . 01 ml / s and 3 . 2 ml / s respectively , compared with 0 . 21 ml / s and 2 . 2 ml / s on placebo .", "entity": [], "task": "NER"}
{"text": "We determined the complete nucleotide sequence of the gypsy element present at the forked locus of Drosophila melanogaster in the f1 allele .", "entity": [{"entity": "gypsy element", "entity_type": "GENE", "pos": [54, 67]}, {"entity": "forked locus", "entity_type": "GENE", "pos": [83, 95]}], "task": "NER"}
{"text": "Cloning and nucleotide sequence analysis reveals that BUR6 encodes a homolog of DRAP1 ( also called NC2alpha ) , a mammalian repressor of basal transcription .", "entity": [{"entity": "BUR6", "entity_type": "GENE", "pos": [54, 58]}, {"entity": "DRAP1", "entity_type": "GENE", "pos": [80, 85]}, {"entity": "NC2alpha", "entity_type": "GENE", "pos": [100, 108]}], "task": "NER"}
{"text": "The ATF / CRE site is also essential for CD4 promoter activation by forskolin , an activator of adenylate cyclase .", "entity": [{"entity": "ATF", "entity_type": "GENE", "pos": [4, 7]}, {"entity": "CD4 promoter", "entity_type": "GENE", "pos": [41, 53]}, {"entity": "adenylate cyclase", "entity_type": "GENE", "pos": [96, 113]}], "task": "NER"}
{"text": "These results point towards post - translational steric and / or allosteric control of EKLF function that may be important not just for its DNA binding ability , but also for its potential to interact with other proteins that fully establish the correct stereospecific array leading to efficient switching of beta - globin transcription during development .", "entity": [{"entity": "EKLF", "entity_type": "GENE", "pos": [87, 91]}, {"entity": "beta - globin", "entity_type": "GENE", "pos": [309, 322]}], "task": "NER"}
{"text": "They are growth - inhibited by TGF - beta1 .", "entity": [{"entity": "TGF - beta1", "entity_type": "GENE", "pos": [31, 42]}], "task": "NER"}
{"text": "Chronic active hepatitis and cirrhosis of the liver .", "entity": [], "task": "NER"}
{"text": "Colonization increased with level of care : from 9 per cent in independent residents of apartments to 60 per cent in patients on an acute hospital ward ( P less than 0 . 0001 ) .", "entity": [], "task": "NER"}
{"text": "Interaction of the v - rel protein with an NF - kappa B DNA binding site .", "entity": [{"entity": "v - rel protein", "entity_type": "GENE", "pos": [19, 34]}, {"entity": "NF - kappa B DNA binding site", "entity_type": "GENE", "pos": [43, 72]}], "task": "NER"}
{"text": "CVO2 saturation is a reliable and sensitive method for detecting blood loss .", "entity": [], "task": "NER"}
{"text": "In the Saccharomyces cerevisiae actin intron a silent branch point - like sequence ( UACUAAG ) is located 7 nt upstream of the canonical sequence .", "entity": [{"entity": "Saccharomyces cerevisiae actin intron", "entity_type": "GENE", "pos": [7, 44]}], "task": "NER"}
{"text": "The elevated levels of inositol phosphates resulting from N ( epi ) alpha qQ209L expression were similar to those obtained with carbachol activation of the M1 muscarinic acetylcholine receptor .", "entity": [{"entity": "N ( epi ) alpha qQ209L", "entity_type": "GENE", "pos": [58, 80]}, {"entity": "M1 muscarinic acetylcholine receptor", "entity_type": "GENE", "pos": [156, 192]}], "task": "NER"}
{"text": "To increase the number of circulating polymorphonuclear neutrophils , the patient was treated with recombinant granulocyte - macrophage colony - stimulating factor ( GM - CSF ) at a dose of 2 micrograms protein / kg bodyweight s . c . / 12 h .", "entity": [{"entity": "granulocyte - macrophage colony - stimulating factor", "entity_type": "GENE", "pos": [111, 163]}, {"entity": "GM - CSF", "entity_type": "GENE", "pos": [166, 174]}], "task": "NER"}
{"text": "PrRP rapidly and transiently activated extracellular signal - regulated protein kinase ( ERK ) in both types of cells .", "entity": [{"entity": "PrRP", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "extracellular signal - regulated protein kinase", "entity_type": "GENE", "pos": [39, 86]}, {"entity": "ERK", "entity_type": "GENE", "pos": [89, 92]}], "task": "NER"}
{"text": "Nevertheless , PEG influenced in vitro drug availability considerably , by increasing both drug solubility and dissolution rate .", "entity": [], "task": "NER"}
{"text": "Reversible topology of a bifunctional transmembrane protein depends upon the charge balance around its transmembrane domain .", "entity": [], "task": "NER"}
{"text": "We have documented previously that glucocorticoid hormones modulate the posttranslational localization of cell surface mouse mammary tumor virus ( MMTV ) glycoproteins in the viral - infected M1 . 54 rat HTC hepatoma cell line .", "entity": [], "task": "NER"}
{"text": "Contrast radiography appears to be an especially inaccurate method to document PUD in CF because the duodenal mucosa typically appears nodular and distorted with poor definition of the mucosal folds .", "entity": [], "task": "NER"}
{"text": "Spodoptera frugiperda ( Sf9 ) cells have proved a suitable cell system in which to study this association and to produce recombinant CR3 , and we show here that another lepidopteran cell line , Trichoplusia niTN - 5B1 - 4 ( High - Five ) cells , allows the recovery of large amounts of functional recombinant CR3 .", "entity": [{"entity": "recombinant CR3", "entity_type": "GENE", "pos": [121, 136]}, {"entity": "functional recombinant CR3", "entity_type": "GENE", "pos": [286, 312]}], "task": "NER"}
{"text": "Using the standard scoring , children with full scale IQ < or = 84 on the Wechsler Preschool and Primary Scale of Intelligence at age 4 - 5 years were poorly identified ( sensitivity 54 % ) from the composite S - B IV score at age 3 .", "entity": [], "task": "NER"}
{"text": "The relation between the changes of bone density and the level of blood calcium , blood phosphorus and alkaline phosphatase ( AKP ) as well as the metabolism of vitamin D was studied .", "entity": [{"entity": "alkaline phosphatase", "entity_type": "GENE", "pos": [103, 123]}, {"entity": "AKP", "entity_type": "GENE", "pos": [126, 129]}], "task": "NER"}
{"text": "To clarify the mechanisms that regulate transcription of the GTP cyclohydrolase I gene and to generate multiple species of mRNA , we isolated genomic DNA clones for the human and mouse GTP cyclohydrolase I genes .", "entity": [{"entity": "GTP cyclohydrolase I gene", "entity_type": "GENE", "pos": [61, 86]}, {"entity": "GTP cyclohydrolase I genes", "entity_type": "GENE", "pos": [185, 211]}], "task": "NER"}
{"text": "Perception of sweetness cannot be used to accurately meter the metabolizable energy or nutritive value of a food .", "entity": [], "task": "NER"}
{"text": "These results suggest that termination is a highly specific event , and not merely a consequence of decreased stability of the EC .", "entity": [], "task": "NER"}
{"text": "All sows nursed nine pigs .", "entity": [], "task": "NER"}
{"text": "When labeled by the described method , 99mTc on DTPA coupled antibodies shows instability in serum but superior stability than 99mTc on antibodies without the attached DTPA .", "entity": [], "task": "NER"}
{"text": "The crystal structure of the yeast Phe - tRNAPhe ternary complex with Thermus aquaticus EF - Tu - GDPNP ( Phe - TC ) has previously been determined as one representative of this general yet highly discriminating complex formation .", "entity": [{"entity": "Phe - tRNAPhe ternary complex", "entity_type": "GENE", "pos": [35, 64]}, {"entity": "EF - Tu", "entity_type": "GENE", "pos": [88, 95]}, {"entity": "Phe - TC", "entity_type": "GENE", "pos": [106, 114]}], "task": "NER"}
{"text": "Our results indicate that GCN4 contains two activation domains of similar potency that can function independently to promote high - level transcription of the target genes HIS3 and HIS4 .", "entity": [{"entity": "GCN4", "entity_type": "GENE", "pos": [26, 30]}, {"entity": "HIS3", "entity_type": "GENE", "pos": [172, 176]}, {"entity": "HIS4", "entity_type": "GENE", "pos": [181, 185]}], "task": "NER"}
{"text": "U . S . A .", "entity": [], "task": "NER"}
{"text": "Human plastin genes .", "entity": [{"entity": "Human plastin genes", "entity_type": "GENE", "pos": [0, 19]}], "task": "NER"}
{"text": "Role of the CCAAT / enhancer binding protein - alpha transcription factor in the glucocorticoid stimulation of p21waf1 / cip1 gene promoter activity in growth - arrested rat hepatoma cells .", "entity": [{"entity": "CCAAT / enhancer binding protein - alpha transcription factor", "entity_type": "GENE", "pos": [12, 73]}, {"entity": "p21waf1", "entity_type": "GENE", "pos": [111, 118]}, {"entity": "cip1", "entity_type": "GENE", "pos": [121, 125]}], "task": "NER"}
{"text": "We also demonstrate that a p110RB1 mutant , which is refractory to cell cycle phosphorylation but intact in E1a / large T antigen - binding properties , represses EIIaE with 50 - to 80 - fold greater efficiency than wild - type p110RB1 .", "entity": [{"entity": "p110RB1 mutant", "entity_type": "GENE", "pos": [27, 41]}, {"entity": "E1a", "entity_type": "GENE", "pos": [108, 111]}, {"entity": "large T antigen", "entity_type": "GENE", "pos": [114, 129]}, {"entity": "EIIaE", "entity_type": "GENE", "pos": [163, 168]}, {"entity": "wild - type p110RB1", "entity_type": "GENE", "pos": [216, 235]}], "task": "NER"}
{"text": "For the target stimuli , P3 amplitude and latency were negatively correlated and most tightly coupled over the frontal - central and right medial / lateral recording sites .", "entity": [], "task": "NER"}
{"text": "We have characterized a new cDNA , 33k - 6 , potentially encoding a tobacco 33 kDa chloroplast RNP ( cp33 ) homologue .", "entity": [{"entity": "tobacco 33 kDa chloroplast RNP ( cp33 ) homologue", "entity_type": "GENE", "pos": [68, 117]}], "task": "NER"}
{"text": "Though it has been established that skinfold anthropometry has severe limitations as a method of deriving total body fat ( TBF ) , the possibility that the problem might be related more to the assumptions implicit in densitometry has to be addressed .", "entity": [], "task": "NER"}
{"text": "Gene GPR 51 was localized by radiation hybrid mapping to chromosome 9 , 4 . 81 cR from the WI - 8684 marker , and proximal to the hereditary sensory neuropathy type 1 locus .", "entity": [{"entity": "Gene GPR 51", "entity_type": "GENE", "pos": [0, 11]}, {"entity": "hereditary sensory neuropathy type 1 locus", "entity_type": "GENE", "pos": [130, 172]}], "task": "NER"}
{"text": "A ) During O2 - ischemia both extracellular [ K + ] and change of pH in the subepicardium are significantly less than in the midmyocardium .", "entity": [], "task": "NER"}
{"text": "Some of these physiological responses are regulated via activation of transcription factors such as activator protein 1 ( AP - 1 ) .", "entity": [{"entity": "activator protein 1", "entity_type": "GENE", "pos": [100, 119]}, {"entity": "AP - 1", "entity_type": "GENE", "pos": [122, 128]}], "task": "NER"}
{"text": "The 1 . 6 - kb cDNA ( CBF - A ) encoding 285 amino acids ( aa ) was obtained , and a beta - galactosidase fusion protein , bacterially produced from the cDNA , bound to DNA fragments containing several CArG boxes .", "entity": [{"entity": "CBF - A", "entity_type": "GENE", "pos": [22, 29]}, {"entity": "beta - galactosidase fusion protein", "entity_type": "GENE", "pos": [85, 120]}], "task": "NER"}
{"text": "Alveoli - capillary diffusion .", "entity": [], "task": "NER"}
{"text": "The pattern of expression of this and other Chi26 / Chi33 chimeric promoters suggest that the E - region contains cis - acting sequences which activate transcription in aleurone and silence transcription in leaves .", "entity": [{"entity": "Chi26", "entity_type": "GENE", "pos": [44, 49]}, {"entity": "Chi33", "entity_type": "GENE", "pos": [52, 57]}, {"entity": "E - region", "entity_type": "GENE", "pos": [94, 104]}], "task": "NER"}
{"text": "Interobserver agreement of the Nottingham histologic grading scheme for infiltrating duct carcinoma breast .", "entity": [], "task": "NER"}
{"text": "We have demonstrated that the specific determination and identification of plasma FbDP alone is not sufficient to follow the effectiveness of thrombolytic therapy .", "entity": [{"entity": "FbDP", "entity_type": "GENE", "pos": [82, 86]}], "task": "NER"}
{"text": "To determine the role of the transmembrane region of HN on fusion - promoting activity , mutant HN proteins were expressed and their biological activities examined .", "entity": [{"entity": "HN", "entity_type": "GENE", "pos": [53, 55]}, {"entity": "mutant HN proteins", "entity_type": "GENE", "pos": [89, 107]}], "task": "NER"}
{"text": "Thus , transgene expression directed by both the human and mouse Rb promoters is restricted to a subset of tissues in which Rb is normally expressed during embryogenesis .", "entity": [{"entity": "mouse Rb promoters", "entity_type": "GENE", "pos": [59, 77]}, {"entity": "Rb", "entity_type": "GENE", "pos": [124, 126]}], "task": "NER"}
{"text": "The cDNA is predicted to encode a polypeptide of 298 amino acids that is homologous to the Y - box ( inverted CCAAT ) family of DNA - binding transcription factors .", "entity": [{"entity": "Y - box ( inverted CCAAT ) family of DNA - binding transcription factors", "entity_type": "GENE", "pos": [91, 163]}], "task": "NER"}
{"text": "RAP has been shown to be a useful vaccine target site , and RIP and inhibitory AIPs as therapeutic molecules to prevent and suppress S . aureus infections .", "entity": [{"entity": "RAP", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "RIP", "entity_type": "GENE", "pos": [60, 63]}, {"entity": "AIPs", "entity_type": "GENE", "pos": [79, 83]}], "task": "NER"}
{"text": "First , mutations in the IFNgamma - activated sequence ( GAS ) , either multimerized or in the context of the 1 . 7 - kb IRF - 1 promoter , failed to mediate a PRL response , showing that the IRF - 1 GAS is a target of PRL signaling .", "entity": [{"entity": "IFNgamma - activated sequence", "entity_type": "GENE", "pos": [25, 54]}, {"entity": "GAS", "entity_type": "GENE", "pos": [57, 60]}, {"entity": "1 . 7 - kb IRF - 1 promoter", "entity_type": "GENE", "pos": [110, 137]}, {"entity": "PRL", "entity_type": "GENE", "pos": [160, 163]}, {"entity": "IRF - 1", "entity_type": "GENE", "pos": [192, 199]}, {"entity": "GAS", "entity_type": "GENE", "pos": [200, 203]}, {"entity": "PRL", "entity_type": "GENE", "pos": [219, 222]}], "task": "NER"}
{"text": "However , both RAR - and RXR - specific ligands increase CaSki number by > or = 20 % .", "entity": [{"entity": "RAR", "entity_type": "GENE", "pos": [15, 18]}, {"entity": "RXR", "entity_type": "GENE", "pos": [25, 28]}], "task": "NER"}
{"text": "Tight - binding band structure calculations for beta - MNX ( M = Zr , X = Cl , Br ; M = Hf , X = Cl ) , ZrCl , and Y ( 2 ) C ( 2 ) Br ( 2 ) are reported .", "entity": [], "task": "NER"}
{"text": "The same high degree of sequence homology between the two F . diplosiphon PC alpha and PC beta sequences ( 85 and 77 % , respectively ) was found at both the nucleotide and amino acid levels , and similar results were obtained for interspecies comparisons .", "entity": [{"entity": "PC alpha", "entity_type": "GENE", "pos": [74, 82]}, {"entity": "PC beta sequences", "entity_type": "GENE", "pos": [87, 104]}], "task": "NER"}
{"text": "Interestingly , the expression of Id4 in Sertoli cells is only detectable after stimulation with FSH or cAMP .", "entity": [{"entity": "Id4", "entity_type": "GENE", "pos": [34, 37]}, {"entity": "FSH", "entity_type": "GENE", "pos": [97, 100]}], "task": "NER"}
{"text": "On the basis of the physical interactions between Sxl and Snf , we present a model for Sxl splicing regulation .", "entity": [{"entity": "Sxl", "entity_type": "GENE", "pos": [50, 53]}, {"entity": "Snf", "entity_type": "GENE", "pos": [58, 61]}, {"entity": "Sxl", "entity_type": "GENE", "pos": [87, 90]}], "task": "NER"}
{"text": "It thus seems likely that genistein affects a common pathway downstream of these signals .", "entity": [], "task": "NER"}
{"text": "LiF thermoluminescence dosimeters ( TLD ) in chip form were placed onto 1 eyelid , the skin over the thyroid , and the patient ' s clothes covering the region of breasts and ovaries of female patients and the testicles of male patients .", "entity": [], "task": "NER"}
{"text": "Several positive clones were isolated , one of which encoded the C - terminal 253 amino acids of a putative RNA helicase , a DEAD box protein designated DDX3 .", "entity": [{"entity": "RNA helicase", "entity_type": "GENE", "pos": [108, 120]}, {"entity": "DEAD box protein", "entity_type": "GENE", "pos": [125, 141]}, {"entity": "DDX3", "entity_type": "GENE", "pos": [153, 157]}], "task": "NER"}
{"text": "The related tumor suppressor , p130 , also effects this function . p107 levels increase substantially as cells progress through S phase . p107 induction of E2F DNA binding was observed primarily in S phase cells coincident with the increase in p107 protein levels .", "entity": [{"entity": "p130", "entity_type": "GENE", "pos": [31, 35]}, {"entity": "p107", "entity_type": "GENE", "pos": [67, 71]}, {"entity": "p107", "entity_type": "GENE", "pos": [138, 142]}, {"entity": "E2F", "entity_type": "GENE", "pos": [156, 159]}, {"entity": "p107 protein", "entity_type": "GENE", "pos": [244, 256]}], "task": "NER"}
{"text": "We conclude from these observations that the cTnC 3 ' Ile element is a composite enhancer that functions through the combined interactions of at least five regulatory elements and their cognate binding factors : three or four E - boxes , a MEF - 2 site , and a MEF - 3 site .", "entity": [{"entity": "cTnC 3 ' Ile element", "entity_type": "GENE", "pos": [45, 65]}, {"entity": "MEF - 2 site", "entity_type": "GENE", "pos": [240, 252]}, {"entity": "MEF - 3 site", "entity_type": "GENE", "pos": [261, 273]}], "task": "NER"}
{"text": "These data suggest that the secreted , truncated receptor encoded by the 2 . 6 - kb c - erbB transcript can bind to TGF alpha and may play an important growth - regulatory function in vitro .", "entity": [{"entity": "2 . 6 - kb c - erbB transcript", "entity_type": "GENE", "pos": [73, 103]}, {"entity": "TGF alpha", "entity_type": "GENE", "pos": [116, 125]}], "task": "NER"}
{"text": "In this paper we review evidence on smoking and lung cancer among Latinos , including findings from several unpublished studies and technical reports .", "entity": [], "task": "NER"}
{"text": "Although several large waterborne outbreaks occurred during the past decade , most were in small communities .", "entity": [], "task": "NER"}
{"text": "Many of the metabolic effects induced by thiazide diuretics , however , can be limited by the use of low doses .", "entity": [], "task": "NER"}
{"text": "Uptake of colicins required different domains in TonB , for colicin B and M around residue 160 and for colicin Ia , a domain closer to the C - terminal end .", "entity": [{"entity": "colicins", "entity_type": "GENE", "pos": [10, 18]}, {"entity": "TonB", "entity_type": "GENE", "pos": [49, 53]}, {"entity": "colicin B and M", "entity_type": "GENE", "pos": [60, 75]}, {"entity": "colicin Ia", "entity_type": "GENE", "pos": [103, 113]}], "task": "NER"}
{"text": "A phase II study of interferon - alpha , interleukin - 2 and 5 - fluorouracil in advanced renal carcinoma : clinical data and laboratory evidence of protease activation .", "entity": [{"entity": "interferon - alpha", "entity_type": "GENE", "pos": [20, 38]}, {"entity": "interleukin - 2", "entity_type": "GENE", "pos": [41, 56]}], "task": "NER"}
{"text": "Three putative ORFs have significant homology with known proteins : L0968 is a new member of the very large ' seripauperins ' family , comprising at least 20 yeast members ; L1313 is a new ABC transporter highly homologous to the yeast cadmium resistance protein Ycf1p and to the human multidrug resistance protein hMRP1 ; the C - terminal part of L1325 present in our sequence is very homologous to the fruit fly abdominal segment formation protein Pumilio .", "entity": [{"entity": "L0968", "entity_type": "GENE", "pos": [68, 73]}, {"entity": "' seripauperins '", "entity_type": "GENE", "pos": [108, 125]}, {"entity": "L1313", "entity_type": "GENE", "pos": [174, 179]}, {"entity": "ABC transporter", "entity_type": "GENE", "pos": [189, 204]}, {"entity": "Ycf1p", "entity_type": "GENE", "pos": [263, 268]}, {"entity": "human multidrug resistance protein", "entity_type": "GENE", "pos": [280, 314]}, {"entity": "hMRP1", "entity_type": "GENE", "pos": [315, 320]}, {"entity": "L1325", "entity_type": "GENE", "pos": [348, 353]}, {"entity": "Pumilio", "entity_type": "GENE", "pos": [450, 457]}], "task": "NER"}
{"text": "Previously , we reported the identification of a 23 - kD protein that interacts with zyxin in vitro ( Sadler et al . , 1992 ) .", "entity": [{"entity": "zyxin", "entity_type": "GENE", "pos": [85, 90]}], "task": "NER"}
{"text": "Most significantly , the cyclin E - Cdk2 complex is maximally active at the G1 / S transition , and overexpression of cyclin E decreases the time it takes the cell to complete G1 and enter S phase .", "entity": [{"entity": "cyclin E", "entity_type": "GENE", "pos": [25, 33]}, {"entity": "Cdk2", "entity_type": "GENE", "pos": [36, 40]}, {"entity": "cyclin E", "entity_type": "GENE", "pos": [118, 126]}], "task": "NER"}
{"text": "In this report , we demonstrate that FRS2 forms a complex with the N - terminal SH2 domain of the protein tyrosine phosphatase Shp2 in response to FGF stimulation .", "entity": [{"entity": "FRS2", "entity_type": "GENE", "pos": [37, 41]}, {"entity": "N - terminal SH2 domain", "entity_type": "GENE", "pos": [67, 90]}, {"entity": "protein tyrosine phosphatase Shp2", "entity_type": "GENE", "pos": [98, 131]}, {"entity": "FGF", "entity_type": "GENE", "pos": [147, 150]}], "task": "NER"}
{"text": "In static conditions , body sway was assessed using a conventional force platform with eyes open and with eyes closed .", "entity": [], "task": "NER"}
{"text": "Antiserum raised against rat liver S6 kinase specifically immunoprecipitates the purified 32P - labeled H4 hepatoma insulin - stimulated S6 kinase .", "entity": [{"entity": "rat liver S6 kinase", "entity_type": "GENE", "pos": [25, 44]}, {"entity": "S6 kinase", "entity_type": "GENE", "pos": [137, 146]}], "task": "NER"}
{"text": "In vitro , SHIP catalyzes the conversion of the phosphoinositide 3 - kinase ( PI3K ) product phosphatidylinositol 3 , 4 , 5 - trisphosphate ( PIP3 ) into phosphatidylinositol 3 , 4 - bisphosphate .", "entity": [{"entity": "SHIP", "entity_type": "GENE", "pos": [11, 15]}, {"entity": "phosphoinositide 3 - kinase", "entity_type": "GENE", "pos": [48, 75]}, {"entity": "PI3K", "entity_type": "GENE", "pos": [78, 82]}], "task": "NER"}
{"text": "A species comparison of cDNA sequences and isolation of a genomic clone .", "entity": [], "task": "NER"}
{"text": "The study of the intensity of pain evoked by heat is relatively exhaustive : the influence of various local , stimulus - dependent or general factors upon threshold values has been well studied , as has the relation between pain and stimulus intensities .", "entity": [], "task": "NER"}
{"text": "However , they had no cross - resistance to quinolone , josamycin and tylosin .", "entity": [], "task": "NER"}
{"text": "A search was conducted for suppressors of the inositol auxotrophic phenotype of the ino4 - 8 mutant of yeast .", "entity": [{"entity": "ino4 - 8 mutant", "entity_type": "GENE", "pos": [84, 99]}], "task": "NER"}
{"text": "Diabetic osteopathy .", "entity": [], "task": "NER"}
{"text": "A simple technique for obtaining ultra - thin sections of coccidian oocysts is reported .", "entity": [], "task": "NER"}
{"text": "These data , taken together , suggest that CRF produces its behavioral activating and anxiogenic effects , at least in part , by increasing the activity of LC noradrenergic neurons .", "entity": [{"entity": "CRF", "entity_type": "GENE", "pos": [43, 46]}], "task": "NER"}
{"text": "Moyamoya is an intriguing and controversial syndrome .", "entity": [], "task": "NER"}
{"text": "An ethnic analysis was made of 8947 cases of primary central nervous system ( CNS ) tumors seen at the Armed Forces Institute of Pathology ( AFIP ) , Washington , DC , from 1971 to 1985 .", "entity": [], "task": "NER"}
{"text": "SN - 38 rebound concentrations were observed in many courses at about 0 . 5 to 1 hour following the end of the i . v . infusion , which is suggestive of enterohepatic recycling .", "entity": [], "task": "NER"}
{"text": "Kondo effect in Cu ( Fe ) films .", "entity": [], "task": "NER"}
{"text": "The S3 protein also contains a DNA repair activity , efficiently processing 8 - oxoguanine residues in DNA via an N - glycosylase / apurinic - apyrimidinic ( AP ) lyase activity .", "entity": [{"entity": "S3 protein", "entity_type": "GENE", "pos": [4, 14]}, {"entity": "N - glycosylase", "entity_type": "GENE", "pos": [114, 129]}, {"entity": "apurinic - apyrimidinic ( AP ) lyase", "entity_type": "GENE", "pos": [132, 168]}], "task": "NER"}
{"text": "The orf2 gene product is a protein of 79 amino acids with characteristics similar to those of the Tat ( transactivator ) proteins of the ungulate lentiviruses .", "entity": [{"entity": "Tat", "entity_type": "GENE", "pos": [98, 101]}, {"entity": "transactivator", "entity_type": "GENE", "pos": [104, 118]}], "task": "NER"}
{"text": "This paper describes a longitudinal study in which clinical parameters and aspartate aminotransferase ( AST ) in gingival crevicular fluid ( GCF ) were monitored bimonthly over a 6 - 12 months period in 970 sites from 7 treated periodontitis patients .", "entity": [{"entity": "aspartate aminotransferase", "entity_type": "GENE", "pos": [75, 101]}, {"entity": "AST", "entity_type": "GENE", "pos": [104, 107]}], "task": "NER"}
{"text": "Our results show that unlike the case for sos1 , sos2 gene function is dispensable for normal mouse development , growth , and fertility .", "entity": [{"entity": "sos1", "entity_type": "GENE", "pos": [42, 46]}, {"entity": "sos2 gene", "entity_type": "GENE", "pos": [49, 58]}], "task": "NER"}
{"text": "This finding is of importance because it completes an explanation for central near - location errors in the partial - report bar - probe task .", "entity": [], "task": "NER"}
{"text": "Patients were treated with either 4 . 8 million units of procaine penicillin with 1 g probenecid , 3 . 5 or 4 . 5 g of ampicillin with 1 g probenecid , or 9 . 5 g of tetracycline given over 4 days .", "entity": [], "task": "NER"}
{"text": "Here , we analyzed the interaction of the Lactococcus lactis Ll . LtrB group II intron endonuclease with its DNA target site by DNA footprinting and modification - interference approaches .", "entity": [{"entity": "Lactococcus lactis Ll . LtrB group II intron endonuclease", "entity_type": "GENE", "pos": [42, 99]}], "task": "NER"}
{"text": "Treatment of JEA2 cells with interleukin ( IL ) - 7 induces CBLB phosphorylation as well .", "entity": [{"entity": "interleukin ( IL ) - 7", "entity_type": "GENE", "pos": [29, 51]}, {"entity": "CBLB", "entity_type": "GENE", "pos": [60, 64]}], "task": "NER"}
{"text": "Plasmid pNK21 , in which 2 . 05 - kb sequence covering the region encoding the nitrilase was was placed under the control of the lac promoter , directed overproduction of enzymatically active nitrilase in response to addition of isopropyl beta - D - thiogalactopyranoside in Escherichia coli .", "entity": [{"entity": "nitrilase", "entity_type": "GENE", "pos": [79, 88]}, {"entity": "lac promoter", "entity_type": "GENE", "pos": [129, 141]}, {"entity": "enzymatically active nitrilase", "entity_type": "GENE", "pos": [171, 201]}], "task": "NER"}
{"text": "Penicillamine - induced myasthenia gravis associated with antibodies to acetylcholine receptor .", "entity": [{"entity": "acetylcholine receptor", "entity_type": "GENE", "pos": [72, 94]}], "task": "NER"}
{"text": "UV cross - linking and Southwestern analysis suggested that KTP1 is a DNA - binding protein clearly distinct from AP2 , and this protein may be responsible for the basal keratinocyte - specific expression of the BPAG1 gene .", "entity": [{"entity": "KTP1", "entity_type": "GENE", "pos": [60, 64]}, {"entity": "AP2", "entity_type": "GENE", "pos": [114, 117]}, {"entity": "BPAG1 gene", "entity_type": "GENE", "pos": [212, 222]}], "task": "NER"}
{"text": "In frozen sections the spots appear as blue labelled neurones with a light microscope , or as a brilliant red neurones surrounded by reddish tissue with a fluorescence microscope .", "entity": [], "task": "NER"}
{"text": "CONCLUSIONS : Elevation of TBARS and decrease of GSH show the presence of oxidative stress during the PFD treatment with hemodiafilter SG3 .", "entity": [], "task": "NER"}
{"text": "Like the DMA , but unlike all other mammalian class II A genes , the zebrafish gene codes for two cysteine residues which might potentially be involved in the formation of a disulfide bond in the alpha 1 domain .", "entity": [{"entity": "DMA", "entity_type": "GENE", "pos": [9, 12]}, {"entity": "mammalian class II A genes", "entity_type": "GENE", "pos": [36, 62]}], "task": "NER"}
{"text": "For any given age , high - stressed plantaris tendons were of a higher fatigue quality than low - stressed extensor tendons .", "entity": [], "task": "NER"}
{"text": "A mutated ABF1 site that displays a very low affinity for ABF1 does not functionally replace the ILV1 REB1 site .", "entity": [{"entity": "mutated ABF1 site", "entity_type": "GENE", "pos": [2, 19]}, {"entity": "ABF1", "entity_type": "GENE", "pos": [58, 62]}, {"entity": "ILV1", "entity_type": "GENE", "pos": [97, 101]}, {"entity": "REB1 site", "entity_type": "GENE", "pos": [102, 111]}], "task": "NER"}
{"text": "It is of interest that , aside from starvation , the nutrition catastrophes of the past , including scurvy ( vitamin C deficiency ) resulting from lack of fresh vegetables and fruit and beriberi ( vitamin B1 deficiency ) from consumption of polished rice , are forgotten and only of interest as history .", "entity": [], "task": "NER"}
{"text": "In contrast , overexpression of the DREB2A cDNA induced weak expression of the target genes under unstressed conditions and caused growth retardation of the transgenic plants .", "entity": [{"entity": "DREB2A cDNA", "entity_type": "GENE", "pos": [36, 47]}], "task": "NER"}
{"text": "In vitro , c - Src phosphorylated FAK Tyr - 925 in a glutathione S - transferase - FAK C - terminal domain fusion protein , whereas FAK did not .", "entity": [{"entity": "c - Src", "entity_type": "GENE", "pos": [11, 18]}, {"entity": "FAK Tyr - 925", "entity_type": "GENE", "pos": [34, 47]}, {"entity": "glutathione S - transferase", "entity_type": "GENE", "pos": [53, 80]}, {"entity": "FAK", "entity_type": "GENE", "pos": [83, 86]}], "task": "NER"}
{"text": "The aetiology and management of diabetic impotence is well - documented ; the effects of diabetes on female sexuality are not so clear .", "entity": [], "task": "NER"}
{"text": "The percentage distribution of types of fixation disparity curves was found to be similar to some previous studies , with a higher prevalence of Type I curve ( 64 . 3 % ) , followed by Type II ( 28 . 6 % ) and Type III ( 7 . 1 % ) curves .", "entity": [], "task": "NER"}
{"text": "1 . 23 ) as a PPARalpha - interacting protein .", "entity": [{"entity": "PPARalpha - interacting protein", "entity_type": "GENE", "pos": [14, 45]}], "task": "NER"}
{"text": "Reading disability in twins .", "entity": [], "task": "NER"}
{"text": "Analysis of the 5 ' and 3 ' termini of the transcripts produced in vivo from the puf operon of R . sphaeroides PUF delta 348 - 420 ( three transcripts ; 0 . 59 , 0 . 64 , and 2 . 63 kilobases ) lacking the puf - intercistronic terminator structure were identical to those of the corresponding puf transcripts derived from wild - type R . sphaeroides 2 . 4 . 1 ( four transcripts ; 0 . 50 , 0 . 66 , 0 . 71 , and 2 . 7 kilobases ) showing that the transcripts begin and end at the same sites .", "entity": [{"entity": "puf operon of R . sphaeroides", "entity_type": "GENE", "pos": [81, 110]}, {"entity": "PUF delta 348 - 420", "entity_type": "GENE", "pos": [111, 130]}, {"entity": "puf transcripts", "entity_type": "GENE", "pos": [293, 308]}], "task": "NER"}
{"text": "The mean amount of blood loss prior to time of injection was 4 . 5 units ( a range of 3 to 10 units ) .", "entity": [], "task": "NER"}
{"text": "Several of the drugs used in the management of MAC have been associated with significant drug interactions involving the cytochrome P450 ( CYP ) enzyme system .", "entity": [{"entity": "cytochrome P450", "entity_type": "GENE", "pos": [121, 136]}, {"entity": "CYP", "entity_type": "GENE", "pos": [139, 142]}], "task": "NER"}
{"text": "Therapy and prevention of irreversible shock with pharmacological doses of some corticosteroids", "entity": [], "task": "NER"}
{"text": "Suppression of the cka1 delta cka2 - 8 mutant phenotype occurs by interaction of CKB1 with the defective , cka2 - 8 - encoded , catalytic subunit .", "entity": [{"entity": "cka1 delta cka2 - 8 mutant", "entity_type": "GENE", "pos": [19, 45]}, {"entity": "CKB1", "entity_type": "GENE", "pos": [81, 85]}, {"entity": "cka2 - 8", "entity_type": "GENE", "pos": [107, 115]}], "task": "NER"}
{"text": "Historically , Cyps were first identified by their ability to bind the immunosuppressive agent cyclosporin A ( CsA ) with high affinity ; they later were found to have peptidyl - prolyl cis - trans isomerase ( PPIase ) activity , which catalyzes the folding of oligopeptides at proline - peptide bonds in vitro and may be important for protein folding in vivo .", "entity": [{"entity": "Cyps", "entity_type": "GENE", "pos": [15, 19]}, {"entity": "peptidyl - prolyl cis - trans isomerase", "entity_type": "GENE", "pos": [168, 207]}, {"entity": "PPIase", "entity_type": "GENE", "pos": [210, 216]}], "task": "NER"}
{"text": "Reduced glutathione in whole blood decreases within a blood Se range of 1 . 01 to 2 . 28 micrograms in the high Se area .", "entity": [], "task": "NER"}
{"text": "Promoter elements and transcriptional control of the mouse acetylcholinesterase gene .", "entity": [{"entity": "mouse acetylcholinesterase gene", "entity_type": "GENE", "pos": [53, 84]}], "task": "NER"}
{"text": "To our knowledge 108 cases of EAT treated by catheter ablation of the ectopic focus are reported in the literature with a success rate superior to 90 % .", "entity": [], "task": "NER"}
{"text": "The authors report two cases of orbital cavernous hemangioma diagnosed by Tc - 99m RBC SPECT .", "entity": [], "task": "NER"}
{"text": "250 , 302 - 311 ] .", "entity": [], "task": "NER"}
{"text": "Arterial compliance measurements using intraarterial pulse contour analysis and a modified Windkessel model were carried out in 19 patients with isolated systolic hypertension ( > or = 160 / < or = 90 mm Hg ) and compared to measurements in 29 patients with essential hypertension ( diastolic blood pressure [ BP ] > or = 95 mm Hg ) and 47 normotensive control subjects .", "entity": [], "task": "NER"}
{"text": "The relationship between CSF somatostatin and peripheral thyroid hormones was assessed in 11 affectively ill patients before and during carbamazepine treatment .", "entity": [{"entity": "CSF somatostatin", "entity_type": "GENE", "pos": [25, 41]}], "task": "NER"}
{"text": "Based on the requirement for CREM / ICER and Rad6B proteins in spermatogenesis , we determined expression of Cdc34 , Rad6B , CREM / ICER isoforms , and the Skp1 - Cullin - F - box ubiquitin protein ligase subunits Cul - 1 and Cul - 2 , which are associated with Cdc34 activity during murine testicular development .", "entity": [{"entity": "CREM", "entity_type": "GENE", "pos": [29, 33]}, {"entity": "ICER", "entity_type": "GENE", "pos": [36, 40]}, {"entity": "Rad6B proteins", "entity_type": "GENE", "pos": [45, 59]}, {"entity": "Cdc34", "entity_type": "GENE", "pos": [109, 114]}, {"entity": "Rad6B", "entity_type": "GENE", "pos": [117, 122]}, {"entity": "CREM", "entity_type": "GENE", "pos": [125, 129]}, {"entity": "ICER", "entity_type": "GENE", "pos": [132, 136]}, {"entity": "Skp1", "entity_type": "GENE", "pos": [156, 160]}, {"entity": "Cullin", "entity_type": "GENE", "pos": [163, 169]}, {"entity": "ubiquitin", "entity_type": "GENE", "pos": [180, 189]}, {"entity": "Cul - 1", "entity_type": "GENE", "pos": [214, 221]}, {"entity": "Cul - 2", "entity_type": "GENE", "pos": [226, 233]}, {"entity": "Cdc34", "entity_type": "GENE", "pos": [262, 267]}], "task": "NER"}
{"text": "Since the early 1900s , a genetic hypothesis has been suggested .", "entity": [], "task": "NER"}
{"text": "Kettin is a large modular protein associated with thin filaments in the Z - disc region of insect muscles .", "entity": [{"entity": "Kettin", "entity_type": "GENE", "pos": [0, 6]}], "task": "NER"}
{"text": "To probe the inter - relationship between the virion - anchoring function and the oligomerization function , we constructed two serotype 3 ( T3 ) sigma 1 deletion mutants in SV40 expression vectors , one lacking the hydrophobic tail and the hinge , and the other lacking an adjacent region which constituted part of the coiled - coil .", "entity": [{"entity": "sigma 1", "entity_type": "GENE", "pos": [146, 153]}], "task": "NER"}
{"text": "This is the first description of an integron located on a composite transposon .", "entity": [], "task": "NER"}
{"text": "By means of early detection and correction of the possible causes , the goal of increasing therapeutic efficacy can be achieved .", "entity": [], "task": "NER"}
{"text": "METHODS : Single white flash ERG , photopic ERG , scotopic ERG and flicker ERG were recorded in 30 cases of unilateral CRVO .", "entity": [], "task": "NER"}
{"text": "RESULT ( S ) : A prospective study was conducted with 44 cycles for 34 couples with nafarelin acetate ( group 1 ) and 47 cycles for 40 couples with buserelin acetate ( group 2 ) with a long IVF protocol ; 68 cycles for 46 couples with nafarelin acetate ( group 3 ) and 56 cycles for 39 couples with buserelin acetate ( group 4 ) with a short IVF protocol ; 39 cycles for 32 couples with nafarelin acetate ( group 5 ) and 50 cycles for 30 couples with buserelin acetate ( group 6 ) with a long ICSI protocol ; and 87 cycles for 60 couples with nafarelin acetate ( group 7 ) and 81 cycles for 61 couples with buserelin acetate ( group 8 ) with a short ICSI protocol .", "entity": [], "task": "NER"}
{"text": "Mutations in the beta - galactosidase gene result in the lysosomal storage disorders GM1 - gangliosidosis and Morquio B syndrome .", "entity": [{"entity": "beta - galactosidase gene", "entity_type": "GENE", "pos": [17, 42]}], "task": "NER"}
{"text": "Angiographic follow - up was obtained in 92 % of patients with a primary success of angioplasty .", "entity": [], "task": "NER"}
{"text": "However , it is only loosely associated , or not associated , with viral particles . gp170 is generated by an alternatively spliced Env mRNA using a splice donor and splice acceptor pair localized within the env open reading frame ( ORF ) , which is normally used to generate Bell and Bet transcripts derived from the internal promoter within the env ORF . gp170 is expressed at a level 30 to 50 % of the Env precursor gp130 .", "entity": [{"entity": "gp170", "entity_type": "GENE", "pos": [85, 90]}, {"entity": "Env mRNA", "entity_type": "GENE", "pos": [132, 140]}, {"entity": "env open reading frame ( ORF )", "entity_type": "GENE", "pos": [208, 238]}, {"entity": "Bell", "entity_type": "GENE", "pos": [276, 280]}, {"entity": "Bet transcripts", "entity_type": "GENE", "pos": [285, 300]}, {"entity": "env ORF", "entity_type": "GENE", "pos": [347, 354]}, {"entity": "gp170", "entity_type": "GENE", "pos": [357, 362]}, {"entity": "Env precursor", "entity_type": "GENE", "pos": [405, 418]}, {"entity": "gp130", "entity_type": "GENE", "pos": [419, 424]}], "task": "NER"}
{"text": "They are both insensitive to inhibitors of serine and aspartyl proteinases but are sensitive to sulfhydryl reagents and 0 . 5 mM ZnCl2 .", "entity": [{"entity": "serine and aspartyl proteinases", "entity_type": "GENE", "pos": [43, 74]}], "task": "NER"}
{"text": "The Brassica BTH1 gene may correspond to the Arabidopsis TH - 1 gene .", "entity": [{"entity": "Brassica BTH1 gene", "entity_type": "GENE", "pos": [4, 22]}, {"entity": "Arabidopsis TH - 1 gene", "entity_type": "GENE", "pos": [45, 68]}], "task": "NER"}
{"text": "Electron microscopic visualization of the general population of active genes in flies overexpressing hnRNP proteins also indicated that the great majority of genes seemed normal in terms of cotranscriptional RNA processing events , although there were a few abnormalities consistent with rare exon - skipping events .", "entity": [{"entity": "hnRNP proteins", "entity_type": "GENE", "pos": [101, 115]}], "task": "NER"}
{"text": "ESR spectra of Er3 + in SmB6 single crystals : Dynamic Jahn - Teller effect in a mixed - valence compound .", "entity": [], "task": "NER"}
{"text": "T . infestans , T . delpontei , T . rubrovaria , T . sordida , T . guasayana and T . vitticeps from infestans subgroup and T . pallidipennis from rubrofasciata , were studied .", "entity": [], "task": "NER"}
{"text": "When the same single - amino - acid mutations were directly introduced into the parental PV / CBV4 - 2A genome , chimeric viruses with a large - plaque phenotype and a wild - type PV - like growth pattern were obtained upon transfection , an observation demonstrating that these point mutations alone had a drastic effect on the growth of the PV / CBV4 chimeric virus .", "entity": [], "task": "NER"}
{"text": "These results indicate that the 2127 - bp cDNA encodes a functional feline L / B / K - type ALP expressed on cell surfaces via phosphatidylinositol - glycan linkage .", "entity": [{"entity": "L / B / K - type ALP", "entity_type": "GENE", "pos": [75, 95]}], "task": "NER"}
{"text": "Clinical experience gained from a combined study of 252Cf brachytherapy by the staff - members of the Research Institute of Medical Radiology , USSR AMS , was generalized .", "entity": [], "task": "NER"}
{"text": "When the VBP - 1 protein was solely expressed , it located to the cytoplasm and did not localize to the nucleus .", "entity": [{"entity": "VBP - 1 protein", "entity_type": "GENE", "pos": [9, 24]}], "task": "NER"}
{"text": "Inhibition of endogenous Cdk2 by dominant negative Cdk2 attenuated phosphorylation of Thr447 , Thr490 and Thr497 , but had no effect upon Ser581 modification .", "entity": [{"entity": "endogenous Cdk2", "entity_type": "GENE", "pos": [14, 29]}, {"entity": "dominant negative Cdk2", "entity_type": "GENE", "pos": [33, 55]}], "task": "NER"}
