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+LD(50) is 1.1 ug/g in Blattella germanica
+LD(50) is 2 mg/kg by intravenous injection into mouse
+LD(50) is 15.4 ug/ml against the brine shrimp A.salina
+LD(50) is 6 ug/g by injection
+PD(50) is 215 ug/kg to crabs. LD(50) is >1000 ug/kg to crabs
+LD(100) is 10 ug/g on the shrimp C.multidentata
+LD(50) is 0.08 mg/kg by intraperitoneal injection
+LD(50) is 0.06 ug/kg by intracerebroventricular injection into mice
+LD(50) is 0.2 mg/kg by subcutaneous injection into mice
+LD(50) is 770 pmol/g when injected into crickets
+PD(50) is 200 +-36 pmol/g when injected into crickets
+PD(50) is 54 +- 14 pmol/g when injected into blowfly larvae
+PD(50) is 291 pmol/g of crickets
+LD(50) is 1 ug/kg by intramuscular injection into crabs (C.maenas)
+LD(50) is 110 ug/kg by intraperitoneal injection into mice
+Intrathoracical injection into juvenile crickets (Gryllus bimaculatus) of this toxin (at a dose of ca. 1100 pmol/g (4 ug/g)) causes a rapid insecticidal activity, with complete paralysis within 5 minutes and death within 15 minutes
+Intracerebroventricular injection into mice of this toxin (at a dose of 1.8 ug per mice) causes strong neurotoxicity symptoms, including convulsions, tonic paralysis, general ataxia, extension of legs and toes, tail erection, and respiratory paralysis resulting in very marked cyanosis of the animal. These symptoms are reversible
+LD(50) is 0.19 ug/ml against killifish
+On fish, this toxin causes paralysis and death on intramuscular injection at doses of approximately 20 pmol/g. On intracranial injection into mice, it causes respiratory distress at around 70 pmol/g mouse and is lethal at around 300 pmol/g mouse
+LD(50) is 1.34 mg/kg by intravenous injection into mice (in Amami-Oshima and Tokunoshima strains)
+LD(50) is 0.14 mg/kg by intraperitoneal injection in mice
+LD(50) is >50 ug/g in S.carnaria larvae
+PD(50) is 33-50 ug/g in S.carnaria larvae
+PD(50) of HwTx-V is 16 +/- 5 mg/kg to locusts
+LD(50) is 10 ug/kg by intracerebroventricular injection into mice
+LD(50) is 750 ug/kg intraperitoneal injection into mice
+PD(50) is 76 nmol/kg into blowfly larvae
+PD(50) is 0.84 +- 0.16 ug/g body weight when injected into the shrimp P.paucidens. The minimum paralytic dose is 2 ug/g body weight shrimp body weight
+LD(50) is 0.088 ug/g by subcutaneous injection into mice, 0.0023 ug/g by intracerebroventricular injection into mice and 14.3 ug/g in B.germanica
+LD(50) is 10.7 mg/kg by intraperitoneal injection into mice
+LD(50) is 34.3 nmol/kg to cockroaches (Blattella germanica)
+LD(50) is 23 ug/kg by intravenous injection into mice
+LD(50) is 5 ug/kg in adult cockroaches
+LD(50) is 7.6 ug/kg in mealbeetles
+LD(50) is 250 ug/kg by subcutaneous injection to mice
+LD(50) is 0.3 ug/ml against vascular endothelial cells in culture
+LD(50) is 5.8 mg/kg by subcutaneous administration into mice
+LD(50) is 23 +/- 3 mg/kg by intravenous injection
+LD(50) is 144.4 nmol/kg by intramuscular injection within 1 hr
+LD(50) is 7.0 mg/kg by intraperitoneal injection into mice
+In monomer CBa2, LD(50) is 700 ug/kg by intravenous injection into mice
+In monomer CBa2, LD(50) is >3000 ug/kg by subcutaneous injection into mice
+In class 2 heterodimer CA2-CBa2, LD(50) is 420 ug/kg by intravenous injection into mice
+In class 2 heterodimer CA2-CBa2, LD(50) is 650 ug/kg by subcutaneous injection into mice
+In class 2 heterodimer CA3-CBa2, LD(50) is 450 ug/kg by intravenous injection into mice
+LD(50) is 60 mg/kg by subcutaneous injection
+LD(50) is 0.15 mg/kg by intramuscular injection into mice
+LD(50) is 5 ug/g on adult flesh flies (S.carnaria) (PubMed:18215128)
+LD(50) is 20 ug/g on flesh fly larvae (S.carnaria) (PubMed:18215128)
+LD(50) is 500 ug/g on cockroachs (N.cinerea) (PubMed:18215128)
+LD(50) is 12.3 ug/g on D.melanogaster (PubMed:27287558)
+LD(50) is 75 ug/g in larvae of flesh fly S.carnaria
+LD(50) is 0.18 mg/kg by intravenous injection into mice
+LD(50)is 20 ug/kg by subcutaneous injection into mice
+LD(50) is 4.2 ug/g by intravenous injection into mice
+LD(50) is 1.41 mg/kg by intracerebroventricular injection into mice
+PD(50) is 16 mg/kg in cockroaches
+Monomer (alpha chain): LD(50) is 0.3 mg/kg by intravenous injection into mice
+Heterotrimer: LD(50) is 2 ug/kg by intravenous injection into mice
+LD(50) is 0.3 ug/kg by intrahemocoelic injection
+LD(50) is 0.35 mg/kg by intraperitoneal injection into mice (PubMed:363352). LD(50) is 4 mg/kg by intravenous injection into rats, and 0.1 mg/kg by intravenous injection into dogs (PubMed:363352). LD(50) is 2 ug/kg by intracerebroventricular injection into mice, and 10 ug/kg by intracerebroventricular injection into rats (PubMed:363352)
+LD(50) is 0.12 mg/kg by intramuscular injection into mice
+LD(100) is 200 ug/g when the recombinant non-amidated toxin is tested on larvae of the housefly Musca domestica
+LD(50) is 5 mg/kg by intravenous injection into mice
+LD(50) is 2.9 mg/kg by subcutaneous injection into mice
+LD(50) is 1 mg/kg by intravenous injection into mice
+LD(50) is 0.75 mg/kg by intravenous injection into mice
+LD(50) is 0.53 mg/kg by intravenous injection into tail mice
+LD(50) is 2.77 ug/ml against the brine shrimp A.salina
+LD(50) is 0.3467 mg/kg by intraperitoneal injection into mice
+LD(50) is 28.5 mg/g body weight of crayfish
+LD(50) is 20 ng/house fly
+LD(50) is 80 ng/100 mg of body weight cockroach larvae (B.germanica)
+LD(50) is 200-250 ug/kg by intraperitoneal injection into mice
+LD(50) is 0.067 mg/kg by intramuscular injection into mice
+LD(50) is 14 pg (98 amol) per Aedes 3rd instar larve when injected directly between the head and thorax
+LD(50) is 6.5 pg (44.5 amol) per Anopheles 3rd instar larve when injected directly between the head and thorax
