{"text": ". First, a HITI donor template bearing a CMV promoter-driven copGFP reporter gene flanked by 20-nt ITGB2-specific sgRNA target sequences (designated ITGB2-ts) was constructed and packaged within recombinant adeno-associated virus serotype 6 (rAAV6) caps", "synonym_substitution": ". First, a HITI donor template bearing a CMV promoter - driven copGFP reporter gene flank by 20 - national trust ITGB2 - specific sgRNA aim sequences (indicate ITGB2 - ts) was manufacture and packaged within recombinant adeno - associated virus serotype 6 (rAAV6) cap", "butter_fingers": ". Figst, a HITI donor templatt bearing a CMV ptonoter-dciven ckpGFP reoorter gene flanked by 20-nt ITJB2-spwcifix sgRNA target sequencds (designwted ITGV2-ts) xas constructed ehd packaged wjbhin xerombinant adeno-sssociated virus serotypa 6 (rCAV6) caps", "random_deletion": ". First, a HITI donor template bearing promoter-driven reporter gene by 20-nt ITGB2-specific was and packaged within adeno-associated virus serotype (rAAV6) caps", "change_char_case": ". First, a HITI donor template beAring a CMV pRomotEr-dRivEn CopGfP rePorter gene flanKEd by 20-Nt ITGB2-specific sgRNA tarGet seQuENces (DEsIgnatEd ITGB2-tS) WaS COnsTrUcTed AnD PaCkageD wiThin recOmbinant adEno-AsSociated viruS SeRotype 6 (rAAV6) CapS", "whitespace_perturbation": ". First, a HITI donor temp late beari ng aCMV  pr om oter -dri ven copGFP rep o rter  gene flanked by 20-nt  ITGB 2- s peci f ic  sgRN A targe t  s e q uen ce s(de si g na ted I TGB 2-ts) w as constru cte dand packaged wi thin recom bin ant adeno-as soc iatedvi rus serot ype  6 (r AAV6)c aps", "underscore_trick": ". First,_a HITI_donor template bearing a_CMV promoter-driven_copGFP_reporter gene_flanked_by 20-nt ITGB2-specific_sgRNA target sequences_(designated ITGB2-ts) was constructed_and packaged within_recombinant_adeno-associated virus serotype 6 (rAAV6) caps"}
{"text": "rites, and N-nitroso compounds, and higher serum levels of polychlorinated biphenyls have been associated with increased risk. With respect to type 2 diabetes, data on arsenic and TCDD in relation to risk were suggestive of a direct association. The occupational data suggested that more data on exposure to", "synonym_substitution": "rites, and N - nitroso compounds, and higher serum levels of polychlorinated biphenyls have been consociate with increase risk. With respect to type 2 diabetes, data on arsenic and TCDD in relative to risk were suggestive of a lineal association. The occupational data suggested that more datum on vulnerability to", "butter_fingers": "ritfs, and N-nitroso compoundr, and higher setun levens of lolychlofinated biphenyls have been essoxiatee with increased risk. Dith respvct to type 2 viabetes, data on arsenic and TDFD iu celation to risl were sugcestive of a dhrdcc association. The occupational data fuggestrd that more datw on qxpoalrt to", "random_deletion": "rites, and N-nitroso compounds, and higher serum polychlorinated have been with increased risk. diabetes, on arsenic and in relation to were suggestive of a direct association. occupational data suggested that more data on exposure to", "change_char_case": "rites, and N-nitroso compounds, And higher sErum lEveLs oF pOlycHlorInated biphenylS Have Been associated with incrEased RiSK. WitH ReSpect To type 2 dIAbETEs, dAtA oN arSeNIc And TCdD iN relatiOn to risk weRe sUgGestive of a diREcT associatiOn. THe occupationAl dAta sugGeSteD That mOre Data oN exposURe to", "whitespace_perturbation": "rites, and N-nitroso compo unds, andhighe r s eru mleve ls o f polychlorina t ed b iphenyls have been ass ociat ed with in creas ed risk .  W i t h r es pe ctto ty pe 2dia betes,data on ar sen ic  and TCDD in re lation toris k were sugge sti ve ofadir e ct as soc iatio n. The occupa tional da ta sugges t ed that m or e da ta on exposure to ", "underscore_trick": "rites, and_N-nitroso compounds,_and higher serum levels_of polychlorinated_biphenyls_have been_associated_with increased risk._With respect to_type 2 diabetes, data_on arsenic and_TCDD_in relation to risk were suggestive of a direct association. The occupational data suggested_that_more data_on_exposure_to"}
{"text": "PP, and we are using next-generation sequencing to identify causative variants in known and novel candidate genes. Examining the genetic characteristics of subjects with pubertal disorders will reveal insights into the mechanisms underlying the reawakening of the hypothalamic-pituitary-gonadal axis at puberty. This will provide", "synonym_substitution": "PP, and we are using next - generation sequencing to name causative random variable in known and novel campaigner genes. examine the genetic characteristic of topic with pubertal disorders will uncover insights into the mechanisms underlie the reawakening of the hypothalamic - pituitary - gonadal axis at puberty. This will provide", "butter_fingers": "PP, wnd we are using next-gentration sequenciny to idxntify dausativd variants in known and novep xandieate genes. Examining tfe genetib charactwrisuics of subjects xjth pubcxtal slsordzrw will reveal lnsights indo the mechanivmr bnderlying the reawakening of the hy[othalakif-pituitary-gonaqal svis zn kuberty. This will provide", "random_deletion": "PP, and we are using next-generation sequencing causative in known novel candidate genes. subjects pubertal disorders will insights into the underlying the reawakening of the hypothalamic-pituitary-gonadal at puberty. This will provide", "change_char_case": "PP, and we are using next-generaTion sequenCing tO idEntIfY cauSatiVe variants in knOWn anD novel candidate genes. ExAminiNg THe geNEtIc chaRacteriSTiCS Of sUbJeCts WiTH pUbertAl dIsorderS will reveaL inSiGhts into the mEChAnisms undeRlyIng the reawakEniNg of thE hYpoTHalamIc-pItuitAry-gonADal axiS at pubertY. THIs will PRovide", "whitespace_perturbation": "PP, and we are using next- generation  sequ enc ing  t o id enti fy causative v a rian ts in known and novelcandi da t e ge n es . Exa miningt he g ene ti ccha ra c te risti csof subj ects withpub er tal disorder s  w ill reveal  in sights intothe  mecha ni sms under lyi ng th e reaw a kening  of the h yp o thalam i c-pitui t a ry -gon adal axis at pube r ty .  This will pro vide", "underscore_trick": "PP, and_we are_using next-generation sequencing to_identify causative_variants_in known_and_novel candidate genes._Examining the genetic_characteristics of subjects with_pubertal disorders will_reveal_insights into the mechanisms underlying the reawakening of the hypothalamic-pituitary-gonadal axis at puberty. This_will_provide"}
{"text": " demonstrable in many cell types. Reconstitution with exogenous Gαi2 or other isoforms did not significantly rectify the chemotaxis defect. Unlike Nef induced loss, siRNA mediated Gαi2 KD did not diminish CXCL12 dependent signaling or alter CXCR4 expression. By degrading", "synonym_substitution": "demonstrable in many cell types. Reconstitution with exogenous Gαi2 or other isoforms did not significantly correct the chemotaxis blemish. Unlike Nef induced loss, siRNA intercede Gαi2 KD did not decrease CXCL12 dependent signaling or alter CXCR4 saying. By degrading", "butter_fingers": " delonstrable in many cell uypes. Reconstitutnin witi exogehous Gαi2 ur other isoforms did not sijnifucantoy rectify the chemotabis defecn. Unlike Bef mnduced loss, siRIZ mediabzd Gαi2 ND dnd not diminish GXCL12 dependant signaling mr apter CXCR4 expression. By degrading", "random_deletion": "demonstrable in many cell types. Reconstitution with or isoforms did significantly rectify the loss, mediated Gαi2 KD not diminish CXCL12 signaling or alter CXCR4 expression. By", "change_char_case": " demonstrable in many cell typEs. ReconstiTutioN wiTh eXoGenoUs Gαi2 Or other isoformS Did nOt significantly rectify The chEmOTaxiS DeFect. UNlike NeF InDUCed LoSs, SiRnA MEdIated gαi2 Kd did not Diminish CXcL12 dEpEndent signalINg Or alter CXCr4 exPression. By deGraDing", "whitespace_perturbation": " demonstrable in many cell  types. Re const itu tio nwith  exo genous Gα i 2 or  other isoforms did no t sig ni f ican t ly  rect ify the ch e m ota xi sdef ec t .Unlik e N ef indu ced loss,siR NA  mediated G& # 94 5;i2 KD di d n ot diminishCXC L12 de pe nde n t sig nal ing o r alte r  CXCR4  expressi on .  By de g rading", "underscore_trick": " demonstrable_in many_cell types. Reconstitution with_exogenous Gαi2_or_other isoforms_did_not significantly rectify_the chemotaxis defect._Unlike Nef induced loss,_siRNA mediated Gαi2_KD_did not diminish CXCL12 dependent signaling or alter CXCR4 expression. By degrading"}
{"text": " patients have contracted T(CM) compartments and a defect in effector cell development, defects that persist even following clearance of infection. The fact that these global changes in memory and effector cell compartments do not yet occur in infected children makes early treatment of LF even more crucial. Beyond the APC dysfunction, T cells from patients with patent", "synonym_substitution": "patients have contracted T(CM) compartments and a defect in effecter cellular telephone exploitation, defects that prevail even postdate clearance of infection. The fact that these ball-shaped changes in memory and effector cell compartment do not yet occur in infect children makes early discussion of LF even more crucial. Beyond the APC dysfunction, T cells from patients with patent", "butter_fingers": " pahients have contracted T(GM) compartments cbd a dxfect ih effectur cell development, defects vhat persust even following clexrance of infectiin. Tie fact that these global chanfcs in nemory and effgctor cell cmmpartments do nut yet occur in infected children makqs earlu hreatment of LS evtn iore brmcial. Beyond the APC dysfunction, T cellv from patienys with patent", "random_deletion": "patients have contracted T(CM) compartments and a effector development, defects persist even following that global changes in and effector cell do not yet occur in infected makes early treatment of LF even more crucial. Beyond the APC dysfunction, T from patients with patent", "change_char_case": " patients have contracted T(CM) CompartmenTs and A deFecT iN effEctoR cell developmeNT, defEcts that persist even folLowinG cLEaraNCe Of infEction. THE fACT thAt ThEse GlOBaL chanGes In memorY and effectOr cElL compartmentS Do Not yet occuR in Infected chilDreN makes EaRly TReatmEnt Of LF eVen morE CruciaL. Beyond thE Apc dysfuNCtion, T cELLs From Patients with patenT", "whitespace_perturbation": " patients have contractedT(CM) comp artme nts  an da de fect  in effector c e ll d evelopment, defects th at pe rs i st e v en  foll owing c l ea r a nce  o finf ec t io n. Th e f act tha t these gl oba lchanges in m e mo ry and eff ect or cell comp art mentsdo  no t  yetocc ur in  infec t ed chi ldren mak es earlyt reatmen t of  LFeven more crucial .  B e yond the APC d ysfunc ti o n, T  ce lls  from pati en ts wi t h paten t ", "underscore_trick": " patients_have contracted_T(CM) compartments and a_defect in_effector_cell development,_defects_that persist even_following clearance of_infection. The fact that_these global changes_in_memory and effector cell compartments do not yet occur in infected children makes early_treatment_of LF_even_more_crucial. Beyond the APC dysfunction,_T cells from patients with_patent"}
{"text": " significantly lower compared to that in ETV-receiving mice (p0.0001). We finally analyzed the structural interactions of ETV-TP and CMCP-TP with reverse transcriptase (RT) of HBVWT. There are multiple strong polar interactions between CMCP-TP and the reverse transcriptase. The amino", "synonym_substitution": "significantly lower compared to that in ETV - receiving mouse (p0.0001). We ultimately analyzed the structural interactions of ETV - TP and CMCP - TP with inverse transcriptase (RT) of HBVWT. There are multiple strong diametric interactions between CMCP - TP and the reverse transcriptase. The amino", "butter_fingers": " sihnificantly lower compartd to that in ETV-texeivinj mice (l0.0001). We finxlly analyzed the structural ibteraxtions of ETV-TP and CMZP-TP with reverse traiscriptase (RT) of HBVWT. Tmzre adc mulci'le strong polat interactiots between CMC[-TO cnd the reverse transcriptase. The amyno", "random_deletion": "significantly lower compared to that in ETV-receiving We analyzed the interactions of ETV-TP (RT) HBVWT. There are strong polar interactions CMCP-TP and the reverse transcriptase. The", "change_char_case": " significantly lower compareD to that in EtV-recEivIng MiCe (p0.0001). WE finAlly analyzed thE StruCtural interactions of ETv-TP anD CmcP-TP WItH reveRse tranSCrIPTasE (Rt) oF HBvWt. thEre arE muLtiple sTrong polar IntErActions betweEN CmCP-TP and thE reVerse transcrIptAse. The AmIno", "whitespace_perturbation": " significantly lower compa red to tha t inETV -re ce ivin g mi ce (p0.0001).W e fi nally analyzed the str uctur al inte r ac tions  of ETV - TP a ndCM CP -TP  w i th  reve rse  transc riptase (R T)of  HBVWT. Ther e  a re multipl e s trong polarint eracti on s b e tween  CM CP-TP  and t h e reve rse trans cr i ptase. The ami n o ", "underscore_trick": " significantly_lower compared_to that in ETV-receiving_mice (p0.0001)._We_finally analyzed_the_structural interactions of_ETV-TP and CMCP-TP_with reverse transcriptase (RT)_of HBVWT. There_are_multiple strong polar interactions between CMCP-TP and the reverse transcriptase. The amino"}
{"text": ", several rare phenotypic categories have been described in men with IGD, including adult-onset IHH (Nachtigall, LB, et al, N Engl J Med, 1997) and reversal of the disorder after a period of treatment (Raivio, T, et al, N Engl J Med", "synonym_substitution": ", several rare phenotypic categories have been described in serviceman with IGD, include adult - onset IHH (Nachtigall, LB, et al, N Engl J Med, 1997) and reversal of the disorder after a menstruation of treatment (Raivio, T, et al, N Engl J Med", "butter_fingers": ", segeral rare phenotypic cauegories have beeu descrmbed in men witf IGD, including adult-onset IIH (Nqchtitall, LB, et al, N Engl J Med, 1997) and reversao of rhe disordxd after a perjld oy vreatment (Raivip, T, et al, T Engl J Med", "random_deletion": ", several rare phenotypic categories have been men IGD, including IHH (Nachtigall, LB, Med, and reversal of disorder after a of treatment (Raivio, T, et al, Engl J Med", "change_char_case": ", several rare phenotypic cateGories have Been dEscRibEd In meN witH IGD, including aDUlt-oNset IHH (Nachtigall, LB, et aL, N EngL J mEd, 1997) anD ReVersaL of the dISoRDEr aFtEr A peRiOD oF treaTmeNt (RaiviO, T, et al, N EngL J MEd", "whitespace_perturbation": ", several rare phenotypiccategories  have  be ende scri bedin men with IG D , in cluding adult-onset IH H (Na ch t igal l ,LB, e t al, N En g l  JMe d,  19 97 )  a nd re ver sal ofthe disord eraf ter a period of  treatment  (R aivio, T, et  al , N En gl  JM ed", "underscore_trick": ", several_rare phenotypic_categories have been described_in men_with_IGD, including_adult-onset_IHH (Nachtigall, LB,_et al, N_Engl J Med, 1997)_and reversal of_the_disorder after a period of treatment (Raivio, T, et al, N Engl J Med"}
{"text": " cells (T(EFF)) than did ENs giving significantly smaller T(EFF):T(EM) ratios. These contracted T(CM) and T(EFF) populations were still evident in patients previously mf+ who had cleared their infection (CLInf). These data indicate that filarial-infected", "synonym_substitution": "cells (T(EFF) ) than did ENs giving importantly small T(EFF):T(EM) ratios. These compress T(CM) and T(EFF) population were still evident in affected role previously mf+ who had clear their infection (CLInf). These datum bespeak that filarial - infected", "butter_fingers": " cepls (T(EFF)) than did ENs giying significantly smalner T(ERF):T(EM) ragios. These contracted T(CM) anv T(EDF) pokllations were still exident in patientw prtviously mf+ who hes clearcb thejv infzcvion (CLInf). Thesg data indicdte that filarhau-iufected", "random_deletion": "cells (T(EFF)) than did ENs giving significantly ratios. contracted T(CM) T(EFF) populations were mf+ had cleared their (CLInf). These data that filarial-infected", "change_char_case": " cells (T(EFF)) than did ENs giving SignificanTly smAllEr T(eFf):T(EM) RatiOs. These contracTEd T(Cm) and T(EFF) populations werE stilL eVIdenT In PatieNts prevIOuSLY mf+ WhO hAd cLeAReD theiR inFection (cLInf). These DatA iNdicate that fILaRial-infectEd", "whitespace_perturbation": " cells (T(EFF)) than did E Ns givingsigni fic ant ly  sma ller  T(EFF):T(EM)r atio s. These contracted T( CM) a nd T(EF F )popul ationsw er e sti ll  e vid en t  i n pat ien ts prev iously mf+  wh ohad clearedt he ir infecti on(CLInf). The sedata i nd ica t e tha t f ilari al-inf e cted", "underscore_trick": " cells_(T(EFF)) than_did ENs giving significantly_smaller T(EFF):T(EM)_ratios._These contracted_T(CM)_and T(EFF) populations_were still evident_in patients previously mf+_who had cleared_their_infection (CLInf). These data indicate that filarial-infected"}
{"text": " whether improving basic cognition aided in maintaining functional independence in elders. As to be reported in JAMA (11/12/02), Phase I found strong, broad and durable cognitive ability-specific training effects. The effect sizes were comparable to or greater than the amount of cognitive decline observed in other longitudinal studies, suggesting that the", "synonym_substitution": "whether improving basic cognition aided in maintaining functional independence in elder. As to be report in JAMA (11/12/02), Phase I found strong, broad and durable cognitive ability - specific education effects. The effect sizes were comparable to or capital than the amount of cognitive decline observe in other longitudinal studies, indicate that the", "butter_fingers": " whfther improving basic connition aided in maintamning fhnctionau independence in elders. As vo bw repirted in JAMA (11/12/02), Phase I found stgong, broae anv durable cognitmbe abillcy-spedlfic creining effects. Jhe effect shzes were compdrxbpe to or greater than the amount of cognitovf decline obsetved pn othsg oongitudinal studies, suggestihg that the", "random_deletion": "whether improving basic cognition aided in maintaining in As to reported in JAMA broad durable cognitive ability-specific effects. The effect were comparable to or greater than amount of cognitive decline observed in other longitudinal studies, suggesting that the", "change_char_case": " whether improving basic cognItion aided In maiNtaIniNg FuncTionAl independence IN eldErs. As to be reported in JAMa (11/12/02), PhasE I FOund STrOng, brOad and dURaBLE coGnItIve AbILiTy-speCifIc trainIng effects. the EfFect sizes werE CoMparable to Or gReater than thE amOunt of CoGniTIve deCliNe obsErved iN Other lOngitudinAl STudies, SUggestiNG ThAt thE", "whitespace_perturbation": " whether improving basic c ognition a idedinmai nt aini ng f unctional inde p ende nce in elders. As to b e rep or t ed i n  J AMA ( 11/12/0 2 ), P has eIfou nd st rong,  br oad and  durable c ogn it ive ability- s pe cific trai nin g effects. T heeffect  s ize s  were  co mpara ble to or gre ater than  t h e amou n t of co g n it ivedecline observedi no ther longitudi nal st ud i es , sug ges ting thatth e", "underscore_trick": " whether_improving basic_cognition aided in maintaining_functional independence_in_elders. As_to_be reported in_JAMA (11/12/02), Phase_I found strong, broad_and durable cognitive_ability-specific_training effects. The effect sizes were comparable to or greater than the amount of_cognitive_decline observed_in_other_longitudinal studies, suggesting that the"}
{"text": " are previously unidentified psychological features in need of further investigation. Preliminary results from this pilot study suggest that there is an increase in both anxiety and depression symptoms in the IGD group, and that this can be ascertained by online surveys to improve recruitment. As a result of the phenotyping efforts pioneered by our collaborators at MGH", "synonym_substitution": "are previously unidentified psychological features in need of further investigation. Preliminary result from this pilot burner study suggest that there is an addition in both anxiety and depression symptoms in the IGD group, and that this can be ascertained by on-line surveys to improve recruitment. As a consequence of the phenotyping efforts pioneered by our collaborator at MGH", "butter_fingers": " arf previously unidentifiea psychological featurxs in nsed of fjrther investigation. Prelimiiary resuots from this pilot stjdy suggedt that rhert is an increase mh both anxietg and vepression sympjoms in the HGD group, and dhxt this can be ascertained by online furveys tl improve recroitmeme. As a result of the phenotyping efforfs piontered by our collanorators at MGH", "random_deletion": "are previously unidentified psychological features in need investigation. results from pilot study suggest in anxiety and depression in the IGD and that this can be ascertained online surveys to improve recruitment. As a result of the phenotyping efforts pioneered our collaborators at MGH", "change_char_case": " are previously unidentified PsychologiCal feAtuRes In Need Of fuRther investigaTIon. PReliminary results from tHis piLoT StudY SuGgest That theRE iS AN inCrEaSe iN bOTh AnxieTy aNd depreSsion symptOms In The IGD group, aND tHat this can Be aScertained by OnlIne surVeYs tO ImproVe rEcruiTment. AS A resulT of the pheNoTYping eFForts piONEeRed bY our collaborators AT Mgh", "whitespace_perturbation": " are previously unidentifi ed psychol ogica l f eat ur es i n ne ed of furtheri nves tigation. Preliminaryresul ts from th is pi lot stu d ys u gge st  t hat  t h er e isanincreas e in bothanx ie ty and depre s si on symptom s i n the IGD gr oup , andth att his c anbe as certai n ed byonline su rv e ys toi mprover e cr uitm ent. As a resulto ft he phenotyping  effor ts pi o n eer edby our col la borat o rs at M G H", "underscore_trick": " are_previously unidentified_psychological features in need_of further_investigation._Preliminary results_from_this pilot study_suggest that there_is an increase in_both anxiety and_depression_symptoms in the IGD group, and that this can be ascertained by online surveys_to_improve recruitment._As_a_result of the phenotyping efforts_pioneered by our collaborators at_MGH"}
{"text": " infection have induced pathways that in concert prevent Th1-type T cell activation. We have recently shown that the filarial infection at homeostasis is associated with an expansion of IL-10 producing adaptive Tregs as well as nTregs and that these are associated with the suppression of parasite-antigen induced pro-inflammatory Th", "synonym_substitution": "infection have induced pathways that in concert prevent Th1 - type metric ton cellular telephone activation. We have recently shown that the filarial contagion at homeostasis is associated with an expansion of IL-10 produce adaptive Tregs as well as nTregs and that these are associate with the suppression of parasite - antigen induce pro - inflammatory Th", "butter_fingers": " invection have induced patmways that in couxert pcevent Fh1-type T cell activation. We have recxntlt shoqn that the filarial ivfection wt homeowtasms is associated with an expanalon oy ML-10 producing adsptive Trecs as well as tTfeys and that these are associated witr the siporession of patasitt-aneigeh induced pro-inflammatory Th", "random_deletion": "infection have induced pathways that in concert T activation. We recently shown that is with an expansion IL-10 producing adaptive as well as nTregs and that are associated with the suppression of parasite-antigen induced pro-inflammatory Th", "change_char_case": " infection have induced pathwAys that in cOncerT prEveNt th1-tyPe T cEll activation. WE Have Recently shown that the fiLariaL iNFectIOn At homEostasiS Is ASSocIaTeD wiTh AN eXpansIon Of IL-10 proDucing adapTivE TRegs as well as NtrEgs and that TheSe are associaTed With thE sUppREssioN of ParasIte-antIGen indUced pro-inFlAMmatorY th", "whitespace_perturbation": " infection have induced pa thways tha t incon cer tprev entTh1-type T cel l  act ivation. We have recen tly s ho w n th a tthe f ilarial in f e cti on  a t h om e os tasis  is  associ ated withanex pansion of I L -1 0 producin g a daptive Treg s a s well  a s n T regsand  that  these are as sociatedwi t h thes uppress i o nof p arasite-antigen i n du c ed pro-inflamm atoryTh ", "underscore_trick": " infection_have induced_pathways that in concert_prevent Th1-type_T_cell activation._We_have recently shown_that the filarial_infection at homeostasis is_associated with an_expansion_of IL-10 producing adaptive Tregs as well as nTregs and that these are associated_with_the suppression_of_parasite-antigen_induced pro-inflammatory Th"}
{"text": " they have little intrinsic market value. So, investigators must obtain the key reagents of the assay from R&D suppliers that do not adhere to quality assurance measures required of manufacturers of diagnostic tests that are critical for achieving consistent lot-to-lot content and performance. The SAIC-Frederick clinical PD support program has", "synonym_substitution": "they have little intrinsic market value. So, detective must receive the key reagents of the assay from R&D suppliers that do not stand by to quality assurance measures want of manufacturer of diagnostic tests that are critical for achieve reproducible lot - to - draw content and performance. The SAIC - Frederick clinical PD accompaniment platform has", "butter_fingers": " thfy have little intrinsic market value. So, invesvigatora must octain the key reagents of thx asway feom R&D suppliers that ao not adjere to wualmty assurance meeaures rczuirsf of nanufacturers pf diagnosdic tests that afe critical for achieving consistent jot-to-loy fontent and petformsgce. Fhe SAIC-Frederick clinical PD suppkrt projram has", "random_deletion": "they have little intrinsic market value. So, obtain key reagents the assay from adhere quality assurance measures of manufacturers of tests that are critical for achieving lot-to-lot content and performance. The SAIC-Frederick clinical PD support program has", "change_char_case": " they have little intrinsic maRket value. SO, inveStiGatOrS musT obtAin the key reageNTs of The assay from R&D supplierS that Do NOt adHErE to quAlity asSUrANCe mEaSuRes ReQUiRed of ManUfacturErs of diagnOstIc Tests that are CRiTical for acHieVing consisteNt lOt-to-loT cOntENt and PerFormaNce. The saIC-FreDerick cliNiCAl PD suPPort proGRAm Has", "whitespace_perturbation": " they have little intrinsi c market v alue.  So , i nv esti gato rs must obtain thekey reagents of the as say f ro m  R&D su pplie rs that do n otad he reto qu ality  as surance  measuresreq ui red of manuf a ct urers of d iag nostic tests  th at are  c rit i cal f orachie ving c o nsiste nt lot-to -l o t cont e nt andp e rf orma nce. The SAIC-Fre d er i ck clinical PD  suppo rt pr o g ram  ha s", "underscore_trick": " they_have little_intrinsic market value. So,_investigators must_obtain_the key_reagents_of the assay_from R&D suppliers_that do not adhere_to quality assurance_measures_required of manufacturers of diagnostic tests that are critical for achieving consistent lot-to-lot content_and_performance. The_SAIC-Frederick_clinical_PD support program has"}
{"text": " potential roles at exocytic sites. Through this work we developed a universal map of the proteins that control exocytosis and provide a new global network level analysis of vesicle fusion. We were able to identify unique classes of key regulatory molecules that strongly associate with the vast majority of docked exocytic vesicles in endocrine chromaffin and beta", "synonym_substitution": "potential roles at exocytic sites. Through this work we develop a cosmopolitan map of the proteins that see exocytosis and put up a new global net level analysis of vesicle fusion. We were able to name alone classes of cardinal regulatory molecules that strongly associate with the huge majority of docked exocytic vesicles in hormone chromaffin and beta", "butter_fingers": " pohential roles at exocytig sites. Through jhus worn we dsveloped a universal map of the protxins that control exocytosis ana provide a new goobao network lxbel analysis kn vesncoe fusion. We wgre able to hdentify uniqua zlcsses of key regulatory molecules thwt stromgpy associate wyth uhe vasf majority of docked exocytic vesidles in endocrine chtomaffin and beta", "random_deletion": "potential roles at exocytic sites. Through this developed universal map the proteins that new network level analysis vesicle fusion. We able to identify unique classes of regulatory molecules that strongly associate with the vast majority of docked exocytic vesicles endocrine chromaffin and beta", "change_char_case": " potential roles at exocytic sItes. ThrougH this WorK we DeVeloPed a Universal map of THe prOteins that control exocyTosis AnD ProvIDe A new gLobal neTWoRK LevEl AnAlySiS Of VesicLe fUsion. We Were able to IdeNtIfy unique claSSeS of key reguLatOry molecules ThaT stronGlY asSOciatE wiTh the Vast maJOrity oF docked exOcYTic vesICles in eNDOcRine Chromaffin and beta", "whitespace_perturbation": " potential roles at exocyt ic sites.Throu ghthi swork  wedeveloped a un i vers al map of the proteins  that  c o ntro l  e xocyt osis an d  p r o vid eanew  g l ob al ne two rk leve l analysis  of  v esicle fusio n .We were ab leto identifyuni que cl as ses of ke y r egula tory m o lecule s that st ro n gly as s ociatew i th  the  vast majority of do c ked exocytic v esicle si ne n doc rin e chromaff in  andb eta", "underscore_trick": " potential_roles at_exocytic sites. Through this_work we_developed_a universal_map_of the proteins_that control exocytosis_and provide a new_global network level_analysis_of vesicle fusion. We were able to identify unique classes of key regulatory molecules_that_strongly associate_with_the_vast majority of docked exocytic_vesicles in endocrine chromaffin and_beta"}
{"text": " of the pancreatic islets. Along with these studies we have developed a new super-resolution correlative light and electron microscopy method (CLEM). This CLEM method allows us to image the location of identified proteins in the nano-scale structural context of the cellular environment. Specifically, we have succeeded in developing a robust pipeline for", "synonym_substitution": "of the pancreatic islets. Along with these studies we have developed a new ace - settlement correlative light and electron microscopy method (CLEM). This CLEM method acting allows us to visualize the location of identified protein in the nano - scale structural context of the cellular environment. Specifically, we have succeeded in develop a robust pipeline for", "butter_fingers": " of the pancreatic islets. Auong with these studiev we hzve deveuoped a new super-resolution rorrwlatice light and electron oicroscopj method (XLEM). Rhis CLEM method allows hd to mmage the locatlon of idendified proteinv kn the nano-scale structural context os the crlpular environmgnt. Skecyficzlly, we have succeeded in developihg a rouust pipeline fpr", "random_deletion": "of the pancreatic islets. Along with these have a new correlative light and CLEM allows us to the location of proteins in the nano-scale structural context the cellular environment. Specifically, we have succeeded in developing a robust pipeline for", "change_char_case": " of the pancreatic islets. AlonG with these StudiEs wE haVe DeveLopeD a new super-resoLUtioN correlative light and elEctroN mICrosCOpY methOd (CLEM). THIs cleM mEtHoD alLoWS uS to imAge The locaTion of idenTifIeD proteins in tHE nAno-scale stRucTural context Of tHe cellUlAr eNVironMenT. SpecIficalLY, we havE succeedeD iN DeveloPIng a robUST pIpelIne for", "whitespace_perturbation": " of the pancreatic islets.  Along wit h the sestu di es w e ha ve developed a newsuper-resolution corre lativ el ight an d ele ctron m i cr o s cop yme tho d( CL EM).Thi s CLEMmethod all ows  u s to image t h elocation o f i dentified pr ote ins in  t hen ano-s cal e str uctura l  conte xt of the  c e llular environ m e nt . Sp ecifically, we ha v es ucceeded in de velopi ng ar o bus t p ipeline fo r", "underscore_trick": " of_the pancreatic_islets. Along with these_studies we_have_developed a_new_super-resolution correlative light_and electron microscopy_method (CLEM). This CLEM_method allows us_to_image the location of identified proteins in the nano-scale structural context of the cellular_environment._Specifically, we_have_succeeded_in developing a robust pipeline_for"}
{"text": " of the polymer concentration and the calcium ion content, and is close to the value of the DNA double helix (10 A). This finding implies that bundle formation is negligible in the present DNA gels. The results of this study show that changes in the ionic environment offer a molecular level control of the interactions between DNA strands and allow", "synonym_substitution": "of the polymer concentration and the calcium ion content, and is close to the value of the DNA bivalent coil (10 ampere). This finding implies that bundle geological formation is negligible in the present DNA gels. The resultant role of this sketch show that deepen in the ionic environment offer a molecular level command of the interactions between DNA strand and admit", "butter_fingers": " of the polymer concentratiun and the calcnym ion conteht, and ir close to the value of the VNA eoublt helix (10 A). This finaing implpes that vundow formatioi is negligibls in chx present DNA ggls. The resunts of this stgdh dhow that changes in the ionic enviwonment ovfer a moleculwr ltvej cohnril of the interactions betweeh DNA surands and allow", "random_deletion": "of the polymer concentration and the calcium and close to value of the This implies that bundle is negligible in present DNA gels. The results of study show that changes in the ionic environment offer a molecular level control the interactions between DNA strands and allow", "change_char_case": " of the polymer concentration And the calcIum ioN coNteNt, And iS cloSe to the value of THe DNa double helix (10 A). This findiNg impLiES thaT BuNdle fOrmatioN Is NEGliGiBlE in ThE PrEsent dNA Gels. The Results of tHis StUdy show that cHAnGes in the ioNic Environment oFfeR a moleCuLar LEvel cOntRol of The intERactioNs between dNa StrandS And alloW", "whitespace_perturbation": " of the polymer concentrat ion and th e cal ciu m i on  con tent , and is close to t he value of the DNA do ublehe l ix ( 1 0A). T his fin d in g imp li es  th at bu ndlefor mationis negligi ble  i n the presen t  D NA gels. T heresults of t his  study  s how thatcha ngesin the ionicenvironme nt offera  molecu l a rleve l control of thei nt e ractions betwe en DNA  s t ra n d s a ndallow", "underscore_trick": " of_the polymer_concentration and the calcium_ion content,_and_is close_to_the value of_the DNA double_helix (10 A). This_finding implies that_bundle_formation is negligible in the present DNA gels. The results of this study show_that_changes in_the_ionic_environment offer a molecular level_control of the interactions between_DNA strands_and allow"}
{"text": " segment of this region. As a further test, we subdivided the 540 kb ED4065 deletion and the 389 kb ED2247 deletion. In both cases, dosage sensitivity could be recapitulated by a 50 kb deletion. In each of these regions, is a single gene responsible for the anesthesia phenotype? Our test", "synonym_substitution": "segment of this region. As a further test, we subdivided the 540 kilobyte ED4065 omission and the 389 kb ED2247 deletion. In both lawsuit, dose sensitivity could be recapitulated by a 50 kb omission. In each of these regions, is a single gene responsible for the anesthesia phenotype? Our trial", "butter_fingers": " sehment of this region. As x further test, cw subdmvided fhe 540 kb DD4065 deletion and the 389 kb ED2247 dxletuon. Ib both cases, dosage sevsitivity could bw rerapitulated by a 50 kb delccion. Jk eack if these regioks, is a sincle gene respotskbpe for the anesthesia phenotype? Our test", "random_deletion": "segment of this region. As a further subdivided 540 kb deletion and the both dosage sensitivity could recapitulated by a kb deletion. In each of these is a single gene responsible for the anesthesia phenotype? Our test", "change_char_case": " segment of this region. As a furTher test, we SubdiVidEd tHe 540 Kb ED4065 DeleTion and the 389 kb ED2247 DEletIon. In both cases, dosage seNsitiViTY couLD bE recaPitulatED bY A 50 Kb dElEtIon. in EAcH of thEse Regions, Is a single gEne ReSponsible for THe Anesthesia PheNotype? Our tesT", "whitespace_perturbation": " segment of this region. A s a furthe r tes t,wesu bdiv ided  the 540 kb ED 4 065deletion and the 389 k b ED2 24 7  del e ti on. I n bothc as e s , d os ag e s en s it ivity  co uld berecapitula ted  b y a 50 kb de l et ion. In ea chof these reg ion s, isasin g le ge nerespo nsible for th e anesthe si a  pheno t ype? Ou r te st", "underscore_trick": " segment_of this_region. As a further_test, we_subdivided_the 540_kb_ED4065 deletion and_the 389 kb_ED2247 deletion. In both_cases, dosage sensitivity_could_be recapitulated by a 50 kb deletion. In each of these regions, is a_single_gene responsible_for_the_anesthesia phenotype? Our test"}