{"text": "Treatment of excessive bleeding after cardiopulmonary bypass was based on an algorithm using point - of - care testing with whole blood prothrombin time , activated partial thromboplastin time , heparinase activated clotting time , and platelet count .", "entity": [{"entity": "blood prothrombin", "entity_type": "GENE", "pos": [130, 147]}, {"entity": "thromboplastin", "entity_type": "GENE", "pos": [173, 187]}, {"entity": "heparinase", "entity_type": "GENE", "pos": [195, 205]}], "task": "NER"}
{"text": "Endocarditis remains a life - threatening disease with substantial morbidity and mortality .", "entity": [], "task": "NER"}
{"text": "Association between diaphragm use and asymptomatic bacteriuria .", "entity": [], "task": "NER"}
{"text": "The high prevalence of atrial septal defect in tetralogy of Fallot is cited as a possible analogy because right ventricular pressure is high and right ventricular compliance is low from birth .", "entity": [], "task": "NER"}
{"text": "Experience in a Kenya district hospital", "entity": [], "task": "NER"}
{"text": "Moreover , we studied the relationship between initial percentage of bone marrow plasma cells and prognosis .", "entity": [], "task": "NER"}
{"text": "Analysis of larger cDNA clones demonstrates that there are at least two isoforms of RIP14 that differ in the N - terminal ( A and B ) and hinge ( D ) domains .", "entity": [{"entity": "RIP14", "entity_type": "GENE", "pos": [84, 89]}], "task": "NER"}
{"text": "A genomic clone of the chicken osteopontin - encoding gene ( opn ) was isolated and found to be organized as follows : an untranslated 5 ' exon ; a signal peptide ; a recognition sequence for phosphorylation by casein kinase II ; a domain containing a possible O - linkage site for glycosylation ; a second casein kinase II phosphorylation site ; an exon containing three functional regions , the poly - Asp sequence of seven consecutive Asp residues , the RGD integrin recognition site and a potential N - linkage site for glycosylation ; and a large C - terminal exon which also contains a potential N - linkage site for glycosylation .", "entity": [{"entity": "chicken osteopontin - encoding gene", "entity_type": "GENE", "pos": [23, 58]}, {"entity": "opn", "entity_type": "GENE", "pos": [61, 64]}, {"entity": "casein kinase II", "entity_type": "GENE", "pos": [211, 227]}, {"entity": "casein kinase II phosphorylation site", "entity_type": "GENE", "pos": [307, 344]}, {"entity": "RGD integrin recognition site", "entity_type": "GENE", "pos": [457, 486]}], "task": "NER"}
{"text": "The entire coding region of an ovine endometrial oxytocin receptor ( OTR ) cDNA was generated by PCR , subcloned into the SV40 major late promoter expression vector pSVLJ and transiently expressed in Cos - 7 cells .", "entity": [{"entity": "ovine endometrial oxytocin receptor", "entity_type": "GENE", "pos": [31, 66]}, {"entity": "OTR", "entity_type": "GENE", "pos": [69, 72]}, {"entity": "SV40 major late promoter", "entity_type": "GENE", "pos": [122, 146]}], "task": "NER"}
{"text": "Critical review of tests for the HBs antigen in the detection of infectious blood", "entity": [{"entity": "HBs antigen", "entity_type": "GENE", "pos": [33, 44]}], "task": "NER"}
{"text": "Diff - Quik stain for Tzanck smears .", "entity": [], "task": "NER"}
{"text": "Disease - free interval was greater in node - negative Lx patients for both T1 ( P less than 0 . 007 ) and T2 ( P less than 0 . 05 ) presentations .", "entity": [], "task": "NER"}
{"text": "Deletion analysis defines distinct functional domains for protein - protein and nucleic acid interactions in the ORF1 protein of mouse LINE - 1 .", "entity": [{"entity": "ORF1 protein", "entity_type": "GENE", "pos": [113, 125]}, {"entity": "LINE - 1", "entity_type": "GENE", "pos": [135, 143]}], "task": "NER"}
{"text": "Allergen - stimulated levels of PGD2 were 1274 + / - 565 versus 1468 + / - 679 after prednisone ; likewise , allergen - stimulated 5 - HETE levels were 95 + / - 21 versus 82 + / - 21 ; those of LTE4 were 54 + / - 20 versus 91 + / - 51 ; and those of 15 - HETE were 63 + / - 19 versus 60 + / - 25 .", "entity": [], "task": "NER"}
{"text": "To confirm the data obtained using the HPLC - ESI - MS procedure , fractions of the glycosides from four berries were separated , hydrolyzed , silylated and the sugars were analyzed using gas chromatography - mass spectrometry .", "entity": [], "task": "NER"}
{"text": "Usefulness of computerized tomography in hemodialysis patients .", "entity": [], "task": "NER"}
{"text": "Prevalence of use , claims volume , and expenditures were compared for cisapride , proton pump inhibitors , histamine - 2 receptor antagonists , and the prokinetic agent metoclopramide during these periods .", "entity": [{"entity": "histamine - 2 receptor", "entity_type": "GENE", "pos": [108, 130]}], "task": "NER"}
{"text": "However , the quasiparticle scattering rate tau ( - 1 ) is such that Planck ' s over 2pi / tau approximately 6t ( perpendicular ) , implying that kappa - ( BEDT - TTF ) 2Cu ( NCS ) ( 2 ) meets the criterion used to identify interlayer incoherence .", "entity": [], "task": "NER"}
{"text": "The deduced gene product was found to have significant sequence similarity to the yeast and prokaryotic RNA polymerase subunits involved with subunit assembly .", "entity": [{"entity": "yeast and prokaryotic RNA polymerase subunits", "entity_type": "GENE", "pos": [82, 127]}], "task": "NER"}
{"text": "In two of these nine patients , a decrease in dyskinesia score was observed without a concomitant worsening of parkinsonian symptoms , whereas in the remaining seven , full parkinsonian akinesia followed THDL administration .", "entity": [], "task": "NER"}
{"text": "However , an analogous myristoylated peptide derived from c - Yes also has no inhibitory activity .", "entity": [{"entity": "c - Yes", "entity_type": "GENE", "pos": [58, 65]}], "task": "NER"}
{"text": "The expression of the leukocyte EL - 246 antigen was regulated in the same manner as L - selectin and EL - 246 recognized anti - L - selectin mAb affinity - purified antigen in SDS / PAGE Western blot analysis .", "entity": [{"entity": "leukocyte EL - 246 antigen", "entity_type": "GENE", "pos": [22, 48]}, {"entity": "L - selectin", "entity_type": "GENE", "pos": [85, 97]}, {"entity": "EL - 246", "entity_type": "GENE", "pos": [102, 110]}, {"entity": "anti - L - selectin mAb", "entity_type": "GENE", "pos": [122, 145]}], "task": "NER"}
{"text": "A proposed method .", "entity": [], "task": "NER"}
{"text": "The two SH3 domains are separated by a 54 amino acid linker region , whose length is highly conserved in xenopus , chicken , and mamalian Crk II proteins .", "entity": [{"entity": "SH3 domains", "entity_type": "GENE", "pos": [8, 19]}, {"entity": "mamalian Crk II proteins", "entity_type": "GENE", "pos": [129, 153]}], "task": "NER"}
{"text": "A clinical trial of a new mitomycin C derivative , KW - 2083 ( 7 - N - ( p - hydroxyphenyl ) - mitomycin C )", "entity": [], "task": "NER"}
{"text": "In patients with active TB , cytokines that were elevated in serum were IFN - gamma , IL - 6 and IL - 10 .", "entity": [{"entity": "IFN - gamma", "entity_type": "GENE", "pos": [72, 83]}, {"entity": "IL - 6", "entity_type": "GENE", "pos": [86, 92]}, {"entity": "IL - 10", "entity_type": "GENE", "pos": [97, 104]}], "task": "NER"}
{"text": "Overexpression of p50 in transient cotransfection studies using the proximal CRP promoter ( - 125 / + 9 ) linked to a luciferase reporter caused a 3 - fold increase of luciferase activity , while C / EBPbeta overexpression caused an 18 - fold increase ; simultaneous overexpression of both transcription factors increased luciferase activity approximately 600 - fold .", "entity": [{"entity": "p50", "entity_type": "GENE", "pos": [18, 21]}, {"entity": "CRP promoter", "entity_type": "GENE", "pos": [77, 89]}, {"entity": "luciferase reporter", "entity_type": "GENE", "pos": [118, 137]}, {"entity": "luciferase", "entity_type": "GENE", "pos": [168, 178]}, {"entity": "C / EBPbeta", "entity_type": "GENE", "pos": [196, 207]}, {"entity": "luciferase", "entity_type": "GENE", "pos": [322, 332]}], "task": "NER"}
{"text": "Complexities in the host - pathogen interactions during actual infection with Gram - negative bacteria may account for the difficulties in demonstrating this phenomena in vivo .", "entity": [], "task": "NER"}
{"text": "PKCI - 1 is a member of the HIT family of proteins , shown by sequence identity to be conserved in a broad range of organisms including mycoplasma , plants , and humans .", "entity": [{"entity": "PKCI - 1", "entity_type": "GENE", "pos": [0, 8]}, {"entity": "HIT family", "entity_type": "GENE", "pos": [28, 38]}], "task": "NER"}
{"text": "6 , 320 cells / mm3 , respectively ; P less than . 005 ) ; twelve ( 86 % ) of the 14 inmates who developed AIDS had counts of less than 5 , 000 cells / mm3 , compared with only six ( 14 % ) of the 42 controls ( P less than . 00001 ) .", "entity": [], "task": "NER"}
{"text": "Hpr1 forms , together with Tho2 , Mft1 , and Thp2 , the THO complex , which controls transcription elongation and genome stability in Saccharomyces cerevisiae .", "entity": [{"entity": "Hpr1", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "Tho2", "entity_type": "GENE", "pos": [27, 31]}, {"entity": "Mft1", "entity_type": "GENE", "pos": [34, 38]}, {"entity": "Thp2", "entity_type": "GENE", "pos": [45, 49]}, {"entity": "THO complex", "entity_type": "GENE", "pos": [56, 67]}], "task": "NER"}
{"text": "A new model for objective assessment of cervical ripening : the effect of prostaglandin E2 and prelabor contractility .", "entity": [], "task": "NER"}
{"text": "Insulin - secreting islet - cell tumours of the pancreas .", "entity": [{"entity": "Insulin", "entity_type": "GENE", "pos": [0, 7]}], "task": "NER"}
{"text": "Suprapubic and intravesical methods", "entity": [], "task": "NER"}
{"text": "Previous work established that the TAL1 proteins are phosphorylated exclusively on serine and identified Ser122 as a substrate for the mitogen - activated protein kinase ERK - 1 .", "entity": [{"entity": "TAL1 proteins", "entity_type": "GENE", "pos": [35, 48]}, {"entity": "mitogen - activated protein kinase", "entity_type": "GENE", "pos": [135, 169]}, {"entity": "ERK - 1", "entity_type": "GENE", "pos": [170, 177]}], "task": "NER"}
{"text": "The use of ALAD activity and EP as cumulative lead exposure indicators is suggested .", "entity": [{"entity": "ALAD", "entity_type": "GENE", "pos": [11, 15]}], "task": "NER"}
{"text": "Immunofluorescence obtained using antibodies against alphaI SigmaI / + + betaI SigmaI spectrin and Abl tyrosine kinase but not against alphaII / betaII spectrin colocalized with the overexpressed green fluorescent protein - SH3 - binding protein .", "entity": [{"entity": "alphaI SigmaI / + + betaI SigmaI spectrin", "entity_type": "GENE", "pos": [53, 94]}, {"entity": "Abl tyrosine kinase", "entity_type": "GENE", "pos": [99, 118]}, {"entity": "alphaII / betaII spectrin", "entity_type": "GENE", "pos": [135, 160]}, {"entity": "green fluorescent protein", "entity_type": "GENE", "pos": [196, 221]}, {"entity": "SH3 - binding protein", "entity_type": "GENE", "pos": [224, 245]}], "task": "NER"}
{"text": "CONCLUSIONS : The present study showed it is possible to use a modified Stroop task as a measure of implicit processing of alcohol stimuli .", "entity": [], "task": "NER"}
{"text": "Furthermore , the rapid light - mediated increase of CPRF proteins was insensitive to transcriptional inhibitors , suggesting that a post - transcriptional mechanism controls CPRF accumulation .", "entity": [{"entity": "CPRF proteins", "entity_type": "GENE", "pos": [53, 66]}, {"entity": "CPRF", "entity_type": "GENE", "pos": [175, 179]}], "task": "NER"}
{"text": "43 % , 6 / 14 ; P = 0 . 013 ) , whereas , in RCC samples with VHL methylation or mutation , the frequency of 3p14 - p21 LOH did not differ from that of sp25 - p26 ( 72 % , 18 / 25 vs .", "entity": [{"entity": "VHL", "entity_type": "GENE", "pos": [62, 65]}], "task": "NER"}
{"text": "One patient had chronic dysphoria and one encephalopatia toxica .", "entity": [], "task": "NER"}
{"text": "A single clone , which was conserved and had near - perfect homology to eight human / rodent expressed sequence tags , was used as template for 5 ' and 3 ' rapid amplification of cDNA ends and SPICE ( system for polymerase chain reaction amplification of cDNA ends ) reactions to obtain the 3 . 6 - kb cDNA , LGL2 ( Genbank , AF 110195 ) encoding a deduced polypeptide ( lgl2 ) of 963 amino acids .", "entity": [{"entity": "LGL2", "entity_type": "GENE", "pos": [309, 313]}, {"entity": "Genbank , AF 110195", "entity_type": "GENE", "pos": [316, 335]}, {"entity": "lgl2", "entity_type": "GENE", "pos": [371, 375]}], "task": "NER"}
{"text": "Effect of dimethyl sulfoxide on cooling rates of unrestrained rats .", "entity": [], "task": "NER"}
{"text": "The GIS software program , ArcView , was used for spatial analysis and distance calculations . chi2 Tests were used to compare the distribution of the characteristics between intersection and midblock collisions .", "entity": [], "task": "NER"}
{"text": "We have analyzed the role of the HU protein in invertasome assembly when the enhancer is located at variable positions close to one of the recombination sites .", "entity": [{"entity": "HU protein", "entity_type": "GENE", "pos": [33, 43]}], "task": "NER"}
{"text": "We compared these responses for six hatchling and eight adult Chrysemys picta from an Ohio population .", "entity": [], "task": "NER"}
{"text": "The likelihood of death was more than 3 times higher among patients in the ERA - II group ( mortality risk ratio 3 . 82 [ 95 % CI 1 . 48 % to 9 . 84 ] , p = 0 . 006 ) .", "entity": [], "task": "NER"}
{"text": "Pros and cons of selective inhibition of cyclooxygenase - 2 versus dual lipoxygenase / cyclooxygenase inhibition : is two better than one ?", "entity": [{"entity": "cyclooxygenase - 2", "entity_type": "GENE", "pos": [41, 59]}, {"entity": "lipoxygenase", "entity_type": "GENE", "pos": [72, 84]}, {"entity": "cyclooxygenase", "entity_type": "GENE", "pos": [87, 101]}], "task": "NER"}
{"text": "INTERNET is literally a world of data , dialogue , and discourse on any topic imaginable , right at your fingertips .", "entity": [], "task": "NER"}
{"text": "Here we show that the nucleotide in the middle of the anticodon ( i . e . , psi 35 ) also contributes to the suppressor efficiency displayed by cytoplasmic tRNA ( Tyr ) .", "entity": [{"entity": "cytoplasmic tRNA ( Tyr )", "entity_type": "GENE", "pos": [144, 168]}], "task": "NER"}
{"text": "We established that , in unstimulated lymphocytes , the Src homology 2 ( SH2 ) and SH3 domain - containing protein Grb2 and the p85 subunit of phosphatidylinositol 3 - kinase , associate constitutively with Cbl via their SH3 domains .", "entity": [{"entity": "Src homology 2", "entity_type": "GENE", "pos": [56, 70]}, {"entity": "SH2", "entity_type": "GENE", "pos": [73, 76]}, {"entity": "SH3 domain - containing protein", "entity_type": "GENE", "pos": [83, 114]}, {"entity": "Grb2", "entity_type": "GENE", "pos": [115, 119]}, {"entity": "p85", "entity_type": "GENE", "pos": [128, 131]}, {"entity": "phosphatidylinositol 3 - kinase", "entity_type": "GENE", "pos": [143, 174]}, {"entity": "Cbl", "entity_type": "GENE", "pos": [207, 210]}, {"entity": "SH3 domains", "entity_type": "GENE", "pos": [221, 232]}], "task": "NER"}
{"text": "In addition , Fc epsilon R1 cross - linking activates PI 3 - kinase .", "entity": [{"entity": "Fc epsilon R1", "entity_type": "GENE", "pos": [14, 27]}, {"entity": "PI 3 - kinase", "entity_type": "GENE", "pos": [54, 67]}], "task": "NER"}
{"text": "Similarly , an increase in CAT expression from the same construct ( pBLCAT - ENDOA ) was also observed in 7AQS2 . 1 cells .", "entity": [{"entity": "CAT", "entity_type": "GENE", "pos": [27, 30]}, {"entity": "ENDOA", "entity_type": "GENE", "pos": [77, 82]}], "task": "NER"}
{"text": "Indirect determination of maximal O2 consumption in man .", "entity": [], "task": "NER"}
{"text": "The two complexes were detected with a similar activation kinetics upon IL - 4 stimulation .", "entity": [{"entity": "IL - 4", "entity_type": "GENE", "pos": [72, 78]}], "task": "NER"}
{"text": "Although the occurrence of any ventricular ectopic activity , as detected by either or both methods , was common , the incidence was significantly higher ( P less than 0 . 001 ) in patients with coronary heart disease ( 86 percent ; 77 / 90 ) , as compared to that in normal subjects ( 40 percent ; 12 / 30 ) .", "entity": [], "task": "NER"}
{"text": "The frequency of eating dark - meat fish was positively associated with serum eicosapentaenoic acid and docosahexaenoic acid , omega3 fatty acids , and inversely associated with serum stearic acid and linoleic acid .", "entity": [], "task": "NER"}
{"text": "These 8 - oxoguanine DNA glycosylases , hOgg1 ( human ) and mOgg1 ( murine ) , are homologous to each other and to yeast Ogg1 .", "entity": [{"entity": "8 - oxoguanine DNA glycosylases", "entity_type": "GENE", "pos": [6, 37]}, {"entity": "hOgg1", "entity_type": "GENE", "pos": [40, 45]}, {"entity": "mOgg1", "entity_type": "GENE", "pos": [60, 65]}, {"entity": "yeast Ogg1", "entity_type": "GENE", "pos": [115, 125]}], "task": "NER"}
{"text": "HDE was found to be exclusively targeted to and imported into peroxisomes in both heterologous expression systems .", "entity": [{"entity": "HDE", "entity_type": "GENE", "pos": [0, 3]}], "task": "NER"}
{"text": "Taken together , these results indicate that ICSBP and PU . 1 are critical elements for IL - 18 gene expression .", "entity": [{"entity": "ICSBP", "entity_type": "GENE", "pos": [45, 50]}, {"entity": "PU . 1", "entity_type": "GENE", "pos": [55, 61]}, {"entity": "IL - 18 gene", "entity_type": "GENE", "pos": [88, 100]}], "task": "NER"}
{"text": "Model experiments on pheasants using single doses of the insecticide ( Lindane ) the herbicide ( Terbutryn ) a mineral fertilizer ( calcium ammonium nitrate ) and the fungicide ( HCB ) .", "entity": [], "task": "NER"}
{"text": "The main side - effects were myelosuppression , mucositis and peripheral neuropathy , which were all common and often severe .", "entity": [], "task": "NER"}
{"text": "The decision support system uses the network at its core and helps not only in reaching a diagnosis but also in finding the optimal way to reach that diagnosis .", "entity": [], "task": "NER"}
{"text": "Metapsychiatry is a term born of necessity to designate the important but hitherto unclassified interface between psychiatry and mysticism .", "entity": [], "task": "NER"}
{"text": "Repression was strictly dependent on the presence of upstream Oshox1 binding sites in the reporter gene constructs and a function of the N - terminal region of Oshox1 , preceding the homeodomain .", "entity": [{"entity": "Oshox1", "entity_type": "GENE", "pos": [62, 68]}, {"entity": "Oshox1", "entity_type": "GENE", "pos": [160, 166]}, {"entity": "homeodomain", "entity_type": "GENE", "pos": [183, 194]}], "task": "NER"}
{"text": "Experimental studies and clinical application of plasma ACTH radioimmunoassay kit without extraction process", "entity": [{"entity": "plasma ACTH", "entity_type": "GENE", "pos": [49, 60]}], "task": "NER"}
{"text": "Defects in RT6 expression coincide with increased susceptibility in animal models for insulin - dependent diabetes mellitus and other autoimmune diseases .", "entity": [{"entity": "RT6", "entity_type": "GENE", "pos": [11, 14]}, {"entity": "insulin", "entity_type": "GENE", "pos": [86, 93]}], "task": "NER"}
{"text": "By cloning genes encoding benzene - degradative enzymes , we found that strain JS150 also carries genes for a toluene / benzene - 2 - monooxygenase .", "entity": [{"entity": "toluene / benzene - 2 - monooxygenase", "entity_type": "GENE", "pos": [110, 147]}], "task": "NER"}
{"text": "Thus G17 targets the c - fos promoter CArG sequence via Rho A - dependent pathways , and Rho A appears to play an important role in the regulation of the trophic action of G17 .", "entity": [{"entity": "G17", "entity_type": "GENE", "pos": [5, 8]}, {"entity": "c - fos promoter CArG sequence", "entity_type": "GENE", "pos": [21, 51]}, {"entity": "Rho A", "entity_type": "GENE", "pos": [56, 61]}, {"entity": "Rho A", "entity_type": "GENE", "pos": [89, 94]}, {"entity": "G17", "entity_type": "GENE", "pos": [172, 175]}], "task": "NER"}
{"text": "By contrast with ama - 1 , rpc - 1 was not deleted by mDf4 or larger deficiencies examined , indicating that these genes are no closer than 150 kb .", "entity": [{"entity": "ama - 1", "entity_type": "GENE", "pos": [17, 24]}, {"entity": "rpc - 1", "entity_type": "GENE", "pos": [27, 34]}], "task": "NER"}
{"text": "Expression of the bacteriophage T4 DNA terminase genes 16 and 17 yields multiple proteins .", "entity": [{"entity": "bacteriophage T4 DNA terminase genes 16 and 17", "entity_type": "GENE", "pos": [18, 64]}], "task": "NER"}
{"text": "Rat p8 mRNA was discovered because of its strong activation in pancreas during the acute phase of pancreatitis .", "entity": [{"entity": "Rat p8 mRNA", "entity_type": "GENE", "pos": [0, 11]}], "task": "NER"}
{"text": "Dual signal peptides mediate the signal recognition particle / Sec - independent insertion of a thylakoid membrane polyprotein , PsbY .", "entity": [{"entity": "signal recognition particle", "entity_type": "GENE", "pos": [33, 60]}, {"entity": "Sec", "entity_type": "GENE", "pos": [63, 66]}, {"entity": "PsbY", "entity_type": "GENE", "pos": [129, 133]}], "task": "NER"}
{"text": "Sequence divergence of approximately 16 % reduced transformation frequencies by at least 10 - fold .", "entity": [], "task": "NER"}
{"text": "During subsequent CS - alone trials , the responses of ( + ) MK - 801 - injected mice were extinguished as easily as those of saline - injected mice .", "entity": [], "task": "NER"}
{"text": "The three respective time control groups ( C5 , C10 , and C15 ) were injected with saline solution .", "entity": [], "task": "NER"}
{"text": "Next , to examine the regulation mechanism of CD44 / ERM interaction in vivo , we reexamined the immunoprecipitated CD44 / ERM complex from BHK cells and found that it contains Rho - GDP dissociation inhibitor ( GDI ) , a regulator of Rho GTPase .", "entity": [{"entity": "CD44", "entity_type": "GENE", "pos": [46, 50]}, {"entity": "ERM", "entity_type": "GENE", "pos": [53, 56]}, {"entity": "CD44", "entity_type": "GENE", "pos": [116, 120]}, {"entity": "ERM", "entity_type": "GENE", "pos": [123, 126]}, {"entity": "Rho - GDP dissociation inhibitor", "entity_type": "GENE", "pos": [177, 209]}, {"entity": "GDI", "entity_type": "GENE", "pos": [212, 215]}, {"entity": "Rho GTPase", "entity_type": "GENE", "pos": [235, 245]}], "task": "NER"}
{"text": "Ten patients ( aged 28 - 76 years ) with a terminal jejunostomy located within the first meter of jejunum were treated by infusion of an elemental diet into the distal small bowel ( IEDDSB ) .", "entity": [], "task": "NER"}
{"text": "The illuminator uses a grain - of - wheat light bulb and an adjustable bulb holder fashioned from bent paper clips .", "entity": [], "task": "NER"}
{"text": "The goals of these experiments were to determine whether lactational anestrus would be prolonged by a 48 - h fast at days 13 and 14 postpartum ( pp ) and , if so , to determine whether this effect could be reversed by treatment with the Ob protein leptin .", "entity": [{"entity": "Ob protein", "entity_type": "GENE", "pos": [237, 247]}, {"entity": "leptin", "entity_type": "GENE", "pos": [248, 254]}], "task": "NER"}
{"text": "The kinetics of [ 14C ] NG in the blood of the dosed animals was followed .", "entity": [], "task": "NER"}
{"text": "RESULTS : In patients with necrotising fasciitis the arterial PO2 rose about 7 - fold whereas the arterial PCO2 increased only slightly during exposure to 2 . 5 absolute atmospheres ( ATA ) of oxygen .", "entity": [], "task": "NER"}
{"text": "Coronary arteriographies and ventriculographies corresponding to 274 consecutive patients ( January , 1975 - October , 1978 ) with significant coronary lesions are reviewed .", "entity": [], "task": "NER"}
{"text": "The data show that processing time as a function of intensity is modified not only at the retina but also at later processing sites .", "entity": [], "task": "NER"}
{"text": "Lag phases were 14 . 89 hours + / - 0 . 77 , 13 . 33 hours + / - 0 . 50 , 20 . 22 hours + / - 0 . 76 , and 20 . 00 hours + / - 0 . 79 , respectively , for endothelial cell - induced LDL oxidation .", "entity": [{"entity": "LDL", "entity_type": "GENE", "pos": [182, 185]}], "task": "NER"}
{"text": "Therefore , the Ogg1 protein is a eukaryotic DNA glycosylase / AP lyase .", "entity": [{"entity": "Ogg1 protein", "entity_type": "GENE", "pos": [16, 28]}, {"entity": "DNA glycosylase", "entity_type": "GENE", "pos": [45, 60]}, {"entity": "AP lyase", "entity_type": "GENE", "pos": [63, 71]}], "task": "NER"}
{"text": "Being implicated in insulin and GK gene regulations as a common transcription factor , IPF1 / STF - 1 / PDX - 1 is likely to play an essential role in maintaining normal beta - cell functions .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [20, 27]}, {"entity": "GK gene", "entity_type": "GENE", "pos": [32, 39]}, {"entity": "IPF1", "entity_type": "GENE", "pos": [87, 91]}, {"entity": "STF - 1", "entity_type": "GENE", "pos": [94, 101]}, {"entity": "PDX - 1", "entity_type": "GENE", "pos": [104, 111]}], "task": "NER"}
{"text": "MATERIAL AND METHODS :", "entity": [], "task": "NER"}
{"text": "Salt wars .", "entity": [], "task": "NER"}
{"text": "Finally , synthetic peptides corresponding to the mutant proteins were assessed for the ability to act as substrates for PR .", "entity": [{"entity": "PR", "entity_type": "GENE", "pos": [121, 123]}], "task": "NER"}
{"text": "As an approach to the determination of structure - function relationships in the PRP4 protein , we have isolated more than fifty new alleles of the PRP4 gene through random and site - directed mutagenesis , and have analyzed the phenotypes of many of them .", "entity": [{"entity": "PRP4 protein", "entity_type": "GENE", "pos": [81, 93]}, {"entity": "PRP4 gene", "entity_type": "GENE", "pos": [148, 157]}], "task": "NER"}
{"text": "Brainstem auditory evoked potential responses ( BAEPs ) were recorded from CZ - A1 and CZ - A2 scalp regions in 23 hypertensive and 14 normotensive subjects .", "entity": [], "task": "NER"}
{"text": "Although the Gly252Arg substitution observed in UM : JG5 is non - conservative , it was not possible to distinguish whether it is a mutation or a polymorphism .", "entity": [], "task": "NER"}
{"text": "Two SH2 domains of p120 Ras GTPase - activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase - activating protein . p120 GTPase - activating protein ( GAP ) is a negative regulator of Ras that functions at a key relay point in signal transduction pathways that control cell proliferation .", "entity": [{"entity": "SH2 domains", "entity_type": "GENE", "pos": [4, 15]}, {"entity": "p120", "entity_type": "GENE", "pos": [19, 23]}, {"entity": "Ras", "entity_type": "GENE", "pos": [24, 27]}, {"entity": "GTPase - activating protein", "entity_type": "GENE", "pos": [28, 55]}, {"entity": "p190", "entity_type": "GENE", "pos": [104, 108]}, {"entity": "GTPase - activating protein", "entity_type": "GENE", "pos": [113, 140]}, {"entity": "p120", "entity_type": "GENE", "pos": [143, 147]}, {"entity": "GTPase - activating protein", "entity_type": "GENE", "pos": [148, 175]}, {"entity": "GAP", "entity_type": "GENE", "pos": [178, 181]}, {"entity": "Ras", "entity_type": "GENE", "pos": [211, 214]}], "task": "NER"}
{"text": "Phosphorylation of the ras GTPase - activating protein ( GAP ) by the p93c - fes protein - tyrosine kinase in vitro and formation of GAP - fes complexes via an SH2 domain - dependent mechanism .", "entity": [{"entity": "ras", "entity_type": "GENE", "pos": [23, 26]}, {"entity": "GTPase - activating protein", "entity_type": "GENE", "pos": [27, 54]}, {"entity": "GAP", "entity_type": "GENE", "pos": [57, 60]}, {"entity": "p93c - fes", "entity_type": "GENE", "pos": [70, 80]}, {"entity": "protein - tyrosine kinase", "entity_type": "GENE", "pos": [81, 106]}, {"entity": "GAP", "entity_type": "GENE", "pos": [133, 136]}, {"entity": "fes", "entity_type": "GENE", "pos": [139, 142]}, {"entity": "SH2", "entity_type": "GENE", "pos": [160, 163]}], "task": "NER"}
{"text": "This resulted in a shift of C1 / C2 , so that the effect of collagen was more pronounced ( maximal increase of C1 / C2 = 134 % ) than ADP ( maximal increase of C1 / C2 = 79 % ) .", "entity": [{"entity": "collagen", "entity_type": "GENE", "pos": [60, 68]}], "task": "NER"}
{"text": "A significant increase of gastric mucosal permeability was observed in six normal human subjects after instillation of ethanol ( 20 percent v / v ) .", "entity": [], "task": "NER"}
{"text": "Analysis of domain deletion mutants demonstrated strong synergy between the RRM and a central degenerate RRM repeat in binding to RNA .", "entity": [], "task": "NER"}
{"text": "Overexpression of eIF4E transforms cells , and mutations in eIF4E arrest cells in G , in cdc33 mutants .", "entity": [{"entity": "eIF4E", "entity_type": "GENE", "pos": [18, 23]}, {"entity": "eIF4E", "entity_type": "GENE", "pos": [60, 65]}, {"entity": "cdc33 mutants", "entity_type": "GENE", "pos": [89, 102]}], "task": "NER"}
{"text": "ZF87 specifically binds the ME1a1 element with higher affinity than the ME1a2 element .", "entity": [{"entity": "ZF87", "entity_type": "GENE", "pos": [0, 4]}], "task": "NER"}
{"text": "The unusual properties of TRAC activity and its relationship , if any , with the enigmatic Ku protein , are discussed .", "entity": [{"entity": "TRAC", "entity_type": "GENE", "pos": [26, 30]}, {"entity": "Ku protein", "entity_type": "GENE", "pos": [91, 101]}], "task": "NER"}
{"text": "Structure of the connective stroma of the epididymis in the zebu", "entity": [], "task": "NER"}
{"text": "Characterization of regions of fibronectin besides the arginine - glycine - aspartic acid sequence required for adhesive function of the cell - binding domain using site - directed mutagenesis .", "entity": [{"entity": "fibronectin", "entity_type": "GENE", "pos": [31, 42]}], "task": "NER"}
{"text": "These data suggest that multiple genetic recombination among bacteriophages with different immunities took place to generate the prophage VT1 - Sakai .", "entity": [], "task": "NER"}
{"text": "Transient - expression assay analysis of subclones of pPstI - G localized the trans - active factor to a 3 . 0 - kilobase XbaI fragment .", "entity": [{"entity": "3 . 0 - kilobase XbaI fragment", "entity_type": "GENE", "pos": [105, 135]}], "task": "NER"}
{"text": "We used an immobilized template - based assay to examine transcription termination by VA1 , 7SL , and Alu class III templates and the role of transcript release in the pol III terminator - dependent inhibition of processing of B1 - Alu transcripts .", "entity": [{"entity": "VA1", "entity_type": "GENE", "pos": [86, 89]}, {"entity": "7SL", "entity_type": "GENE", "pos": [92, 95]}, {"entity": "Alu class III", "entity_type": "GENE", "pos": [102, 115]}, {"entity": "pol III", "entity_type": "GENE", "pos": [168, 175]}, {"entity": "B1", "entity_type": "GENE", "pos": [227, 229]}, {"entity": "Alu", "entity_type": "GENE", "pos": [232, 235]}], "task": "NER"}
{"text": "Concentrations of platelet nitrite and total nitrate / nitrite were determined using simple and sensitive nitrate / nitrite fluorometric assay techniques .", "entity": [], "task": "NER"}
{"text": "Using a GTP - dependent , brefeldin A - sensitive in vitro AP - 1 binding assay , we have determined here the parameters of the AP - 1 binding reaction .", "entity": [{"entity": "AP - 1", "entity_type": "GENE", "pos": [59, 65]}, {"entity": "AP - 1", "entity_type": "GENE", "pos": [128, 134]}], "task": "NER"}
{"text": "By using methanol - 0 . 15 M borate buffer of pH 8 . 0 , cate - chol - O - methyltransferase activity might be assayed .", "entity": [{"entity": "cate - chol - O - methyltransferase", "entity_type": "GENE", "pos": [57, 92]}], "task": "NER"}
{"text": "Replacement of Val20 - Leu21 with Ala - Ala produced a dimeric RII beta protein that binds AKAP75 approximately 4 % as avidly as wild - type RII beta .", "entity": [{"entity": "dimeric RII beta protein", "entity_type": "GENE", "pos": [55, 79]}, {"entity": "AKAP75", "entity_type": "GENE", "pos": [91, 97]}, {"entity": "wild - type RII beta", "entity_type": "GENE", "pos": [129, 149]}], "task": "NER"}
{"text": "Plasmodium vivax malaria .", "entity": [], "task": "NER"}
{"text": "Postcontrast images were also acquired in the sagittal ( six patients ) and coronal ( three patients ) planes .", "entity": [], "task": "NER"}
{"text": "Conservation of this zinc finger motif from yeast to mouse and human implies functional importance .", "entity": [], "task": "NER"}
{"text": "In vitro death assays with transient overexpression of deletion constructs of both isoforms using beta - galactosidase as a reporter gene in MCF7 cells suggest the following : 1 ) the nucleotide binding domain may act as a negative regulator of the killing activity of DEFCAP ; 2 ) the LRR / CARD represents a putative constitutively active inducer of apoptosis ; 3 ) the killing activity of LRR / CARD is inhibitable by benzyloxycarbonyl - Val - Ala - Asp ( OMe ) - fluoromethyl ketone and to a lesser extent by Asp - Glu - Val - Asp ( OMe ) - fluoromethyl ketone ; and 4 ) the CARD is critical for killing activity of DEFCAP .", "entity": [{"entity": "beta - galactosidase", "entity_type": "GENE", "pos": [98, 118]}, {"entity": "DEFCAP", "entity_type": "GENE", "pos": [269, 275]}, {"entity": "LRR", "entity_type": "GENE", "pos": [286, 289]}, {"entity": "CARD", "entity_type": "GENE", "pos": [292, 296]}, {"entity": "LRR", "entity_type": "GENE", "pos": [392, 395]}, {"entity": "CARD", "entity_type": "GENE", "pos": [398, 402]}, {"entity": "CARD", "entity_type": "GENE", "pos": [579, 583]}, {"entity": "DEFCAP", "entity_type": "GENE", "pos": [620, 626]}], "task": "NER"}
{"text": "Here , we provide direct evidence that the meiotic defect caused by either unregulated cAPK activity or unregulated ran1 + kinase activity is due to inability to induce transcription of the mei2 + gene , which is required for meiotic initiation .", "entity": [{"entity": "cAPK", "entity_type": "GENE", "pos": [87, 91]}, {"entity": "ran1 + kinase", "entity_type": "GENE", "pos": [116, 129]}, {"entity": "mei2 + gene", "entity_type": "GENE", "pos": [190, 201]}], "task": "NER"}
{"text": "Sailer , K .", "entity": [], "task": "NER"}
{"text": "The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component .", "entity": [], "task": "NER"}
{"text": "The Caenorhabditis elegans NK - 2 class homeoprotein CEH - 22 is involved in combinatorial activation of gene expression in pharyngeal muscle .", "entity": [{"entity": "Caenorhabditis elegans NK - 2 class homeoprotein CEH - 22", "entity_type": "GENE", "pos": [4, 61]}], "task": "NER"}
{"text": "As tat itself dramatically increases HIV - 1 gene expression , it too is presumably regulated in the latent state , and may also be activated by mitogenic stimulation .", "entity": [{"entity": "tat", "entity_type": "GENE", "pos": [3, 6]}], "task": "NER"}
{"text": "The CBS - 1 gene was mapped to human chromosome 10p12 between markers WI - 8535 and WI - 4724 , and is tightly linked to the two STRP markers of D10S1789 and D10S550 .", "entity": [{"entity": "CBS - 1 gene", "entity_type": "GENE", "pos": [4, 16]}, {"entity": "WI - 8535", "entity_type": "GENE", "pos": [70, 79]}, {"entity": "WI - 4724", "entity_type": "GENE", "pos": [84, 93]}, {"entity": "D10S1789", "entity_type": "GENE", "pos": [145, 153]}, {"entity": "D10S550", "entity_type": "GENE", "pos": [158, 165]}], "task": "NER"}
{"text": "We have previously described the partial purification of Ap4A hydrolase from S . pombe [ Robinson , de la Pena and Barnes ( 1993 ) Biochim .", "entity": [{"entity": "Ap4A hydrolase", "entity_type": "GENE", "pos": [57, 71]}], "task": "NER"}
{"text": "Both flavoproteins are active as AhpC reductases and mediate electron transfer , resulting in the NADH - dependent reduction of hydrogen peroxide and cumene hydroperoxide .", "entity": [{"entity": "AhpC reductases", "entity_type": "GENE", "pos": [33, 48]}], "task": "NER"}
{"text": "Together , these results indicate that YTS1 is a bifunctional protein active in both splicing and protein synthesis .", "entity": [{"entity": "YTS1", "entity_type": "GENE", "pos": [39, 43]}], "task": "NER"}
{"text": "The first operon , orf1 - tolQRA , is iron regulated throughout growth , but iron - regulated expression of tolB and oprL fusions occurs only in late log phase .", "entity": [{"entity": "tolQRA", "entity_type": "GENE", "pos": [26, 32]}, {"entity": "tolB", "entity_type": "GENE", "pos": [108, 112]}, {"entity": "oprL fusions", "entity_type": "GENE", "pos": [117, 129]}], "task": "NER"}
{"text": "Thus , STK1 is most likely the human homologue of MO15 .", "entity": [{"entity": "STK1", "entity_type": "GENE", "pos": [7, 11]}, {"entity": "human homologue of MO15", "entity_type": "GENE", "pos": [31, 54]}], "task": "NER"}
{"text": "The human IFI16 gene is a member of an interferon - inducible family of mouse and human genes closely linked on syntenic regions of chromosome 1 .", "entity": [{"entity": "human IFI16 gene", "entity_type": "GENE", "pos": [4, 20]}, {"entity": "interferon", "entity_type": "GENE", "pos": [39, 49]}], "task": "NER"}
{"text": "Late results in the treatment of urotuberculosis", "entity": [], "task": "NER"}
{"text": "Blood samples for determination of fibrinolytic activity and factor VIII in plasma were obtained before and immediately after the end of compression and application of a stocking , respectively .", "entity": [{"entity": "factor VIII", "entity_type": "GENE", "pos": [61, 72]}], "task": "NER"}
{"text": "Exon A1a encodes most of the 5 ' - untranslated region .", "entity": [], "task": "NER"}
{"text": "Methylation interference analysis established at single nucleotide resolution that purified recombinant Fos and Jun proteins bind in a sequence - specific manner to the AP - 1 sites within the VDRE and OC box .", "entity": [{"entity": "Fos", "entity_type": "GENE", "pos": [104, 107]}, {"entity": "Jun proteins", "entity_type": "GENE", "pos": [112, 124]}, {"entity": "AP - 1 sites", "entity_type": "GENE", "pos": [169, 181]}, {"entity": "OC box", "entity_type": "GENE", "pos": [202, 208]}], "task": "NER"}
{"text": "Also , PTx had no effect on shear - dependent activation of JNK .", "entity": [{"entity": "PTx", "entity_type": "GENE", "pos": [7, 10]}, {"entity": "JNK", "entity_type": "GENE", "pos": [60, 63]}], "task": "NER"}
{"text": "Cardiovascular effects in man of intravenous prizidilol hydrochloride ( SK & F 92657 ) ; a new antihypertensive agent .", "entity": [], "task": "NER"}
{"text": "The human p18 gene spans at least 7 . 5 kb and is composed of three exons , two of which encode the p18 protein .", "entity": [{"entity": "human p18 gene", "entity_type": "GENE", "pos": [4, 18]}, {"entity": "p18 protein", "entity_type": "GENE", "pos": [100, 111]}], "task": "NER"}
{"text": "Partial characterization of the CCAAT box in the promoter of the hLGFBP - 1 gene : interaction with negatively acting transcription factors in decidualized human endometrial stromal cells .", "entity": [{"entity": "hLGFBP - 1 gene", "entity_type": "GENE", "pos": [65, 80]}], "task": "NER"}
{"text": "Footprints on the HPV 18 enhancer show five protected regions with homologies to NF1 , AP1 and EFII transcription factor binding motifs .", "entity": [{"entity": "HPV 18 enhancer", "entity_type": "GENE", "pos": [18, 33]}, {"entity": "NF1", "entity_type": "GENE", "pos": [81, 84]}, {"entity": "AP1", "entity_type": "GENE", "pos": [87, 90]}, {"entity": "EFII transcription factor binding motifs", "entity_type": "GENE", "pos": [95, 135]}], "task": "NER"}
{"text": "These cDNAs were found to be derived from the 3 \" - untranslated region ( 3 \" - UTR ) of the methyl - CpG - binding protein 2 gene ( MeCP2 ) .", "entity": [{"entity": "methyl - CpG - binding protein 2 gene", "entity_type": "GENE", "pos": [93, 130]}, {"entity": "MeCP2", "entity_type": "GENE", "pos": [133, 138]}], "task": "NER"}
{"text": "A simple algorithm fitting the data for the moving 192Ir source is proposed .", "entity": [], "task": "NER"}
{"text": "Univariate and multivariate analysis was used to calculate the 5 - year survival probabilities with respect to the following variables : age ( < or = 65 , > 65 ) , sex , depth of invasion ( mucosal , submucosal ) tumor location ( upper , middle and lower third ) , gross appearance ( type I , type II and type III ) , size ( < or = 1 . 5 cm , > 1 . 5 cm ) , presence or absence of lymph node metastasis , histological type ( intestinal , diffuse ) , extent of lymphadenectomy ( limited or extended ) , and type of gastrectomy ( total or distal subtotal ) .", "entity": [], "task": "NER"}
{"text": "Preventing the heterosexual spread of HIV into this vulnerable population is a formidable public health challenge .", "entity": [], "task": "NER"}
{"text": "Carotid body chemoreceptor activity as recorded from the petrosal ganglion in cats .", "entity": [], "task": "NER"}
{"text": "The first decision in management is to consider cardioversion which can be achieved in suitable cases electrically , or pharmacologically with a class Ic antiarrhythmic drug like flecainide or propafenone .", "entity": [], "task": "NER"}
{"text": "Several studies have demonstrated that the corticotropin - releasing factor test ( CRF ) is useful for the aetiological diagnosis of Cushing ' s syndrome : in Cushing ' s disease , as opposed to ectopic ACTH secretion syndrome , the hypothalamus - pituitary - adrenal ( HPA ) axis can still be stimulated by CRF .", "entity": [{"entity": "corticotropin - releasing factor", "entity_type": "GENE", "pos": [43, 75]}, {"entity": "CRF", "entity_type": "GENE", "pos": [83, 86]}, {"entity": "ACTH", "entity_type": "GENE", "pos": [203, 207]}, {"entity": "CRF", "entity_type": "GENE", "pos": [308, 311]}], "task": "NER"}