+PD(50) is 10.27 nmol/g when injected into D.melanogaster
+LD(50) is 0.9 mg/kg by intraperitoneal injection
+LD(50) is 8 mg/kg by subcutaneous injection
+LD(50) is 1.97 mg/kg by intravenous injection
+LD(50) is 70 ug/kg by intraperitoneal injection into mice
+LD(50) is 45 ug/g in flesh fly larvae (S.carnaria)
+LD(50) is 45 ug/g in house crickets (Acheta domesticus)
+LD(50) is 1.8 mg/kg by intravenous injection into mice
+LD(50) is 6.8 mg/kg by intravenous injection
+LD(50) is 0.2 +-0.07 mg/kg by intraperitoneal injection into mice
+LD(50) is 0.086 mg/kg by intraperitoneal injection
+LD(50) is 1.96 mg/kg by intravenous injection
+LD(50) is 0.125 mg/kg by intravenous injection
+LD(50) is 0.4 mg/kg by subcutaneous injection
+LD(50) is 784 pmol/g of when injected into mealworm, LD(50) is 1284 pmol/g of when injected into cricket, LD(50) is 4382 pmol/g of when injected into blowfly larvae, LD(50) is 4995 pmol/g of when injected into blowfly adult
+LD(50) is 0.38 mg/kg by subcutaneous injection
+LD(50) is 13.4 mg/kg by subcutaneous injection
+LD(50) is 7 mg/kg by intravenous injection into mice
+LD(50) is 0.55 mg/kg by intraperitoneal injection into geckos
+LD(50) is 0.22 mg/kg by intraperitoneal injection into chicks
+LD(50) is 16.6 mg/kg by intravenous injection
+LD(50) is 0.63 mg/kg by intravenous injection
+PD(50) is 3.70 +/- 0.19 mg/kg by injection into the abdomen of larvae of H.virescens
+LD(50) is 0.83 mg/kg by intravenous injection
+PD(50) is 11.0 mg/kg of insects (crickets)
+PD(50) is 0.49 ng/mg in Gryllus bimaculatus crickets
+LD(50) is 4.75 ug/ml against the brine shrimp A.salina
+LD(50) is 25.5 ug/ml against the aquatic snail B.glabrata
+LD(50) is 67 ng/100 mg of body weight of blowfly larvae (S.falculata) and 138 ng/100 mg of body weight of cockroaches (B.germanica)
+LD(50) is 10 mg/kg by intravenous injection
+10 ug of this toxin kills a mouse of 20g body weight within 20 minutes after intraperitoneal injection
+LD(50) is 0.22 mg/kg by intravenous injection
+LD(50) is 400 mg/kg body weight in male mice and 600 mg/kg in female mice (intravenous). From the autopsies of test mice, hepatic congestion is found in dead mice, but the organs of surviving mice lacked any other abnormal indications
+In monomer B, LD(50) is 0.49 ug/g by intravenous injection into mice. Toxicity is higher in combination with subunit A
+In heterodimer A-B, LD(50) is 0.16 ug/g by intravenous injection into mice
+Intravenous injection (23 ug/kg bodyweight) of the group C prothrombin activator causes death in rats through disseminated intravascular coagulopathy (PubMed:3075905), whereas pseutarin-C is not lethal even at 10 mg/kg in mice when injected intraperitoneally (PubMed:15351847)
+LD(50) is 100 ng/kg by subcutaneous injection in mice
+LD(50) is 180 ug/kg in mice
+PD(50) is 38 mg/kg into the insect A.domestica
+LD(50) is 10 ug/g on S.carnaria larvae
+The minimal hemorrhagic dose is 0.85 mg/kg by intradermal injection into mice
+LD(50) is 33-50 ug/g in S.carnaria larvae
+PD(50) is 25-33 ug/g in S.carnaria larvae
+LD(50) is 0.08 mg/kg by intravenous injection
+On fish, this toxin causes paralysis and death on intramuscular injection at doses of approximately 20 pmol/g. It does not kill mice even at extremely high doses
+LD(50) is 5.0 mg/kg by subcutaneous injection
+LD(50) is 28 +-7 mg/kg into third stadium larvae of M.sexta
+LD(50) is 5.5 mg/kg by intravenous injection
+Heterodimer (A and B chains): PD(50) is 2.5 nmol/g in sheep blowflies (Lucilia cuprina) (at 0.5 hours post-injection)
+Heterodimer (A and B chains): LD(50) is 3.0 nmol/g by injection into the ventro-lateral thorax of sheep blowflies (Lucilia cuprina)
+Heterodimer (A and B chains): LD(50) is 1.04 um/ml in Aedes albopictus mosquito C6/36 cells
+LD(50) is 1.98 mg/kg by intravenous injection
+LD(50) is 292.5 ug/kg by intravenous injection into mice
+LD(50) is 0.170 mg/kg by intravenous injection into mice for the minor toxin, and 0.125 mg/kg for the major toxin
+LD(50) is 0.076 mg/kg by subcutaneous injection
+LD(50) is 0.09 mg/kg by intramuscular injection into mice
+LD(50) is 1.24 mg/kg by intramuscular injection
+LD(50) is 1384 pmol/g when injected into house crickets (Acheta domestica)
+LD(50) is 0.22 mg/kg by subcutaneous injection
+LD(50) is 1.5 ug/mouse by intraperitoneal injection into mice
+PD(50) is 2.27 +-0.43 ug/g when injected into cricket (Acheta domestica) (observed at 60 minutes)
+LD(50) is 2.27 +-0.43 ug/g when injected into cricket (Acheta domestica) (observed at 24 hours)
+LD(50) is 0.41 mg/kg by intravenous injection into mice
+LD(50) is 100 ug/kg by intraperitoneal injection into mice
+LD(50) is 0.35 pg/kg by intracerebroventricular injection into mice
+PD(50) is 0.38 nmol/g in lepidopteran larvae
+LD(50) is 0.231 +- 32 nmol/g in blowfly adult (L.cuprina)
+LD(50) is 0.493 nmol/g in adult housefly (Musca domestica)
+LD(50) is 140 ug/kg by intravenous injection into mice
+LD(50) is 7.2 mg/kg by intravenous injection into mice
+PD(50) is 0.2-0.4 nmol/g when injected into the foot of the freshwater snail C.retropictus
+LD(50) is 2.1 +/- 0.2 mg/kg by intravenous injection
+LD(50) is 2.6 mg/kg by intraperitoneal injection in mice
+LD(50) is 0.13 mg/kg by intramuscular injection into mice
+LD(50) is 0.047 mg/kg by intravenous injection into mice
+LD(50) is 573 ng/g in P.americana
+LD(50) is 87 mg/kg by subcutaneous injection in mouse
+LD(50) is 1.2 mg/kg by intravenous injection into mice
+LD(50) is 11.7 mg/kg by intravenous injection
+LD(50) is 65 mg/kg by intraperitoneal injection into mice
+LD(50) is 0.06 mg/kg by subcutaneous injection
+LD(50) is 0.24 mg/kg by intravenous injection
+LD(50) is 3.6 mg/kg by intraperitoneal injection