{"text": "-NETs originate from a subset of EC cells (reserve EC cells that express reserve ISC genes) via multifocal and polyclonal processes. The epithelium of the small intestine renews itself every 3-5 days as a result of actively cycling intestinal stem cells ISCs residing at the crypt base. Most recently, we", "synonym_substitution": "-NETs originate from a subset of EC cells (reserve EC cells that express reservation ISC gene) via multifocal and polyclonal processes. The epithelium of the small intestine regenerate itself every 3 - 5 day as a result of actively cycling intestinal bow cell ISCs residing at the crypt foundation. Most recently, we", "butter_fingers": "-NETd originate from a subseu of EC cells (resgrce EC rells tgat exprdss reserve ISC genes) via muptufocao and polyclonal procerses. The vpitheliun of rhe small mhtestinc rensas icsxlf every 3-5 days as a resunt of actively chcping intestinal stem cells ISCs resyding ay hhe crypt base. Mosu rqcenfly, we", "random_deletion": "-NETs originate from a subset of EC EC that express ISC genes) via epithelium the small intestine itself every 3-5 as a result of actively cycling stem cells ISCs residing at the crypt base. Most recently, we", "change_char_case": "-NETs originate from a subset oF EC cells (reServe eC cEllS tHat eXpreSs reserve ISC geNEs) viA multifocal and polyclonAl proCeSSes. THE ePitheLium of tHE sMALl iNtEsTinE rENeWs itsElf Every 3-5 daYs as a resulT of AcTively cyclinG InTestinal stEm cElls ISCs resiDinG at the CrYpt BAse. MoSt rEcentLy, we", "whitespace_perturbation": "-NETs originate from a sub set of ECcells  (r ese rv e EC  cel ls that expres s  res erve ISC genes) via mu ltifo ca l  and po lyclo nal pro c es s e s.Th eepi th e li um of  th e small  intestine  re ne ws itself ev e ry  3-5 daysasa result ofact ivelycy cli n g int est inalstem c e lls IS Cs residi ng at the crypt b a s e.  Mos t recently, we", "underscore_trick": "-NETs originate_from a_subset of EC cells_(reserve EC_cells_that express_reserve_ISC genes) via_multifocal and polyclonal_processes. The epithelium of_the small intestine_renews_itself every 3-5 days as a result of actively cycling intestinal stem cells ISCs_residing_at the_crypt_base._Most recently, we"}
{"text": ", and 23 nM to block HBV DNA synthesis in HepG2.2.2.15.7 cells for ETV, CdG, and CMCP, respectively. We further examined the effects of CMCP on cellular mitochondrial DNA (mtDNA), cell growth, and cell viability using MOLT-4 and D", "synonym_substitution": ", and 23 nM to block HBV DNA synthesis in HepG2.2.2.15.7 cells for ETV, CdG, and CMCP, respectively. We further probe the effect of CMCP on cellular mitochondrial DNA (mtDNA), cell growth, and cell viability use MOLT-4 and D", "butter_fingers": ", anf 23 nM to block HBV DNA snnthesis in HepG2.2.2.15.7 cells hor ETV, CdG, and CMCP, respectively. We furthec exqminee the effects of CMCP un cellulwr mitocyondcial DNA (mtDNA), cxml growbk, and gell riebility using MPLT-4 and D", "random_deletion": ", and 23 nM to block HBV in cells for CdG, and CMCP, effects CMCP on cellular DNA (mtDNA), cell and cell viability using MOLT-4 and", "change_char_case": ", and 23 nM to block HBV DNA synthesIs in HepG2.2.2.15.7 ceLls foR ETv, Cdg, aNd CMcP, reSpectively. We fuRTher Examined the effects of CMcP on cElLUlar MItOchonDrial DNa (Mtdna), ceLl GrOwtH, aND cEll viAbiLity usiNg MOLT-4 and D", "whitespace_perturbation": ", and 23 nM to block HBV D NA synthes is in  He pG2 .2 .2.1 5.7cells for ETV, CdG,  and CMCP, respectivel y. We  f u rthe r  e xamin ed thee ff e c tsof  C MCP  o n  c ellul armitocho ndrial DNA  (m tD NA), cell gr o wt h, and cel l v iability usi ngMOLT-4  a ndD ", "underscore_trick": ", and_23 nM_to block HBV DNA_synthesis in_HepG2.2.2.15.7_cells for_ETV,_CdG, and CMCP,_respectively. We further_examined the effects of_CMCP on cellular_mitochondrial_DNA (mtDNA), cell growth, and cell viability using MOLT-4 and D"}
{"text": " it is highly likely that excellent hypotheses about human endocrine disruption will arise, and that the NCS should be designed to accommodate as many such possibilities as is feasible. We reviewed the epidemiologic data that addressed whether environmental contaminants might cause type 1 or type 2 diabetes. For type 1 diabetes, higher intake of nitrates, nit", "synonym_substitution": "it is highly likely that excellent hypotheses about human endocrine disruption will rebel, and that the NCS should be design to accommodate as many such possibilities as is feasible. We reviewed the epidemiologic datum that addressed whether environmental contaminants might cause character 1 or character 2 diabetes. For type 1 diabetes, higher intake of nitrates, nit", "butter_fingers": " it is highly likely that ewcellent hypotheses abont humah endocrkne disruption will arise, anv thqt tht NCS should be deskgned to wccommodqte es many such possibiliticf as ls fecsmble. We reviewec the epidamiologic data tfac addressed whether environmental cogtaminamtd might cause jype 1 jr tgie 2 diabetes. For type 1 diabetes, higher intake of niyrates, nit", "random_deletion": "it is highly likely that excellent hypotheses endocrine will arise, that the NCS as such possibilities as feasible. We reviewed epidemiologic data that addressed whether environmental might cause type 1 or type 2 diabetes. For type 1 diabetes, higher of nitrates, nit", "change_char_case": " it is highly likely that excelLent hypothEses aBouT huMaN endOcriNe disruption wiLL ariSe, and that the NCS should bE desiGnED to aCCoMmodaTe as manY SuCH PosSiBiLitIeS As Is feaSibLe. We revIewed the epIdeMiOlogic data thAT aDdressed whEthEr environmenTal ContamInAntS Might CauSe typE 1 or typE 2 DiabetEs. For type 1 DiABetes, hIGher intAKE oF nitRates, nit", "whitespace_perturbation": " it is highly likely thatexcellenthypot hes esab outhuma n endocrine di s rupt ion will arise, and th at th eN CS s h ou ld be  design e dt o  ac co mm oda te as  many  su ch poss ibilitiesasis  feasible. W e  r eviewed th e e pidemiologic  da ta tha tadd r essed  wh ether  envir o nmenta l contami na n ts mig h t cause t yp e 1or type 2 diabete s .F or type 1 diab etes,hi g he r int ake  of nitrat es , nit ", "underscore_trick": " it_is highly_likely that excellent hypotheses_about human_endocrine_disruption will_arise,_and that the_NCS should be_designed to accommodate as_many such possibilities_as_is feasible. We reviewed the epidemiologic data that addressed whether environmental contaminants might cause_type_1 or_type_2_diabetes. For type 1 diabetes,_higher intake of nitrates, nit"}
{"text": " revealed two characteristic length scales, the mesh size of the transient network, and the cross-sectional radius of the DNA double helix. In gels the mesh size is greater than in the corresponding solutions by approximately 50%, reflecting the increased heterogeneity of the crosslinked system. The cross-sectional radius of the DNA chain is practically independent", "synonym_substitution": "revealed two characteristic length scales, the mesh size of the transeunt net, and the cross - sectional radius of the DNA bivalent helix. In gelatin the mesh size is greater than in the match solutions by approximately 50% , reflecting the increase heterogeneity of the crosslinked system. The cross - sectional spoke of the DNA chain is practically independent", "butter_fingers": " regealed two characteristig length scales, jhw mesh size kf the tfansient network, and the crods-wectiinal radius of the DNA double hvlix. In gwls uhe mesh size is jdeater bkan ih the rorresponding splutions bf approximatelf 50%, rzflecting the increased heterogeneitr of thr frosslinked syftem. Ehe dgows-sectional radius of the DNA chain ps practically incependent", "random_deletion": "revealed two characteristic length scales, the mesh the network, and cross-sectional radius of gels mesh size is than in the solutions by approximately 50%, reflecting the heterogeneity of the crosslinked system. The cross-sectional radius of the DNA chain is independent", "change_char_case": " revealed two characteristic Length scalEs, the MesH siZe Of thE traNsient network, aND the Cross-sectional radius of The DNa dOUble HElIx. In gEls the mESh SIZe iS gReAteR tHAn In the CorRespondIng solutioNs bY aPproximately 50%, REfLecting the IncReased heteroGenEity of ThE crOSslinKed SysteM. The crOSs-sectIonal radiUs OF the DNa Chain is PRAcTicaLly independent", "whitespace_perturbation": " revealed two characterist ic lengthscale s,the  m eshsize  of the transi e nt n etwork, and the cross- secti on a l ra d iu s ofthe DNA do u b lehe li x.In ge ls th e m esh siz e is great erth an in the co r re sponding s olu tions by app rox imatel y50% ,  refl ect ing t he inc r easedheterogen ei t y of t h e cross l i nk ed s ystem. The cross- s ec t ional radius o f theDN A  c h a inispracticall yindep e ndent", "underscore_trick": " revealed_two characteristic_length scales, the mesh_size of_the_transient network,_and_the cross-sectional radius_of the DNA_double helix. In gels_the mesh size_is_greater than in the corresponding solutions by approximately 50%, reflecting the increased heterogeneity of_the_crosslinked system._The_cross-sectional_radius of the DNA chain_is practically independent"}
{"text": " converting enzyme (TACE, ADAM17) cleaves membrane-associated cytokines and receptors and thereby regulates inflammatory and immune events, as well as lung development and mucin production. TACE is synthesized as a latent pro-enzyme that is retained in an inactive state via an interaction between its pro-domain and catalytic domain", "synonym_substitution": "converting enzyme (TACE, ADAM17) cleaves membrane - associated cytokines and receptors and thereby determine incendiary and immune events, as well as lung growth and mucin output. TACE is synthesized as a latent pro - enzyme that is retain in an dormant state via an interaction between its pro - domain and catalytic domain", "butter_fingers": " cojverting enzyme (TACE, ADAO17) cleaves membrcbe-assoriated dytokiner and receptors and thereby ceguoates inflammatory and immuve events, as well as oyng develo'jent and mucih proburtion. TACE is sinthesized av a latent pro-anxyle that is retained in an inactive ftate voa an interactiog beuweqn ifs pro-domain and catalytic domain", "random_deletion": "converting enzyme (TACE, ADAM17) cleaves membrane-associated cytokines and regulates inflammatory immune events, as mucin TACE is synthesized a latent pro-enzyme is retained in an inactive state an interaction between its pro-domain and catalytic domain", "change_char_case": " converting enzyme (TACE, ADAM17) cLeaves membRane-aSsoCiaTeD cytOkinEs and receptors ANd thEreby regulates inflammaTory aNd IMmunE EvEnts, aS well as LUnG DEveLoPmEnt AnD MuCin prOduCtion. TAcE is syntheSizEd As a latent pro-ENzYme that is rEtaIned in an inacTivE state ViA an INteraCtiOn betWeen itS Pro-domAin and catAlYTic domAIn", "whitespace_perturbation": " converting enzyme (TACE,ADAM17) cl eaves  me mbr an e-as soci ated cytokines andreceptors and therebyregul at e s in f la mmato ry andi mm u n e e ve nt s,as we ll as  lu ng deve lopment an d m uc in productio n .TACE is sy nth esized as alat ent pr o- enz y me th atis re tained in aninactivest a te via an inte r a ct ionbetween its pro-d o ma i n and catalyti c doma in ", "underscore_trick": " converting_enzyme (TACE,_ADAM17) cleaves membrane-associated cytokines_and receptors_and_thereby regulates_inflammatory_and immune events,_as well as_lung development and mucin_production. TACE is_synthesized_as a latent pro-enzyme that is retained in an inactive state via an interaction_between_its pro-domain_and_catalytic_domain"}
{"text": " extracts from parasitized erythrocytes, binding to immobilized aptamers, and identification of target molecules by mass spectrometry. However, we now have bands on SDS-PAGE gels and are confident we will have identification of target molecules. Using our standardized blood-stage parasite growth inhibition assay (GIA), we have collaborated with others in", "synonym_substitution": "extracts from parasitized erythrocytes, binding to immobilized aptamers, and identification of prey molecule by mass spectrometry. However, we now own bands on SDS - PAGE gelatin and are convinced we will have identification of target molecules. Using our exchangeable blood - stage parasite growth prohibition assay (GIA), we have collaborated with others in", "butter_fingers": " exhracts from parasitized trythrocytes, bindnbg to mmmobiljzed aptxmers, and identification of vargwt mooecules by mass spectrumetry. Hoaever, we now yave bands on SDS-PAGE gemd anb ere confident wg will have hdentification ow carget molecules. Using our standardised blopd-dtage parasite groeeh ihhibition assay (GIA), we have collabkrated xith others in", "random_deletion": "extracts from parasitized erythrocytes, binding to immobilized identification target molecules mass spectrometry. However, SDS-PAGE and are confident will have identification target molecules. Using our standardized blood-stage growth inhibition assay (GIA), we have collaborated with others in", "change_char_case": " extracts from parasitized erYthrocytes, BindiNg tO imMoBiliZed aPtamers, and idenTIficAtion of target molecules By masS sPEctrOMeTry. HoWever, we NOw HAVe bAnDs On SdS-paGe gels And Are confIdent we wilL haVe IdentificatiON oF target molEcuLes. Using our sTanDardizEd BloOD-stagE paRasitE growtH InhibiTion assay (gIa), We have COllaborATEd With Others in", "whitespace_perturbation": " extracts from parasitized  erythrocy tes,bin din gto i mmob ilized aptamer s , an d identification of ta rgetmo l ecul e sby ma ss spec t ro m e try .Ho wev er ,  w e now  ha ve band s on SDS-P AGE  g els and arec on fident wewil l have ident ifi cation  o f t a rgetmol ecule s. Usi n g ourstandardi ze d  blood - stage p a r as itegrowth inhibition as s ay (GIA), we h ave co ll a bo r a ted  wi th othersin ", "underscore_trick": " extracts_from parasitized_erythrocytes, binding to immobilized_aptamers, and_identification_of target_molecules_by mass spectrometry._However, we now_have bands on SDS-PAGE_gels and are_confident_we will have identification of target molecules. Using our standardized blood-stage parasite growth inhibition_assay_(GIA), we_have_collaborated_with others in"}
{"text": " antigenic and sequence analysis of these as a prelude to their evaluation for attenuation and safety in non-human primates as potential vectors. Complete sequences have been determined for representatives of APMV2, 3, 4, 7, 8, and 9. In some cases, complete sequences are available for more than one strain", "synonym_substitution": "antigenic and sequence analysis of these as a prelude to their evaluation for attenuation and safety in non - human archpriest as likely vectors. Complete sequence have been determine for representatives of APMV2, 3, 4, 7, 8, and 9. In some cases, arrant succession are available for more than one strain", "butter_fingers": " anhigenic and sequence anauysis of these cw a prxlude tk their dvaluation for attenuation aid sqfety in non-human primates xs potentpal vectoes. Cinplete seqnsnces have besk detzrnined for reprgsentatives mf APMV2, 3, 4, 7, 8, ang 9. Iu some cases, complete sequences are wvailabke for more than one ftrajn", "random_deletion": "antigenic and sequence analysis of these as to evaluation for and safety in Complete have been determined representatives of APMV2, 4, 7, 8, and 9. In cases, complete sequences are available for more than one strain", "change_char_case": " antigenic and sequence analySis of these As a prEluDe tO tHeir EvalUation for attenUAtioN and safety in non-human prImateS aS PoteNTiAl vecTors. ComPLeTE SeqUeNcEs hAvE BeEn detErmIned for RepresentaTivEs Of APMV2, 3, 4, 7, 8, and 9. In sOMe Cases, complEte Sequences are AvaIlable FoR moRE than One StraiN", "whitespace_perturbation": " antigenic and sequence an alysis ofthese  as  apr elud e to  their evaluat i on f or attenuation and saf ety i nn on-h u ma n pri mates a s  p o t ent ia lvec to r s.  Comp let e seque nces havebee ndetermined f o rrepresenta tiv es of APMV2,  3,  4, 7,  8 , a n d 9.Insomecases, comple te sequen ce s  are a v ailable f or  mor e than one strain ", "underscore_trick": " antigenic_and sequence_analysis of these as_a prelude_to_their evaluation_for_attenuation and safety_in non-human primates_as potential vectors. Complete_sequences have been_determined_for representatives of APMV2, 3, 4, 7, 8, and 9. In some cases, complete_sequences_are available_for_more_than one strain"}
{"text": " perpendicular orientation to the leading edge, resulting in its accumulation specifically in focal adhesions. To determine the role of Ser 1916 phosphorylation on myosin IIA dynamics and localization, we expressed phospho-mimetic (S1916D) and non-phosphorylatable mutants (S1916A) of myosin IIA.", "synonym_substitution": "perpendicular orientation to the leading edge, result in its accretion specifically in focal adhesions. To determine the role of Ser 1916 phosphorylation on myosin IIA moral force and localization, we expressed phospho - mimetic (S1916D) and non - phosphorylatable mutants (S1916A) of myosin IIA.", "butter_fingers": " pegpendicular orientation uo the leading edyw, resunting jn its azcumulation specifically in hocao adhtfions. To determine the role of Ser 1916 phowphorylatioi on myosin IIZ dyncmmcs and localizstion, we efpressed phospvo-oiletic (S1916D) and non-phosphorylatable mueants (S1916S) lf myosin IIA.", "random_deletion": "perpendicular orientation to the leading edge, resulting accumulation in focal To determine the on IIA dynamics and we expressed phospho-mimetic and non-phosphorylatable mutants (S1916A) of myosin", "change_char_case": " perpendicular orientation tO the leadinG edge, ResUltInG in iTs acCumulation specIFicaLly in focal adhesions. To dEtermInE The rOLe Of Ser 1916 PhosphoRYlATIon On MyOsiN Iia dYnamiCs aNd localIzation, we eXprEsSed phospho-miMEtIc (S1916D) and non-PhoSphorylatablE muTants (S1916a) oF myOSin IIa.", "whitespace_perturbation": " perpendicular orientation  to the le ading  ed ge,  r esul ting  in its accumu l atio n specifically in foca l adh es i ons. To  dete rmine t h er o leof  S er19 1 6phosp hor ylation  on myosin  II Adynamics and lo calization , w e expressedpho spho-m im eti c  (S19 16D ) and  non-p h osphor ylatablemu t ants ( S 1916A)o f  m yosi n IIA.", "underscore_trick": " perpendicular_orientation to_the leading edge, resulting_in its_accumulation_specifically in_focal_adhesions. To determine_the role of_Ser 1916 phosphorylation on_myosin IIA dynamics_and_localization, we expressed phospho-mimetic (S1916D) and non-phosphorylatable mutants (S1916A) of myosin IIA."}
{"text": " IL-1. These findings explain our clinical findings that bone lesions once they have developed are non responsive to IL-1 blocking lessons. 4. In collaboration with Dr Nishikomoris group in Kyoto a number of our mutation negative patients analyzed by conventional methods are found to have somatic mosaicism. DIRA", "synonym_substitution": "IL-1. These findings explain our clinical findings that bone lesions once they have develop are not responsive to IL-1 blocking moral. 4. In collaboration with Dr Nishikomoris group in Kyoto a phone number of our mutation negative affected role analyze by conventional method are found to have bodily mosaicism. DIRA", "butter_fingers": " IL-1. These findings explain uur clinical fiueings vhat bohe lesiovs once they have developed ere bon rtfponsive to IL-1 blozking lesdons. 4. In coloqboration xjth Dr Knshikkloriv group in Kyotp a number of our mutatimn nzgative patients analyzed by conventyonal mrtjods are found to nwve aomatic mosaicism. DIRA", "random_deletion": "IL-1. These findings explain our clinical findings lesions they have are non responsive In with Dr Nishikomoris in Kyoto a of our mutation negative patients analyzed conventional methods are found to have somatic mosaicism. DIRA", "change_char_case": " IL-1. These findings explain our Clinical fiNdingS thAt bOnE lesIons Once they have deVElopEd are non responsive to IL-1 BlockInG LessONs. 4. in colLaboratIOn WITh DR NIsHikOmORiS grouP in kyoto a nUmber of our MutAtIon negative pATiEnts analyzEd bY conventionaL meThods aRe FouND to haVe sOmatiC mosaiCIsm. DIRa", "whitespace_perturbation": " IL-1. These findings expl ain our cl inica l f ind in gs t hatbone lesions o n ce t hey have developed are  nonre s pons i ve  to I L-1 blo c ki n g  le ss on s.4. In  coll abo rationwith Dr Ni shi ko moris groupi nKyoto a nu mbe r of our mut ati on neg at ive patie nts  anal yzed b y  conve ntional m et h ods ar e  foundt o  h avesomatic mosaicism .  D I RA", "underscore_trick": " IL-1._These findings_explain our clinical findings_that bone_lesions_once they_have_developed are non_responsive to IL-1_blocking lessons. 4. In_collaboration with Dr_Nishikomoris_group in Kyoto a number of our mutation negative patients analyzed by conventional methods_are_found to_have_somatic_mosaicism. DIRA"}
{"text": ". In addition, we have partnered with collaborators at the University of Texas Health Sciences Center on Project MATCH in which we aim to understand the social, cultural, and genomic factors associated with health behaviors in adolescents of Mexican heritage. Several papers examining the role of such factors in physical activity and tobacco use were published during the current", "synonym_substitution": ". In addition, we have partnered with collaborators at the University of Texas Health Sciences Center on Project MATCH in which we aim to sympathize the social, cultural, and genomic divisor associated with health behaviors in adolescent of Mexican heritage. respective papers examining the function of such factors in physical action and tobacco use were published during the current", "butter_fingers": ". In addition, we have partneved with collabotarors av the Uhiversith of Texas Health Sciences Cxntee on Kgoject MATCH in which we aim tl undersrand rhe social, cultural, and fcnomie hactors associajed with heanth behaviors hn abolescents of Mexican heritage. Severwl papets examining the rolt os sudh factors in physical activity ans tobacbo use were publixhed during the current", "random_deletion": ". In addition, we have partnered with the of Texas Sciences Center on aim understand the social, and genomic factors with health behaviors in adolescents of heritage. Several papers examining the role of such factors in physical activity and use were published during the current", "change_char_case": ". In addition, we have partnered With collabOratoRs aT thE UNiveRsitY of Texas Health sCienCes Center on Project MATCh in whIcH We aiM To UnderStand thE SoCIAl, cUlTuRal, AnD GeNomic FacTors assOciated witH heAlTh behaviors iN AdOlescents oF MeXican heritagE. SeVeral pApErs EXaminIng The roLe of suCH factoRs in physiCaL ActiviTY and tobACCo Use wEre published durinG ThE Current", "whitespace_perturbation": ". In addition, we have par tnered wit h col lab ora to rs a t th e University o f  Tex as Health Sciences Cen ter o nP roje c tMATCH  in whi c hw e  ai mto  un de r st and t hesocial,  cultural,  an dgenomic fact o rs  associate d w ith health b eha viorsin  ad o lesce nts  of M exican herita ge. Sever al papers examini n g  t he r ole of such facto r si n physical act ivityan d  t o b acc o u se were pu bl ished duringt he c u rre n t", "underscore_trick": ". In_addition, we_have partnered with collaborators_at the_University_of Texas_Health_Sciences Center on_Project MATCH in_which we aim to_understand the social,_cultural,_and genomic factors associated with health behaviors in adolescents of Mexican heritage. Several papers_examining_the role_of_such_factors in physical activity and_tobacco use were published during_the current"}
{"text": "-HF coupling but not PFC activation. DLPFC, which communicates with HF, inferior parietal lobules and ventrolateral PFC during working memory (WM), is probably susceptible to genetic modulation and our data suggest that genes related to increased SZ susceptibility effect in this modulation. Imaging Genetics has allowed us", "synonym_substitution": "-HF coupling but not PFC activation. DLPFC, which communicates with HF, inferior parietal lobule and ventrolateral PFC during working memory (WM), is credibly susceptible to genic modulation and our datum suggest that gene related to increased SZ susceptibility impression in this intonation. Imaging Genetics has allowed us", "butter_fingers": "-HF foupling but not PFC actlvation. DLPFC, whnxh comkunicafes with HF, inferior parietal lobuled qnd vtutrolateral PFC durivg workinh memory (WM), ms probably suscxltible bj gehctic kidulation and pur data sgggest that geter xelated to increased SZ susceptibiliey effevt in this modulwtiom. Imafpnn Genetics has allowed us", "random_deletion": "-HF coupling but not PFC activation. DLPFC, with inferior parietal and ventrolateral PFC probably to genetic modulation our data suggest genes related to increased SZ susceptibility in this modulation. Imaging Genetics has allowed us", "change_char_case": "-HF coupling but not PFC activaTion. DLPFC, wHich cOmmUniCaTes wIth Hf, inferior parieTAl loBules and ventrolateral PfC durInG WorkINg MemorY (WM), is prOBaBLY suScEpTibLe TO gEnetiC moDulatioN and our datA suGgEst that genes RElAted to incrEasEd SZ susceptiBilIty effEcT in THis moDulAtion. imaginG genetiCs has alloWeD Us", "whitespace_perturbation": "-HF coupling but not PFC a ctivation.  DLPF C,whi ch  com muni cates with HF, infe rior parietal lobulesand v en t rola t er al PF C durin g  w o r kin gme mor y( WM ), is  pr obablysusceptibl e t ogenetic modu l at ion and ou r d ata suggesttha t gene srel a ted t o i ncrea sed SZ suscep tibilityef f ect in this mo d u la tion . Imaging Genetic s  h a s allowed us", "underscore_trick": "-HF coupling_but not_PFC activation. DLPFC, which_communicates with_HF,_inferior parietal_lobules_and ventrolateral PFC_during working memory_(WM), is probably susceptible_to genetic modulation_and_our data suggest that genes related to increased SZ susceptibility effect in this modulation._Imaging_Genetics has_allowed_us"}
{"text": "-LS1 and Xen-1. The reverse transcriptase domain of this ERV shows closest similarity to the ancient env-deficient ERV-L family of endogenous retroviruses, and to the exogenous spumaviruses confirming an evolutionary relationship between these subgroups. The TM domain of the XTERV-LS env clusters", "synonym_substitution": "-LS1 and Xen-1. The reverse transcriptase domain of this ERV shows closest similarity to the ancient env - insufficient ERV - L syndicate of endogenous retroviruses, and to the exogenous spumaviruses confirming an evolutionary kinship between these subgroups. The TM world of the XTERV - LS env clusters", "butter_fingers": "-LS1 wnd Xen-1. The reverse tranrcriptase domaiu of thms ERV ahows clusest similarity to the ancixnt wnv-dedicient ERV-L family of endogenols retrovurusts, and to the exojsnous sibmavidmses eoifirming an evokutionary selationship batdezn these subgroups. The TM domain of ehe XTETV-PS env clusterf", "random_deletion": "-LS1 and Xen-1. The reverse transcriptase domain ERV closest similarity the ancient env-deficient and the exogenous spumaviruses an evolutionary relationship these subgroups. The TM domain of XTERV-LS env clusters", "change_char_case": "-LS1 and Xen-1. The reverse transcrIptase domaIn of tHis eRV ShOws cLoseSt similarity to THe anCient env-deficient ERV-L fAmily Of ENdogENoUs retRovirusES, aND To tHe ExOgeNoUS sPumavIruSes confIrming an evOluTiOnary relatioNShIp between tHesE subgroups. ThE TM Domain Of The xtERV-Ls enV clusTers", "whitespace_perturbation": "-LS1 and Xen-1. The revers e transcri ptase  do mai nof t hisERV shows clos e st s imilarity to the ancie nt en v- d efic i en t ERV -L fami l yo f  en do ge nou sr et rovir use s, andto the exo gen ou s spumavirus e sconfirming  an  evolutionar y r elatio ns hip betwe enthese  subgr o ups. T he TM dom ai n  of th e  XTERV- L S  e nv c lusters", "underscore_trick": "-LS1 and_Xen-1. The_reverse transcriptase domain of_this ERV_shows_closest similarity_to_the ancient env-deficient_ERV-L family of_endogenous retroviruses, and to_the exogenous spumaviruses_confirming_an evolutionary relationship between these subgroups. The TM domain of the XTERV-LS env clusters"}
{"text": " expressed from a codon-optimized vector. Interestingly, while CBF increased cellular levels of Vif, virus-associated levels of Vif did not increase. CBF itself was excluded from virions suggesting that CBF-Vif complexes are sequestered within cells. CBF neither affected expression of viral Gag nor", "synonym_substitution": "expressed from a codon - optimized vector. Interestingly, while CBF increased cellular levels of Vif, virus - consociate degree of Vif did not increase. CBF itself was excluded from virions suggesting that CBF - Vif complex are sequestered within cells. CBF neither feign construction of viral Gag nor", "butter_fingers": " exoressed from a codon-optioized vector. Injeeestinjly, whime CBF ivcreased cellular levels of Tif, cirus-qssociated levels of Vkf did non increasw. CBH itself was excluded from virjlns vnggesting that GBF-Vif compnexes are sequasgexed within cells. CBF neither affecteq exprexslon of viral Gwg npw", "random_deletion": "expressed from a codon-optimized vector. Interestingly, while cellular of Vif, levels of Vif was from virions suggesting CBF-Vif complexes are within cells. CBF neither affected expression viral Gag nor", "change_char_case": " expressed from a codon-optimiZed vector. INtereStiNglY, wHile cBF iNcreased cellulAR levEls of Vif, virus-associateD leveLs OF Vif DId Not inCrease. Cbf iTSElf WaS eXclUdED fRom viRioNs suggeSting that CbF-VIf Complexes are SEqUestered wiThiN cells. CBF neiTheR affecTeD exPRessiOn oF viraL Gag noR", "whitespace_perturbation": " expressed from a codon-op timized ve ctor.  In ter es ting ly,while CBF incr e ased  cellular levels of Vi f, vi ru s -ass o ci atedlevelso fV i f d id  n otin c re ase.CBF  itself  was exclu ded  f rom virionss ug gesting th atCBF-Vif comp lex es are  s equ e stere d w ithin  cells .  CBF n either af fe c ted ex p ression o fvira l Gag nor", "underscore_trick": " expressed_from a_codon-optimized vector. Interestingly, while_CBF increased_cellular_levels of_Vif,_virus-associated levels of_Vif did not_increase. CBF itself was_excluded from virions_suggesting_that CBF-Vif complexes are sequestered within cells. CBF neither affected expression of viral Gag_nor"}
{"text": "-onset multifocal osteomyelitis, periosteitis and pustulosis and systemic inflammation. The disease mimics infectious osteomyelitis and sepsis and has a high mortality if untreated. In collaboration with Dr. Jesus from Brazil and Dr. El-Shanti from Qatar a novel 15 basepair deletion in 2", "synonym_substitution": "-onset multifocal osteomyelitis, periosteitis and pustulosis and systemic inflammation. The disease mimics infectious osteomyelitis and sepsis and has a high deathrate if untreated. In collaboration with Dr. Jesus from Brazil and Dr. El - Shanti from Qatar a fresh 15 basepair omission in 2", "butter_fingers": "-onsft multifocal osteomyeliuis, periosteitis cbd pusvulosis and sysgemic inflammation. The diseade mimixs infectious osteomyeuitis and sepsis qnd ias a high mortality if mutreafcd. In rollaboration wlth Dr. Jesuv from Brazil dna Br. El-Shanti from Qatar a novel 15 base[air dekehion in 2", "random_deletion": "-onset multifocal osteomyelitis, periosteitis and pustulosis and The mimics infectious and sepsis and untreated. collaboration with Dr. from Brazil and El-Shanti from Qatar a novel 15 deletion in 2", "change_char_case": "-onset multifocal osteomyeliTis, periostEitis And PusTuLosiS and Systemic inflamMAtioN. The disease mimics infecTious OsTEomyELiTis anD sepsis ANd HAS a hIgH mOrtAlITy If untReaTed. In coLlaboratioN wiTh dr. Jesus from BRAzIl and Dr. El-SHanTi from Qatar a NovEl 15 basePaIr dELetioN in 2", "whitespace_perturbation": "-onset multifocal osteomye litis, per ioste iti s a nd  pus tulo sis and system i c in flammation. The diseas e mim ic s  inf e ct iousosteomy e li t i s a nd  s eps is an d has  ahigh mo rtality if  un tr eated. In co l la boration w ith  Dr. Jesus f rom  Brazi land Dr. E l-S hanti  fromQ atar a  novel 15  b a sepair deletio n in  2", "underscore_trick": "-onset multifocal_osteomyelitis, periosteitis_and pustulosis and systemic_inflammation. The_disease_mimics infectious_osteomyelitis_and sepsis and_has a high_mortality if untreated. In_collaboration with Dr._Jesus_from Brazil and Dr. El-Shanti from Qatar a novel 15 basepair deletion in 2"}
{"text": " substituent of the purine forms a hydrogen bond interaction with the backbone carbonyl of Met171. The 4-hydroxy substituent of the cyclopentyl group forms a hydrogen bond with the backbone nitrogen of Phe88. The triphosphate group of CMCP-TP forms polar interactions with multiple amino acid residues of", "synonym_substitution": "substituent of the purine forms a hydrogen bond interaction with the backbone carbonyl of Met171. The 4 - hydroxy substituent of the cyclopentyl group forms a hydrogen bail with the spine nitrogen of Phe88. The triphosphate group of CMCP - TP forms polar interactions with multiple amino acid remainder of", "butter_fingers": " suhstituent of the purine norms a hydrogen bond iiteractjon with the backbone carbonyl of Mev171. Thw 4-hydeoxy substituent of thd cyclopejtyl groyp fiems a hydrogen bond with bhe bccjbone nitrogen of Phe88. Tha triphosphate gfobp of CMCP-TP forms polar interactionf with kuptiple amino asid gefiduss of", "random_deletion": "substituent of the purine forms a hydrogen with backbone carbonyl Met171. The 4-hydroxy forms hydrogen bond with backbone nitrogen of The triphosphate group of CMCP-TP forms interactions with multiple amino acid residues of", "change_char_case": " substituent of the purine forMs a hydrogeN bond IntEraCtIon wIth tHe backbone carbONyl oF Met171. The 4-hydroxy substituEnt of ThE CyclOPeNtyl gRoup forMS a HYDroGeN bOnd WiTH tHe bacKboNe nitroGen of Phe88. ThE trIpHosphate grouP Of cMCP-TP formS poLar interactiOns With muLtIplE Amino AciD resiDues of", "whitespace_perturbation": " substituent of the purine  forms a h ydrog enbon dinte ract ion with the b a ckbo ne carbonyl of Met171.  The4- h ydro x ysubst ituento ft h e c yc lo pen ty l  g roupfor ms a hy drogen bon d w it h the backbo n enitrogen o f P he88. The tr iph osphat egro u p ofCMC P-TPformsp olar i nteractio ns with m u ltiplea m in o ac id residues of", "underscore_trick": " substituent_of the_purine forms a hydrogen_bond interaction_with_the backbone_carbonyl_of Met171. The_4-hydroxy substituent of_the cyclopentyl group forms_a hydrogen bond_with_the backbone nitrogen of Phe88. The triphosphate group of CMCP-TP forms polar interactions with_multiple_amino acid_residues_of"}
{"text": " 2) inhibition of anterograde trafficking of newly synthesized HLA-I from the ER to the plasma membrane. We show here that Nef simultaneously uses both mechanisms to downregulate HLA- I in PBMCs or HeLa cells. Consistent with this, we found using Fluorescence Correlation Spectroscopy that a third of diff", "synonym_substitution": "2) inhibition of anterograde trafficking of newly synthesized HLA - I from the ER to the plasma membrane. We show here that Nef simultaneously uses both mechanism to downregulate HLA- I in PBMCs or HeLa cell. Consistent with this, we found using Fluorescence Correlation Spectroscopy that a third base of diff", "butter_fingers": " 2) ijhibition of anterograde trafficking of newly vyntheaized HLX-I from the ER to the plasma mwmbrabe. We show here that Ndf simultwneously usew both mechehisms to downdcgulace HLA- I in PBMCx or HeLa wells. Consistett wnth this, we found using Fluorescence Correlstlon Spectroscoky thse a fhird of diff", "random_deletion": "2) inhibition of anterograde trafficking of newly from ER to plasma membrane. We uses mechanisms to downregulate I in PBMCs HeLa cells. Consistent with this, we using Fluorescence Correlation Spectroscopy that a third of diff", "change_char_case": " 2) inhibition of anterograde trAfficking oF newlY syNthEsIzed hLA-I From the ER to the PLasmA membrane. We show here thaT Nef sImULtanEOuSly usEs both mEChANIsmS tO dOwnReGUlAte HLa- I iN PBMCs oR HeLa cells. conSiStent with thiS, We Found using fluOrescence CorRelAtion SPeCtrOScopy ThaT a thiRd of diFF", "whitespace_perturbation": " 2) inhibition of anterogr ade traffi cking  of  ne wl y sy nthe sized HLA-I fr o m th e ER to the plasma mem brane .W e sh o wherethat Ne f  s i m ult an eo usl yu se s bot h m echanis ms to down reg ul ate HLA- I i n  P BMCs or He Lacells. Consi ste nt wit hthi s , wefou nd us ing Fl u oresce nce Corre la t ion Sp e ctrosco p y  t hata third of diff", "underscore_trick": " 2)_inhibition of_anterograde trafficking of newly_synthesized HLA-I_from_the ER_to_the plasma membrane._We show here_that Nef simultaneously uses_both mechanisms to_downregulate_HLA- I in PBMCs or HeLa cells. Consistent with this, we found using Fluorescence_Correlation_Spectroscopy that_a_third_of diff"}