{"text": "The NF - kappaB / Rel transcription factors participate in the activation of immune system regulatory genes and viral early genes including the human immunodeficiency virus type 1 long terminal repeat .", "entity": [{"entity": "NF - kappaB", "entity_type": "GENE", "pos": [4, 15]}, {"entity": "Rel", "entity_type": "GENE", "pos": [18, 21]}, {"entity": "viral early genes", "entity_type": "GENE", "pos": [112, 129]}, {"entity": "human immunodeficiency virus type 1 long terminal repeat", "entity_type": "GENE", "pos": [144, 200]}], "task": "NER"}
{"text": "These three chromosomes share the transferrin gene ( TF ) , the myosin light polypeptide 3 gene ( MYL3 ) , and the acylpeptide hydrolase gene ( APEH ) .", "entity": [{"entity": "transferrin gene", "entity_type": "GENE", "pos": [34, 50]}, {"entity": "TF", "entity_type": "GENE", "pos": [53, 55]}, {"entity": "myosin light polypeptide 3 gene", "entity_type": "GENE", "pos": [64, 95]}, {"entity": "MYL3", "entity_type": "GENE", "pos": [98, 102]}, {"entity": "acylpeptide hydrolase gene", "entity_type": "GENE", "pos": [115, 141]}, {"entity": "APEH", "entity_type": "GENE", "pos": [144, 148]}], "task": "NER"}
{"text": "The preference for third base codon in Y position prolines is U for the alpha 2 ( VI ) collagen as it is for the human fibrillar collagen genes .", "entity": [{"entity": "alpha 2 ( VI ) collagen", "entity_type": "GENE", "pos": [72, 95]}, {"entity": "human fibrillar collagen genes", "entity_type": "GENE", "pos": [113, 143]}], "task": "NER"}
{"text": "BK - induced translocation and overexpression of PKC isoforms as well as coexpression of inactive or constitutively active mutants of different PKC isozymes provided evidence for a role of the diacylglycerol - sensitive PKCs alpha and epsilon in BK signaling toward MAPK .", "entity": [{"entity": "BK", "entity_type": "GENE", "pos": [0, 2]}, {"entity": "PKC isoforms", "entity_type": "GENE", "pos": [49, 61]}, {"entity": "PKC isozymes", "entity_type": "GENE", "pos": [144, 156]}, {"entity": "PKCs alpha and epsilon", "entity_type": "GENE", "pos": [220, 242]}, {"entity": "BK", "entity_type": "GENE", "pos": [246, 248]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [266, 270]}], "task": "NER"}
{"text": "The rate of decrease of PRA after REM onset closely approximates the most recent estimations of PRA half - life , which suggests that REM onset is associated with a virtual cessation in renin production .", "entity": [{"entity": "renin", "entity_type": "GENE", "pos": [186, 191]}], "task": "NER"}
{"text": "The second ( control ) group was represented by cases diagnosed as HSIL by cytology .", "entity": [], "task": "NER"}
{"text": "Clinical trial endpoints based on magnitude of reduction in HIV - 1 RNA levels provide an important complement to endpoints based on percentage of patients achieving complete virologic suppression .", "entity": [], "task": "NER"}
{"text": "The psi zeta gene has a nonsense mutation in exon 1 but has identical promoter sequence and RNA processing sites to the zeta gene , raising the possibility that both psi zeta and zeta are transcriptionally active .", "entity": [{"entity": "psi zeta gene", "entity_type": "GENE", "pos": [4, 17]}, {"entity": "zeta gene", "entity_type": "GENE", "pos": [120, 129]}, {"entity": "psi zeta", "entity_type": "GENE", "pos": [166, 174]}, {"entity": "zeta", "entity_type": "GENE", "pos": [179, 183]}], "task": "NER"}
{"text": "The expression of cor14b was strongly impaired in the barley albino mutant an , suggesting the involvement of a plastidial factor in the control of gene expression .", "entity": [{"entity": "cor14b", "entity_type": "GENE", "pos": [18, 24]}], "task": "NER"}
{"text": "Pulse monitors in outpatient dental anaesthesia .", "entity": [], "task": "NER"}
{"text": "Synthesis of 2 - ( 2 ' - thiazolyl ) alkanebenzimidazoles - - potential anthelmintics", "entity": [], "task": "NER"}
{"text": "Wild type MEKK1 enhances promoter activity and the activity can be inhibited by dominant negative MEKK1 , MEK1 , MEK7 , MEK3 , p38 / RK , and c - Jun .", "entity": [{"entity": "MEKK1", "entity_type": "GENE", "pos": [10, 15]}, {"entity": "MEKK1", "entity_type": "GENE", "pos": [98, 103]}, {"entity": "MEK1", "entity_type": "GENE", "pos": [106, 110]}, {"entity": "MEK7", "entity_type": "GENE", "pos": [113, 117]}, {"entity": "MEK3", "entity_type": "GENE", "pos": [120, 124]}, {"entity": "p38", "entity_type": "GENE", "pos": [127, 130]}, {"entity": "RK", "entity_type": "GENE", "pos": [133, 135]}, {"entity": "c - Jun", "entity_type": "GENE", "pos": [142, 149]}], "task": "NER"}
{"text": "Tax and the active Tax mutants were able to abrogate the G1 arrest and apoptosis induced by p53 , and this effect does not correlate with an altered localization of nuclear p53 or with the disruption of p53 - DNA complexes .", "entity": [{"entity": "Tax", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "Tax mutants", "entity_type": "GENE", "pos": [19, 30]}, {"entity": "p53", "entity_type": "GENE", "pos": [92, 95]}, {"entity": "nuclear p53", "entity_type": "GENE", "pos": [165, 176]}, {"entity": "p53 - DNA complexes", "entity_type": "GENE", "pos": [203, 222]}], "task": "NER"}
{"text": "Chronic , recurrent multifocal osteomyelitis .", "entity": [], "task": "NER"}
{"text": "Our current study aims at clarifying the role of myristoylation in caveolar targeting using well - characterized acylation mutants of two model proteins , namely Gi1 alpha and c - Src .", "entity": [{"entity": "Gi1 alpha", "entity_type": "GENE", "pos": [162, 171]}, {"entity": "c - Src", "entity_type": "GENE", "pos": [176, 183]}], "task": "NER"}
{"text": "Single substitutions of three highly conserved phenylalanine residues ( Phe - 15 , Phe - 17 , Phe - 27 ) by alanine and substitution of one histidine ( His - 29 ) by glutamine , all located within the putative RNA - binding sites RNP - 1 and RNP - 2 , abolished the nucleic acid - binding activity of CspB .", "entity": [{"entity": "RNP - 1", "entity_type": "GENE", "pos": [230, 237]}, {"entity": "RNP - 2", "entity_type": "GENE", "pos": [242, 249]}, {"entity": "CspB", "entity_type": "GENE", "pos": [301, 305]}], "task": "NER"}
{"text": "The lack of heterozygous positions essentially facilitates on the one hand the data analysis and on the other hand the detection of new alleles .", "entity": [], "task": "NER"}
{"text": "BACKGROUND : The extract of medicinal plants containing curcumin is traditionally believed to have a positive contraction effect on the human gall - bladder .", "entity": [], "task": "NER"}
{"text": "Moreover , the formation of the complex between IclR and the operator / promoter region has been found to be impaired by phosphoenol pyruvate but insensitive to acetate , acetyl - CoA , pyruvate , and oxaloacetate .", "entity": [{"entity": "IclR", "entity_type": "GENE", "pos": [48, 52]}], "task": "NER"}
{"text": "Immunoprecipitation of spinophilin or neurabin from crude brain extracts selectively coprecipitated PP1gamma ( 1 ) over PP1beta .", "entity": [{"entity": "spinophilin", "entity_type": "GENE", "pos": [23, 34]}, {"entity": "neurabin", "entity_type": "GENE", "pos": [38, 46]}, {"entity": "PP1gamma ( 1 )", "entity_type": "GENE", "pos": [100, 114]}, {"entity": "PP1beta", "entity_type": "GENE", "pos": [120, 127]}], "task": "NER"}
{"text": "Most important , after all , is not the ionization technique but the stage with a 47 . 1 % five - year survival rate in T1N0 as compared to T2N0 with 28 . 6 % and T1N1 with 19 . 4 % .", "entity": [], "task": "NER"}
{"text": "The encoded Arabidopsis U3 snRNAs can be folded into a secondary structure which is more similar to that of U3 RNAs from lower eukaryotes rather than from metazoa .", "entity": [{"entity": "Arabidopsis U3 snRNAs", "entity_type": "GENE", "pos": [12, 33]}, {"entity": "U3 RNAs", "entity_type": "GENE", "pos": [108, 115]}], "task": "NER"}
{"text": "Cytokinetics of the Krebs 2 carcinoma .", "entity": [], "task": "NER"}
{"text": "We investigated whether two WT1 splice variants lacking or including a three - amino - acid ( KTS ) insertion between the third and fourth zinc finger in the DNA - binding domain could repress the IR promoter in vitro .", "entity": [{"entity": "WT1 splice variants", "entity_type": "GENE", "pos": [28, 47]}, {"entity": "IR promoter", "entity_type": "GENE", "pos": [197, 208]}], "task": "NER"}
{"text": "These back mutations led to a modest decrease in kinase activity , decreased tumorigenic potential in chickens , and an unexpected increase in transforming activity in rat cells .", "entity": [], "task": "NER"}
{"text": "Extragonadal endodermal sinus tumors in the head and neck are very rare .", "entity": [], "task": "NER"}
{"text": "Plasma NE and E increased to significantly higher values after 15 min in the young subjects : 1 . 68 + / - 0 . 18 vs .", "entity": [], "task": "NER"}
{"text": "Utility of thallium - 201 scintigraphy in detecting right ventricular dysfunction in pulmonary embolism .", "entity": [], "task": "NER"}
{"text": "E . granulosus infection has been confirmed in 25 patients ( 20 . 6 % ) , in 16 cases by finding parasite protoscoleces or hooks and in nine cases by detection of an antigen specific for E . granulosus , antigen 5 ( Ag5 ) .", "entity": [{"entity": "E . granulosus , antigen 5", "entity_type": "GENE", "pos": [187, 213]}, {"entity": "Ag5", "entity_type": "GENE", "pos": [216, 219]}], "task": "NER"}
{"text": "Transcription of FN promoter - chloramphenicol acetyltransferase fusion genes carrying the base substitution in one or more of these G - rich sequences both in vivo and in vitro revealed that the base substitution in any G - rich sequence results in reduction of promoter activity , although the downstream GC box ( GCd ) plays a primary role .", "entity": [{"entity": "FN promoter", "entity_type": "GENE", "pos": [17, 28]}, {"entity": "chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [31, 64]}], "task": "NER"}
{"text": "Teboroxime is a new boronic acid adduct of technetium dioxime ( BATO ) compound that demonstrates favorable characteristics in preliminary studies .", "entity": [], "task": "NER"}
{"text": "We tested several growth regulatory genes that are repressed in senescent cells for ability to restore activity to T [ K1 ] .", "entity": [{"entity": "T [ K1 ]", "entity_type": "GENE", "pos": [115, 123]}], "task": "NER"}
{"text": "It is our conclusion that Sonoclot coagulation analysis is unlikely to identify patients with prolonged bleeding time in whom platelet count and other coagulation factors are normal .", "entity": [], "task": "NER"}
{"text": "The single copy flotillin - 1 gene is located at 6p21 . 3 in the MHC class I region and consists of 13 exons over 15 kb .", "entity": [{"entity": "flotillin - 1 gene", "entity_type": "GENE", "pos": [16, 34]}, {"entity": "MHC class I region", "entity_type": "GENE", "pos": [65, 83]}], "task": "NER"}
{"text": "Low plasma glucose concentrations that may or may not be sufficiently low to result in symptoms can be observed as a concomitant of several diverse diseases .", "entity": [], "task": "NER"}
{"text": "However , patients with DPX should be observed for the potential occurrence of an associated condition .", "entity": [], "task": "NER"}
{"text": "The effects of castor oil , alone , as well as in combination with PGI2 and indomethacin on gastrointestinal functions have been examined in rats .", "entity": [], "task": "NER"}
{"text": "Effect of TNF , IL - 1 , and IL - 6 on the proliferation of human Tenon ' s capsule fibroblasts in tissue culture .", "entity": [{"entity": "TNF", "entity_type": "GENE", "pos": [10, 13]}, {"entity": "IL - 1", "entity_type": "GENE", "pos": [16, 22]}, {"entity": "IL - 6", "entity_type": "GENE", "pos": [29, 35]}], "task": "NER"}
{"text": "Previous analysis of this motif in the lactose permease ( A .", "entity": [{"entity": "lactose permease", "entity_type": "GENE", "pos": [39, 55]}], "task": "NER"}
{"text": "Also , the RVW hypertrophy , the IVS hypertrophy , and the RV high pressure load to the LV through the IVS may be related to the small LV , high EF , and abnormal two chamber inflow in the PS group before BV .", "entity": [], "task": "NER"}
{"text": "Several reports assert that prolactin affects the delta 5 and delta 4 pathways through its effect on the activity of 3beta - hydroxysteroid dehydrogenase ( 3beta - OHSD ) .", "entity": [{"entity": "prolactin", "entity_type": "GENE", "pos": [28, 37]}, {"entity": "3beta - hydroxysteroid dehydrogenase", "entity_type": "GENE", "pos": [117, 153]}, {"entity": "3beta - OHSD", "entity_type": "GENE", "pos": [156, 168]}], "task": "NER"}
{"text": "Acidosis provoked by 30 % CO2 irreversibly increased the BDRT , however the TRT were not changed .", "entity": [], "task": "NER"}
{"text": "In each study group , elevated levels of serum I were observed .", "entity": [], "task": "NER"}
{"text": "A decrease was also found of the levels of total cholesterol and LDL - cholesterol .", "entity": [{"entity": "LDL - cholesterol", "entity_type": "GENE", "pos": [65, 82]}], "task": "NER"}
{"text": "Sequencing of this fragment showed that the MRP13 coding region specifies a 324 - amino - acid basic protein with a calculated Mr of 37 , 366 .", "entity": [{"entity": "MRP13", "entity_type": "GENE", "pos": [44, 49]}], "task": "NER"}
{"text": "Low serum C3 values were observed in all 11 children at some stage of their illness .", "entity": [{"entity": "serum C3", "entity_type": "GENE", "pos": [4, 12]}], "task": "NER"}
{"text": "In spite of the presence of a physician , the real pathology of an indian population of Colombie is not very well known .", "entity": [], "task": "NER"}
{"text": "During chordotonal organ development , the 3 ' enhancer directs expression in proneural clusters ; whereas successive modular enhancers located in the 5 ' region drive tissue - specific expression in chordotonal organ precursors in the embryo and larval leg , wing and antennal imaginal discs .", "entity": [], "task": "NER"}
{"text": "Is conventional sperm analysis of any use ? The computerised records of 867 couples were used to investigate the prognostic significance of semen volume , motility , density and morphology .", "entity": [], "task": "NER"}
{"text": "The effect of guaiphenesin on absorption and bioavailability of paracetamol from composite analgesic preparations .", "entity": [], "task": "NER"}
{"text": "Detailed comparison of the urinary excretion of purines in a patient with the Lesch - Nyhan syndrome and a control subject .", "entity": [], "task": "NER"}
{"text": "Antisense oligonucleotides complementary to the 5 ' end of PKC - zeta mRNA sequences significantly reduced the collagen lattice - stimulated alpha2 and MMP - 1 mRNA levels .", "entity": [{"entity": "PKC - zeta mRNA sequences", "entity_type": "GENE", "pos": [59, 84]}, {"entity": "collagen", "entity_type": "GENE", "pos": [111, 119]}, {"entity": "MMP - 1 mRNA", "entity_type": "GENE", "pos": [152, 164]}], "task": "NER"}
{"text": "Furthermore , ERK phosphorylation was substantially prolonged in LC / BRY - treated cells compared to those exposed to BRY alone , and pretreatment with the highly specific MEK inhibitors , PD98059 , U0126 , and SL327 , opposed ERK activation while protecting cells from LC / BRY - induced lethality .", "entity": [{"entity": "ERK", "entity_type": "GENE", "pos": [14, 17]}, {"entity": "MEK", "entity_type": "GENE", "pos": [173, 176]}, {"entity": "ERK", "entity_type": "GENE", "pos": [228, 231]}], "task": "NER"}
{"text": "The most valid method was the AXB bearing with the cephalometric clinical diagnosis a 90 . 91 % concordance .", "entity": [], "task": "NER"}
{"text": "However , coligation of Fc gamma RIIB1 with B cell Ag receptors ( BCR ) inhibits BCR - mediated signaling by a mechanism that may involve recruitment of phosphatases SHP - 1 , SHP - 2 , and the SH2 containing inositol 5 ' phosphatase ( SHIP ) to the phosphorylated Fc gamma RIIB1 immunoreceptor tyrosine - based inhibitory motif .", "entity": [{"entity": "Fc gamma RIIB1", "entity_type": "GENE", "pos": [24, 38]}, {"entity": "B cell Ag receptors", "entity_type": "GENE", "pos": [44, 63]}, {"entity": "BCR", "entity_type": "GENE", "pos": [66, 69]}, {"entity": "BCR", "entity_type": "GENE", "pos": [81, 84]}, {"entity": "phosphatases SHP - 1", "entity_type": "GENE", "pos": [153, 173]}, {"entity": "SHP - 2", "entity_type": "GENE", "pos": [176, 183]}, {"entity": "SH2 containing inositol 5 ' phosphatase", "entity_type": "GENE", "pos": [194, 233]}, {"entity": "SHIP", "entity_type": "GENE", "pos": [236, 240]}, {"entity": "Fc gamma RIIB1 immunoreceptor tyrosine - based inhibitory motif", "entity_type": "GENE", "pos": [265, 328]}], "task": "NER"}
{"text": "At the first phase ( 1 - 43 ms for the VMN and 1 - 10 ms for the LN ) the hypothalamic - cortical responses completely inhibited the formation of the VC response to the light stimulus .", "entity": [], "task": "NER"}
{"text": "The slope of QD versus QEMF for the four tubes was near unity .", "entity": [], "task": "NER"}
{"text": "The sequence of the 127 residue NrfF polypeptide , M ( r ) 14 , 522 , is strikingly similar to the CcI2 protein of R . capsulatus , especially in the putative haem - binding motif , RCPQCQNQN . ( ABSTRACT TRUNCATED AT 400 WORDS )", "entity": [{"entity": "127 residue NrfF polypeptide , M ( r ) 14 , 522", "entity_type": "GENE", "pos": [20, 67]}, {"entity": "CcI2 protein", "entity_type": "GENE", "pos": [99, 111]}], "task": "NER"}
{"text": "When cotransfected with the HIV LTR CAT into CV - 1 cells , both the pCD41 and pGD41 clones trans - activated the HIV LTR .", "entity": [{"entity": "HIV LTR", "entity_type": "GENE", "pos": [28, 35]}, {"entity": "CAT", "entity_type": "GENE", "pos": [36, 39]}, {"entity": "pCD41", "entity_type": "GENE", "pos": [69, 74]}, {"entity": "pGD41", "entity_type": "GENE", "pos": [79, 84]}, {"entity": "HIV LTR", "entity_type": "GENE", "pos": [114, 121]}], "task": "NER"}
{"text": "From this comparison of aa sequences , the ATPK7 protein is considered to be a member of a novel subfamily of Ser / Thr PKs in plants .", "entity": [{"entity": "ATPK7 protein", "entity_type": "GENE", "pos": [43, 56]}, {"entity": "Ser / Thr PKs", "entity_type": "GENE", "pos": [110, 123]}], "task": "NER"}
{"text": "It is very probable that this change was due to mechanical effects induced by injecting a hypertonic solution of MT - 141 at a rate of 70 - - 130 ml / dog .", "entity": [], "task": "NER"}
{"text": "Both viruses express the mil / raf oncogene product as a gag - fusion polyprotein , while the myc oncogene of MH2 is expressed via a subgenomic mRNA .", "entity": [{"entity": "mil", "entity_type": "GENE", "pos": [25, 28]}, {"entity": "raf", "entity_type": "GENE", "pos": [31, 34]}, {"entity": "gag - fusion", "entity_type": "GENE", "pos": [57, 69]}, {"entity": "myc", "entity_type": "GENE", "pos": [94, 97]}], "task": "NER"}
{"text": "Furthermore the aldosterone stimulating effect of low sodium diet ( 17 children ) , severe and prolonged vomiting ( 19 children ) and synthetic ACTH ( 10 children ) has been studied by our modified method .", "entity": [{"entity": "ACTH", "entity_type": "GENE", "pos": [144, 148]}], "task": "NER"}
{"text": "Transmural metabolic heterogeneity at high cardiac work states .", "entity": [], "task": "NER"}
{"text": "A flow probe for direct measurement of blood flow of the mitral valve was devised .", "entity": [], "task": "NER"}
{"text": "The adoption of a twisted structure of importin - beta is essential for the protein - protein interaction required for nuclear transport .", "entity": [{"entity": "importin - beta", "entity_type": "GENE", "pos": [39, 54]}], "task": "NER"}
{"text": "Liver disease and HCV infection after transplantation of organs from hepatitis C antibody positive donors .", "entity": [{"entity": "hepatitis C antibody", "entity_type": "GENE", "pos": [69, 89]}], "task": "NER"}
{"text": "To investigate whether the two RPG - boxes mediate transcription activation of both the L46 and S24 gene , two experimental strategies were followed : cloning of the respective genes on multicopy vectors and construction of fusion genes .", "entity": [{"entity": "RPG - boxes", "entity_type": "GENE", "pos": [31, 42]}, {"entity": "L46", "entity_type": "GENE", "pos": [88, 91]}, {"entity": "S24 gene", "entity_type": "GENE", "pos": [96, 104]}], "task": "NER"}
{"text": "Electrophoretic mobility shift assays demonstrated that sequences within this region bind members of the Sp1 family of transcription factors .", "entity": [{"entity": "Sp1 family of transcription factors", "entity_type": "GENE", "pos": [105, 140]}], "task": "NER"}
{"text": "The prevalence of antibodies to HRES - 1 peptides pep14 - 24 and pep117 - 127 was determined in 65 normal blood donors and 146 patients with immunological disorders .", "entity": [{"entity": "HRES - 1 peptides pep14 - 24 and pep117 - 127", "entity_type": "GENE", "pos": [32, 77]}], "task": "NER"}
{"text": "SCOF - 1 localized to the nucleus but did not bind directly to either C - repeat / dehydration ( CRT / DRE ) or ABA responsive element ( ABRE ) , cis - acting DNA regulatory elements present in COR gene promoters .", "entity": [{"entity": "SCOF - 1", "entity_type": "GENE", "pos": [0, 8]}, {"entity": "COR gene promoters", "entity_type": "GENE", "pos": [194, 212]}], "task": "NER"}
{"text": "To date , 6 mammalian GRKs have been identified by molecular cloning .", "entity": [{"entity": "GRKs", "entity_type": "GENE", "pos": [22, 26]}], "task": "NER"}
{"text": "OBJECTIVE : To report a case of fulminant neuropathy with severe quadriparesis associated with vincristine chemotherapy .", "entity": [], "task": "NER"}
{"text": "The 1 . 5 - Mb region was covered by 137 cosmids with a minimum overlap set of 52 cosmids assigned to 17 bins and 9 contigs .", "entity": [], "task": "NER"}
{"text": "Homodimers of RIP60 ( replication initiation - region protein 60 kDA ) purified from nuclear extract bind two ATT - rich sites in oribeta and foster the formation of a twisted 720 bp DNA loop in vitro .", "entity": [{"entity": "RIP60", "entity_type": "GENE", "pos": [14, 19]}, {"entity": "replication initiation - region protein 60 kDA", "entity_type": "GENE", "pos": [22, 68]}], "task": "NER"}
{"text": "Effect of age on glucose , reducing sugars and plasma insulin in blood of milk - fed calves .", "entity": [{"entity": "plasma insulin", "entity_type": "GENE", "pos": [47, 61]}], "task": "NER"}
{"text": "Principal component analysis using psychosocial factors in women showed two psychosocial structures , i . e . the second principal ( high SOC , high lifestyle , and low stress ) and the 4th principal components ( high supernatural HLC , and high PHLC ) .", "entity": [], "task": "NER"}
{"text": "In response to acoustical stimulation the properties of response latency , discharge pattern , frequency tuning , binaural interaction , and habituation were examined to allow an appraisal of the differentiation of the MGB by electrophysiological means .", "entity": [], "task": "NER"}
{"text": "These two enhancer elements also enhanced transcription when fused separately to the basal promoter region of the chicken vimentin gene .", "entity": [{"entity": "chicken vimentin gene", "entity_type": "GENE", "pos": [114, 135]}], "task": "NER"}
{"text": "Availability of a less palatable diet ( chow ) following presentation of palatable diets will not result in diminished caloric intake , body weight , obesity and hyperinsulinemia .", "entity": [], "task": "NER"}
{"text": "Residues of Stauffer R - 3828 and its oxygen analogue in the body tissues of cattle fed R - 3828 in the diet .", "entity": [], "task": "NER"}
{"text": "Type II neuroleptanalgesia in odonto - stomatology", "entity": [], "task": "NER"}
{"text": "In addition , there was an increase in the amount of p120 Ras - specific GTPase - activating protein ( GAP ) and GAP - associated p190 .", "entity": [{"entity": "p120 Ras", "entity_type": "GENE", "pos": [53, 61]}, {"entity": "GTPase - activating protein", "entity_type": "GENE", "pos": [73, 100]}, {"entity": "GAP", "entity_type": "GENE", "pos": [103, 106]}, {"entity": "GAP", "entity_type": "GENE", "pos": [113, 116]}], "task": "NER"}
{"text": "OBJECTIVE : Respiratory - related electromyographic ( EMG ) activity of the superior pharyngeal constrictor ( SPC ) muscle was analyzed during the early stage of forced breathing .", "entity": [], "task": "NER"}
{"text": "Glutathione reductase activities in liver , kidney , lung , and brain were not affected by diet .", "entity": [{"entity": "Glutathione reductase", "entity_type": "GENE", "pos": [0, 21]}], "task": "NER"}
{"text": "LIP and DIP are less common IIPs , both characterized by ground - glass attenuation .", "entity": [], "task": "NER"}
{"text": "Healthy subjects received the following regimens , dosed to steady state : trovafloxacin 300 mg / 24 h ; ciprofloxacin 400 mg / 12 h ; trovafloxacin 300 mg / 24 h plus cefepime 2 g / 12 h , and ciprofloxacin 400 mg / 12 h plus cefepime 2 g / 12 h .", "entity": [], "task": "NER"}
{"text": "The data obtained with cellular RNA from HepG2 cells demonstrated that transcription is initiated 891 bases upstream of the translation - start site and that the polyadenylation site is located 550 bases downstream of the stop codon .", "entity": [], "task": "NER"}
{"text": "To investigate possible roles for HCP during late erythroid differentiation , effects of manipulating HCP expression or recruitment on EPO - induced hemoglobinization in erythroleukemic SKT6 cells have been investigated .", "entity": [{"entity": "HCP", "entity_type": "GENE", "pos": [34, 37]}, {"entity": "HCP", "entity_type": "GENE", "pos": [102, 105]}, {"entity": "EPO", "entity_type": "GENE", "pos": [135, 138]}], "task": "NER"}
{"text": "To investigate the role of bHLH proteins in MC3T3 - E1 osteoblasts , which undergo a developmental sequence in vitro , we analyzed the transcriptional control of osteocalcin gene expression by stable transfection of an osteocalcin promoter - luciferase chimeric gene ( p637OC - luc ) and assessed the role of E - box cis - acting elements in osteocalcin promoter by DNA binding assays .", "entity": [{"entity": "bHLH proteins", "entity_type": "GENE", "pos": [27, 40]}, {"entity": "osteocalcin gene", "entity_type": "GENE", "pos": [162, 178]}, {"entity": "osteocalcin promoter", "entity_type": "GENE", "pos": [219, 239]}, {"entity": "luciferase", "entity_type": "GENE", "pos": [242, 252]}, {"entity": "p637OC - luc", "entity_type": "GENE", "pos": [269, 281]}, {"entity": "osteocalcin promoter", "entity_type": "GENE", "pos": [342, 362]}], "task": "NER"}
{"text": "Genetic linkage mapping of the CYP11A1 gene encoding the cholesterol side - chain cleavage P450scc close to the CYP1A1 gene and D15S204 in the chromosome 15q22 . 33 - q23 region .", "entity": [{"entity": "CYP11A1 gene", "entity_type": "GENE", "pos": [31, 43]}, {"entity": "P450scc", "entity_type": "GENE", "pos": [91, 98]}, {"entity": "CYP1A1 gene", "entity_type": "GENE", "pos": [112, 123]}, {"entity": "D15S204", "entity_type": "GENE", "pos": [128, 135]}], "task": "NER"}
{"text": "Expression , characterization , and genomic structure of carp JAK1 kinase gene .", "entity": [{"entity": "carp JAK1 kinase gene", "entity_type": "GENE", "pos": [57, 78]}], "task": "NER"}
{"text": "Jornvall , B .", "entity": [], "task": "NER"}
{"text": "Three modern hematology analyzers ( Abbott Cell - Dyn 3000 , Coulter STKS , and Sysmex NE - 8000 ) with high throughput and 5 - part differential capability were evaluated using a protocol designed by a quality team .", "entity": [], "task": "NER"}
{"text": "Effect of prostaglandin E2 on experimental atherosclerosis .", "entity": [], "task": "NER"}
{"text": "The tro operon is flanked by a Holliday structure DNA helicase homolog ( upstream ) and two ORFs representing a purine nucleoside phosphorylase homolog and tpp15 , a previously characterized gene encoding a membrane lipoprotein ( downstream ) .", "entity": [{"entity": "tro operon", "entity_type": "GENE", "pos": [4, 14]}, {"entity": "Holliday structure DNA helicase", "entity_type": "GENE", "pos": [31, 62]}, {"entity": "purine nucleoside phosphorylase", "entity_type": "GENE", "pos": [112, 143]}, {"entity": "tpp15", "entity_type": "GENE", "pos": [156, 161]}], "task": "NER"}
{"text": "However , a few sites in the genomes of EC cells permit M - MuLVneo delta Enh proviral expression .", "entity": [{"entity": "M - MuLVneo delta Enh", "entity_type": "GENE", "pos": [56, 77]}], "task": "NER"}
{"text": "We have been developing a digital fluoroscopic imaging system to replace the portal films that are currently used to verify patient positioning during radiotherapy treatments .", "entity": [], "task": "NER"}
{"text": "We have utilized transient transfections , mutation analysis , electromobility gel - shifts , and immunoblot analysis to test the hypothesis that expression of the CTalpha gene is controlled in part by the binding of three trans - acting nuclear factors , Sp1 , Sp2 , and Sp3 .", "entity": [{"entity": "CTalpha gene", "entity_type": "GENE", "pos": [164, 176]}, {"entity": "Sp1", "entity_type": "GENE", "pos": [256, 259]}, {"entity": "Sp2", "entity_type": "GENE", "pos": [262, 265]}, {"entity": "Sp3", "entity_type": "GENE", "pos": [272, 275]}], "task": "NER"}
{"text": "Determinants of recurrent ischaemia and revascularisation procedures after thrombolysis with recombinant tissue plasminogen activator in primary coronary occlusion .", "entity": [{"entity": "tissue plasminogen activator", "entity_type": "GENE", "pos": [105, 133]}], "task": "NER"}
{"text": "Interestingly , unlike PAK65 , HPK1 does not contain the small GTPase Rac1 / Cdc42 - binding domain and does not bind to either Rac1 or Cdc42 , suggesting that HPK1 . activation is Rac1 / Cdc42 - independent .", "entity": [{"entity": "PAK65", "entity_type": "GENE", "pos": [23, 28]}, {"entity": "HPK1", "entity_type": "GENE", "pos": [31, 35]}, {"entity": "small GTPase", "entity_type": "GENE", "pos": [57, 69]}, {"entity": "Rac1", "entity_type": "GENE", "pos": [70, 74]}, {"entity": "Cdc42", "entity_type": "GENE", "pos": [77, 82]}, {"entity": "Rac1", "entity_type": "GENE", "pos": [128, 132]}, {"entity": "Cdc42", "entity_type": "GENE", "pos": [136, 141]}, {"entity": "HPK1", "entity_type": "GENE", "pos": [160, 164]}, {"entity": "Rac1", "entity_type": "GENE", "pos": [181, 185]}, {"entity": "Cdc42", "entity_type": "GENE", "pos": [188, 193]}], "task": "NER"}
{"text": "Transformations with circular plasmids yielded slowly and irregularly growing geneticin - resistant mycelia in which 1 % of nuclei contained plasmid sequences .", "entity": [], "task": "NER"}
{"text": "Using a combined pharmacokinetic - pharmacodynamic model , the impact of various factors on the effective bioavailability and on its estimation , using the intravenous - to - oral dose ratio required to produce the same area under the response time curve after acute administration , are explored .", "entity": [], "task": "NER"}
{"text": "We found that in anesthetized , paralyzed cats , the visual evoked potential ( VEP ) was dependent only on magnitude of delta C at each pattern transition , and was independent of the starting or ending contrast level .", "entity": [], "task": "NER"}
{"text": "Plasmid pSP64E6E7 which contains the reading frames of both E6 and E7 was constructed in order to study the expression of both proteins in a coupled transcription / rabbit reticulocyte translation system .", "entity": [{"entity": "E6", "entity_type": "GENE", "pos": [13, 15]}, {"entity": "E7", "entity_type": "GENE", "pos": [15, 17]}], "task": "NER"}
{"text": "A 99m Tc bone scan showed a focal area of an increased uptake at the site of the mass below the calcaneus .", "entity": [], "task": "NER"}
{"text": "In addition , FOP - FGFR1 - expressing cells show constitutive phosphorylation of the positive regulator of translation p70S6 kinase ; this phosphorylation is inhibited by PI3 - kinase and mTOR ( mammalian target of rapamycin ) inhibitors .", "entity": [{"entity": "FOP", "entity_type": "GENE", "pos": [14, 17]}, {"entity": "FGFR1", "entity_type": "GENE", "pos": [20, 25]}, {"entity": "p70S6 kinase", "entity_type": "GENE", "pos": [120, 132]}, {"entity": "PI3 - kinase", "entity_type": "GENE", "pos": [172, 184]}, {"entity": "mTOR", "entity_type": "GENE", "pos": [189, 193]}, {"entity": "mammalian target of rapamycin", "entity_type": "GENE", "pos": [196, 225]}], "task": "NER"}
{"text": "As a test of this hypothesis , we predicted that mice which have altered expression of class I gene products , the beta2 - microglobulin knockout mice , [ beta2m ( - / - ) ] , would develop Fe overload .", "entity": [{"entity": "beta2 - microglobulin", "entity_type": "GENE", "pos": [115, 136]}, {"entity": "[ beta2m ( - / - ) ]", "entity_type": "GENE", "pos": [153, 173]}], "task": "NER"}
{"text": "The synthesis of endo - adduct [ 4aS , 5S , 8R , 8aR , SS ] - 9d resulting from cycloaddition on the substituted C ( 2 ) - C ( 3 ) double bond was achieved in a chemo - and diastereoselective way from quinone 1d in the presence of ZnBr ( 2 ) .", "entity": [], "task": "NER"}
{"text": "Mad3 and Mad4 : novel Max - interacting transcriptional repressors that suppress c - myc dependent transformation and are expressed during neural and epidermal differentiation .", "entity": [{"entity": "Mad3", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "Mad4", "entity_type": "GENE", "pos": [9, 13]}, {"entity": "Max", "entity_type": "GENE", "pos": [22, 25]}, {"entity": "c - myc", "entity_type": "GENE", "pos": [81, 88]}], "task": "NER"}
{"text": "Maximal Expiratory Flow Rates such as Peak Expiratory Flow Rate ( PEFR ) , rates at 25 % , 50 % and 75 % of forced vital capacity ( V max 25 % , V max 50 % and V max 75 % ) and forced expiratory flow during the middle half of forced vital capacity ( FEF 25 - 75 % ) were measured in 273 healthy non - smoking adults ( 144 males , 129 females ) aged 15 - 63 years living in Madras .", "entity": [], "task": "NER"}
{"text": "This polypeptide includes the first three zinc fingers of the TFIIIA DNA binding domain .", "entity": [{"entity": "TFIIIA DNA binding domain", "entity_type": "GENE", "pos": [62, 87]}], "task": "NER"}
{"text": "Transcription of eukaryotic tRNA genes is dependent on the A - and B - Box internal control regions ( ICRs ) and the upstream transcription modulatory region .", "entity": [], "task": "NER"}
{"text": "This dose of Na3 citrate produced no clinical symptoms suggestive of hypocalcaemia in these subjects , even though the use of acid - citrate - dextrose , NIH formula A ( ACD - A ) under identical conditions has been reported to reduce significantly the level of total calcium in serum , and concomitantly increase the number or reactions occurring in donors .", "entity": [], "task": "NER"}
{"text": "Cough - CPR , a deep rhythmic forceful cough repeated 30 - 60 times per minute , can be an effective resuscitative technique during emergencies occurring in the cardiac catheterization laboratory .", "entity": [], "task": "NER"}
{"text": "The gene encoding the Neisseria lactamica III DNA methyltransferase ( M . NlaIII ) which recognizes the sequence CATG has been cloned and expressed in Escherichia coli .", "entity": [{"entity": "Neisseria lactamica III DNA methyltransferase", "entity_type": "GENE", "pos": [22, 67]}, {"entity": "M . NlaIII", "entity_type": "GENE", "pos": [70, 80]}], "task": "NER"}
{"text": "A multivariant study of pituitary adenoma , obtainment of two logistic regression equations as an auxiliary support in the diagnosis of these tumors .", "entity": [], "task": "NER"}
{"text": "Increased TRE DNA binding failed to lead to increased transactivation correlating with the inability of SB 203580 to increase phosphorylation of these AP - 1 proteins .", "entity": [{"entity": "AP - 1 proteins", "entity_type": "GENE", "pos": [151, 166]}], "task": "NER"}
{"text": "APL patients showed a low , yet variable , level of JEM - 1 mRNA in bone marrow .", "entity": [{"entity": "JEM - 1 mRNA", "entity_type": "GENE", "pos": [52, 64]}], "task": "NER"}
{"text": "The cDNA clones encode a polypeptide of 657 amino acids with a bHLH ( basic - helix - loop - helix ) domain , characteristic of a large family of transcription factors , and a PAS ( Per - Arnt - Sim ) domain in the amino - terminal half region .", "entity": [{"entity": "PAS", "entity_type": "GENE", "pos": [176, 179]}, {"entity": "Per", "entity_type": "GENE", "pos": [182, 185]}, {"entity": "Arnt", "entity_type": "GENE", "pos": [188, 192]}, {"entity": "Sim", "entity_type": "GENE", "pos": [195, 198]}], "task": "NER"}
{"text": "We propose that the cDNA encodes an apical plasma membrane protein that plays a role in the functional expression of the amiloride - sensitive epithelial sodium channel .", "entity": [], "task": "NER"}
{"text": "Nedocromil sodium shifted the severity of the early allergic reaction ( EAR ) from mean - 34 . 8 % to - 6 . 9 % and inhibited the later allergic reaction ( LAR ) from - 30 . 5 % to + 0 . 4 % ( p less than 0 . 005 ) .", "entity": [], "task": "NER"}
{"text": "Values of K1 and Vd were significantly increased in the tumour tissue .", "entity": [], "task": "NER"}
{"text": "The binding of PTB was antagonistic to the binding of U2AF to the enhancer - located pyrimidine tract .", "entity": [{"entity": "PTB", "entity_type": "GENE", "pos": [15, 18]}, {"entity": "U2AF", "entity_type": "GENE", "pos": [54, 58]}], "task": "NER"}
{"text": "Our results separate these factors into four regulatory classes : ( i ) constitutive factors , such as Oct - 1 and probably Sp1 , that are expressed in thymocytes at all stages ; ( ii ) inducible factors , such as NF - kappa B and complexes binding to the region of a CD28 response element , that can be activated in all thymocytes , including those cells ( CD4 + CD8 + TcRlow ) that can undergo selection ; ( iii ) inducible factors , such as NF - AT and AP - 1 , that can be activated in mature ( CD4 + CD8 - TcRhigh ) and immature ( CD4 - CD8 - TcR - ) thymocytes alike but not in the transitional stages when the cells ( CD4 + CD8 + TcRlow ) are subject to selection ; and ( iv ) a factor containing CREB , which can be activated in thymocytes of all developmental stages by culture but does not require specific induction .", "entity": [{"entity": "Oct - 1", "entity_type": "GENE", "pos": [103, 110]}, {"entity": "Sp1", "entity_type": "GENE", "pos": [124, 127]}, {"entity": "NF - kappa B", "entity_type": "GENE", "pos": [214, 226]}, {"entity": "CD28 response element", "entity_type": "GENE", "pos": [268, 289]}, {"entity": "CD4 +", "entity_type": "GENE", "pos": [358, 363]}, {"entity": "CD8 +", "entity_type": "GENE", "pos": [364, 369]}, {"entity": "TcRlow", "entity_type": "GENE", "pos": [370, 376]}, {"entity": "NF - AT", "entity_type": "GENE", "pos": [444, 451]}, {"entity": "AP - 1", "entity_type": "GENE", "pos": [456, 462]}, {"entity": "CD4 +", "entity_type": "GENE", "pos": [499, 504]}, {"entity": "CD8 -", "entity_type": "GENE", "pos": [505, 510]}, {"entity": "TcRhigh", "entity_type": "GENE", "pos": [511, 518]}, {"entity": "CD4 -", "entity_type": "GENE", "pos": [536, 541]}, {"entity": "CD8 -", "entity_type": "GENE", "pos": [542, 547]}, {"entity": "TcR -", "entity_type": "GENE", "pos": [548, 553]}, {"entity": "CD4 +", "entity_type": "GENE", "pos": [625, 630]}, {"entity": "CD8 +", "entity_type": "GENE", "pos": [631, 636]}, {"entity": "TcRlow", "entity_type": "GENE", "pos": [637, 643]}, {"entity": "CREB", "entity_type": "GENE", "pos": [704, 708]}], "task": "NER"}
{"text": "Similar tissue - specific patterns are observed with a fusion between the caufliflower mosaic virus 35S RNA promotor and the GUS gene .", "entity": [{"entity": "caufliflower mosaic virus 35S RNA promotor", "entity_type": "GENE", "pos": [74, 116]}, {"entity": "GUS gene", "entity_type": "GENE", "pos": [125, 133]}], "task": "NER"}
{"text": "The results obtained show that expression of the gene is low at 23 degrees C and is induced rapidly at 37 degrees C .", "entity": [], "task": "NER"}
{"text": "However , in each case in which either the DQ alpha - or DQ beta - chain was exchanged , major alterations or reversals of this pattern of interaction were observed .", "entity": [{"entity": "DQ alpha - or DQ beta - chain", "entity_type": "GENE", "pos": [43, 72]}], "task": "NER"}
{"text": "Two methods for the routine determination of blood hemoglobin oxygen affinity are described .", "entity": [{"entity": "hemoglobin", "entity_type": "GENE", "pos": [51, 61]}], "task": "NER"}
{"text": "The cause for the increase in plasma ANP levels in the active phase remains to be determined .", "entity": [{"entity": "plasma ANP", "entity_type": "GENE", "pos": [30, 40]}], "task": "NER"}
{"text": "The effects on survival of adjuvant treatments , including pre - or postoperative systemic or postoperative intra - arterial chemotherapy , are currently under evaluation .", "entity": [], "task": "NER"}
{"text": "Malformations of the regenerating optic tectum of larvae of the Egyptian toad , Bufo regularis Reuss .", "entity": [], "task": "NER"}
{"text": "Immunological studies also failed to demonstrate any significant change except for a significant increase of natural killer ( NK ) cell activity after IFN - gamma infusion .", "entity": [{"entity": "IFN - gamma", "entity_type": "GENE", "pos": [151, 162]}], "task": "NER"}
{"text": "We have used systemic application of the ototoxic drug amikacin , to induce total cochlear haircell loss in the chinchilla , in order to create an animal model of profound deafness .", "entity": [], "task": "NER"}
{"text": "BACKGROUND - - Platelet activating factor ( PAF ) has been implicated in the pathogenesis of airway hyperresponsiveness in asthma .", "entity": [{"entity": "Platelet activating factor", "entity_type": "GENE", "pos": [15, 41]}, {"entity": "PAF", "entity_type": "GENE", "pos": [44, 47]}], "task": "NER"}
{"text": "To be a nurse .", "entity": [], "task": "NER"}
{"text": "Chronic granulocytic leukemia in children .", "entity": [], "task": "NER"}
{"text": "Charcot joints .", "entity": [], "task": "NER"}
{"text": "Recombinant apoA - I protein recovered from the soluble fraction of the bacterial cell pellet was purified to greater than 95 % homogeneity by reversed - phase high - performance liquid chromatography .", "entity": [{"entity": "Recombinant apoA - I protein", "entity_type": "GENE", "pos": [0, 28]}], "task": "NER"}
{"text": "Kaposi ' s sarcoma - associated herpesvirus / human herpesvirus - 8 ORF50 gene product contains a potent C - terminal activation domain which activates gene expression via a specific target sequence .", "entity": [{"entity": "ORF50", "entity_type": "GENE", "pos": [68, 73]}], "task": "NER"}