+LD(50) is 0.87 mg/kg by intravenous injection into mice (tail vein)
+LD(50) is 0.021 mg/kg by intravenous injection into mice
+LD(50) is 1 ug/kg by injection at the junction between the body and the walking leg of crabs
+LD(100) is 5 ug/g when injected into fly larvae (M.domestica)
+LD(50) is 0.28 ug/g by intraperitoneal injection in A.carolinensis and 0.6 ug/g in H.frenatus
+LD(50) is 175 ug/kg by intraperitoneal injection into mice
+LD(50) is 10 pg/kg when injected into crabs
+LD(50) is 0.58 mg/kg by intravenous injection into mice
+LD(50) is 2.25 mg/kg in mice by subcutaneous injection
+LD(50) is 5.3 mg/kg by intraperitoneal injection into mice
+LD(50) is 1.5 mg/kg by intraperitoneal injection into mice
+LD(50) is 30 mg/kg by intravenous injection
+LD(50) is 17.6 nmol/kg to lepidopteran larvae
+LD(50) is 40 +-9 mg/kg into third stadium larvae of M.sexta
+LD(50) is 0.1 ug/ml against vascular endothelial cells in culture
+LD(50) is 170-280 ug/kg by intraperitoneal injection into mice
+LD(50) is 7.8 mg/kg by intraperitoneal injection into mice (PubMed:10860537). LD(50) is 7.75 mg/kg by intraperitoneal injection into mice (PubMed:9972319)
+LD(50) is 5.5 ug/kg by intracerebroventricular injection
+the LD(50) ranges from 0.040 mg/kg in adult blowflies to 24.1 mg/kg in mealworms
+LD(50) is 0.1 ug/g when injected intraperitoneally in mice
+LD(50) is 63 ug/kg by intraperitoneal injection into mice
+PD(50) is 1.15 pmol/100 mg (native toxin) or PD(50) is 2.65 pmol/100 mg (recombinant toxin) when injected inter-segmentally into blowfly larvae (S.falculata)
+LD(50) is >250 mg/kg by subcutaneous injection
+LD(50) is 1.25 ug/kg (25 ng/mouse) by intracerebroventricular injection into mice
+LD(50) is 4.9 +-0.05 umol/ml against L.infantum
+LD(50) is 25 mg/kg by intraperitoneal injection into mice
+LD(50) is 7.5 mg/kg by intravenous injection into mice
+LD(50) is 0.5 mg/kg by intracerebroventricular injection
+LD(50) is 133 pmol/g in the tobacco hornworm Manduca sexta (PubMed:1440641)
+LD(50) is more than 2.66 pmol/g against the beet armyworm Spodoptera exigua (PubMed:1440641)
+PD(50) is 700 +- 35 pmol/g in adult Australian sheep blowfly (Lucilia cuprina) (at 24 hours post-injection)
+LD(50) is 0.076 mg/kg by intravenous injection into mice
+LD(50) is 10 ug/kg by intramuscular injection into crabs
+LD(50) is 28.7 nmol/kg to cockroaches (Blattella germanica)
+LD(50) is 10.4 ug/kg by intracerebroventricular injection into mice and is 4.7 ug/g to cockroaches
+LD(50) is 5.6 mg/kg by intraperitoneal injection into mice
+LD(50) is 2.2 ug/kg to crabs
+LD(50) is 0.96 mg/kg by subcutaneous injection
+LD(50) is 7.5-8.5 mg/kg by intraperitoneal injection into mice
+LD(50) is 4.8 mg/kg by intravenous injection into mice
+LD(50) is 22 mg/kg when injected into crickets (Orthoptera) and LD(50) is 52 mg/kg when injected into common cutworms (Lepidoptera). PD(50) (irreversible paralysis) is 120 mg/kg when injected into cockroaches (observed 48 hours post-injection)
+LD(50) is 0.5 mg/kg in mouse (PubMed:10666623)
+LD(50) is 0.45 mg/ml against the termite species N.corniger
+LD(50) is 45.85 ug/ml against the brine shrimp A.nauplii
+LD(50) of the glycosylated form is 13.4 +/- 0.7 into crickets (G.assimilis)
+LD(50) of the non-glycosylated form is 5.8 +/- 0.3 nmol/g into crickets (G.assimilis)
+LD(50) is 15.4 mg/kg by intravenous injection
+LD(50) is 0.045 mg/kg by intravenous injection into mice
+PD(50) is 3-5 ng/100 mg of body weight of Sarcophaga larvae for both contraction and flaccid paralysis
+LD(50) is 2.5 mg/kg by intraperitoneal injection into mice
+LD(50) is 120 ug/kg to crabs
+LD(50) is 0.51 mg/kg by intravenous injection into mice
+LD(50) is 2.0 ug/mouse by intraperitoneal injection into mice
+Oligomer: LD(50) is 1 ug/kg by intraperitoneal injection into mice
+LD(50) is 27-37 ug/kg by intravenous injection into mice
+LD(50) is 0.025 mg/kg by intravenous injection
+LD(50) is 63.5 ug/kg by intravenous injection into mice (1.27 ug/mouse)
+PD(50) is 19 ng/100 mg of body weight of Sarcophaga larvae for contraction paralysis, and 85 ng/100 mg for flaccid paralysis
+LD(50) is 0.019 mg/kg by intraperitoneal injection (beta-1 bungarotoxin) and LD(50) is 0.028 mg/kg (beta-2 bungarotoxin)
+LD(50) is 3.61 mg/kg by intravenous injection into mice (tail vein)
+LD(50) is 1 mg/kg mice by intracerebroventricular injection into mice
+LD(50) is 236+-28 pmol/g in house crickets (Acheta domesticus) (at 48 hours post-injection)
+LD(50) is l43+-10 pmol/g in house crickets (Acheta domesticus) (at 72 hours post-injection)
+PD(50) is 147+-16 pmol/g in house crickets (Acheta domesticus) (at 48 hours post-injection)
+PD(50) is 124+-12 pmol/g in house crickets (Acheta domesticus) (at 72 hours post-injection)
+LD(50) is 160 ug/kg by intraperitoneal injection into mice
+Is lethal to mice by intraperitoneal injection of 0.5 ug (and higher doses)
+LD(50) is 0.4 ug/kg by intracerebroventricular injection into mice
+Heterodimer: LD(50) is 0.7-1.2 mg/kg by intraperitoneal injection into mice and 0.9-1.3 mg/kg by intravenous injection into mice
+Heterodimer: LD(50) is 0.9-1.3 mg/kg by intravenous injection into mice
+Monomer: LD(50) is 10-13 mg/kg by intraperitoneal injection into mice
+Monomer: LD(50) is 2.2-3.0 mg/kg by intravenous injection into mice
+LD(50) is 8.6 mg/kg by intravenous injection
+LD(50) is 0.3 mg/kg by subcutaneous injection
+LD(50) is 6.8 ug/kg by intracerebroventricular injection into mice
+LD(50) is 20 mg/kg in house crickets (Acheta domesticus)
+LD(50) is 40 ug/g in larvae of flesh fly S.carnaria
+LD(50) is 1.84 +-0.8 nmol/g in mealworm
+LD(50) is 170.5 +- 0.2 nmol/g when orally administered into mealworm
+LD(50) is 104.2 +-0.6 pmol/g when orally administred into the cotton bollworm H.armigera