{"text": " is affected by polymorphisms in genes controlling metformin metabolism (21). We also participated in a multi-site randomized-controlled trial of beloranib, a methionyl aminopeptidase 2 inhibitor, to treat the hyperphagia of patients with the Prader Willi Syndrome (19). We have recently initiated additional", "synonym_substitution": "is affected by polymorphisms in genes controlling metformin metamorphosis (21). We besides enter in a multi - site randomize - controlled test of beloranib, a methionyl aminopeptidase 2 inhibitor, to treat the hyperphagia of patients with the Prader Willi Syndrome (19). We have recently lead up additional", "butter_fingers": " is affected by polymorphisos in genes conjrilling metfodmin metxbolism (21). We also participatev in a muoti-site randomized-contfolled trpal of beooraiib, a methionyl ejinopepbndase 2 inhnbmtor, to treat tme hyperphacia of patientv dich the Prader Willi Syndrome (19). We havq recenylj initiated adqitipgal", "random_deletion": "is affected by polymorphisms in genes controlling (21). also participated a multi-site randomized-controlled aminopeptidase inhibitor, to treat hyperphagia of patients the Prader Willi Syndrome (19). We recently initiated additional", "change_char_case": " is affected by polymorphisms In genes conTrollIng MetFoRmin MetaBolism (21). We also paRTiciPated in a multi-site randoMized-CoNTrolLEd Trial Of belorANiB, A MetHiOnYl aMiNOpEptidAse 2 InhibitOr, to treat tHe hYpErphagia of paTIeNts with the praDer Willi SyndRomE (19). We havE rEceNTly inItiAted aDditioNAl", "whitespace_perturbation": " is affected by polymorphi sms in gen es co ntr oll in g me tfor min metabolism (21) . We also participated  in a  m u lti- s it e ran domized - co n t rol le dtri al of  belo ran ib, a m ethionyl a min op eptidase 2 i n hi bitor, totre at the hyper pha gia of  p ati e nts w ith  thePrader WilliSyndrome(1 9 ). Weh ave rec e n tl y in itiated additiona l ", "underscore_trick": " is_affected by_polymorphisms in genes controlling_metformin metabolism_(21)._We also_participated_in a multi-site_randomized-controlled trial of_beloranib, a methionyl aminopeptidase_2 inhibitor, to_treat_the hyperphagia of patients with the Prader Willi Syndrome (19). We have recently initiated_additional"}
{"text": "1 Pre-clinical studies to evaluate the efficacy of FV in human LAD-1 CD34+ cells. We have conducted extensive pre-clinical studies to investigate the efficacy of clinical grade FV expressing the human CD18 cDNA (FV-hCD18) in HSPCs collected from subjects with a molecularly confirmed", "synonym_substitution": "1 Pre - clinical studies to evaluate the efficacy of FV in human LAD-1 CD34 + cells. We have behave across-the-board pre - clinical studies to investigate the efficacy of clinical grade FV carry the homo CD18 cDNA (FV - hCD18) in HSPCs collected from subjects with a molecularly confirm", "butter_fingers": "1 Prf-clinical studies to evauuate the efficcxy of HV in hhman LAD-1 CD34+ cells. We have conducted xxtebsive pre-clinical studies tu investihate the effmcacy of clinical grade NR expdcssiny vhe human CD18 cDKA (FV-hCD18) in HSPCs collectad fxom subjects with a molecularly confyrmed", "random_deletion": "1 Pre-clinical studies to evaluate the efficacy in LAD-1 CD34+ We have conducted the of clinical grade expressing the human cDNA (FV-hCD18) in HSPCs collected from with a molecularly confirmed", "change_char_case": "1 Pre-clinical studies to evaluAte the effiCacy oF FV In hUmAn LAd-1 CD34+ cElls. We have condUCted Extensive pre-clinical stUdies To INvesTIgAte thE efficaCY oF CLinIcAl GraDe fv eXpresSinG the humAn CD18 cDNA (FV-HCD18) In hSPCs collectED fRom subjectS wiTh a molecularLy cOnfirmEd", "whitespace_perturbation": "1 Pre-clinical studies toevaluate t he ef fic acy  o f FV  inhuman LAD-1 CD 3 4+ c ells. We have conducte d ext en s ivep re -clin ical st u di e s  to  i nv est ig a te  theeff icacy o f clinical  gr ad e FV express i ng  the human  CD 18 cDNA (FV- hCD 18) in  H SPC s  coll ect ed fr om sub j ects w ith a mol ec u larlyc onfirme d ", "underscore_trick": "1 Pre-clinical_studies to_evaluate the efficacy of_FV in_human_LAD-1 CD34+_cells._We have conducted_extensive pre-clinical studies_to investigate the efficacy_of clinical grade_FV_expressing the human CD18 cDNA (FV-hCD18) in HSPCs collected from subjects with a molecularly_confirmed"}
{"text": "omatic mosaicism in NLRP3 accounts for a large number of mutations in mutation negative patients assessed by conventional methods. 4. Long-term treatment effect of IL-1 blockade in patients with NOMID indicates that treatment of this devastating illness is safe and effective at least up to 5 years, improves disability and retards", "synonym_substitution": "omatic mosaicism in NLRP3 accounts for a large number of mutations in mutant damaging patients assessed by ceremonious methods. 4. farseeing - term treatment consequence of IL-1 blockade in patients with NOMID indicates that discussion of this crushing illness is safe and effective at least up to 5 year, improves disability and retards", "butter_fingers": "omahic mosaicism in NLRP3 acgounts for a laryw numbxr of mhtations in mutation negative patienvs awsesstb by conventional meghods. 4. Lojg-term teeatnwnt effect of IL-1 blockads in 'avients with NOMLD indicatev that treatmett oy this devastating illness is safe agd effevtlve at least uk to 5 reara, improves disability and retards", "random_deletion": "omatic mosaicism in NLRP3 accounts for a of in mutation patients assessed by effect IL-1 blockade in with NOMID indicates treatment of this devastating illness is and effective at least up to 5 years, improves disability and retards", "change_char_case": "omatic mosaicism in NLRP3 accoUnts for a laRge nuMbeR of MuTatiOns iN mutation negatIVe paTients assessed by convenTionaL mEThodS. 4. loNg-terM treatmENt EFFecT oF Il-1 blOcKAdE in paTieNts with nOMID indicAteS tHat treatment OF tHis devastaTinG illness is saFe aNd effeCtIve AT leasT up To 5 yeaRs, imprOVes disAbility anD rETards", "whitespace_perturbation": "omatic mosaicism in NLRP3accounts f or alar genu mber  ofmutations in m u tati on negative patients a ssess ed by c o nv entio nal met h od s .  4.  L on g-t er m  t reatm ent  effect  of IL-1 b loc ka de in patien t swith NOMID  in dicates that  tr eatmen toft his d eva stati ng ill n ess is  safe and  e f fectiv e  at lea s t  u p to  5 years, improve s  d i sability and r etards ", "underscore_trick": "omatic mosaicism_in NLRP3_accounts for a large_number of_mutations_in mutation_negative_patients assessed by_conventional methods. 4._Long-term treatment effect of_IL-1 blockade in_patients_with NOMID indicates that treatment of this devastating illness is safe and effective at_least_up to_5_years,_improves disability and retards"}
{"text": "minopeptidase Regulator of TNFR1 Shedding) as a type II integral membrane protein that associates with the TNFR1 extracellular domain. An association between membrane-associated ARTS-1 and TNFR1 was confirmed by co-immunoprecipitation experiments utilizing human pulmonary epithelial and umbilical vein endothelial cells.", "synonym_substitution": "minopeptidase Regulator of TNFR1 Shedding) as a type II integral membrane protein that associates with the TNFR1 extracellular domain. An affiliation between membrane - consociate ARTS-1 and TNFR1 was confirmed by co - immunoprecipitation experiment utilize human pulmonary epithelial and umbilical vein endothelial cells.", "butter_fingers": "minlpeptidase Regulator of UNFR1 Shedding) as c type MI intefral memcrane protein that associated qith uke TNFR1 extracellulaf domain. Wn assocuatiib between membrane-associzbed AXTW-1 and TNFR1 was confirmed by co-immunoprackpntation experiments utilizing human [ulmonaty epithelial anq umnyliczl vein endothelial cells.", "random_deletion": "minopeptidase Regulator of TNFR1 Shedding) as a integral protein that with the TNFR1 membrane-associated and TNFR1 was by co-immunoprecipitation experiments human pulmonary epithelial and umbilical vein cells.", "change_char_case": "minopeptidase Regulator of TnFR1 SheddinG) as a tYpe iI iNtEgraL memBrane protein thAT assOciates with the TNFR1 extrAcellUlAR domAIn. an assOciatioN BeTWEen MeMbRanE-aSSoCiateD ARtS-1 and TNfR1 was confiRmeD bY co-immunopreCIpItation expEriMents utiliziNg hUman puLmOnaRY epitHelIal anD umbilICal veiN endothelIaL Cells.", "whitespace_perturbation": "minopeptidase Regulator of  TNFR1 She dding ) a s a  t ypeII i ntegral membra n e pr otein that associateswithth e  TNF R 1extra cellula r  d o m ain .An  as so c ia tionbet ween me mbrane-ass oci at ed ARTS-1 an d  T NFR1 was c onf irmed by co- imm unopre ci pit a tionexp erime nts ut i lizing  human pu lm o nary e p ithelia l an d um bilical vein endo t he l ial cells.", "underscore_trick": "minopeptidase Regulator_of TNFR1_Shedding) as a type_II integral_membrane_protein that_associates_with the TNFR1_extracellular domain. An_association between membrane-associated ARTS-1_and TNFR1 was_confirmed_by co-immunoprecipitation experiments utilizing human pulmonary epithelial and umbilical vein endothelial cells."}
{"text": "1 is an enzyme that is known to function in the repair of damaged DNA. In collaboration with the lab of Dr. Yves Pommier at NCI, using a mutant line in which TDP1 levels are severely reduced, Dongyu Guo is studying the role of TDP1 in the Drosophila nervous", "synonym_substitution": "1 is an enzyme that is known to function in the repair of damaged deoxyribonucleic acid. In collaboration with the lab of Dr. Yves Pommier at NCI, use a mutant line in which TDP1 levels are hard reduce, Dongyu Guo is studying the role of TDP1 in the Drosophila anxious", "butter_fingers": "1 is an enzyme that is known to function in the re'air of damaged DNA. In collaboration with tie lqb of Dr. Yves Pommier at NCK, using a mutant oine un which TVL1 levels are acverenb reduced, Dongyo Guo is stugying the role ow CDP1 in the Drosophila nervous", "random_deletion": "1 is an enzyme that is known in repair of DNA. In collaboration Yves at NCI, using mutant line in TDP1 levels are severely reduced, Dongyu is studying the role of TDP1 in the Drosophila nervous", "change_char_case": "1 is an enzyme that is known to fuNction in thE repaIr oF daMaGed DnA. In Collaboration wITh thE lab of Dr. Yves Pommier at NcI, usiNg A MutaNT lIne in Which TDp1 LeVELs aRe SeVerElY ReDuced, donGyu Guo iS studying tHe rOlE of TDP1 in the DROsOphila nervOus", "whitespace_perturbation": "1 is an enzyme that is kno wn to func tioninthe  r epai r of  damaged DNA.I n co llaboration with the l ab of  D r . Yv e sPommi er at N C I, u sin gamut an t  l ine i n w hich TD P1 levelsare  s everely redu c ed , Dongyu G uois studyingthe  roleof  TD P 1 inthe  Dros ophila nervou s", "underscore_trick": "1 is_an enzyme_that is known to_function in_the_repair of_damaged_DNA. In collaboration_with the lab_of Dr. Yves Pommier_at NCI, using_a_mutant line in which TDP1 levels are severely reduced, Dongyu Guo is studying the_role_of TDP1_in_the_Drosophila nervous"}
{"text": " microscopy studies we discovered an unexpected rapid recruitment of several important endocytic proteins and lipids to sites of exocytosis. These molecules include the regulatory lipid PIP2, and the proteins dynamin, amphiphysin, syndapin, and endophilin. We further discovered that mutations to several of these proteins altered the kinetics", "synonym_substitution": "microscopy studies we discovered an unexpected rapid recruitment of several important endocytic protein and lipid to site of exocytosis. These molecules include the regulative lipid PIP2, and the proteins dynamin, amphiphysin, syndapin, and endophilin. We further discovered that mutant to several of these proteins change the kinetics", "butter_fingers": " mifroscopy studies we discuvered an unexpgcred ra'id recduitment of several important endocyvic proteuns and lipids to siter of exocjtosis. Thwse nilecules iidlude tmz reghpatoxy lipid PIP2, and the protehns dynamin, am[hkpkysin, syndapin, and endophilin. We fureher dixclvered that mujatiomf to several of these proteins altered the kiietics", "random_deletion": "microscopy studies we discovered an unexpected rapid several endocytic proteins lipids to sites the lipid PIP2, and proteins dynamin, amphiphysin, and endophilin. We further discovered that to several of these proteins altered the kinetics", "change_char_case": " microscopy studies we discovEred an unexPecteD raPid ReCruiTmenT of several impoRTant Endocytic proteins and liPids tO sITes oF ExOcytoSis. ThesE MoLECulEs InCluDe THe RegulAtoRy lipid pIP2, and the pRotEiNs dynamin, ampHIpHysin, syndaPin, And endophiliN. We FurtheR dIscOVered ThaT mutaTions tO SeveraL of these pRoTEins alTEred the KINeTics", "whitespace_perturbation": " microscopy studies we dis covered an  unex pec ted  r apid  rec ruitment of se v eral  important endocytic p rotei ns andl ip ids t o sites of e xoc yt os is.  T h es e mol ecu les inc lude the r egu la tory lipid P I P2 , and thepro teins dynami n,amphip hy sin ,  synd api n, an d endo p hilin.  We furth er discov e red tha t mu tati ons to several of th e se proteins al teredth e  k i n eti cs", "underscore_trick": " microscopy_studies we_discovered an unexpected rapid_recruitment of_several_important endocytic_proteins_and lipids to_sites of exocytosis._These molecules include the_regulatory lipid PIP2,_and_the proteins dynamin, amphiphysin, syndapin, and endophilin. We further discovered that mutations to several_of_these proteins_altered_the_kinetics"}
{"text": " antibodies from an immunization-challenge study in Aotus monkeys for functional activity. We are continuing to collaborate with Dr. James Burns (Drexel University) on his novel fusion protein of P. falciparum MSP1 and MSP8. We have shown that it elicits extremely high levels of antibodies with GIA", "synonym_substitution": "antibodies from an immunization - challenge study in Aotus monkeys for functional activity. We are continue to collaborate with Dr. James Burns (Drexel University) on his fresh fusion protein of P. falciparum MSP1 and MSP8. We have shown that it elicit highly high levels of antibodies with GIA", "butter_fingers": " anhibodies from an immunizxtion-challenge study ii Aotus monkeys for functional activity. We ere xontibuing to collaborate wkth Dr. Jales Burnw (Drtxel University) oi his noyzl fualon pxovein of P. falcikarum MSP1 ang MSP8. We have vhuwu that it elicits extremely high levqls of snhibodies with DIA", "random_deletion": "antibodies from an immunization-challenge study in Aotus functional We are to collaborate with on novel fusion protein P. falciparum MSP1 MSP8. We have shown that it extremely high levels of antibodies with GIA", "change_char_case": " antibodies from an immunizatIon-challenGe stuDy iN AoTuS monKeys For functional aCTiviTy. We are continuing to colLaborAtE With dR. JAmes BUrns (DreXEl uNIveRsItY) on HiS NoVel fuSioN proteiN of P. falcipAruM MsP1 and MSP8. We haVE sHown that it EliCits extremelY hiGh leveLs Of aNTibodIes With GiA", "whitespace_perturbation": " antibodies from an immuni zation-cha lleng e s tud yin A otus  monkeys for f u ncti onal activity. We areconti nu i ng t o  c ollab orate w i th D r.Ja me s B ur n s(Drex elUnivers ity) on hi s n ov el fusion pr o te in of P. f alc iparum MSP1and  MSP8.  W e h a ve sh own  that  it el i cits e xtremelyhi g h leve l s of an t i bo dies  with GIA", "underscore_trick": " antibodies_from an_immunization-challenge study in Aotus_monkeys for_functional_activity. We_are_continuing to collaborate_with Dr. James_Burns (Drexel University) on_his novel fusion_protein_of P. falciparum MSP1 and MSP8. We have shown that it elicits extremely high_levels_of antibodies_with_GIA"}
{"text": " mortality. Direct killing of infected CD4+ T cells and evasion of immune responses underlie the pathogenesis of AIDS. The membrane-associated viral Nef protein, which is critical for viral replication and virulence downregulates many immune cell receptors including CD4 and MHC class I. In the previous reporting period(s),", "synonym_substitution": "mortality. Direct killing of infected CD4 + T cells and evasion of immune answer underlie the pathogenesis of AIDS. The membrane - consociate viral Nef protein, which is critical for viral replication and virulence downregulates many immune cell receptors include CD4 and MHC class I. In the previous coverage period(s),", "butter_fingers": " mogtality. Direct killing on infected CD4+ T ewlls aid evasjon of iomune responses underlie the pqthogtuesis of AIDS. The meobrane-asslciated cirao Nef protemh, which is crjbical hor viral repligation and eirulence downseeupates many immune cell receptors insluding CF4 and MHC clasf I. Pn the irtvious reporting period(s),", "random_deletion": "mortality. Direct killing of infected CD4+ T evasion immune responses the pathogenesis of protein, is critical for replication and virulence many immune cell receptors including CD4 MHC class I. In the previous reporting period(s),", "change_char_case": " mortality. Direct killing of iNfected CD4+ T Cells And EvaSiOn of ImmuNe responses undERlie The pathogenesis of AIDS. THe memBrANe-asSOcIated Viral NeF PrOTEin, WhIcH is CrITiCal foR viRal replIcation and VirUlEnce downreguLAtEs many immuNe cEll receptors IncLuding cD4 And mhC claSs I. in the PrevioUS reporTing perioD(s),", "whitespace_perturbation": " mortality. Direct killing  of infect ed CD 4+T c el ls a nd e vasion of immu n e re sponses underlie the p athog en e siso fAIDS.  The me m br a n e-a ss oc iat ed vi ral N efprotein , which is  cr it ical for vir a lreplicatio n a nd virulence  do wnregu la tes manyimm une c ell re c eptors  includin gC D4 and MHC cla s s  I . In  the previous rep o rt i ng period(s),", "underscore_trick": " mortality._Direct killing_of infected CD4+ T_cells and_evasion_of immune_responses_underlie the pathogenesis_of AIDS. The_membrane-associated viral Nef protein,_which is critical_for_viral replication and virulence downregulates many immune cell receptors including CD4 and MHC class_I._In the_previous_reporting_period(s),"}
{"text": " 1% of epithelial cells in the gastrointestinal tract, represent the largest population of hormone-producing cells in the body. The enteroendocrine cells share a common lineage with other non-endocrine cell lineages and originate from primitive intestinal stem cells in the intestinal crypts. There are two complementary populations of stem cells, a", "synonym_substitution": "1% of epithelial cells in the gastrointestinal tract, represent the largest population of hormone - produce cell in the body. The enteroendocrine cells share a coarse lineage with other non - endocrine cellular telephone lineages and originate from primitive intestinal stem cell in the intestinal crypts. There are two complemental populations of stem cells, a", "butter_fingers": " 1% ov epithelial cells in tht gastrointestinal tract, repreaent the largest population of hormoie-priducibg cells in the body. Tfe enterovndocrine celow share a rkmmon llueage aith ither non-endoctine cell liteages and oricivace from primitive intestinal stem cejls in yhf intestinal ctypts. Ehers are two complementary populationa of sttm cells, a", "random_deletion": "1% of epithelial cells in the gastrointestinal the population of cells in the a lineage with other cell lineages and from primitive intestinal stem cells in intestinal crypts. There are two complementary populations of stem cells, a", "change_char_case": " 1% of epithelial cells in the gasTrointestiNal trAct, RepReSent The lArgest populatiON of hOrmone-producing cells in The boDy. tHe enTErOendoCrine ceLLs SHAre A cOmMon LiNEaGe witH otHer non-eNdocrine ceLl lInEages and origINaTe from primItiVe intestinal SteM cells In The INtestInaL crypTs. TherE Are two ComplemenTaRY populATions of STEm CellS, a", "whitespace_perturbation": " 1% of epithelial cells in  the gastr ointe sti nal  t ract , re present the la r gest  population of hormone -prod uc i ng c e ll s inthe bod y .T h e e nt er oen do c ri ne ce lls  sharea common l ine ag e with other no n-endocrin e c ell lineages  an d orig in ate frompri mitiv e inte s tinalstem cell si n thei ntestin a l  c rypt s. There are twoc om p lementary popu lation so fs t emcel ls, a", "underscore_trick": " 1%_of epithelial_cells in the gastrointestinal_tract, represent_the_largest population_of_hormone-producing cells in_the body. The_enteroendocrine cells share a_common lineage with_other_non-endocrine cell lineages and originate from primitive intestinal stem cells in the intestinal crypts._There_are two_complementary_populations_of stem cells, a"}
{"text": ") vs continuous sitting. We have recently found similar decreases in insulin and c-peptide response to glucose challenges in children with overweight and obesity. Interrupting sedentary time with brief moderate-intensity walking thus improved short-term metabolic function. A new trial beginning in 2017 will test if these acute improvements are sustained over 1 week.", "synonym_substitution": ") vs continuous sitting. We have recently found similar decreases in insulin and vitamin c - peptide reception to glucose challenges in children with overweight and fleshiness. Interrupting sedentary time with brief moderate - volume walking thus better short - term metabolic routine. A new trial begin in 2017 will test if these acute improvements are sustained over 1 week.", "butter_fingers": ") vs continuous sitting. We hxve recently foone siminar dedreases kn insulin and c-peptide resplnwe to glucose challenges in children with ovwrwemght and obesity. Interruicing acdentcrb time with brigf moderate-ittensity walkitg tkus improved short-term metabolic funstion. A nfw trial beginging yn 2017 splo test if these acute improvejents age sustained over 1 week.", "random_deletion": ") vs continuous sitting. We have recently decreases insulin and response to glucose and Interrupting sedentary time brief moderate-intensity walking improved short-term metabolic function. A new beginning in 2017 will test if these acute improvements are sustained over 1", "change_char_case": ") vs continuous sitting. We have Recently foUnd siMilAr dEcReasEs in Insulin and c-pepTIde rEsponse to glucose challeNges iN cHIldrEN wIth ovErweighT AnD OBesItY. INteRrUPtIng seDenTary timE with brief ModErAte-intensity WAlKing thus imProVed short-term MetAbolic FuNctIOn. A neW trIal beGinninG In 2017 will Test if theSe ACute imPRovemenTS ArE susTained over 1 week.", "whitespace_perturbation": ") vs continuous sitting. W e have rec ently  fo und  s imil ar d ecreases in in s ulin  and c-peptide respons e togl u cose ch allen ges inc hi l d ren  w it h o ve r we ightand  obesit y. Interru pti ng  sedentary t i me  with brie f m oderate-inte nsi ty wal ki ngt hus i mpr ovedshort- t erm me tabolic f un c tion.A  new tr i a lbegi nning in 2017 wil l  t e st if these ac ute im pr o ve m e nts  ar e sustaine dover1  week.", "underscore_trick": ") vs_continuous sitting._We have recently found_similar decreases_in_insulin and_c-peptide_response to glucose_challenges in children_with overweight and obesity._Interrupting sedentary time_with_brief moderate-intensity walking thus improved short-term metabolic function. A new trial beginning in 2017_will_test if_these_acute_improvements are sustained over 1_week."}
{"text": " have a detectable mutation. In addition, there is significant clinical heterogeneity among affected individuals, including members of the same family harboring the same mutations, which is often explained by oligo-digenic inheritance patterns. Exome sequencing (ES) has been performed in the Molecular Genomics Core (NICHD) on many", "synonym_substitution": "have a detectable mutation. In addition, there is meaning clinical heterogeneity among involve individuals, including extremity of the like family harboring the same mutant, which is often explained by oligo - digenic inheritance form. Exome sequencing (ES) has been performed in the Molecular Genomics Core (NICHD) on many", "butter_fingers": " hage a detectable mutation. In addition, thgrw is smgnificznt clinkcal heterogeneity among affxctee induviduals, including memcers of tje same damiot harborinj the same mutzbions, xhich is often gxplained by oligo-digenic hnfexitance patterns. Exome sequencing (ES) has bern performed in jhe Mpjecumar Genomics Core (NICHD) on many", "random_deletion": "have a detectable mutation. In addition, there clinical among affected including members of same which is often by oligo-digenic inheritance Exome sequencing (ES) has been performed the Molecular Genomics Core (NICHD) on many", "change_char_case": " have a detectable mutation. In Addition, thEre is SigNifIcAnt cLiniCal heterogeneiTY amoNg affected individuals, iNcludInG MembERs Of the Same famILy HARboRiNg The SaME mUtatiOns, Which is Often explaIneD bY oligo-digeniC InHeritance pAttErns. Exome seqUenCing (ES) HaS beEN perfOrmEd in tHe MoleCUlar GeNomics CorE (NicHD) on mANy", "whitespace_perturbation": " have a detectable mutatio n. In addi tion,  th ere  i s si gnif icant clinical hete rogeneity among affect ed in di v idua l s,  incl uding m e mb e r s o fth e s am e  f amily  ha rboring  the samemut at ions, whichi soften expl ain ed by oligo- dig enic i nh eri t ancepat terns . Exom e  seque ncing (ES )h as bee n  perfor m e din t he Molecular Geno m ic s  Core (NICHD)on man y", "underscore_trick": " have_a detectable_mutation. In addition, there_is significant_clinical_heterogeneity among_affected_individuals, including members_of the same_family harboring the same_mutations, which is_often_explained by oligo-digenic inheritance patterns. Exome sequencing (ES) has been performed in the Molecular_Genomics_Core (NICHD)_on_many"}
{"text": " continue to explore the effect of aging on brain structures and systems, and the role of genetics on these changes. Finally, we explored changes in GABA levels in SZ in vivo and examined the genetic association with the ErbB4 gene. We found significant effects in A carriers as increased ErbB4 expression and higher", "synonym_substitution": "continue to explore the effect of aging on mind structure and systems, and the role of genetics on these changes. last, we explored changes in GABA level in SZ in vivo and examine the genetic affiliation with the ErbB4 gene. We line up meaning effects in A carriers as increase ErbB4 formula and higher", "butter_fingers": " cojtinue to explore the efnect of aging on brain vtructhres and systems, and the role of genxticw on ukese changes. Finally, we exploged changws ii GABA levels in SZ in vlro ans exakmned the genetig associatimn with the ErtB4 gzne. We found significant effects in W carrirrd as increased ErbN4 expdvswion and higher", "random_deletion": "continue to explore the effect of aging structures systems, and role of genetics explored in GABA levels SZ in vivo examined the genetic association with the gene. We found significant effects in A carriers as increased ErbB4 expression and", "change_char_case": " continue to explore the effecT of aging on Brain StrUctUrEs anD sysTems, and the role OF genEtics on these changes. FinAlly, wE eXPlorED cHangeS in GABA LEvELS in sZ In VivO aND eXaminEd tHe genetIc associatIon WiTh the ErbB4 genE. we Found signiFicAnt effects in a caRriers As IncREased erbb4 exprEssion ANd highEr", "whitespace_perturbation": " continue to explore the e ffect of a gingonbra in  str uctu res and system s , an d the role of genetics  on t he s e ch a ng es. F inally, we e xpl or ed  ch an g es  in G ABA  levels  in SZ inviv oand examined th e geneticass ociation wit h t he Erb B4  ge n e. We  fo und s ignifi c ant ef fects inAc arrier s  as inc r e as ed E rbB4 expression a n dh igher", "underscore_trick": " continue_to explore_the effect of aging_on brain_structures_and systems,_and_the role of_genetics on these_changes. Finally, we explored_changes in GABA_levels_in SZ in vivo and examined the genetic association with the ErbB4 gene. We_found_significant effects_in_A_carriers as increased ErbB4 expression_and higher"}
{"text": " mass, increased energy intake and feeding efficiency, but reduced fat-free mass compared with MC3R(hWT/hWT). MC3R(hDM/hDM) mice did not have increased adipose tissue inflammatory cell infiltration or greater expression of inflammatory markers despite their greater fat mass. Serum adiponectin was increased", "synonym_substitution": "mass, increased energy intake and feeding efficiency, but dilute fatty - free mass compare with MC3R(hWT / hWT). MC3R(hDM / hDM) shiner did not have increased adipose tissue inflammatory cellular telephone infiltration or greater expression of incendiary marker despite their greater fatty mass. Serum adiponectin was increased", "butter_fingers": " mads, increased energy intaye and feeding gfdicienry, but deduced wat-free mass compared with MR3R(hWR/hWT). NC3R(hDM/hDM) mice did not have incgeased adupost tissue inflammavkry cell infimbratimi or greater exkression of hnflammatory mdryexs despite their greater fat mass. Sewum adilojectin was incteasec", "random_deletion": "mass, increased energy intake and feeding efficiency, fat-free compared with MC3R(hDM/hDM) mice did inflammatory infiltration or greater of inflammatory markers their greater fat mass. Serum adiponectin increased", "change_char_case": " mass, increased energy intake And feeding EfficIenCy, bUt ReduCed fAt-free mass compARed wIth MC3R(hWT/hWT). MC3R(hDM/hDM) mIce diD nOT havE InCreasEd adipoSE tISSue InFlAmmAtORy Cell iNfiLtratioN or greater ExpReSsion of inflaMMaTory markerS deSpite their grEatEr fat mAsS. SeRUm adiPonEctin Was incREased", "whitespace_perturbation": " mass, increased energy in take and f eedin g e ffi ci ency , bu t reduced fat- f reemass compared with MC3 R(hWT /h W T).M C3 R(hDM /hDM) m i ce d idno thav ei nc rease d a diposetissue inf lam ma tory cell in f il tration or  gr eater expres sio n of i nf lam m atory  ma rkers  despi t e thei r greater  f a t mass .  Seruma d ip onec tin was increased ", "underscore_trick": " mass,_increased energy_intake and feeding efficiency,_but reduced_fat-free_mass compared_with_MC3R(hWT/hWT). MC3R(hDM/hDM) mice_did not have_increased adipose tissue inflammatory_cell infiltration or_greater_expression of inflammatory markers despite their greater fat mass. Serum adiponectin was increased"}
{"text": " immune evasion and promote viral persistence in part by downregulating major histocompatibility complex class I protein (MHC-I or HLA-I) from the cell surface. Two different models have been proposed to explain this phenomenon: 1) stimulation of MHC-I retrograde trafficking from and aberrant recycling to plasma membrane versus", "synonym_substitution": "immune evasion and promote viral persistence in part by downregulating major histocompatibility complex class I protein (MHC - I or HLA - iodine) from the cellular telephone surface. Two different model have been project to explain this phenomenon: 1) stimulation of MHC - I regress trafficking from and aberrant recycling to plasma membrane versus", "butter_fingers": " imlune evasion and promote viral persisteuxe in 'art by downregjlating major histocompatibipiry conplex class I protein (OHC-I or HPA-I) from the xell surfars. Two dlyferehb modzlw have been prpposed to axplain this pvevolenon: 1) stimulation of MHC-I retrograqe trafgifking from and abegrwnt dvcncling to plasma membrane versus", "random_deletion": "immune evasion and promote viral persistence in downregulating histocompatibility complex I protein (MHC-I surface. different models have proposed to explain phenomenon: 1) stimulation of MHC-I retrograde from and aberrant recycling to plasma membrane versus", "change_char_case": " immune evasion and promote viRal persistEnce iN paRt bY dOwnrEgulAting major histOCompAtibility complex class I ProteIn (mhC-I oR hLa-I) froM the celL SuRFAce. twO dIffErENt ModelS haVe been pRoposed to eXplAiN this phenomeNOn: 1) StimulatioN of mHC-I retrograDe tRafficKiNg fROm and AbeRrant RecyclINg to plAsma membrAnE Versus", "whitespace_perturbation": " immune evasion and promot e viral pe rsist enc e i npart  bydownregulating majo r histocompatibility c omple xc lass Iprote in (MHC - Io r  HL A- I)  fr om th e cel l s urface.  Two diffe ren tmodels haveb ee n proposed  to  explain thi s p henome no n:1 ) sti mul ation  of MH C -I ret rograde t ra f fickin g  from a n d  a berr ant recycling top la s ma membrane ve rsus", "underscore_trick": " immune_evasion and_promote viral persistence in_part by_downregulating_major histocompatibility_complex_class I protein_(MHC-I or HLA-I)_from the cell surface._Two different models_have_been proposed to explain this phenomenon: 1) stimulation of MHC-I retrograde trafficking from and_aberrant_recycling to_plasma_membrane_versus"}
{"text": ", biochemistry, and electrophysiology. However, the spatial organization, heterogeneity, and dynamics of these proteins have yet to be determined. Finding this organization is key to understanding how proteins regulate these systems in healthy cells and might malfunction in disease. Thus, we aim to map key proteins proposed to act during exocytosis in endocrine", "synonym_substitution": ", biochemistry, and electrophysiology. However, the spatial organization, heterogeneity, and dynamics of these proteins have so far to be determine. Finding this organization is key to understand how proteins regulate these arrangement in healthy cells and might malfunction in disease. therefore, we target to map key protein proposed to act during exocytosis in endocrine", "butter_fingers": ", bilchemistry, and electrophnsiology. However, the spetial odganizatkon, heterogeneity, and dynamirs od thewe proteins have yet tu be detegmined. Fibdinj this organizatmkn is kcv to hkderscaiding how protelns regulata these systemv kn healthy cells and might malfunctiog in dixewse. Thus, we aii to iap ivy proteins proposed to act durjng exobytosis in endocrone", "random_deletion": ", biochemistry, and electrophysiology. However, the spatial and of these have yet to is to understanding how regulate these systems healthy cells and might malfunction in Thus, we aim to map key proteins proposed to act during exocytosis in", "change_char_case": ", biochemistry, and electrophySiology. HowEver, tHe sPatIaL orgAnizAtion, heterogenEIty, aNd dynamics of these proteIns haVe YEt to BE dEtermIned. FinDInG THis OrGaNizAtIOn Is key To uNderstaNding how prOteInS regulate theSE sYstems in heAltHy cells and miGht MalfunCtIon IN diseAse. thus, wE aim to MAp key pRoteins prOpOSed to aCT during EXOcYtosIs in endocrine", "whitespace_perturbation": ", biochemistry, and electr ophysiolog y. Ho wev er,  t he s pati al organizatio n , he terogeneity, and dynam ics o ft hese pr otein s havey et t o b ede ter mi n ed . Fin din g thisorganizati onis  key to unde r st anding how  pr oteins regul ate  these  s yst e ms in  he althy  cells and mi ght malfu nc t ion in disease . Th us,we aim to map key pr o teins proposed  to ac td ur i n g e xoc ytosis inen docri n e", "underscore_trick": ", biochemistry,_and electrophysiology._However, the spatial organization,_heterogeneity, and_dynamics_of these_proteins_have yet to_be determined. Finding_this organization is key_to understanding how_proteins_regulate these systems in healthy cells and might malfunction in disease. Thus, we aim_to_map key_proteins_proposed_to act during exocytosis in_endocrine"}
{"text": ", and TLR7. Exposure of monocytes to mf resulted in significant inhibition of the phagocytic ability of these cells to the same degree as that seen with IL-4. Our data suggest that short exposure of human monocytes to IL-4 induces a phenotypic characteristic of alternative activation and that secreted filarial products skew monocytes similarly", "synonym_substitution": ", and TLR7. Exposure of monocytes to mf resulted in significant prohibition of the phagocytic ability of these cell to the same degree as that witness with IL-4. Our datum suggest that short exposure of human monocyte to IL-4 induce a phenotypic feature of alternate activation and that secreted filarial product skew monocytes similarly", "butter_fingers": ", anf TLR7. Exposure of monocyues to mf resulteb in sijnificaht inhibktion of the phagocytic abilmty if thtfe cells to the saoe degree as that seei with IL-4. Our davz suggest thaf shoxt exposure of homan monocytas to IL-4 inducas a phenotypic characteristic of altergative schivation and trat xqcrefvd filarial products skew monocgtes sikilarly", "random_deletion": ", and TLR7. Exposure of monocytes to in inhibition of phagocytic ability of degree that seen with Our data suggest short exposure of human monocytes to induces a phenotypic characteristic of alternative activation and that secreted filarial products skew similarly", "change_char_case": ", and TLR7. Exposure of monocytes To mf resultEd in sIgnIfiCaNt inHibiTion of the phagoCYtic Ability of these cells to tHe samE dEGree AS tHat seEn with Il-4. ouR DAta SuGgEst ThAT sHort eXpoSure of hUman monocyTes To iL-4 induces a phENoTypic charaCteRistic of alteRnaTive acTiVatIOn and ThaT secrEted fiLArial pRoducts skEw MOnocytES similaRLY", "whitespace_perturbation": ", and TLR7. Exposure of mo nocytes to  mf r esu lte din s igni ficant inhibit i on o f the phagocytic abili ty of  t h esec el ls to  the sa m ed e gre eas  th at se en wi thIL-4. O ur data su gge st  that shorte xp osure of h uma n monocytestoIL-4 i nd uce s  a ph eno typic  chara c terist ic of alt er n ativea ctivati o n  a nd t hat secreted fila r ia l  products skew  monoc yt e ss i mil arl y", "underscore_trick": ", and_TLR7. Exposure_of monocytes to mf_resulted in_significant_inhibition of_the_phagocytic ability of_these cells to_the same degree as_that seen with_IL-4._Our data suggest that short exposure of human monocytes to IL-4 induces a phenotypic_characteristic_of alternative_activation_and_that secreted filarial products skew_monocytes similarly"}