{"text": "Comparison of the 5 ' flanking regions of the mouse J kappa elements , including the conserved putative recombination target sequences , shows no obvious differences consistent with the variation in recombinational efficiency , so we conclude that , although the consensus heptamer and nonamer signals may be sufficient to identify a recombination site , the probability that that site will be used depends also on other determinants .", "entity": [{"entity": "mouse J kappa elements", "entity_type": "GENE", "pos": [46, 68]}], "task": "NER"}
{"text": "Further interventions were : nephrectomy ( 2x ) , resection and ligation of the inferior vena cava ( 1x ) , resection and replacement of the left renal vein ( 1x ) .", "entity": [], "task": "NER"}
{"text": "Herein , we report that CRE - decoy oligonucleotide treatment results in an increase in the p53 protein level in MCF - 7 human breast cancer cells that express wild - type p53 .", "entity": [{"entity": "p53 protein", "entity_type": "GENE", "pos": [92, 103]}, {"entity": "p53", "entity_type": "GENE", "pos": [172, 175]}], "task": "NER"}
{"text": "Competition and methylation interference assays showed that the binding site for the novel factor was limited to nucleotides in the 3 ' half of the kappa B site .", "entity": [{"entity": "kappa B site", "entity_type": "GENE", "pos": [148, 160]}], "task": "NER"}
{"text": "We have introduced the same change in a yeast tRNA ( Trp ) gene and demonstrated that the tRNA acts as an efficient amber suppressor in vivo .", "entity": [{"entity": "yeast tRNA ( Trp ) gene", "entity_type": "GENE", "pos": [40, 63]}], "task": "NER"}
{"text": "Both proteins share sequence similarity with the myelin - associated glycoprotein , an adhesion molecule of oligodendrocytes and Schwann cells that has been implicated in the process of myelination , raising the important question of whether myelin - associated glycoprotein is also a sialic acid - binding protein .", "entity": [{"entity": "myelin - associated glycoprotein", "entity_type": "GENE", "pos": [49, 81]}, {"entity": "myelin - associated glycoprotein", "entity_type": "GENE", "pos": [242, 274]}, {"entity": "sialic acid - binding protein", "entity_type": "GENE", "pos": [285, 314]}], "task": "NER"}
{"text": "The predicted 5 ' and 3 ' ends of the transcript are in very good agreement with the previously determined size of the LEU3 message .", "entity": [{"entity": "LEU3", "entity_type": "GENE", "pos": [119, 123]}], "task": "NER"}
{"text": "These clones contain most of the exon of cyclin D2 except exon 5 .", "entity": [{"entity": "cyclin D2", "entity_type": "GENE", "pos": [41, 50]}], "task": "NER"}
{"text": "By 24 h , there was no significant difference in FFA levels from shams .", "entity": [], "task": "NER"}
{"text": "The clr1 locus regulates the expression of the cryptic mating - type loci of fission yeast .", "entity": [{"entity": "clr1 locus", "entity_type": "GENE", "pos": [4, 14]}, {"entity": "cryptic mating - type loci of fission yeast", "entity_type": "GENE", "pos": [47, 90]}], "task": "NER"}
{"text": "The odds of atopy ( defined as a positive test for at least one of the antigens ) were 5 times higher ( odds ratio = 7 . 0 ; 95 % confidence interval = 1 . 6 - 31 . 1 % ; p = 0 . 01 ) in the uninfected group , after taking into account the potential influence of gender and age .", "entity": [], "task": "NER"}
{"text": "In mouse , two high - affinity binding sites with an apparent dissociation constant ( Kd ) of 50 to 100 nM have been mapped in the 5 ' ETS upstream from the early pre - rRNA processing site .", "entity": [{"entity": "ETS", "entity_type": "GENE", "pos": [135, 138]}], "task": "NER"}
{"text": "As much thrombin was formed during cardiopulmonary bypass ( measured by the prothrombin activation fragment F1 + 2 and thrombin - antithrombin complexes ) as in normal patients , showing that factor XII was not necessary for thrombin generation .", "entity": [{"entity": "thrombin", "entity_type": "GENE", "pos": [8, 16]}, {"entity": "prothrombin activation fragment F1 + 2", "entity_type": "GENE", "pos": [76, 114]}, {"entity": "thrombin", "entity_type": "GENE", "pos": [119, 127]}, {"entity": "antithrombin", "entity_type": "GENE", "pos": [130, 142]}, {"entity": "factor XII", "entity_type": "GENE", "pos": [192, 202]}, {"entity": "thrombin", "entity_type": "GENE", "pos": [225, 233]}], "task": "NER"}
{"text": "This article reviews current concepts of pathophysiology and summarises clinical features , natural history and available treatments .", "entity": [], "task": "NER"}
{"text": "Pendulin , a Drosophila protein with cell cycle - dependent nuclear localization , is required for normal cell proliferation .", "entity": [{"entity": "Pendulin", "entity_type": "GENE", "pos": [0, 8]}], "task": "NER"}
{"text": "The phosphatase active site is located within residues 367 - 374 .", "entity": [], "task": "NER"}
{"text": "The central region of the sarcomere , coincident with the M line , was selectively labeled with antibodies to the short C - terminal form .", "entity": [], "task": "NER"}
{"text": "Moreover , antibody binding to the same two determinants was also inhibited when ZAP - 70 or the SH2 domains bound to the zeta chain or to a 2pY - ITAM .", "entity": [{"entity": "ZAP - 70", "entity_type": "GENE", "pos": [81, 89]}, {"entity": "SH2 domains", "entity_type": "GENE", "pos": [97, 108]}, {"entity": "2pY - ITAM", "entity_type": "GENE", "pos": [141, 151]}], "task": "NER"}
{"text": "Interleukin - 1 increased the noradrenaline release .", "entity": [{"entity": "Interleukin - 1", "entity_type": "GENE", "pos": [0, 15]}], "task": "NER"}
{"text": "A representative group of patients undergoing open radical nephrectomy for clinical T1 , T2 lesions was also identified .", "entity": [], "task": "NER"}
{"text": "These findings indicate that KCTG can contribute to improved monitoring in high - risk pregnancies .", "entity": [], "task": "NER"}
{"text": "These extrachromosomal copies can be isolated as covalently closed molecules with lengths around 3mu .", "entity": [], "task": "NER"}
{"text": "Significant reductions were noted in vertical GRFs per newton of body weight exerted at 10 % ( P = 0 . 0009 ) and 20 % ( P = 0 . 0383 ) of stance phase and in anteroposterior GRFs exerted at 10 % ( P = 0 . 0009 ) and 50 % ( P = 0 . 0033 ) of stance phase when ambulation was compared with and without the orthotic device .", "entity": [], "task": "NER"}
{"text": "Similar immunological disturbances were observed in SCI but not in the PC2 subgroup , i . e . patients examined later than 6 months after injury .", "entity": [], "task": "NER"}
{"text": "Trimethylcolchicinic acid methyl ether d - tartrate ( TMCA ; NSC - 36351 ) was administered daily by mouth to 71 patients with malignant lymphomas .", "entity": [], "task": "NER"}
{"text": "After multivariate analysis , TWA correlated with age ( P = 0 . 02 ) and LV function ( P = 0 . 002 ) and occurred more often in patients after nonanterior MI ( P = 0 . 03 ) .", "entity": [], "task": "NER"}
{"text": "In rats exposed to Cd for 30 d , the levels of urinary excretion of cAMP after treatment with parathyroid hormone ( PTH ) , parathyroidectomy ( PTX ) , or 1 alpha - hydroxycholecalciferol ( 1 alpha - OH - D3 ) showed almost the same patterns as those of control rats : the response of urinary cAMP to treatment with PTH was not influenced by continuous oral administration of Cd .", "entity": [{"entity": "parathyroid hormone", "entity_type": "GENE", "pos": [94, 113]}, {"entity": "PTH", "entity_type": "GENE", "pos": [116, 119]}, {"entity": "PTH", "entity_type": "GENE", "pos": [316, 319]}], "task": "NER"}
{"text": "Receptor - type serine / threonine kinases ( RSKs ) have been organized into two distinct classes known as types I and II on the basis of sequence similarity .", "entity": [{"entity": "Receptor - type serine / threonine kinases", "entity_type": "GENE", "pos": [0, 42]}, {"entity": "RSKs", "entity_type": "GENE", "pos": [45, 49]}], "task": "NER"}
{"text": "In the remaining 91 patients ( group 2 ) , Pseudomonas ( 18 ) , coagulase - negative Staphylococci ( 15 ) , Staphylococcus epidermidis ( 23 ) , Staphylococcus aureus ( 16 ) , Corynebacterium species ( 12 ) , and others ( seven ) were isolated .", "entity": [{"entity": "coagulase", "entity_type": "GENE", "pos": [64, 73]}], "task": "NER"}
{"text": "This cDNA corresponded to FGF - binding protein ( FGF - BP ) , a secreted protein previously shown to bind acidic and basic FGF and to modulate their activities .", "entity": [{"entity": "FGF - binding protein", "entity_type": "GENE", "pos": [26, 47]}, {"entity": "FGF - BP", "entity_type": "GENE", "pos": [50, 58]}, {"entity": "basic FGF", "entity_type": "GENE", "pos": [118, 127]}], "task": "NER"}
{"text": "Electrophoretic mobility - shift assays using oligonucleotides derived from these sites demonstrated formation of specific DNA - protein complexes .", "entity": [], "task": "NER"}
{"text": "For the P transcript from phage with the G ( - ) orientation , full termination activity required both the region containing the stem - loop structure and upstream sequences .", "entity": [{"entity": "P transcript", "entity_type": "GENE", "pos": [8, 20]}], "task": "NER"}
{"text": "One day after injection 48 % of the injected activity was in the skeleton , 9 . 3 % in the liver , 3 % in the kidneys and 4 . 4 % in the rest of the organs .", "entity": [], "task": "NER"}
{"text": "Of these four PP2C genes , the expression of the PP2Cbeta gene has been reported to be tissue - specific and development - dependent .", "entity": [{"entity": "PP2C genes", "entity_type": "GENE", "pos": [14, 24]}, {"entity": "PP2Cbeta gene", "entity_type": "GENE", "pos": [49, 62]}], "task": "NER"}
{"text": "Combined chemotherapy with VM 26 and BCNU for recurrent malignant gliomas after operation and irradiation .", "entity": [], "task": "NER"}
{"text": "Administration of FR 34235 reduced aortic blood pressure and increased cardiac output in anesthetized dogs with an ameroid - induced coronary artery occlusion .", "entity": [], "task": "NER"}
{"text": "Alternative immune globulin preparation when standard immune serum globulin is not available .", "entity": [{"entity": "immune globulin", "entity_type": "GENE", "pos": [12, 27]}, {"entity": "immune serum globulin", "entity_type": "GENE", "pos": [54, 75]}], "task": "NER"}
{"text": "Two sibs with identical features of short - limbed dwarfism , a normal skull and face and normal intelligence are described .", "entity": [], "task": "NER"}
{"text": "Effect of a high sugar intake on some metabolic and regulatory indicators in young men .", "entity": [], "task": "NER"}
{"text": "In the second group the untreated fellow eye was microscopically intact , but was shown ( as the treated eye ) to alter the concentration of uronic acid in different parts of the sclera .", "entity": [], "task": "NER"}
{"text": "Amplification of 4q21 - q22 and the MXR gene in independently derived mitoxantrone - resistant cell lines .", "entity": [{"entity": "MXR gene", "entity_type": "GENE", "pos": [36, 44]}], "task": "NER"}
{"text": "Expression of putative constitutively active forms of DdMEK1 in a ddmek1 null background is capable , at least partially , of complementing the small aggregate size defect and the ability to activate guanylyl cyclase .", "entity": [{"entity": "DdMEK1", "entity_type": "GENE", "pos": [54, 60]}, {"entity": "ddmek1", "entity_type": "GENE", "pos": [66, 72]}, {"entity": "guanylyl cyclase", "entity_type": "GENE", "pos": [200, 216]}], "task": "NER"}
{"text": "Quantitative Tl - 201 analysis after stress has also shown viable myocardium in most mild to moderate ( 51 % to 85 % of normal uptake ) irreversible Tl - 201 defects .", "entity": [], "task": "NER"}
{"text": "However , ADAR1 and the related deaminase ADAR2 showed significant expression in all regions of the brain examined , including cortex , hippocampus , olfactory bulb , and striatum , where the 5 - HT2CR pre - mRNA was extensively edited .", "entity": [{"entity": "ADAR1", "entity_type": "GENE", "pos": [10, 15]}, {"entity": "deaminase ADAR2", "entity_type": "GENE", "pos": [32, 47]}, {"entity": "5 - HT2CR pre - mRNA", "entity_type": "GENE", "pos": [192, 212]}], "task": "NER"}
{"text": "Psychophysical evidence is given for the existence of two distinct systems in human vision : a fast , sign - invariant system concerned with extracting contours and a slower , sign - sensitive system concerned with assigning surface color .", "entity": [], "task": "NER"}
{"text": "Five girls with Turner ' s syndrome aged 12 to 17 years showed LH values ( 5 . 0 - 14 . 5 IU / 12 h ) at the upper end of or slightly above the normal range and pathologically high values ( 22 . 2 - 43 . 5 IU / 12 h ) for FSH .", "entity": [{"entity": "LH", "entity_type": "GENE", "pos": [63, 65]}, {"entity": "FSH", "entity_type": "GENE", "pos": [222, 225]}], "task": "NER"}
{"text": "Thirty - seven patients with severe temporal lobe epilepsy were studied interictally with [ 18F ] fluorodeoxyglucose - PET in each of three conditions : resting , during emotional speech , and while performing a visual recognition task .", "entity": [], "task": "NER"}
{"text": "The sequence of Vac1p contains two putative zinc - binding RING motifs , a zinc finger motif , and a coiled - coil motif .", "entity": [{"entity": "Vac1p", "entity_type": "GENE", "pos": [16, 21]}], "task": "NER"}
{"text": "Serum concentrations of hormones in patients classified as C were characteristically and inclined to be hypergonadotropic and hypoestrogenic .", "entity": [], "task": "NER"}
{"text": "Kinase renaturation tests designed to detect reactivated protein kinases after electrophoresis in sodium dodecyl sulfate - polyacrylamide gels revealed the presence of a 60 - kDa kinase in the washed immunoprecipitate obtained from liver cytosol using anti - AHR antibody ( IgG ) and protein A / G / agarose beads but not when a nonspecific IgG was used instead of anti - AHR antibody .", "entity": [{"entity": "anti - AHR antibody", "entity_type": "GENE", "pos": [252, 271]}, {"entity": "IgG", "entity_type": "GENE", "pos": [274, 277]}, {"entity": "IgG", "entity_type": "GENE", "pos": [341, 344]}, {"entity": "anti - AHR antibody", "entity_type": "GENE", "pos": [365, 384]}], "task": "NER"}
{"text": "The immune response seems to be partially responsible for both protection and the destructive consequences of chlamydial infection .", "entity": [], "task": "NER"}
{"text": "Activated FGFR3 predominantly interacts with GRB2 . Sos in complex with a previously identified 90 - kDa protein and designated protein 80K - H .", "entity": [{"entity": "FGFR3", "entity_type": "GENE", "pos": [10, 15]}, {"entity": "GRB2 . Sos", "entity_type": "GENE", "pos": [45, 55]}, {"entity": "protein 80K - H", "entity_type": "GENE", "pos": [128, 143]}], "task": "NER"}
{"text": "We generated \" signature \" oligonucleotides from these CDR3s and probed PCR amplified V kappa products from the synovium and PBLs of the same patient , and from PBLs and spleen of individuals without rheumatic disease .", "entity": [{"entity": "CDR3s", "entity_type": "GENE", "pos": [55, 60]}, {"entity": "V kappa products", "entity_type": "GENE", "pos": [86, 102]}], "task": "NER"}
{"text": "It was predicted that the Stroop task would trigger greater consumption of ice cream than a fearful film , and that this effect would be more pronounced for binge - eaters than non - binge - eaters .", "entity": [], "task": "NER"}
{"text": "Patients with PLM show excessive daytime sleepiness or insomnia .", "entity": [], "task": "NER"}
{"text": "Plasma colony - stimulating factor analysis and the clinical significance", "entity": [{"entity": "Plasma colony - stimulating factor", "entity_type": "GENE", "pos": [0, 34]}], "task": "NER"}
{"text": "Structure and regulation of KGD2 , the structural gene for yeast dihydrolipoyl transsuccinylase .", "entity": [{"entity": "KGD2", "entity_type": "GENE", "pos": [28, 32]}, {"entity": "yeast dihydrolipoyl transsuccinylase", "entity_type": "GENE", "pos": [59, 95]}], "task": "NER"}
{"text": "We identified two potential phosphorylation sites at serine49 and serine133 , both of which seem to be necessary for Myf - 5 activity .", "entity": [{"entity": "Myf - 5", "entity_type": "GENE", "pos": [117, 124]}], "task": "NER"}
{"text": "Exposure of raft cultures to activators of protein kinase C , such as phorbol esters , results in the further induction of late gene expression as well as virion assembly .", "entity": [{"entity": "protein kinase C", "entity_type": "GENE", "pos": [43, 59]}, {"entity": "late gene", "entity_type": "GENE", "pos": [123, 132]}], "task": "NER"}
{"text": "Here we demonstrate that the T cell antigen receptor zeta - chain - associated ZAP - 70 kinase and T cell antigen receptor zeta - chain immunoreceptor tyrosine - based activation motifs are essential for the membrane recruitment of SOS and Vav .", "entity": [{"entity": "T cell antigen receptor zeta - chain - associated ZAP - 70 kinase", "entity_type": "GENE", "pos": [29, 94]}, {"entity": "T cell antigen receptor zeta - chain immunoreceptor tyrosine - based activation motifs", "entity_type": "GENE", "pos": [99, 185]}, {"entity": "SOS", "entity_type": "GENE", "pos": [232, 235]}, {"entity": "Vav", "entity_type": "GENE", "pos": [240, 243]}], "task": "NER"}
{"text": "Above this transition temperature the calcium antagonist lowers fm more pronouncedly than below .", "entity": [], "task": "NER"}
{"text": "Behavioral effects of benzodiazepine ligands in non - dependent , diazepam - dependent and diazepam - withdrawn baboons .", "entity": [], "task": "NER"}
{"text": "Gastrointestinal accumulation of indium - 111 labelled granulocytes in reactive arthritis .", "entity": [], "task": "NER"}
{"text": "TNF - alpha stimulated these changes in part by increasing transcription and stabilization of RNA for amphiregulin , an EGF receptor ligand , and amphiregulin directly increased HPV - 16 E6 / E7 and cyclin A RNAs .", "entity": [{"entity": "TNF - alpha", "entity_type": "GENE", "pos": [0, 11]}, {"entity": "amphiregulin", "entity_type": "GENE", "pos": [102, 114]}, {"entity": "EGF receptor", "entity_type": "GENE", "pos": [120, 132]}, {"entity": "amphiregulin", "entity_type": "GENE", "pos": [146, 158]}, {"entity": "E6", "entity_type": "GENE", "pos": [187, 189]}, {"entity": "E7", "entity_type": "GENE", "pos": [192, 194]}, {"entity": "cyclin A RNAs", "entity_type": "GENE", "pos": [199, 212]}], "task": "NER"}
{"text": "The JNK / SAPK activator mixed lineage kinase 3 ( MLK3 ) transforms NIH 3T3 cells in a MEK - dependent fashion .", "entity": [{"entity": "JNK", "entity_type": "GENE", "pos": [4, 7]}, {"entity": "SAPK", "entity_type": "GENE", "pos": [10, 14]}, {"entity": "mixed lineage kinase 3", "entity_type": "GENE", "pos": [25, 47]}, {"entity": "MLK3", "entity_type": "GENE", "pos": [50, 54]}, {"entity": "MEK", "entity_type": "GENE", "pos": [87, 90]}], "task": "NER"}
{"text": "Biochemical analyses revealed that the concentration of norepinephrine was reduced significantly in cortex - hippocampus and olfactory bulb but not in other regions , while dopamine and serotonin levels were not altered in any brain region examined .", "entity": [], "task": "NER"}
{"text": "A mouth asymmetry study .", "entity": [], "task": "NER"}
{"text": "Control oligomers of scrambled sequence but identical base composition were ineffective , and no TFO - induced recombination was seen in a control LTK ( - ) cell line carrying an otherwise identical dual TK gene construct lacking the 30 - bp polypurine target site .", "entity": [{"entity": "TK gene construct", "entity_type": "GENE", "pos": [204, 221]}], "task": "NER"}
{"text": "Transformation of chicken embryo fibroblasts ( CEF ) with the Gag - Crk fusion protein results in the elevation of tyrosine phosphorylation on specific cellular proteins with molecular weights of 130 , 000 , 110 , 000 , and 70 , 000 ( p130 , p110 , and p70 , respectively ) , an event which has been correlated with cell transformation .", "entity": [{"entity": "Gag", "entity_type": "GENE", "pos": [62, 65]}, {"entity": "Crk", "entity_type": "GENE", "pos": [68, 71]}, {"entity": "p130", "entity_type": "GENE", "pos": [235, 239]}, {"entity": "p110", "entity_type": "GENE", "pos": [242, 246]}, {"entity": "p70", "entity_type": "GENE", "pos": [253, 256]}], "task": "NER"}
{"text": "Tilisolol and carboxymethylcellulose sodium salt ( CMC ) were used as the model ophthalmic drug and viscous polymer , respectively .", "entity": [], "task": "NER"}
{"text": "OAT has become safer in recent years , particularly if monitored in special anticoagulation clinics .", "entity": [], "task": "NER"}
{"text": "The results were compared with the findings in pair - fed non - treated animals ( Control Group ) .", "entity": [], "task": "NER"}
{"text": "Our data are in line with the hypothesis that E2F functions as a growth - and cell cycle regulated tethering factor between Sp1 and the basic transcription machinery .", "entity": [{"entity": "E2F", "entity_type": "GENE", "pos": [46, 49]}, {"entity": "Sp1", "entity_type": "GENE", "pos": [124, 127]}], "task": "NER"}
{"text": "Fetal transplants rescue axial muscle representations in M1 cortex of neonatally transected rats that develop weight support .", "entity": [], "task": "NER"}
{"text": "However , to encourage good contact between the farmers and the inseminating personnel , it is beneficial that herdsmen are present when cows are inseminated .", "entity": [], "task": "NER"}
{"text": "Solution of the Boltzmann equation in a random magnetic field .", "entity": [], "task": "NER"}
{"text": "These include the genes , undefined 1 ( UD1 ) , UD2 , and UD3 , each coding for proteins of unknown function , the ken gene encoding a new Kruppel - like putative transcription factor , the fly homologues of the mammalian mitochondrial trifunctional enzyme ( thiolase ) , and the TAR DNA - binding protein - 43 ( TBPH ) , the first nonvertebrate member of the transmembrane 4 superfamily ( TM4SF ) gene , a new homeodomain gene , and a gene coding for a putative nuclear binding protein ( PNBP ) that is homologous to maleless , and a Copia - like element .", "entity": [{"entity": "undefined 1", "entity_type": "GENE", "pos": [26, 37]}, {"entity": "UD1", "entity_type": "GENE", "pos": [40, 43]}, {"entity": "UD2", "entity_type": "GENE", "pos": [48, 51]}, {"entity": "UD3", "entity_type": "GENE", "pos": [58, 61]}, {"entity": "ken gene", "entity_type": "GENE", "pos": [115, 123]}, {"entity": "Kruppel - like putative transcription factor", "entity_type": "GENE", "pos": [139, 183]}, {"entity": "mammalian mitochondrial trifunctional enzyme", "entity_type": "GENE", "pos": [212, 256]}, {"entity": "thiolase", "entity_type": "GENE", "pos": [259, 267]}, {"entity": "TAR DNA - binding protein - 43", "entity_type": "GENE", "pos": [280, 310]}, {"entity": "TBPH", "entity_type": "GENE", "pos": [313, 317]}, {"entity": "transmembrane 4 superfamily", "entity_type": "GENE", "pos": [360, 387]}, {"entity": "TM4SF", "entity_type": "GENE", "pos": [390, 395]}, {"entity": "homeodomain gene", "entity_type": "GENE", "pos": [411, 427]}, {"entity": "maleless", "entity_type": "GENE", "pos": [518, 526]}, {"entity": "Copia - like element", "entity_type": "GENE", "pos": [535, 555]}], "task": "NER"}
{"text": "It is recommended that area correction be attempted in bioequivalence studies of drugs where high intrasubject variability in clearance is known or suspected .", "entity": [], "task": "NER"}
{"text": "A method for determining the toxicity of neutralizers for antimicrobial agents to A . castellanii was also evaluated .", "entity": [], "task": "NER"}
{"text": "In the present study we use a tnaC - UGA - ' lacZ construct lacking the tnaC - tnaA spacer region to analyze the effect of TnaC synthesis on the behavior of the ribosome that translates tnaC .", "entity": [{"entity": "tnaC", "entity_type": "GENE", "pos": [30, 34]}, {"entity": "' lacZ", "entity_type": "GENE", "pos": [43, 49]}, {"entity": "tnaC", "entity_type": "GENE", "pos": [72, 76]}, {"entity": "tnaA", "entity_type": "GENE", "pos": [79, 83]}, {"entity": "TnaC", "entity_type": "GENE", "pos": [123, 127]}, {"entity": "tnaC", "entity_type": "GENE", "pos": [186, 190]}], "task": "NER"}
{"text": "Unlike JNK activation , ERK activation could not be mapped to specific reovirus gene segments , suggesting that ERK activation and JNK activation are triggered by different events during virus - host cell interaction .", "entity": [{"entity": "JNK", "entity_type": "GENE", "pos": [7, 10]}, {"entity": "ERK", "entity_type": "GENE", "pos": [24, 27]}, {"entity": "ERK", "entity_type": "GENE", "pos": [112, 115]}, {"entity": "JNK", "entity_type": "GENE", "pos": [131, 134]}], "task": "NER"}
{"text": "Promoter region of the human alpha 2A adrenergic receptor gene .", "entity": [{"entity": "human alpha 2A adrenergic receptor gene", "entity_type": "GENE", "pos": [23, 62]}], "task": "NER"}
{"text": "Analysis of deletion and substitution mutations in the MER2 5 ' exon demonstrates that the unusually large size of this exon plays an important role in splicing regulation .", "entity": [{"entity": "MER2 5 ' exon", "entity_type": "GENE", "pos": [55, 68]}], "task": "NER"}
{"text": "Schottky - barrier heights of Ti and TiSi2 on n - type and p - type Si ( 100 ) .", "entity": [], "task": "NER"}
{"text": "In - 111 - BLMC uptake was directly proportional to Ki - 67 / MIB - 1 activity and number of mitoses in tumor tissue .", "entity": [{"entity": "Ki - 67", "entity_type": "GENE", "pos": [52, 59]}, {"entity": "MIB - 1", "entity_type": "GENE", "pos": [62, 69]}], "task": "NER"}
{"text": "The majority of the human Ig heavy chain ( IgH ) constant ( C ) region locus has been cloned and mapped .", "entity": [{"entity": "human Ig heavy chain ( IgH ) constant ( C ) region locus", "entity_type": "GENE", "pos": [20, 76]}], "task": "NER"}
{"text": "On guanidine and the treatment of botulism .", "entity": [], "task": "NER"}
{"text": "Excellent results were recorded in 390 ( 83 . 69 % ) of the patients , improvement in 46 ( 9 . 87 % ) where in the majority a varicose complex was involved .", "entity": [], "task": "NER"}
{"text": "By differential screening of a Xenopus laevis egg cDNA library , we have isolated a 2 , 111 bp cDNA which corresponds to a maternal mRNA specifically deadenylated after fertilisation .", "entity": [], "task": "NER"}
{"text": "Most of these elements are adjacent to type X telomeric repeats , and regions flanking four of five characterized S . paradoxus insertions carry autonomously replicating sequences .", "entity": [], "task": "NER"}
{"text": "Mutational analysis of the putative effector domain of the GTP - binding Ypt1 protein in yeast suggests specific regulation by a novel GAP activity .", "entity": [{"entity": "GTP - binding Ypt1 protein", "entity_type": "GENE", "pos": [59, 85]}, {"entity": "GAP", "entity_type": "GENE", "pos": [135, 138]}], "task": "NER"}
{"text": "We recently described the isolation and characterization of nontoxic PAP mutants , NT123 - 2 , which has a point mutation ( E176V ) in the active site that abolishes enzymatic activity , and NT124 - 3 , which has a nonsense mutation that results in deletion of the C - terminal 25 aa ( W237Stop ) .", "entity": [{"entity": "PAP mutants", "entity_type": "GENE", "pos": [69, 80]}], "task": "NER"}
{"text": "This ligand - independent pathway can function through another androgen - regulated promoter as shown by the use of the mouse mammary tumor virus MMTV - CAT reporter .", "entity": [{"entity": "mouse mammary tumor virus MMTV - CAT reporter", "entity_type": "GENE", "pos": [120, 165]}], "task": "NER"}
{"text": "From the present results a concept of hormone - dependent AR activation is proposed , which requires a functional , direct or indirect intramolecular interaction between the TAD and the LBD .", "entity": [{"entity": "AR", "entity_type": "GENE", "pos": [58, 60]}], "task": "NER"}
{"text": "All patients were peritonitis - free at least 6 weeks before each PET .", "entity": [], "task": "NER"}
{"text": "After control for body mass index , trait anxiety and anger - in remained independent predictors of diastolic blood pressure among the women .", "entity": [], "task": "NER"}
{"text": "Studies on low - dose oral contraceptives : cervical mucus and plasma hormone changes in relation to circulating D - norgestrel and 17alpha ethynyl - estradiol concentrations .", "entity": [], "task": "NER"}
{"text": "The predicted vav oncogene protein sequence exhibits several motifs reminiscent of transcriptional factors .", "entity": [{"entity": "vav oncogene protein sequence", "entity_type": "GENE", "pos": [14, 43]}], "task": "NER"}
{"text": "The platelet membrane glycoprotein IIb / IIIa receptor inhibitor abciximab is used for the treatment of patients undergoing high - risk percutaneous coronary interventions and is used in approximately one third of coronary interventions in the United States and a growing number of procedures in Europe .", "entity": [{"entity": "platelet membrane glycoprotein IIb / IIIa receptor", "entity_type": "GENE", "pos": [4, 54]}], "task": "NER"}
{"text": "The mean times to LNR in these groups were 42 . 0 months ( range , 3 . 0 - 194 . 5 months ) and 49 . 0 months ( range , 3 . 6 - 209 . 0 months ) respectively .", "entity": [], "task": "NER"}
{"text": "Ultraviolet crosslinking experiments using element B revealed the specific binding of two proteins of approximately 43 and 80 kDa .", "entity": [], "task": "NER"}
{"text": "The cells were densely ciliated , each cilium showing a typical 9 + 2 fibrilar pattern .", "entity": [], "task": "NER"}
{"text": "Searching the human DNA data base of expressed sequence tags ( EST ) revealed novel partial sequences similar to , but distinct from , the sequences of the previously known PEF proteins .", "entity": [{"entity": "PEF proteins", "entity_type": "GENE", "pos": [173, 185]}], "task": "NER"}
{"text": "HBO had marked effects on these enzymes : lung SOD increased ( guinea pigs 47 % , rats 88 % ) and CAT and GSHPx activities decreased ( 33 % ) in brain and lung .", "entity": [{"entity": "lung SOD", "entity_type": "GENE", "pos": [42, 50]}, {"entity": "CAT", "entity_type": "GENE", "pos": [98, 101]}, {"entity": "GSHPx", "entity_type": "GENE", "pos": [106, 111]}], "task": "NER"}
{"text": "RXRalpha / RARalpha heterodimers and HNF - 4 homodimers bind to DR - 1 motifs on elements B and I4 , respectively .", "entity": [{"entity": "RXRalpha", "entity_type": "GENE", "pos": [0, 8]}, {"entity": "RARalpha", "entity_type": "GENE", "pos": [11, 19]}, {"entity": "HNF - 4 homodimers", "entity_type": "GENE", "pos": [37, 55]}], "task": "NER"}
{"text": "Adenomas in the upper gastrointestinal tract were found in all of the patients : Vater ' s papilla - - 12 , duodenum - - nine , and gastric antrum - - seven .", "entity": [], "task": "NER"}
{"text": "A new direct hemagglutination test ( HI - GONAVIS ) for urinary LH was compared with the serum radioimmuno - assay of LH .", "entity": [{"entity": "LH", "entity_type": "GENE", "pos": [64, 66]}, {"entity": "LH", "entity_type": "GENE", "pos": [118, 120]}], "task": "NER"}
{"text": "Sucrose produced in source leaves is the predominant carbon source for developing sink tissues in most higher plants .", "entity": [], "task": "NER"}
{"text": "Accumulation of amines in the isolated perfused rabbit lung .", "entity": [], "task": "NER"}
{"text": "They also show that M . malmoense can be isolated from the environment which may be the source of the infection .", "entity": [], "task": "NER"}
{"text": "On the pharmacology of 9 , 10 - dihydro - 10 - ( 1 - methyl - 4 - piperidylidene ) - 9 - anthrol ( WA 335 ) , a histamine and serotonin antagonist", "entity": [], "task": "NER"}
{"text": "This incompatibility phenotype requires the global transcriptional repressor , KorB , and the target for incC - mediated incompatibility is a KorB - binding site ( O ( B ) ) .", "entity": [{"entity": "KorB", "entity_type": "GENE", "pos": [79, 83]}, {"entity": "incC", "entity_type": "GENE", "pos": [105, 109]}, {"entity": "KorB - binding site ( O ( B ) )", "entity_type": "GENE", "pos": [142, 173]}], "task": "NER"}
{"text": "Therefore , a structural interaction between PsaL and PsaI may stabilize the association of PsaL with the photosystem I core .", "entity": [{"entity": "PsaL", "entity_type": "GENE", "pos": [45, 49]}, {"entity": "PsaI", "entity_type": "GENE", "pos": [54, 58]}, {"entity": "PsaL", "entity_type": "GENE", "pos": [92, 96]}, {"entity": "photosystem I core", "entity_type": "GENE", "pos": [106, 124]}], "task": "NER"}
{"text": "Binding of the TorR regulator to cis - acting direct repeats activates tor operon expression .", "entity": [{"entity": "TorR regulator", "entity_type": "GENE", "pos": [15, 29]}, {"entity": "tor operon", "entity_type": "GENE", "pos": [71, 81]}], "task": "NER"}
{"text": "Histological and immunophenotypic studies revealed 12 large cell lymphomas ( 11 B cell and one T cell ) , two small noncleaved cell lymphomas ( B - cell phenotype ) , and five low grade B - cell lymphomas ( two small lymphocytic and three follicular mixed lymphomas ) .", "entity": [], "task": "NER"}
{"text": "The subjects were 17 patients with android obesity ( four men and 13 women ) aged 21 to 58 years with a body mass index ( BMI ) ranging from 32 . 0 to 52 . 2 kg / m2 and an abdominal - gluteal ratio greater than 1 . 0 .", "entity": [], "task": "NER"}
{"text": "A mean value for HbA1 greater than 10 % was associated with an increased risk of progression of retinopathy and a mean value less than 8 . 7 % was associated with a diminished risk .", "entity": [{"entity": "HbA1", "entity_type": "GENE", "pos": [17, 21]}], "task": "NER"}
{"text": "An emended diagnosis of Tylocephalum is proposed excluding this feature , along with distribution of the testes in the preovarian field and circummedullary distribution of vitelline follicles .", "entity": [], "task": "NER"}
{"text": "Role of double - stranded RNA - dependent protein kinase in mediating hypersensitivity of Fanconi anemia complementation group C cells to interferon gamma , tumor necrosis factor - alpha , and double - stranded RNA .", "entity": [{"entity": "double - stranded RNA - dependent protein kinase", "entity_type": "GENE", "pos": [8, 56]}, {"entity": "interferon gamma", "entity_type": "GENE", "pos": [138, 154]}, {"entity": "tumor necrosis factor - alpha", "entity_type": "GENE", "pos": [157, 186]}], "task": "NER"}
{"text": "Different effects of reoxygenation on the electrical activity of ventricular muscle .", "entity": [], "task": "NER"}
{"text": "Similar observations were obtained when these mutated versions of site A were evaluated by transient cotransfection assays in CV1 cells .", "entity": [], "task": "NER"}
{"text": "YLL031c is an essential gene .", "entity": [{"entity": "YLL031c", "entity_type": "GENE", "pos": [0, 7]}], "task": "NER"}
{"text": "We have measured percentage O3 uptake in 30 adult Sprague - Dawley rats exposed , nose only , for 1 hr to 0 . 3 , 0 . 6 , or 1 . 0 ppm O3 .", "entity": [], "task": "NER"}
{"text": "Threefold risks were observed for men with the highest level of intensity and for those with the highest probability of EMF exposure , although women with heavy EMF exposure did not experience increased risk .", "entity": [], "task": "NER"}
{"text": "Further , cells cotransfected with a UF promoter - luciferase ( - 1935UF - Luc ) reporter gene and the BTEB expression vector had 2 - fold higher Luc activity than those cotransfected with reporter gene and pcDNA - 3 .", "entity": [{"entity": "UF promoter", "entity_type": "GENE", "pos": [37, 48]}, {"entity": "luciferase", "entity_type": "GENE", "pos": [51, 61]}, {"entity": "1935UF", "entity_type": "GENE", "pos": [66, 72]}, {"entity": "Luc", "entity_type": "GENE", "pos": [75, 78]}, {"entity": "BTEB", "entity_type": "GENE", "pos": [103, 107]}, {"entity": "Luc", "entity_type": "GENE", "pos": [146, 149]}], "task": "NER"}
{"text": "Early complement components , C1q and C4 , and IgA secretory piece were absent .", "entity": [{"entity": "C1q", "entity_type": "GENE", "pos": [30, 33]}, {"entity": "C4", "entity_type": "GENE", "pos": [38, 40]}, {"entity": "IgA", "entity_type": "GENE", "pos": [47, 50]}], "task": "NER"}
{"text": "Although IRS - 1 , - 2 , and - 4 are similar in overall structure , IRS - 3 is approximately 50 % shorter and differs with respect to sites of tyrosine phosphorylation .", "entity": [{"entity": "IRS - 1 , - 2 , and - 4", "entity_type": "GENE", "pos": [9, 32]}, {"entity": "IRS - 3", "entity_type": "GENE", "pos": [68, 75]}], "task": "NER"}
{"text": "These results demonstrate a specific association of SIV and HIV - 2 nef , but not HIV - 1 nef , with TCRzeta .", "entity": [{"entity": "HIV - 2 nef", "entity_type": "GENE", "pos": [60, 71]}, {"entity": "HIV - 1 nef", "entity_type": "GENE", "pos": [82, 93]}, {"entity": "TCRzeta", "entity_type": "GENE", "pos": [101, 108]}], "task": "NER"}
{"text": "METHODS : We retrospectively analyzed the data of 20 patients who underwent both gated fluorine 18 deoxyglucose ( FDG ) - PET and equilibrium radionuclide angiography ( ERNA ) .", "entity": [], "task": "NER"}
{"text": "The distinct spatial pattern of expression , and unusual amino acid sequence in its DNA binding domain , may indicate a particular role for DTEF - 1 in cell - specific gene regulation .", "entity": [{"entity": "DTEF - 1", "entity_type": "GENE", "pos": [140, 148]}], "task": "NER"}
{"text": "Rac2 , a member of the Rho family of GTPases , is highly expressed in myeloid cells and is a regulator of the NADPH - oxidase complex .", "entity": [{"entity": "Rac2", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "Rho family", "entity_type": "GENE", "pos": [23, 33]}, {"entity": "GTPases", "entity_type": "GENE", "pos": [37, 44]}, {"entity": "NADPH - oxidase complex", "entity_type": "GENE", "pos": [110, 133]}], "task": "NER"}
{"text": "The yeast mitochondrial Hsp70 , Ssc1p , functions as a molecular chaperone with its partner proteins , Mdj1p ( DnaJ homologue ) and Yge1p ( GrpE homologue ) .", "entity": [{"entity": "yeast mitochondrial Hsp70", "entity_type": "GENE", "pos": [4, 29]}, {"entity": "Ssc1p", "entity_type": "GENE", "pos": [32, 37]}, {"entity": "Mdj1p", "entity_type": "GENE", "pos": [103, 108]}, {"entity": "DnaJ homologue", "entity_type": "GENE", "pos": [111, 125]}, {"entity": "Yge1p", "entity_type": "GENE", "pos": [132, 137]}, {"entity": "GrpE homologue", "entity_type": "GENE", "pos": [140, 154]}], "task": "NER"}
{"text": "The best sequences for pelvic study are , in our experience , IR or short TR spin - echo for T1 - weighted images , and spin - echo with 1200 TR for T2 images .", "entity": [], "task": "NER"}
{"text": "We now report that both HSCR mutations impair the fixation of Shc to RET and consequently prevent its phosphorylation .", "entity": [{"entity": "HSCR", "entity_type": "GENE", "pos": [24, 28]}, {"entity": "Shc", "entity_type": "GENE", "pos": [62, 65]}, {"entity": "RET", "entity_type": "GENE", "pos": [69, 72]}], "task": "NER"}
{"text": "We now describe a HepG2 cell casein kinase II beta subunit cDNA of 2 . 57 kb containing 96 bases of 5 ' untranslated sequence , 645 bases of open reading frame , and 1832 bases of 3 ' untranslated sequence with two polyadenylation consensus signal sequences and two poly ( A ) stretches .", "entity": [{"entity": "HepG2 cell casein kinase II beta subunit cDNA", "entity_type": "GENE", "pos": [18, 63]}], "task": "NER"}
{"text": "Platelet factor 4 levels in patients with coronary artery disease .", "entity": [{"entity": "Platelet factor 4", "entity_type": "GENE", "pos": [0, 17]}], "task": "NER"}
{"text": "Serum pituitary and steroid hormone levels in the adult male : one value is as good as the mean of three .", "entity": [], "task": "NER"}
{"text": "Blood ammonia concentration was significantly higher in males at 70 , 80 and 90 % of VO2 peak .", "entity": [], "task": "NER"}
{"text": "Here , we describe the crystal structure at 2 . 5 A resolution of a fragment of the integrase of Rous sarcoma virus ( residues 49 - 286 ) containing both the conserved catalytic domain and a modulatory DNA - binding domain ( C domain ) .", "entity": [{"entity": "integrase of Rous sarcoma virus ( residues 49 - 286 )", "entity_type": "GENE", "pos": [84, 137]}], "task": "NER"}
{"text": "The effect on kidney length was considerably prolonged compared with the vascular effect .", "entity": [], "task": "NER"}
{"text": "The prevalence of microalbuminuria , defined as an UAER in the range of 15 - 150 micrograms min - 1 in an overnight urine sample , was 3 % ( 95 % C . I . interval : 1 . 9 - 4 . 0 ) .", "entity": [], "task": "NER"}
{"text": "However , a lesser extent effect was noticed in nonpregnant than seen in pregnant rats .", "entity": [], "task": "NER"}
{"text": "Despite their high degree of sequence similarity , all five RFC genes are essential for cell proliferation in S . cerevisiae .", "entity": [{"entity": "RFC genes", "entity_type": "GENE", "pos": [60, 69]}], "task": "NER"}
{"text": "Rev .", "entity": [], "task": "NER"}
{"text": "The strongly DNA binding p50 subunit showed only very weak , if any , induction of gene expression .", "entity": [{"entity": "p50 subunit", "entity_type": "GENE", "pos": [25, 36]}], "task": "NER"}
{"text": "Stability of 125 I - labeled insulin used in radioimmunoassay of insulin .", "entity": [{"entity": "insulin", "entity_type": "GENE", "pos": [29, 36]}, {"entity": "insulin", "entity_type": "GENE", "pos": [65, 72]}], "task": "NER"}
{"text": "Influence of long - term zimelidine treatment on LSD - induced behavioural effects .", "entity": [], "task": "NER"}
{"text": "Using mammalian expression vectors ( pRSV - neo and pSV2 - neo ) , antisense constructs for perforin and granzyme B were independently electroporated into YT - INDY , a human non - MHC - restricted , IL - 2 - independent , cytotoxic lymphocyte .", "entity": [{"entity": "perforin", "entity_type": "GENE", "pos": [92, 100]}, {"entity": "granzyme B", "entity_type": "GENE", "pos": [105, 115]}, {"entity": "MHC", "entity_type": "GENE", "pos": [181, 184]}, {"entity": "IL - 2", "entity_type": "GENE", "pos": [200, 206]}], "task": "NER"}
{"text": "When targeted to the GAL1 promoter by fusing with the Gal4p DNA - binding domain , Sko1p acts as an Ssn6 / Tup1p - dependent repressor regulated by osmotic stress .", "entity": [{"entity": "GAL1 promoter", "entity_type": "GENE", "pos": [21, 34]}, {"entity": "Gal4p DNA - binding domain", "entity_type": "GENE", "pos": [54, 80]}, {"entity": "Sko1p", "entity_type": "GENE", "pos": [83, 88]}, {"entity": "Ssn6", "entity_type": "GENE", "pos": [100, 104]}, {"entity": "Tup1p", "entity_type": "GENE", "pos": [107, 112]}], "task": "NER"}