+PD(50) is 420 ug/kg into crabs
+LD(50) is 0.8 mg/kg by intravenous injection into mice
+LD(50) is 400 mg/kg by intraperitoneal injection into mice
+LD(100) is 3500 ug/kg by intracerebroventricular injection into mice
+LD(50) of the recombinant toxin is 745 +- 108 pmol/g on D.melanogaster
+LD(50) of the native toxin is 914 +- 138 pmol/g on D.melanogaster
+LD(50) is 2.52 ug/ml against the brine shrimp A.salina
+Dose that inhibits collagen-triggered platelet aggregation of human plasma rich platelet (IC(50)) is 1.3 mmol/l
+LD(50) is 11.25 ug/kg by intracerebroventricular injection into mice but is not toxic (>1 mg/mouse) when injected subcutaneously
+Monomer: LD(50) is >30 mg/kg by intraperitoneal injection into mice
+PD(50) is 183 ug/kg into crabs
+LD(50) is 0.05 mg/kg by subcutaneous injection
+LD(50) is 50 ug/g in house crickets (Acheta domesticus)
+LD(50) is 0.12 mg/kg by intravenous injection into mice
+Dose that immobilizes and contracts insects (ED(50)) is 3.7 pmol/g body weight when intersegmentally injected into S.falculata
+LD(50) is 5 ug/kg by intracerebroventricular injection into mice (100 ng/mouse)
+LD(50) is 1.85 ug/kg by intracerebroventricular injection into mice
+PD(50) is 8.9 nmol/g by injection in blowfly
+PD(50) is 1335 +- 132 pmol/g in adult sheep blowflies (L.cuprina) (at 24 hours post-injection)
+LD(50) is 1688 +- 64 pmol/g in adult sheep blowflies (L.cuprina) (at 24 hours post-injection)
+LD(50) is 16 mg/kg by intravenous injection
+LD(50) is 250 ug/kg by intraperitoneal injection into mice
+LD(50) is 0.32 ug/kg by intraperitoneal injection into rats (at 48 hours post-injection)
+LD(50) is 1.73 ug/kg by intraperitoneal injection into mice (at 48 hours post-injection)
+LD(50) is 0.061 ug/kg by intraperitoneal injection into rats (at 14 days post-injection)
+LD(50) is 1.38 ug/kg by intraperitoneal injection into mice (at 14 days post-injection)
+LD(50) is 1.15 ug/kg (23 ng/mouse) by intracerebroventricular injection into mice
+LD(50) is 19.7 nmol/g to cockroaches (Blattella germanica)
+LD(50) is 50 ug/kg by intraperitoneal injection into mice
+LD(50) is 13.7 mg/kg by intravenous injection
+LD(50) is 20 ug/kg to freshwater crabs
+LD(50) is 3.0 mg/kg by intramuscular injection
+LD(50) is 5-25 ug/kg by intraperitoneal injection into crayfish
+LD(50) is 21 ug/kg by intracerebroventricular injection into mice
+LD(50) is 0.5 ug/mouse by intraperitoneal injection into mice
+LD(50) is 0.066 mg/kg by intraperitoneal injection in beta-3 bungarotoxin and 0.073 mg/kg in beta-4
+LD(50) is 0.73 pmol/g by intracranial injection into mice
+PD(50) is 5.8+-0.5 nmol/g when intra-thoracically injected into L.cuprina blowflies (at 30 minutes post-injection)
+PD(50) is 5.9+-0.4 nmol/g when intra-thoracically injected into L.cuprina blowflies (at 1 hour post-injection)
+PD(50) is 8.5+-0.9 nmol/g when intra-thoracically injected into L.cuprina blowflies (at 2 hours post-injection)
+LD(50) is 0.08 mg/kg by intramuscular injection into mice
+LD(50) is 4.82 mg/kg by intravenous injection
+LD(50) is 10-20 uM against zebrafish larvae
+LD(50) is 25 ng/kg by intracerebroventricular injection into mice, and LD(50) is 11 ug/kg by subcutaneous injection
+LD(50) is 163 ng/100 mg of body weight of cockroach (B.germanica) and 103 ng/100 mg of body weight of blowfly larvae (S.falculata)
+PD(50) is 110 ug/kg into zebrafish
+LD(50) is 20-40 ug/ml against killifish
+LD(50) is 6.25 mg/kg by intravenous injection
+LD(50) is between 5.3 and 5.5 mg/kg by intravenous injection into mice
+LD(50) is below 5 ug/kg by intracerebroventricular injection into mice. A rapid paralysis in the lower half of the body was observed a few minutes after the injection and after 10 min the animals died
+LD(50) is 0.036 mg/kg by subcutaneous injection
+LD(50) is 28 +-12 mg/kg into third stadium larvae of M.sexta
+LD(50) is 50 ug/kg to the shrimp P.paucidens (i.p.)
+LD(50) is 0.052 mg/kg by intraperitoneal injection
+LD(50) is 0.18 mg/kg by intraperitoneal injection
+LD(50) is 0.2 mg/kg by intraperitoneal injection in mice
+LD(50) is 65 ug/kg by intraperitoneal injection into mice (1.3 ug/mouse)
+LD(50) is 4.4 mg/kg by intravenous injection
+LD(50) is 0.2192 by intraperitoneal injection into mice
+LD(50) is 2.5 ug/kg when intracranially injected into mice
+LD(50) is 2.6 mg/kg by intravenous injection
+LD(50) is 53.1 mg/kg when injected into the thoracic region of insect larvae of H.armigera
+LD(50) is 0.09 mg/kg by subcutaneous injection
+LD(50) is 94 +/- 7 ug/kg by intravenous injection into mice
+LD(50) is 0.135 mg/kg on mice
+LD(50) is 0.35 mg/kg by intravenous injection
+PD(50) is 16.91 +-5.78 ug/kg into blowfly larvae (S.falculata)
+LD(50) is 4 mg/kg in house crickets (Acheta domesticus)
+LD(50) is 10.6 pmol on Drosophila
+LD(50) is 3.12 pmol/mg on Drosophila
+LD(50) is 45.54 pmol/mg when intrathoracically injected into drosophila
+LD(50) is 0.432 pmol/mg when intrathoracically co-injected with CSTX-1 (AC P81694) into drosophila
+LD(50) is 0.082 pmol/mg when intrathoracically co-injected with CSTX-13 (AC P83919) into drosophila
+Both variants Bjxtr-IT.56E and Bjxtr-IT.56K have an PD(50) of 9.6 ng/100 mg of body weight of blowfly larvae
+LD(50) is 70 ug/kg into crabs
+LD(50) is 0.04 mg/kg by subcutaneous injection
+LD(50) is 0.32 mg/kg by intravenous injection for RV-4 and 0.15 mg/kg for RV-4/RV-7 complex
+LD(50) is 4.5 ug/kg by intracerebroventricular injection into mice. Symptoms observed are trembling of tail, fasciculations, salivation, paralysis and death
+LD(50) is 0.013-0.027 mg/kg by intracerebroventricular injection into mice
+LD(50) is 0.076 mg/kg by intramuscular injection into mice
+LD(50) is 1.40 mg/kg by subcutaneous injection