{"text": ", exercise, or significant stress. We aim to determine whether variants in the IGD genes are over-represented in individuals with HA, compared to the general population, using controls from the ClinSeq study (Biesecker, LG, et al, Genome Res, 2009). If the data support our hypothesis, as", "synonym_substitution": ", exercise, or significant stress. We aim to settle whether random variable in the IGD genes are over - represented in individual with HA, compared to the general population, use control from the ClinSeq study (Biesecker, LG, et al, Genome Res, 2009). If the data support our hypothesis, as", "butter_fingers": ", exfrcise, or significant stvess. We aim to dgtwrmine whethsr variavts in the IGD genes are ovec-repeesenuvd in individuals witf HA, compwred to rhe jeneral population, using contrkps fxon the ClinSeq xtudy (Biesacker, LG, et al, Gdnlme Res, 2009). If the data support our hy[othesix, ws", "random_deletion": ", exercise, or significant stress. We aim whether in the genes are over-represented to general population, using from the ClinSeq (Biesecker, LG, et al, Genome Res, If the data support our hypothesis, as", "change_char_case": ", exercise, or significant streSs. We aim to dEtermIne WheThEr vaRianTs in the IGD geneS Are oVer-represented in indiviDuals WiTH HA, cOMpAred tO the genERaL POpuLaTiOn, uSiNG cOntroLs fRom the CLinSeq studY (BiEsEcker, LG, et al, GENoMe Res, 2009). If the DatA support our hYpoThesis, As", "whitespace_perturbation": ", exercise, or significant  stress. W e aim  to  de te rmin e wh ether variants in t he IGD genes are over- repre se n tedi nindiv idualsw it h HA,  c om par ed to  thegen eral po pulation,usi ng  controls fr o mthe ClinSe q s tudy (Biesec ker , LG,et  al ,  Geno meRes,2009). If the  data sup po r t ourh ypothes i s ,as", "underscore_trick": ", exercise,_or significant_stress. We aim to_determine whether_variants_in the_IGD_genes are over-represented_in individuals with_HA, compared to the_general population, using_controls_from the ClinSeq study (Biesecker, LG, et al, Genome Res, 2009). If the data_support_our hypothesis,_as"}
{"text": " mediated by Wnt, Hedgehog, Notch, BMP and EphB/ephrin are restricted spatially along the crypt-villus axis in the epithelium and the mesenchyme of the intestine. Below position +4 (where the self-renewing Lgr5+ stem cells reside with Paneth cells) in", "synonym_substitution": "mediated by Wnt, Hedgehog, Notch, BMP and EphB / ephrin are restricted spatially along the crypt - villus axis in the epithelium and the mesenchyme of the intestine. Below position +4 (where the self - regenerate Lgr5 + shank cells reside with Paneth cells) in", "butter_fingers": " mefiated by Wnt, Hedgehog, Nutch, BMP and EpkV/ephrii are rsstrictea spatially along the crypt-vmlluw axiw in the epithelium ana the mesvnchyme od tht intestine. Below positiok +4 (whsve thz welf-renewing Lnr5+ stem celns reside with Pxnzth cells) in", "random_deletion": "mediated by Wnt, Hedgehog, Notch, BMP and restricted along the axis in the the Below position +4 the self-renewing Lgr5+ cells reside with Paneth cells) in", "change_char_case": " mediated by Wnt, Hedgehog, NotcH, BMP and Ephb/ephrIn aRe rEsTricTed sPatially along tHE cryPt-villus axis in the epithElium AnD The mESeNchymE of the iNTeSTIne. beLoW poSiTIoN +4 (wherE thE self-reNewing Lgr5+ sTem CeLls reside witH paNeth cells) iN", "whitespace_perturbation": " mediated by Wnt, Hedgehog , Notch, B MP an d E phB /e phri n ar e restricted s p atia lly along the crypt-vi llusax i s in th e epi thelium an d the  m es enc hy m eof th e i ntestin e. Below p osi ti on +4 (where th e self-ren ewi ng Lgr5+ ste m c ells r es ide withPan eth c ells)i n", "underscore_trick": " mediated_by Wnt,_Hedgehog, Notch, BMP and_EphB/ephrin are_restricted_spatially along_the_crypt-villus axis in_the epithelium and_the mesenchyme of the_intestine. Below position_+4_(where the self-renewing Lgr5+ stem cells reside with Paneth cells) in"}
{"text": " mathematical modeling of these signaling processes in eukaryotic cells, on how the antigen receptors (TCR) of T lymphocytes are selected to provide maximally effective responses to infectious agents, and on how variations in the magnitude and quality of TCR-associated signaling events influence the qualitative nature of adaptive immune responses. We previously reported our analysis of", "synonym_substitution": "mathematical modeling of these signaling processes in eukaryotic cell, on how the antigen receptor (TCR) of T lymphocytes are selected to provide maximally effective reaction to infectious agents, and on how variations in the order of magnitude and quality of TCR - associated signaling event influence the qualitative nature of adaptive immune responses. We previously report our analysis of", "butter_fingers": " mahhematical modeling of tmese signaling ptoxesses in euiaryotic cells, on how the antigen rereptirs (TXR) of T lymphocytes ard selectef to procide naximally xrfectivc resllnsev to infectious agents, ang on how variadiund in the magnitude and quality of TSR-assocoahed signaling gventx infmlekce the qualitative nature of adzptive pmmune responses. Ee previously reported our anapysis of", "random_deletion": "mathematical modeling of these signaling processes in on the antigen (TCR) of T maximally responses to infectious and on how in the magnitude and quality of signaling events influence the qualitative nature of adaptive immune responses. We previously reported analysis of", "change_char_case": " mathematical modeling of theSe signalinG procEssEs iN eUkarYotiC cells, on how the ANtigEn receptors (TCR) of T lymphOcyteS aRE selECtEd to pRovide mAXiMALly EfFeCtiVe REsPonseS to InfectiOus agents, aNd oN hOw variations IN tHe magnitudE anD quality of TCr-asSociatEd SigNAling EveNts inFluencE The quaLitative nAtURe of adAPtive imMUNe RespOnses. We previously REpORted our analysiS of", "whitespace_perturbation": " mathematical modeling ofthese sign aling  pr oce ss es i n eu karyotic cells ,  onhow the antigen recept ors ( TC R ) of Tlymph ocytesa re s ele ct ed  to  p r ov ide m axi mally e ffective r esp on ses to infec t io us agents,  an d on how var iat ions i nthe magni tud e and  quali t y of T CR-associ at e d sign a ling ev e n ts  inf luence the qualit a ti v e nature of ad aptive  i m mu n e  re spo nses. We p re vious l y repor t ed o u r a n alysis of", "underscore_trick": " mathematical_modeling of_these signaling processes in_eukaryotic cells,_on_how the_antigen_receptors (TCR) of_T lymphocytes are_selected to provide maximally_effective responses to_infectious_agents, and on how variations in the magnitude and quality of TCR-associated signaling events_influence_the qualitative_nature_of_adaptive immune responses. We previously_reported our analysis of"}
{"text": " superfamilies, the type I cytokine receptor superfamily (IL-6R), the interleukin 1/Toll-like receptor family (IL-1RII) and the TNF receptor superfamily (TNFR1). We have also identified that TNFR1 can be released from human vascular endothelial cells into the extracellular compartment", "synonym_substitution": "superfamilies, the type I cytokine receptor superfamily (IL-6R), the interleukin 1 / Toll - alike sense organ family (IL-1RII) and the TNF receptor superfamily (TNFR1). We have besides identified that TNFR1 can be release from human vascular endothelial cells into the extracellular compartment", "butter_fingers": " suoerfamilies, the type I cntokine receptor superfemily (IM-6R), the ivterleukin 1/Toll-like receptor fqmily (IL-1RII) and the TNF recdptor supvrfamily (RNFR1). Qe have also identlyied fmat TUFC1 can be releasgd from humat vascular endmtfepial cells into the extracellular cjmpartmrnh", "random_deletion": "superfamilies, the type I cytokine receptor superfamily interleukin receptor family and the TNF also that TNFR1 can released from human endothelial cells into the extracellular compartment", "change_char_case": " superfamilies, the type I cytoKine receptOr supErfAmiLy (iL-6R), tHe inTerleukin 1/Toll-lIKe reCeptor family (IL-1RII) and thE TNF rEcEPtor SUpErfamIly (TNFR1). wE hAVE alSo IdEntIfIEd That TnFR1 Can be reLeased from HumAn Vascular endoTHeLial cells iNto The extracellUlaR compaRtMenT", "whitespace_perturbation": " superfamilies, the type I  cytokinerecep tor  su pe rfam ily(IL-6R), the i n terl eukin 1/Toll-like rece ptorfa m ily( IL -1RII ) and t h eT N F r ec ep tor  s u pe rfami ly(TNFR1) . We haveals oidentified t h at  TNFR1 can  be  released fr omhumanva scu l ar en dot helia l cell s  intothe extra ce l lularc ompartm e n t", "underscore_trick": " superfamilies,_the type_I cytokine receptor superfamily_(IL-6R), the_interleukin_1/Toll-like receptor_family_(IL-1RII) and the_TNF receptor superfamily_(TNFR1). We have also_identified that TNFR1_can_be released from human vascular endothelial cells into the extracellular compartment"}
{"text": " KS phenotype. Functional validation of the role of this gene in IGD is being performed in collaboration with Dr. Susan Wray, NINDS. In addition, through our collaboration with the REU at MGH, we have also performed ES in several families with IGD and known uterine anomalies, and we have enrolled", "synonym_substitution": "KS phenotype. Functional validation of the role of this gene in IGD is being performed in collaboration with Dr. Susan Wray, NINDS. In accession, through our collaboration with the REU at MGH, we have besides performed ES in several class with IGD and know uterine anomalies, and we have enrolled", "butter_fingers": " KS phenotype. Functional vauidation of the role oh this fene in KGD is being performed in coplqboraupon with Dr. Susan Wrah, NINDS. Ij additiin, tirough our collaukration with fme REB et MGH, we have slso perfosmed ES in sevarxl families with IGD and known uterinq anomakifs, and we have enrpjled", "random_deletion": "KS phenotype. Functional validation of the role gene IGD is performed in collaboration In through our collaboration the REU at we have also performed ES in families with IGD and known uterine anomalies, and we have enrolled", "change_char_case": " KS phenotype. Functional valiDation of thE role Of tHis GeNe in iGD iS being performeD In coLlaboration with Dr. Susan wray, NiNds. In aDDiTion, tHrough oUR cOLLabOrAtIon WiTH tHe REU At MgH, we havE also perfoRmeD Es in several faMIlIes with IGD And Known uterine AnoMalies, AnD we HAve enRolLed", "whitespace_perturbation": " KS phenotype. Functionalvalidation  of t herol eof t hisgene in IGD is bein g performed in collabo ratio nw ithD r.  Susa n Wray, NI N D S.In  a ddi ti o n,  thro ugh  our co llaboratio n w it h the REU at MG H, we have  al so performed  ES  in se ve ral famil ies  with  IGD a n d know n uterine  a n omalie s , and w e ha ve e nrolled", "underscore_trick": " KS_phenotype. Functional_validation of the role_of this_gene_in IGD_is_being performed in_collaboration with Dr._Susan Wray, NINDS. In_addition, through our_collaboration_with the REU at MGH, we have also performed ES in several families with_IGD_and known_uterine_anomalies,_and we have enrolled"}
{"text": ", cell cycle, DNA repair, detoxication and cytoskeleton biogenesis. We conclude from these data that tumor development in c-Myc/Tgfαmice results from a progressive accumulation of genetic alterations which culminate in HCC. Furthermore, our results strongly suggest that a disruption of the innate", "synonym_substitution": ", cell cycle, DNA repair, detoxication and cytoskeleton biosynthesis. We reason from these datum that tumor development in c - Myc / Tgfαmice results from a progressive accumulation of genic alterations which culminate in HCC. Furthermore, our results powerfully suggest that a disruption of the innate", "butter_fingers": ", cepl cycle, DNA repair, detowication and cytoskeletmn biofenesis. De conclude from these data vhat tumoe development in c-Myc/Tefαmice results fron a progressive accmiulaflon oy jenetic alteratlons which wulminate in HWC. Fbrthermore, our results strongly suggqst thay w disruption os tht ignats", "random_deletion": ", cell cycle, DNA repair, detoxication and We from these that tumor development progressive of genetic alterations culminate in HCC. our results strongly suggest that a of the innate", "change_char_case": ", cell cycle, DNA repair, detoxicAtion and cyToskeLetOn bIoGeneSis. WE conclude from tHEse dAta that tumor developmenT in c-MYc/tGf&amP;#945;MiCe resUlts froM A pROGreSsIvE acCuMUlAtion Of gEnetic aLterations WhiCh Culminate in Hcc. FUrthermore, Our Results stronGly SuggesT tHat A DisruPtiOn of tHe innaTE", "whitespace_perturbation": ", cell cycle, DNA repair,detoxicati on an d c yto sk elet on b iogenesis. Wec oncl ude from these data th at tu mo r  dev e lo pment  in c-M y c/ T g f&a mp ;# 945 ;m i ce  resu lts  from a  progressi veac cumulation o f  g enetic alt era tions whichcul minate  i n H C C. Fu rth ermor e, our result s strongl ys uggest that ad i sr upti on of the innate", "underscore_trick": ", cell_cycle, DNA_repair, detoxication and cytoskeleton_biogenesis. We_conclude_from these_data_that tumor development_in c-Myc/Tgfαmice results_from a progressive accumulation_of genetic alterations_which_culminate in HCC. Furthermore, our results strongly suggest that a disruption of the innate"}
{"text": " only be determined by administration to human volunteers. In the meantime, we explored an additional method of administration, namely by aerosol generated using a nebulizer. This method has been successfully and safely used in large-scale immunization against measles virus. This method of administration proved to be immunogenic and highly protective in AGM,", "synonym_substitution": "only be determined by administration to human volunteers. In the interim, we explore an additional method of presidency, namely by aerosol render using a nebulizer. This method acting has been successfully and safely used in large - scale immunization against measles virus. This method acting of presidency proved to be immunogenic and highly protective in AGM,", "butter_fingers": " onpy be determined by admikistration to human volnnteers. In the oeantime, we explored an addivionql meukod of administratiov, namely hy aerosil gtnerated using a isbulizev. Thia metkov has been succgssfully and safely used it uaxge-scale immunization against measlef virus. Tjis method of wdmimystrzniin proved to be immunogenic ahd highny protective in AGM,", "random_deletion": "only be determined by administration to human the we explored additional method of using nebulizer. This method been successfully and used in large-scale immunization against measles This method of administration proved to be immunogenic and highly protective in AGM,", "change_char_case": " only be determined by adminisTration to hUman vOluNteErS. In tHe meAntime, we explorED an aDditional method of adminIstraTiON, namELy By aerOsol genERaTED usInG a NebUlIZeR. This MetHod has bEen successFulLy And safely useD In Large-scale ImmUnization agaInsT measlEs VirUS. This MetHod of AdminiSTratioN proved to Be IMmunogENic and hIGHlY proTective in AGM,", "whitespace_perturbation": " only be determined by adm inistratio n tohum anvo lunt eers . In the meant i me,we explored an additio nal m et h od o f  a dmini stratio n ,n a mel yby  ae ro s ol  gene rat ed usin g a nebuli zer .This methodh as  been succ ess fully and sa fel y used  i n l a rge-s cal e imm unizat i on aga inst meas le s  virus .  This m e t ho d of  administration p r ov e d to be immuno genican d  h i g hly  pr otective i nAGM,", "underscore_trick": " only_be determined_by administration to human_volunteers. In_the_meantime, we_explored_an additional method_of administration, namely_by aerosol generated using_a nebulizer. This_method_has been successfully and safely used in large-scale immunization against measles virus. This method_of_administration proved_to_be_immunogenic and highly protective in_AGM,"}
{"text": " BOLD fMRI on WM in controls. Carriers of risk alleles showed inefficiency in processing in DLPFC. We showed epistasis between SNPs inNRG1 and ErbB4 and a 3-way interaction between NRG1 and SNPs in ErbB4 and AKT1. Each of these interactions (", "synonym_substitution": "BOLD fMRI on WM in controls. Carriers of hazard allele show inefficiency in processing in DLPFC. We showed hypostasis between SNPs inNRG1 and ErbB4 and a 3 - room interaction between NRG1 and SNPs in ErbB4 and AKT1. Each of these interactions (", "butter_fingers": " BOPD fMRI on WM in controlr. Carriers of rnwk allxles shkwed inewficiency in processing in DPPDC. We showed epistasis betwden SNPs pnNRG1 and ErbU4 and a 3-way inteczction nztweeh NRG1 end SNPs in ErbN4 and AKT1. Edch of these ittdrcctions (", "random_deletion": "BOLD fMRI on WM in controls. Carriers alleles inefficiency in in DLPFC. We and and a 3-way between NRG1 and in ErbB4 and AKT1. Each of interactions (", "change_char_case": " BOLD fMRI on WM in controls. CarRiers of risK alleLes ShoWeD ineFficIency in processINg in dLPFC. We showed epistasis BetweEn snPs iNnRg1 and ERbB4 and a 3-WAy INTerAcTiOn bEtWEeN NRG1 aNd SnPs in ErBB4 and AKT1. EaCh oF tHese interactIOnS (", "whitespace_perturbation": " BOLD fMRI on WM in contro ls. Carrie rs of  ri skal lele s sh owed inefficie n cy i n processing in DLPFC.  We s ho w ed e p is tasis  betwee n  S N P s i nN RG 1 a nd Er bB4 a nda 3-way  interacti onbe tween NRG1 a n dSNPs in Er bB4  and AKT1. E ach  of th es e i n terac tio ns (", "underscore_trick": " BOLD_fMRI on_WM in controls. Carriers_of risk_alleles_showed inefficiency_in_processing in DLPFC._We showed epistasis_between SNPs inNRG1 and_ErbB4 and a_3-way_interaction between NRG1 and SNPs in ErbB4 and AKT1. Each of these interactions ("}
{"text": " interventions have the potential to reverse age-related decline. There was minimal transfer of training effects to everyday activities (i.e., functional competence). However, it should be noted that through the two- year followup, there was no evidence of a significant decline in ADL and IADL status. Therefore, to", "synonym_substitution": "interventions have the potential to reverse old age - relate decline. There was minimal transfer of education effects to everyday activities (i.e., running competence). However, it should be note that through the two- year follow-up, there was no evidence of a significant descent in ADL and IADL status. Therefore, to", "butter_fingers": " inherventions have the pottntial to reverse age-releted dedline. Thdre was minimal transfer of vraibing tyfects to everyday aztivities (i.e., funcrionel competence). Hoxsver, it shouls be uoved that througm the two- yaar followup, tvefe was no evidence of a significant dqcline on ADL and IADL ftatls. Thedvfire, to", "random_deletion": "interventions have the potential to reverse age-related was transfer of effects to everyday it be noted that the two- year there was no evidence of a decline in ADL and IADL status. Therefore, to", "change_char_case": " interventions have the potenTial to reveRse agE-reLatEd DeclIne. THere was minimal TRansFer of training effects to EveryDaY ActiVItIes (i.e., FunctioNAl COMpeTeNcE). HoWeVEr, It shoUld Be noted That througH thE tWo- year followUP, tHere was no eVidEnce of a signiFicAnt decLiNe iN aDL anD IAdL staTus. TheREfore, tO", "whitespace_perturbation": " interventions have the po tential to  reve rse  ag e- rela teddecline. There wasminimal transfer of tr ainin ge ffec t sto ev erydaya ct i v iti es  ( i.e ., fu nctio nal  compet ence). How eve r,  it should b e  n oted thatthr ough the two - y ear fo ll owu p , the rewas n o evid e nce of  a signif ic a nt dec l ine inA D LandIADL status. Ther e fo r e, to", "underscore_trick": " interventions_have the_potential to reverse age-related_decline. There_was_minimal transfer_of_training effects to_everyday activities (i.e.,_functional competence). However, it_should be noted_that_through the two- year followup, there was no evidence of a significant decline in_ADL_and IADL_status._Therefore,_to"}
{"text": " of 30 protein associate with clathrin-coated sites in these cells. This information provided us with a molecular framework to understand the regulation of endocytosis in these cells. Next, we developed a new super-resolution correlative light and electron microscopy imaging method. This development allows us to image the nanometer-scale location", "synonym_substitution": "of 30 protein associate with clathrin - coated sites in these cells. This data provide us with a molecular framework to understand the rule of endocytosis in these cells. Next, we develop a new ace - resolution correlative light and electron microscopy imaging method. This growth allows us to image the nanometer - plate location", "butter_fingers": " of 30 protein associate with clathrin-coated sites mn thess cells. Ghis information provided us wuth a molecular framework tu understwnd the eeguoqtion of eisocytoslf in bhese rells. Next, we dgveloped a naw super-resoludiun correlative light and electron micwoscopy ilaging method. Jhis cqvelkimtnt allows us to image the nanomefer-scalt location", "random_deletion": "of 30 protein associate with clathrin-coated sites cells. information provided with a molecular of in these cells. we developed a super-resolution correlative light and electron microscopy method. This development allows us to image the nanometer-scale location", "change_char_case": " of 30 protein associate with claThrin-coateD siteS in TheSe CellS. ThiS information prOVideD us with a molecular frameWork tO uNDersTAnD the rEgulatiON oF ENdoCyToSis In THeSe celLs. NExt, we deVeloped a neW suPeR-resolution cORrElative ligHt aNd electron miCroScopy iMaGinG MethoD. ThIs devElopmeNT allowS us to imagE tHE nanomETer-scalE LOcAtioN", "whitespace_perturbation": " of 30 protein associate w ith clathr in-co ate d s it es i n th ese cells. Thi s  inf ormation provided us w ith a  m o lecu l ar  fram ework t o  u n d ers ta nd  th er eg ulati onof endo cytosis in  th es e cells. Nex t ,we develop eda new super- res olutio ncor r elati velight  and e l ectron  microsco py imagin g  method . Th is d evelopment allows us to image the n anomet er - sc a l e l oca tion", "underscore_trick": " of_30 protein_associate with clathrin-coated sites_in these_cells._This information_provided_us with a_molecular framework to_understand the regulation of_endocytosis in these_cells._Next, we developed a new super-resolution correlative light and electron microscopy imaging method. This_development_allows us_to_image_the nanometer-scale location"}
{"text": "iffer environments) is thought to underly many biological processes including angiogenesis, neurogenesis and cancer metastasis. ECM stiffness sensing is achieved by integrin-mediated focal adhesions (FA), protein assemblies that couple contractile actomyosin bundles to the plasma membrane and transmit force generated by the cytoskeleton to the ECM. Although it has been", "synonym_substitution": "iffer environments) is thought to underly many biological processes including angiogenesis, neurogenesis and cancer metastasis. ECM stiffness detection is achieve by integrin - mediate focal adhesions (FA), protein forum that couple contractile actomyosin bundle to the plasma membrane and transmit force beget by the cytoskeleton to the ECM. Although it has been", "butter_fingers": "ifffr environments) is thougmt to underly maut biolmgical processds including angiogenesis, nenrogwnesiw and cancer metastasir. ECM stivfness swnsiig is achieved bb integrlu-medizbed fmral adhesions (FS), protein dssemblies thad zobple contractile actomyosin bundles eo the llwsma membrane wnd uragsmif force generated by the cytoskelefon to uhe ECM. Although iy has been", "random_deletion": "iffer environments) is thought to underly many including neurogenesis and metastasis. ECM stiffness focal (FA), protein assemblies couple contractile actomyosin to the plasma membrane and transmit generated by the cytoskeleton to the ECM. Although it has been", "change_char_case": "iffer environments) is thoughT to underly Many bIolOgiCaL proCessEs including angIOgenEsis, neurogenesis and canCer meTaSTasiS. eCm stifFness seNSiNG Is aChIeVed By INtEgrin-MedIated foCal adhesioNs (Fa), pRotein assembLIeS that couplE coNtractile actOmyOsin buNdLes TO the pLasMa memBrane aND transMit force gEnERated bY The cytoSKElEton To the ECM. Although iT HaS Been", "whitespace_perturbation": "iffer environments) is tho ught to un derly  ma nybi olog ical  processes inc l udin g angiogenesis, neurog enesi sa nd c a nc er me tastasi s .E C M s ti ff nes ss en singisachieve d by integ rin -m ediated foca l  a dhesions ( FA) , protein as sem bliesth atc ouple  co ntrac tile a c tomyos in bundle st o thep lasma m e m br aneand transmit forc e  g e nerated by the  cytos ke l et o n  to  th e ECM. Alt ho ugh i t  has be e n", "underscore_trick": "iffer environments)_is thought_to underly many biological_processes including_angiogenesis,_neurogenesis and_cancer_metastasis. ECM stiffness_sensing is achieved_by integrin-mediated focal adhesions_(FA), protein assemblies_that_couple contractile actomyosin bundles to the plasma membrane and transmit force generated by the_cytoskeleton_to the_ECM._Although_it has been"}
{"text": " the first dose was reduced 10-15 fold compared to the response in control animals that were HPIV3-nave. However, the serum antibody responses following the second dose were indistinguishable in HPIV3-immune versus HPIV3-naive animals. Thus, an HPIV3-based vector was substantially immun", "synonym_substitution": "the first dose was reduced 10 - 15 fold compare to the reception in control animals that were HPIV3 - nave. However, the serum antibody responses postdate the second dose were indistinguishable in HPIV3 - immune versus HPIV3 - primitive animals. Thus, an HPIV3 - establish vector was substantially immun", "butter_fingers": " thf first dose was reduced 10-15 fold compared to the respohse in cuntrol animals that were HPIT3-navw. Howtner, the serum antibodh responsvs followung uhe second dose wxde indistingujdhabnx in HPIV3-immune versus HPHV3-naive animalv. Ghbs, an HPIV3-based vector was substantiwlly imkuj", "random_deletion": "the first dose was reduced 10-15 fold the in control that were HPIV3-nave. following second dose were in HPIV3-immune versus animals. Thus, an HPIV3-based vector was immun", "change_char_case": " the first dose was reduced 10-15 folD compared tO the rEspOnsE iN conTrol Animals that werE hPIV3-Nave. However, the serum antIbody ReSPonsES fOllowIng the sECoND DosE wErE inDiSTiNguisHabLe in HPIv3-immune verSus hPiV3-naive animaLS. THus, an HPIV3-bAseD vector was suBstAntialLy ImmUN", "whitespace_perturbation": " the first dose was reduce d 10-15 fo ld co mpa red  t o th e re sponse in cont r ol a nimals that were HPIV3 -nave .H owev e r,  theserum a n ti b o dyre sp ons es fo llowi ngthe sec ond dose w ere  i ndistinguish a bl e in HPIV3 -im mune versusHPI V3-nai ve  an i mals.  Th us, a n HPIV 3 -based  vector w as substa n tiallyi m mu n", "underscore_trick": " the_first dose_was reduced 10-15 fold_compared to_the_response in_control_animals that were_HPIV3-nave. However, the_serum antibody responses following_the second dose_were_indistinguishable in HPIV3-immune versus HPIV3-naive animals. Thus, an HPIV3-based vector was substantially immun"}
{"text": ", late TGF-beta signature accurately predicted liver metastasis and discriminated HCC cell lines by degree of invasiveness. In addition, the TGF-beta gene expression signature possessed a predictive value for tumors other than HCC. These data demonstrate the clinical significance of the genes embedded in the TGF-beta expression signature for the molecular classification of HCC", "synonym_substitution": ", late TGF - beta signature accurately predicted liver metastasis and discriminated HCC cellular telephone line by degree of invasiveness. In addition, the TGF - beta gene formula key signature possessed a predictive value for tumors early than HCC. These data demonstrate the clinical significance of the gene implant in the TGF - beta expression key signature for the molecular classification of HCC", "butter_fingers": ", lahe TGF-beta signature accmrately predicteb liver metasfasis ana discriminated HCC cell linxs bt degeee of invasiveness. In addition, the TGF-veta tene expression sinuaturs posvxssed a predictlve value fmr tumors othes ghcn HCC. These data demonstrate the clynical xihnificance of jhe gtnef emgvdbed in the TGF-beta expression sjgnaturt for the moleculat classification of HCC", "random_deletion": ", late TGF-beta signature accurately predicted liver discriminated cell lines degree of invasiveness. expression possessed a predictive for tumors other HCC. These data demonstrate the clinical of the genes embedded in the TGF-beta expression signature for the molecular classification HCC", "change_char_case": ", late TGF-beta signature accurAtely prediCted lIveR meTaStasIs anD discriminated hcC ceLl lines by degree of invasIveneSs. iN addITiOn, the tGF-beta GEnE EXprEsSiOn sIgNAtUre poSseSsed a prEdictive vaLue FoR tumors other THaN HCC. These dAta Demonstrate tHe cLinicaL sIgnIFicanCe oF the gEnes emBEdded iN the TGF-beTa EXpressIOn signaTURe For tHe molecular classiFIcATion of HCC", "whitespace_perturbation": ", late TGF-beta signatureaccurately  pred ict edli vermeta stasis and dis c rimi nated HCC cell lines b y deg re e  ofi nv asive ness. I n  a d d iti on ,the  T G F- betagen e expre ssion sign atu re  possessed a pr edictive v alu e for tumors  ot her th an  HC C . The sedatademons t rate t he clinic al signif i cance o f th e ge nes embedded in t h eT GF-beta expres sion s ig n at u r e f orthe molecu la r cla s sificat i on o f  HC C ", "underscore_trick": ", late_TGF-beta signature_accurately predicted liver metastasis_and discriminated_HCC_cell lines_by_degree of invasiveness._In addition, the_TGF-beta gene expression signature_possessed a predictive_value_for tumors other than HCC. These data demonstrate the clinical significance of the genes_embedded_in the_TGF-beta_expression_signature for the molecular classification_of HCC"}
{"text": " intact target plasmid and found ninety-five percent occurred within a 160 nt region in the ade6 promoter. To determine which sequences of Ade6 were required for efficient integration, we created a series of 10 deletions within the target plasmid. This analysis revealed that the 160 nt region of the promoter was the only sequence that was", "synonym_substitution": "intact target plasmid and found ninety - five percent occur within a 160 national trust region in the ade6 promoter. To settle which sequence of Ade6 were required for efficient consolidation, we created a series of 10 deletions within the prey plasmid. This analysis revealed that the 160 national trust region of the promoter was the only sequence that was", "butter_fingers": " inhact target plasmid and nound ninety-five percenv occurded withkn a 160 nt region in the ade6 pcomorer. Ti determine which sequdnces of Wde6 were reqnired for efficixht intenxatioh, we erxated a series pf 10 deletimns within the txryet plasmid. This analysis revealed trat the 160 jt region of tre pgoioted was the only sequence that was", "random_deletion": "intact target plasmid and found ninety-five percent a nt region the ade6 promoter. Ade6 required for efficient we created a of 10 deletions within the target This analysis revealed that the 160 nt region of the promoter was the sequence that was", "change_char_case": " intact target plasmid and fouNd ninety-fiVe perCenT ocCuRred WithIn a 160 nt region in tHE ade6 Promoter. To determine whiCh seqUeNCes oF adE6 were RequireD FoR EFfiCiEnT inTeGRaTion, wE crEated a sEries of 10 delEtiOnS within the taRGeT plasmid. ThIs aNalysis reveaLed That thE 160 nT reGIon of The PromoTer was THe only Sequence tHaT Was", "whitespace_perturbation": " intact target plasmid and  found nin ety-f ive  pe rc entoccu rred within a1 60 n t region in the ade6 p romot er .  Tod et ermin e which se q u enc es  o f A de 6  w ere r equ ired fo r efficien t i nt egration, we cr eated a se rie s of 10 dele tio ns wit hi n t h e tar get  plas mid. T h is ana lysis rev ea l ed tha t  the 16 0 nt  reg ion of the promot e rw as the only se quence  t h at w as", "underscore_trick": " intact_target plasmid_and found ninety-five percent_occurred within_a_160 nt_region_in the ade6_promoter. To determine_which sequences of Ade6_were required for_efficient_integration, we created a series of 10 deletions within the target plasmid. This analysis_revealed_that the_160_nt_region of the promoter was_the only sequence that was"}
{"text": " scanning microscope specifically designed for studying protein-protein interactions in living cells. The microscope is a fully functional laser scanning two-photon microscope, with the additional capabilities of measuring florescent emission spectra (spectral imaging), fluorescent lifetime decays (FLIM), and fluorescent anisotropy lifetime decays (rFLIM). These added capabilities make it", "synonym_substitution": "scanning microscope specifically designed for studying protein - protein interactions in support cell. The microscope is a fully functional laser scanning two - photon microscope, with the extra capabilities of measuring florescent emission spectra (apparitional imagination), fluorescent lifetime decays (FLIM), and fluorescent anisotropy lifetime decays (rFLIM). These added capability make it", "butter_fingers": " scwnning microscope speciflcally designed yir stuvying pdotein-prutein interactions in living cwlls. Uke microscope is a fjlly funcnional lawer wxanning two-photon microsdlpe, civh the additionsl capabilhties of measusivg florescent emission spectra (spectrwl imagonh), fluorescent jifeuimq dedays (FLIM), and fluorescent anisotroly lifeuime decays (rFLIM). Yhese added capabilities mwke lt", "random_deletion": "scanning microscope specifically designed for studying protein-protein living The microscope a fully functional the capabilities of measuring emission spectra (spectral fluorescent lifetime decays (FLIM), and fluorescent lifetime decays (rFLIM). These added capabilities make it", "change_char_case": " scanning microscope specifiCally desigNed foR stUdyInG proTein-Protein interacTIons In living cells. The microsCope iS a FUlly FUnCtionAl laser SCaNNIng TwO-pHotOn MIcRoscoPe, wIth the aDditional cApaBiLities of measURiNg floresceNt eMission spectRa (sPectraL iMagINg), fluOreScent LifetiME decayS (FLIM), and fLuORescenT AnisotrOPY lIfetIme decays (rFLIM). TheSE aDDed capabilitieS make iT", "whitespace_perturbation": " scanning microscope speci fically de signe d f orst udyi ng p rotein-protein inte ractions in living cel ls. T he micr o sc ope i s a ful l yf u nct io na l l as e rscann ing  two-ph oton micro sco pe , with the a d di tional cap abi lities of me asu ring f lo res c ent e mis sionspectr a  (spec tral imag in g ), flu o rescent l if etim e decays (FLIM),a nd fluorescent an isotro py li f e tim e d ecays (rFL IM ). Th e se adde d  c a p a bil i ties make it", "underscore_trick": " scanning_microscope specifically_designed for studying protein-protein_interactions in_living_cells. The_microscope_is a fully_functional laser scanning_two-photon microscope, with the_additional capabilities of_measuring_florescent emission spectra (spectral imaging), fluorescent lifetime decays (FLIM), and fluorescent anisotropy lifetime decays_(rFLIM)._These added_capabilities_make_it"}
{"text": ", HIV-2 and SIV encoded Vpx counteracts the antiviral effects of SAMHD1 by targeting the protein for proteasomal degradation. In FY13 we initiated a new SAMHD1-related project that addresses the role of post-translational modifications in SAMHD1 for its antiviral activity. We used 32", "synonym_substitution": ", HIV-2 and SIV encoded Vpx counteracts the antiviral effects of SAMHD1 by targeting the protein for proteasomal degradation. In FY13 we initiate a newfangled SAMHD1 - related project that addresses the character of post - translational modifications in SAMHD1 for its antiviral activity. We use 32", "butter_fingers": ", HIG-2 and SIV encoded Vpx comnteracts the anjiciral xffects of SAMHA1 by targeting the protein flr prottcsomal degradation. Iv FY13 we ijitiated a ntw SAMHD1-related pckject tmct adsvessev the role of ppst-transladional modificdtkous in SAMHD1 for its antiviral activiey. We uxef 32", "random_deletion": ", HIV-2 and SIV encoded Vpx counteracts effects SAMHD1 by the protein for initiated new SAMHD1-related project addresses the role post-translational modifications in SAMHD1 for its activity. We used 32", "change_char_case": ", HIV-2 and SIV encoded Vpx counteRacts the anTivirAl eFfeCtS of SaMHD1 By targeting the PRoteIn for proteasomal degradAtion. in fy13 we iNItIated A new SAMhd1-rELAteD pRoJecT tHAt AddreSseS the rolE of post-traNslAtIonal modificATiOns in SAMHD1 For Its antiviral ActIvity. WE uSed 32", "whitespace_perturbation": ", HIV-2 and SIV encoded Vp x countera cts t heant iv iral  eff ects of SAMHD1 by t argeting the protein f or pr ot e asom a ldegra dation. In F Y13  w eini ti a te d a n ewSAMHD1- related pr oje ct  that addres s es  the roleofpost-transla tio nal mo di fic a tions  in  SAMH D1 for its an tiviral a ct i vity.W e used3 2 ", "underscore_trick": ", HIV-2_and SIV_encoded Vpx counteracts the_antiviral effects_of_SAMHD1 by_targeting_the protein for_proteasomal degradation. In_FY13 we initiated a_new SAMHD1-related project_that_addresses the role of post-translational modifications in SAMHD1 for its antiviral activity. We used_32"}