{"text": "Like Rev - Erb , BD73 binds as a monomer to a DNA sequence which consists of a specific A / T - rich sequence upstream of the consensus hexameric half - site specified by the P box of the DNA - binding domain .", "entity": [{"entity": "Rev", "entity_type": "GENE", "pos": [5, 8]}, {"entity": "Erb", "entity_type": "GENE", "pos": [11, 14]}, {"entity": "BD73", "entity_type": "GENE", "pos": [17, 21]}], "task": "NER"}
{"text": "BACKGROUND : Allergic rhinoconjunctivitis is a common disorder , affecting > 20 % of people of all socioeconomic strata .", "entity": [], "task": "NER"}
{"text": "INTERVENTIONS : Postoperative follow - up consisted of serial determination of different biochemical markers ( CK , CK - MB , cTnI ) , ECGs , and echocardiography .", "entity": [{"entity": "CK", "entity_type": "GENE", "pos": [111, 113]}, {"entity": "CK - MB", "entity_type": "GENE", "pos": [116, 123]}, {"entity": "cTnI", "entity_type": "GENE", "pos": [126, 130]}], "task": "NER"}
{"text": "The striking similarity in preference for mismatched and weakly paired nucleotides for binding and for excision suggests a functional relationship between binding and cleavage reactions .", "entity": [], "task": "NER"}
{"text": "New results of importance for optimization of the postoperative course ] Complications after major surgery may be related to factors in the surgical stress response with endocrine - metabolic and inflammatory changes .", "entity": [], "task": "NER"}
{"text": "Immunoblotting showed that both the ( 1 - 404 ) - peptide and ( 1 - 506 ) - peptide are recognized by 95J10 , a monoclonal antibody that was previously raised against perlecan - ( 24 - 404 ) - peptide expressed in Escherichia coli .", "entity": [{"entity": "95J10", "entity_type": "GENE", "pos": [102, 107]}, {"entity": "perlecan - ( 24 - 404 ) - peptide", "entity_type": "GENE", "pos": [167, 200]}], "task": "NER"}
{"text": "Tumor necrosis factor levels were measured by enzyme - linked immunoabsorbent assay in plasma samples obtained from the hyperthermic isolated limb perfusion circuit and systemic circulation .", "entity": [{"entity": "Tumor necrosis factor", "entity_type": "GENE", "pos": [0, 21]}], "task": "NER"}
{"text": "Serum alpha - amylase , trypsin , trypsin inhibitor , lipase and total protease activity in the pancreatic tissue was studied as indicator of the treatment efficacy with 5 - fluorouracil electro - cumulation .", "entity": [{"entity": "Serum alpha - amylase", "entity_type": "GENE", "pos": [0, 21]}, {"entity": "trypsin", "entity_type": "GENE", "pos": [24, 31]}, {"entity": "trypsin inhibitor", "entity_type": "GENE", "pos": [34, 51]}, {"entity": "lipase", "entity_type": "GENE", "pos": [54, 60]}], "task": "NER"}
{"text": "The possible equivalency of a short form and the long form of the Multiple Affect Adjective Check List - Revised ( MAACL - R ; Zuckerman & Lubin , 1985 ) was studied by correlating both forms of the MAACL - R with the State Trait Personality Inventory ( Spielberger , 1995 ) ; the Affect Balance Scale ( Bradburn , 1969 ) ; and the Sensation Seeking Scale ( Zuckerman , 1978 ) .", "entity": [], "task": "NER"}
{"text": "The activity of platelet factor 4 in plasma of healthy and high risk newborns .", "entity": [{"entity": "platelet factor 4", "entity_type": "GENE", "pos": [16, 33]}], "task": "NER"}
{"text": "Studies of HS2 - gamma gene reporter constructs carrying CACCC box deletions revealed that the CACCC box sequence of the gamma gene promoter mediates the activation of the gamma gene by FKLF .", "entity": [{"entity": "HS2 - gamma gene reporter constructs", "entity_type": "GENE", "pos": [11, 47]}, {"entity": "FKLF", "entity_type": "GENE", "pos": [186, 190]}], "task": "NER"}
{"text": "In addition , mrp17 - 1 , in combination with some mutations affecting another mitochondrial ribosomal protein , caused a synthetic defective phenotype .", "entity": [{"entity": "mrp17 - 1", "entity_type": "GENE", "pos": [14, 23]}], "task": "NER"}
{"text": "Erdheim - Chester disease : a distinct lipoidosis or part of the spectrum of histiocytosis ? Erdheim - Chester disease has always been considered a distinct lipoidosis based on clinical and radiographic criteria .", "entity": [], "task": "NER"}
{"text": "The ossification was located on the left side of C3 - 4 .", "entity": [], "task": "NER"}
{"text": "Characterization of human activating transcription factor 4 , a transcriptional activator that interacts with multiple domains of cAMP - responsive element - binding protein ( CREB ) - binding protein .", "entity": [{"entity": "human activating transcription factor 4", "entity_type": "GENE", "pos": [20, 59]}, {"entity": "cAMP - responsive element - binding protein", "entity_type": "GENE", "pos": [130, 173]}, {"entity": "CREB", "entity_type": "GENE", "pos": [176, 180]}], "task": "NER"}
{"text": "If the size of the cystic liver - lesions excludes a curative operative treatment or if the patient refuses surgery , the indication for chemotherapy with mebendazole is given .", "entity": [], "task": "NER"}
{"text": "The Ixodes fauna in the Michourin region , where the pastures in 1971 were grazed only by sheep , shows the following trends : H . punctata and R . turanicus ticks , which are preferably parasitising in sheep , increase their relative share .", "entity": [], "task": "NER"}
{"text": "The contribution of residues outside the Ras binding domain of Raf ( RafRBD ) to Ras - Raf interaction and Ras - dependent Raf activation has remained unresolved .", "entity": [{"entity": "Ras binding domain", "entity_type": "GENE", "pos": [41, 59]}, {"entity": "Raf", "entity_type": "GENE", "pos": [63, 66]}, {"entity": "RafRBD", "entity_type": "GENE", "pos": [69, 75]}, {"entity": "Ras", "entity_type": "GENE", "pos": [81, 84]}, {"entity": "Raf", "entity_type": "GENE", "pos": [87, 90]}, {"entity": "Ras", "entity_type": "GENE", "pos": [107, 110]}, {"entity": "Raf", "entity_type": "GENE", "pos": [123, 126]}], "task": "NER"}
{"text": "We suggest that electrical stimulation of the NTS in rats undergoing such surgical preparation to observe the pressor response and / or increase in pVP , represents a rapid approach for screening the neurosecretory function of the central neural integration to release vasopressin .", "entity": [{"entity": "vasopressin", "entity_type": "GENE", "pos": [269, 280]}], "task": "NER"}
{"text": "CONCLUSION / INTERPRETATION : We found an increased risk of hip fracture in women younger than 75 years with Type I diabetes or with Type II diabetes of long duration .", "entity": [], "task": "NER"}
{"text": "Mean 24 h urinary excretion values confirmed this observation .", "entity": [], "task": "NER"}
{"text": "Here we investigate the mechanism of TPA induction of FGF - BP gene expression in the human ME - 180 SCC cell line .", "entity": [{"entity": "FGF - BP", "entity_type": "GENE", "pos": [54, 62]}], "task": "NER"}
{"text": "They represent a physiologically more meaningful pattern than the arithmetic mean with standard deviation .", "entity": [], "task": "NER"}
{"text": "The influence of gas composition in the air cell on pipping and liver metabolism in embryonic chicks .", "entity": [], "task": "NER"}
{"text": "However , FosB - L and FosB - S do not differ in all trans - regulatory properties : Trans - activation of a 5x TRE - CAT reporter construct in HeLa and NIH - 3T3 cells was found with both FosB forms .", "entity": [{"entity": "FosB - L", "entity_type": "GENE", "pos": [10, 18]}, {"entity": "FosB - S", "entity_type": "GENE", "pos": [23, 31]}, {"entity": "TRE - CAT", "entity_type": "GENE", "pos": [112, 121]}, {"entity": "FosB", "entity_type": "GENE", "pos": [189, 193]}], "task": "NER"}
{"text": "Numerous genes of this family have been identified in animals , with the largest number found in vertebrates .", "entity": [], "task": "NER"}
{"text": "Mineralized bone nodule formation in vitro by cell populations from young adult rabbit alveolar bone .", "entity": [], "task": "NER"}
{"text": "Soluble extracts from FGF - treated as compared with quiescent fibroblasts exhibited up to 3 - fold higher kinase activity towards S6 in exogenously added rat liver 40S ribosomes and a synthetic peptide , RRLSSLRA .", "entity": [{"entity": "FGF", "entity_type": "GENE", "pos": [22, 25]}, {"entity": "S6", "entity_type": "GENE", "pos": [131, 133]}, {"entity": "rat liver 40S ribosomes", "entity_type": "GENE", "pos": [155, 178]}], "task": "NER"}
{"text": "In conclusion , when pulmonary abnormalities are found in HTLV - 1 carriers , we should be careful in determining whether such pulmonary involvements are etiologically related to HTLV - 1 infection .", "entity": [], "task": "NER"}
{"text": "We found that 48 % of the patients had their thoracolumbar blood supply based on two anterior radiculospinal arteries the lowest of which was located at , or lower than , T12 , and the second and higher one between T6 and T10 .", "entity": [], "task": "NER"}
{"text": "Cross - species characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene reveals multiple levels of regulation .", "entity": [{"entity": "promoter region of the cystic fibrosis transmembrane conductance regulator gene", "entity_type": "GENE", "pos": [40, 119]}], "task": "NER"}
{"text": "The leader peptide was hypothesized to inhibit ribosome release at the tnaC stop codon , thereby blocking Rho ' s access to the transcript .", "entity": [{"entity": "tnaC stop codon", "entity_type": "GENE", "pos": [71, 86]}, {"entity": "Rho", "entity_type": "GENE", "pos": [106, 109]}], "task": "NER"}
{"text": "We have isolated a unique murine FLT3 cDNA that codes for a variant isoform of FLT3 , devoid of the fifth Ig - like domain , by comparison with the prototypic form .", "entity": [{"entity": "murine FLT3 cDNA", "entity_type": "GENE", "pos": [26, 42]}, {"entity": "FLT3", "entity_type": "GENE", "pos": [79, 83]}, {"entity": "Ig - like domain", "entity_type": "GENE", "pos": [106, 122]}], "task": "NER"}
{"text": "Thus , 22 % of MDS responded to oral PLAC .", "entity": [], "task": "NER"}
{"text": "Plasma beta - thromboglobulin ( beta - TG ) , a platelet - specific protein , is a marker of intravascular platelet degranulation .", "entity": [{"entity": "Plasma beta - thromboglobulin", "entity_type": "GENE", "pos": [0, 29]}, {"entity": "beta - TG", "entity_type": "GENE", "pos": [32, 41]}], "task": "NER"}
{"text": "The Synechococcus gene rps1 encoding S1 is located 1 . 1 kb downstream from psbB , which encodes the photosystem II P680 chlorophyll a apoprotein .", "entity": [{"entity": "Synechococcus gene rps1", "entity_type": "GENE", "pos": [4, 27]}, {"entity": "S1", "entity_type": "GENE", "pos": [37, 39]}, {"entity": "psbB", "entity_type": "GENE", "pos": [76, 80]}, {"entity": "photosystem II P680 chlorophyll a apoprotein", "entity_type": "GENE", "pos": [101, 145]}], "task": "NER"}
{"text": "Additions of NH4 + up to 200 micrograms 1 ( - 1 ) were not stimulatory , whereas at 1 . 0 mg 1 ( - 1 ) levels , Ke was 50 % greater than for NO3 - enriched medium .", "entity": [], "task": "NER"}
{"text": "Pretreatment with lipid X was not necessary to improve survival : 16 of 17 ( 94 % ) infected and visibly ill animals that received lipid X and ticarcillin 6 h after thigh inoculation survived versus 30 of 44 ( 68 % ) control animals treated with ticarcillin alone ( P less than 0 . 0001 ) .", "entity": [], "task": "NER"}
{"text": "Between 1988 and 1994 , data from 3 large sites revealed a 3 - 5 fold increase in the prevalence of antidepressant ( ATD ) treatment for U . S . youths aged 2 - 19 years .", "entity": [], "task": "NER"}
{"text": "RESULTS : Analysis by Pearson ' s correlation showed that the subjects who had higher scores of SSMS during the drum rotation generated the following : a ) a higher rating of over - all sickness ( r = 0 . 76 ) ; b ) a higher ratio of spectral power of EGG at 4 - 9 cycles per minute ( cpm ) between drum rotation and baseline periods ( r = 0 . 63 ) ; c ) a higher net percent increase of spectral power in the EEG frequency band 0 . 5 - 4 Hz between drum rotation and baseline periods on C3 ( r = 0 . 29 ) and C4 ( r = 0 . 31 ) ; d ) a higher ratio of spectral power of EEG frequency band 0 . 5 - 4 Hz between drum rotation and baseline periods on C3 ( r = 0 . 31 ) ; and e ) a higher level of net increase in skin conductance from baseline to drum rotation ( r = 0 . 30 ) .", "entity": [], "task": "NER"}
{"text": "After inhibition of monoamine oxidase with pargyline ( 10 mg / kg . i . v . ) , the effects of tyramine ( 1000 micrograms ) injected into the hepatic artery were potentiated .", "entity": [{"entity": "monoamine oxidase", "entity_type": "GENE", "pos": [20, 37]}], "task": "NER"}
{"text": "However , the addition of intravenous injection of FPFD 101 resulted in a marked improvement in their symptoms .", "entity": [], "task": "NER"}
{"text": "We report that Gcn5 , a histone H3 acetylase , plays a central role in initiation of meiosis via effects on IME2 expression .", "entity": [{"entity": "Gcn5", "entity_type": "GENE", "pos": [15, 19]}, {"entity": "histone H3 acetylase", "entity_type": "GENE", "pos": [24, 44]}, {"entity": "IME2", "entity_type": "GENE", "pos": [108, 112]}], "task": "NER"}
{"text": "In the presence of high concentrations ( propofol 100 microg mL - 1 , thiopental 50 microg mL - 1 ) marked relaxation was observed ( propofol - 32 % up to - 49 % , P < 0 , 05 ; thiopental - 23 % up to - 67 % , P < 0 . 05 ) .", "entity": [], "task": "NER"}
{"text": "In further support of the biological significance of these DNA - protein interactions , the IL2RA oligonucleotide from - 291 to - 245 proved to be sufficient in either orientation to confer PMA inducibility to the mitogen - insensitive thymidine kinase gene promoter in Jurkat cells .", "entity": [{"entity": "IL2RA", "entity_type": "GENE", "pos": [92, 97]}, {"entity": "thymidine kinase gene promoter", "entity_type": "GENE", "pos": [236, 266]}], "task": "NER"}
{"text": "The amino acid residues and subdomains important for DNA binding , hormone binding , dimerization , and transactivation are mostly conserved among all VDR species .", "entity": [{"entity": "VDR", "entity_type": "GENE", "pos": [151, 154]}], "task": "NER"}
{"text": "Here , we describe the nucleotide ( nt ) sequence and genomic organization of ipiB and ipiO .", "entity": [{"entity": "ipiB", "entity_type": "GENE", "pos": [78, 82]}, {"entity": "ipiO", "entity_type": "GENE", "pos": [87, 91]}], "task": "NER"}
{"text": "Specifically , we demonstrate that this 25 - base pair region mediates the up - regulatory effect of TGF - beta on COL1A2 promoter activity and allows antagonistic activity of TNF - alpha on the TGF - beta effect .", "entity": [{"entity": "TGF - beta", "entity_type": "GENE", "pos": [101, 111]}, {"entity": "COL1A2 promoter", "entity_type": "GENE", "pos": [115, 130]}, {"entity": "TNF - alpha", "entity_type": "GENE", "pos": [176, 187]}, {"entity": "TGF - beta", "entity_type": "GENE", "pos": [195, 205]}], "task": "NER"}
{"text": "The phosphatidylglycerol / phosphatidylinositol transfer protein ( PG / PI - TP ) is a new and original phospholipid transfer protein ( PLTP ) isolated from the Deuteromycete , Aspergillus oryzae .", "entity": [{"entity": "phosphatidylglycerol / phosphatidylinositol transfer protein", "entity_type": "GENE", "pos": [4, 64]}, {"entity": "PG / PI - TP", "entity_type": "GENE", "pos": [67, 79]}, {"entity": "phospholipid transfer protein", "entity_type": "GENE", "pos": [104, 133]}, {"entity": "PLTP", "entity_type": "GENE", "pos": [136, 140]}], "task": "NER"}
{"text": "A 5789 - nucleotide - long EcoRI fragment from the genome of Thermotoga maritima , identified by cross - hybridization to L11 , L1 , L10 , and L12 ribosomal protein gene sequences from Escherichia coli , was cloned and sequenced .", "entity": [{"entity": "5789 - nucleotide - long EcoRI fragment", "entity_type": "GENE", "pos": [2, 41]}, {"entity": "L11", "entity_type": "GENE", "pos": [122, 125]}, {"entity": "L1", "entity_type": "GENE", "pos": [128, 130]}, {"entity": "L10", "entity_type": "GENE", "pos": [133, 136]}, {"entity": "L12 ribosomal protein gene sequences from Escherichia coli", "entity_type": "GENE", "pos": [143, 201]}], "task": "NER"}
{"text": "Endotoxemia and bacteremia in patients with sepsis syndrome in the intensive care unit .", "entity": [], "task": "NER"}
{"text": "Several 35 - mm slides of dystrophin - , laminin - , and concanavalin A ( ConA ) - stained muscle sections were used to calculate myofiber cross - sectional areas and to compare different techniques and settings of an image capture system .", "entity": [{"entity": "dystrophin", "entity_type": "GENE", "pos": [26, 36]}, {"entity": "laminin", "entity_type": "GENE", "pos": [41, 48]}, {"entity": "concanavalin A", "entity_type": "GENE", "pos": [57, 71]}, {"entity": "ConA", "entity_type": "GENE", "pos": [74, 78]}], "task": "NER"}
{"text": "Indeed , after a single oral dose , the role of the mu - receptor agonist component of the antinociceptive effect of tramadol appears to be minor , with most of the analgesic effect being attributable to nonopioid properties of the parent compound .", "entity": [{"entity": "mu - receptor", "entity_type": "GENE", "pos": [52, 65]}], "task": "NER"}
{"text": "The mRNA for this protein is expressed in the T - ALL cell line Jurkat and has been designated HUG1 , for HOX11 Upstream Gene .", "entity": [{"entity": "HUG1", "entity_type": "GENE", "pos": [95, 99]}, {"entity": "HOX11 Upstream Gene", "entity_type": "GENE", "pos": [106, 125]}], "task": "NER"}
{"text": "In solution , [ ( 125 ) I ] - labeled ankyrin was found by ND - PAGE3 to enhance the affinity of spectrin self - association by 10 - fold .", "entity": [{"entity": "ankyrin", "entity_type": "GENE", "pos": [38, 45]}, {"entity": "spectrin", "entity_type": "GENE", "pos": [97, 105]}], "task": "NER"}
{"text": "The MEF - 2 proteins are a family of transcriptional activators that have been detected in a wide variety of cell types .", "entity": [{"entity": "MEF - 2 proteins", "entity_type": "GENE", "pos": [4, 20]}], "task": "NER"}
{"text": "Jet lag and melatonin .", "entity": [], "task": "NER"}
{"text": "Manual sample clean - up procedures as well as the addition of an internal standard are not needed .", "entity": [], "task": "NER"}
{"text": "Treatment of diabetes and retinal complications", "entity": [], "task": "NER"}
{"text": "In contrast , an N - terminal RNAP mutant that has a decreased capacity to bind single - stranded RNA forms halted complexes with much lower levels of stability than the WT enzyme , and these complexes are not stabilized by the presence of the NT strand .", "entity": [{"entity": "N - terminal RNAP mutant", "entity_type": "GENE", "pos": [17, 41]}], "task": "NER"}
{"text": "The densities ranged between 2 and 3976 neurites / mm2 skin surface , but the overlap between subjects and without PHN was small .", "entity": [], "task": "NER"}
{"text": "The present study demonstrates that the proto - oncogene c - jun represses transcription of the human CG alpha and CG beta promoters . c - Jun repressed the CG alpha promoter through a canonical cAMP response element ( CRE ) that is known to bind c - Jun and other members of the B - Zip transcription factor family .", "entity": [{"entity": "proto - oncogene c - jun", "entity_type": "GENE", "pos": [40, 64]}, {"entity": "human CG alpha", "entity_type": "GENE", "pos": [96, 110]}, {"entity": "CG beta promoters", "entity_type": "GENE", "pos": [115, 132]}, {"entity": "c - Jun", "entity_type": "GENE", "pos": [135, 142]}, {"entity": "CG alpha promoter", "entity_type": "GENE", "pos": [157, 174]}, {"entity": "c - Jun", "entity_type": "GENE", "pos": [247, 254]}, {"entity": "B - Zip transcription factor family", "entity_type": "GENE", "pos": [280, 315]}], "task": "NER"}
{"text": "The mouse lactoferrin gene promoter was active in human endometrium carcinoma RL 95 - 2 cells and in rat glioma C6 cells .", "entity": [{"entity": "lactoferrin", "entity_type": "GENE", "pos": [10, 21]}], "task": "NER"}
{"text": "This is the first report that the PH domain of an IRS protein can function in a dominant negative manner to inhibit insulin signaling .", "entity": [{"entity": "PH domain", "entity_type": "GENE", "pos": [34, 43]}, {"entity": "IRS protein", "entity_type": "GENE", "pos": [50, 61]}, {"entity": "insulin", "entity_type": "GENE", "pos": [116, 123]}], "task": "NER"}
{"text": "Is exposure to a patient with Crohn ' s disease an environmental factor for developing the disease .", "entity": [], "task": "NER"}
{"text": "These findings suggest that low - power laser irradiation can be used for promotion of vascularization and take of tissue transplants .", "entity": [], "task": "NER"}
{"text": "In experiment 1 , subjects were required to discriminate male from female faces and no hemispheric asymmetries were found .", "entity": [], "task": "NER"}
{"text": "For the albino , both the ST1 and ST2 spatial responses peak at around 0 . 3 cycles deg - 1 , and both curves are displaced considerably to the low spatial frequency side of the normal ST2 spatial response .", "entity": [], "task": "NER"}
{"text": "The scores for these three factors , which corresponded to recognizable dimensions of depressive illness , were then correlated with rCBF .", "entity": [], "task": "NER"}
{"text": "The etiology was established in 73 ( 76 . 8 % ) out of 95 cases .", "entity": [], "task": "NER"}
{"text": "Depending on the patient ' s body position telemetrically measured CSF - pressures varied between - 20 cmH2O in erect and 15 cmH2O in supine position .", "entity": [], "task": "NER"}
{"text": "Patients received either sodium cephalothin or placebo intravenously before the procedure and for up to 8 additional doses .", "entity": [], "task": "NER"}
{"text": "These findings suggest that NMDA receptor blockade may ameliorate the dyskinetic complications of long - term levodopa therapy , without diminishing the beneficial effects on parkinsonian signs .", "entity": [{"entity": "NMDA receptor", "entity_type": "GENE", "pos": [28, 41]}], "task": "NER"}
{"text": "Before flecainide , all patients had easily inducible VT that was morphologically identical to their spontaneously occurring arrhythmia .", "entity": [], "task": "NER"}
{"text": "In cells infected with a recombinant vaccinia virus expressing HCV structural proteins ( core , E1 , and E2 ) , DDX3 and core colocalized in distinct spots in the perinuclear region of the cytoplasm .", "entity": [{"entity": "core", "entity_type": "GENE", "pos": [89, 93]}, {"entity": "E1", "entity_type": "GENE", "pos": [96, 98]}, {"entity": "E2", "entity_type": "GENE", "pos": [105, 107]}, {"entity": "DDX3", "entity_type": "GENE", "pos": [112, 116]}, {"entity": "core", "entity_type": "GENE", "pos": [121, 125]}], "task": "NER"}
{"text": "However , PC12 cell clones which expressed p33rsu - 1 at an increased level in a regulatable fashion in response to dexamethasone were isolated .", "entity": [{"entity": "p33rsu - 1", "entity_type": "GENE", "pos": [43, 53]}], "task": "NER"}
{"text": "Differential decay of a polycistronic Escherichia coli transcript is initiated by RNaseE - dependent endonucleolytic processing .", "entity": [{"entity": "RNaseE", "entity_type": "GENE", "pos": [82, 88]}], "task": "NER"}
{"text": "An incorrect response on the previous trial enhanced the accuracy in the current trial only in the left visual field ( LVF ) .", "entity": [], "task": "NER"}
{"text": "The SEC27 gene was cloned , and the sequence predicts a 99 . 4 - kDa protein with 45 % sequence identity to mammalian beta ' - COP .", "entity": [{"entity": "SEC27 gene", "entity_type": "GENE", "pos": [4, 14]}, {"entity": "beta ' - COP", "entity_type": "GENE", "pos": [118, 130]}], "task": "NER"}
{"text": "Column chromatographic determination of polymyxin B sulfate .", "entity": [], "task": "NER"}
{"text": "Subgroup analysis failed to show any benefit for etoposide in patients with monocytic or myelomonocytic disease , or in any other diagnostic subgroup .", "entity": [], "task": "NER"}
{"text": "Monosulfates of 16 - oxygenated ketonic C19 steroids in adult human urine .", "entity": [], "task": "NER"}
{"text": "A case of 2 cancers of the colon", "entity": [], "task": "NER"}
{"text": "Pretoria Pasteurisation is feasible and reliable under a range of conditions .", "entity": [], "task": "NER"}
{"text": "Computer analysis revealed that the human protein P1 sequence corresponding to amino acid residues within the N - terminal RNA binding domain displays high homology ( greater than 54 % identity ; 61 to 94 % similarity ) with two animal virus proteins which possess RNA binding activity ( vaccinia virus E3L ; rotavirus VP2 ) and two proteins of unknown function ( murine TIK ; rotavirus NS34 ) , but which are likely RNA binding proteins .", "entity": [{"entity": "human protein P1 sequence", "entity_type": "GENE", "pos": [36, 61]}, {"entity": "vaccinia virus E3L", "entity_type": "GENE", "pos": [288, 306]}, {"entity": "rotavirus VP2", "entity_type": "GENE", "pos": [309, 322]}, {"entity": "murine TIK", "entity_type": "GENE", "pos": [364, 374]}, {"entity": "rotavirus NS34", "entity_type": "GENE", "pos": [377, 391]}], "task": "NER"}
{"text": "C / EBP delta ( NFIL - 6 beta ) was not detected in complexes utilizing extracts from the IL - 1 nonproducing T cell line .", "entity": [{"entity": "C / EBP delta", "entity_type": "GENE", "pos": [0, 13]}, {"entity": "NFIL - 6 beta", "entity_type": "GENE", "pos": [16, 29]}, {"entity": "IL - 1", "entity_type": "GENE", "pos": [90, 96]}], "task": "NER"}
{"text": "Noise in STM due to atoms moving in the tunneling space .", "entity": [], "task": "NER"}
{"text": "However , mutations of the C - rich element that disrupted a GC box located on the inverse strand eliminated PMA responsiveness and , in gel mobility shift assays , eliminated binding of Sp1 .", "entity": [{"entity": "Sp1", "entity_type": "GENE", "pos": [187, 190]}], "task": "NER"}
{"text": "This is a consensus casein kinase II ( CKII ) site and , using purified wild - type and mutant proteins , we show that it is the main CKII site in the body of the N - terminal complex - forming region .", "entity": [{"entity": "casein kinase II", "entity_type": "GENE", "pos": [20, 36]}, {"entity": "CKII", "entity_type": "GENE", "pos": [39, 43]}, {"entity": "CKII site", "entity_type": "GENE", "pos": [134, 143]}], "task": "NER"}
{"text": "Down - regulation of Id1 mRNA correlated with mitogenesis and occurred when quiescent cells were treated with growth factors that activate G protein - coupled receptors and receptor protein tyrosine kinases but not with a non - mitogenic cAMP analog .", "entity": [{"entity": "Id1 mRNA", "entity_type": "GENE", "pos": [21, 29]}, {"entity": "G protein - coupled receptors", "entity_type": "GENE", "pos": [139, 168]}, {"entity": "receptor protein tyrosine kinases", "entity_type": "GENE", "pos": [173, 206]}], "task": "NER"}
{"text": "To study adaptive processes following spinal cord injury , unstructured audiotaped interviews were conducted on an almost daily basis with a 30 - year - old divorced male during the first 3 months of his initial comprehensive inpatient rehabilitation .", "entity": [], "task": "NER"}
{"text": "Cloning and characterization of the 5 ' flanking region of human ATP - citrate lyase gene .", "entity": [{"entity": "human ATP - citrate lyase gene", "entity_type": "GENE", "pos": [59, 89]}], "task": "NER"}
{"text": "The broad range protein tyrosine kinase inhibitor genistein and the phosphatidylinositol 3 - kinase inhibitors wortmannin and LY 294002 ( 2 - ( 4 - morpholinyl ) - 8 - phenyl - 4H - 1 - benzopyran - 4 - one ) also blocked adenosine A3 receptor stimulation of p42 / p44 MAPK .", "entity": [{"entity": "protein tyrosine kinase", "entity_type": "GENE", "pos": [16, 39]}, {"entity": "phosphatidylinositol 3 - kinase", "entity_type": "GENE", "pos": [68, 99]}, {"entity": "adenosine A3 receptor", "entity_type": "GENE", "pos": [222, 243]}, {"entity": "p42", "entity_type": "GENE", "pos": [259, 262]}, {"entity": "p44", "entity_type": "GENE", "pos": [265, 268]}], "task": "NER"}
{"text": "Defective concanavalin A - induced suppression in bancroftian filariasis .", "entity": [{"entity": "concanavalin A", "entity_type": "GENE", "pos": [10, 24]}], "task": "NER"}
{"text": "Rising antibody titres to the astrovirus particles were demonstrated in one child , and IgM was also demonstrated in this patient ' s serum .", "entity": [{"entity": "IgM", "entity_type": "GENE", "pos": [88, 91]}], "task": "NER"}
{"text": "Demonstration of changes in fetal liver erythropoiesis using echo - planar magnetic resonance imaging .", "entity": [], "task": "NER"}
{"text": "Conversely the rate of bioavailability was significantly different , because from the Reference patch the release rate is fast in the first 24 h , leading to an E2 peak at 8 h and to a Cmax in average at 23 h .", "entity": [], "task": "NER"}
{"text": "Effects of dexamethasone on the development of radiation nephropathy in the rat .", "entity": [], "task": "NER"}
{"text": "Reaction of aromatic / heterocyclic sulfonamides possessing free amino , imino or hydrazino moieties with 7 - chloro - 4 - chloromethylcoumarin afforded a series of N - [ ( 7 - chloro - 4 - coumarinyl ) - methyl ] - derivatives which showed effective inhibition of three carbonic anhydrase ( CA ) isozymes .", "entity": [{"entity": "carbonic anhydrase", "entity_type": "GENE", "pos": [271, 289]}, {"entity": "CA", "entity_type": "GENE", "pos": [292, 294]}], "task": "NER"}
{"text": "The present study also emphasizes the need of establishing dose - response curves to correctly assess the relative contribution of the different regions of steroid hormone receptors in activation of transcription .", "entity": [{"entity": "steroid hormone receptors", "entity_type": "GENE", "pos": [156, 181]}], "task": "NER"}
{"text": "( 1986 ) described optic nerve degenerations in patients with Alzheimer ' s disease and Sadun published a dropout of retinal ganglion cells that range from 30 % to 60 % .", "entity": [], "task": "NER"}
{"text": "In addition , these results suggest that the interactions , and consequently the mechanisms , governing transcriptional activation by CTF are distinct from those mediating DNA replication .", "entity": [{"entity": "CTF", "entity_type": "GENE", "pos": [134, 137]}], "task": "NER"}
{"text": "These proteins , called variant surface glycoproteins ( VSGs ) , are expressed from a specific locus , the VSG gene expression site ( ES ) .", "entity": [{"entity": "variant surface glycoproteins", "entity_type": "GENE", "pos": [24, 53]}, {"entity": "VSGs", "entity_type": "GENE", "pos": [56, 60]}, {"entity": "VSG gene expression site ( ES )", "entity_type": "GENE", "pos": [107, 138]}], "task": "NER"}
{"text": "The temporal changes in the plasma concentration of immunoreactive atrial natriuretic factor ( iANF ) were studied in six conscious dogs with an arteriovenous ( AV ) fistula , a model of chronic high - output heart failure .", "entity": [{"entity": "immunoreactive atrial natriuretic factor", "entity_type": "GENE", "pos": [52, 92]}, {"entity": "iANF", "entity_type": "GENE", "pos": [95, 99]}], "task": "NER"}
{"text": "In situ hybridization of whole - mount mouse embryos with Mex5 antisense RNA provide no evidence for the exclusion of Mex5 during embryonic development .", "entity": [{"entity": "Mex5 antisense RNA", "entity_type": "GENE", "pos": [58, 76]}, {"entity": "Mex5", "entity_type": "GENE", "pos": [118, 122]}], "task": "NER"}
{"text": "Karyo - and cytometric investigations of cortical layer V pyramidal neurons of albino rat after three various fixations", "entity": [], "task": "NER"}
{"text": "The cloning of human apo B - 100 has provided new insights into the structure and physicochemical properties of apo B - 100 and will facilitate studies on the factors modulating apo B - 100 biosynthesis and the expression of the apo B - 100 gene in patients with dyslipoproteinemias .", "entity": [{"entity": "human apo B - 100", "entity_type": "GENE", "pos": [15, 32]}, {"entity": "apo B - 100", "entity_type": "GENE", "pos": [112, 123]}, {"entity": "apo B - 100", "entity_type": "GENE", "pos": [178, 189]}, {"entity": "apo B - 100 gene", "entity_type": "GENE", "pos": [229, 245]}], "task": "NER"}
{"text": "In the green unicellular alga Chlamydomonas eugametos , cellular division is readily synchronized by light / dark cycles .", "entity": [], "task": "NER"}
{"text": "Northern blot analysis linked Plk expression to the proliferative activity of cells and tissues .", "entity": [{"entity": "Plk", "entity_type": "GENE", "pos": [30, 33]}], "task": "NER"}
{"text": "A 1 . 5 - month - old boy with Sandifer ' s syndrome is described .", "entity": [], "task": "NER"}
{"text": "A 40 - fold stimulation of chloramphenicol acetyltransferase activity mediated by four tandem repeats of the SNE could be induced within 2 h ( and up to 250 - fold within 6 h ) after addition of TPA in DNA - transfected U - 937 cells , indicating that the stimulation appeared likely to be a true protein kinase C - mediated signal transduction event rather than a differentiation response .", "entity": [{"entity": "chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [27, 60]}, {"entity": "SNE", "entity_type": "GENE", "pos": [109, 112]}, {"entity": "protein kinase C", "entity_type": "GENE", "pos": [297, 313]}], "task": "NER"}
{"text": "A silica - based , fluoride - free placebo containing NaTPP , and a NaF - containing silica - based USP reference standard toothpaste were used as negative and positive control toothpastes , respectively .", "entity": [], "task": "NER"}
{"text": "Molecular cloning of the alpha - globin transcription factor CP2 .", "entity": [{"entity": "alpha - globin transcription factor", "entity_type": "GENE", "pos": [25, 60]}, {"entity": "CP2", "entity_type": "GENE", "pos": [61, 64]}], "task": "NER"}
{"text": "The present study tries to associate some of the causes of hot ischaemia during the agony of the corpse donor and to evaluate those that may be caused by sympathetic efference during removal .", "entity": [], "task": "NER"}
{"text": "The cost and effectiveness of nurse education - - 1 .", "entity": [], "task": "NER"}
{"text": "Between 1988 and 1995 , 341 children with acute myeloid leukaemia ( AML ) were treated on the Medical Research Council Acute Myeloid Leukaemia Trial ( MRC AML10 ) .", "entity": [], "task": "NER"}
{"text": "Using the yeast two - hybrid system , we have isolated an 835 amino acid RING finger ( C3HC4 zinc finger ) protein , TIF1 beta ( also named KAP - 1 ) , that specifically interacts with the KRAB domain of the human zinc finger factor KOX1 / ZNF10 .", "entity": [{"entity": "TIF1 beta", "entity_type": "GENE", "pos": [117, 126]}, {"entity": "KAP - 1", "entity_type": "GENE", "pos": [140, 147]}, {"entity": "KRAB domain", "entity_type": "GENE", "pos": [189, 200]}, {"entity": "KOX1", "entity_type": "GENE", "pos": [233, 237]}, {"entity": "ZNF10", "entity_type": "GENE", "pos": [240, 245]}], "task": "NER"}
{"text": "The N - terminal sequences of isoforms beta to epsilon contain a PEST region which could induce rapid intracellular degradation of isoforms beta and delta .", "entity": [], "task": "NER"}
{"text": "Their central projections were indistinguishable from those of control axons in all four trigeminal subnuclei .", "entity": [], "task": "NER"}
{"text": "Typicality is probably a better representation of Alexander , Dunbar and others ' conclusions than specificity , which was always too absolute a term .", "entity": [], "task": "NER"}
{"text": "We then developed a yeast artificial chromosome ( YAC ) contig for this region .", "entity": [], "task": "NER"}
{"text": "In addition to TAK1 , TGF - beta also stimulated JNK activity .", "entity": [{"entity": "TAK1", "entity_type": "GENE", "pos": [15, 19]}, {"entity": "TGF - beta", "entity_type": "GENE", "pos": [22, 32]}, {"entity": "JNK", "entity_type": "GENE", "pos": [49, 52]}], "task": "NER"}
{"text": "The study was carried out according to the BSI ( 1980 ) recommendations for testing restorative materials in vivo .", "entity": [], "task": "NER"}
{"text": "A case report .", "entity": [], "task": "NER"}
{"text": "Sixteen patients on maintenance hemodialysis underwent dialysis with either cuprophane ( n = 8 ) or polymethylmethacrylate ( PMMA ; n = 8 ) membranes for 1 week and then switched to the opposite membrane during the second week .", "entity": [], "task": "NER"}
{"text": "No significant difference in plasma ET levels was found between cardiac and peripheral sampling sites ( pulmonary artery ; 1 . 07 + / - 0 . 28 , right atrium ; 1 . 02 + / - 0 . 28 , peripheral artery ; 1 . 12 + / - 0 . 23 , peripheral vein ; 1 . 14 + / - 0 . 38 fmol / ml : N . S . ) , or among patients with uncomplicated MI , unstable angina ( 1 . 00 + / - 0 . 32 fmol / ml ) , and healthy subjects ( 1 . 01 + / - 0 . 29 fmol / ml ) .", "entity": [{"entity": "ET", "entity_type": "GENE", "pos": [36, 38]}], "task": "NER"}
{"text": "Oxalates and the digestive tract", "entity": [], "task": "NER"}
{"text": "Analysis of the MCV - 1 RPO1 revealed high amino acid homologies to the corresponding polypeptides of vaccinia and variola virus .", "entity": [{"entity": "MCV - 1 RPO1", "entity_type": "GENE", "pos": [16, 28]}], "task": "NER"}
{"text": "This interaction is functional as it leads to retargeting of NF - kappa B p50 from the nucleus to the cytoplasm .", "entity": [{"entity": "NF - kappa B", "entity_type": "GENE", "pos": [61, 73]}, {"entity": "p50", "entity_type": "GENE", "pos": [74, 77]}], "task": "NER"}
{"text": "Point mutations of Stat3 within the interacting domains blocked both physical interaction of Stat3 with c - Jun and their cooperation in IL - 6 - induced transcription directed by the alpha ( 2 ) - macroglobulin enhancer .", "entity": [{"entity": "Stat3", "entity_type": "GENE", "pos": [19, 24]}, {"entity": "Stat3", "entity_type": "GENE", "pos": [93, 98]}, {"entity": "c - Jun", "entity_type": "GENE", "pos": [104, 111]}, {"entity": "IL - 6", "entity_type": "GENE", "pos": [137, 143]}, {"entity": "alpha ( 2 ) - macroglobulin enhancer", "entity_type": "GENE", "pos": [184, 220]}], "task": "NER"}
{"text": "Identification of masked toxins in the exotoxin complex of Staphylococcus pyogenes und Cl . perfringens ; significance of their existence for clarifying of the masking mechanism", "entity": [], "task": "NER"}
{"text": "Correlation coefficients between SF thickness and NIR optical density readings at 940 nm ( OD1 ) and 950 nm ( OD2 ) wavelengths ranged from r = - 0 . 30 ( subscapula ) to r = - 0 . 67 ( biceps ) for OD1 and r = - 0 . 39 ( axilla ) to r = - 0 . 68 ( biceps ) for OD2 .", "entity": [], "task": "NER"}
{"text": "Transfer of health care to natives holds much promise , lecturers say .", "entity": [], "task": "NER"}
{"text": "In the second group , which consisted of babies of 33 to 36 weeks of gestational age , haptoglobin was detected in 6 infants , with levels less than 25 mg / dl in 3 .", "entity": [{"entity": "haptoglobin", "entity_type": "GENE", "pos": [87, 98]}], "task": "NER"}
{"text": "The clinical picture , the light and electron microscopic appearance , and the histochemical findings are described in six cases of fibroma of tendon sheath .", "entity": [], "task": "NER"}
{"text": "We hypothesize that the ability of these acidic activators to specifically interact with multiple components of the transcription initiation complex likely underlies the dramatic functional synergy exhibited by this class of activation domains in vivo .", "entity": [], "task": "NER"}
{"text": "High and pathological PAI - 1 levels before and after the VO test were consistent with a defective fibrinolytic potential due to the inhibitory effect of PAI - 1 on plasminogen activation .", "entity": [{"entity": "PAI - 1", "entity_type": "GENE", "pos": [22, 29]}, {"entity": "PAI - 1", "entity_type": "GENE", "pos": [154, 161]}, {"entity": "plasminogen", "entity_type": "GENE", "pos": [165, 176]}], "task": "NER"}
{"text": "S . aureus leakage into the totally submerged test specimens was detected in 1 of 5 samples incubated for 4 weeks , while no leakage was detected in specimens incubated for 3 , 5 , 6 , 7 , and 8 weeks .", "entity": [], "task": "NER"}
{"text": "MAPKK kinase / MEKK phosphorylates and activates its downstream protein kinase , MAPK kinase / MEK , which in turn activates MAPK .", "entity": [{"entity": "MAPKK kinase", "entity_type": "GENE", "pos": [0, 12]}, {"entity": "MEKK", "entity_type": "GENE", "pos": [15, 19]}, {"entity": "MAPK kinase", "entity_type": "GENE", "pos": [81, 92]}, {"entity": "MEK", "entity_type": "GENE", "pos": [95, 98]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [125, 129]}], "task": "NER"}
{"text": "The Prompt and Praise condition was superior to the other two conditions in encouraging participation in low - interest recreational activities .", "entity": [], "task": "NER"}
{"text": "The author describes the technique in detail and presents the findings for 25 patients ( 10 men and 15 women ) examined for suspected ileostomy dysfunction , recurrent Crohn ' s disease or ileal obstruction remote from the stoma .", "entity": [], "task": "NER"}
{"text": "Biochemical studies have identified a cellular non - P element - encoded DNA binding protein , termed the inverted repeat binding protein ( IRBP ) , that specifically interacts with the outer half of the 31 - bp terminal inverted repeats .", "entity": [{"entity": "non - P element - encoded DNA binding protein", "entity_type": "GENE", "pos": [47, 92]}, {"entity": "inverted repeat binding protein", "entity_type": "GENE", "pos": [106, 137]}, {"entity": "IRBP", "entity_type": "GENE", "pos": [140, 144]}], "task": "NER"}
{"text": "These findings suggest that eIF5 - eIF2beta interaction plays an essential role in eIF5 function in eukaryotic cells .", "entity": [{"entity": "eIF5", "entity_type": "GENE", "pos": [28, 32]}, {"entity": "eIF2beta", "entity_type": "GENE", "pos": [35, 43]}, {"entity": "eIF5", "entity_type": "GENE", "pos": [83, 87]}], "task": "NER"}
{"text": "The delayed activation of the prostaglandin G / H synthase - 2 promoter in bovine granulosa cells is associated with down - regulation of truncated upstream stimulatory factor - 2 .", "entity": [{"entity": "prostaglandin G / H synthase - 2", "entity_type": "GENE", "pos": [30, 62]}, {"entity": "upstream stimulatory factor - 2", "entity_type": "GENE", "pos": [148, 179]}], "task": "NER"}