+LD(50) is 2.6 mg/kg by subcutaneous injection
+LD(50) is 82 mg/kg by intravenous injection
+LD(50) is 0.95 mg/kg by intraperitoneal injection in mice
+LD(50) is 0.12 mg/kg by subcutaneous injection
+PD(50) is 3 umol/kg in tobacco budworms (Heliothis armigera)
+PD(50) is 0.25 umol/kg in tobacco budworms (Heliothis virescens)
+LD(50) is 89-91 pmol/g (0.38 mg/kg) to house crickets (Acheta domesticus)
+LD(50) is 86.5 pmol/g in house flies (Musca domestica)
+LD(50) is 716 +-23 pmol/g (3.00 +-0.10 ug/g) when orally administered into lone star ticks (Amblyomma americanum)
+LD(50) is 447 +-3 pmol/g (1877 +-0.013 ug/g) when injected into lone star ticks (Amblyomma americanum)
+LD(50) is 147 nmol/g in triatomine bug (Rhodinius prolixus)
+PD(50) is 0.32 umol/kg in Periplaneta americana
+LD(50) is 0.07 mg/kg by intraperitoneal injection for pelamitoxin A
+Monomer: LD(50) of DbTx-B alone is estimated to be 0.5 ug/g by intraperitoneal injection into mice
+Heterodimer (A and B chains): LD(50) is estimated to be about 0.1 ug/g by intraperitoneal injection into mice
+LD(100) is 0.75 mg/kg by intravenous injection and 2.25 mg/kg by intraperitoneal injection
+LD(50) is 16.3 pmol/mg in Drosophila
+LD(50) is 111.2 pmol/mg when intrathoracically injected into drosophila
+LD(50) is 0.075 pmol/mg when intrathoracically co-injected with CSTX-1 (AC P81694) into drosophila
+LD(50) is 0.082 pmol/mg when intrathoracically co-injected with CSTX-9 (AC P58604) into drosophila
+LD(50) is 0.56 mg/kg by intraperitoneal injection into mice
+LD(50) is 0.14 mg/kg by intravenous injection into mice
+LD(100) is 0.58 mg/kg to crayfish
+LD(50) is 4.7 ug by subcutaneous injection into mice (235 ug/kg)
+LD(50) is 826 +/- 156 ug/kg by intravenous injection into mice
+LD(50) is 11 +/- 9 ug/kg by intracistenal injection into mice
+LD(50) is 0.6 ng by intracerebroventricular injection into mice (30 ng/kg)
+LD(50) is 1.7 ng by intracerebroventricular injection into mice (85 ng/kg)
+The LD(50) ranges from 0.25 mg/kg in adult blowflies to 23.7 mg/kg in cockroaches;
+LD(50) is 60 ug/kg to insect (Galleria mellonella) larvae
+In monomer CBb, LD(50) is 500 ug/kg by intravenous injection into mice
+In class 1 heterodimer CA2-CBb, LD(50) is 110 ug/kg by intravenous injection into mice
+In class 1 heterodimer CA3-CBb, LD(50) is 95 ug/kg by intravenous injection into mice
+PD(50) is 2.37 +/- 0.12 mg/kg by injection into the abdomen of larvae of H.virescens
+LD(50) is 66 ug/g in larvae of flesh fly S.carnaria
+LD(50) is 35 ug/kg by intravenous injection into mice
+LD(50) is 198 +- 33 pmol/g when injected into the ventro-lateral thoracic region of adult blowflies (L.cuprina) (at 24 hours post-injection) (PubMed:26073605)
+PD(50) is 0.89 nmol/g when injected into tobacco budworm (PubMed:9589602)
+PD(50) is 0.78 nmol/g when injected into cabbage looper (PubMed:9589602)
+PD(50) is 0.9 nmol/g when injected into beet army worm (PubMed:9589602)
+PD(50) is 2.0 nmol/g when injected into Southern corn rootworm (PubMed:9589602)
+LD(50) is 5.1 +- 0.5 nmol/g on lepidopteran larvae (Spodoptera litura)
+LD(50) is 0.35 mg/kg by subcutaneous injection
+LD(50) is 2 ug/kg against crabs
+LD(50) is 0.13 mg/kg by intravenous injection
+LD(50) is 0.1 mg/kg in Blattella germanica
+LD(50) is 15 ug/kg by intracerebroventricular injection into mice
+LD(50) is 9.3 ng/house fly
+PD(50) is 0.099 ng/mg of insects
+the LD(50) ranges from 0.017 mg/kg in adult blowflies to 13.0 mg/kg in cockroaches
+LD(50) is 65 ug/g in flesh fly larvae (S.carnaria)
+LD(50) is 60 ug/g in house crickets (Acheta domesticus)
+LD(50) is 4.14 mg/kg by intravenous injection
+LD(50) is 120 ug/kg by intraperitoneal injection into mice
+LD(50) is 0.51-0.583 mg/kg by intraperitoneal injection into mice
+LD(50) of waglerin-2 is 0.51 mg/kg by intraperitoneal injection into mice
+LD(50) is 3.8 mg/kg by intravenous injection into mice
+LD(50) is 0.07 mg/kg by intracerebroventricular injection into mice
+LD(50) is 19 ug/g on fly larvae (M.domestica) (4.4 nmol/g of body weight)
+LD(50) is 20 ug/g on juvenile cockroaches (G.portentosa)
+LD(100) is 100 ug/g when tested on larvae of the housefly Musca domestica
+LD(50) is 0.02 ug/g by subcutaneous injection into moth (Manduca sexta)
+LD(50) is 830 ug/kg into crabs
+LD(50) is 1.82 mg/kg by intravenous injection
+LD(50) is 80 ug/kg against crab (P.dehaani)
+LD(50) is 0.10 mg/kg by intravenous injection
+LD(50) is >300 ug/kg by intraperitoneal injection into mice
+LD(50) is 2.5 mg/kg by intravenous injection into mice
+PD(50) is 12 mg/kg when injected into tobacco budworm larvae (H.virescens)
+LD(50) of the heterodimer is 260.1 +- 16.6 pmol/g towards D.melanogaster
+LD(50) is 1.9 mg/kg by intracerebroventricular injection into mice
+LD(50) is 0.067 mg/kg by subcutaneous injection
+LD(50) is 20.9 mg/kg by intrathoracic injections into adult house flies (Musca domestica)
+LD(50) is 20 ug/kg by intravenous injection into mice and 5 ug/kg by intraperitoneal injection into crayfish
+LD(50) is 0.772 mg/kg by intraabdominal injection into mice
+120 mg/kg body weight concentration is able to paralyze 67% of the crickets (PD(67) is 120 mg/kg)
+PD(50) is 130 ng/g body weight to blowfly larvae, PD(50) is 50 ng/g body weight to locusts (Locusta migratoria). Not toxic by subcutaneous injection into mice
+LD(50) is 450 ug/kg by intraperitoneal injection into mice
+Monomer: LD(50) is 4 mg/kg by intravenous injection into mice
+LD(50) is 0.086 mg/kg by intravenous injection
+LD(50) is >20 mg/kg by intravenous injection
+LD(50) is 7 mg/kg on H.virescens larvae
+LD(50) is 40.0 ng/house fly
+PD(50) is 0.71 nmol/g in lepidopteran larvae
+LD(50) is 1.5 mg/kg by intravenous injection
+LD(50) is 32.8 mg/kg by intraperitoneal injection into mice