{"text": " (Dlc1neo) were obtained, and the frt-flanked neo cassette was removed by breeding with Flpe transgenic mice, to generate the floxed Dlc1 allele (Dlc1fl) with single loxP sites on both sides of exon 4. Both the Dlc1neo/", "synonym_substitution": "(Dlc1neo) were obtained, and the frt - flanked neo cassette was removed by breeding with Flpe transgenic mouse, to render the floxed Dlc1 allele (Dlc1fl) with single loxP sites on both sides of exon 4. Both the Dlc1neo/", "butter_fingers": " (Dlf1neo) were obtained, and tme frt-flanked neo cassevte was removed by breeding with Flpe transjenix mict, to generate the fuoxed Dlc1 allele (Elc1fo) with single loxP sites kk botk wides of exon 4. Both the Glc1neo/", "random_deletion": "(Dlc1neo) were obtained, and the frt-flanked neo removed breeding with transgenic mice, to (Dlc1fl) single loxP sites both sides of 4. Both the Dlc1neo/", "change_char_case": " (Dlc1neo) were obtained, and the fRt-flanked nEo casSetTe wAs RemoVed bY breeding with FLPe trAnsgenic mice, to generate The flOxED Dlc1 ALlEle (DlC1fl) with SInGLE loXP SiTes On BOtH sideS of Exon 4. BotH the Dlc1neo/", "whitespace_perturbation": " (Dlc1neo) were obtained,and the fr t-fla nke d n eo  cas sett e was removedb y br eeding with Flpe trans genic  m i ce,t ogener ate the fl o x edDl c1  al le l e(Dlc1 fl)  with s ingle loxP  si te s on both si d es  of exon 4 . B oth the Dlc1 neo /", "underscore_trick": " (Dlc1neo)_were obtained,_and the frt-flanked neo_cassette was_removed_by breeding_with_Flpe transgenic mice,_to generate the_floxed Dlc1 allele (Dlc1fl)_with single loxP_sites_on both sides of exon 4. Both the Dlc1neo/"}
{"text": " reproduce those observed in a subset of human HCC with poor prognosis. Our goal is to achieve a comprehensive characterization of the multiple-step tumor progression by profiling gene expression from the early to late stages of HCC development. Significantly, gene expression data were highly consistent with the c-Myc/Tgf&#9", "synonym_substitution": "reproduce those observed in a subset of human HCC with poor prognosis. Our goal is to achieve a comprehensive word picture of the multiple - gradation tumor progression by profiling gene expression from the early to former stages of HCC development. importantly, gene expression data were highly consistent with the c - Myc / Tgf&#9", "butter_fingers": " reoroduce those observed ik a subset of human HCC with loor proenosis. Our goal is to achievx a xomprtkensive characterizagion of tje multiple-suep tumor progression by ixofiljkg geue expression frpm the earny to late stacer lf HCC development. Significantly, gege exprrsdion data were hignjy cknsistent with the c-Myc/Tgf&#9", "random_deletion": "reproduce those observed in a subset of with prognosis. Our is to achieve multiple-step progression by profiling expression from the to late stages of HCC development. gene expression data were highly consistent with the c-Myc/Tgf&#9", "change_char_case": " reproduce those observed in a Subset of huMan HCc wiTh pOoR proGnosIs. Our goal is to aCHievE a comprehensive charactErizaTiON of tHE mUltipLe-step tUMoR PRogReSsIon By PRoFilinG geNe expreSsion from tHe eArLy to late stagES oF HCC develoPmeNt. SignificanTly, Gene exPrEssIOn datA weRe higHly conSIstent With the c-MYc/tGf&#9", "whitespace_perturbation": " reproduce those observedin a subse t ofhum anHC C wi th p oor prognosis. Ourgoal is to achieve a c ompre he n sive ch aract erizati o no f  th emu lti pl e -s tep t umo r progr ession bypro fi ling gene ex p re ssion from  th e early to l ate  stage sofH CC de vel opmen t. Sig n ifican tly, gene  e x pressi o n dataw e re  hig hly consistent wi t ht he c-Myc/Tgf&a mp;#9", "underscore_trick": " reproduce_those observed_in a subset of_human HCC_with_poor prognosis._Our_goal is to_achieve a comprehensive_characterization of the multiple-step_tumor progression by_profiling_gene expression from the early to late stages of HCC development. Significantly, gene expression_data_were highly_consistent_with_the c-Myc/Tgf&#9"}
{"text": " of cargo release from single insulin-containing dense-core vesicles in cultured beta cells. Our hypothesis is that these proteins (dynamin, syndapin, amphiphysin, and endophilin) regulate the dilation of the fusion pore to control the amount of cargo released during single exocytic fusion events in cells", "synonym_substitution": "of cargo release from single insulin - containing dense - core vesicle in civilized beta cellular telephone. Our hypothesis is that these proteins (dynamin, syndapin, amphiphysin, and endophilin) baffle the dilation of the fusion pore to master the measure of cargo released during single exocytic fusion events in cell", "butter_fingers": " of cargo release from singue insulin-contanbing dxnse-cors vesiclds in cultured beta cells. Ouc hypothewis is that these protdins (dynalin, syndqpin, qmphiphysii, and endophiljk) regblete the dilatiok of the fuvion pore to cmngrll the amount of cargo released duryng sinblf exocytic fusyon tvegts jn cells", "random_deletion": "of cargo release from single insulin-containing dense-core cultured cells. Our is that these endophilin) the dilation of fusion pore to the amount of cargo released during exocytic fusion events in cells", "change_char_case": " of cargo release from single iNsulin-contAininG deNse-CoRe veSiclEs in cultured beTA celLs. Our hypothesis is that tHese pRoTEins (DYnAmin, sYndapin, AMpHIPhySiN, aNd eNdOPhIlin) rEguLate the Dilation of The FuSion pore to coNTrOl the amounT of Cargo releaseD duRing siNgLe eXOcytiC fuSion eVents iN Cells", "whitespace_perturbation": " of cargo release from sin gle insuli n-con tai nin gdens e-co re vesicles in cult ured beta cells. Our h ypoth es i s is th at th ese pro t ei n s  (d yn am in,  s y nd apin,  am phiphys in, and en dop hi lin) regulat e  t he dilatio n o f the fusion  po re toco ntr o l the  am ountof car g o rele ased duri ng single exocyti c fu sion  events in cells", "underscore_trick": " of_cargo release_from single insulin-containing dense-core_vesicles in_cultured_beta cells._Our_hypothesis is that_these proteins (dynamin,_syndapin, amphiphysin, and endophilin)_regulate the dilation_of_the fusion pore to control the amount of cargo released during single exocytic fusion_events_in cells"}
{"text": " specific receptors to evoke the effector activities of mature T cells in the body, as well as regulate their growth, inactivation, differentiation, or death. In particular, we want to understand in molecular detail the protein-protein interactions that turn recognition of antigen by T cells into signals guiding the normal survival and effector functions of these", "synonym_substitution": "specific receptors to evoke the effector activities of ripe metric ton cells in the body, as well as baffle their growth, inactivation, specialization, or death. In particular, we want to sympathize in molecular contingent the protein - protein interactions that turn realization of antigen by T cells into signal guide the normal survival and effector function of these", "butter_fingers": " spfcific receptors to evokt the effector acjicities of mafure T cdlls in the body, as well as ceguoate ukeir growth, inactivagion, diffvrentiatiin, oc death. In partirhlar, we want fl unbecstand in molecolar detail dhe protein-prodekn interactions that turn recognition of antogfn by T cells ynto fignzls guiding the normal survival ans effecuor functions of tnese", "random_deletion": "specific receptors to evoke the effector activities T in the as well as or In particular, we to understand in detail the protein-protein interactions that turn of antigen by T cells into signals guiding the normal survival and effector of these", "change_char_case": " specific receptors to evoke tHe effector ActivItiEs oF mAturE T ceLls in the body, as WEll aS regulate their growth, inActivAtIOn, diFFeRentiAtion, or DEaTH. in pArTiCulAr, WE wAnt to UndErstand In moleculaR deTaIl the protein-PRoTein interaCtiOns that turn rEcoGnitioN oF anTIgen bY T cElls iNto sigNAls guiDing the noRmAL surviVAl and efFECtOr fuNctions of these", "whitespace_perturbation": " specific receptors to evo ke the eff ector  ac tiv it iesof m ature T cellsi n th e body, as well as reg ulate  t h eirg ro wth,inactiv a ti o n , d if fe ren ti a ti on, o r d eath. I n particul ar,  w e want to un d er stand in m ole cular detail  th e prot ei n-p r otein  in terac tionst hat tu rn recogn it i on ofa ntigenb y  T  cel ls into signals g u id i ng the normalsurviv al an d eff ect or functio ns  of t h ese", "underscore_trick": " specific_receptors to_evoke the effector activities_of mature_T_cells in_the_body, as well_as regulate their_growth, inactivation, differentiation, or_death. In particular,_we_want to understand in molecular detail the protein-protein interactions that turn recognition of antigen_by_T cells_into_signals_guiding the normal survival and_effector functions of these"}
{"text": " been referred with autoinflammatory disorders presenting early in life, who have clinical similarities with NOMID and DIRA patients but can clinically not be classified. We are using a genetic approach of whole genome sequencing in collaboration with Dr. Kastners group, an immunologic approach to characterize the immune deviation and a treatment approach", "synonym_substitution": "been referred with autoinflammatory disorders presenting early in biography, who take clinical similarities with NOMID and DIRA patients but can clinically not be classified. We are use a genetic approach of unharmed genome sequencing in collaboration with Dr. Kastners group, an immunologic access to characterize the immune deviation and a discussion approach", "butter_fingers": " befn referred with autoinfuammatory disorbwrs prxsentinf early kn life, who have clinical silioaritues with NOMID and DIRX patientd but cab clmnically not be rmassificb. We zve usnnj a genetic apptoach of whone genome sequanziug in collaboration with Dr. Kastners group, sn immunologic akproabh to dharacterize the immune deviation znd a tgeatment approach", "random_deletion": "been referred with autoinflammatory disorders presenting early who clinical similarities NOMID and DIRA be We are using genetic approach of genome sequencing in collaboration with Dr. group, an immunologic approach to characterize the immune deviation and a treatment approach", "change_char_case": " been referred with autoinflaMmatory disOrderS prEseNtIng eArly In life, who have cLInicAl similarities with NOMId and DiRa PatiENtS but cAn cliniCAlLY Not Be ClAssIfIEd. we are UsiNg a geneTic approacH of WhOle genome seqUEnCing in collAboRation with Dr. kasTners gRoUp, aN ImmunOloGic apProach TO charaCterize thE iMMune deVIation aND A tReatMent approach", "whitespace_perturbation": " been referred with autoin flammatory  diso rde rspr esen ting  early in life ,  who  have clinical similar ities  w i th N O MI D and  DIRA p a ti e n tsbu tcan  c l in icall y n ot be c lassified.  We  a re using a g e ne tic approa chof whole gen ome  seque nc ing in co lla borat ion wi t h Dr.Kastnersgr o up, an immunol o g ic  app roach to characte r iz e  the immune de viatio na nd a  tr eat ment appro ac h", "underscore_trick": " been_referred with_autoinflammatory disorders presenting early_in life,_who_have clinical_similarities_with NOMID and_DIRA patients but_can clinically not be_classified. We are_using_a genetic approach of whole genome sequencing in collaboration with Dr. Kastners group, an_immunologic_approach to_characterize_the_immune deviation and a treatment_approach"}
{"text": " percent of the bulk cell population at >2 weeks post-electroporation. Site-specific transgene integration was confirmed by PCR analysis of bulk cell gDNA using reporter- and flanking gene-specific primer pairs. To estimate the frequency of transgene integration, CD34+ cells were plated in a CFU assay and transplanted into NS", "synonym_substitution": "percent of the bulk cell population at > 2 weeks post - electroporation. web site - specific transgene consolidation was confirm by PCR analysis of bulk cell gDNA use reporter- and flanking gene - specific primer pair. To calculate the frequency of transgene integration, CD34 + cells were plated in a CFU assay and transplanted into NS", "butter_fingers": " pegcent of the bulk cell pupulation at >2 wgejs posv-electrkporatiov. Site-specific transgene intxgrarion qas confirmed by PCR avalysis ov bulk cwll jDNA using reporvsr- and njankjkg geue-wpecific primet pairs. To evtimate the fraqjeucy of transgene integration, CD34+ cellf were llwted in a CFU wssaj wnd fgaksplanted into NS", "random_deletion": "percent of the bulk cell population at post-electroporation. transgene integration confirmed by PCR using and flanking gene-specific pairs. To estimate frequency of transgene integration, CD34+ cells plated in a CFU assay and transplanted into NS", "change_char_case": " percent of the bulk cell populAtion at >2 weeKs posT-elEctRoPoraTion. site-specific trANsgeNe integration was confirMed by pCr AnalYSiS of buLk cell gdnA USIng RePoRteR- aND fLankiNg gEne-specIfic primer PaiRs. to estimate thE FrEquency of tRanSgene integraTioN, CD34+ celLs WerE PlateD in A CFU aSsay anD TranspLanted intO Ns", "whitespace_perturbation": " percent of the bulk cellpopulation  at > 2 w eek spost -ele ctroporation.S ite- specific transgene int egrat io n  was co nfirm ed by P C Ra n aly si sofbu l kcellgDN A using  reporter-  an dflanking gen e -s pecific pr ime r pairs. Toest imateth e f r equen cyof tr ansgen e  integ ration, C D3 4 + cell s  were p l a te d in  a CFU assay andt ra n splanted intoNS", "underscore_trick": " percent_of the_bulk cell population at_>2 weeks_post-electroporation._Site-specific transgene_integration_was confirmed by_PCR analysis of_bulk cell gDNA using_reporter- and flanking_gene-specific_primer pairs. To estimate the frequency of transgene integration, CD34+ cells were plated in_a_CFU assay_and_transplanted_into NS"}
{"text": ", and skeletal, neurological and renal anomalies. These additional features may be the key to determining the developmental function of genes implicated in this spectrum of disorders. Our clinical protocol (http://gp.nichd.nih.gov), which is a multicenter study in collaboration with the REU at MGH has identified a", "synonym_substitution": ", and skeletal, neurological and renal anomalies. These additional feature may be the keystone to determining the developmental function of genes entail in this spectrum of disorders. Our clinical protocol (http://gp.nichd.nih.gov), which is a multicenter study in collaboration with the REU at MGH has identify a", "butter_fingers": ", anf skeletal, neurological xnd renal anomalies. Thxse addjtional weatures may be the key to dxterninint the developmental fuvction of genes inplirated in this spxdtrum on diskvders. Iur clinical ptotocol (http://cp.nichd.nih.gov), fhkck is a multicenter study in collaborwtion wotj the REU at MDH hsf idsntified a", "random_deletion": ", and skeletal, neurological and renal anomalies. features be the to determining the in spectrum of disorders. clinical protocol (http://gp.nichd.nih.gov), is a multicenter study in collaboration the REU at MGH has identified a", "change_char_case": ", and skeletal, neurological anD renal anomAlies. theSe aDdItioNal fEatures may be thE Key tO determining the developMentaL fUNctiON oF geneS implicATeD IN thIs SpEctRuM Of DisorDerS. Our cliNical protoCol (HtTp://gp.nichd.nih.GOv), Which is a muLtiCenter study iN coLlaborAtIon WIth thE REu at MGh has idENtifieD a", "whitespace_perturbation": ", and skeletal, neurologic al and ren al an oma lie s.  The se a dditional feat u resmay be the key to dete rmini ng thed ev elopm ental f u nc t i onof  g ene si mp licat edin this  spectrumofdi sorders. Our cl inical pro toc ol (http://g p.n ichd.n ih .go v ), wh ich  is a  multi c enterstudy inco l labora t ion wit h th e RE U at MGH has iden t if i ed a", "underscore_trick": ", and_skeletal, neurological_and renal anomalies. These_additional features_may_be the_key_to determining the_developmental function of_genes implicated in this_spectrum of disorders._Our_clinical protocol (http://gp.nichd.nih.gov), which is a multicenter study in collaboration with the REU at_MGH_has identified_a"}
{"text": " shown that FCR3 parasitized red cells expressing VAR2CSA can be efficiently opsonized by a human monocytic cell line. We have developed a novel procedure testing the ability of various domains to inhibit opsonization by these antibodies. We have thus identified several domains that are important for recognition by anti-", "synonym_substitution": "shown that FCR3 parasitized red cells expressing VAR2CSA can be efficiently opsonize by a human monocytic cellular telephone occupation. We have developed a fresh procedure test the ability of various world to suppress opsonization by these antibodies. We have thus identified several domains that are authoritative for recognition by anti-", "butter_fingers": " shlwn that FCR3 parasitized red cells exprgswing VER2CSA czn be efwiciently opsonized by a humen minocyupc cell line. We have aeveloped a novel proredure testing tis abilibv of bwriobs domains to inmibit opsonhzation by theve autibodies. We have thus identified sederal dpmwins that are ympogtwnt ror recognition by anti-", "random_deletion": "shown that FCR3 parasitized red cells expressing be opsonized by human monocytic cell novel testing the ability various domains to opsonization by these antibodies. We have identified several domains that are important for recognition by anti-", "change_char_case": " shown that FCR3 parasitized reD cells exprEssinG VAr2CSa cAn be EffiCiently opsonizED by a Human monocytic cell line. we havE dEVeloPEd A noveL procedURe TEStiNg ThE abIlITy Of varIouS domainS to inhibit OpsOnIzation by theSE aNtibodies. WE haVe thus identiFieD severAl DomAIns thAt aRe impOrtant FOr recoGnition by AnTI-", "whitespace_perturbation": " shown that FCR3 parasitiz ed red cel ls ex pre ssi ng  VAR 2CSA  can be effici e ntly  opsonized by a humanmonoc yt i c ce l lline.  We hav e  d e v elo pe da n ov e lproce dur e testi ng the abi lit yof various d o ma ins to inh ibi t opsonizati onby the se  an t ibodi es.  We h ave th u s iden tified se ve r al dom a ins tha t ar e im portant for recog n it i on by anti-", "underscore_trick": " shown_that FCR3_parasitized red cells expressing_VAR2CSA can_be_efficiently opsonized_by_a human monocytic_cell line. We_have developed a novel_procedure testing the_ability_of various domains to inhibit opsonization by these antibodies. We have thus identified several_domains_that are_important_for_recognition by anti-"}
{"text": " 2287, 2002);c) addressed the mechanistic differences between the CCR5 and CXCR4 receptors in the agonist-driven receptor signaling, and trafficking (Mol Biol of Cell 14, 3305, 2003), d) showed that in primary leukocytes, agonist driven cell migration and receptor internalization are separable processes (J.", "synonym_substitution": "2287, 2002);c) addressed the mechanistic differences between the CCR5 and CXCR4 receptors in the agonist - drive sense organ signaling, and trafficking (Mol Biol of Cell 14, 3305, 2003), d) testify that in elementary leukocytes, agonist driven cellular telephone migration and receptor internalization are separable processes (J.", "butter_fingers": " 2287, 2002);c) addressed the mechanistlc differences bgtqeen tie CCR5 znd CXCR4 receptors in the agonist-driten eecepujr signaling, and tfaffickinh (Mol Biil oh Cell 14, 3305, 2003), d) showxs that lu prijwry nxukocytes, agonixt driven well migration avd receptor internalization are separwble prpcfsses (J.", "random_deletion": "2287, 2002);c) addressed the mechanistic differences between and receptors in agonist-driven receptor signaling, Cell 3305, 2003), d) that in primary agonist driven cell migration and receptor are separable processes (J.", "change_char_case": " 2287, 2002);c) addressed the mechanistic dIfferences BetweEn tHe CcR5 And CxCR4 rEceptors in the aGOnisT-driven receptor signaliNg, and TrAFficKInG (Mol BIol of CeLL 14, 3305, 2003), d) SHOweD tHaT in PrIMaRy leuKocYtes, agoNist driven CelL mIgration and rECePtor internAliZation are sepAraBle proCeSseS (j.", "whitespace_perturbation": " 2287, 2002);c) addressedthe mechan istic  di ffe re nces  bet ween the CCR5a nd C XCR4 receptors in theagoni st - driv e nrecep tor sig n al i n g,an dtra ff i ck ing ( Mol  Biol o f Cell 14,  33 05 , 2003), d)s ho wed that i n p rimary leuko cyt es, ag on ist drive n c ell m igrati o n andreceptorin t ernali z ation a r e  s epar able processes (J . ", "underscore_trick": " 2287,_2002);c) addressed_the mechanistic differences between_the CCR5_and_CXCR4 receptors_in_the agonist-driven receptor_signaling, and trafficking_(Mol Biol of Cell_14, 3305, 2003),_d)_showed that in primary leukocytes, agonist driven cell migration and receptor internalization are separable_processes_(J."}
{"text": "rontal cortical network oscillations. We found that modification of CA2 activity increased or decreased hippocampal and prefrontal cortical low-gamma oscillations with excitatory and inhibitory DREADDs, respectively, and that CA2 activity inversely modulated hippocampal ripple oscillations. These findings support a role for CA2 in low-gamma generation and ripple modulation", "synonym_substitution": "rontal cortical network oscillations. We found that modification of CA2 natural process increase or decreased hippocampal and prefrontal cortical low - gamma oscillation with excitatory and inhibitory DREADDs, respectively, and that CA2 activity inversely modulated hippocampal ripple oscillation. These findings support a function for CA2 in low - gamma genesis and ripple modulation", "butter_fingers": "ronhal cortical network osclllations. We fouue that modifjcation uf CA2 activity increased or vecrwased hippocampal and prefruntal cornical low-tamme oscillations wmfh excibctory wnd nniibitory DREADDx, respectieely, and that WA2 aetivity inversely modulated hippocam[al ripllf oscillations. Thexq fihdings support a role for CA2 in los-gamma jeneration and tipple modulation", "random_deletion": "rontal cortical network oscillations. We found that CA2 increased or hippocampal and prefrontal and DREADDs, respectively, and CA2 activity inversely hippocampal ripple oscillations. These findings support role for CA2 in low-gamma generation and ripple modulation", "change_char_case": "rontal cortical network osciLlations. We Found ThaT moDiFicaTion Of CA2 activity inCReasEd or decreased hippocampAl and PrEFronTAl CortiCal low-gAMmA OSciLlAtIonS wITh ExcitAtoRy and inHibitory DReADds, Respectively, ANd That CA2 actiVitY inversely moDulAted hiPpOcaMPal riPplE osciLlatioNS. These Findings sUpPOrt a roLE for CA2 iN LOw-GammA generation and ripPLe MOdulation", "whitespace_perturbation": "rontal cortical network os cillations . Wefou ndth at m odif ication of CA2 acti vity increased or decr eased  h i ppoc a mp al an d prefr o nt a l  co rt ic allo w -g ammaosc illatio ns with ex cit at ory and inhi b it ory DREADD s,respectively , a nd tha tCA2 activ ity  inve rselym odulat ed hippoc am p al rip p le osci l l at ions . These findingss up p ort a role for  CA2 i nl ow - g amm a g enerationan d rip p le modu l at i o n ", "underscore_trick": "rontal cortical_network oscillations._We found that modification_of CA2_activity_increased or_decreased_hippocampal and prefrontal_cortical low-gamma oscillations_with excitatory and inhibitory_DREADDs, respectively, and_that_CA2 activity inversely modulated hippocampal ripple oscillations. These findings support a role for CA2_in_low-gamma generation_and_ripple_modulation"}
{"text": " solved this issue by establishing an internal quality assurance program for key reagents and centrally procuring them, qualifying them for use in the validated assay, and then making them available upon request via the DCTD Biomarker's website to the oncology research community. In addition, this website provides access to the validated assay S", "synonym_substitution": "solved this issue by establishing an internal timbre assurance platform for key reagents and centrally procure them, qualify them for use in the validated assay, and then making them available upon request via the DCTD Biomarker's web site to the oncology research community. In addition, this web site provide access to the validate assay S", "butter_fingers": " sopved this issue by estabuishing an intetnql quanity aasurance program for key reagents anv cebtraloy procuring them, qualkfying thvm for usw in rhe validavsd assan, and bhen keking them avaikable upon request via tve DETD Biomarker's website to the oncolody resesrfh community. Ig adcytioh, this website provides access to fhe valpdated assay S", "random_deletion": "solved this issue by establishing an internal program key reagents centrally procuring them, the assay, and then them available upon via the DCTD Biomarker's website to oncology research community. In addition, this website provides access to the validated assay", "change_char_case": " solved this issue by establisHing an inteRnal qUalIty AsSuraNce pRogram for key reAGentS and centrally procuring Them, qUaLIfyiNG tHem foR use in tHE vALIdaTeD aSsaY, aND tHen maKinG them avAilable upoN reQuEst via the DCTd biOmarker's weBsiTe to the oncolOgy ResearCh ComMUnity. in aDditiOn, this WEbsite Provides aCcESs to thE ValidatED AsSay S", "whitespace_perturbation": " solved this issue by esta blishing a n int ern alqu alit y as surance progra m  for  key reagents and cent rally  p r ocur i ng  them , quali f yi n g  th em  f orus e  i n the  va lidated  assay, an d t he n making the m  a vailable u pon  request via  th e DCTD  B iom a rker' s w ebsit e to t h e onco logy rese ar c h comm u nity. I n ad diti on, this websitep ro v ides access to  the v al i da t e d a ssa y S", "underscore_trick": " solved_this issue_by establishing an internal_quality assurance_program_for key_reagents_and centrally procuring_them, qualifying them_for use in the_validated assay, and_then_making them available upon request via the DCTD Biomarker's website to the oncology research_community._In addition,_this_website_provides access to the validated_assay S"}
{"text": " been implicated in susceptibility to bipolar disorder. Frustrated in our attempts to confirm a published report that the vertebrate ortholog functions as a non-selective cation channel, we have been unable to ask whether channel function is affected by anesthetics. Instead, we have pursued the functional anatomy of channel's contribution to anesthetic sensitivity. The", "synonym_substitution": "been implicated in susceptibility to bipolar disorder. Frustrated in our attempts to confirm a publish reputation that the vertebrate ortholog functions as a non - selective cation channel, we have been unable to necessitate whether channel function is affected by anesthetic. rather, we have pursued the running human body of channel's contribution to anesthetic sensitivity. The", "butter_fingers": " befn implicated in susceptlbility to bipolce disocder. Frhstrated in our attempts to confirm e puvlishtb report that the veftebrate lrtholog funrtions as a non-sxmective catioh chaunxl, we have been unable to ask whether cvavnzl function is affected by anesthetiss. Instraf, we have pursoed tnq fuhbtlonal anatomy of channel's contrigution uo anesthetic sensotivity. The", "random_deletion": "been implicated in susceptibility to bipolar disorder. our to confirm published report that a cation channel, we been unable to whether channel function is affected by Instead, we have pursued the functional anatomy of channel's contribution to anesthetic sensitivity.", "change_char_case": " been implicated in susceptibIlity to bipOlar dIsoRdeR. FRustRateD in our attempts TO conFirm a published report thAt the VeRTebrATe OrthoLog funcTIoNS As a NoN-sEleCtIVe CatioN chAnnel, we Have been unAblE tO ask whether cHAnNel functioN is Affected by anEstHetics. inSteAD, we haVe pUrsueD the fuNCtionaL anatomy oF cHAnnel's COntribuTIOn To anEsthetic sensitiviTY. THE", "whitespace_perturbation": " been implicated in suscep tibility t o bip ola r d is orde r. F rustrated in o u r at tempts to confirm a pu blish ed repo r tthatthe ver t eb r a teor th olo gf un ction s a s a non -selective  ca ti on channel,w ehave beenuna ble to ask w het her ch an nel funct ion  is a ffecte d  by an esthetics .I nstead ,  we hav e pu rsue d the functionala na t omy of channel 's con tr i bu t i ontoanesthetic  s ensit i vity. T h e", "underscore_trick": " been_implicated in_susceptibility to bipolar disorder._Frustrated in_our_attempts to_confirm_a published report_that the vertebrate_ortholog functions as a_non-selective cation channel,_we_have been unable to ask whether channel function is affected by anesthetics. Instead, we_have_pursued the_functional_anatomy_of channel's contribution to anesthetic_sensitivity. The"}
{"text": "45;phenotype described in our previous work. Starting from 3 wk of age, microarray analysis revealed upregulation of genes involved in DNA replication (Mcm6, Mcm7, Myc), DNA repair (Ddb2, Rad51l1) and translation (Eef1b2, Eef2, R", "synonym_substitution": "45;phenotype described in our previous work. Starting from 3 wk of old age, microarray psychoanalysis revealed upregulation of genes imply in DNA rejoinder (Mcm6, Mcm7, Myc), DNA repair (Ddb2, Rad51l1) and transformation (Eef1b2, Eef2, R", "butter_fingers": "45;phejotype described in our krevious work. Stattung frmm 3 wk of age, oicroarray analysis revealed upreguoation of genes involvdd in DNA replicarion (Ncm6, Mcm7, Myr), DNA reicir (Dsn2, Rad51n1) and translatipn (Eef1b2, Eex2, R", "random_deletion": "45;phenotype described in our previous work. Starting wk age, microarray revealed upregulation of (Mcm6, Myc), DNA repair Rad51l1) and translation Eef2, R", "change_char_case": "45;phenotype described in our prEvious work. startIng FroM 3 wK of aGe, miCroarray analysIS revEaled upregulation of genEs invOlVEd in dnA RepliCation (MCM6, MCM7, myc), dNa rEpaIr (dDb2, rad51l1) aNd tRanslatIon (Eef1b2, Eef2, r", "whitespace_perturbation": "45;phenotype described inour previo us wo rk.  St ar ting  fro m 3 wk of age, micr oarray analysis reveal ed up re g ulat i on  of g enes in v ol v e d i nDN A r ep l ic ation  (M cm6, Mc m7, Myc),DNA  r epair (Ddb2, Ra d51l1) and  tr anslation (E ef1 b2, Ee f2 , R ", "underscore_trick": "45;phenotype described_in our_previous work. Starting from_3 wk_of_age, microarray_analysis_revealed upregulation of_genes involved in_DNA replication (Mcm6, Mcm7,_Myc), DNA repair_(Ddb2,_Rad51l1) and translation (Eef1b2, Eef2, R"}
{"text": " de novo somatic mutations in an unbiased, genome-wide manner via high-throughput, whole-genome sequencing (WGS) of single-cell-derived HSPC clones. Importantly, to distinguish between naturally occurring spontaneous somatic mutation, potential cell culture-induced mutagenesis, and bona fide Cas9-mediated genetic alterations, the", "synonym_substitution": "de novo somatic mutations in an unbiased, genome - wide manner via eminent - throughput, solid - genome sequencing (WGS) of single - cell - derive HSPC clones. Importantly, to distinguish between naturally happen spontaneous somatic mutant, likely cell culture - induce mutagenesis, and bona fide Cas9 - mediated genetic alterations, the", "butter_fingers": " de novo somatic mutations ln an unbiased, ggnime-widx manned via hieh-throughput, whole-genome seqnencung (WTS) of single-cell-derivea HSPC cllnes. Impirtaitly, to distingumah betwczn nafmrallv iccurring sponjaneous somadic mutation, pmtdncial cell culture-induced mutagenesis, and boma fide Cas9-mediajed gtneeic zlterations, the", "random_deletion": "de novo somatic mutations in an unbiased, via whole-genome sequencing of single-cell-derived HSPC naturally spontaneous somatic mutation, cell culture-induced mutagenesis, bona fide Cas9-mediated genetic alterations, the", "change_char_case": " de novo somatic mutations in aN unbiased, gEnome-WidE maNnEr viA higH-throughput, whoLE-genOme sequencing (WGS) of singLe-celL-dERiveD hSpC cloNes. ImpoRTaNTLy, tO dIsTinGuISh BetweEn nAturallY occurring SpoNtAneous somatiC MuTation, poteNtiAl cell culturE-inDuced mUtAgeNEsis, aNd bOna fiDe Cas9-mEDiated Genetic alTeRAtions, THe", "whitespace_perturbation": " de novo somatic mutations  in an unb iased , g eno me -wid e ma nner via high- t hrou ghput, whole-genome se quenc in g  (WG S )of si ngle-ce l l- d e riv ed  H SPC  c l on es. I mpo rtantly , to disti ngu is h between na t ur ally occur rin g spontaneou s s omatic  m uta t ion,pot entia l cell cultur e-induced  m u tagene s is, and b on a fi de Cas9-mediatedg en e tic alteration s, the ", "underscore_trick": " de_novo somatic_mutations in an unbiased,_genome-wide manner_via_high-throughput, whole-genome_sequencing_(WGS) of single-cell-derived_HSPC clones. Importantly,_to distinguish between naturally_occurring spontaneous somatic_mutation,_potential cell culture-induced mutagenesis, and bona fide Cas9-mediated genetic alterations, the"}
{"text": " and FPR in monocytes, but not in PMNs, T cells or myelomonocytic cell lines. LPS treatment abolished polarized accumulation of F-actin and PIP3 in response to chemokine stimulation in monocytes but not in PMNs. TLR stimulation did not alter initial G-protein dependent signaling or the kinetics of endocytosis of", "synonym_substitution": "and FPR in monocytes, but not in PMNs, T cells or myelomonocytic cell occupation. LPS discussion abolished polarized accretion of F - actin and PIP3 in answer to chemokine stimulation in monocytes but not in PMNs. TLR foreplay did not alter initial G - protein dependent sign or the kinetics of endocytosis of", "butter_fingers": " anf FPR in monocytes, but nut in PMNs, T cells or kyelomknocytic cell lines. LPS treatment abllushed polarized accumulatiov of F-actpn and PIP3 in eesponse to chemoklue stjlulaciin in monocytex but not hn PMNs. TLR sthmjlction did not alter initial G-protein dependrnh signaling or the hinefpcw of endocytosis of", "random_deletion": "and FPR in monocytes, but not in cells myelomonocytic cell LPS treatment abolished PIP3 response to chemokine in monocytes but in PMNs. TLR stimulation did not initial G-protein dependent signaling or the kinetics of endocytosis of", "change_char_case": " and FPR in monocytes, but not in pMNs, T cells Or myeLomOnoCyTic cEll lInes. LPS treatmeNT aboLished polarized accumulAtion Of f-ActiN AnD PIP3 iN responSE tO CHemOkInE stImULaTion iN moNocytes But not in PMns. TlR Stimulation dID nOt alter iniTiaL G-protein depEndEnt sigNaLinG Or the KinEtics Of endoCYtosis Of", "whitespace_perturbation": " and FPR in monocytes, but  not in PM Ns, T  ce lls  o r my elom onocytic celll ines . LPS treatment abolis hed p ol a rize d  a ccumu lationo fF - act in  a ndPI P 3in re spo nse tochemokinesti mu lation in mo n oc ytes but n otin PMNs. TLR  st imulat io n d i d not  al ter i nitial G-prot ein depen de n t sign a ling or t he  kin etics of endocyto s is of", "underscore_trick": " and_FPR in_monocytes, but not in_PMNs, T_cells_or myelomonocytic_cell_lines. LPS treatment_abolished polarized accumulation_of F-actin and PIP3_in response to_chemokine_stimulation in monocytes but not in PMNs. TLR stimulation did not alter initial G-protein_dependent_signaling or_the_kinetics_of endocytosis of"}
{"text": " its dysfunction has been implicated in many neuropsychiatric disorders. We used a J-edited, single voxel-based spectroscopy method to measure GABA + macromolecules in the anterior cingulate cortex and right frontal white matter. In fact, our method allowed us to quantify metabolite differences between gray and white matter. Reproducibility of", "synonym_substitution": "its dysfunction has been implicated in many neuropsychiatric disorders. We used a J - edited, individual voxel - free-base spectroscopy method to measure GABA + macromolecules in the anterior cingulate lens cortex and right frontal white topic. In fact, our method allowed us to quantify metabolite differences between grey and white matter. Reproducibility of", "butter_fingers": " itd dysfunction has been ioplicated in maut neurmpsychjatric dksorders. We used a J-edited, smnglw voxtj-based spectroscoph method no measurw GAUA + macromoleculxa in thc antsvior eiigulate cortex snd right xrontal white kagtzr. In fact, our method allowed us to zuantifu letabolite difseremses gvtceen gray and white matter. Reprkducibinity of", "random_deletion": "its dysfunction has been implicated in many We a J-edited, voxel-based spectroscopy method in anterior cingulate cortex right frontal white In fact, our method allowed us quantify metabolite differences between gray and white matter. Reproducibility of", "change_char_case": " its dysfunction has been implIcated in maNy neuRopSycHiAtriC disOrders. We used a J-EDiteD, single voxel-based spectRoscoPy MEthoD To MeasuRe GABA + mACrOMOleCuLeS in ThE AnTerioR ciNgulate Cortex and rIghT fRontal white mATtEr. In fact, ouR meThod allowed uS to QuantiFy MetABolitE diFfereNces beTWeen grAy and whitE mATter. RePRoducibILItY of", "whitespace_perturbation": " its dysfunction has beenimplicated  in m any  ne ur opsy chia tric disorders .  Weused a J-edited, singl e vox el - base d  s pectr oscopym et h o d t ome asu re GA BA +mac romolec ules in th e a nt erior cingul a te  cortex an d r ight frontal  wh ite ma tt er. In fa ct,  ourmethod allowe d us to q ua n tify m e tabolit e di ffer ences between gra y  a n d white matter . Repr od u ci b i lit y o f", "underscore_trick": " its_dysfunction has_been implicated in many_neuropsychiatric disorders._We_used a_J-edited,_single voxel-based spectroscopy_method to measure_GABA + macromolecules in_the anterior cingulate_cortex_and right frontal white matter. In fact, our method allowed us to quantify metabolite_differences_between gray_and_white_matter. Reproducibility of"}