{"text": "Nb2 - 11C cells expressed three PNR - related mRNA transcripts of 2 . 5 , 3 . 0 and > 10 kb .", "entity": [{"entity": "PNR - related mRNA transcripts", "entity_type": "GENE", "pos": [32, 62]}], "task": "NER"}
{"text": "E1A + cHa - ras transformed rat embryo fibroblast cells are characterized by high and constitutive DNA binding activities of AP - 1 dimers with significantly altered composition .", "entity": [{"entity": "E1A", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "cHa - ras", "entity_type": "GENE", "pos": [6, 15]}, {"entity": "AP - 1 dimers", "entity_type": "GENE", "pos": [125, 138]}], "task": "NER"}
{"text": "In the present study we have used Southern blot analysis to demonstrate that TSG6 is a single - copy gene in the human and murine species .", "entity": [{"entity": "TSG6", "entity_type": "GENE", "pos": [77, 81]}], "task": "NER"}
{"text": "CONCLUSIONS : Latanoprost administered once daily was significantly more effective in reducing IOP compared with unoprostone administered twice daily in patients with POAG and OH .", "entity": [], "task": "NER"}
{"text": "Activation of HIV gene expression by UV must therefore involve additional cellular processes , such as those triggered by DNA damage , for generation of a full gene expression response .", "entity": [], "task": "NER"}
{"text": "One promoter , p53P1 , is located 100 - 250 bp upstream of the 218 - bp noncoding first exon ; a second , stronger promoter , p53P2 , maps within the first intron .", "entity": [{"entity": "p53P1", "entity_type": "GENE", "pos": [15, 20]}, {"entity": "p53P2", "entity_type": "GENE", "pos": [126, 131]}], "task": "NER"}
{"text": "Hydropathy analysis of deduced A4 amino acid sequence revealed four putative membrane - spanning alpha - helices .", "entity": [], "task": "NER"}
{"text": "This study includes 200 patients treated from 1964 to 1978 , with an age range from 15 to 102 years , who required 329 generators .", "entity": [], "task": "NER"}
{"text": "There is little similarity among the sequences upstream from the CAP site of the Spec2 genes except the TATA consensus sequence and a repeating trinucleotide , AAC .", "entity": [{"entity": "Spec2 genes", "entity_type": "GENE", "pos": [81, 92]}], "task": "NER"}
{"text": "Radiological imaging such as UGI series and CT scan was useful to arrive at an accurate diagnosis .", "entity": [], "task": "NER"}
{"text": "A case of acquired immune deficiency syndrome before 1980 .", "entity": [], "task": "NER"}
{"text": "In the promoters of many immediate early genes , including c - fos , CArG DNA regulatory elements mediate basal constituitive expression and rapid and transient serum induction .", "entity": [{"entity": "immediate early genes", "entity_type": "GENE", "pos": [25, 46]}, {"entity": "c - fos", "entity_type": "GENE", "pos": [59, 66]}], "task": "NER"}
{"text": "We propose that optimal transcription of the gD gene depends on the interaction of ICP4 with multiple binding sites across the gene and cellular factors that recognize specific sequence elements in the promoter .", "entity": [{"entity": "gD gene", "entity_type": "GENE", "pos": [45, 52]}, {"entity": "ICP4", "entity_type": "GENE", "pos": [83, 87]}], "task": "NER"}
{"text": "Strains lacking a functional RPL16A gene grow as rapidly as wild type , whereas those containing a null allele of RPL16B grow more slowly than wild type .", "entity": [{"entity": "functional RPL16A gene", "entity_type": "GENE", "pos": [18, 40]}, {"entity": "RPL16B", "entity_type": "GENE", "pos": [114, 120]}], "task": "NER"}
{"text": "Maduromycosis in Italy", "entity": [], "task": "NER"}
{"text": "Cetn1 possesses the sequence features of an expressed retroposon : the gene lacks introns , the open reading frame is not interrupted by stop codons , and the coding region is flanked by a pair of direct repeats .", "entity": [{"entity": "Cetn1", "entity_type": "GENE", "pos": [0, 5]}], "task": "NER"}
{"text": "Substitutions of Asp11 led to dominant lethality .", "entity": [], "task": "NER"}
{"text": "The Sty1 kinase is stimulated by a variety of different stress conditions including osmotic and oxidative stress and heat shock .", "entity": [{"entity": "Sty1 kinase", "entity_type": "GENE", "pos": [4, 15]}], "task": "NER"}
{"text": "Acute toxicity tests were conducted to measure the response of first instar Toxorhynchites splendens to commonly used mosquito adulticides : malathion , naled and resmethrin .", "entity": [], "task": "NER"}
{"text": "We prospectively studied serum prolactin ( PRL ) elevation after different types of documented seizures in 17 patients .", "entity": [{"entity": "serum prolactin", "entity_type": "GENE", "pos": [25, 40]}, {"entity": "PRL", "entity_type": "GENE", "pos": [43, 46]}], "task": "NER"}
{"text": "To further identify the residues responsible for the activity , we isolated the mutant viruses that were not neutralized with the soluble form of MHV receptor proteins , since such mutants were expected to have mutations in amino acids responsible for receptor - binding activity .", "entity": [{"entity": "MHV receptor proteins", "entity_type": "GENE", "pos": [146, 167]}], "task": "NER"}
{"text": "When lipid X was combined with ticarcillin , survival differences were both significant and prolonged .", "entity": [], "task": "NER"}
{"text": "Furthermore , the secondary stress responses were more pronounced and the ability to recover from them seemed to be impaired in exposed fish as compared to unexposed fish .", "entity": [], "task": "NER"}
{"text": "Focal glomerulosclerosis - like disease with nephrotic syndrome in a horse .", "entity": [], "task": "NER"}
{"text": "In addition , both activated Ral - GDS - like factor and Raf stimulate cyclin D ( 1 ) transcription and E2F activity and act in synergy with PI 3 - kinase .", "entity": [{"entity": "Ral - GDS - like", "entity_type": "GENE", "pos": [29, 45]}, {"entity": "Raf", "entity_type": "GENE", "pos": [57, 60]}, {"entity": "cyclin D ( 1 )", "entity_type": "GENE", "pos": [71, 85]}, {"entity": "E2F", "entity_type": "GENE", "pos": [104, 107]}, {"entity": "PI 3 - kinase", "entity_type": "GENE", "pos": [141, 154]}], "task": "NER"}
{"text": "Treatment with polyinosinic - polycytidylic acid to induce expression of Cre resulted in complete disruption of the Arnt gene and loss of ARNT messenger RNA ( mRNA ) expression in liver .", "entity": [{"entity": "Cre", "entity_type": "GENE", "pos": [73, 76]}, {"entity": "Arnt gene", "entity_type": "GENE", "pos": [116, 125]}, {"entity": "ARNT messenger RNA", "entity_type": "GENE", "pos": [138, 156]}], "task": "NER"}
{"text": "Twelve patients of leprosy with arthritis and 161 patients without arthritis were studied for immunological parameters like immunoglobulins ( IgG , IgM , IgA ) , C - reactive proteins and rheumatoid factor .", "entity": [{"entity": "immunoglobulins", "entity_type": "GENE", "pos": [124, 139]}, {"entity": "IgG", "entity_type": "GENE", "pos": [142, 145]}, {"entity": "IgM", "entity_type": "GENE", "pos": [148, 151]}, {"entity": "IgA", "entity_type": "GENE", "pos": [154, 157]}, {"entity": "C - reactive proteins", "entity_type": "GENE", "pos": [162, 183]}, {"entity": "rheumatoid factor", "entity_type": "GENE", "pos": [188, 205]}], "task": "NER"}
{"text": "The biological functions of rat surfactant protein A ( SP - A ) , an oligomer composed of 18 polypeptide subunits derived from a single gene , are dependent on intact disulfide bonds .", "entity": [{"entity": "surfactant protein A", "entity_type": "GENE", "pos": [32, 52]}, {"entity": "SP - A", "entity_type": "GENE", "pos": [55, 61]}], "task": "NER"}
{"text": "DIC and low grade fibrinolysis may account for the coagulation abnormalities of the syndrome .", "entity": [], "task": "NER"}
{"text": "All depressive groups showed improved error measures post - treatment .", "entity": [], "task": "NER"}
{"text": "Plasmid subclones of the hr1a - containing AcMNPV HindIII - N fragment were examined for their ability to replicate in virus - infected ( Spodoptera frugiperda ) Sf9 cells , and to stimulate transcription when linked in cis with a 39K gene promoter - beta - glucuronidase fusion and cotransfected into cells along with a plasmid ( ple - 1 ) containing the gene encoding the trans - acting factor IE - 1 .", "entity": [{"entity": "hr1a", "entity_type": "GENE", "pos": [25, 29]}, {"entity": "HindIII", "entity_type": "GENE", "pos": [50, 57]}, {"entity": "39K gene promoter - beta - glucuronidase fusion", "entity_type": "GENE", "pos": [231, 278]}, {"entity": "IE - 1", "entity_type": "GENE", "pos": [396, 402]}], "task": "NER"}
{"text": "This new receptor , TOR ( thymus orphan receptor ) , is most closely related in both its DNA - binding domain and ligand - binding domain , 90 % and 53 % , respectively , to ROR alpha / RZR alpha and clusters with these two receptors and RZR beta in a phylogenetic tree , when both the DNA - binding domain and the ligand - binding domain sequences of nuclear receptors are compared .", "entity": [{"entity": "TOR", "entity_type": "GENE", "pos": [20, 23]}, {"entity": "thymus orphan receptor", "entity_type": "GENE", "pos": [26, 48]}, {"entity": "ROR alpha", "entity_type": "GENE", "pos": [174, 183]}, {"entity": "RZR alpha", "entity_type": "GENE", "pos": [186, 195]}, {"entity": "RZR beta", "entity_type": "GENE", "pos": [238, 246]}], "task": "NER"}
{"text": "Immunofluorescence tests for Borrelia burgdorferi serum antibodies had positive results , but G - penicillin treatment was ineffective .", "entity": [{"entity": "Borrelia burgdorferi serum antibodies", "entity_type": "GENE", "pos": [29, 66]}], "task": "NER"}
{"text": "Laser soldering with exogenous fibrinogen is feasible without topical administration of additional clotting agents , significantly improves the bursting strength of primary laser welded anastomoses , and appears to result from urokinase - resistant fibrinogen cross - linking .", "entity": [{"entity": "fibrinogen", "entity_type": "GENE", "pos": [31, 41]}, {"entity": "urokinase", "entity_type": "GENE", "pos": [227, 236]}, {"entity": "fibrinogen", "entity_type": "GENE", "pos": [249, 259]}], "task": "NER"}
{"text": "Raman scattering from VO2 single crystals : A study of the effects of surface oxidation .", "entity": [], "task": "NER"}
{"text": "Left ventricular insufficiency requires two SP / patient , with good results in approximately 81 p . cent .", "entity": [], "task": "NER"}
{"text": "Overexpression of wild type and SeCys / Cys mutant of human thioredoxin reductase in E . coli : the role of selenocysteine in the catalytic activity .", "entity": [{"entity": "human thioredoxin reductase", "entity_type": "GENE", "pos": [54, 81]}], "task": "NER"}
{"text": "50 - fold increase in foreign protein production .", "entity": [], "task": "NER"}
{"text": "A rare tRNA - Arg ( CCU ) that regulates Ty1 element ribosomal frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae .", "entity": [{"entity": "tRNA - Arg ( CCU )", "entity_type": "GENE", "pos": [7, 25]}, {"entity": "Ty1 element", "entity_type": "GENE", "pos": [41, 52]}, {"entity": "Ty1", "entity_type": "GENE", "pos": [94, 97]}], "task": "NER"}
{"text": "In addition , putative binding sites for SH3 and SH2 domains are present in the amino - terminal half of the molecule .", "entity": [{"entity": "SH3", "entity_type": "GENE", "pos": [41, 44]}, {"entity": "SH2 domains", "entity_type": "GENE", "pos": [49, 60]}], "task": "NER"}
{"text": "The technique used by this system involves a transient , externally applied increase in resistance to breathing .", "entity": [], "task": "NER"}
{"text": "Vorozole ( Rivizor ) is a potent and stereospecific inhibitor of aromatase having shown promising endocrine effects in phase I studies .", "entity": [{"entity": "aromatase", "entity_type": "GENE", "pos": [65, 74]}], "task": "NER"}
{"text": "Mapping the 5 ' and 3 ' termini of TED RNAs indicated that the LTRs have a retroviral U3 - R - U5 structural organization that is capable of directing the synthesis of transcripts that represent potential substrates for reverse transcription and intermediates in transposition .", "entity": [{"entity": "TED RNAs", "entity_type": "GENE", "pos": [35, 43]}], "task": "NER"}
{"text": "A Meis1 cDNA clone that encoded a novel member of the homeobox gene family was identified .", "entity": [{"entity": "Meis1 cDNA", "entity_type": "GENE", "pos": [2, 12]}, {"entity": "homeobox gene family", "entity_type": "GENE", "pos": [54, 74]}], "task": "NER"}
{"text": "Cellular lysates were analyzed for luciferase and beta - galactosidase activities .", "entity": [{"entity": "luciferase", "entity_type": "GENE", "pos": [35, 45]}, {"entity": "beta - galactosidase", "entity_type": "GENE", "pos": [50, 70]}], "task": "NER"}
{"text": "The protein contains a SHAQKYF amino acid signature motif in the second myb - like repeat , which is highly conserved in a number of recently identified plant myb - related genes , thus defining a new class of plant DNA - binding proteins .", "entity": [{"entity": "myb - like repeat", "entity_type": "GENE", "pos": [72, 89]}, {"entity": "plant myb - related genes", "entity_type": "GENE", "pos": [153, 178]}], "task": "NER"}
{"text": "However , sphincter length decreased with age from 24 . 3 to 14 . 8 mm . , maximal urethral pressure from 88 . 7 to 55 cm . water and maximal urethral pressure during voluntary contraction from 221 . 4 to 166 . 3 cm . water .", "entity": [], "task": "NER"}
{"text": "The DF3 / MUC1 gene encodes a high molecular weight mucin - like glycoprotein which is overexpressed at the transcriptional level in the majority of human breast cancers .", "entity": [{"entity": "DF3", "entity_type": "GENE", "pos": [4, 7]}, {"entity": "MUC1", "entity_type": "GENE", "pos": [10, 14]}, {"entity": "high molecular weight mucin - like glycoprotein", "entity_type": "GENE", "pos": [30, 77]}], "task": "NER"}
{"text": "A cephalothoracophagus disymmetros buffalo calf .", "entity": [], "task": "NER"}
{"text": "In 32 of them the results of an exercise performance test based on heart rate response to submaximal exercise ( VO2 , 170 [ bpm ] ) was compared with another index of physical performance capacity , which is independent from heart rate : the ventilatory threshold .", "entity": [], "task": "NER"}
{"text": "Treatment with KP - 45 preparation usually resulted in partial regression of tumor growth , accompanied by improvement of the clinical state of these patients , as well as reappearance of normal values of blood picture and biochemical parameters .", "entity": [], "task": "NER"}
{"text": "Electromobility shift analysis using oligonucleotides encompassing the proximal , distal , and BED / AP - 1 - binding regions failed to demonstrate selective transactivation after CD2 signaling of LPMC .", "entity": [{"entity": "AP - 1", "entity_type": "GENE", "pos": [101, 107]}, {"entity": "CD2", "entity_type": "GENE", "pos": [180, 183]}], "task": "NER"}
{"text": "Four families of homing endonucleases have been identified , including the LAGLIDADG , the His - Cys box , the GIY - YIG and the H - N - H endonucleases .", "entity": [{"entity": "homing endonucleases", "entity_type": "GENE", "pos": [17, 37]}, {"entity": "LAGLIDADG", "entity_type": "GENE", "pos": [75, 84]}, {"entity": "His - Cys box", "entity_type": "GENE", "pos": [91, 104]}, {"entity": "GIY - YIG", "entity_type": "GENE", "pos": [111, 120]}, {"entity": "H - N - H endonucleases", "entity_type": "GENE", "pos": [129, 152]}], "task": "NER"}
{"text": "The use of aluminum hydroxide was associated with an increase in fecal fluoride excretion and a decrease in net absorption of fluoride regardless of the intake fluoride , calcium , phosphorus , or magnesium .", "entity": [], "task": "NER"}
{"text": "Administration of SnCl2 and ZnSO4 ( group V ) resulted in a decrease of ALA - D activity and in an increase in CP - U .", "entity": [{"entity": "ALA - D", "entity_type": "GENE", "pos": [72, 79]}], "task": "NER"}
{"text": "Coexistence of Turner ' s syndrome and schizophrenia", "entity": [], "task": "NER"}
{"text": "A selectable marker for transformation was constructed by transcriptional fusion of a Ustilago maydis heat shock gene promoter with the hygromycin B phosphotransferase gene of Escherichia coli .", "entity": [{"entity": "Ustilago maydis heat shock gene promoter", "entity_type": "GENE", "pos": [86, 126]}, {"entity": "hygromycin B phosphotransferase gene of Escherichia coli", "entity_type": "GENE", "pos": [136, 192]}], "task": "NER"}
{"text": "Moreover , FACT specifically interacts with nucleosomes and histone H2A / H2B dimers , indicating that it may work by promoting nucleosome disassembly upon transcription .", "entity": [{"entity": "FACT", "entity_type": "GENE", "pos": [11, 15]}, {"entity": "H2A", "entity_type": "GENE", "pos": [68, 71]}, {"entity": "H2B", "entity_type": "GENE", "pos": [74, 77]}], "task": "NER"}
{"text": "All exon / intron splice junctions follow the GT / AG rule .", "entity": [], "task": "NER"}
{"text": "Acetoacetate decarboxylase ( ADC ) ( EC4 . 1 . 1 . 4 ) of Clostridium acetobutylicum DSM 792 was purified to homogeneity , and its first 25 N - terminal amino acids were determined .", "entity": [{"entity": "Acetoacetate decarboxylase", "entity_type": "GENE", "pos": [0, 26]}, {"entity": "ADC", "entity_type": "GENE", "pos": [29, 32]}, {"entity": "EC4 . 1 . 1 . 4", "entity_type": "GENE", "pos": [37, 52]}], "task": "NER"}
{"text": "These studies suggest that tandem alpha - helices located near the C - terminus of PC - TP facilitate membrane binding and extraction of phosphatidylcholines .", "entity": [{"entity": "PC - TP", "entity_type": "GENE", "pos": [83, 90]}], "task": "NER"}
{"text": "In this study , we investigated the mechanism by which Tax activates gene expression in conjunction with members of the ATF / CREB family .", "entity": [{"entity": "Tax", "entity_type": "GENE", "pos": [55, 58]}, {"entity": "ATF", "entity_type": "GENE", "pos": [120, 123]}, {"entity": "CREB", "entity_type": "GENE", "pos": [126, 130]}], "task": "NER"}
{"text": "Repression of the herpes simplex virus 1 alpha 4 gene by its gene product ( ICP4 ) within the context of the viral genome is conditioned by the distance and stereoaxial alignment of the ICP4 DNA binding site relative to the TATA box .", "entity": [{"entity": "herpes simplex virus 1 alpha 4 gene", "entity_type": "GENE", "pos": [18, 53]}, {"entity": "ICP4", "entity_type": "GENE", "pos": [76, 80]}, {"entity": "ICP4 DNA binding site", "entity_type": "GENE", "pos": [186, 207]}], "task": "NER"}
{"text": "We studied 18 dogs , anaesthetised and spontaneously breathing both room air and after the inhalation of a gas mixture containing 10 % CO2 , 20 . 9 % O2 , and 69 . 1 % N2 , to determine the role of histamine , serotonin , and acidaemia in pulmonary hypertension produced by hypercapnia .", "entity": [], "task": "NER"}
{"text": "Disaster medicine", "entity": [], "task": "NER"}
{"text": "In both liver and pancreatic islet , glucokinase is subject to inhibition by a regulatory protein ( GCKR ) .", "entity": [{"entity": "glucokinase", "entity_type": "GENE", "pos": [37, 48]}, {"entity": "GCKR", "entity_type": "GENE", "pos": [100, 104]}], "task": "NER"}
{"text": "At promoters that initiate with + 1 GGG , T7 RNAP synthesizes a ladder of poly ( G ) products as a result of slippage of the transcript on the three C residues in the template strand from + 1 to + 3 .", "entity": [{"entity": "T7 RNAP", "entity_type": "GENE", "pos": [42, 49]}], "task": "NER"}
{"text": "Transcription analysis of the EcoRI D region of the baculovirus Autographa californica nuclear polyhedrosis virus identifies an early 4 - kilobase RNA encoding the essential p143 gene .", "entity": [{"entity": "EcoRI D region", "entity_type": "GENE", "pos": [30, 44]}, {"entity": "p143 gene", "entity_type": "GENE", "pos": [174, 183]}], "task": "NER"}
{"text": "Vectorcardiography in coronary patients with the electrocardiographic RS segment in the V1 lead", "entity": [], "task": "NER"}
{"text": "In this second clinical paper , the genetic features of the case of microphthalmia in sheep reported by Wagenaar is discussed in greater detail .", "entity": [], "task": "NER"}
{"text": "Both the arterial and venous thrombi were clearly discernible at 2 to 8 h after injection of 99Tcm - SZ - 51 .", "entity": [], "task": "NER"}
{"text": "First aid .", "entity": [], "task": "NER"}
{"text": "However , the blend of Metanil yellow and Orange II ( 1 : 1 ) resulted in the D1 50 . value of 288 min .", "entity": [], "task": "NER"}
{"text": "A novel protein kinase C ( PKC ) - interacting protein was identified by the yeast two - hybrid screening using the regulatory domain of PKC beta I as a bait .", "entity": [{"entity": "protein kinase C", "entity_type": "GENE", "pos": [8, 24]}, {"entity": "PKC", "entity_type": "GENE", "pos": [27, 30]}, {"entity": "PKC beta I", "entity_type": "GENE", "pos": [137, 147]}], "task": "NER"}
{"text": "In this study , we show that the activating effect of this mutation is not the result of creating an exonic splicing enhancer ( ESE ) or disrupting a putative secondary structure .", "entity": [], "task": "NER"}
{"text": "The architecture of the hRap1 Myb domain is very close to that of each of the Myb domains from TRF1 , scRap1p and c - Myb .", "entity": [{"entity": "hRap1", "entity_type": "GENE", "pos": [24, 29]}, {"entity": "Myb domain", "entity_type": "GENE", "pos": [30, 40]}, {"entity": "Myb domains", "entity_type": "GENE", "pos": [78, 89]}, {"entity": "TRF1", "entity_type": "GENE", "pos": [95, 99]}, {"entity": "scRap1p", "entity_type": "GENE", "pos": [102, 109]}, {"entity": "c - Myb", "entity_type": "GENE", "pos": [114, 121]}], "task": "NER"}
{"text": "This was tragically highlighted by the death of a 17 year old dental nurse after taking a single 1 g tablet of sodium nitrite .", "entity": [], "task": "NER"}
{"text": "However , this posttranslational modification of the gar2 protein does not appear to be essential for normal production of 18S rRNA .", "entity": [{"entity": "gar2 protein", "entity_type": "GENE", "pos": [53, 65]}, {"entity": "18S rRNA", "entity_type": "GENE", "pos": [123, 131]}], "task": "NER"}
{"text": "The BRSV L gene is 6573 nt in length and the derived polypeptide has 2162 aa .", "entity": [{"entity": "BRSV L gene", "entity_type": "GENE", "pos": [4, 15]}], "task": "NER"}
{"text": "BRAP2 also shares significant homology with a hypothetical protein from yeast Saccharomyces cerevisiae , especially in the zinc finger region .", "entity": [{"entity": "BRAP2", "entity_type": "GENE", "pos": [0, 5]}], "task": "NER"}
{"text": "We have isolated and determined the complete nucleotide sequence of another operon , cpeCD , that encodes the linker proteins associated with phycoerythrin hexamers in the phycobilisome .", "entity": [{"entity": "cpeCD", "entity_type": "GENE", "pos": [85, 90]}, {"entity": "phycoerythrin hexamers", "entity_type": "GENE", "pos": [142, 164]}, {"entity": "phycobilisome", "entity_type": "GENE", "pos": [172, 185]}], "task": "NER"}
{"text": "Here , we describe the results of a detailed study aimed at identifying the gene or genes responsible for the rapid growth - arrest response obtained with human chromosome - 9 .", "entity": [], "task": "NER"}
{"text": "A novel Cdc42Hs mutant induces cellular transformation .", "entity": [{"entity": "Cdc42Hs mutant", "entity_type": "GENE", "pos": [8, 22]}], "task": "NER"}
{"text": "We identified Tyr ( 112 ) and Leu ( 175 ) within the RNA - binding domain of the U1 70K protein to be cross - linked to G ( 28 ) and U ( 30 ) in stem - loop I , respectively .", "entity": [{"entity": "U1 70K protein", "entity_type": "GENE", "pos": [81, 95]}], "task": "NER"}
{"text": "In general , the scallop extract potentiated phototactic suppression .", "entity": [], "task": "NER"}
{"text": "Magnetic field influence on central nervous system function .", "entity": [], "task": "NER"}
{"text": "Only Staphylococcus xylosus SX63 was detected as a strain with high adherence activity .", "entity": [], "task": "NER"}
{"text": "Macrophages : modulators of immunity .", "entity": [], "task": "NER"}
{"text": "METHODS : The Die Deutsche Diabetes Dialyse Studie is a prospective randomized placebo - controlled trial that tests the hypothesis that atorvastatin , a hydroxymethyl - glutaryl coenzyme A reductase inhibitor , decreases the rate of cardiovascular mortality and of nonfatal myocardial infarction in patients with type 2 diabetes who have been on hemodialysis treatment for no more than two years .", "entity": [{"entity": "hydroxymethyl - glutaryl coenzyme A reductase", "entity_type": "GENE", "pos": [154, 199]}], "task": "NER"}
{"text": "An OD 650 greater than 0 . 15 appears to be a rapid , reliable indicator of fetal lung maturity .", "entity": [], "task": "NER"}
{"text": "This high dose 5 - FU + Act - D protocol was effective for drug resistant cases with MEA protocol .", "entity": [], "task": "NER"}
{"text": "Therefore , it appears that GCN2 protein kinase function is stimulated posttranslationally in amino acid - starved cells .", "entity": [{"entity": "GCN2 protein kinase", "entity_type": "GENE", "pos": [28, 47]}], "task": "NER"}
{"text": "CSEn stimulated transcription of a variety of promoters , including the hCS , human growth hormone , thymidine kinase , and Rous sarcoma virus promoters , in human choriocarcinoma cell lines ( BeWo and JEG - 3 ) but not HeLa cells or rat somatolactotrophes ( GC ) .", "entity": [{"entity": "CSEn", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "hCS", "entity_type": "GENE", "pos": [72, 75]}, {"entity": "human growth hormone", "entity_type": "GENE", "pos": [78, 98]}, {"entity": "thymidine kinase", "entity_type": "GENE", "pos": [101, 117]}, {"entity": "Rous sarcoma virus promoters", "entity_type": "GENE", "pos": [124, 152]}], "task": "NER"}
{"text": "HIV - 2 in Spain .", "entity": [], "task": "NER"}
{"text": "Reversal of mefloquine resistance in rodent Plasmodium .", "entity": [], "task": "NER"}
{"text": "Airborne rabies encephalitis : demonstration of rabies virus in the human central nervous system .", "entity": [], "task": "NER"}
{"text": "No promoter activity could be detected with various mouse Fli - 1 promoter - CAT constructs containing 600 bp of the 5 ' flanking region , the complete exon 1 , the 5 ' end of intron 1 and / or retroviral LTR sequence .", "entity": [{"entity": "mouse Fli - 1 promoter", "entity_type": "GENE", "pos": [52, 74]}, {"entity": "CAT", "entity_type": "GENE", "pos": [77, 80]}], "task": "NER"}
{"text": "We now show that the FRAP Ser2035 - - > Ala mutant displays similar binding affinity when compared with the wild - type protein , whereas all other mutations at this site , including mimics of phosphoserine , abolish binding , presumably due to either unfavorable steric interactions or induced conformational changes .", "entity": [{"entity": "FRAP", "entity_type": "GENE", "pos": [21, 25]}], "task": "NER"}
{"text": "These findings suggest that the mechanism of ribosomal frameshifting at the PVM signal is different from the one described by the ' simultaneous slippage ' model in that only the string of four adenosine nucleotides represents the slippery sequence involved in a - 1 P - site slippage .", "entity": [], "task": "NER"}
{"text": "The fru gene has seven exons spanning 15 - kb encoding two transcripts with ORFs of 841 and 695 amino acids .", "entity": [{"entity": "fru gene", "entity_type": "GENE", "pos": [4, 12]}], "task": "NER"}
{"text": "This sequence can interact with at least two proteins in a fibroblast nuclear extract that have binding characteristics of an Ets family protein and a serum response factor - like protein .", "entity": [{"entity": "Ets family protein", "entity_type": "GENE", "pos": [126, 144]}, {"entity": "serum response factor - like protein", "entity_type": "GENE", "pos": [151, 187]}], "task": "NER"}
{"text": "Response properties of single units in the accessory optic system of the dark - reared cat .", "entity": [], "task": "NER"}
{"text": "Effect of tetracycline on the glycogen - producing function of the liver and intestinal microflora in white mice", "entity": [], "task": "NER"}
{"text": "Significantly higher levels of vitamin C and catalase activity were found in vegetarians ( C - 63 . 6 and 86 . 5 mumol / l ; CAT - 1497 and 1313 U / ml for males and females , respectively ) when compared to nonvegetarians ( C - 41 . 3 and 54 . 4 mumol / l ; CAT - 1192 and 1086 U / ml ) .", "entity": [{"entity": "catalase", "entity_type": "GENE", "pos": [45, 53]}], "task": "NER"}
{"text": "However , only plasma fibrinogen concentrations showed statistically significant positive associations with IMT in both groups .", "entity": [{"entity": "plasma fibrinogen", "entity_type": "GENE", "pos": [15, 32]}], "task": "NER"}
{"text": "METHODS .", "entity": [], "task": "NER"}
{"text": "Presently , we made chain pair switch , chimeric , and site mutant gamma delta TCRs and transfected them into TCR - mutant Jurkat T cells to examine the effects of changing the TCR gamma junctional region sequences on reactivity to prenyl pyrophosphate Ags .", "entity": [{"entity": "mutant gamma delta TCRs", "entity_type": "GENE", "pos": [60, 83]}, {"entity": "TCR gamma junctional region sequences", "entity_type": "GENE", "pos": [177, 214]}, {"entity": "prenyl pyrophosphate Ags", "entity_type": "GENE", "pos": [232, 256]}], "task": "NER"}
{"text": "The molecular dynamics simulations provide insight into the conformational flexibility of these analogs .", "entity": [], "task": "NER"}
{"text": "Modified Grocott ' s methenamine silver nitrate method for quick staining of Pneumocystis carinii .", "entity": [], "task": "NER"}
{"text": "The control of human aromatase expression is complex in that several promoters drive aromatase expression in a tissue - specific manner .", "entity": [{"entity": "human aromatase", "entity_type": "GENE", "pos": [15, 30]}, {"entity": "aromatase", "entity_type": "GENE", "pos": [85, 94]}], "task": "NER"}
{"text": "Surprisingly , although Mist1 binds to E - boxes in vivo , the Mist1 protein lacks a functional transcription activation domain .", "entity": [{"entity": "Mist1", "entity_type": "GENE", "pos": [24, 29]}, {"entity": "Mist1 protein", "entity_type": "GENE", "pos": [63, 76]}], "task": "NER"}
{"text": "Selective upper abdominal sympathectomy increased basal acid output in rats but was without effect on stimulated acid output , serum gastrin concentration , and gastric mucosal histidine decarboxylase activity .", "entity": [{"entity": "serum gastrin", "entity_type": "GENE", "pos": [127, 140]}, {"entity": "gastric mucosal histidine decarboxylase", "entity_type": "GENE", "pos": [161, 200]}], "task": "NER"}
{"text": "To isolate genes that contain zinc finger motifs , a human brain cDNA library was screened with an oligonucleotide complementary to the conserved \" linker \" sequence between adjacent zinc fingers .", "entity": [], "task": "NER"}
{"text": "Transforming growth factor beta activates the promoter of cyclin - dependent kinase inhibitor p15INK4B through an Sp1 consensus site .", "entity": [{"entity": "Transforming growth factor beta", "entity_type": "GENE", "pos": [0, 31]}, {"entity": "cyclin - dependent kinase", "entity_type": "GENE", "pos": [58, 83]}, {"entity": "p15INK4B", "entity_type": "GENE", "pos": [94, 102]}, {"entity": "Sp1 consensus site", "entity_type": "GENE", "pos": [114, 132]}], "task": "NER"}
{"text": "Thus , in addition to the previously characterized FAS - binding factor 1 interacting with the inositol / choline - responsive - element motif , a second motif common to the promoter regions of both FAS genes could be identified .", "entity": [{"entity": "FAS - binding factor 1", "entity_type": "GENE", "pos": [51, 73]}, {"entity": "FAS genes", "entity_type": "GENE", "pos": [199, 208]}], "task": "NER"}
{"text": "Kluyveromyces lactis , a budding yeast related to Saccharomyces cerevisiae , can grow on a wider variety of substrates and shows less sensitivity to glucose repression than does Saccharomyces cerevisiae .", "entity": [], "task": "NER"}
{"text": "Sociological analysis of the family .", "entity": [], "task": "NER"}
{"text": "Like other known GCD genes , GCD14 and GCD15 are therefore probably required for general translation initiation in addition to their roles in GCN4 - specific translational control .", "entity": [{"entity": "GCD genes", "entity_type": "GENE", "pos": [17, 26]}, {"entity": "GCD14", "entity_type": "GENE", "pos": [29, 34]}, {"entity": "GCD15", "entity_type": "GENE", "pos": [39, 44]}, {"entity": "GCN4", "entity_type": "GENE", "pos": [142, 146]}], "task": "NER"}
{"text": "Sorting information to the chloroplastic inner envelope is contained in an NH2 - proximal part of mature IEP110 ( 110N ) .", "entity": [{"entity": "mature IEP110", "entity_type": "GENE", "pos": [98, 111]}, {"entity": "110N", "entity_type": "GENE", "pos": [114, 118]}], "task": "NER"}
{"text": "Both algorithms have been implemented and applied to data simulated for a scanner with a large axial aperture ( 30 degrees ) , and also to data acquired with the ECAT HR and the ECAT HR + scanners .", "entity": [], "task": "NER"}
{"text": "BACKGROUND : Murine Nramp is a candidate for the macrophage resistance gene Ity / Lsh / Bcg .", "entity": [{"entity": "Murine Nramp", "entity_type": "GENE", "pos": [13, 25]}, {"entity": "Ity", "entity_type": "GENE", "pos": [76, 79]}, {"entity": "Lsh", "entity_type": "GENE", "pos": [82, 85]}, {"entity": "Bcg", "entity_type": "GENE", "pos": [88, 91]}], "task": "NER"}
{"text": "Serum zinc and copper levels and urine copper concentrations in men were significantly lower than in women , while there were no differences in serum or urinary zinc and copper levels with age .", "entity": [], "task": "NER"}
{"text": "Pregnancy was ensued in 4 cases in group I .", "entity": [], "task": "NER"}
{"text": "CONCLUSION : In these patients control of ventricular response rate with either HBA + VVIR pacemaker or atrioventricular modifying drugs + VVI pacemaker will lead to a significant improvement in exercise duration and quality of life .", "entity": [], "task": "NER"}
{"text": "Western immunoblot analysis detected p55gag and its cleavage products p39 and p27 in purified particles derived by expression of gag and gag - pol , respectively .", "entity": [{"entity": "p55gag", "entity_type": "GENE", "pos": [37, 43]}, {"entity": "p39", "entity_type": "GENE", "pos": [70, 73]}, {"entity": "p27", "entity_type": "GENE", "pos": [78, 81]}, {"entity": "gag", "entity_type": "GENE", "pos": [129, 132]}, {"entity": "gag", "entity_type": "GENE", "pos": [137, 140]}, {"entity": "pol", "entity_type": "GENE", "pos": [143, 146]}], "task": "NER"}
{"text": "These three phases of cyclin E association with chromatin may facilitate the diverse activities of cyclin E - - Cdk2 in initiating replication , blocking rereplication , and allowing resetting of origins after mitosis .", "entity": [{"entity": "cyclin E", "entity_type": "GENE", "pos": [22, 30]}, {"entity": "cyclin E", "entity_type": "GENE", "pos": [99, 107]}, {"entity": "Cdk2", "entity_type": "GENE", "pos": [112, 116]}], "task": "NER"}
{"text": "It has been shown that renin secretion is stimulated by endothelin , a recently discovered peptide with strong vasoconstrictive properties and stimulating effects on renin secretion .", "entity": [{"entity": "renin", "entity_type": "GENE", "pos": [23, 28]}, {"entity": "endothelin", "entity_type": "GENE", "pos": [56, 66]}, {"entity": "renin", "entity_type": "GENE", "pos": [166, 171]}], "task": "NER"}
{"text": "A higher percentage of children with cerebral malaria ( 40 per cent ) than with non - cerebral malaria ( 29 per cent ) or controls ( 20 per cent ) also had either serum ferritin < 100 micrograms / l and inflammation or sTfR > 7 . 3 mg / l or both .", "entity": [{"entity": "serum ferritin", "entity_type": "GENE", "pos": [163, 177]}, {"entity": "sTfR", "entity_type": "GENE", "pos": [219, 223]}], "task": "NER"}
{"text": "Patients received BPB using bupivacaine 2 mg kg - 1 with adrenaline 1 in 200 , 000 , either with or without hyaluronidase 3000 iu , in a volume of 0 . 5 ml per 2 . 54 cm of the patient ' s height .", "entity": [{"entity": "hyaluronidase", "entity_type": "GENE", "pos": [108, 121]}], "task": "NER"}
{"text": "The rifampicin resistance of uvsW - repressed replication suggests that it involves either tertiary initiation or some novel mode of initiation .", "entity": [{"entity": "uvsW", "entity_type": "GENE", "pos": [29, 33]}], "task": "NER"}
{"text": "Association between hyperhomocysteinemia and ischemic heart disease in Sri Lankans .", "entity": [], "task": "NER"}
{"text": "These findings suggest that the proteolipids of the vacuolar H + - ATPases were evolved in parallel with the eubacterial proteolipid , from a common ancestral gene that underwent gene duplication .", "entity": [{"entity": "vacuolar H + - ATPases", "entity_type": "GENE", "pos": [52, 74]}], "task": "NER"}
{"text": "Coexpression of c - Rel in combination with ATF - 1 , CREB2 , or ATF - 1 / CREB2 leads to synergistic transactivation of a CD28RE - TRE reporter plasmid in quiescent Jurkat T - cells .", "entity": [{"entity": "c - Rel", "entity_type": "GENE", "pos": [16, 23]}, {"entity": "ATF - 1", "entity_type": "GENE", "pos": [44, 51]}, {"entity": "CREB2", "entity_type": "GENE", "pos": [54, 59]}, {"entity": "ATF - 1", "entity_type": "GENE", "pos": [65, 72]}, {"entity": "CREB2", "entity_type": "GENE", "pos": [75, 80]}, {"entity": "CD28RE - TRE reporter", "entity_type": "GENE", "pos": [123, 144]}], "task": "NER"}
{"text": "Characterization of a cDNA encoding CNN predicts a novel structural protein with three leucine zipper motifs and several coiled - coil domains exhibiting limited homology to the rod portion of myosin .", "entity": [{"entity": "cDNA encoding CNN", "entity_type": "GENE", "pos": [22, 39]}, {"entity": "myosin", "entity_type": "GENE", "pos": [193, 199]}], "task": "NER"}
{"text": "It is suggested that the loss of weight , the decrease in food intake and the increase in brain MOPEG - SO4 induced by cyanamide reflect possible anorectic properties of the drug .", "entity": [], "task": "NER"}
{"text": "The differential diagnosis of mineral oil lipidosis in lymph nodes with reaction to radiopaque oils and Whipple ' s disease is discussed .", "entity": [], "task": "NER"}
{"text": "The serum levels of cortisol and prolactin after nasal instillation of a suspension of vaginal exudate showed lower values than in control conditions ( nasal instillation of saline ) .", "entity": [{"entity": "prolactin", "entity_type": "GENE", "pos": [33, 42]}], "task": "NER"}
{"text": "This enhancer element functioned in a position - and orientation - independent manner both on the Pax - QNR P0 promoter and the heterologous thymidine kinase promoter .", "entity": [{"entity": "Pax - QNR P0 promoter", "entity_type": "GENE", "pos": [98, 119]}, {"entity": "heterologous thymidine kinase promoter", "entity_type": "GENE", "pos": [128, 166]}], "task": "NER"}
{"text": "The data when used to stimulate the collection of the information at antenatal or postnatal visits , nonetheless provide an accurate description of under - 3 mortality trends and differences for the two periods examined - - before 1984 and before 1989 .", "entity": [], "task": "NER"}
{"text": "The BHV - 1 UL24 , UL25 , UL26 and UL26 . 5 transcripts all terminated at a common 3 ' - polyadenylation site and varied significantly in their relative abundance .", "entity": [{"entity": "BHV - 1 UL24", "entity_type": "GENE", "pos": [4, 16]}, {"entity": "UL25", "entity_type": "GENE", "pos": [19, 23]}, {"entity": "UL26", "entity_type": "GENE", "pos": [26, 30]}, {"entity": "UL26 . 5 transcripts", "entity_type": "GENE", "pos": [35, 55]}], "task": "NER"}
{"text": "Ligand binding of multi - chain antigen receptors and hematopoietin / cytokine receptors results in rapid activation of protein tyrosine kinase ( PTK ) - dependent signalling molecules such as phosphatidylinositol 3 - kinase ( PI 3 - kinase ) .", "entity": [{"entity": "hematopoietin", "entity_type": "GENE", "pos": [54, 67]}, {"entity": "protein tyrosine kinase", "entity_type": "GENE", "pos": [120, 143]}, {"entity": "PTK", "entity_type": "GENE", "pos": [146, 149]}, {"entity": "phosphatidylinositol 3 - kinase", "entity_type": "GENE", "pos": [193, 224]}, {"entity": "PI 3 - kinase", "entity_type": "GENE", "pos": [227, 240]}], "task": "NER"}
{"text": "Post - CPB cardiac index was superior in group B ( 3 . 9 + / - 0 . 3 vs .", "entity": [], "task": "NER"}
{"text": "The regulatory genes cnrYXH have been cloned , overexpressed , and purified in Escherichia coli .", "entity": [{"entity": "cnrYXH", "entity_type": "GENE", "pos": [21, 27]}], "task": "NER"}
{"text": "Cognitive measures of attention included the Stroop and Controlled Oral Word Association Test using the letters \" C , \" \" F , \" and \" L \" ( COWAT , CFL version ) .", "entity": [], "task": "NER"}
{"text": "The objectives of this study were 1 ) to quantify the comparative structural static and fatigue properties of the pointe shoe toe box , and 2 ) to evaluate the preferred shoe characteristics as determined by a survey of local dancers .", "entity": [], "task": "NER"}
{"text": "When linked to the herpes simplex thymidine kinase minimal promoter , this fragment acts as an enhancing element in Rcho but not GC cells .", "entity": [{"entity": "thymidine kinase", "entity_type": "GENE", "pos": [34, 50]}], "task": "NER"}
{"text": "We report on a case of a 43 - old - male with a bronchogenic cyst in the distal esophagus , which was misdiagnosed as a malignant esophageal tumor based on preoperative imaging and high levels of the tumor markers CA 19 - 9 and CA 125 .", "entity": [{"entity": "CA 19 - 9", "entity_type": "GENE", "pos": [214, 223]}, {"entity": "CA 125", "entity_type": "GENE", "pos": [228, 234]}], "task": "NER"}
{"text": "Oscillatory flow is reestablished in the model at the capillary - cerebrospinal fluid and capillary - venous interfaces .", "entity": [], "task": "NER"}
{"text": "This substrate was cleaved efficiently in trans by protease 3C derived from another recombinant vaccinia virus expressing a 3C precursor protein .", "entity": [{"entity": "protease 3C", "entity_type": "GENE", "pos": [51, 62]}, {"entity": "3C precursor protein", "entity_type": "GENE", "pos": [124, 144]}], "task": "NER"}
{"text": "Human and murine cytotoxic T lymphocyte serine proteases : subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins .", "entity": [{"entity": "Human and murine cytotoxic T lymphocyte serine proteases", "entity_type": "GENE", "pos": [0, 56]}], "task": "NER"}