+LD(50) is 320 ug/kg by intravenous injection into mice
+LD(50) is 70 ug/kg to crabs
+Dose that causes degranulation of mast cells (ED(50)) is 10 uM
+LD(50) is 0.95 mg/kg by intraperitoneal injection
+LD(50) is 75 +-27 mg/kg into third stadium larvae of M.sexta
+LD(50) is 400 +/- 83 ug/kg by intraperitoneal injection into mice
+LD(50) is 38 mg/kg by intravenous injection
+LD(50) is 25 ug/kg by subcutaneous injection into mice and 0.25 ug/kg by intracerebroventricular injection
+LD(100) is 3 ug/kg by intracranial injection into mice
+LD(50) is 24 ug/kg to freshwater crabs
+LD(50) is 5.9 pmol/mg on Drosophila
+LD(50) is 0.06 mg/kg by intraperitoneal injection into mice
+LD(50) is 224 pmol/g when injected into house crickets (Acheta domestica)
+LD(50) is 2.85 mg/kg by intravenous injection
+LD(50) is 8 mg/kg by intraperitoneal injection into mice
+LD(50) is 61 nmol/g by intraabdominal injection into cricket A.domestica
+LD(50) is 0.36 mg/kg by intravenous injection into mice
+LD(50) is 50 mg/kg by intracerebroventricular injection into mice
+LD(50) of stonustoxin is 0.017 mg/kg by intravenous injection
+PD(50) is 0.18 ng/mg of Gryllus bimaculatus crickets
+PD(50) is 4.01 nmol/g when injected into D.melanogaster
+LD(50) is 36 ng/kg by intravenous injection into mice
+LD(50) is 0.535 pmol/mg when intrathoracically injected into drosophila
+LD(50) is 0.432 pmol/mg when intrathoracically co-injected with CSTX-9 (AC P58604) into drosophila
+LD(50) is 0.075 pmol/mg when intrathoracically co-injected with CSTX-13 (AC P83919) into drosophila
+LD(50) is 2.58 pmol/mg on Drosophila
+LD(50) is 66.51 pmol/mg on Drosophila
+LD(50) is >2 mg/kg by intraperitoneal injection into mice
+LD(50) is 5.8 ug/kg against crabs
+LD(50) is 4.7 mg/kg by intravenous injection
+LD(50) is 0.096 mg/kg by intramuscular injection into mice
+LD(50) is 0.085 mg/kg by intravenous injection
+LD(50) is 6.6 mg/kg by intravenous injection
+LD(50) is 4 mg/kg +/- 0.25 by intravenous injection into mice
+LD(50) is 0.15 mg/kg by subcutaneous injection
+LD(50) is 8.2 mg/kg by intraperitoneal injection into mice
+LD(50) is 3.1 ug/mouse and LD(100) is 3.7 ug/mouse by intraperitoneal injection into mice
+LD(50) is 4.2 mg/kg when intraperitoneally injected into mice
+LD(50) is 12 ug/kg when intracutaneously injected into mice
+LD(50) is 15 ug/kg when on crabs
+LD(50) of 13.5 mg/kg in mouse
+LD(50) is 180 ug/kg by subcutaneous injection into mice
+PD(50) is 4.73 nmol/g when injected into D.melanogaster
+LD(50) is 25 ug/kg by intracerebroventricular injection into mice
+LD(50) is 5.21 ug/ml against the brine shrimp A.salina
+LD(50) is 23.1 ug/ml against the aquatic snail B.glabrata
+LD(50) is 140 ug/kg by intraventricular injection into mice
+LD(50) is 3.1 nmol/kg in lepidopteran larvae
+LD(50) is 0.74 pmol/g by intracranial injection into mice
+LD(50) is 15 mg/kg by intravenous injection into mice
+LD(100) is 4 ug/kg by intracranial injection into mice
+LD(50) is 83 ug/kg by intravenous injection into mice
+LD(50) is 6.4 pmol/mg on Drosophila
+LD(50) is 12 mg/kg by intraperitoneal injection
+LD(50) is 16.1 mg/kg by subcutaneous injection
+LD(50) is 0.28 ug/kg to crabs
+LD(50) is 1.37 mg/kg by intravenous injection
+When injected intraperitoneally or subcutaneously in mice, this toxin causes motor impairment/paralysis and is lethal at doses as low as 0.6 nmol per mouse
+LD(50) is 75 ug/kg by intracerebroventricular injection into mice
+LD(50) is 150 ug/kg by subcutaneous injection into mice
+LD(50) is 2.61 mg/kg by intraperitoneal injection into mice
+LD(50) is 160 ng/100 mg of body weight of cockroach (B.germanica) and 81 ng/100 mg of body weight of blowfly larvae (S.falculata)
+LD(50) is 0.01 mg/kg by intracerebroventricular injection in mice
+LD(50) is 25 mg/kg by intravenous injection
+LD(50) is 0.11 mg/kg by intravenous injection
+LD(50) is 1.3 mg/kg intraperitoneal injection into mice
+LD(50) is 53.5 mg/kg by intravenous injection into mice
+LD(50) is 1.6 mg/kg by subcutaneous injection into mice
+LD(50) is 2.1 mg/kg by intravenous injection into mice
+LD(50) is 56 mg/kg by subcutaneous injection into mice
+LD(100) is 30 ug/g on the shrimp C.multidentata
+LD(50) is 30 ug/g when injected into fly larvae (M.domestica)
+LD(50) is 3.8 ng/house fly
+PD(50) of HwTx-III is 192.95 +/- 120.84 mg/kg to locusts
+LD(50) is 4 nmol/g in flies (M.domestica)
+LD(50) is 230 pmol/g in cockroaches (P.americana)
+LD(50) is 25.2 mg/kg by intravenous injection
+LD(50) is 0.2 ug/mL on cultured vascular endothelial cells
+LD(50) is 23 mg/kg by intravenous injection
+LD(50) is 0.31 (0.22-0.41) mg/kg by intramuscular injection into goldfish (after 4 hours)
+LD(50) is 10 mg/kg by intravenous injection into mice
+Dose that lyses erythrocyte suspension (ED(50)) is 0.86 ug/ml
+LD(50) is 50 ug/kg by subcutaneous injection in mouse, 60 ng/g in Blattella germanica and 120 ng/g in Musca domestica
+LD(50) is between 0.05 and 0.20 mg/kg by intraperitoneal injection into mice. These data should be viewed cautiously since only a few mice have been injected due to the low amount of toxin available
+PD(50) is 5.6+-0.2 nmol/g when intra-thoracically injected into L.cuprina blowflies (at 30 minutes post-injection)
+PD(50) is 6.0+-0.2 nmol/g when intra-thoracically injected into L.cuprina blowflies (at 1 hour post-injection)
+PD(50) is 7.7+-0.5 nmol/g when intra-thoracically injected into L.cuprina blowflies (at 2 hours post-injection)
+LD(50) is 9.2 +-0.9 mg/kg in juvenile house crickets (Acheta domesticus)
+LD(50) is 0.4 ug/100 mg of insect (after 48 hours) and 0.2 ug/100 mg of insect (after 72 hours) by injection into Locusta migratoria larvae
+PD(50) is 255 mg/kg of insects (crickets)