{"text": " candidate - PfRH5 - has been identified that elicits antibodies with very high levels of GIA activity. Binding of PfRH5 to the red cell protein basigin has been shown to be essential for merozoite invasion. We have tested antibodies to PfRH5 against parasites from different geographic locations and are evaluating", "synonym_substitution": "candidate - PfRH5 - has been identified that elicits antibodies with very high levels of GIA natural process. tie of PfRH5 to the red cellular telephone protein basigin has been shown to be substantive for merozoite invasion. We have tested antibodies to PfRH5 against parasite from different geographic locations and are measure", "butter_fingers": " cajdidate - PfRH5 - has been ldentified that glucits entibodjes with very high levels of GIA actmvitt. Bineing of PfRH5 to the rea cell prltein bawigii has been shown to be essentizp fox nerozoite invaxion. We haee tested antitoaizs to PfRH5 against parasites from disferent gfographic locajions wnd zge evaluating", "random_deletion": "candidate - PfRH5 - has been identified antibodies very high of GIA activity. red protein basigin has shown to be for merozoite invasion. We have tested to PfRH5 against parasites from different geographic locations and are evaluating", "change_char_case": " candidate - PfRH5 - has been identIfied that eLicitS anTibOdIes wIth vEry high levels oF gIA aCtivity. Binding of PfRH5 to The reD cELl prOTeIn basIgin has BEeN SHowN tO bE esSeNTiAl for MerOzoite iNvasion. We hAve TeSted antibodiES tO PfRH5 againSt pArasites from DifFerent GeOgrAPhic lOcaTions And are EValuatIng", "whitespace_perturbation": " candidate - PfRH5 - has b een identi fiedtha t e li cits  ant ibodies with v e ry h igh levels of GIA acti vity.  B i ndin g  o f PfR H5 to t h er e d c el lpro te i nbasig inhas bee n shown to  be  e ssential for me rozoite in vas ion. We have  te sted a nt ibo d ies t o P fRH5agains t  paras ites from  d i fferen t  geogra p h ic  loc ations and are ev a lu a ting", "underscore_trick": " candidate_- PfRH5_- has been identified_that elicits_antibodies_with very_high_levels of GIA_activity. Binding of_PfRH5 to the red_cell protein basigin_has_been shown to be essential for merozoite invasion. We have tested antibodies to PfRH5_against_parasites from_different_geographic_locations and are evaluating"}
{"text": " directly with the PPT. This observation led us to test whether the mutations in the RNase H of Tf1 were defective for the cleavages on either side of the PPT that generate the primer, or the cleavage that removes the PPT after it has primed plus strand synthesis. Defects in the", "synonym_substitution": "directly with the PPT. This observation led us to test whether the mutation in the RNase H of Tf1 were bad for the cleavages on either side of the PPT that render the flat coat, or the cleavage that removes the PPT after it has primed plus fibril deduction. Defects in the", "butter_fingers": " digectly with the PPT. This observation leb us to test shether ghe mutations in the RNase H od Tf1 qere defective for the cleavaged on eityer wude of the PPT thab gensvate chx primer, or the cleavage dhat removes tve P'T after it has primed plus strand srnthesix. Fefects in the", "random_deletion": "directly with the PPT. This observation led test the mutations the RNase H the on either side the PPT that the primer, or the cleavage that the PPT after it has primed plus strand synthesis. Defects in the", "change_char_case": " directly with the PPT. This obsErvation leD us to TesT whEtHer tHe muTations in the RNASe H oF Tf1 were defective for the CleavAgES on eIThEr sidE of the Ppt tHAT geNeRaTe tHe PRiMer, or The CleavagE that removEs tHe pPT after it haS PrImed plus stRanD synthesis. DeFecTs in thE", "whitespace_perturbation": " directly with the PPT. Th is observa tionled  us  t o te st w hether the mut a tion s in the RNase H of Tf 1 wer ed efec t iv e for  the cl e av a g eson  e ith er si de of  th e PPT t hat genera teth e primer, or th e cleavage  th at removes t hePPT af te r i t  haspri med p lus st r and sy nthesis.De f ects i n  the", "underscore_trick": " directly_with the_PPT. This observation led_us to_test_whether the_mutations_in the RNase_H of Tf1_were defective for the_cleavages on either_side_of the PPT that generate the primer, or the cleavage that removes the PPT_after_it has_primed_plus_strand synthesis. Defects in the"}
{"text": " of which changed in FA abundance in response to perturbation of myosinII activity, thus defining the myosinII-responsive FA proteome. FA abundance of 75% of proteins in the myosinII-responsive FA proteome were enhanced by contractility, including those involved in Rho-mediated FA maturation, stress fiber formation, and end", "synonym_substitution": "of which changed in FA abundance in response to perturbation of myosinII activity, therefore define the myosinII - responsive FA proteome. FA abundance of 75% of proteins in the myosinII - reactive FA proteome were enhanced by contractility, admit those involved in Rho - mediated FA growth, stress fiber constitution, and end", "butter_fingers": " of which changed in FA abukdance in response to pxrturbafion of oyosinII activity, thus definmng rhe mtosinII-responsive FA pfoteome. FW abundabce id 75% of protxjns in bke mykdinIN-rxsponsive FA prpteome wera enhanced by wovtxactility, including those involved ig Rho-meciwted FA maturajion, xeresa fiber formation, and end", "random_deletion": "of which changed in FA abundance in perturbation myosinII activity, defining the myosinII-responsive 75% proteins in the FA proteome were by contractility, including those involved in FA maturation, stress fiber formation, and end", "change_char_case": " of which changed in FA abundanCe in responSe to pErtUrbAtIon oF myoSinII activity, tHUs deFining the myosinII-respoNsive fA PRoteOMe. fA abuNdance oF 75% Of PROteInS iN thE mYOsInII-rEspOnsive Fa proteome wEre EnHanced by contRAcTility, inclUdiNg those involVed In Rho-mEdIatED FA maTurAtion, Stress FIber foRmation, anD eND", "whitespace_perturbation": " of which changed in FA ab undance in  resp ons e t opert urba tion of myosin I I ac tivity, thus definingthe m yo s inII - re spons ive FAp ro t e ome .FA  ab un d an ce of  75 % of pr oteins inthe  m yosinII-resp o ns ive FA pro teo me were enha nce d by c on tra c tilit y,inclu ding t h ose in volved in  R h o-medi a ted FAm a tu rati on, stress fiberf or m ation, and end ", "underscore_trick": " of_which changed_in FA abundance in_response to_perturbation_of myosinII_activity,_thus defining the_myosinII-responsive FA proteome._FA abundance of 75%_of proteins in_the_myosinII-responsive FA proteome were enhanced by contractility, including those involved in Rho-mediated FA maturation,_stress_fiber formation,_and_end"}
{"text": " one or more nonredundant roles in normal physiology. To gain additional insights into EpCAM function, we have generated mice with an EpCAM allele that can be conditionally deleted in a lineage-specific fashion. Working with Dr. Tessarollo and using recombineering, we developed a targeting vector that allowed l", "synonym_substitution": "one or more nonredundant roles in normal physiology. To gain additional insights into EpCAM affair, we have generate mice with an EpCAM allele that can be conditionally deleted in a lineage - specific manner. Working with Dr. Tessarollo and using recombineering, we developed a target vector that allow l", "butter_fingers": " onf or more nonredundant rules in normal khtsiolojy. To gzin addigional insights into EpCAM fnnctuon, wt have generated mize with aj EpCAM qlleow that can be condlcionampy dzlxted in a lineane-specific xashion. Workinc dich Dr. Tessarollo and using recombineqring, wr feveloped a tatgetimd vednov that allowed l", "random_deletion": "one or more nonredundant roles in normal gain insights into function, we have allele can be conditionally in a lineage-specific Working with Dr. Tessarollo and using we developed a targeting vector that allowed l", "change_char_case": " one or more nonredundant roleS in normal pHysioLogY. To GaIn adDitiOnal insights inTO EpCaM function, we have generaTed miCe WIth aN epcAM alLele thaT CaN BE coNdItIonAlLY dEleteD in A lineagE-specific fAshIoN. Working with dR. TEssarollo aNd uSing recombinEerIng, we dEvEloPEd a taRgeTing vEctor tHAt alloWed l", "whitespace_perturbation": " one or more nonredundantroles in n ormal  ph ysi ol ogy.  Togain additiona l  ins ights into EpCAM funct ion,we have ge nerat ed mice wi t h  an  E pC AMal l el e tha t c an be c onditional lyde leted in a l i ne age-specif icfashion. Wor kin g with  D r.T essar oll o and  using recomb ineering,  w e  devel o ped a t a r ge ting  vector that allo w ed l", "underscore_trick": " one_or more_nonredundant roles in normal_physiology. To_gain_additional insights_into_EpCAM function, we_have generated mice_with an EpCAM allele_that can be_conditionally_deleted in a lineage-specific fashion. Working with Dr. Tessarollo and using recombineering, we developed_a_targeting vector_that_allowed_l"}
{"text": "ional pretreatment skin biopsy samples to post treatment skin biopsies and normal control tissue. 2. We studied a chondrocyte primary cell lines from a bone lesions from one patients with NOMID and in collaboration with Dr. Stratakis laboratory, their group identified that the cyclic adenosine-monophosphate (cAMP) signaling pathway is", "synonym_substitution": "ional pretreatment skin biopsy samples to post treatment hide biopsy and normal control tissue. 2. We studied a chondrocyte basal cellular telephone lines from a bone lesions from one patients with NOMID and in collaboration with Dr. Stratakis lab, their group identified that the cyclic adenosine - monophosphate (cAMP) sign pathway is", "butter_fingers": "ionwl pretreatment skin bioksy samples to post treavment siin biopries and normal control tissne. 2. Qe stydied a chondrocyte prkmary celp lines drom q bone lesmkns from one lwtieutw with NOMID akd in collatoration with Gr. Scratakis laboratory, their group ideneified yhwt the cyclic wdenpfine-jonophosphate (cAMP) signaling pathwzy is", "random_deletion": "ional pretreatment skin biopsy samples to post biopsies normal control 2. We studied from bone lesions from patients with NOMID in collaboration with Dr. Stratakis laboratory, group identified that the cyclic adenosine-monophosphate (cAMP) signaling pathway is", "change_char_case": "ional pretreatment skin biopSy samples tO post TreAtmEnT skiN bioPsies and normal COntrOl tissue. 2. We studied a chonDrocyTe PRimaRY cEll liNes from A BoNE LesIoNs FroM oNE pAtienTs wIth NOMId and in collAboRaTion with Dr. StRAtAkis laboraTorY, their group iDenTified ThAt tHE cyclIc aDenosIne-monOPhosphAte (cAMP) siGnALing paTHway is", "whitespace_perturbation": "ional pretreatment skin bi opsy sampl es to  po sttr eatm entskin biopsiesa nd n ormal control tissue.2. We  s t udie d  a  chon drocyte pr i m ary  c el l l in e sfroma b one les ions fromone  p atients with NO MID and in  co llaborationwit h Dr.St rat a kis l abo rator y, the i r grou p identif ie d  thatt he cycl i c  a deno sine-monophosphat e  ( c AMP) signaling  pathw ay is ", "underscore_trick": "ional pretreatment_skin biopsy_samples to post treatment_skin biopsies_and_normal control_tissue._2. We studied_a chondrocyte primary_cell lines from a_bone lesions from_one_patients with NOMID and in collaboration with Dr. Stratakis laboratory, their group identified that_the_cyclic adenosine-monophosphate_(cAMP)_signaling_pathway is"}
{"text": " to unpolarized activation of Rap1. Identification of specific gene expression signatures characteristic of oncogenic pathways is an important step toward molecular classification of human malignancies. Aberrant activation of the Met signaling pathway is frequently associated with tumor progression and metastasis. We have defined the Met-regulated gene expression signature using global gene expression profiling of WT", "synonym_substitution": "to unpolarized activation of Rap1. Identification of specific gene expression signatures characteristic of oncogenic nerve pathway is an authoritative step toward molecular classification of human malignancies. Aberrant energizing of the Met signaling pathway is frequently associated with tumor progress and metastasis. We have defined the Met - regulated gene saying signature using ball-shaped gene expression profiling of WT", "butter_fingers": " to unpolarized activation uf Rap1. Identifieqtion mf spedific geve expression signatures chacactwristuc of oncogenic pathwahs is an pmportant stek toward moleculac classinncatikk of kunan malignancigs. Aberrant dctivation of dhd Let signaling pathway is frequently associstfd with tumor krogrtssyon znd metastasis. We have defined the Met-regllated gene exprexsion signature using globwl gfne expression proviling of WJ", "random_deletion": "to unpolarized activation of Rap1. Identification of expression characteristic of pathways is an of malignancies. Aberrant activation the Met signaling is frequently associated with tumor progression metastasis. We have defined the Met-regulated gene expression signature using global gene expression of WT", "change_char_case": " to unpolarized activation of rap1. IdentifIcatiOn oF spEcIfic Gene Expression signATureS characteristic of oncogEnic pAtHWays IS aN impoRtant stEP tOWArd MoLeCulAr CLaSsifiCatIon of huMan malignaNciEs. aberrant actiVAtIon of the MeT siGnaling pathwAy iS frequEnTly ASsociAteD with Tumor pROgressIon and metAsTAsis. We HAve defiNED tHe MeT-regulated gene expREsSIon signature usIng gloBaL GeNE ExpResSion profilInG of WT", "whitespace_perturbation": " to unpolarized activation  of Rap1.Ident ifi cat io n of  spe cific gene exp r essi on signatures characte risti co f on c og enicpathway s  i s anim po rta nt st ep to war d molec ular class ifi ca tion of huma n  m alignancie s.Aberrant act iva tion o fthe Met s ign aling  pathw a y is f requently  a s sociat e d witht u mo r pr ogression and met a st a sis. We have d efined  t h eM e t-r egu lated gene  e xpres s ion sig n at u r e  us i ng global gen e expressio n  pr ofilin gofW T", "underscore_trick": " to_unpolarized activation_of Rap1. Identification of_specific gene_expression_signatures characteristic_of_oncogenic pathways is_an important step_toward molecular classification of_human malignancies. Aberrant_activation_of the Met signaling pathway is frequently associated with tumor progression and metastasis. We_have_defined the_Met-regulated_gene_expression signature using global gene_expression profiling of WT"}
{"text": " terminals. Aim 2 We discovered that in endocrine cells vesicle material is captured on a dense network of pre-formed clathrin-coated structures following exocytosis. Despite the identification of many molecular components of clathrin-mediated endocytosis, a structural understanding of how these molecules come together to build and retrieve material from the", "synonym_substitution": "terminals. Aim 2 We discovered that in endocrine cell vesicle fabric is captured on a dense network of pre - form clathrin - coat structures following exocytosis. Despite the recognition of many molecular part of clathrin - mediated endocytosis, a structural understanding of how these molecules fall together to build and remember fabric from the", "butter_fingers": " tegminals. Aim 2 We discovertd that in endocrnbe celns vesjcle matdrial is captured on a dense nwtworj of pre-formed clathriv-coated snructures foloiwing exocbfosis. Dcfpits the mdentification pf many monecular componangs of clathrin-mediated endocytosis, a ftructutap understandind of row fhese molecules come together to bhild anv retrieve matetial from the", "random_deletion": "terminals. Aim 2 We discovered that in vesicle is captured a dense network exocytosis. the identification of molecular components of endocytosis, a structural understanding of how molecules come together to build and retrieve material from the", "change_char_case": " terminals. Aim 2 We discovered tHat in endocRine cEllS veSiCle mAterIal is captured oN A denSe network of pre-formed clAthriN-cOAted STrUcturEs folloWInG EXocYtOsIs. DEsPItE the iDenTificatIon of many mOleCuLar componentS Of Clathrin-meDiaTed endocytosIs, a StructUrAl uNDerstAndIng of How theSE molecUles come tOgETher to BUild and RETrIeve Material from the", "whitespace_perturbation": " terminals. Aim 2 We disco vered that  in e ndo cri ne  cel ls v esicle materia l  iscaptured on a dense ne twork  o f  pre - fo rmedclathri n -c o a ted  s tr uct ur e sfollo win g exocy tosis. Des pit ethe identifi c at ion of man y m olecular com pon ents o fcla t hrin- med iated  endoc y tosis,  a struct ur a l unde r standin g of  how  these moleculesc om e  together to b uild a nd re t r iev e m aterial fr om  the", "underscore_trick": " terminals._Aim 2_We discovered that in_endocrine cells_vesicle_material is_captured_on a dense_network of pre-formed_clathrin-coated structures following exocytosis._Despite the identification_of_many molecular components of clathrin-mediated endocytosis, a structural understanding of how these molecules come_together_to build_and_retrieve_material from the"}
{"text": " function in vivo, we identified a pre-existing targeted mouse embryonic stem cell generated by BayGenomics and, working with the CCR Mouse Knockout Core Facility headed by Dr. Lino Tessarollo, generated EpCAM +/- mice in which beta-galactosidase was inserted into one EpCAM allelle. EpCAM +/-", "synonym_substitution": "function in vivo, we identified a pre - existing targeted mouse embryonic shank cellular telephone generated by BayGenomics and, working with the CCR Mouse Knockout Core Facility lead by Dr. Lino Tessarollo, render EpCAM + /- mice in which beta - galactosidase was inserted into one EpCAM allelle. EpCAM + /-", "butter_fingers": " fujction in vivo, we identinied a pre-existiut targxted mohse embrhonic stem cell generated by BqyGenimics and, working with the CCR Louse Knickont Core Facility headed nv Dr. Mlno Tzswarollo, generajed EpCAM +/- mhce in which batx-gclactosidase was inserted into one E[CAM alkeple. EpCAM +/-", "random_deletion": "function in vivo, we identified a pre-existing embryonic cell generated BayGenomics and, working Core headed by Dr. Tessarollo, generated EpCAM mice in which beta-galactosidase was inserted one EpCAM allelle. EpCAM +/-", "change_char_case": " function in vivo, we identifieD a pre-existIng taRgeTed MoUse eMbryOnic stem cell geNEratEd by BayGenomics and, workIng wiTh THe CCr moUse KnOckout CORe fACilItY hEadEd BY DR. Lino tesSarollo, Generated EPCAm +/- mIce in which beTA-gAlactosidaSe wAs inserted inTo oNe EpCAm aLleLLe. EpCaM +/-", "whitespace_perturbation": " function in vivo, we iden tified a p re-ex ist ing  t arge tedmouse embryoni c  ste m cell generated by Ba yGeno mi c s an d ,worki ng with th e CCR  M ou seKn o ck out C ore  Facili ty headedbyDr . Lino Tessa r ol lo, genera ted  EpCAM +/- m ice  in wh ic h b e ta-ga lac tosid ase wa s  inser ted intoon e  EpCAM allelle . Ep CAM+/-", "underscore_trick": " function_in vivo,_we identified a pre-existing_targeted mouse_embryonic_stem cell_generated_by BayGenomics and,_working with the_CCR Mouse Knockout Core_Facility headed by_Dr._Lino Tessarollo, generated EpCAM +/- mice in which beta-galactosidase was inserted into one EpCAM_allelle._EpCAM +/-"}
{"text": " while it failed to block the synthesis of HBVADV-RA181T/N236T DNA, giving an IC50 value of 120,870. TDF quite well suppressed the synthesis of HBVWTCe, HBVETV-RL180M/S202G/M204V, and HBVADV", "synonym_substitution": "while it failed to block the synthesis of HBVADV - RA181T / N236 T DNA, giving an IC50 value of 120,870. TDF quite well inhibit the deduction of HBVWTCe, HBVETV - RL180M / S202G / M204V, and HBVADV", "butter_fingers": " whlle it failed to block tme synthesis of KVVADV-RE181T/N236T DNZ, giving an IC50 value of 120,870. TDF quite wxll wupprtfsed the synthesis of HBVWTBe, HBVETV-EL180M/S202J/M204V, and HBVADV", "random_deletion": "while it failed to block the synthesis DNA, an IC50 of 120,870. TDF of HBVETV-RL180M/S202G/M204V, and HBVADV", "change_char_case": " while it failed to block the syNthesis of HbVADV-rA181T/n236T DnA, GiviNg an iC50 value of 120,870. TDF quITe weLl suppressed the synthesIs of HbVwtCe, HbvEtV-RL180M/s202G/M204V, and hbVadv", "whitespace_perturbation": " while it failed to blockthe synthe sis o f H BVA DV -RA1 81T/ N236T DNA, giv i ng a n IC50 value of 120,87 0. TD Fq uite we ll su ppresse d  t h e  sy nt he sis  o f  H BVWTC e,HBVETV- RL180M/S20 2G/ M2 04V, and HBV A DV ", "underscore_trick": " while_it failed_to block the synthesis_of HBVADV-RA181T/N236T_DNA,_giving an_IC50_value of 120,870._TDF quite well_suppressed the synthesis of_HBVWTCe, HBVETV-RL180M/S202G/M204V, and_HBVADV"}
{"text": " presence of CMCP over 14 days, was subjected to real-time HBV-PCR as described in the Materials & Methods. Antiviral activity was scored as the percent inhibition relative to that of drug-unexposed control cells. As shown in Table 1, the activity of CMCP against HBVWT was significantly more potent than", "synonym_substitution": "presence of CMCP over 14 days, was subjected to real - meter HBV - PCR as trace in the Materials & Methods. Antiviral activity was scored as the percent prohibition relative to that of drug - unexposed control cells. As picture in Table 1, the activity of CMCP against HBVWT was significantly more potent than", "butter_fingers": " prfsence of CMCP over 14 dayr, was subjected to rean-time GBV-PCR ar described in the Materials & Nethoes. Antiviral activity das scoref as the perrent inhibition cslative to thzb of brng-unexposed conjrol cells. Av shown in Tabne 1, che activity of CMCP against HBVWT wws signoflcantly more pjtenu tran", "random_deletion": "presence of CMCP over 14 days, was real-time as described the Materials & as percent inhibition relative that of drug-unexposed cells. As shown in Table 1, activity of CMCP against HBVWT was significantly more potent than", "change_char_case": " presence of CMCP over 14 days, was Subjected tO real-TimE HBv-PcR as DescRibed in the MateRIals & methods. Antiviral activiTy was ScORed aS ThE percEnt inhiBItION reLaTiVe tO tHAt Of druG-unExposed Control celLs. AS sHown in Table 1, tHE aCtivity of CmCP Against HBVWT Was SignifIcAntLY more PotEnt thAn", "whitespace_perturbation": " presence of CMCP over 14days, wassubje cte d t oreal -tim e HBV-PCR as d e scri bed in the Materials &  Meth od s . An t iv iralactivit y  w a s  sc or ed  as  t h eperce ntinhibit ion relati veto  that of dru g -u nexposed c ont rol cells. A s s hown i nTab l e 1,the  acti vity o f  CMCPagainst H BV W T wass ignific a n tl y mo re potent than", "underscore_trick": " presence_of CMCP_over 14 days, was_subjected to_real-time_HBV-PCR as_described_in the Materials_& Methods. Antiviral_activity was scored as_the percent inhibition_relative_to that of drug-unexposed control cells. As shown in Table 1, the activity of_CMCP_against HBVWT_was_significantly_more potent than"}
{"text": " the RT, Ser85, Ala86, and Ala87. The triphosphate group interacts with a magnesium ion, which also interacts with Asp83 and Val84. These networks of strong polar interactions must be responsible for stabilizing the binding of CMCP-TP in the active site of RT of HBVWT. Both CMCP", "synonym_substitution": "the RT, Ser85, Ala86, and Ala87. The triphosphate group interacts with a magnesium ion, which also interacts with Asp83 and Val84. These networks of impregnable pivotal interactions must be responsible for stabilizing the ski binding of CMCP - TP in the active site of RT of HBVWT. Both CMCP", "butter_fingers": " thf RT, Ser85, Ala86, and Ala87. The triphosphate gtoyp intxracts sith a mxgnesium ion, which also intecactw wity Asp83 and Val84. These negworks of strong polac interactions mnat be rcfponalble yoc stabilizing tme binding mf CMCP-TP in tve aetive site of RT of HBVWT. Both CMCP", "random_deletion": "the RT, Ser85, Ala86, and Ala87. The interacts a magnesium which also interacts networks strong polar interactions be responsible for the binding of CMCP-TP in the site of RT of HBVWT. Both CMCP", "change_char_case": " the RT, Ser85, Ala86, and Ala87. The triphOsphate groUp intEraCts WiTh a mAgneSium ion, which alSO intEracts with Asp83 and Val84. TheSe netWoRKs of STrOng poLar inteRAcTIOns MuSt Be rEsPOnSible For StabiliZing the binDinG oF CMCP-TP in the ACtIve site of Rt of hBVWT. Both CMCp", "whitespace_perturbation": " the RT, Ser85, Ala86, and  Ala87. Th e tri pho sph at e gr oupinteracts with a ma gnesium ion, which als o int er a ctsw it h Asp 83 andV al 8 4 . T he se  ne tw o rk s ofstr ong pol ar interac tio ns  must be res p on sible forsta bilizing the  bi ndingof  CM C P-TPinthe a ctives ite of  RT of HB VW T . Both CMCP", "underscore_trick": " the_RT, Ser85,_Ala86, and Ala87. The_triphosphate group_interacts_with a_magnesium_ion, which also_interacts with Asp83_and Val84. These networks_of strong polar_interactions_must be responsible for stabilizing the binding of CMCP-TP in the active site of_RT_of HBVWT._Both_CMCP"}
{"text": " dealing with this class of FRET problems assumes that the rates of energy transfer (to single acceptors) sum linearly when multiple acceptors are present. Our preliminary data suggests that this treatment underestimates the true FRET efficiency. We have developed a new theory for dealing with these problems based on probability theory. We are currently", "synonym_substitution": "dealing with this class of FRET problems assumes that the pace of department of energy transfer (to single acceptor) union linearly when multiple acceptors are present. Our preliminary data indicate that this discussion underestimates the true FRET efficiency. We have developed a new theory for deal with these problems based on probability hypothesis. We are currently", "butter_fingers": " dewling with this class of FRET problems cwsumes that fhe rater of energy transfer (to singpe acceknors) sum linearly whev multiplv acceptoes ace present. Our pcsliminavv datz sugyewts that this jreatment ungerestimates tve txue FRET efficiency. We have developeq a new tjeory for dealyng eyth fhese problems based on probabilitg theorj. We are currentlu", "random_deletion": "dealing with this class of FRET problems the of energy (to single acceptors) are Our preliminary data that this treatment the true FRET efficiency. We have a new theory for dealing with these problems based on probability theory. We currently", "change_char_case": " dealing with this class of FREt problems aSsumeS thAt tHe RateS of eNergy transfer (tO SingLe acceptors) sum linearly When mUlTIple ACcEptorS are preSEnT. oUr pReLiMinArY DaTa sugGesTs that tHis treatmeNt uNdErestimates tHE tRue FRET effIciEncy. We have deVelOped a nEw TheORy for DeaLing wIth theSE problEms based oN pRObabilITy theorY. wE aRe cuRrently", "whitespace_perturbation": " dealing with this class o f FRET pro blems  as sum es  tha t th e rates of ene r gy t ransfer (to single acc eptor s) suml in early  when m u lt i p leac ce pto rs ar e pre sen t. Ourpreliminar y d at a suggests t h at  this trea tme nt underesti mat es the  t rue FRETeff icien cy. We have d evelopedan ew the o ry ford e al ingwith these proble m sb ased on probab ilityth e or y .  We  ar e currentl y", "underscore_trick": " dealing_with this_class of FRET problems_assumes that_the_rates of_energy_transfer (to single_acceptors) sum linearly_when multiple acceptors are_present. Our preliminary_data_suggests that this treatment underestimates the true FRET efficiency. We have developed a new_theory_for dealing_with_these_problems based on probability theory._We are currently"}
{"text": " system. We previously noted that when fly larvae are raised on food containing the oxidative agent bleomycin, very few are able to undergo metamorphosis to the pupal stage. In the past year we have shown that this phenotype is reversed by expression of TDP1 under the control of a nervous system-specific promoter.", "synonym_substitution": "system. We previously noted that when fly larvae are raised on food control the oxidative agentive role bleomycin, very few are able to undergo metamorphosis to the pupal stage. In the past class we have shown that this phenotype is revoke by expression of TDP1 under the command of a aflutter system - specific promoter.", "butter_fingers": " sydtem. We previously noted that when fly larvae ere raiaed on fuod containing the oxidative atent vleomycin, very few are able to lndergo mwtamiephosis to the pupal stafc. In chx past year we mave shown dhat this phenmthpz is reversed by expression of TDP1 ugder thr fontrol of a ngrvoux sysfvm-wpecific promoter.", "random_deletion": "system. We previously noted that when fly raised food containing oxidative agent bleomycin, undergo to the pupal In the past we have shown that this phenotype reversed by expression of TDP1 under the control of a nervous system-specific promoter.", "change_char_case": " system. We previously noted thAt when fly lArvae Are RaiSeD on fOod cOntaining the oxIDatiVe agent bleomycin, very feW are aBlE To unDErGo metAmorphoSIs TO The PuPaL stAgE. in The paSt yEar we haVe shown thaT thIs Phenotype is rEVeRsed by exprEssIon of TDP1 undeR thE contrOl Of a NErvouS syStem-sPecifiC PromotEr.", "whitespace_perturbation": " system. We previously not ed that wh en fl y l arv ae  are  rai sed on food co n tain ing the oxidative agen t ble om y cin, ve ry fe w are a b le t o u nd er gome t am orpho sis  to the  pupal sta ge.  I n the past y e ar  we have s how n that thisphe notype  i s r e verse d b y exp ressio n  of TD P1 underth e  contr o l of an e rv oussystem-specific p r om o ter.", "underscore_trick": " system._We previously_noted that when fly_larvae are_raised_on food_containing_the oxidative agent_bleomycin, very few_are able to undergo_metamorphosis to the_pupal_stage. In the past year we have shown that this phenotype is reversed by_expression_of TDP1_under_the_control of a nervous system-specific_promoter."}
{"text": " development of family level strategies to address this risk (NHGRI Protocol #07-HG-N140; PI: Laura Koehly). This research uses the CDC's Family Healthware to provide risk information based on participants family health history and behavioral recommendations based on participants current health behaviors. We used Family Healthware", "synonym_substitution": "development of family level strategies to cover this hazard (NHGRI Protocol # 07 - HG - N140; PI: Laura Koehly). This inquiry uses the CDC's Family Healthware to provide risk data based on participants family health history and behavioral recommendation based on participants current health behavior. We used Family Healthware", "butter_fingers": " degelopment of family leveu strategies to addresv this risk (NHERI Protocol #07-HG-N140; PI: Laura Koxhly). This research uses the CDC'r Family Jealthwaee ti provide rmak infoviatikk baszd on participanjs family hedlth history atd bzhavioral recommendations based on pwrticipsnhs current heajth nqhavjors. We used Family Healthware", "random_deletion": "development of family level strategies to address (NHGRI #07-HG-N140; PI: Koehly). This research to risk information based participants family health and behavioral recommendations based on participants health behaviors. We used Family Healthware", "change_char_case": " development of family level sTrategies tO addrEss ThiS rIsk (NhGRI protocol #07-HG-N140; PI: LAUra KOehly). This research uses tHe CDC'S FAMily hEaLthwaRe to proVIdE RIsk InFoRmaTiON bAsed oN paRticipaNts family hEalTh History and beHAvIoral recomMenDations based On pArticiPaNts CUrrenT heAlth bEhavioRS. We useD Family HeAlTHware", "whitespace_perturbation": " development of family lev el strateg ies t o a ddr es s th is r isk (NHGRI Pro t ocol  #07-HG-N140; PI: Laur a Koe hl y ). T h is  rese arch us e st h e C DC 's  Fa mi l yHealt hwa re to p rovide ris k i nf ormation bas e don partici pan ts family he alt h hist or y a n d beh avi oralrecomm e ndatio ns basedon partic i pants c u r re nt h ealth behaviors.W eu sed Family Hea lthwar e", "underscore_trick": " development_of family_level strategies to address_this risk_(NHGRI_Protocol #07-HG-N140;_PI:_Laura Koehly). This_research uses the_CDC's Family Healthware to_provide risk information_based_on participants family health history and behavioral recommendations based on participants current health behaviors._We_used Family_Healthware"}
{"text": " shown that both structural and signaling components of FA are crucial to translate mechanical cues into cell behavior, the molecular mechanism of mechanosensing remains unknown. Here we demonstrate that a molecular clutch, a mechanical link between the actin cytoskeleton and ECM-engaged integrins, acts as a mechanosensor in FAs, and the", "synonym_substitution": "shown that both structural and signaling components of FA are all-important to understand mechanical cue into cell demeanor, the molecular mechanism of mechanosensing remains obscure. Here we demonstrate that a molecular clasp, a mechanical link between the actin cytoskeleton and ECM - engaged integrins, dissemble as a mechanosensor in FAs, and the", "butter_fingers": " shlwn that both structural and signaling eimponeits of RA are cfucial to translate mechanicel cyes ibto cell behavior, the oolecular mechaniwm oh mechanosensing remains unknosk. Herz xe demonstrate jhat a molecglar clutch, a kezhcnical link between the actin cytoskqleton snf ECM-engaged igteggigs, adns as a mechanosensor in FAs, ans the", "random_deletion": "shown that both structural and signaling components are to translate cues into cell mechanosensing unknown. Here we that a molecular a mechanical link between the actin and ECM-engaged integrins, acts as a mechanosensor in FAs, and the", "change_char_case": " shown that both structural anD signaling CompoNenTs oF Fa are CrucIal to translate MEchaNical cues into cell behavIor, thE mOLecuLAr MechaNism of mEChANOseNsInG reMaINs UnknoWn. HEre we deMonstrate tHat A mOlecular clutCH, a Mechanical LinK between the aCtiN cytosKeLetON and EcM-eNgageD integRIns, actS as a mechaNoSEnsor iN fAs, and tHE", "whitespace_perturbation": " shown that both structura l and sign aling  co mpo ne ntsof F A are crucialt o tr anslate mechanical cue s int oc ellb eh avior , the m o le c u lar  m ec han is m  o f mec han osensin g remainsunk no wn. Here wed em onstrate t hat  a molecular  cl utch,amec h anica l l ink b etween the ac tin cytos ke l eton a n d ECM-e n g ag ed i ntegrins, acts as am echanosensor i n FAs,  a n dt h e", "underscore_trick": " shown_that both_structural and signaling components_of FA_are_crucial to_translate_mechanical cues into_cell behavior, the_molecular mechanism of mechanosensing_remains unknown. Here_we_demonstrate that a molecular clutch, a mechanical link between the actin cytoskeleton and ECM-engaged_integrins,_acts as_a_mechanosensor_in FAs, and the"}
{"text": " cells. To accomplish this, we developed a combination of high-throughput live cell imaging, super-resolution fluorescence imaging, and electron microscopy. Through this multi-modal imaging approach, the location, dynamics, and occupancy of individual proteins were mapped at specific populations of vesicles in cells and compared to the underlying cellular architecture that organ", "synonym_substitution": "cells. To accomplish this, we developed a combination of high - throughput hot cellular telephone imaging, super - resolution fluorescence imagination, and electron microscopy. Through this multi - modal imaging approach path, the location, moral force, and occupation of individual proteins were mapped at specific populations of vesicles in cells and compare to the underlying cellular architecture that organ", "butter_fingers": " cepls. To accomplish this, wt developed a comyunatioi of hifh-througfput live cell imaging, super-cesooutiob fluorescence imaging, and elecnron micriscoky. Through this mnmti-modal imagjkg ap'riach, the locatlon, dynamicv, and occupancf uf individual proteins were mapped at specifoc populations os vexyclea in cells and compared to the undsrlying cellular arcnitecture that organ", "random_deletion": "cells. To accomplish this, we developed a high-throughput cell imaging, fluorescence imaging, and imaging the location, dynamics, occupancy of individual were mapped at specific populations of in cells and compared to the underlying cellular architecture that organ", "change_char_case": " cells. To accomplish this, we deVeloped a coMbinaTioN of HiGh-thRougHput live cell imAGing, Super-resolution fluoresCence ImAGing, ANd ElectRon micrOScOPY. ThRoUgH thIs MUlTi-modAl iMaging aPproach, the LocAtIon, dynamics, aND oCcupancy of IndIvidual proteIns Were maPpEd aT SpeciFic PopulAtions OF vesicLes in cellS aND compaREd to the UNDeRlyiNg cellular architeCTuRE that organ", "whitespace_perturbation": " cells. To accomplish this , we devel opeda c omb in atio n of  high-throughp u t li ve cell imaging, super -reso lu t ionf lu oresc ence im a gi n g , a nd  e lec tr o nmicro sco py. Thr ough thismul ti -modal imagi n gapproach,the  location, d yna mics,an d o c cupan cyof in dividu a l prot eins were  m a pped a t  specif i c  p opul ations of vesicle s  i n  cells and com paredto th e und erl ying cellu la r arc h itectur e  t h a t  or g an", "underscore_trick": " cells._To accomplish_this, we developed a_combination of_high-throughput_live cell_imaging,_super-resolution fluorescence imaging,_and electron microscopy._Through this multi-modal imaging_approach, the location,_dynamics,_and occupancy of individual proteins were mapped at specific populations of vesicles in cells_and_compared to_the_underlying_cellular architecture that organ"}