{"text": "The human Fc gamma receptor gene Fc gamma RIIA is expressed in platelets , neutrophils , monocytes and macrophages .", "entity": [{"entity": "human Fc gamma receptor gene", "entity_type": "GENE", "pos": [4, 32]}, {"entity": "Fc gamma RIIA", "entity_type": "GENE", "pos": [33, 46]}], "task": "NER"}
{"text": "Like the nuclear envelope , the intranuclear double membrane lamellae enclosed a defined cisterna that was interrupted by pores but , unlike the nuclear envelope pores , they lacked NPCs .", "entity": [], "task": "NER"}
{"text": "Regulation of the human stress response gene GADD153 expression : role of ETS1 and FLI - 1 gene products .", "entity": [{"entity": "human stress response gene GADD153", "entity_type": "GENE", "pos": [18, 52]}, {"entity": "ETS1", "entity_type": "GENE", "pos": [74, 78]}, {"entity": "FLI - 1 gene products", "entity_type": "GENE", "pos": [83, 104]}], "task": "NER"}
{"text": "On days 7 , 21 , and 35 postinoculation ( PI ) , all birds received sheep erythrocytes intravenously .", "entity": [], "task": "NER"}
{"text": "The higher level of calories was attained by an increased intake of carbohydrates .", "entity": [], "task": "NER"}
{"text": "However , it is now suggested that the use of more slowly digested starchy foods may have positive health benefits .", "entity": [], "task": "NER"}
{"text": "Each receptor must therefore engage a unique subset of the available signaling elements - - at least partly through the selection of proteins with src - homology 2 domains ( SH2 proteins ) .", "entity": [{"entity": "src - homology 2 domains", "entity_type": "GENE", "pos": [147, 171]}, {"entity": "SH2 proteins", "entity_type": "GENE", "pos": [174, 186]}], "task": "NER"}
{"text": "Hence , it is perhaps not necessary to perform spinal puncture if the only purpose is to determine the CSF / serum ratio .", "entity": [], "task": "NER"}
{"text": "NSAIDS and the microcirculation of the stomach .", "entity": [], "task": "NER"}
{"text": "Highly significant similarities were detected between the N - terminal region of P30 and those of GENA [ the product of another unidentified gene ( geneA ) located upstream of the aceEF - lpd operon ] , and GNTR ( a putative transcriptional repressor of the gluconate operon of Bacillus subtilis ) .", "entity": [{"entity": "P30", "entity_type": "GENE", "pos": [81, 84]}, {"entity": "GENA", "entity_type": "GENE", "pos": [98, 102]}, {"entity": "geneA", "entity_type": "GENE", "pos": [148, 153]}, {"entity": "aceEF", "entity_type": "GENE", "pos": [180, 185]}, {"entity": "lpd", "entity_type": "GENE", "pos": [188, 191]}, {"entity": "GNTR", "entity_type": "GENE", "pos": [207, 211]}, {"entity": "gluconate operon", "entity_type": "GENE", "pos": [258, 274]}], "task": "NER"}
{"text": "Promoting fat utilisation by reducing the carbohydrate - fat ratio of the TPN reduces free radical activity to a similar extent as fat exclusion .", "entity": [], "task": "NER"}
{"text": "It is postulated that the synthesis of the peptidoglycan layer was affected by the antimetabolites since the morphological effects were strikingly similar to those caused by treatment of E . cloacae with disodium edetate plus lysozyme .", "entity": [{"entity": "lysozyme", "entity_type": "GENE", "pos": [226, 234]}], "task": "NER"}
{"text": "The selective 5 - HT2 receptor blocker ketanserin was found to reduce maximal urethral pressures in healthy females by about 40 % without reducing blood pressure .", "entity": [{"entity": "5 - HT2 receptor", "entity_type": "GENE", "pos": [14, 30]}], "task": "NER"}
{"text": "RESULTS : Of 10 , 709 , 701 chemistry specimens submitted to the participating laboratories during the data collection period , 37 , 208 ( 0 . 35 % ) were rejected prior to testing .", "entity": [], "task": "NER"}
{"text": "Interestingly , VDR was able to bind to VDREs with high affinity and to fully activate transcription in intact yeast cells in the presence of the retinoid X receptor ( RXR ) .", "entity": [{"entity": "VDR", "entity_type": "GENE", "pos": [16, 19]}, {"entity": "retinoid X receptor", "entity_type": "GENE", "pos": [146, 165]}, {"entity": "RXR", "entity_type": "GENE", "pos": [168, 171]}], "task": "NER"}
{"text": "The newly identified repressor element is a rare example of a naturally occurring perfect palindromic binding motif for the NF - kappa B / Rel family of transcription factors .", "entity": [{"entity": "NF - kappa B", "entity_type": "GENE", "pos": [124, 136]}, {"entity": "Rel", "entity_type": "GENE", "pos": [139, 142]}], "task": "NER"}
{"text": "UV - cross - linking studies suggested that these two complexes represent one and two molecules of ADR1 bound to DNA .", "entity": [{"entity": "ADR1", "entity_type": "GENE", "pos": [99, 103]}], "task": "NER"}
{"text": "Finally , the conservation of the two residues most sensitive to mutations ( Y949 and Y953 ) in TM11 , and in the homologous TM5 , of all mammalian P - gps and also in other ABC transporters , suggests that these residues and domains may play an important role in structural as well as mechanistic aspects common to this family of proteins .", "entity": [{"entity": "mammalian P - gps", "entity_type": "GENE", "pos": [138, 155]}, {"entity": "ABC transporters", "entity_type": "GENE", "pos": [174, 190]}], "task": "NER"}
{"text": "SF1 / mBBP utilizes a \" maxi - K homology \" ( maxi - KH ) domain for recognition of the single - stranded BPS and requires a cooperative interaction with splicing factor U2AF65 bound to an adjacent polypyrimidine tract ( PPT ) for high - affinity binding .", "entity": [{"entity": "SF1", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "mBBP", "entity_type": "GENE", "pos": [6, 10]}, {"entity": "\" maxi - K homology \"", "entity_type": "GENE", "pos": [22, 43]}, {"entity": "maxi - KH", "entity_type": "GENE", "pos": [46, 55]}, {"entity": "U2AF65", "entity_type": "GENE", "pos": [170, 176]}], "task": "NER"}
{"text": "The in vivo response of the PacC - like decamers to external pH was dependent on the status of the pH - regulated activator YlRim101p , which is homologous to the A . nidulans PacC regulator .", "entity": [{"entity": "PacC - like decamers", "entity_type": "GENE", "pos": [28, 48]}, {"entity": "YlRim101p", "entity_type": "GENE", "pos": [124, 133]}, {"entity": "PacC", "entity_type": "GENE", "pos": [176, 180]}], "task": "NER"}
{"text": "Spongiosa regeneration in the millipore chamber", "entity": [], "task": "NER"}
{"text": "MTX therapy decreased Ga - 67 uptake in liver , tumor , and muscle .", "entity": [], "task": "NER"}
{"text": "Each of these materials were placed by means of three different placement techniques ( Bulk pack , Horizontal layering and Vertical layering ) into class II cavities in extracted human molars .", "entity": [], "task": "NER"}
{"text": "In contrast , the sequences essential for the transcription of EFT1 were localized to the region between the start ATG and the stop codon of the VPS17 gene that terminates 267 nt upstream on the same strand .", "entity": [{"entity": "EFT1", "entity_type": "GENE", "pos": [63, 67]}, {"entity": "VPS17 gene", "entity_type": "GENE", "pos": [145, 155]}], "task": "NER"}
{"text": "No transactivation of the ovalbumin promoter ( pLovTATA ) template control was observed .", "entity": [{"entity": "ovalbumin promoter", "entity_type": "GENE", "pos": [26, 44]}, {"entity": "pLovTATA", "entity_type": "GENE", "pos": [47, 55]}], "task": "NER"}
{"text": "Removal of cyclin - dependant kinases ( cdks ) or cdk2 from these extracts using affinity matrices severely inhibits initiation of S phase .", "entity": [{"entity": "cyclin - dependant kinases", "entity_type": "GENE", "pos": [11, 37]}, {"entity": "cdks", "entity_type": "GENE", "pos": [40, 44]}, {"entity": "cdk2", "entity_type": "GENE", "pos": [50, 54]}], "task": "NER"}
{"text": "Consistent with this hypothesis , stimulation of A ( 2A ) - R or PKA enhanced nuclear aPKC activity .", "entity": [{"entity": "A ( 2A ) - R", "entity_type": "GENE", "pos": [49, 61]}, {"entity": "PKA", "entity_type": "GENE", "pos": [65, 68]}, {"entity": "nuclear aPKC", "entity_type": "GENE", "pos": [78, 90]}], "task": "NER"}
{"text": "Foreign DNA inserts contained within the fowlpox virus sequence were transferred to the viral genome by homologous recombination occurring in cells infected with a fowlpox virus temperature - sensitive mutant and transfected with both wild - type viral DNA and plasmid DNA .", "entity": [], "task": "NER"}
{"text": "JCAHO to use ORYX data to detect sentinel events .", "entity": [], "task": "NER"}
{"text": "Comparisons of the efficacy of benazepril and hydrochlorothiazide alone and in combination have shown that benazepril 20 mg once daily is as effective as or more effective in lowering diastolic blood pressure than hydrochlorothiazide 25 mg once daily and that the combination of benazepril 20 mg and hydrochlorothiazide 25 mg has a possibly synergistic effect on diastolic blood pressure .", "entity": [], "task": "NER"}
{"text": "Carcinoma - related protein production may have played a role in the development of the observed renal lesions .", "entity": [{"entity": "Carcinoma - related protein", "entity_type": "GENE", "pos": [0, 27]}], "task": "NER"}
{"text": "METHODS : The study population included 70 patients with acute coronary syndromes ( 14 with recent acute myocardial infarction and 56 with unstable angina pectoris ) , 105 patients with stable angina pectoris , and 75 control subjects .", "entity": [], "task": "NER"}
{"text": "Single amino acid substitutions were shown to result from the mutations pdr1 - 2 ( M308I ) , pdr1 - 3 ( F815S ) , pdr1 - 6 ( K302Q ) , pdr1 - 7 ( P298A ) and pdr1 - 8 ( L1036 W ) , whereas the intragenic suppressor mutant pdr1 - 100 is deleted for the two amino acids L537 and A538 .", "entity": [{"entity": "pdr1 - 2", "entity_type": "GENE", "pos": [72, 80]}, {"entity": "pdr1 - 3", "entity_type": "GENE", "pos": [93, 101]}, {"entity": "pdr1 - 6", "entity_type": "GENE", "pos": [114, 122]}, {"entity": "pdr1 - 7", "entity_type": "GENE", "pos": [135, 143]}, {"entity": "pdr1 - 8", "entity_type": "GENE", "pos": [158, 166]}, {"entity": "pdr1 - 100", "entity_type": "GENE", "pos": [222, 232]}], "task": "NER"}
{"text": "However , no statistical difference in the Ca / P ratio , carbon concentration and surface energy were observed with different heat treatments .", "entity": [], "task": "NER"}
{"text": "These motions were found in the N - and C - terminal tails , in segment 33 - 35 which forms the turn between beta - strands S1 and S2 , and residues 47 - 52 located in a long loop preceding strand S3 .", "entity": [], "task": "NER"}
{"text": "Enterobius vermicularis eggs were demonstrated during microscopic examination of a smear taken from the posterior fornix of the vagina .", "entity": [], "task": "NER"}
{"text": "Differentiation of porcine mycoplasma strains by means of a simple paper chromatography test .", "entity": [], "task": "NER"}
{"text": "D . , Hughes , F .", "entity": [], "task": "NER"}
{"text": "We further showed a significant repression of promoter activity ( > 40 fold ) by E2 - 2 ( lacking the amino acid sequence RSRS ) when the E47 reporter construct , containing a hexameric E - box site , was used .", "entity": [{"entity": "E2 - 2", "entity_type": "GENE", "pos": [81, 87]}, {"entity": "E47 reporter construct", "entity_type": "GENE", "pos": [138, 160]}], "task": "NER"}
{"text": "Sequence analysis of AEBP2 cDNA revealed that it encodes a protein containing three Gli - Kruppel ( Cys2 - His2 ) - type zinc fingers .", "entity": [{"entity": "AEBP2 cDNA", "entity_type": "GENE", "pos": [21, 31]}, {"entity": "Gli", "entity_type": "GENE", "pos": [84, 87]}, {"entity": "Kruppel", "entity_type": "GENE", "pos": [90, 97]}], "task": "NER"}
{"text": "METHODS : The prevalence of haemagglutination inhibiting ( HI ) antibodies to JE virus ( JEV ) , West Nile virus ( WNV ) and dengue - 2 virus ( DEN - 2 ) was detected by HI test and IgM antibody capture ELISA ( MAC ELISA ) was performed to determine recent infections with JE virus .", "entity": [{"entity": "haemagglutination inhibiting ( HI ) antibodies", "entity_type": "GENE", "pos": [28, 74]}, {"entity": "IgM antibody", "entity_type": "GENE", "pos": [182, 194]}], "task": "NER"}
{"text": "To elucidate the mechanism of these hormonal effects , we have studied the regulatory regions of the PFK - 2 gene in transfection experiments .", "entity": [{"entity": "PFK - 2 gene", "entity_type": "GENE", "pos": [101, 113]}], "task": "NER"}
{"text": "Tryptophan induction prevents Rho - dependent transcription termination in the leader region of the operon .", "entity": [{"entity": "Rho", "entity_type": "GENE", "pos": [30, 33]}], "task": "NER"}
{"text": "An in vitro Raf - 1 kinase assay , however , failed to detect LPS - induced Raf - 1 kinase activity in RAW 264 . 7 cells , suggesting that in RAW 264 . 7 cells , Raf - 1 kinase is not an activating component of the LPS signaling pathway regulating MAPK activity or sIL - 1Ra promoter activity .", "entity": [{"entity": "Raf - 1 kinase", "entity_type": "GENE", "pos": [12, 26]}, {"entity": "Raf - 1 kinase", "entity_type": "GENE", "pos": [76, 90]}, {"entity": "Raf - 1 kinase", "entity_type": "GENE", "pos": [162, 176]}, {"entity": "MAPK", "entity_type": "GENE", "pos": [248, 252]}, {"entity": "sIL - 1Ra promoter", "entity_type": "GENE", "pos": [265, 283]}], "task": "NER"}
{"text": "Subjects were 73 male and female employees of the Xerox Corporation joining a newly developed health fitness program .", "entity": [], "task": "NER"}
{"text": "The LT - beta gene is expressed in lymphoid cells and organs , but little is known about its inducible regulation .", "entity": [{"entity": "LT - beta gene", "entity_type": "GENE", "pos": [4, 18]}], "task": "NER"}
{"text": "Dose - dependent pharmacokinetics : emphasis on phase I metabolism .", "entity": [], "task": "NER"}
{"text": "There were no differences in the incidence of fractured zonas .", "entity": [], "task": "NER"}
{"text": "Our Northern and Southern blot analyses of meningiomas clearly suggest the CLH - 22 gene may be involved in the tumor development and can be considered as a candidate for a tumor suppressor .", "entity": [{"entity": "CLH - 22 gene", "entity_type": "GENE", "pos": [75, 88]}], "task": "NER"}
{"text": "The difference between the results in the high dose AHLG and in the control group was significant ( p less than 0 . 05 ) .", "entity": [{"entity": "AHLG", "entity_type": "GENE", "pos": [52, 56]}], "task": "NER"}
{"text": "The stress / BHV - 1 model resulted in a mild respiratory infection in all calves with no difference observed between treatment groups .", "entity": [], "task": "NER"}
{"text": "Cytomegalovirus infection - - modern diagnosis", "entity": [], "task": "NER"}
{"text": "Genomic organization of the human multidrug resistance ( MDR1 ) gene and origin of P - glycoproteins .", "entity": [{"entity": "human multidrug resistance ( MDR1 ) gene", "entity_type": "GENE", "pos": [28, 68]}, {"entity": "P - glycoproteins", "entity_type": "GENE", "pos": [83, 100]}], "task": "NER"}
{"text": "The pepI gene was overexpressed in Escherichia coli .", "entity": [{"entity": "pepI gene", "entity_type": "GENE", "pos": [4, 13]}], "task": "NER"}
{"text": "Deep bite CL II Div .", "entity": [], "task": "NER"}
{"text": "Negative modulation of alpha1 ( I ) procollagen gene expression in human skin fibroblasts : transcriptional inhibition by interferon - gamma .", "entity": [{"entity": "alpha1 ( I ) procollagen gene", "entity_type": "GENE", "pos": [23, 52]}, {"entity": "interferon - gamma", "entity_type": "GENE", "pos": [122, 140]}], "task": "NER"}
{"text": "Yet IL - 2 and IFN - gamma production are independently regulated , as demonstrated by their differential expression in certain T cell subsets , suggesting that the regulatory elements in these two genes must differ .", "entity": [{"entity": "IL - 2", "entity_type": "GENE", "pos": [4, 10]}, {"entity": "IFN - gamma", "entity_type": "GENE", "pos": [15, 26]}], "task": "NER"}
{"text": "In summary , FGFR3 signaling pathway utilizes two GRB2 - containing complexes ; Shc . GRB2 . Sos and 80K - H . pp66 . GRB2 . Sos ; these two complexes may alternatively link FGFG3 to mitogen - activated protein kinase .", "entity": [{"entity": "FGFR3", "entity_type": "GENE", "pos": [13, 18]}, {"entity": "GRB2 - containing complexes", "entity_type": "GENE", "pos": [50, 77]}, {"entity": "Shc", "entity_type": "GENE", "pos": [80, 83]}, {"entity": "GRB2", "entity_type": "GENE", "pos": [86, 90]}, {"entity": "Sos", "entity_type": "GENE", "pos": [93, 96]}, {"entity": "80K - H", "entity_type": "GENE", "pos": [101, 108]}, {"entity": "pp66", "entity_type": "GENE", "pos": [111, 115]}, {"entity": "GRB2", "entity_type": "GENE", "pos": [118, 122]}, {"entity": "Sos", "entity_type": "GENE", "pos": [125, 128]}, {"entity": "FGFG3", "entity_type": "GENE", "pos": [174, 179]}, {"entity": "mitogen - activated protein kinase", "entity_type": "GENE", "pos": [183, 217]}], "task": "NER"}
{"text": "Resistance to Mup was classified as low ( minimal inhibitory concentration [ MIC ] > or = 8 microg / mL ) or high ( MIC > or = 512 microg / mL ) degree .", "entity": [], "task": "NER"}
{"text": "STUDY DESIGN : Retrospective review .", "entity": [], "task": "NER"}
{"text": "One had a 48 - hour cycle and the other a 24 - hour cycle .", "entity": [], "task": "NER"}
{"text": "1 The effects of high doses of piretanide , a new diuretic agent chemically related to frusemide and bumetanide were evaluated in twelve patients with severe chronic renal insufficiency ( creatinine clearance below 25 ml / min ) .", "entity": [], "task": "NER"}
{"text": "S1 nuclease protection mapping and primer extension analysis allowed us to propose that the A residue located 19 bp upstream from the translation initiation codon is the site of transcription initiation .", "entity": [{"entity": "S1 nuclease", "entity_type": "GENE", "pos": [0, 11]}], "task": "NER"}
{"text": "Various stimuli inactivate IkappaB alpha by triggering phosphorylation of the N - terminal residues Ser32 and Ser36 .", "entity": [{"entity": "IkappaB alpha", "entity_type": "GENE", "pos": [27, 40]}], "task": "NER"}
{"text": "A mouse brain cDNA library in lambdagt11 was screened for this association , and two positive clones encoding tyrosine phosphatase SH - PTP2 were isolated .", "entity": [{"entity": "tyrosine phosphatase", "entity_type": "GENE", "pos": [110, 130]}, {"entity": "SH - PTP2", "entity_type": "GENE", "pos": [131, 140]}], "task": "NER"}
{"text": "Intensive therapy of viral hepatitis", "entity": [], "task": "NER"}
{"text": "Adjusting a steady - state warfarin dose depends on the measured INR values and clinical factors : the dose does not need to be adjusted for a single INR that is slightly out of range , and most changes should alter the total weekly dose by 5 % to 20 % .", "entity": [], "task": "NER"}
{"text": "Successful resolution of progressive multifocal leukoencephalopathy after combination therapy with cidofovir and cytosine arabinoside .", "entity": [], "task": "NER"}
{"text": "The DFGF - R protein may thus participate in receiving spatial cues that guide tracheal cell outgrowth .", "entity": [{"entity": "DFGF - R protein", "entity_type": "GENE", "pos": [4, 20]}], "task": "NER"}
{"text": "FTF ( Joint Council of Civil Servants and Functionaries ) : clarification about membership in the main organizations", "entity": [], "task": "NER"}
{"text": "The differences in binding ( Kdapp ) , incorporation , and extension kinetics of 8 - oxo - dGTP compared to normal dNTP incorporation at template 8 - oxo - G adducts indicate that polymerase fidelity does not depend solely upon the overall geometry of Watson - Crick base pairs and reflects the asymmetry of the enzyme active site .", "entity": [], "task": "NER"}
{"text": "Retroviral vector producer cell populations and cell clones were established for each chLTR vector , and all were capable of yielding high vector titers ( > 10 ( 5 ) G418R cfu / ml on NIH - 3T3 ) .", "entity": [{"entity": "chLTR", "entity_type": "GENE", "pos": [86, 91]}, {"entity": "G418R", "entity_type": "GENE", "pos": [166, 171]}], "task": "NER"}
{"text": "None of these patients developed clinical events before disappearance of the phospholipid - dependent inhibitors of coagulation .", "entity": [], "task": "NER"}
{"text": "A high titer of anti - HBc , thus suggested to be an indicator of persistent hepatitis B virus infection , was found rarely in seronegative patients with chronic hepatitis , non - alcoholic cirrhosis , or alcoholic liver diseases .", "entity": [{"entity": "anti - HBc", "entity_type": "GENE", "pos": [16, 26]}], "task": "NER"}
{"text": "Using beta 1 - AR - luciferase reporter recombinants , we have previously determined that important beta 1 - AR genetic elements controlling expression within the C6 glioma cell line are contained within the region - 396 to - 299 , relative to the translational start site .", "entity": [{"entity": "beta 1 - AR", "entity_type": "GENE", "pos": [6, 17]}, {"entity": "luciferase", "entity_type": "GENE", "pos": [20, 30]}, {"entity": "beta 1 - AR", "entity_type": "GENE", "pos": [100, 111]}], "task": "NER"}
{"text": "It is not well known that giant cell arteritis can cause fatal complications due to rupture of aortic aneurysms or cerebral and myocardial infarctions .", "entity": [], "task": "NER"}
{"text": "Temporal recruitment of the mSin3A - histone deacetylase corepressor complex to the ETS domain transcription factor Elk - 1 .", "entity": [{"entity": "mSin3A", "entity_type": "GENE", "pos": [28, 34]}, {"entity": "histone deacetylase", "entity_type": "GENE", "pos": [37, 56]}, {"entity": "ETS domain transcription factor", "entity_type": "GENE", "pos": [84, 115]}, {"entity": "Elk - 1", "entity_type": "GENE", "pos": [116, 123]}], "task": "NER"}
{"text": "By screening a human testis cDNA library with a probe containing the mouse PEA3 ETS domain , we isolated a 2 . 2 kb clone containing a 510 AA open reading frame .", "entity": [{"entity": "mouse PEA3", "entity_type": "GENE", "pos": [69, 79]}, {"entity": "ETS", "entity_type": "GENE", "pos": [80, 83]}], "task": "NER"}
{"text": "It is also affected by the HAP2 / 3 / 4 transcription factor complex and by SNF1 and SSN6 .", "entity": [{"entity": "HAP2 / 3 / 4 transcription factor complex", "entity_type": "GENE", "pos": [27, 68]}, {"entity": "SNF1", "entity_type": "GENE", "pos": [76, 80]}, {"entity": "SSN6", "entity_type": "GENE", "pos": [85, 89]}], "task": "NER"}
{"text": "The gene is predicted to encode an 880 - amino - acid protein which contains two C2H2 zinc fingers , a nuclear localization sequence and two transcriptional activation domains .", "entity": [], "task": "NER"}
{"text": "These results indicate that H - 2RIIBP ( i ) is a member of the superfamily of nuclear hormone receptors and ( ii ) may regulate not only MHC class I genes but also genes containing the ERE and related sequences .", "entity": [{"entity": "H - 2RIIBP", "entity_type": "GENE", "pos": [28, 38]}, {"entity": "nuclear hormone receptors", "entity_type": "GENE", "pos": [79, 104]}, {"entity": "MHC class I genes", "entity_type": "GENE", "pos": [138, 155]}], "task": "NER"}
{"text": "Relaxant effect of prostaglandin E1 ( PGE1 ) and papaverine ( PAP ) were measured in strips of corpus cavernosum smooth muscle taken from a healthy control group of men ( A ; n = 5 ) , from arteriogenically impotent men ( B ; n = 6 ) and from additionally diabetic impotent men ( C ; n = 5 ) with venous leakage .", "entity": [], "task": "NER"}
{"text": "The sensitivity of central dopamine receptors was assessed with the growth hormone response to apomorphine application .", "entity": [{"entity": "central dopamine receptors", "entity_type": "GENE", "pos": [19, 45]}, {"entity": "growth hormone", "entity_type": "GENE", "pos": [68, 82]}], "task": "NER"}
{"text": "Pathogenesis of fever .", "entity": [], "task": "NER"}
{"text": "The occurrence of the different types of TCRB rearrangement patterns has implications for PCR - based clonality assessment and for PCR - based detection of minimal residual disease via TCRB gene analysis .", "entity": [{"entity": "TCRB", "entity_type": "GENE", "pos": [41, 45]}, {"entity": "TCRB gene", "entity_type": "GENE", "pos": [185, 194]}], "task": "NER"}
{"text": "In many other contractile protein gene families , genes encoding cardiac isoforms are expressed early in skeletal muscle development and are later repressed .", "entity": [], "task": "NER"}
{"text": "The NH2 - terminal fragments were tested for susceptibility to modification with Nalpha - ( 3 - maleimidylpropionyl ) biocytin , which attaches a biotin group to cysteine sulfhydryls .", "entity": [], "task": "NER"}
{"text": "Directional growth of a smectic - A - smectic - B interface lying along a forbidden orientation .", "entity": [], "task": "NER"}
{"text": "METHODS : We performed nasal mupirocin treatment on 10 infants who were MRSA - positive either in the nose or the pharynx and evaluated the effect of mupirocin on the eradication of MRSA .", "entity": [], "task": "NER"}
{"text": "TOM1 encodes a member of the hect - domain - containing E3 ubiquitin - protein ligase family that is required for growth at elevated temperatures .", "entity": [{"entity": "TOM1", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "hect", "entity_type": "GENE", "pos": [29, 33]}, {"entity": "E3", "entity_type": "GENE", "pos": [56, 58]}, {"entity": "ubiquitin - protein ligase", "entity_type": "GENE", "pos": [59, 85]}], "task": "NER"}
{"text": "Purified preparations of all four AGT mutants showed an approximately similar degree ( 74 - 120 - fold ) of reduction in the rate of reaction with O6 - benzylguanine .", "entity": [], "task": "NER"}
{"text": "These results demonstrate that m2 receptors couple to both G alpha i2 and G alpha i3 in vivo and that this interaction is integral to both positive and negative regulatory pathways leading to activation of PLC and desensitization of receptor signaling .", "entity": [{"entity": "m2 receptors", "entity_type": "GENE", "pos": [31, 43]}, {"entity": "G alpha i2", "entity_type": "GENE", "pos": [59, 69]}, {"entity": "G alpha i3", "entity_type": "GENE", "pos": [74, 84]}, {"entity": "PLC", "entity_type": "GENE", "pos": [206, 209]}], "task": "NER"}
{"text": "This is the first clinical case report of NIHF due to fetal Kasabach - Merritt syndrome that was prenatally diagnosed by sonography , computerized tomography , and percutaneous umbilical blood sampling .", "entity": [], "task": "NER"}
{"text": "The cholesterol 7alpha - hydroxylase gene ( CYP7A ) is transcriptionally regulated by a number of factors , including hormones , bile acids , and diurnal rhythm .", "entity": [{"entity": "cholesterol 7alpha - hydroxylase gene", "entity_type": "GENE", "pos": [4, 41]}, {"entity": "CYP7A", "entity_type": "GENE", "pos": [44, 49]}], "task": "NER"}
{"text": "Restriction mapping showed that the two recombinant plasmids shared an EcoRI fragment of 8 . 9 kb .", "entity": [{"entity": "EcoRI fragment", "entity_type": "GENE", "pos": [71, 85]}], "task": "NER"}
{"text": "Two mutants , mapping at the HindIII site ( between the consensus sequences ) of the pSC101 tetA promoter , were studied : MA2 corresponds to a 4 bp deletion between positions - 12 and - 15 ; B30 bears a 44 bp insertion C ( TA ) 21 G at the HindIII site .", "entity": [{"entity": "HindIII site", "entity_type": "GENE", "pos": [29, 41]}, {"entity": "pSC101 tetA promoter", "entity_type": "GENE", "pos": [85, 105]}, {"entity": "HindIII site", "entity_type": "GENE", "pos": [241, 253]}], "task": "NER"}
{"text": "Meq / c - Jun heterodimers bind to an AP1 - like sequence in the meq promoter region with an affinity much greater than that of Meq / Meq or c - Jun / c - Jun homodimers .", "entity": [{"entity": "Meq", "entity_type": "GENE", "pos": [0, 3]}, {"entity": "c - Jun", "entity_type": "GENE", "pos": [6, 13]}, {"entity": "AP1 - like sequence", "entity_type": "GENE", "pos": [38, 57]}, {"entity": "meq promoter region", "entity_type": "GENE", "pos": [65, 84]}, {"entity": "Meq", "entity_type": "GENE", "pos": [128, 131]}, {"entity": "Meq", "entity_type": "GENE", "pos": [134, 137]}, {"entity": "c - Jun", "entity_type": "GENE", "pos": [141, 148]}, {"entity": "c - Jun", "entity_type": "GENE", "pos": [151, 158]}], "task": "NER"}
{"text": "Infra - red spectroscopy of tissues in the 700 - 400 cm - 1 region .", "entity": [], "task": "NER"}
{"text": "Although no detectable phenotypes are associated with a disruption allele of ABP1 , mutations that create a requirement for this protein have now been isolated in the previously identified gene SAC6 and in two new genes , SLA1 and SLA2 .", "entity": [{"entity": "ABP1", "entity_type": "GENE", "pos": [77, 81]}, {"entity": "gene SAC6", "entity_type": "GENE", "pos": [189, 198]}, {"entity": "SLA1", "entity_type": "GENE", "pos": [222, 226]}, {"entity": "SLA2", "entity_type": "GENE", "pos": [231, 235]}], "task": "NER"}
{"text": "Comparison of bioreactive and immunoreactive gastrin .", "entity": [{"entity": "gastrin", "entity_type": "GENE", "pos": [45, 52]}], "task": "NER"}
{"text": "The claustrocortical connection was investigated in 13 cats with selective injections of 30 % HRP in the three subdivisions of the auditory cortex . ( ABSTRACT TRUNCATED AT 400 WORDS )", "entity": [], "task": "NER"}
{"text": "The authors report a case of a painful wrist related to a \" Manieux muscle \" of the dorsal aspect of the hand .", "entity": [], "task": "NER"}
{"text": "A significant reduction in total cellular p27 protein levels and a moderate reduction in p27 mRNA are observed , but no changes in Cdk regulatory kinases and phosphatases occur .", "entity": [{"entity": "p27 protein", "entity_type": "GENE", "pos": [42, 53]}, {"entity": "p27 mRNA", "entity_type": "GENE", "pos": [89, 97]}, {"entity": "Cdk", "entity_type": "GENE", "pos": [131, 134]}], "task": "NER"}
{"text": "This result , together with the fact that unrearranged V kappa genes are transcriptionally silent , suggests that structural features of both the V kappa and C kappa loci contribute to the overall transcriptional efficiency of a rearranged V kappa - C kappa gene .", "entity": [{"entity": "unrearranged V kappa genes", "entity_type": "GENE", "pos": [42, 68]}, {"entity": "V kappa", "entity_type": "GENE", "pos": [146, 153]}, {"entity": "C kappa loci", "entity_type": "GENE", "pos": [158, 170]}, {"entity": "rearranged V kappa - C kappa gene", "entity_type": "GENE", "pos": [229, 262]}], "task": "NER"}
{"text": "Level II mosaicism occurred in 0 . 9 per cent of CVS mesenchyme and 1 . 5 per cent of amniotic fluid cultures and in general was not perceived to be of sufficient concern to warrant cytogenetic follow - up studies .", "entity": [], "task": "NER"}
{"text": "Measures of sedation , BIS , deltaBIS ( absolute change of BIS after a painful stimulus ) , memory , and drug concentration were obtained at each target drug concentration .", "entity": [], "task": "NER"}
{"text": "There are three types of problems : problems arising before the drug enters the body ( solubilization , stabilization and improved acceptability ) ; problems associated with the penetration and fate of the drug in the body ( absorption , barrier crossing , duration of action ) ; problems relating to the therapeutic target ( selective local delivery ) .", "entity": [], "task": "NER"}
{"text": "The structure elucidation of the iridoid compounds 2 and 3 are discussed in detail .", "entity": [], "task": "NER"}
{"text": "Characterization of trinucleotide - and tandem repeat - containing transcripts obtained from human spinal cord cDNA library by high - density filter hybridization .", "entity": [], "task": "NER"}
{"text": "CONCLUSION : Urbanisation is associated with an increase in the prevalence rates of some risk behaviours .", "entity": [], "task": "NER"}
{"text": "The authors emphasize absence of specific signs of vagal involvement , importance for diagnosis of surgical extirpation , and mildness of post operative course .", "entity": [], "task": "NER"}
{"text": "Growth factors promote cell survival through phosphorylation of Bad , resulting in its dissociation from Bcl - 2 and Bcl - x ( L ) and its association with 14 - 3 - 3tau .", "entity": [{"entity": "Bad", "entity_type": "GENE", "pos": [64, 67]}, {"entity": "Bcl - 2", "entity_type": "GENE", "pos": [105, 112]}, {"entity": "Bcl - x ( L )", "entity_type": "GENE", "pos": [117, 130]}, {"entity": "14 - 3 - 3tau", "entity_type": "GENE", "pos": [156, 169]}], "task": "NER"}
{"text": "Both in the Federal Republic of Germany and in some neighbouring countries the epizootic situation of Aujeszky ' s disease has been unsatisfactory for a long time , especially in areas with a high pig density .", "entity": [], "task": "NER"}
{"text": "The sensitivity of 99mTc - IgG scintigraphy ranged between 71 % and 100 % .", "entity": [{"entity": "IgG", "entity_type": "GENE", "pos": [27, 30]}], "task": "NER"}
{"text": "Aggravation of peripheral - blood cytopenia during the first weeks and hypocellularity of bone - marrow aspirates at the end of therapy suggest that low - dose Ara C exerts its main activity by suppression of leukaemic growth , rather than by induction of differentiation in malignant cells .", "entity": [], "task": "NER"}
{"text": "Those participating in this investigation ( 65 centers = 79 % ) received a series of computer disks containing 50 99mTc - DMSA studies .", "entity": [], "task": "NER"}
{"text": "Probiotics , prebiotics , vaccination , and acidification of drinking water were assessed as means of reducing Salmonella .", "entity": [], "task": "NER"}
{"text": "Mutation of this threonine to isoleucine had no observable effect on either nuclear localization of E1 or DNA replication of the intact viral genome .", "entity": [{"entity": "E1", "entity_type": "GENE", "pos": [100, 102]}], "task": "NER"}
{"text": "The inhibition of monoamine oxidase ( MAO ) by tranylcypromine was studied in 6 healthy volunteers given increasing doses of 10 , 15 , 20 and 25 mg / day over a 4 - week period .", "entity": [{"entity": "monoamine oxidase", "entity_type": "GENE", "pos": [18, 35]}, {"entity": "MAO", "entity_type": "GENE", "pos": [38, 41]}], "task": "NER"}
{"text": "Myocardial technetium - 99m - teboroxime uptake during adenosine - induced hyperemia in dogs with either a critical or mild coronary stenosis : comparison to thallium - 201 and regional blood flow .", "entity": [], "task": "NER"}
{"text": "Both atracurium 1 - 100 mumol litre - 1 and laudanosine 1 - 50 mumol litre - 1 enhanced the release of 3H - NA evoked by field stimulation ( 2 Hz , 24 stimuli ) , but did not affect resting release .", "entity": [], "task": "NER"}
{"text": "The recovery of xanthomegnin added to corn samples at levels of 0 . 75 - - 9 . 6 mg / kg averaged 41 % with a coefficient of variation of 25 % .", "entity": [], "task": "NER"}
{"text": "Because of the data , we suggest that LAC9 contacts positions 6 , 7 , and 8 , both plus and minus , of the UAS , which are separated by more than one turn of the DNA helix , and twists part way around the DNA , thus protecting the broad region of the minor groove between the major - groove contacts .", "entity": [{"entity": "LAC9", "entity_type": "GENE", "pos": [38, 42]}], "task": "NER"}
{"text": "Istanbul , Turkey .", "entity": [], "task": "NER"}
{"text": "After Northern blot hybridization , two Cx31 transcripts of 2 . 2 and 1 . 8 kb were detected in total RNA of the human keratinocyte cell line HaCaT and two transcripts of 2 . 2 and 1 . 9 kb in total RNA of E6 / E7 transfected human keratinocytes ( HEK cells ) .", "entity": [{"entity": "Cx31 transcripts of 2 . 2 and 1 . 8 kb", "entity_type": "GENE", "pos": [40, 78]}, {"entity": "E6", "entity_type": "GENE", "pos": [206, 208]}, {"entity": "E7", "entity_type": "GENE", "pos": [211, 213]}], "task": "NER"}
{"text": "While differential expression of the two transcripts was not found , the promoter controlling LT1 / LT2 transcription is regulated in a cell cycle - dependent manner .", "entity": [{"entity": "LT1", "entity_type": "GENE", "pos": [94, 97]}, {"entity": "LT2", "entity_type": "GENE", "pos": [100, 103]}], "task": "NER"}
{"text": "SYC1 ( suppressor of yeast cbf5 - 1 ) was identified as a multicopy suppressor of cbf5 - 1 and subsequently was found to be identical to RRN3 , an RNA polymerase I transcription factor .", "entity": [{"entity": "SYC1", "entity_type": "GENE", "pos": [0, 4]}, {"entity": "suppressor of yeast cbf5 - 1", "entity_type": "GENE", "pos": [7, 35]}, {"entity": "cbf5 - 1", "entity_type": "GENE", "pos": [82, 90]}, {"entity": "RRN3", "entity_type": "GENE", "pos": [137, 141]}, {"entity": "RNA polymerase I transcription factor", "entity_type": "GENE", "pos": [147, 184]}], "task": "NER"}
{"text": "Developmental regulation of expression of the malate synthase gene in transgenic plants .", "entity": [{"entity": "malate synthase gene", "entity_type": "GENE", "pos": [46, 66]}], "task": "NER"}
{"text": "All three SSV - transformed cells secreted v - sis gene product ( p44 ) . p44 was secreted but remained tightly associated with the cell surface .", "entity": [{"entity": "v - sis gene product", "entity_type": "GENE", "pos": [43, 63]}, {"entity": "p44", "entity_type": "GENE", "pos": [66, 69]}, {"entity": "p44", "entity_type": "GENE", "pos": [74, 77]}], "task": "NER"}
{"text": "We also identified a DNA fragment , 10 . 7 kbp upstream from the first coding exon of human aFGF , whose sequence is conserved in both the primate and rodent genomes .", "entity": [{"entity": "human aFGF", "entity_type": "GENE", "pos": [86, 96]}], "task": "NER"}
{"text": "In this respect , the promoter structure of COX genes resemble those of many house - keeping genes .", "entity": [{"entity": "COX genes", "entity_type": "GENE", "pos": [44, 53]}], "task": "NER"}
{"text": "The predicted amino acid sequence of the FlaB2 polypeptide was 92 % identical to that of T . pallidum FlaB2 , with a 76 % identity at the nucleotide level .", "entity": [{"entity": "FlaB2 polypeptide", "entity_type": "GENE", "pos": [41, 58]}, {"entity": "T . pallidum FlaB2", "entity_type": "GENE", "pos": [89, 107]}], "task": "NER"}
{"text": "These data demonstrate that CCTalpha can be regulated by lipids by two independent domains : ( i ) the three amphipathic alpha - helical repeats that interact with both neutral and anionic lipid mixtures and ( ii ) the last 57 residues that interact with anionic lipids .", "entity": [{"entity": "CCTalpha", "entity_type": "GENE", "pos": [28, 36]}], "task": "NER"}
{"text": "Ion - Bernstein - wave heating and improved confinement in the Alcator C tokamak .", "entity": [], "task": "NER"}
{"text": "Of 3841 serum samples from sows received from the Tennessee State Diagnostic Laboratory in 1991 - 1992 , 1130 were positive for Toxoplasma gondii antibody .", "entity": [{"entity": "Toxoplasma gondii antibody", "entity_type": "GENE", "pos": [128, 154]}], "task": "NER"}
{"text": "Morphometry of the intestine of the pig .", "entity": [], "task": "NER"}
{"text": "The subjects were started on indomethacin 25 mg thrice daily .", "entity": [], "task": "NER"}
{"text": "Human parvovirus B19 gene expression from the viral p6 promoter ( B19p6 ) is restricted to primary human hematopoietic cells undergoing erythroid differentiation .", "entity": [{"entity": "Human parvovirus B19 gene", "entity_type": "GENE", "pos": [0, 25]}, {"entity": "viral p6 promoter", "entity_type": "GENE", "pos": [46, 63]}, {"entity": "B19p6", "entity_type": "GENE", "pos": [66, 71]}], "task": "NER"}
{"text": "To further study the role of tTG in liver disease , we initiated investigations into the effect of a proinflammatory mediator , tumor necrosis factor ( TNF ) - alpha , on tTG activity in cultured liver cells .", "entity": [{"entity": "tTG", "entity_type": "GENE", "pos": [29, 32]}, {"entity": "tumor necrosis factor ( TNF ) - alpha", "entity_type": "GENE", "pos": [128, 165]}, {"entity": "tTG", "entity_type": "GENE", "pos": [171, 174]}], "task": "NER"}
{"text": "The atopic disposition , indicated by positive skin reactions and IgE antibody titers etc . , and the bronchial reactivity to inhaled acetylcholine were examined on the following three groups : ( 1 ) 20 young adults with a history of childhood asthma who have been symptom - free for more than 4 yr ; ( 2 ) 20 current asthmatics , and ( 3 ) 20 healthy young adults .", "entity": [{"entity": "IgE", "entity_type": "GENE", "pos": [66, 69]}], "task": "NER"}
{"text": "Continuous arterial blood sampling method based on the microsphere model was used as a quantitative rCBF measurement .", "entity": [], "task": "NER"}
{"text": "Members of the steroid / hormone nuclear receptor superfamily regulate target gene transcription via recognition and association with specific cis - acting sequences of DNA , called hormone response elements ( HREs ) .", "entity": [{"entity": "steroid / hormone nuclear receptor superfamily", "entity_type": "GENE", "pos": [15, 61]}], "task": "NER"}
{"text": "Thomas , S . S .", "entity": [], "task": "NER"}
{"text": "In addition to these cases , patients w with high Loa microfilaremia also developed milder neurologic manifestations causing functional impairment lasting for at least one week after treatment .", "entity": [], "task": "NER"}
{"text": "The patient demographics ( means + / - standard deviations ) were as follows : age , 57 + / - 12 years ; sex , nine males and three females ; APACHE II score , 15 + / - 3 ; diagnosis , 9 of 12 patients with pneumonia .", "entity": [], "task": "NER"}
{"text": "Patients with binocular pregeniculate visual loss , patients with balanced binocular pregeniculate loss without RAPD , and patients with monocular pregeniculate visual loss had significantly larger pupils than age - matched controls .", "entity": [], "task": "NER"}
{"text": "In contrast , corticotropin releasing factor ( CRF ) , injected centrally produces a suppression of punished and non - punished responding in the conflict test consistent with its hypothesized role in mediating behavioral responses to stress .", "entity": [{"entity": "corticotropin releasing factor", "entity_type": "GENE", "pos": [14, 44]}, {"entity": "CRF", "entity_type": "GENE", "pos": [47, 50]}], "task": "NER"}
{"text": "Analysis of replicative intermediates shows that plasmid YRp7 , which contains the chromosomal replicator ARS1 , initiates bidirectional replication in a 100 bp region within the sequence required for autonomous replication in vivo .", "entity": [], "task": "NER"}