+60 mg/kg body weight of a mixture of this protein and Ves a 1.02 is able to paralyze 33% of the crickets
+LD(50) is 3.4 mg/kg by intravenous injection
+LD(50) is 520 ug/kg against crab (P.dehaani)
+LD(50) of waglerin-1 is 0.33-0.369 mg/kg by intraperitoneal injection into mice
+LD(50) of waglerin-3 is 0.22 mg/kg by intraperitoneal injection into mice
+LD(50) is 0.083 mg/kg by intraperitoneal injection
+LD(50) is 0.9 ug/kg by intracerebroventricular injection into mice
+LD(50) is 0.75 ug/kg by intracerebroventricular injection into mice
+LD(50) is 1.11 mg/kg by intravenous injection
+LD(50) is 0.105 mg/kg by subcutaneous injection
+LD(50) is 0.11 mg/kg by subcutaneous injection
+LD(50) is 20 ug/kg in mice
+LD(50) is 0.045 mg/kg by subcutaneous injection for variant I, and 0.08 mg/kg for variant V
+LD(50) is 600 ug/kg by intraperitoneal injection into mice
+LD(50) is 38 +-12 mg/kg into third stadium larvae of M.sexta
+LD(50) is 15 ug/kg to insect (Galleria mellonella) larvae
+LD(50) is 10.8 +- 1.4 mg/kg in juvenile house crickets (Acheta domesticus)
+LD(50) is 0.09 mg/kg by intravenous injection
+LD(50) is 0.15 mg/kg by intravenous injection into mice
+LD(50) is 142 ng/100 mg of body weight of cockroach (B.germanica) and 78 ng/100 mg of body weight of blowfly larvae (S.falculata)
+LD(50) is >100 uM against zebrafish larvae
+LD(50) is 0.25-0.5 mg/kg by intravenous injection into mice
+LD(50) is 0.12 ug/kg in mouse by intracerebroventricular injection and LD(50) is 115 ug/kg in mouse by subcutaneous injection
+LD(50) is 15 mg/kg by intravenous injection
+LD(50) is 118.5 by intraperitoneal injection into mice
+LD(50) is 50 ug/kg in mouse by intracerebroventricular injection and 600 ng/g in Blattella germanica
+LD(50) is 0.10 mg/kg by intramuscular injection into goldfish
+LD(50) is 0.21 (0.18-0.24) mg/kg by intramuscular injection into goldfish (after 4 hours)
+PD(50) is 13 ug/g in insect larvae (S.frugiperda) (at 8 hours post-injection)
+PD(50) is 2.9 +-0.9 nmol/g in blowfly (L.caesar) (at 1 hour post-injection)
+LD(50) is 0.015 mg/kg by intraperitoneal injection into mice
+PD(50) is 21.5 mg/kg of insects (crickets)
+PD(50) is 0.05 ug/g (6.6 pmol/g) in house crickets (Acheta domesticus)
+LD(50) is <0.1 ug/g (<13.3 pmol/g) in house crickets (Acheta domesticus)
+LD(50) of recombinant toxin is 320 +-20 pmol/g in house flies (Musca domestica)
+LD(50) of recombinant toxin is 91 +-5 pmol/g in house flies (Musca domestica)
+LD(50) is 10 mg/kg on H.virescens larvae
+PD(50) are 2.2 +-0.2 and 1.5 +-0.3 nmol/g (native and recombinant toxins, respectively) when injected into sheep blowfiles (L.cuprina)
+LD(50) is 1.5 mg/kg by subcutaneous injection into mice
+In class 1 heterodimer CA2-CBc, LD(50) is 80 ug/kg by intravenous injection into mice
+In class 1 heterodimer CA3-CBc, LD(50) is 110 ug/kg by intravenous injection into mice
+In class 1 heterodimer CA2-CBd, LD(50) is 70 ug/kg by intravenous injection into mice
+In class 1 heterodimer CA2-CBd, LD(50) is 150 ug/kg by subcutaneous injection into mice
+In class 1 heterodimer CA3-CBd, LD(50) is 90 ug/kg by intravenous injection into mice
+LD(50) is 0.0956 mg/kg by intraperitoneal injection into mice
+LD(50) is 7 mg/kg in flesh fly larvae (S.carnaria)
+LD(50) is 93 ug/kg into crabs
+LD(50) is 0.10 to 0.15 mg/kg by subcutaneous injection
+LD(50) is 2.5 mg/kg of body weight by intravenous injection into mice
+LD(50) is 0.25 mg/kg by intraperitoneal injection into mice
+LD(50) is 40 +/- 3 mg/kg by intravenous injection into mice
+LD(50) is 9.7 mg/kg by intravenous injection into mice
+LD(50) is 230 ug/kg by intraperitoneal injection into mice
+LD(50) is 50 ug/g in flesh fly larvae (S.carnaria)
+PD(50) is 0.96 nmol/g in Lucilia cuprina (at 0.5-1 hour post-injection). No paralytic or lethal effects are observed 24 hours post-injection
+Injection of recombinant toxin into Drosophila melanogaster induces irreversible paralysis leading to death. PD(50) is 0.285 nmol/g (at 3 hours post-injection). PD(50) is 1.9 nmol/g (at 24 hours post-injection). LD(50) is 4.3 nmol/g (at 24 hours post-injection)
+LD(50) is 565 ug/kg by intraperitoneal injection into mice
+LD(50) is 0.21 mg/kg by intravenous injection
+LD(50) is 54 mg/kg by intravenous injection
+LD(50) is 2.7 ug/ml against killifish
+LD(50) is 4 mg/kg on H.virescens larvae
+LD(50) is 1.4 mg/kg when intraperitoneally injected into mice
+the LD(50) ranges from 0.076 mg/kg in adult blowflies to 29.0 mg/kg in mealworms
+LD(50) is 0.045 mg/kg by intravenous injection
+LD(50) is 9.4 mg/kg by intravenous injection
+PD(50) is 80 ul to crickets (Gryllus sp)
+LD(50) is 75 ug/g on flesh fly larvae (S.carnaria)
+PD(50) is 75 ug/g on M.sexta first instar larvae
+LD(50) is 18.2 mg/kg by intraperitoneal injection into mice
+In monomer CBc, LD(50) is 480 ug/kg by intravenous injection into mice
+LD(50) is 1.89 mg/kg by intraperitoneal injection into mice (at 48 hours post-injection)
+LD(50) is 0.95 mg/kg by intraperitoneal injection into mice (at 14 days post-injection)
+LD(50) is 48 +-11 mg/kg into third stadium larvae of M.sexta
+LD(50) is 53 ug/kg when intraperitoneally injected into mice
+LD(50) is 2.4 ug/kg when intracutaneously injected into mice
+LD(50) is 10 ug/kg when on crabs
+LD(50) is 5.6 mg/kg (95 ug/16-18 g) by intravenous injection into mice (PubMed:2873948). LD(50) is 25 ug/kg (0.42 ug/16-18 g) by intracerebroventricular injection into mice (PubMed:2873948). LD(50) is 8 mg/kg by intravenous injection into mice (PubMed:2327788)
+LD(50) is 0.05 mg/kg by intravenous injection
+LD(50) is 40 to 55 mg/kg by subcutaneous injection
+LD(50) is 20.3 +/- 3.0 mg/kg to the insect S.litura
+LD(50) is 0.7 mg/kg by intraperitoneal injection into mice
+LD(50) is 9.40 ug/kg by intracisternal injection into mice