{"text": " HBVETV-RL180M/S202G/M204V. While the methylidene group maintains some nonpolar interactions with the substituted Val204, the interaction with the substituted Met180 is completely lost for ETV-TP complexed with the RT of HBVETV-RL180M/S202", "synonym_substitution": "HBVETV - RL180M / S202G / M204V. While the methylidene group maintains some nonpolar interactions with the substituted Val204, the interaction with the substitute Met180 is wholly lost for ETV - TP complexed with the RT of HBVETV - RL180M / S202", "butter_fingers": " HBGETV-RL180M/S202G/M204V. While the meuhylidene group mcuntainv some nonpolaf interactions with the subsvitured Vql204, the interaction witf the subdtituted Met180 us completxmy lost for EFY-TP cmnplexed with tme RT of HBEETV-RL180M/S202", "random_deletion": "HBVETV-RL180M/S202G/M204V. While the methylidene group maintains some with substituted Val204, interaction with the for complexed with the of HBVETV-RL180M/S202", "change_char_case": " HBVETV-RL180M/S202G/M204V. While the methYlidene groUp maiNtaIns SoMe noNpolAr interactions WIth tHe substituted Val204, the intEractIoN With THe SubstItuted MET180 iS COmpLeTeLy lOsT FoR ETV-Tp coMplexed With the RT oF HBvEtV-RL180M/S202", "whitespace_perturbation": " HBVETV-RL180M/S202G/M204V . While th e met hyl ide ne  gro up m aintains somen onpo lar interactions withthe s ub s titu t ed  Val2 04, the in t e rac ti on  wi th th e sub sti tuted M et180 is c omp le tely lost fo r  E TV-TP comp lex ed with theRTof HBV ET V-R L 180M/ S20 2", "underscore_trick": " HBVETV-RL180M/S202G/M204V._While the_methylidene group maintains some_nonpolar interactions_with_the substituted_Val204,_the interaction with_the substituted Met180_is completely lost for_ETV-TP complexed with_the_RT of HBVETV-RL180M/S202"}
{"text": "V recombinants defines the limits and extent of intersubgroup recombination, and identifies specific sequence changes linked to pathogenesis and host interactions. Another ongoing study is in the process of characterizing a novel 8.0 kb endogenous retrovirus, XTERV-LS, that we identified in the amphibian, Xenopus tropicalis", "synonym_substitution": "V recombinants defines the limits and extent of intersubgroup recombination, and identify specific succession changes linked to pathogenesis and server interaction. Another ongoing study is in the process of characterize a fresh 8.0 kb endogenous retrovirus, XTERV - LS, that we identified in the amphibian, Xenopus tropicalis", "butter_fingers": "V rfcombinants defines the uimits and exteur of iitersubfroup rezombination, and identifies s'ecidic stzuence changes linyed to panhogenesiw anv host interactions. Anotmzr onfling wtudy is in thg process of characterizinc x uovel 8.0 kb endogenous retrovirus, XTERD-LS, thay ae identified yn tnq amlhibian, Xenopus tropicalis", "random_deletion": "V recombinants defines the limits and extent recombination, identifies specific changes linked to ongoing is in the of characterizing a 8.0 kb endogenous retrovirus, XTERV-LS, that identified in the amphibian, Xenopus tropicalis", "change_char_case": "V recombinants defines the liMits and extEnt of IntErsUbGrouP recOmbination, and iDEntiFies specific sequence chAnges LiNKed tO PaThogeNesis anD HoST IntErAcTioNs. aNoTher oNgoIng studY is in the prOceSs Of characteriZInG a novel 8.0 kb eNdoGenous retrovIruS, XTERV-lS, ThaT We ideNtiFied iN the amPHibian, xenopus trOpICalis", "whitespace_perturbation": "V recombinants defines the  limits an d ext ent  of  i nter subg roup recombina t ion,  and identifies specif ic se qu e ncec ha ngeslinkedt op a tho ge ne sis  a n dhostint eractio ns. Anothe r o ng oing study i s  i n the proc ess  of characte riz ing ano vel 8.0 k b e ndoge nous r e trovir us, XTERV -L S , that we iden t i fi ed i n the amphibian,X en o pus tropicalis ", "underscore_trick": "V recombinants_defines the_limits and extent of_intersubgroup recombination,_and_identifies specific_sequence_changes linked to_pathogenesis and host_interactions. Another ongoing study_is in the_process_of characterizing a novel 8.0 kb endogenous retrovirus, XTERV-LS, that we identified in the_amphibian,_Xenopus tropicalis"}
{"text": " dosing for more than one week, and compared the concentrations to those observed in 9 representative studies of background-exposed humans. Several recent animal studies have examined the effects of low-level PCBs (<0.05 mg/kg/d) in several species, with resulting tissue levels comparable to those in humans. If such", "synonym_substitution": "dosing for more than one week, and compared the concentrations to those note in 9 representative cogitation of background - expose homo. Several recent animal study have examined the effects of abject - level PCBs (< 0.05 mg / kg / d) in several coinage, with resulting tissue levels comparable to those in humans. If such", "butter_fingers": " doding for more than one wtek, and compared jhw concxntratikns to tfose observed in 9 representavive studues of background-exposdd humans. Several rectnt animal studies have ewcmines the xffects of low-lgvel PCBs (<0.05 mc/kg/d) in severan rpzcies, with resulting tissue levels cjmparabke to those in homans. Yf shbh", "random_deletion": "dosing for more than one week, and concentrations those observed 9 representative studies animal have examined the of low-level PCBs mg/kg/d) in several species, with resulting levels comparable to those in humans. If such", "change_char_case": " dosing for more than one week, aNd compared The coNceNtrAtIons To thOse observed in 9 rEPresEntative studies of backgRound-ExPOsed HUmAns. SeVeral reCEnT ANimAl StUdiEs HAvE examIneD the effEcts of low-lEveL PcBs (<0.05 mg/kg/d) in seVErAl species, wIth Resulting tisSue Levels CoMpaRAble tO thOse in Humans. iF such", "whitespace_perturbation": " dosing for more than oneweek, andcompa red  th econc entr ations to thos e  obs erved in 9 representat ive s tu d ieso fbackg round-e x po s e d h um an s.Se v er al re cen t anima l studieshav eexamined the ef fects of l ow- level PCBs ( <0. 05 mg/ kg /d) in se ver al sp ecies, with r esultingti s sue le v els com p a ra bleto those in human s .I f such", "underscore_trick": " dosing_for more_than one week, and_compared the_concentrations_to those_observed_in 9 representative_studies of background-exposed_humans. Several recent animal_studies have examined_the_effects of low-level PCBs (<0.05 mg/kg/d) in several species, with resulting tissue levels comparable_to_those in_humans._If_such"}
{"text": "2, Waterman CM1. Cell Biology and Physiology Center, NHLBI, NIH1;Department of Cell Biology, Lerner Research Institute NC-10, Cleveland Clinic.2 Cell migration requires coordinated assembly of focal adhesions and contraction in the actomyosin cytoskeleton. The small GTPase Rac1 is critical to", "synonym_substitution": "2, Waterman CM1. Cell Biology and Physiology Center, NHLBI, NIH1;Department of Cell Biology, Lerner Research Institute NC-10, Cleveland Clinic.2 Cell migration requires coordinated assembly of focal adhesions and contraction in the actomyosin cytoskeleton. The humble GTPase Rac1 is critical to", "butter_fingers": "2, Waherman CM1. Cell Biology akd Physiology Ceurer, NHNBI, NIG1;Departmdnt of Cell Biology, Lerner Rxseaech Ibstitute NC-10, Cleveland Zlinic.2 Cepl migrarion eequires coordinatcb assslbly if focal adheslons and cottraction in tve aetomyosin cytoskeleton. The small GTPwse Rac1 id critical to", "random_deletion": "2, Waterman CM1. Cell Biology and Physiology NIH1;Department Cell Biology, Research Institute NC-10, coordinated of focal adhesions contraction in the cytoskeleton. The small GTPase Rac1 is to", "change_char_case": "2, Waterman CM1. Cell Biology and PHysiology CEnter, nHLbI, NiH1;depaRtmeNt of Cell BiologY, lernEr Research Institute NC-10, CLevelAnD clinIC.2 CEll miGration REqUIRes CoOrDinAtED aSsembLy oF focal aDhesions anD coNtRaction in the ACtOmyosin cytOskEleton. The smaLl GtPase RAc1 Is cRIticaL to", "whitespace_perturbation": "2, Waterman CM1. Cell Biol ogy and Ph ysiol ogy  Ce nt er,NHLB I, NIH1;Depart m entof Cell Biology, Lerne r Res ea r ch I n st itute  NC-10, Cl e v ela nd  C lin ic . 2Cellmig rationrequires c oor di nated assemb l yof focal a dhe sions and co ntr action  i n t h e act omy osincytosk e leton.  The smal lG TPaseR ac1 isc r it ical  to", "underscore_trick": "2, Waterman_CM1. Cell_Biology and Physiology Center,_NHLBI, NIH1;Department_of_Cell Biology,_Lerner_Research Institute NC-10,_Cleveland Clinic.2 Cell_migration requires coordinated assembly_of focal adhesions_and_contraction in the actomyosin cytoskeleton. The small GTPase Rac1 is critical to"}
{"text": " closing out a pilot study of 5 patients with adult-onset Still's disease (AOSD) who were treated with the long acting IL-1 inhibitor rilonacept. We are assessing long term efficacy and safety. However, 3 patients had a satisfactory response to IL-1 TRAP and continue to be on", "synonym_substitution": "closing out a pilot study of 5 patients with adult - attack Still's disease (AOSD) who were treat with the long acting IL-1 inhibitor rilonacept. We are tax farseeing term efficacy and safety. However, 3 affected role have a satisfactory response to IL-1 TRAP and proceed to be on", "butter_fingers": " cllsing out a pilot study uf 5 patients wijh adult-mnset Atill's dksease (AOSD) who were treated wuth tye long acting IL-1 inhicitor rillnacept. Qe ace assessing lonj term enyicacg and wafety. However, 3 patients had a satisfawturv response to IL-1 TRAP and continue tj be on", "random_deletion": "closing out a pilot study of 5 adult-onset disease (AOSD) were treated with rilonacept. are assessing long efficacy and safety. 3 patients had a satisfactory response IL-1 TRAP and continue to be on", "change_char_case": " closing out a pilot study of 5 paTients with Adult-OnsEt STiLl's dIseaSe (AOSD) who were tREateD with the long acting IL-1 inHibitOr RIlonACePt. We aRe assesSInG LOng TeRm EffIcACy And saFetY. HoweveR, 3 patients hAd a SaTisfactory reSPoNse to IL-1 TRAp anD continue to bE on", "whitespace_perturbation": " closing out a pilot study  of 5 pati entswit h a du lt-o nset  Still's disea s e (A OSD) who were treatedwithth e  lon g  a cting  IL-1 i n hi b i tor  r il ona ce p t.  We a reassessi ng long te rmef ficacy and s a fe ty. Howeve r,3 patients h ada sati sf act o ry re spo nse t o IL-1 TRAP a nd contin ue to beo n", "underscore_trick": " closing_out a_pilot study of 5_patients with_adult-onset_Still's disease_(AOSD)_who were treated_with the long_acting IL-1 inhibitor rilonacept._We are assessing_long_term efficacy and safety. However, 3 patients had a satisfactory response to IL-1 TRAP_and_continue to_be_on"}
{"text": " a combination of data from original investigators, laboratory reanalyses, calculations based on published data, and expert opinion. The mainstay of our comparison was the median level of PCB 153 in maternal pregnancy serum. We found that a) the distribution of PCB exposure in the majority of studies overlapped substantially, b) exposure levels in the", "synonym_substitution": "a combination of data from original investigators, laboratory reanalyses, calculations free-base on publish data, and expert opinion. The mainstay of our comparison was the medial level of PCB 153 in maternal pregnancy serum. We found that a) the distribution of PCB vulnerability in the majority of studies overlapped well, b) vulnerability levels in the", "butter_fingers": " a fombination of data from original invesjitators, laborztory rexnalyses, calculations based ln publushed data, and expert upinion. Tje mainsray id our compedison was the ledicn level of PCB 153 in materndl pregnancy sarjm. We found that a) the distribution os PCB ecplsure in the mwjorptr of studies overlapped substantially, g) exposlre levels in the", "random_deletion": "a combination of data from original investigators, calculations on published and expert opinion. was median level of 153 in maternal serum. We found that a) the of PCB exposure in the majority of studies overlapped substantially, b) exposure levels the", "change_char_case": " a combination of data from oriGinal invesTigatOrs, LabOrAtorY reaNalyses, calculaTIons Based on published data, anD expeRt OPiniON. THe maiNstay of OUr COMpaRiSoN waS tHE mEdian LevEl of PCB 153 In maternal PreGnAncy serum. We fOUnD that a) the dIstRibution of PCb exPosure In The MAjoriTy oF studIes oveRLapped SubstantiAlLY, b) expoSUre leveLS In The", "whitespace_perturbation": " a combination of data fro m original  inve sti gat or s, l abor atory reanalys e s, c alculations based on p ublis he d  dat a ,and e xpert o p in i o n.Th emai ns t ay  of o urcompari son was th e m ed ian level of PC B 153 in m ate rnal pregnan cyserum.  W e f o und t hat  a) t he dis t ributi on of PCB  e x posure in them a jo rity  of studies overl a pp e d substantiall y, b)ex p os u r e l eve ls in the", "underscore_trick": " a_combination of_data from original investigators,_laboratory reanalyses,_calculations_based on_published_data, and expert_opinion. The mainstay_of our comparison was_the median level_of_PCB 153 in maternal pregnancy serum. We found that a) the distribution of PCB_exposure_in the_majority_of_studies overlapped substantially, b) exposure_levels in the"}
{"text": " on body composition. We are currently intensively studying a variant MC3R that is associated with adiposity in children and which appears to have functional significance for MC3R signal transduction (1). Children who are homozygous for two rare polymorphisms (Thr6Lys and Val81Ile) have significantly greater fat mass", "synonym_substitution": "on body composition. We are currently intensively studying a variant MC3R that is consociate with adiposity in child and which appears to have functional meaning for MC3R signal transduction (1). Children who are homozygous for two rare polymorphisms (Thr6Lys and Val81Ile) have importantly bang-up fat batch", "butter_fingers": " on body composition. We are currently inteuwively studyjng a vafiant MC3R that is associated wuth aeiposity in children avd which wppears ro heve functional smfnificakee fod MC3R wignal transdugtion (1). Chilgren who are hmmuzvgous for two rare polymorphisms (Thr6Jys and Vwl81Ile) have siggifibagtly greater fat mass", "random_deletion": "on body composition. We are currently intensively variant that is with adiposity in have significance for MC3R transduction (1). Children are homozygous for two rare polymorphisms and Val81Ile) have significantly greater fat mass", "change_char_case": " on body composition. We are curRently inteNsiveLy sTudYiNg a vAriaNt MC3R that is assOCiatEd with adiposity in childRen anD wHIch aPPeArs to Have funCTiONAl sIgNiFicAnCE fOr MC3R SigNal tranSduction (1). ChIldReN who are homozYGoUs for two raRe pOlymorphisms (thr6lys and vaL81IlE) Have sIgnIficaNtly grEAter faT mass", "whitespace_perturbation": " on body composition. We a re current ly in ten siv el y st udyi ng a variant M C 3R t hat is associated with  adip os i ty i n  c hildr en andw hi c h  ap pe ar s t oh av e fun cti onal si gnificance  fo rMC3R signalt ra nsduction(1) . Children w hoare ho mo zyg o us fo r t wo ra re pol y morphi sms (Thr6 Ly s  and V a l81Ile) h av e si gnificantly great e rf at mass", "underscore_trick": " on_body composition._We are currently intensively_studying a_variant_MC3R that_is_associated with adiposity_in children and_which appears to have_functional significance for_MC3R_signal transduction (1). Children who are homozygous for two rare polymorphisms (Thr6Lys and Val81Ile)_have_significantly greater_fat_mass"}
{"text": " function, and abnormal physiological states associated with human maladies. Furthermore, the delivery of membrane protein complexes to cell surface micro-domains must involve the coordination of exocytotic and endocytotic reactions. Lesions in exocytosis have been tied to some forms of muscular dystrophy, and may also be involved in alcohol induced", "synonym_substitution": "function, and abnormal physiological states associated with human malady. Furthermore, the rescue of membrane protein complexes to cell surface micro - domains must involve the coordination of exocytotic and endocytotic reaction. Lesions in exocytosis have been tied to some phase of brawny dystrophy, and may besides be imply in alcohol induced", "butter_fingers": " fujction, and abnormal physlological states associeted wifh human maladies. Furthermore, the depicery if membrane protein cooplexes tl cell syrfare micro-domains must involve tgc cooxdmnation of exocitotic and etdocytotic reawtkous. Lesions in exocytosis have been tyed to xole forms of mufculsw dyanriphy, and may also be involved in alcmhol induced", "random_deletion": "function, and abnormal physiological states associated with Furthermore, delivery of protein complexes to the of exocytotic and reactions. Lesions in have been tied to some forms muscular dystrophy, and may also be involved in alcohol induced", "change_char_case": " function, and abnormal physioLogical staTes asSocIatEd With HumaN maladies. FurthERmorE, the delivery of membrane ProteIn COmplEXeS to ceLl surfaCE mICRo-dOmAiNs mUsT InVolve The CoordinAtion of exoCytOtIc and endocytOTiC reactions. lesIons in exocytOsiS have bEeN tiED to soMe fOrms oF muscuLAr dystRophy, and mAy ALso be iNVolved iN ALcOhol Induced", "whitespace_perturbation": " function, and abnormal ph ysiologica l sta tes  as so ciat ed w ith human mala d ies.  Furthermore, the deli veryof memb r an e pro tein co m pl e x esto  c ell  s u rf ace m icr o-domai ns must in vol ve  the coordin a ti on of exoc yto tic and endo cyt otic r ea cti o ns. L esi ons i n exoc y tosishave been  t i ed tos ome for m s  o f mu scular dystrophy, an d  may also be i nvolve di na l coh olinduced", "underscore_trick": " function,_and abnormal_physiological states associated with_human maladies._Furthermore,_the delivery_of_membrane protein complexes_to cell surface_micro-domains must involve the_coordination of exocytotic_and_endocytotic reactions. Lesions in exocytosis have been tied to some forms of muscular dystrophy,_and_may also_be_involved_in alcohol induced"}
{"text": " genes related to mitochondrial function. Using the information we have gained from studying CA2, we also aim to determine the nature of the developmental down-regulation of synaptic plasticity in the form of critical periods and how plasticity is modulated in different brain areas. Recently, we have found that a specialized extracellular matrix, called perineur", "synonym_substitution": "genes related to mitochondrial function. Using the data we have gain from studying CA2, we besides aim to decide the nature of the developmental down - regulation of synaptic malleability in the shape of critical periods and how malleability is regulate in different genius areas. Recently, we have found that a specialized extracellular matrix, call perineur", "butter_fingers": " gejes related to mitochondvial function. Usnbg the inforjation wd have gained from studying RA2, ww alsi aim to determine the nature ov the decelokmental down-regulefion of synapflc plcsvicity in the fprm of cridical periods dna kow plasticity is modulated in diffewent brsij areas. Recentjy, wt hwve round that a specialized extracellhlar maurix, called perineir", "random_deletion": "genes related to mitochondrial function. Using the have from studying we also aim the down-regulation of synaptic in the form critical periods and how plasticity is in different brain areas. Recently, we have found that a specialized extracellular matrix, perineur", "change_char_case": " genes related to mitochondriAl function. using The InfOrMatiOn we Have gained from STudyIng CA2, we also aim to determIne thE nATure OF tHe devElopmenTAl DOWn-rEgUlAtiOn OF sYnaptIc pLasticiTy in the forM of CrItical periodS AnD how plastiCitY is modulated In dIffereNt BraIN areaS. ReCentlY, we havE Found tHat a speciAlIZed extRAcellulAR MaTrix, Called perineur", "whitespace_perturbation": " genes related to mitochon drial func tion.  Us ing  t he i nfor mation we have gain ed from studying CA2,we al so aimt odeter mine th e  n a t ure  o fthe  d e ve lopme nta l down- regulation  of  s ynaptic plas t ic ity in the  fo rm of critic alperiod sand how p las ticit y is m o dulate d in diff er e nt bra i n areas . Re cent ly, we have found th a t a specialize d extr ac e ll u l armat rix, calle dperin e ur", "underscore_trick": " genes_related to_mitochondrial function. Using the_information we_have_gained from_studying_CA2, we also_aim to determine_the nature of the_developmental down-regulation of_synaptic_plasticity in the form of critical periods and how plasticity is modulated in different_brain_areas. Recently,_we_have_found that a specialized extracellular_matrix, called perineur"}
{"text": " of IGD, which is now being investigated in our genetic study (below) to determine whether there is a common molecular cause for these phenotypes. We have also initiated a pilot study to determine the prevalence of psychiatric disorders and symptoms of negative emotional states in our cohort, compared with healthy controls, in order to determine whether there", "synonym_substitution": "of IGD, which is now being investigated in our genetic study (downstairs) to settle whether there is a common molecular cause for these phenotype. We have also initiated a pilot cogitation to determine the prevalence of psychiatric disorder and symptoms of negative aroused states in our cohort, compared with healthy restraint, in order to determine whether there", "butter_fingers": " of IGD, which is now being lnvestigated in our genxtic sthdy (belod) to determine whether there iw a cimmon molecular cause wor these phenotypes. Xe have also inivjated a pilot dtudv vo determine thg prevalence of psychiatriw aidorders and symptoms of negative emjtional shates in our cjhoru, cjmpadvd with healthy controls, in ordsr to dttermine whether tnere", "random_deletion": "of IGD, which is now being investigated genetic (below) to whether there is these We have also a pilot study determine the prevalence of psychiatric disorders symptoms of negative emotional states in our cohort, compared with healthy controls, in to determine whether there", "change_char_case": " of IGD, which is now being invesTigated in oUr genEtiC stUdY (belOw) to Determine whethER theRe is a common molecular caUse foR tHEse pHEnOtypeS. We have ALsO INitIaTeD a pIlOT sTudy tO deTermine The prevaleNce Of Psychiatric dISoRders and syMptOms of negativE emOtionaL sTatES in ouR coHort, cOmpareD With heAlthy contRoLS, in ordER to deteRMInE wheTher there", "whitespace_perturbation": " of IGD, which is now bein g investig atedinour  g enet ic s tudy (below) t o  det ermine whether there i s a c om m on m o le cular  causef or t hes eph eno ty p es . Wehav e alsoinitiateda p il ot study tod et ermine the  pr evalence ofpsy chiatr ic  di s order s a nd sy mptoms of neg ative emo ti o nal st a tes ino u rcoho rt, compared with he a lthy controls,  in or de r  t o det erm ine whethe rthere ", "underscore_trick": " of_IGD, which_is now being investigated_in our_genetic_study (below)_to_determine whether there_is a common_molecular cause for these_phenotypes. We have_also_initiated a pilot study to determine the prevalence of psychiatric disorders and symptoms of_negative_emotional states_in_our_cohort, compared with healthy controls,_in order to determine whether_there"}
{"text": " cations are ubiquitous in the biological milieu, yet existing theories do not adequately explain their effect on and interactions with charged macromolecules. Moreover, experiments to study these interactions are difficult to perform, particularly in solution, because above a low ion concentration threshold multivalent cations generally cause phase separation or precipitation of charged macromolecules. Since macroscopic", "synonym_substitution": "cations are ubiquitous in the biological milieu, yet existing theories do not adequately excuse their consequence on and interactions with charged macromolecule. Moreover, experiment to study these interaction are difficult to perform, peculiarly in solution, because above a depleted ion concentration brink multivalent cations generally induce phase separation or precipitation of charge macromolecules. Since macroscopic", "butter_fingers": " cahions are ubiquitous in uhe biological milieu, yev existjng theofies do not adequately explamn tyeir tyfect on and interacgions witj chargee marromolecules. Morxkver, exizrimehbs to wtudy these injeractions ase difficult tm oexform, particularly in solution, becaufe abovr w low ion concgntrauiog thdvsmold multivalent cations generalmy caust phase separation or precipitation of chargfd mwcromolecules. Sincf macroscopuc", "random_deletion": "cations are ubiquitous in the biological milieu, theories not adequately their effect on Moreover, to study these are difficult to particularly in solution, because above a ion concentration threshold multivalent cations generally cause phase separation or precipitation of charged Since macroscopic", "change_char_case": " cations are ubiquitous in the Biological MilieU, yeT exIsTing TheoRies do not adequATely Explain their effect on anD inteRaCTionS WiTh chaRged macROmOLEcuLeS. MOreOvER, eXperiMenTs to stuDy these intEraCtIons are diffiCUlT to perform, ParTicularly in sOluTion, beCaUse ABove a Low Ion coNcentrATion thReshold muLtIValent CAtions gENErAlly Cause phase separatIOn OR precipitation Of charGeD MaCROmoLecUles. Since mAcRoscoPIc", "whitespace_perturbation": " cations are ubiquitous in  the biolo gical  mi lie u,  yet  exi sting theories do n ot adequately explaintheir  e f fect on  andinterac t io n s  wi th  c har ge d  m acrom ole cules.Moreover,exp er iments to st u dy  these int era ctions are d iff icultto  pe r form,  pa rticu larlyi n solu tion, bec au s e abov e  a lowi o nconc entration thresho l dm ultivalent cat ions g en e ra l l y c aus e phase se pa ratio n  or pre c ip i t a tio n  of charged m acromolecul e s.Sincema cro s copic", "underscore_trick": " cations_are ubiquitous_in the biological milieu,_yet existing_theories_do not_adequately_explain their effect_on and interactions_with charged macromolecules. Moreover,_experiments to study_these_interactions are difficult to perform, particularly in solution, because above a low ion concentration_threshold_multivalent cations_generally_cause_phase separation or precipitation of_charged macromolecules. Since macroscopic"}
{"text": " the clinical development of a molecular targeted agent from Phase 0 trials directly into combination Phase 1 studies with best available therapies in five CTEP-sponsored trials. The molecular data from the validated assay justified bypassing any single agent Phase I or II trials, where it was not expected to show any single agent activity in most genetic", "synonym_substitution": "the clinical development of a molecular targeted agent from Phase 0 trials immediately into combination Phase 1 cogitation with best available therapy in five CTEP - sponsored trial. The molecular data from the validate assay absolve bypassing any individual agent Phase I or II trials, where it was not expect to show any single agentive role activity in most genetic", "butter_fingers": " thf clinical development on a molecular tatgwted ajent frkm Phase 0 trials directly into combiiatiin Phqse 1 studies with best availablv therapiws ii five CTEP-sponsored trials. Ths molzcnlar data from jhe validateg assay justifhea yypassing any single agent Phase I ow II troaps, where it waf nou evpecfvd to show any single agent actjvity ii most genetic", "random_deletion": "the clinical development of a molecular targeted Phase trials directly combination Phase 1 in CTEP-sponsored trials. The data from the assay justified bypassing any single agent I or II trials, where it was not expected to show any single activity in most genetic", "change_char_case": " the clinical development of a Molecular tArgetEd aGenT fRom PHase 0 Trials directly INto cOmbination Phase 1 studies With bEsT AvaiLAbLe theRapies iN FiVE cTEp-sPoNsoReD TrIals. THe mOleculaR data from tHe vAlIdated assay jUStIfied bypasSinG any single agEnt phase I Or iI tRIals, wHerE it waS not exPEcted tO show any sInGLe agenT ActivitY IN mOst gEnetic", "whitespace_perturbation": " the clinical developmentof a molec ulartar get ed  age nt f rom Phase 0 tr i alsdirectly into combinat ion P ha s e 1s tu dieswith be s ta v ail ab le  th er a pi es in  fi ve CTEP -sponsored  tr ia ls. The mole c ul ar data fr omthe validate d a ssay j us tif i ed by pas singany si n gle ag ent Phase  I or IIt rials,w h er e it  was not expected to show any singl e agen ta ct i v ity  in  most gene ti c", "underscore_trick": " the_clinical development_of a molecular targeted_agent from_Phase_0 trials_directly_into combination Phase_1 studies with_best available therapies in_five CTEP-sponsored trials._The_molecular data from the validated assay justified bypassing any single agent Phase I or_II_trials, where_it_was_not expected to show any_single agent activity in most_genetic"}
{"text": " several developmental biologists with relevant expertise. One question that we are addressing relates to the functional equivalence of EpCAM and TROP2, an EpCAM-related molecule that is also expressed in epithelial tissues. The approach that we are taking involves use of transgenic mice that express EpCAM or TROP2 in intestinal epithelium and", "synonym_substitution": "several developmental biologists with relevant expertise. One question that we are address relates to the running equivalence of EpCAM and TROP2, an EpCAM - related atom that is also express in epithelial tissues. The access that we are taking involves use of transgenic mouse that express EpCAM or TROP2 in intestinal epithelium and", "butter_fingers": " segeral developmental biolugists with relgvqnt ex'ertise. One quertion that we are addressing rwlatew to the functional eqjivalence of EpCAN anv TROP2, an EpCAM-rxmated moleculs thac ms also expressgd in epithenial tissues. Tve a'proach that we are taking involves tse of yrwnsgenic mice jhat txpwess VpGAM or TROP2 in intestinal epithemium anv", "random_deletion": "several developmental biologists with relevant expertise. One we addressing relates the functional equivalence EpCAM-related that is also in epithelial tissues. approach that we are taking involves of transgenic mice that express EpCAM or TROP2 in intestinal epithelium and", "change_char_case": " several developmental bioloGists with rElevaNt eXpeRtIse. ONe quEstion that we arE AddrEssing relates to the funcTionaL eQUivaLEnCe of EPCAM and trOp2, AN EpcAm-rElaTeD MoLeculE thAt is alsO expressed In ePiThelial tissuES. THe approach ThaT we are taking InvOlves uSe Of tRAnsgeNic Mice tHat expREss EpCaM or TROP2 iN iNTestinAL epitheLIUm And", "whitespace_perturbation": " several developmental bio logists wi th re lev ant  e xper tise . One question that  we are addressing rel atesto thef un ction al equi v al e n ceof  E pCA Ma nd  TROP 2,an EpCA M-relatedmol ec ule that isa ls o expresse d i n epithelial  ti ssues.  T hea pproa chthatwe are taking  involves  u s e of t r ansgeni c mi ce t hat express EpCAM or TROP2 in intes tinalep i th e l ium  an d", "underscore_trick": " several_developmental biologists_with relevant expertise. One_question that_we_are addressing_relates_to the functional_equivalence of EpCAM_and TROP2, an EpCAM-related_molecule that is_also_expressed in epithelial tissues. The approach that we are taking involves use of transgenic_mice_that express_EpCAM_or_TROP2 in intestinal epithelium and"}
{"text": " also anticipated value in being able to evaluate the effects of molecular targeted therapy on markers of chemotherapeutic sensitivity and resistance to guide the selection of which chemotherapeutic regimens are suitable for combination with the molecular therapy, and which should be avoided in combination because, for example, the molecular targeted therapy induces high expression of a known molecular determinant", "synonym_substitution": "also anticipated value in being able to evaluate the effects of molecular targeted therapy on marker of chemotherapeutic sensitivity and underground to guide the selection of which chemotherapeutic regimens are desirable for combination with the molecular therapy, and which should be avoided in combination because, for example, the molecular targeted therapy induces eminent expression of a known molecular antigenic determinant", "butter_fingers": " aldo anticipated value in neing able to evcouate vhe effscts of oolecular targeted therapy oi maekers of chemotherapeutic sdnsitivitj and resustaice to guide the selection of smich ehxmotherapeutic tegimens are suitable for woobnnation with the molecular therapy, agd whicn dhould be avoiqed pn comgpnction because, for example, the mkleculag targeted therapu induces high expression lf a known molecular dfterminant", "random_deletion": "also anticipated value in being able to effects molecular targeted on markers of guide selection of which regimens are suitable combination with the molecular therapy, and should be avoided in combination because, for example, the molecular targeted therapy induces expression of a known molecular determinant", "change_char_case": " also anticipated value in beiNg able to evAluatE thE efFeCts oF molEcular targeted THeraPy on markers of chemotherApeutIc SEnsiTIvIty anD resistANcE TO guIdE tHe sElECtIon of WhiCh chemoTherapeutiC reGiMens are suitaBLe For combinaTioN with the moleCulAr therApY, anD Which ShoUld be AvoideD In combInation beCaUSe, for eXAmple, thE MOlEculAr targeted therapy INdUCes high expressIon of a KnOWn MOLecUlaR determinaNt", "whitespace_perturbation": " also anticipated value in  being abl e toeva lua te  the  eff ects of molecu l ar t argeted therapy on mar kersof chem o th erape utic se n si t i vit yan d r es i st ancetoguide t he selecti onof  which chemo t he rapeutic r egi mens are sui tab le for  c omb i natio n w ith t he mol e culartherapy,an d  which shouldb e  a void ed in combination be c ause, for exam ple, t he mo l e cul artargeted t he rapyi nducesh ig h e xpr e ssion of a kn own molecul a r d etermi na nt", "underscore_trick": " also_anticipated value_in being able to_evaluate the_effects_of molecular_targeted_therapy on markers_of chemotherapeutic sensitivity_and resistance to guide_the selection of_which_chemotherapeutic regimens are suitable for combination with the molecular therapy, and which should be_avoided_in combination_because,_for_example, the molecular targeted therapy_induces high expression of a_known molecular_determinant"}
{"text": " hyaluronic acid solutions in the presence of monovalent and divalent counterions. We studied the collective diffusion processes in these solutions by dynamic light scattering and determined the osmotic modulus from the relaxation response. We determined the distribution of counterions around charged biopolymer molecules using anomalous small-angle X-ray", "synonym_substitution": "hyaluronic acid solutions in the presence of monovalent and divalent counterions. We studied the corporate dissemination processes in these solutions by active light scatter and determined the osmotic modulus from the relaxation reaction. We determined the distribution of counterions around charged biopolymer molecule using anomalous small - slant X - ray", "butter_fingers": " hywluronic acid solutions ln the presence of monotalent znd divauent counterions. We studied vhe xollextive diffusion procesres in thvse solutuons vy dynamic light sgctterjkg anb vetermined the psmotic mogulus from the rdlcxation response. We determined the dystribuyiln of counterijns swouns charged biopolymer molecules usihg anomelous small-anglr X-ray", "random_deletion": "hyaluronic acid solutions in the presence of divalent We studied collective diffusion processes light and determined the modulus from the response. We determined the distribution of around charged biopolymer molecules using anomalous small-angle X-ray", "change_char_case": " hyaluronic acid solutions in The presencE of moNovAleNt And dIvalEnt counterions. wE stuDied the collective diffuSion pRoCEsseS In These SolutioNS bY DYnaMiC lIghT sCAtTerinG anD determIned the osmOtiC mOdulus from thE ReLaxation reSpoNse. We determiNed The disTrIbuTIon of CouNteriOns aroUNd charGed biopolYmER molecULes usinG ANoMaloUs small-angle X-ray", "whitespace_perturbation": " hyaluronic acid solutions  in the pr esenc e o f m on oval entand divalent c o unte rions. We studied thecolle ct i ve d i ff usion  proces s es i n t he se  so lu t io ns by  dy namic l ight scatt eri ng  and determi n ed  the osmot icmodulus from  th e rela xa tio n  resp ons e. We  deter m ined t he distri bu t ion of counter i o ns  aro und charged biopo l ym e r molecules us ing an om a lo u s  sm all -angle X-r ay ", "underscore_trick": " hyaluronic_acid solutions_in the presence of_monovalent and_divalent_counterions. We_studied_the collective diffusion_processes in these_solutions by dynamic light_scattering and determined_the_osmotic modulus from the relaxation response. We determined the distribution of counterions around charged_biopolymer_molecules using_anomalous_small-angle_X-ray"}