{"text": "Tag expression induced apoptosis in mammary epithelial cells during late pregnancy .", "entity": [{"entity": "Tag", "entity_type": "GENE", "pos": [0, 3]}], "task": "NER"}
{"text": "Concentrations of Co , Cu , Fe , Hg , Mn , Sb , Se and Zn in IAEA milk ( dry ) standard A - 11 were re - evaluated with the help of instrumental and radiochemical neutron activation analysis ( NAA ) .", "entity": [], "task": "NER"}
{"text": "Here we show that these sequences are essential for processing of U18 and snR38 snoRNAs and that they compensate for the lack of a canonical terminal stem .", "entity": [{"entity": "U18", "entity_type": "GENE", "pos": [66, 69]}, {"entity": "snR38 snoRNAs", "entity_type": "GENE", "pos": [74, 87]}], "task": "NER"}
{"text": "In serum - starved NIH 3T3 cells , v - raf increased mdr1 promoter activity approximately 10 - fold compared to a v - raf frame - shift control .", "entity": [{"entity": "v - raf", "entity_type": "GENE", "pos": [35, 42]}, {"entity": "mdr1 promoter", "entity_type": "GENE", "pos": [53, 66]}, {"entity": "v - raf", "entity_type": "GENE", "pos": [114, 121]}], "task": "NER"}
{"text": "An insertion sequence element ( IS1170 ) was identified upstream of the nimC gene .", "entity": [{"entity": "nimC gene", "entity_type": "GENE", "pos": [72, 81]}], "task": "NER"}
{"text": "Two genes ( ptsI and ptsA ) that encode homologues of the energy coupling Enzyme I of the phosphoenolpyruvate - dependent sugar - transporting phosphotransferase system ( PTS ) have previously been identified on the Escherichia coli chromosome .", "entity": [{"entity": "ptsI", "entity_type": "GENE", "pos": [12, 16]}, {"entity": "ptsA", "entity_type": "GENE", "pos": [21, 25]}, {"entity": "Enzyme I", "entity_type": "GENE", "pos": [74, 82]}, {"entity": "phosphoenolpyruvate - dependent sugar - transporting phosphotransferase", "entity_type": "GENE", "pos": [90, 161]}], "task": "NER"}
{"text": "We show that the upstream region of the beta - MyHC gene ( - 5518 to - 2490 relative to the transcriptional start site ) directed high levels of transcriptional activity only when stably integrated , but not when expressed extrachromosomally in transient assays .", "entity": [{"entity": "beta - MyHC gene", "entity_type": "GENE", "pos": [40, 56]}], "task": "NER"}
{"text": "Although the cDNAs of HMG - 14 and HMG - 17 do not cross - hybridize , they have several similar structural features : the open reading frame comprises only 23 % of the transcripts , the 5 ' - untranslated region is extremely GC rich whereas the 3 ' - untranslated region is unusually long and AT rich .", "entity": [{"entity": "HMG - 14", "entity_type": "GENE", "pos": [22, 30]}, {"entity": "HMG - 17", "entity_type": "GENE", "pos": [35, 43]}], "task": "NER"}
{"text": "A minimal pheromone induction domain , delineated as residues 301 to 335 of Ste12p , is dependent on the pheromone mitogen - activated protein ( MAP ) kinase pathway for induction activity .", "entity": [{"entity": "Ste12p", "entity_type": "GENE", "pos": [76, 82]}, {"entity": "mitogen - activated protein ( MAP ) kinase", "entity_type": "GENE", "pos": [115, 157]}], "task": "NER"}
{"text": "The IFNAR chain interacts with both IFN - alpha 2 and IFN - beta , as demonstrated by cross - linking .", "entity": [{"entity": "IFNAR chain", "entity_type": "GENE", "pos": [4, 15]}, {"entity": "IFN - alpha 2", "entity_type": "GENE", "pos": [36, 49]}, {"entity": "IFN - beta", "entity_type": "GENE", "pos": [54, 64]}], "task": "NER"}
{"text": "To assess the effect on thrombus growth , we determined the accretion of 125I - labeled fibrinogen onto autologous non - radioactive thrombi preformed in the jugular veins of rabbits .", "entity": [{"entity": "fibrinogen", "entity_type": "GENE", "pos": [88, 98]}], "task": "NER"}
{"text": "In the other two cases , fluoxetine adjunct produced benefits with no additional side effects .", "entity": [], "task": "NER"}
{"text": "This radiolabeled , 900 - bp amplicon was used as a hybridization probe to screen a cDNA library constructed from poly ( A ) ( + ) RNA isolated from induced Taxus cells , from which a full - length transacetylase sequence was obtained .", "entity": [], "task": "NER"}
{"text": "Similarly , TAM - 67 reverted the morphology of the AdoMetDC - antisense expressors .", "entity": [{"entity": "TAM - 67", "entity_type": "GENE", "pos": [12, 20]}, {"entity": "AdoMetDC - antisense expressors", "entity_type": "GENE", "pos": [52, 83]}], "task": "NER"}
{"text": "For the second phase , it was 12 . 5 wk for RIR and 10 for WL males , whereas it was 5 wk for RIR and 6 for WL females .", "entity": [], "task": "NER"}
{"text": "TFEC RNA is found in many tissues of adult rats , but the relative concentrations of TFEC and TFE3 RNAs vary considerably in these different tissues .", "entity": [{"entity": "TFEC RNA", "entity_type": "GENE", "pos": [0, 8]}, {"entity": "TFEC", "entity_type": "GENE", "pos": [85, 89]}, {"entity": "TFE3 RNAs", "entity_type": "GENE", "pos": [94, 103]}], "task": "NER"}
{"text": "RESULTS : Three patients did not tolerate PPI medication and were managed by treatment with type 2 histamine ( H2 ) blockers .", "entity": [], "task": "NER"}
{"text": "VLA - 4 integrin cross - linking on human monocytic THP - 1 cells induces tissue factor expression by a mechanism involving mitogen - activated protein kinase .", "entity": [{"entity": "VLA - 4 integrin", "entity_type": "GENE", "pos": [0, 16]}, {"entity": "mitogen - activated protein kinase", "entity_type": "GENE", "pos": [124, 158]}], "task": "NER"}
{"text": "Diethyldithiocarbamate and amphetamine stereotype behavior .", "entity": [], "task": "NER"}
{"text": "Oct - 1 is a ubiquitously expressed regulatory gene of the POU domain family .", "entity": [{"entity": "Oct - 1", "entity_type": "GENE", "pos": [0, 7]}, {"entity": "POU domain family", "entity_type": "GENE", "pos": [59, 76]}], "task": "NER"}
{"text": "Both RNA14 and RNA15 wild - type genes , when cloned on a multicopy plasmid , are able to suppress the temperature - sensitive phenotype of strains bearing either the rna14 or the rna15 mutation , suggesting that the encoded proteins could interact with each other .", "entity": [{"entity": "RNA14", "entity_type": "GENE", "pos": [5, 10]}, {"entity": "RNA15 wild - type genes", "entity_type": "GENE", "pos": [15, 38]}, {"entity": "rna14", "entity_type": "GENE", "pos": [167, 172]}, {"entity": "rna15 mutation", "entity_type": "GENE", "pos": [180, 194]}], "task": "NER"}
{"text": "Recent studies have concentrated on the methods of preparation of coffee , which vary from country to country .", "entity": [], "task": "NER"}
{"text": "In addition , while GCN1 is required in vivo for phosphorylation of eIF - 2 alpha by GCN2 , cell extracts from gcn1 delta strains contained wild - type levels of GCN2 eIF - 2 alpha - kinase activity .", "entity": [{"entity": "GCN1", "entity_type": "GENE", "pos": [20, 24]}, {"entity": "eIF - 2 alpha", "entity_type": "GENE", "pos": [68, 81]}, {"entity": "GCN2", "entity_type": "GENE", "pos": [85, 89]}, {"entity": "gcn1 delta", "entity_type": "GENE", "pos": [111, 121]}, {"entity": "GCN2", "entity_type": "GENE", "pos": [162, 166]}, {"entity": "eIF - 2 alpha", "entity_type": "GENE", "pos": [167, 180]}], "task": "NER"}
{"text": "Seven patients were without a syndromic diagnosis .", "entity": [], "task": "NER"}
{"text": "Experimental production of a syndrome analogous to hydramnios in the rat fetus", "entity": [], "task": "NER"}
{"text": "The phP1 mutation was induced by insertion of a 1 . 2 - kb P element into the 5 ' transcribed nontranslated region of the proximal polyhomeotic gene .", "entity": [{"entity": "phP1", "entity_type": "GENE", "pos": [4, 8]}, {"entity": "P element", "entity_type": "GENE", "pos": [59, 68]}, {"entity": "polyhomeotic gene", "entity_type": "GENE", "pos": [131, 148]}], "task": "NER"}
{"text": "By contrast , clonidine ( 1 micrograms / kg ) elicited an immediate and prolonged fall in blood pressure and heart rate when given into the vertebral artery , but not intravenously .", "entity": [], "task": "NER"}
{"text": "Forty - eight pregnant adult and 122 fetal guinea pigs were sacrificed at intervals throughout gestation and the carcasses analyzed for a variety of growth parameters .", "entity": [], "task": "NER"}
{"text": "To investigate the in vivo role of this chimeric bZIP protein in oncogenic transformation , its expression was directed to the lymphoid compartments of transgenic mice .", "entity": [{"entity": "chimeric bZIP protein", "entity_type": "GENE", "pos": [40, 61]}], "task": "NER"}
{"text": "The MALDI - TOF experiment , however , proved to be superior to the GC experiment , particularly with regard to baseline resolution of unsaturated acids .", "entity": [], "task": "NER"}
{"text": "The mean serum CDT increased from 8 . 5 ( SD 2 . 2 ) U / l to 16 . 6 ( SD 7 . 2 ) U / l ( P < 0 . 001 ) .", "entity": [], "task": "NER"}
{"text": "In female toads , Bufo bufo , feeding at different rates , the uncorrected value of n was 0 . 44 , when metabolism and growth were expressed as kJ kJ - 1 .", "entity": [], "task": "NER"}
{"text": "In contrast , vRel lacks a strong C - terminal gene activation function , since a LexA fusion protein containing C - terminal vRel sequences alone only weakly activated transcription .", "entity": [{"entity": "vRel", "entity_type": "GENE", "pos": [14, 18]}, {"entity": "LexA fusion protein", "entity_type": "GENE", "pos": [82, 101]}, {"entity": "C - terminal vRel sequences", "entity_type": "GENE", "pos": [113, 140]}], "task": "NER"}
{"text": "Our study reveals a consequence of adhesion receptor - mediated signaling in T cells , which is potentially important in the regulation of T cell activation , including production of cytokines and expression of proto - oncogenes , many of which are controlled through 3 ' AU - rich elements .", "entity": [], "task": "NER"}
{"text": "Assessment of ammonia and urea blood content in metabolic acid - base disorders in white rats .", "entity": [], "task": "NER"}
{"text": "3 - 5 - fold increases in EGF receptor but not p185 ( neu ) tyrosine phosphorylation occur following Gi - coupled receptor stimulation .", "entity": [{"entity": "EGF receptor", "entity_type": "GENE", "pos": [26, 38]}, {"entity": "p185", "entity_type": "GENE", "pos": [47, 51]}, {"entity": "neu", "entity_type": "GENE", "pos": [54, 57]}, {"entity": "Gi - coupled receptor", "entity_type": "GENE", "pos": [101, 122]}], "task": "NER"}
{"text": "So it is sometimes more convenient to use the back Radon transform R - 1 and then to correct the result , taking into account attenuation .", "entity": [], "task": "NER"}
{"text": "Immune and clinical impact of Lactobacillus acidophilus on asthma .", "entity": [], "task": "NER"}
{"text": "These results indicate that ( 1 ) RXR - TR heterodimers play a role in basal transactivation and T3 suppression of negatively regulated genes , and ( 2 ) RXRs increase the dominant negative effect of some mutant TRs on specific negative TREs .", "entity": [{"entity": "RXR", "entity_type": "GENE", "pos": [34, 37]}, {"entity": "TR", "entity_type": "GENE", "pos": [40, 42]}, {"entity": "RXRs", "entity_type": "GENE", "pos": [154, 158]}, {"entity": "TRs", "entity_type": "GENE", "pos": [212, 215]}], "task": "NER"}
{"text": "Injections of PD solutions with 13 . 6 , 22 . 7 , and 38 . 6 g / liter of glucose reduced the ingestion of sucrose by 12 . 4 % , 23 . 6 % and 36 . 1 % , respectively , but did not affect the ingestion of protein .", "entity": [], "task": "NER"}
{"text": "To examine the functional relationship between distinct cis - active elements within the distal enhancer region of the rat PRL gene , we have used deletional and mutational analysis of that region in transient transfection studies in GH3 pituitary tumor cells .", "entity": [{"entity": "rat PRL gene", "entity_type": "GENE", "pos": [119, 131]}], "task": "NER"}
{"text": "While there is growing evidence that perception and imagery share common neural substrates , the fact that D . F . shows intact visual imagery in the face of a massive perceptual deficit in form vision challenges recent suggestions that these two psychological processes share common input pathways in early vision .", "entity": [], "task": "NER"}
{"text": "Site - directed mutagenesis of the conserved cysteine residue ( tom1C3235A ) in the hect - domain , supposed to be necessary for thioester - bond formation with ubiquitin , abolished the gene function .", "entity": [{"entity": "tom1C3235A", "entity_type": "GENE", "pos": [64, 74]}, {"entity": "hect - domain", "entity_type": "GENE", "pos": [84, 97]}, {"entity": "ubiquitin", "entity_type": "GENE", "pos": [161, 170]}], "task": "NER"}
{"text": "The Seldinger technique for difficult transurethral catheterization : a gentle alternative to suprapubic puncture ( Br J Surg 2000 ; 87 : 1729 - 30 ) .", "entity": [], "task": "NER"}
{"text": "Gingival retraction for class V restorations .", "entity": [], "task": "NER"}
{"text": "The amino acid sequence of the protein encoded by MSK1 is homologous to yeast cytoplasmic lysyl - tRNA synthetase and to the product of the herC gene , which has recently been suggested to code for the Escherichia coli enzyme .", "entity": [{"entity": "MSK1", "entity_type": "GENE", "pos": [50, 54]}, {"entity": "yeast cytoplasmic lysyl - tRNA synthetase", "entity_type": "GENE", "pos": [72, 113]}, {"entity": "herC gene", "entity_type": "GENE", "pos": [140, 149]}], "task": "NER"}
{"text": "In contrast to p62 ( dok ) , DOKL lacks YxxP motifs in the C terminus and does not bind to Ras GTPase - activating protein ( RasGAP ) upon phosphorylation .", "entity": [{"entity": "p62", "entity_type": "GENE", "pos": [15, 18]}, {"entity": "dok", "entity_type": "GENE", "pos": [21, 24]}, {"entity": "DOKL", "entity_type": "GENE", "pos": [29, 33]}, {"entity": "Ras GTPase - activating protein", "entity_type": "GENE", "pos": [91, 122]}, {"entity": "RasGAP", "entity_type": "GENE", "pos": [125, 131]}], "task": "NER"}
{"text": "The presence of chloroquine in saliva from seven healthy volunteers for 21 days after a single 600 mg oral dose of the drug was established by chromatographic and spectroscopic methods .", "entity": [], "task": "NER"}
{"text": "In vitro binding studies previously showed that NF - kappa B p50 homodimer binds the switch nuclear B - site protein ( SNIP ) of the S gamma 3 tandem repeat .", "entity": [{"entity": "NF - kappa B", "entity_type": "GENE", "pos": [48, 60]}, {"entity": "p50", "entity_type": "GENE", "pos": [61, 64]}, {"entity": "switch nuclear B - site protein", "entity_type": "GENE", "pos": [85, 116]}, {"entity": "SNIP", "entity_type": "GENE", "pos": [119, 123]}, {"entity": "S gamma 3 tandem repeat", "entity_type": "GENE", "pos": [133, 156]}], "task": "NER"}
{"text": "If , however , myocardial stunning is severe , and it involves large parts of the LV and thus impairs global LV function , it can be reversed with inotropic agents and procedures .", "entity": [], "task": "NER"}
{"text": "Similarly , interfering with MEKK , which lies upstream of JNK1 , using a dominant negative expression vector reduced MMP - 9 promoter activity over the same concentration range which repressed the AP - 1 - thymidine kinase CAT reporter construct .", "entity": [{"entity": "MEKK", "entity_type": "GENE", "pos": [29, 33]}, {"entity": "JNK1", "entity_type": "GENE", "pos": [59, 63]}, {"entity": "MMP - 9 promoter", "entity_type": "GENE", "pos": [118, 134]}, {"entity": "AP - 1", "entity_type": "GENE", "pos": [198, 204]}, {"entity": "thymidine kinase", "entity_type": "GENE", "pos": [207, 223]}, {"entity": "CAT", "entity_type": "GENE", "pos": [224, 227]}], "task": "NER"}
{"text": "The 7 . 2 kb EcoRI fragment of AfMNPV was cloned and the nucleotide sequences of the polyhedrin coding region and its flanking regions were determined .", "entity": [{"entity": "7 . 2 kb EcoRI fragment of AfMNPV", "entity_type": "GENE", "pos": [4, 37]}, {"entity": "polyhedrin", "entity_type": "GENE", "pos": [85, 95]}], "task": "NER"}
{"text": "Joint ultrasonography demonstrating thickening of synoviae and tendons has become a useful non - invasive diagnostic tool , although it is not specific for beta 2 - M amyloidosis , and results depend on observer experience .", "entity": [{"entity": "beta 2 - M", "entity_type": "GENE", "pos": [156, 166]}], "task": "NER"}
{"text": "Sequence analyses revealed a partial 941 bp cDNA that encoded a 313 - amino - acid polypeptide .", "entity": [], "task": "NER"}
{"text": "Estimating the health care costs of smokers .", "entity": [], "task": "NER"}
{"text": "Although paclitaxel alone failed to induce p38 MAPK activation , subsequent ( but not prior ) exposure to PD98059 induced a dramatic increase in p38 MAPK phosphorylation .", "entity": [{"entity": "p38", "entity_type": "GENE", "pos": [43, 46]}, {"entity": "p38", "entity_type": "GENE", "pos": [145, 148]}], "task": "NER"}
{"text": "The cyclin - dependent kinase Cdk2 associates with cyclins A , D , and E and has been implicated in the control of the G1 to S phase transition in mammals .", "entity": [{"entity": "cyclin - dependent kinase", "entity_type": "GENE", "pos": [4, 29]}, {"entity": "Cdk2", "entity_type": "GENE", "pos": [30, 34]}, {"entity": "cyclins A , D , and E", "entity_type": "GENE", "pos": [51, 72]}], "task": "NER"}
{"text": "Sequences within the UAS2 element of the ENO2 gene bound a second protein which corresponded to the ABFI ( autonomously replicating sequence - binding factor ) protein .", "entity": [{"entity": "ENO2 gene", "entity_type": "GENE", "pos": [41, 50]}, {"entity": "ABFI", "entity_type": "GENE", "pos": [100, 104]}, {"entity": "autonomously replicating sequence - binding factor", "entity_type": "GENE", "pos": [107, 157]}], "task": "NER"}
{"text": "Videoanalysis confirms the ballistic character of the initial phase of the reaching movement .", "entity": [], "task": "NER"}
{"text": "Toward this end , we used two cultured colon cancer cell lines ; one ( RKO ) has a transcriptionally activated u - PAR gene , and the other ( GEO ) overexpresses the receptor only after phorbol ester treatment .", "entity": [{"entity": "u - PAR gene", "entity_type": "GENE", "pos": [111, 123]}], "task": "NER"}
{"text": "Early detection and signs of hepatoangiosarcoma among vinyl chloride workers .", "entity": [], "task": "NER"}
{"text": "Many retroviruses , including the human and simian immunodeficiency viruses , contain a leucine zipper - like repeat in a highly conserved region of the external domain of the transmembrane ( TM ) glycoprotein .", "entity": [], "task": "NER"}
{"text": "Conversion of an NF - kappaB into a GABP binding site is likely to have occurred also during the worldwide spread of HIV - 1 , as we noticed the same LTR modification in subtype E isolates from Thailand .", "entity": [{"entity": "NF - kappaB", "entity_type": "GENE", "pos": [17, 28]}, {"entity": "GABP", "entity_type": "GENE", "pos": [36, 40]}], "task": "NER"}
{"text": "Bedbug ( Cimex lectularius ) samples adult and nymphs either engorged or starved from Central Security Forces sleeping wards , laboratory animal house and control samples from laboratory reared colonies were ground and subjected to ELISA test of hepatitis B surface antigen together with 276 serum samples from the recruits slept in those wards .", "entity": [{"entity": "hepatitis B surface antigen", "entity_type": "GENE", "pos": [246, 273]}], "task": "NER"}
{"text": "Ciprofloxacin attained a peak serum concentration of 1 . 2 mg / l and a serum half - life of 34 min .", "entity": [], "task": "NER"}
{"text": "As usual tests , such as \" time \" of cephalin are slightly sensible to LMW - Hep , only anti - Xa activity can be used .", "entity": [], "task": "NER"}
{"text": "Although they are similar to the IL9R gene ( approximately 90 % identity ) , none of these copies encodes a functional receptor : none of them contains sequences homologous to the 5 ' flanking region or exon 1 of the IL9R gene , and the remaining ORFs have been inactivated by various point mutations and deletions .", "entity": [{"entity": "IL9R gene", "entity_type": "GENE", "pos": [33, 42]}, {"entity": "IL9R gene", "entity_type": "GENE", "pos": [217, 226]}], "task": "NER"}
{"text": "In two patients , a male homosexual and an hemophiliac , thrombocytopenia was associated with AIDS - related complex .", "entity": [], "task": "NER"}
{"text": "Choline acetyltransferase immunohistochemistry combined with the retrograde transport of horseradish peroxidase showed that the reticular and mediodorsal thalamic nuclei of the cat receive an important input from cholinergic and non - cholinergic neurons of substantia innominata and adjacent structures in the basal forebrain .", "entity": [{"entity": "Choline acetyltransferase", "entity_type": "GENE", "pos": [0, 25]}, {"entity": "horseradish peroxidase", "entity_type": "GENE", "pos": [89, 111]}], "task": "NER"}
{"text": "Mortality among patients with CAVB is still high and has not declined within the last decade .", "entity": [], "task": "NER"}
{"text": "We conclude that in the presence of fatty acids in the medium transcription of SPS19 is directly regulated by both Pip2p - Oaf1p and Adr1p .", "entity": [{"entity": "SPS19", "entity_type": "GENE", "pos": [79, 84]}, {"entity": "Pip2p", "entity_type": "GENE", "pos": [115, 120]}, {"entity": "Oaf1p", "entity_type": "GENE", "pos": [123, 128]}, {"entity": "Adr1p", "entity_type": "GENE", "pos": [133, 138]}], "task": "NER"}
{"text": "The purified RAG1 protein overexpressed in E . coli exhibited the expected cleavage activity when combined with RAG2 purified from transfected 293T cells .", "entity": [{"entity": "RAG1 protein", "entity_type": "GENE", "pos": [13, 25]}, {"entity": "RAG2", "entity_type": "GENE", "pos": [112, 116]}], "task": "NER"}
{"text": "Serum triglycerides also showed an increase from birth to 6 months of age , but a decrease from 6 months to 1 years of age .", "entity": [], "task": "NER"}
{"text": "These mutant rps7 leaders were ligated into an aadA expression cassette and transformed into the chloroplast of C . reinhardtii and into E . coli .", "entity": [{"entity": "mutant rps7", "entity_type": "GENE", "pos": [6, 17]}], "task": "NER"}
{"text": "The use of medication is of minor importance in the treatment of flight phobia .", "entity": [], "task": "NER"}
{"text": "We previously described the upregulation of the MT2 antigen during urodele limb regeneration and characterized the MT2 antigen as a 310 - to 325 - kDa chondroitin - sulfated glycoprotein with a core protein of 285 - 300 kDa .", "entity": [{"entity": "MT2 antigen", "entity_type": "GENE", "pos": [48, 59]}, {"entity": "MT2 antigen", "entity_type": "GENE", "pos": [115, 126]}], "task": "NER"}
{"text": "Southern blot analysis following reverse transcription and PCR showed that B2R is expressed in most mouse tissues , except the liver and spleen , which is consistent with the wide distribution of B2R activity as deduced from pharmacological studies .", "entity": [{"entity": "B2R", "entity_type": "GENE", "pos": [75, 78]}, {"entity": "B2R", "entity_type": "GENE", "pos": [196, 199]}], "task": "NER"}
{"text": "The dynamics of N - interaction and N - retention during 3 hr CPB was quantified with autologous In - 111 labeled neutrophils ( INN ) in 4 groups of 20 Yorkshire pigs ( 28 - 35 kg , 5 sham ; 5 CPB , 1 hr ; 5 CPB , 3 hr and 5 CPB with heparinized circuit , 3 hr ) ; anesthetized pigs were injected with INN ( 500 - 650 microCi ) , 30 min before CPB and heparinized , and underwent CPB with a roller pump , a hollow fiber OX ( Bentley CM 50 , 5 . 0 m2 ) and AF ( Bentley AF 025 , 0 . 25 m2 ) at 2 . 5 - 3 . 6 l / min for 3 hr .", "entity": [], "task": "NER"}
{"text": "The effect of the negative regulatory element is negated by the viral IE2 protein ( L .", "entity": [{"entity": "viral IE2 protein", "entity_type": "GENE", "pos": [64, 81]}], "task": "NER"}
{"text": "Cloning of the GATA - binding protein that regulates endothelin - 1 gene expression in endothelial cells .", "entity": [{"entity": "GATA - binding protein", "entity_type": "GENE", "pos": [15, 37]}, {"entity": "endothelin - 1 gene", "entity_type": "GENE", "pos": [53, 72]}], "task": "NER"}
{"text": "John ' s wort", "entity": [], "task": "NER"}
{"text": "In contrast SF , but not GM - CSF or IL - 3 , induced tyrosine phosphorylation of phospholipase C - gamma ( PLC - gamma ) .", "entity": [{"entity": "SF", "entity_type": "GENE", "pos": [12, 14]}, {"entity": "GM - CSF", "entity_type": "GENE", "pos": [25, 33]}, {"entity": "IL - 3", "entity_type": "GENE", "pos": [37, 43]}, {"entity": "phospholipase C - gamma", "entity_type": "GENE", "pos": [82, 105]}, {"entity": "PLC - gamma", "entity_type": "GENE", "pos": [108, 119]}], "task": "NER"}
{"text": "Using the interaction - trap assay to identify candidate proteins that bind the cytoplasmic region of the LAR transmembrane protein tyrosine phosphatase ( PT - Pase ) , we isolated a cDNA encoding a 2861 - amino acid protein termed Trio that contains three enzyme domains : two functional GEF domains and a protein serine / threonine kinase ( PSK ) domain .", "entity": [{"entity": "LAR transmembrane protein tyrosine phosphatase", "entity_type": "GENE", "pos": [106, 152]}, {"entity": "PT - Pase", "entity_type": "GENE", "pos": [155, 164]}, {"entity": "Trio", "entity_type": "GENE", "pos": [232, 236]}, {"entity": "GEF domains", "entity_type": "GENE", "pos": [289, 300]}, {"entity": "protein serine / threonine kinase", "entity_type": "GENE", "pos": [307, 340]}, {"entity": "PSK", "entity_type": "GENE", "pos": [343, 346]}], "task": "NER"}
{"text": "The role of the putative C2 domain of Nedd4 has not been elucidated .", "entity": [{"entity": "C2", "entity_type": "GENE", "pos": [25, 27]}, {"entity": "Nedd4", "entity_type": "GENE", "pos": [38, 43]}], "task": "NER"}
{"text": "The effect on FIV LTR promoter activity of progressively deleting these nuclear factor binding sites was examined by linking LTR deletion mutants to the chloramphenicol acetyltransferase ( CAT ) gene .", "entity": [{"entity": "FIV LTR promoter", "entity_type": "GENE", "pos": [14, 30]}, {"entity": "chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [153, 186]}, {"entity": "CAT", "entity_type": "GENE", "pos": [189, 192]}], "task": "NER"}
{"text": "Additionally , these findings have important implications for the understanding of the mechanisms of HIV - 1 latency and reactivation .", "entity": [], "task": "NER"}
{"text": "Furthermore , we show that Nck - 2 is capable of recognizing several key components of growth factor receptor kinase - signaling pathways including EGF receptors , PDGF receptor - beta , and IRS - 1 .", "entity": [{"entity": "Nck - 2", "entity_type": "GENE", "pos": [27, 34]}, {"entity": "growth factor receptor kinase", "entity_type": "GENE", "pos": [87, 116]}, {"entity": "EGF receptors", "entity_type": "GENE", "pos": [148, 161]}, {"entity": "PDGF receptor - beta", "entity_type": "GENE", "pos": [164, 184]}, {"entity": "IRS - 1", "entity_type": "GENE", "pos": [191, 198]}], "task": "NER"}
{"text": "The average mean difference compared with the low and the intermediate calcium group was 11 % for the femoral neck , 8 - 11 % for the lumbar spine and 5 - 6 % for total body BMDs .", "entity": [], "task": "NER"}
{"text": "Although the number of kits has increased , the precision has improved , showing that more robust methods are now employed .", "entity": [], "task": "NER"}
{"text": "The predicted amino acid sequence contained all consensus regions for S - adenosyl methionine methyltransferases and presented 26 % identity with Saccharomyces cerevisiae DHHB - methyltransferase and 38 % identity with the rat protein , as well as with a bacterial ( Escherichia coli and Salmonella typhimurium ) methyltransferase encoded by the UBIG gene .", "entity": [{"entity": "S - adenosyl methionine methyltransferases", "entity_type": "GENE", "pos": [70, 112]}, {"entity": "Saccharomyces cerevisiae DHHB - methyltransferase", "entity_type": "GENE", "pos": [146, 195]}, {"entity": "methyltransferase", "entity_type": "GENE", "pos": [313, 330]}, {"entity": "UBIG gene", "entity_type": "GENE", "pos": [346, 355]}], "task": "NER"}
{"text": "To investigate its transcription , 1 . 1 kilobases of the 5 ' - flanking sequence were fused to a luciferase reporter gene .", "entity": [{"entity": "luciferase reporter gene", "entity_type": "GENE", "pos": [98, 122]}], "task": "NER"}
{"text": "A selective transcriptional induction system for mammalian cells based on Gal4 - estrogen receptor fusion proteins .", "entity": [{"entity": "Gal4", "entity_type": "GENE", "pos": [74, 78]}, {"entity": "estrogen receptor", "entity_type": "GENE", "pos": [81, 98]}], "task": "NER"}
{"text": "PATIENT ( S ) : Two hundred thirty - eight patients with RPLs , 48 patients with recurrent IVF - ET failure and 179 nonpregnant and 120 pregnant control group women .", "entity": [], "task": "NER"}
{"text": "The effects of oxalate - containing products on the exposed dentine surface : an SEM investigation .", "entity": [], "task": "NER"}
{"text": "The cyanobacterial phycobilisome is a large protein complex located on the photosynthetic membrane .", "entity": [{"entity": "cyanobacterial phycobilisome", "entity_type": "GENE", "pos": [4, 32]}], "task": "NER"}
{"text": "Up to 1988 , 145 cases had been reported in literature and 32 cases in our country .", "entity": [], "task": "NER"}
{"text": "Lamivudine therapy for acute hepatitis B infection following peripheral blood stem cell transplantation .", "entity": [], "task": "NER"}
{"text": "Disorganization scores of the hypertrophy zone and trabecular bone were low , approaching normal ( P < 0 . 05 ) , for turkey poults fed on diets with phytase supplementation , and tibial abnormality scores were linearly decreased ( P < 0 . 001 ) as nP levels increased ( zero score is considered normal ) .", "entity": [{"entity": "phytase", "entity_type": "GENE", "pos": [150, 157]}], "task": "NER"}
{"text": "The collicular labels found after injections within the MST area exhibited their distribution over the deep SC subdivision , whereas they spared all the superficial layers but the deep part of the SO .", "entity": [], "task": "NER"}
{"text": "Modern aspects of shock - treatment in extensive burns ( author ' s transl )", "entity": [], "task": "NER"}
{"text": "UVB - induced association of tumor necrosis factor ( TNF ) receptor 1 / TNF receptor - associated factor - 2 mediates activation of Rel proteins .", "entity": [{"entity": "tumor necrosis factor ( TNF ) receptor 1", "entity_type": "GENE", "pos": [29, 69]}, {"entity": "TNF receptor - associated factor - 2", "entity_type": "GENE", "pos": [72, 108]}, {"entity": "Rel proteins", "entity_type": "GENE", "pos": [132, 144]}], "task": "NER"}
{"text": "Mapping of the region in KAP - 1 required for HP1 interaction showed that amino acid substitutions which abolish HP1 binding in vitro reduce KAP - 1 mediated repression in vivo .", "entity": [{"entity": "KAP - 1", "entity_type": "GENE", "pos": [25, 32]}, {"entity": "HP1", "entity_type": "GENE", "pos": [46, 49]}, {"entity": "HP1", "entity_type": "GENE", "pos": [113, 116]}, {"entity": "KAP - 1", "entity_type": "GENE", "pos": [141, 148]}], "task": "NER"}
{"text": "However , whether this was associated with spleen removal after adjustment for risk factors was not determined .", "entity": [], "task": "NER"}
{"text": "Taken together , these data suggest that the Smad3 / Smad4 complex has at least two separable nuclear functions : it forms a rapid , yet transient sequence - specific DNA binding complex , and it potentiates AP1 - dependent transcriptional activation .", "entity": [{"entity": "Smad3", "entity_type": "GENE", "pos": [45, 50]}, {"entity": "Smad4", "entity_type": "GENE", "pos": [53, 58]}, {"entity": "AP1", "entity_type": "GENE", "pos": [208, 211]}], "task": "NER"}
{"text": "However , one activity binds preferentially to G + C - rich promoters , and another activity appears to bind preferentially to only two of the promoters tested .", "entity": [], "task": "NER"}
{"text": "The donors of 10 patients were ABO - incompatible , and for five pairs the ABO incompatibility was major .", "entity": [], "task": "NER"}
{"text": "In treatments R1 and R2 , feed quality was restricted by withholding concentrates for 3 and 4 . 5 mo , respectively .", "entity": [], "task": "NER"}
{"text": "The major promoter element of the Xenopus laevis 5S RNA gene is located within the transcribed region of the gene and forms the binding site for the transcription initiation factor TFIIIA .", "entity": [{"entity": "Xenopus laevis 5S RNA gene", "entity_type": "GENE", "pos": [34, 60]}, {"entity": "TFIIIA", "entity_type": "GENE", "pos": [181, 187]}], "task": "NER"}
{"text": "However , in transient transfection assays , a truncation of as little as 15 Nurr1 COOH - terminal amino acids diminished transcriptional activation of B1A - thymidine kinase - chloramphenicol acetyltransferase reporter .", "entity": [{"entity": "Nurr1", "entity_type": "GENE", "pos": [77, 82]}, {"entity": "B1A", "entity_type": "GENE", "pos": [152, 155]}, {"entity": "thymidine kinase", "entity_type": "GENE", "pos": [158, 174]}, {"entity": "chloramphenicol acetyltransferase", "entity_type": "GENE", "pos": [177, 210]}], "task": "NER"}
{"text": "Small cell tumors in children : contribution to the solution of the problem of differential diagnosis with immunohistochemistry and electron microscopy", "entity": [], "task": "NER"}
{"text": "Four experiments examined the role of the cholinergic projections from the septum and vertical limb nucleus of the diagonal band of Broca ( VDB ) in acquisition and performance of a conditional visual discrimination .", "entity": [], "task": "NER"}
{"text": "Deletion of this consensus element from the spo6 promoter abolished the transcription of spo6 + and resulted in a sporulation deficiency .", "entity": [{"entity": "spo6 promoter", "entity_type": "GENE", "pos": [44, 57]}, {"entity": "spo6 +", "entity_type": "GENE", "pos": [89, 95]}], "task": "NER"}
{"text": "This region does not contain a consensus estrogen response element , and ER binding to this DNA sequence was not observed .", "entity": [{"entity": "ER", "entity_type": "GENE", "pos": [73, 75]}], "task": "NER"}
{"text": "We have previously reported that analgesic doses of morphine accelerate mortality of rats exposed to hemorrhage ( Feuerstein and Siren : Circ Shock 19 : 293 - 300 , 1986 ) .", "entity": [], "task": "NER"}
{"text": "Microsporum persicolor , an easily misinterpreted dermatophyt", "entity": [], "task": "NER"}
{"text": "When they were exposed to intermittent schedules of punishment ( fixed - interval [ FI ] 120 s or FI 300 s ) , SIB for all but 1 of the participants increased to levels similar to those observed during baseline .", "entity": [], "task": "NER"}
{"text": "These results suggest that 1a , which also interacts independently with the ER and viral RNA , is a key organizer of RNA replication complex assembly .", "entity": [{"entity": "1a", "entity_type": "GENE", "pos": [27, 29]}], "task": "NER"}
{"text": "Here we examine the population of gammaS transcripts in adult human lens and the structure of the human CRYGS genes .", "entity": [{"entity": "gammaS transcripts", "entity_type": "GENE", "pos": [34, 52]}, {"entity": "human CRYGS genes", "entity_type": "GENE", "pos": [98, 115]}], "task": "NER"}
{"text": "PKK exists in three discernible forms at steady state : an underphosphorylated form of 100 kDa ; a soluble , cytosolic , phosphorylated form of 110 kDa ; and a phosphorylated , detergent - insoluble form of 112 kDa .", "entity": [{"entity": "PKK", "entity_type": "GENE", "pos": [0, 3]}], "task": "NER"}
{"text": "The lamina densa was always interrupted by numerous small gaps and in some areas the basement membrane could not be identified over a long distance .", "entity": [], "task": "NER"}
{"text": "The human CA11 gene appears to be located between the secretor type alpha ( 1 , 2 ) - fucosyltransferase gene cluster ( FUT1 - FUT2 - FUT2P ) and the D - site binding protein gene ( DBP ) on chromosome 19q13 . 3 .", "entity": [{"entity": "human CA11 gene", "entity_type": "GENE", "pos": [4, 19]}, {"entity": "secretor type alpha ( 1 , 2 ) - fucosyltransferase gene cluster", "entity_type": "GENE", "pos": [54, 117]}, {"entity": "FUT1", "entity_type": "GENE", "pos": [120, 124]}, {"entity": "FUT2", "entity_type": "GENE", "pos": [127, 131]}, {"entity": "FUT2P", "entity_type": "GENE", "pos": [134, 139]}, {"entity": "D - site binding protein gene", "entity_type": "GENE", "pos": [150, 179]}, {"entity": "DBP", "entity_type": "GENE", "pos": [182, 185]}], "task": "NER"}
{"text": "A score ( APACHE II ) was calculated to assess the severity of disease .", "entity": [], "task": "NER"}
{"text": "To determine the role of elevated FAK expression in facilitating epidermal growth factor ( EGF ) - stimulated human adenocarcinoma ( A549 ) cell motility , antisense oligonucleotides were used to reduce FAK protein expression > 75 % .", "entity": [{"entity": "FAK", "entity_type": "GENE", "pos": [34, 37]}, {"entity": "epidermal growth factor", "entity_type": "GENE", "pos": [65, 88]}, {"entity": "EGF", "entity_type": "GENE", "pos": [91, 94]}, {"entity": "FAK protein", "entity_type": "GENE", "pos": [203, 214]}], "task": "NER"}
{"text": "Evaluation of materials and technics in vascular surgery using 111 - Indium", "entity": [], "task": "NER"}
{"text": "Functional importance of a properly folded surface loop covering the catalytic center .", "entity": [], "task": "NER"}
{"text": "Hypoxia decreased the rate of spontaneous impulse initiation in SA nodal fibers by decreasing the slope of diastolic depolarization .", "entity": [], "task": "NER"}
{"text": "Radiative corrections to pi l2 decays .", "entity": [], "task": "NER"}
{"text": "The availability of a commercial program ( PCNONLIN ) is needed to carry out matrix handling calculations .", "entity": [], "task": "NER"}
{"text": "The levels of TPAR1 mRNAs were dramatically down - regulated in regenerating rat liver when compared to normal adult liver .", "entity": [{"entity": "TPAR1 mRNAs", "entity_type": "GENE", "pos": [14, 25]}], "task": "NER"}
{"text": "In the postoperative patient with tetralogy of Fallot with symptomatic ventricular arrhythmias , it is concluded that electrophysiologic study is useful in reproducing clinical episodes of VT and in selecting effective antiarrhythmic medication ; a small number of patients with ventricular premature complexes alone will have inducible sustained VT during electrophysiologic study ; prognosis of these patients may be improved by treatment that results in prevention of VT induction ; and in patients with right ventricular hypertension , VT is likely to be refractory to drug treatment .", "entity": [], "task": "NER"}
{"text": "Hip fracture mortality and prospective payment system .", "entity": [], "task": "NER"}
{"text": "Primary care programs for the indigent .", "entity": [], "task": "NER"}
{"text": "In human myxoid liposarcoma , a chromosomal rearrangement leads to fusion of the growth - arresting and DNA - damage - inducible transcription factor CHOP ( GADD153 ) to a peptide fragment encoded by the TLS gene .", "entity": [{"entity": "CHOP", "entity_type": "GENE", "pos": [150, 154]}, {"entity": "GADD153", "entity_type": "GENE", "pos": [157, 164]}, {"entity": "TLS gene", "entity_type": "GENE", "pos": [204, 212]}], "task": "NER"}
{"text": "Categorisation of the different substructures within the sections allows them to be analysed and displayed separately .", "entity": [], "task": "NER"}
{"text": "Authors present the anatomical variations of the course of the inferior mesenteric artery and its branches in 62 human fetus .", "entity": [], "task": "NER"}
{"text": "This mechanism seems to be involved in VIP - induced PRL gene regulation .", "entity": [{"entity": "VIP", "entity_type": "GENE", "pos": [39, 42]}, {"entity": "PRL gene", "entity_type": "GENE", "pos": [53, 61]}], "task": "NER"}
{"text": "The only quantities which were significantly different between appendicitis and a normal appendix were sex , duration of symptoms , anorexia and vomiting .", "entity": [], "task": "NER"}
{"text": "Signaling through mitogen - activated protein kinase and Rac / Rho does not duplicate the effects of activated Ras on skeletal myogenesis .", "entity": [{"entity": "mitogen - activated protein kinase", "entity_type": "GENE", "pos": [18, 52]}, {"entity": "Rac", "entity_type": "GENE", "pos": [57, 60]}, {"entity": "Rho", "entity_type": "GENE", "pos": [63, 66]}, {"entity": "Ras", "entity_type": "GENE", "pos": [111, 114]}], "task": "NER"}
{"text": "The survival of patients with a short bowel , even if they need long - term parenteral nutrition , is good .", "entity": [], "task": "NER"}
{"text": "Unlike these contaminant - responsive T cells , those that are truly specific for natural AChR epitopes appear less heterogeneous and therefore more suitable targets for selective immunotherapy .", "entity": [{"entity": "AChR epitopes", "entity_type": "GENE", "pos": [90, 103]}], "task": "NER"}
{"text": "CONCLUSIONS : This initial experience indicates that there is short - to middle - term efficiency and safety when using GKS to treat MTLE .", "entity": [], "task": "NER"}
{"text": "A Brassica cDNA clone encoding a bifunctional hydroxymethylpyrimidine kinase / thiamin - phosphate pyrophosphorylase involved in thiamin biosynthesis .", "entity": [{"entity": "hydroxymethylpyrimidine kinase", "entity_type": "GENE", "pos": [46, 76]}, {"entity": "thiamin - phosphate pyrophosphorylase", "entity_type": "GENE", "pos": [79, 116]}], "task": "NER"}
{"text": "The aims of this study were to examine whether the EORTC ( European Organisation for Research and Treatment of Cancer ) QLQ - C30 core questionnaire alone could distinguish between two clinically different groups of patients and to design a module , which included relevant patient - defined gastric cancer - specific variables .", "entity": [], "task": "NER"}
{"text": "The goal of our work was to determine hearing thresholds in patients with hearing impairment due to hereditary motor and sensory neuropathy ( HMSN I ) .", "entity": [], "task": "NER"}
{"text": "Causal modeling combines theory and research , and because the interpretation of data is possible only within the context of the proposed theory , it offers an important method for advancing the science while maintaining the specificity of the practice .", "entity": [], "task": "NER"}