+LD(50) is 0.07 mg/kg by intravenous injection into mice
+LD(50) is 1.2 mg/kg by intravenous injection
+LD(50) is 4.3 mg/kg by intraperitoneal injection into mice
+LD(50) 0.15 pmol/g by intracranial injection into mice
+LD(50) is 1.2 nmol/kg in lepidopteran larvae
+PD(50) is 0.103 mg/kg by injection in blowfly larvae
+LD(50) is 1 mg/kg by intraperitoneal injection into mice. This injection causes irregular respiration, paralysis, convulsions and death
+LD(50) is 3-5 mg/ kg by intravenous injection into mice
+LD(50) is 0.20 mg/kg by subcutaneous injection
+LD(50) is more than 100 pmol/g body weight (at 24 hours) when injected into the haemocoel of the wax moth G. mellonella larvae
+LD(50) is > 0.245 mg/kg by intraperitoneal injection into mice
+PD(50) is 1318 +-58 pmol/g when injected into the ventro-lateral thoracic region of adult sheep blowflies (L.cuprina). Remarkably, all flies fully recovers from the initial paralytic effects induced by this toxin at doses up to 8.17 nmol/g
+Monomer: LD(50) is 500 ug/kg when injected into mice
+Heterotrimer: LD(50) is 50-100 ug/kg when injected into mice
+LD(50) is 5.09 mg/kg by subcutaneous injection
+LD(50) is 2.61 mg/kg by subcutaneous injection
+LD(50) is 3 mg/kg by intravenous injection
+LD(50) is 0.3 mg/kg by injection into mice
+LD(50) is 0.06 mg/kg by intracerebroventricular injection into mice
+LD(50) is 33.56 ug/ml against A.nauplii
+LD(50) is 48 mg/kg by subcutaneous injection into mice
+LD(50) is 256 +/- 23 ug/kg by injection into the fourth ventricle of the adult mouse brain
+LD(50) is 80 mg/kg by intraperitoneal injection into mice
+LD(50) is 0.13 mg/kg by intraperitoneal injection
+Dose that causes mild to moderate seizure (ED(50)) is 5 nmol when intracranially injected into mice. With 20 nmol injected per mouse, most of the mice developed severe seizures and died
+LD(50) is 4.7 pmol/mg on Drosophila
+LD(50) is less than 25 ug/kg in mouse by intracranial injection
+LD(50) is 0.53 ug/kg to crabs
+Is not lethal to mice even at 10 mg/kg
+PD(50) is 5.0 +- 0.3 nmol/g on lepidopteran larvae (Spodoptera litura)
+PD(50) is 0.36 mg/kg by injection in blowfly larvae, in PubMed:12885226
+PD(50) is 0.557 mg/kg by injection in blowfly larvae, in PubMed:15824108
+LD(50) is 0.23 mg/kg by intravenous injection
+LD(50) is 33.5 mg/kg by intravenous injection into mice
+LD(50) is 4.9 mg/kg by intravenous injection
+LD(50) is 2.0 ug/kg by intracerebroventricular injection into mice
+LD(50) is 2.98 mg/kg by intravenous injection
+LD(50) is 2.9 mg/kg by intravenous injection in mice. Toxicity is higher in combination with subunit A
+LD(50) is 28.5 ug/kg by intracranial injection into mice
+LD(50) is 27 +- 11 ug/g in crickets
+LD(50) is in the range of 6.25-12.5 mg/kg by intraperitoneal injection into mice
+LD(50) is 0.4 mg/kg by intracerebroventricular injection into mice
+LD(50) is >3.3 mg/kg by intraperitoneal injection
+LD(50) is 0.05 mg/kg by intracerebroventricular injection into mice
+LD(50) is 125 ng/kg (2.5 ng/mouse) by intracerebroventricular injection into mice, 3.4 pmol/g by subcutaneous injection in mouse and 2317 pmol/g in Blattella germanica
+LD(50) is 0.16 ug/g by intravenous injection into mice
+LD(50) of native toxin is 29.5 ug/kg by intravenous injection into mice. LD(100) is 39 ug/kg by intravenous injection into mice
+LD(50) of recombinant toxin is 167 ug/kg by intravenous injection into mice
+LD(50) is 24.2 ng/mg body weight of lepidoptera larvae
+PD(50) is 25.8 nmol/g 1 hour after injection into L.cuprina. LD(50) is >100 nmol/g 24 hours after injection into L.cuprina
+LD(50) is 62.5 mg/kg by subcutaneous injection
+LD(50) is 1.48 mg/kg by intraperitoneal injection
+LD(50) is 0.015 mg/kg by intravenous injection into mice
+LD(50) is 0.3 mg/kg by intravenous injection into mice
+LD(50) is 0.2 mg/kg by intravenous injection
+LD(50) is 80 ug/kg by intraperitoneal injection into crayfish
+LD(50) is 0.85 mg/kg when injected intravenously in mice
+LD(50) is >250 mg/kg by intravenous injection
+PD(50) is 2.60 nmol/g when injected into tobacco budworm
+PD(50) is 0.23 nmol/g when injected into cabbage looper
+PD(50) is 0.3 nmol/g when injected into beet army worm
+PD(50) is 0.57 nmol/g when injected into southern corn rootworm
+Dose that causes constriction of the isolated rat ileum muscles (ED(50)) is 3.8 uM. Dose that causes degranulation of mast cells (ED(50)) is 100 uM
+LD(50) is 100 ug/kg to the crayfish Procambarus cubensis
+LD(50) is 1 ug/kg by intracerebro-ventricular injection in mice
+LD(50) is 4.0 mg/kg by intravenous injection
+LD(50) is 2.8 nmol/g of body weight, when intraperitoneally injected into cockroaches
+LD(50) is 25 uM against zebrafish larvae
+LD(50) is 8.5 ug/g in Blattella germanica
+LD(50) is 35 ug/g in flesh fly larvae (S.carnaria)
+LD(50) is 30 ug/g in house crickets (Acheta domesticus)
+LD(50) is 1.9 ug/ml against killifish
+LD(100) is 2 ug/kg by intracerebroventricular injection into mice
+LD(50) is 722 ug/kg by intravenous injection into mice
+LD(50) is >16 mg/kg by intramuscular injection into goldfish (C.carassius)
+LD(50) is 106 mu/kg in crayfish
+LD(50) is 2 ug/kg by intracerebroventricular injection into mice
+Dose that produces hyperactivity (ED(50)) is 1.8 pmol/g body mass (native toxin), 1.9 pmol/g body mass (synthetic toxin) and 3.9 pmol/g body mass (P13A mutant)
+LD(50) is 0.1 mg/kg by intraperitoneal injection
+LD(50) of the heterotrimer is 50-100 ug/kg to mice
+LD(50) is 5.1 +/- 1.3 mg/kg by intraperitoneal injection into mice
+LD(50) is 2.3 +/- 0.8 mg/kg by intravenous injection into mice
+LD(50) is 210 ug/kg by intraperitoneal injection into mice
+Monomer: DbTx-A alone is non-lethal, even at doses as high as 2 ug/g
+PD(50) is 707 ug/kg in U.thayeri crabs