{"text": " exactly. Maximum numbers of clinical PD assays could be developed by the SAIC-Frederick PD program by using a strategy of tiered technical support services, in which a small number of highly qualified vendors are selected for some particular assays, but also manage a larger number of second tier vendors to develop assays with which they", "synonym_substitution": "exactly. Maximum numbers of clinical PD assay could be modernize by the SAIC - Frederick PD program by using a strategy of tiered technical accompaniment services, in which a small issue of highly restricted vendors are selected for some particular assays, but besides manage a larger number of second tier seller to develop assays with which they", "butter_fingers": " exwctly. Maximum numbers of clinical PD assays conld be sevelopea by the SAIC-Frederick PD prlgeam bt using a strategy of giered tebhnical syppoct services, in wijch a small nhlber if highly quallfied vendoss are selecteg wox some particular assays, but also magage a kagger number of secpgd tjvr vendors to develop assays wifh whici they", "random_deletion": "exactly. Maximum numbers of clinical PD assays developed the SAIC-Frederick program by using support in which a number of highly vendors are selected for some particular but also manage a larger number of second tier vendors to develop assays which they", "change_char_case": " exactly. Maximum numbers of clInical PD asSays cOulD be DeVeloPed bY the SAIC-FrederICk PD Program by using a strategY of tiErED tecHNiCal suPport seRViCES, in WhIcH a sMaLL nUmber Of hIghly quAlified venDorS aRe selected foR SoMe particulAr aSsays, but also ManAge a laRgEr nUMber oF seCond tIer venDOrs to dEvelop assAyS With whICh they", "whitespace_perturbation": " exactly. Maximum numbersof clinica l PDass ays  c ould  bedeveloped by t h e SA IC-Frederick PD progra m byus i ng a st rateg y of ti e re d tec hn ic alsu p po rt se rvi ces, in  which a s mal lnumber of hi g hl y qualifie d v endors are s ele cted f or  so m e par tic ularassays ,  but a lso manag ea  large r  number o fseco nd tier vendors t o  d e velop assays w ith wh ic h  t h e y", "underscore_trick": " exactly._Maximum numbers_of clinical PD assays_could be_developed_by the_SAIC-Frederick_PD program by_using a strategy_of tiered technical support_services, in which_a_small number of highly qualified vendors are selected for some particular assays, but also_manage_a larger_number_of_second tier vendors to develop_assays with which they"}
{"text": " presently focusing on CFCP, another nucleoside reverse transcriptase inhibitor, which is more potent against HBV than CMCP. Retroviruses exist as infectious viruses and as endogenous retroviral copies (ERVs) which are viral DNA copies integrated into host DNA. Such ERVs are a permanent part of the host genome and represent", "synonym_substitution": "presently focusing on CFCP, another nucleoside reverse transcriptase inhibitor, which is more potent against HBV than CMCP. Retroviruses exist as infectious virus and as endogenous retroviral copy (ERVs) which are viral DNA copies integrated into host DNA. Such ERVs are a permanent function of the host genome and represent", "butter_fingers": " prfsently focusing on CFCP, another nucleoside reterse tdanscripgase inhibitor, which is more pitent against HBV than CMCP. Retrovirlses exisr as unfectious viruses and aa endmjenous retrovirsl copies (ARVs) which are vkrcl DNA copies integrated into host DGA. Such EGVs are a permwnenu pwrt kf the host genome and represent", "random_deletion": "presently focusing on CFCP, another nucleoside reverse which more potent HBV than CMCP. and endogenous retroviral copies which are viral copies integrated into host DNA. Such are a permanent part of the host genome and represent", "change_char_case": " presently focusing on CFCP, anOther nucleOside RevErsE tRansCripTase inhibitor, wHIch iS more potent against HBV tHan CMcP. rEtroVIrUses eXist as iNFeCTIouS vIrUseS aND aS endoGenOus retrOviral copiEs (ErVS) which are virAL DnA copies inTegRated into hosT DNa. Such ErVS arE A permAneNt parT of the HOst genOme and repReSEnt", "whitespace_perturbation": " presently focusing on CFC P, another  nucl eos ide  r ever se t ranscriptase i n hibi tor, which is more pot ent a ga i nstH BV  than  CMCP.R et r o vir us es  ex is t  a s inf ect ious vi ruses andasen dogenous ret r ov iral copie s ( ERVs) whichare  viral  D NAc opies  in tegra ted in t o host  DNA. Suc hE RVs ar e  a perm a n en t pa rt of the host ge n om e  and represent ", "underscore_trick": " presently_focusing on_CFCP, another nucleoside reverse_transcriptase inhibitor,_which_is more_potent_against HBV than_CMCP. Retroviruses exist_as infectious viruses and_as endogenous retroviral_copies_(ERVs) which are viral DNA copies integrated into host DNA. Such ERVs are a_permanent_part of_the_host_genome and represent"}
{"text": "G mice. Approximately 12% of colonies and similar percentages of human cells at 5 months after transplantation demonstrated copGFP expression. Integration junction-specific PCR analysis of gDNA derived from GFP+ colonies and post-transplant human CD45+ cells confirmed that reporter gene expression was attributable to integrated donor template sequences, as opposed to", "synonym_substitution": "G mice. Approximately 12% of colonies and similar percentage of human cell at 5 months after transplantation demonstrated copGFP formulation. Integration junction - specific PCR psychoanalysis of gDNA derived from GFP+ colonies and post - transplant human CD45 + cells confirm that reporter gene expression was attributable to integrated donor template succession, as opposed to", "butter_fingers": "G mlce. Approximately 12% of couonies and similar perrentagea of humxn cells at 5 months after trenspoantaupon demonstrated copGWP expresdion. Intwgrauion junction-specmric PCR analyals of jDNA derived frpm GFP+ colmnies and post-drxndplant human CD45+ cells confirmed thae reporyeg gene expressyon ews afnrlbutable to integrated donor temllate stquences, as opposec to", "random_deletion": "G mice. Approximately 12% of colonies and of cells at months after transplantation PCR of gDNA derived GFP+ colonies and human CD45+ cells confirmed that reporter expression was attributable to integrated donor template sequences, as opposed to", "change_char_case": "G mice. Approximately 12% of colonIes and simiLar peRceNtaGeS of hUman Cells at 5 months aFTer tRansplantation demonstrAted cOpgfP exPReSsion. integraTIoN JUncTiOn-SpeCiFIc pCR anAlySis of gDnA derived fRom gFp+ colonies and POsT-transplanT huMan CD45+ cells coNfiRmed thAt RepORter gEne ExpreSsion wAS attriButable to InTEgrateD Donor teMPLaTe seQuences, as opposed tO", "whitespace_perturbation": "G mice. Approximately 12%of colonie s and  si mil ar  per cent ages of humanc ells  at 5 months after tra nspla nt a tion de monst rated c o pG F P  ex pr es sio n. In tegra tio n junct ion-specif icPC R analysis o f  g DNA derive d f rom GFP+ col oni es and  p ost - trans pla nt hu man CD 4 5+ cel ls confir me d  thatr eporter g en e ex pression was attr i bu t able to integr ated d on o rt e mpl ate  sequences ,as op p osed to ", "underscore_trick": "G mice._Approximately 12%_of colonies and similar_percentages of_human_cells at_5_months after transplantation_demonstrated copGFP expression._Integration junction-specific PCR analysis_of gDNA derived_from_GFP+ colonies and post-transplant human CD45+ cells confirmed that reporter gene expression was attributable_to_integrated donor_template_sequences,_as opposed to"}
{"text": "1 cells. Because downregulatory mechanims are induced in chronic helminth infection, we have attempted to study the spillover effect of the downregulation on responses and diseases that are non-parasitic. To this end, we have both clinical trials underway and in vitro models that have demonstrated the influence of pre-", "synonym_substitution": "1 cells. Because downregulatory mechanims are induced in chronic helminth infection, we have attempted to analyze the spillover consequence of the downregulation on responses and diseases that are non - parasitic. To this conclusion, we have both clinical trials afoot and in vitro models that have demonstrated the influence of pre-", "butter_fingers": "1 cepls. Because downregulatovy mechanims are inducev in chdonic heuminth infection, we have attxmptwd to study the spillover ewfect of nhe downrwguletion on responsxa and dlfeassd thct are non-parasijic. To this and, we have bodh cpinical trials underway and in vitrj modelx hhat have demogstrseed fhe influence of pre-", "random_deletion": "1 cells. Because downregulatory mechanims are induced helminth we have to study the on and diseases that non-parasitic. To this we have both clinical trials underway in vitro models that have demonstrated the influence of pre-", "change_char_case": "1 cells. Because downregulatorY mechanims Are inDucEd iN cHronIc heLminth infectioN, We haVe attempted to study the sPilloVeR EffeCT oF the dOwnreguLAtION on ReSpOnsEs ANd DiseaSes That are Non-parasitIc. TO tHis end, we have BOtH clinical tRiaLs underway anD in Vitro mOdEls THat haVe dEmonsTrated THe inflUence of prE-", "whitespace_perturbation": "1 cells. Because downregul atory mech anims  ar e i nd uced  inchronic helmin t h in fection, we have attem ptedto stud y  t he sp illover ef f e ctof  t hedo w nr egula tio n on re sponses an d d is eases that a r enon-parasi tic . To this en d,we hav ebot h  clin ica l tri als un d erwayand in vi tr o  model s  that h a v edemo nstrated the infl u en c e of pre-", "underscore_trick": "1 cells._Because downregulatory_mechanims are induced in_chronic helminth_infection,_we have_attempted_to study the_spillover effect of_the downregulation on responses_and diseases that_are_non-parasitic. To this end, we have both clinical trials underway and in vitro models_that_have demonstrated_the_influence_of pre-"}
{"text": "-polar amino acids, multiple lines of negative evidence suggest that ARTS-1 does not possess TNFR1 sheddase activity. These findings indicate that ARTS-1 is a multi-functional ectoprotein capable of associating with and promoting the release of soluble TNFR1. Since release of soluble TNFR1", "synonym_substitution": "-polar amino acids, multiple lines of negative evidence suggest that ARTS-1 does not own TNFR1 sheddase natural process. These findings indicate that ARTS-1 is a multi - running ectoprotein capable of consort with and promoting the acquittance of soluble TNFR1. Since release of soluble TNFR1", "butter_fingers": "-polwr amino acids, multiple uines of negatirw evidxnce sufgest thxt ARTS-1 does not possess TNFC1 shwddast activity. These fivdings inficate tyat ERTS-1 is a multi-fnhctional ectolvoteiu rapable of assogiating witv and promotinc ghz release of soluble TNFR1. Since relewse of xopuble TNFR1", "random_deletion": "-polar amino acids, multiple lines of negative that does not TNFR1 sheddase activity. is multi-functional ectoprotein capable associating with and the release of soluble TNFR1. Since of soluble TNFR1", "change_char_case": "-polar amino acids, multiple liNes of negatIve evIdeNce SuGgesT thaT ARTS-1 does not poSSess tNFR1 sheddase activity. ThEse fiNdINgs iNDiCate tHat ARTS-1 IS a MULti-FuNcTioNaL EcToproTeiN capablE of associaTinG wIth and promotINg The release Of sOluble TNFR1. SiNce ReleasE oF soLUble TnFR1", "whitespace_perturbation": "-polar amino acids, multip le lines o f neg ati veev iden ce s uggest that AR T S-1does not possess TNFR1  shed da s e ac t iv ity.These f i nd i n gsin di cat et ha t ART S-1  is a m ulti-funct ion al  ectoprotein ca pable of a sso ciating with  an d prom ot ing the r ele ase o f solu b le TNF R1. Since  r e leaseo f solub l e  T NFR1 ", "underscore_trick": "-polar amino_acids, multiple_lines of negative evidence_suggest that_ARTS-1_does not_possess_TNFR1 sheddase activity._These findings indicate_that ARTS-1 is a_multi-functional ectoprotein capable_of_associating with and promoting the release of soluble TNFR1. Since release of soluble TNFR1"}
{"text": "II shedding. Reciprocal co-immunoprecipitation experiments identified that membrane-associated ARTS-1 associates with the soluble, cleaved forms of IL-6R and IL-1RII. Further, ARTS-1 promoted IL-6R and IL-1RII shedding, as demonstrated by a direct", "synonym_substitution": "II shedding. Reciprocal co - immunoprecipitation experiments identified that membrane - consociate ARTS-1 associate with the soluble, cleaved forms of IL-6R and IL-1RII. Further, ARTS-1 promoted IL-6R and IL-1RII spill, as demonstrated by a direct", "butter_fingers": "II dhedding. Reciprocal co-imounoprecipitation expeciments identifked that membrane-associated ERTS-1 assoxiates with the solubld, cleaved forms od IL-6C and IL-1RII. Furtisr, ARTS-1 promofcd IL-6X end IL-1RII sheddlng, as demotstrated by a gifeet", "random_deletion": "II shedding. Reciprocal co-immunoprecipitation experiments identified that associates the soluble, forms of IL-6R IL-6R IL-1RII shedding, as by a direct", "change_char_case": "II shedding. Reciprocal co-immUnoprecipiTatioN exPerImEnts IdenTified that membRAne-aSsociated ARTS-1 associateS with ThE SoluBLe, CleavEd forms OF Il-6r And iL-1rIi. FuRtHEr, aRTS-1 pRomOted IL-6R And IL-1RII shEddInG, as demonstraTEd By a direct", "whitespace_perturbation": "II shedding. Reciprocal co -immunopre cipit ati onex peri ment s identified t h at m embrane-associated ART S-1 a ss o ciat e swiththe sol u bl e ,  cl ea ve d f or m sof IL -6R  and IL -1RII. Fur the r,  ARTS-1 prom o te d IL-6R an d I L-1RII shedd ing , as d em ons t rated  by  a di rect", "underscore_trick": "II shedding._Reciprocal co-immunoprecipitation_experiments identified that membrane-associated_ARTS-1 associates_with_the soluble,_cleaved_forms of IL-6R_and IL-1RII. Further,_ARTS-1 promoted IL-6R and_IL-1RII shedding, as_demonstrated_by a direct"}
{"text": " degree of positive symptoms expressed by schizophrenics. Strong effects on anesthesia sensitivity are caused by mutations in the narrow abdomen (na) gene of Drosophila. We earlier showed that the na gene encodes a putative ion channel, one that is expressed broadly in the central nervous system of all metazoans and one whose human ortholog has", "synonym_substitution": "degree of positive symptoms expressed by schizophrenic. impregnable effects on anesthesia sensitivity are caused by mutation in the minute abdomen (na) gene of Drosophila. We earlier showed that the sodium gene encodes a putative ion channel, one that is expressed broadly in the central anxious system of all metazoans and one whose human ortholog suffer", "butter_fingers": " dehree of positive symptomr expressed by schizopirenics. Strong dffects on anesthesia sensitmvitt are caused by mutations iv the nargow abdomwn (ne) gene of Drosopijla. We ccrlied shocev that the na ggne encodes d putative ion cfaunel, one that is expressed broadly ig the crnhral nervous sistem jf aml metazoans and one whose human odtholog has", "random_deletion": "degree of positive symptoms expressed by schizophrenics. on sensitivity are by mutations in of We earlier showed the na gene a putative ion channel, one that expressed broadly in the central nervous system of all metazoans and one whose ortholog has", "change_char_case": " degree of positive symptoms eXpressed by SchizOphRenIcS. StrOng eFfects on anesthESia sEnsitivity are caused by mUtatiOnS In thE NaRrow aBdomen (nA) GeNE Of DRoSoPhiLa. wE eArlieR shOwed thaT the na gene EncOdEs a putative iON cHannel, one tHat Is expressed bRoaDly in tHe CenTRal neRvoUs sysTem of aLL metazOans and onE wHOse humAN ortholOG HaS", "whitespace_perturbation": " degree of positive sympto ms express ed by  sc hiz op hren ics.  Strong effect s  onanesthesia sensitivity  areca u sedb ymutat ions in th e nar ro wabd om e n(na)gen e of Dr osophila.Weea rlier showed th at the nagen e encodes aput ativeio n c h annel , o ne th at ise xpress ed broadl yi n thec entraln e rv oussystem of all met a zo a ns and one who se hum an or t h olo g h as", "underscore_trick": " degree_of positive_symptoms expressed by schizophrenics._Strong effects_on_anesthesia sensitivity_are_caused by mutations_in the narrow_abdomen (na) gene of_Drosophila. We earlier_showed_that the na gene encodes a putative ion channel, one that is expressed broadly_in_the central_nervous_system_of all metazoans and one_whose human ortholog has"}
{"text": "OMID using the long acting IL-1 inhibitor canakinumab with the goal of finding an optimal dose regimen and monitoring long term outcome is currently ongoing. LABORATORY: 1. We have characterized the inflammatory skin lesions in collaboration with Dr. Lowes at Rockefeller by comparing lesional and nonles", "synonym_substitution": "OMID using the long acting IL-1 inhibitor canakinumab with the goal of find an optimum dose regimen and monitoring retentive terminus outcome is currently ongoing. LABORATORY: 1. We have characterize the incendiary skin lesions in collaboration with Dr. Lowes at Rockefeller by comparing lesional and nonles", "butter_fingers": "OMIF using the long acting LL-1 inhibitor cancjinumau with fhe goal of finding an optimal dose ceginen abd monitoring long tero outcome is currwntlb ongoing. LABORAVKRY: 1. We have dmaraccecized the inflakmatory skhn lesions in woulcboration with Dr. Lowes at Rockefellqr by cpmoaring lesionaj anc nonmvs", "random_deletion": "OMID using the long acting IL-1 inhibitor the of finding optimal dose regimen is ongoing. LABORATORY: 1. have characterized the skin lesions in collaboration with Dr. at Rockefeller by comparing lesional and nonles", "change_char_case": "OMID using the long acting IL-1 iNhibitor caNakinUmaB wiTh The gOal oF finding an optiMAl doSe regimen and monitoring Long tErM OutcOMe Is curRently oNGoING. LAbOrAtORy: 1. WE HaVe chaRacTerized The inflammAtoRy Skin lesions iN CoLlaboratioN wiTh Dr. Lowes at ROckEfelleR bY coMParinG leSionaL and noNLes", "whitespace_perturbation": "OMID using the long acting  IL-1 inhi bitor  ca nak in umab  wit h the goal off indi ng an optimal dose reg imenan d  mon i to ringlong te r mo u tco me  i s c ur r en tly o ngo ing. LA BORATORY:1.We  have charac t er ized the i nfl ammatory ski n l esions  i n c o llabo rat ion w ith Dr .  Lowes  at Rocke fe l ler by compari n g  l esio nal and nonles", "underscore_trick": "OMID using_the long_acting IL-1 inhibitor canakinumab_with the_goal_of finding_an_optimal dose regimen_and monitoring long_term outcome is currently_ongoing. LABORATORY: 1._We_have characterized the inflammatory skin lesions in collaboration with Dr. Lowes at Rockefeller by_comparing_lesional and_nonles"}
{"text": " complexes of CMCP-TP and ETV-TP with the RT of HBVETV-RL180M/S202G/M204V, it is most likely that the difference in the interactions of CMCP-TP over ETV-TP with the RT of HBVETV-RL180M/S", "synonym_substitution": "complexes of CMCP - TP and ETV - TP with the RT of HBVETV - RL180M / S202G / M204V, it is most likely that the difference in the interaction of CMCP - TP over ETV - TP with the RT of HBVETV - RL180M / S", "butter_fingers": " colplexes of CMCP-TP and ETY-TP with the RT of HBVEVV-RL180M/S202G/J204V, it is most likely that the differxnce in tye interactions of CMCO-TP over VTV-TP wity tht RT of HBVETV-RL180M/S", "random_deletion": "complexes of CMCP-TP and ETV-TP with the HBVETV-RL180M/S202G/M204V, is most that the difference over with the RT HBVETV-RL180M/S", "change_char_case": " complexes of CMCP-TP and ETV-TP With the RT oF HBVEtV-Rl180M/S202g/M204v, it iS mosT likely that the DIffeRence in the interactions Of CMCp-Tp Over etV-tP witH the RT oF hBvetV-Rl180M/s", "whitespace_perturbation": " complexes of CMCP-TP andETV-TP wit h the  RT  of  H BVET V-RL 180M/S202G/M20 4 V, i t is most likely thatthe d if f eren c ein th e inter a ct i o nsof  C MCP -T P  o ver E TV- TP with  the RT of  HB VE TV-RL180M/S", "underscore_trick": " complexes_of CMCP-TP_and ETV-TP with the_RT of_HBVETV-RL180M/S202G/M204V,_it is_most_likely that the_difference in the_interactions of CMCP-TP over_ETV-TP with the_RT_of HBVETV-RL180M/S"}
{"text": " position these cleavages would alter the sequences at the 3' end of the minus strand and as a result have a drastic impact on the ability of IN to catalyze strand transfer. The sequence from the 3? ends of the minus strand cDNA from Tf1 particles was determined using ligation mediated PCR. The mutations clearly", "synonym_substitution": "position these cleavages would alter the sequences at the 3' goal of the minus strand and as a resultant role have a drastic impact on the ability of IN to catalyze strand transmit. The sequence from the 3? ends of the subtraction strand cDNA from Tf1 particles was determined using ligation intercede PCR. The mutations clearly", "butter_fingers": " podition these cleavages wuuld alter the sequencxs at tge 3' end uf the minus strand and as a rwsult have a drastic impact on the ahility od IN ro catalyzx strand transrcr. Thz wequence from jhe 3? ends of the minus strdna eDNA from Tf1 particles was determineq using llgation mediatgd PCG. Ehe jltctions clearly", "random_deletion": "position these cleavages would alter the sequences 3' of the strand and as impact the ability of to catalyze strand The sequence from the 3? ends the minus strand cDNA from Tf1 particles was determined using ligation mediated PCR. mutations clearly", "change_char_case": " position these cleavages wouLd alter the SequeNceS at ThE 3' end Of thE minus strand anD As a rEsult have a drastic impacT on thE aBIlitY Of iN to cAtalyze STrAND trAnSfEr. THe SEqUence FroM the 3? endS of the minuS stRaNd cDNA from Tf1 PArTicles was dEteRmined using lIgaTion meDiAteD pCR. ThE muTatioNs cleaRLy", "whitespace_perturbation": " position these cleavageswould alte r the  se que nc es a t th e 3' end of th e  min us strand and as a res ult h av e  a d r as tic i mpact o n  t h e  ab il it y o fI Nto ca tal yze str and transf er.  T he sequencef ro m the 3? e nds  of the minu s s trandcD NAf rom T f1parti cles w a s dete rmined us in g  ligat i on medi a t ed  PCR . The mutations c l ea r ly", "underscore_trick": " position_these cleavages_would alter the sequences_at the_3'_end of_the_minus strand and_as a result_have a drastic impact_on the ability_of_IN to catalyze strand transfer. The sequence from the 3? ends of the minus_strand_cDNA from_Tf1_particles_was determined using ligation mediated_PCR. The mutations clearly"}
{"text": " (e.g., osmotic and mechanical properties, state of hydration, charge density) must be characterized on distance scales below 100 nm. Understanding the interaction of polyelectrolytes with ions is critical to clarifying the basic physics of ion binding as well as physical mechanisms affecting a large number of biological processes. To determine", "synonym_substitution": "(e.g., osmotic and mechanical properties, state of hydration, charge concentration) must be qualify on distance scales below 100 nm. understand the interaction of polyelectrolyte with ions is critical to clarifying the basic physics of ion tie down as well as physical mechanism affecting a large issue of biological processes. To determine", "butter_fingers": " (e.g., osmotic and mechanical kroperties, state of hydretion, cgarge devsity) must be characterized ln distqnce scales below 100 nm. Jnderstanfing the inttraction of polyelectrolybzs wifm ionv is critical tp clarifyitg the basic pvyries of ion binding as well as physicaj mechamidms affecting w laggq nujber of biological processes. To defermine", "random_deletion": "(e.g., osmotic and mechanical properties, state of density) be characterized distance scales below of with ions is to clarifying the physics of ion binding as well physical mechanisms affecting a large number of biological processes. To determine", "change_char_case": " (e.g., osmotic and mechanical proPerties, staTe of hYdrAtiOn, CharGe deNsity) must be chaRActeRized on distance scales bElow 100 nM. UNDersTAnDing tHe interACtION of PoLyEleCtROlYtes wIth Ions is cRitical to cLarIfYing the basic PHySics of ion bIndIng as well as pHysIcal meChAniSMs affEctIng a lArge nuMBer of bIological PrOCesses. tO determINE", "whitespace_perturbation": " (e.g., osmotic and mechan ical prope rties , s tat eof h ydra tion, charge d e nsit y) must be characteriz ed on  d i stan c escale s below 10 0 nm.  U nd ers ta n di ng th e i nteract ion of pol yel ec trolytes wit h  i ons is cri tic al to clarif yin g theba sic physi csof io n bind i ng aswell as p hy s ical m e chanism s af fect ing a large numbe r  o f  biological pr ocesse s. To d ete rmi ne", "underscore_trick": " (e.g.,_osmotic and_mechanical properties, state of_hydration, charge_density)_must be_characterized_on distance scales_below 100 nm._Understanding the interaction of_polyelectrolytes with ions_is_critical to clarifying the basic physics of ion binding as well as physical mechanisms_affecting_a large_number_of_biological processes. To determine"}
{"text": "al sex steroids during normal brain development. The final analysis of this data is being completed with a manuscript in preparation. The Molecular Basis of Inherited Reproductive Disorders Human and animal models have identified a number of genes responsible for IGD, but more than half of patients with clinical evidence of the disorder do not", "synonym_substitution": "al sex steroids during normal brain development. The concluding psychoanalysis of this datum is being completed with a manuscript in preparation. The Molecular Basis of Inherited Reproductive Disorders Human and animal models have name a number of genes creditworthy for IGD, but more than half of patients with clinical evidence of the disorder make not", "butter_fingers": "al dex steroids during normxl brain develokmwnt. Thx final analysir of this data is being comppered wuth a manuscript in prdparation. The Molwculer Basis of Inhecjted Reixoducflve Dnsirders Human akd animal mmdels have idettkfned a number of genes responsible fow IGD, bit more than hals of [atisnts with clinical evidence of the disordtr do not", "random_deletion": "al sex steroids during normal brain development. analysis this data being completed with Molecular of Inherited Reproductive Human and animal have identified a number of genes for IGD, but more than half of patients with clinical evidence of the do not", "change_char_case": "al sex steroids during normal Brain develOpmenT. ThE fiNaL anaLysiS of this data is bEIng cOmpleted with a manuscripT in prEpARatiON. THe MolEcular BASiS OF InHeRiTed rePRoDuctiVe DIsorderS Human and aNimAl Models have idENtIfied a numbEr oF genes responSibLe for IgD, But MOre thAn hAlf of PatienTS with cLinical evIdENce of tHE disordER Do Not", "whitespace_perturbation": "al sex steroids during nor mal braindevel opm ent .Thefina l analysis oft hisdata is being complete d wit ha  man u sc riptin prep a ra t i on.  T he  Mo le c ul ar Ba sis  of Inh erited Rep rod uc tive Disorde r sHuman andani mal models h ave  ident if ied a num ber  of g enes r e sponsi ble for I GD ,  but m o re than h al f of  patients with cl i ni c al evidence of  the d is o rd e r  do  no t", "underscore_trick": "al sex_steroids during_normal brain development. The_final analysis_of_this data_is_being completed with_a manuscript in_preparation. The Molecular Basis_of Inherited Reproductive_Disorders_Human and animal models have identified a number of genes responsible for IGD, but_more_than half_of_patients_with clinical evidence of the_disorder do not"}
{"text": ", 2007). We found that subjects with confirmed reversal, or recovery from HH with sustained endogenous LH pulsatility, are responsive to IV bolus infusions of kisspeptin, a neuropeptide known to be a key stimulus of GnRH release in the human. On the other hand, subjects who relapse from their", "synonym_substitution": ", 2007). We found that subjects with confirmed reversal, or recovery from HH with free burning endogenous LH pulsatility, are reactive to IV bolus infusion of kisspeptin, a neuropeptide known to be a cardinal stimulus of GnRH passing in the human. On the early hand, subjects who relapse from their", "butter_fingers": ", 2007). Wf found that subjects wiuh confirmed revetsql, or cecoverg from HF with sustained endogenous PH pulsqtility, are responsive to IV bopus infuwionw of kisspe'fin, a ncbropelbide niown to be a kei stimulus ox GnRH release iv che human. On the other hand, subjects who rekaose from their", "random_deletion": ", 2007). We found that subjects with or from HH sustained endogenous LH bolus of kisspeptin, a known to be key stimulus of GnRH release in human. On the other hand, subjects who relapse from their", "change_char_case": ", 2007). We found that subjects with coNfirmed revErsal, Or rEcoVeRy frOm HH With sustained eNDogeNous LH pulsatility, are reSponsIvE To IV BOlUs infUsions oF KiSSPepTiN, a NeuRoPEpTide kNowN to be a kEy stimulus Of GNRh release in thE HuMan. On the otHer Hand, subjects Who RelapsE fRom THeir", "whitespace_perturbation": ", 2007). We found that sub jects with  conf irm edre vers al,or recovery fr o m HH  with sustained endoge nousLH puls a ti lity,  are re s po n s ive  t oIVbo l us  infu sio ns of k isspeptin,  ane uropeptide k n ow n to be akey  stimulus of  Gn RH rel ea sei n the  hu man.On the otherhand, sub je c ts who relapse f ro m th eir", "underscore_trick": ", 2007)._We found_that subjects with confirmed_reversal, or_recovery_from HH_with_sustained endogenous LH_pulsatility, are responsive_to IV bolus infusions_of kisspeptin, a_neuropeptide_known to be a key stimulus of GnRH release in the human. On the_other_hand, subjects_who_relapse_from their"}
{"text": " TLR4 form homo- or hetero-dimers, which can recognize various bacterial lipopeptides. These TLRs on the cell surface of leukocytes regulate chemotaxis, phagocytosis, and immune activation. TLR ligand LPS at 0.02 ng/ml over 15 min inhibited chemotactic response of CCR2, CXCR4", "synonym_substitution": "TLR4 form homo- or hetero - dimers, which can recognize various bacterial lipopeptides. These TLRs on the cell open of leukocyte regulate chemotaxis, phagocytosis, and immune activation. TLR ligand LPS at 0.02 nanogram / ml over 15 min inhibit chemotactic response of CCR2, CXCR4", "butter_fingers": " TLG4 form homo- or hetero-dimtrs, which can recognize tarious bacterixl lipopeptides. These TLRs oi thw celo surface of leukocyter regulatv chemotazis, khagocytosis, and mjmune agcivatjln. TNC ligand LPS at 0.02 ng/ml oves 15 min inhibitad ckemotactic response of CCR2, CXCR4", "random_deletion": "TLR4 form homo- or hetero-dimers, which can bacterial These TLRs the cell surface and activation. TLR ligand at 0.02 ng/ml 15 min inhibited chemotactic response of CXCR4", "change_char_case": " TLR4 form homo- or hetero-dimers, Which can reCogniZe vAriOuS bacTeriAl lipopeptides. tHese tLRs on the cell surface of LeukoCyTEs reGUlAte chEmotaxiS, PhAGOcyToSiS, anD iMMuNe actIvaTion. TLR Ligand LPS aT 0.02 ng/Ml Over 15 min inhibITeD chemotactIc rEsponse of CCR2, cXCr4", "whitespace_perturbation": " TLR4 form homo- or hetero -dimers, w hichcan  re co gniz e va rious bacteria l  lip opeptides. These TLRson th ec ells ur faceof leuk o cy t e s r eg ul ate  c h em otaxi s,phagocy tosis, and  im mu ne activatio n .TLR ligand  LP S at 0.02 ng /ml  over15  mi n  inhi bit ed ch emotac t ic res ponse ofCC R 2, CXC R 4", "underscore_trick": " TLR4_form homo-_or hetero-dimers, which can_recognize various_bacterial_lipopeptides. These_TLRs_on the cell_surface of leukocytes_regulate chemotaxis, phagocytosis, and_immune activation. TLR_ligand_LPS at 0.02 ng/ml over 15 min inhibited chemotactic response of CCR2, CXCR4"}
{"text": " of drug resistance. The DCTD envisions using extending the proven principles of assay development, validation and clinical implementation to develop and validate clinical PD assays for known chemotherapeutic markers, and then to deploy these in the Phase 0 trial setting under the FDA's Exploratory IND Guidance in order to not only confirm the", "synonym_substitution": "of drug resistance. The DCTD envisions using extending the proven principle of assay growth, validation and clinical implementation to develop and validate clinical palladium assays for known chemotherapeutic markers, and then to deploy these in the Phase 0 test setting under the FDA's Exploratory IND Guidance in order to not merely confirm the", "butter_fingers": " of drug resistance. The DCTA envisions usiut exteiding tge provev principles of assay develo'menr, valudation and clinical ioplementanion to dwvelip and valivzte clikncal LF asveys for known cmemotherapegtic markers, atd tken to deploy these in the Phase 0 tryal setyijg under the FQA's Txpjorafory IND Guidance in order to not knly coifirm the", "random_deletion": "of drug resistance. The DCTD envisions using proven of assay validation and clinical clinical assays for known markers, and then deploy these in the Phase 0 setting under the FDA's Exploratory IND Guidance in order to not only confirm", "change_char_case": " of drug resistance. The DCTD enVisions usiNg extEndIng ThE proVen pRinciples of assAY devElopment, validation and cLinicAl IMpleMEnTatioN to deveLOp AND vaLiDaTe cLiNIcAl PD aSsaYs for knOwn chemothEraPeUtic markers, aND tHen to deploY thEse in the PhasE 0 trIal setTiNg uNDer thE FDa's ExpLoratoRY IND GuIdance in oRdER to not ONly confIRM tHe", "whitespace_perturbation": " of drug resistance. The D CTD envisi ons u sin g e xt endi ng t he proven prin c iple s of assay development , val id a tion an d cli nical i m pl e m ent at io n t od ev elopand  valida te clinica l P Dassays for k n ow n chemothe rap eutic marker s,and th en  to deplo y t hesein the Phase0 trial s et t ing un d er theF D A' s Ex ploratory IND Gui d an c e in order tonot on ly co n f irm  th e", "underscore_trick": " of_drug resistance._The DCTD envisions using_extending the_proven_principles of_assay_development, validation and_clinical implementation to_develop and validate clinical_PD assays for_known_chemotherapeutic markers, and then to deploy these in the Phase 0 trial setting under_the_FDA's Exploratory_IND_Guidance_in order to not only_confirm the"}
{"text": " factors that place children at-risk for undue weight gain (2-14). We have recently examined how obesity and thyroid hormone (4) are interrelated as well as how leptin impacts bone in children (2) Two recent initiatives target insulin resistance. One trial studied the role of depressive symptoms in childrens insulin resistance.", "synonym_substitution": "factors that place children at - risk for excessive system of weights gain (2 - 14). We have recently examined how fleshiness and thyroid hormone (4) are interrelate as well as how leptin impacts bone in child (2) Two recent initiatives target insulin electric resistance. One trial studied the function of depressive symptoms in childrens insulin resistance.", "butter_fingers": " faftors that place childrek at-risk for undoe weighv gain (2-14). We have recently examined how obesivy abd thtroid hormone (4) are intdrrelated as well as iow leptin impacva bone lu chimfren (2) Two recent inltiatives tdrget insulin seridtance. One trial studied the role os deprexslve symptoms ig chplqrena insulin resistance.", "random_deletion": "factors that place children at-risk for undue (2-14). have recently how obesity and as as how leptin bone in children Two recent initiatives target insulin resistance. trial studied the role of depressive symptoms in childrens insulin resistance.", "change_char_case": " factors that place children aT-risk for unDue weIghT gaIn (2-14). we haVe reCently examined HOw obEsity and thyroid hormone (4) Are inTeRRelaTEd As welL as how lEPtIN ImpAcTs BonE iN ChIldreN (2) TwO recent InitiativeS taRgEt insulin resIStAnce. One triAl sTudied the rolE of DepresSiVe sYMptomS in ChildRens inSUlin reSistance.", "whitespace_perturbation": " factors that place childr en at-risk  forund uewe ight  gai n (2-14). We h a ve r ecently examined how o besit ya nd t h yr oid h ormone( 4) a rein te rre la t ed  as w ell  as how  leptin im pac ts  bone in chi l dr en (2) Two  re cent initiat ive s targ et  in s ulinres istan ce. On e  trial  studiedth e  roleo f depre s s iv e sy mptoms in childre n si nsulin resista nce.", "underscore_trick": " factors_that place_children at-risk for undue_weight gain_(2-14)._We have_recently_examined how obesity_and thyroid hormone_(4) are interrelated as_well as how_leptin_impacts bone in children (2) Two recent initiatives target insulin resistance. One trial studied_the_role of_depressive_symptoms_in childrens insulin resistance."}
{"text": "G/M204V. This is because of the lack of the 4'-cyano group in ETV compared to CMCP. Thus, from the observation that the interactions of the RT of HBVETV-RL180M/S202G/M204V with M204V and D205 persist in both", "synonym_substitution": "G / M204V. This is because of the lack of the 4'-cyano group in ETV compared to CMCP. Thus, from the observation that the interactions of the RT of HBVETV - RL180M / S202G / M204V with M204V and D205 prevail in both", "butter_fingers": "G/M204V. This is because of the uack of the 4'-cyaui grou' in ETB compardd to CMCP. Thus, from the obsxrvarion ukat the interactions of the RN of HBVERV-RL180N/W202G/M204V with M204V and D205 persiab in yovh", "random_deletion": "G/M204V. This is because of the lack 4'-cyano in ETV to CMCP. Thus, interactions the RT of with M204V and persist in both", "change_char_case": "G/M204V. This is because of the lack Of the 4'-cyano Group In EtV cOmPareD to CmCP. Thus, from the OBserVation that the interactiOns of ThE rT of hbVeTV-RL180m/S202G/M204V wiTH M204v ANd D205 PeRsIst In BOtH", "whitespace_perturbation": "G/M204V. This is because o f the lack  of t he4'- cy anogrou p in ETV compa r ed t o CMCP. Thus, from the  obse rv a tion th at th e inter a ct i o nsof  t heRT of  HBVE TV- RL180M/ S202G/M204 V w it h M204V andD 20 5 persistinboth", "underscore_trick": "G/M204V. This_is because_of the lack of_the 4'-cyano_group_in ETV_compared_to CMCP. Thus,_from the observation_that the interactions of_the RT of_HBVETV-RL180M/S202G/M204V_with M204V and D205 persist in both"}
{"text": ". Other allelic variations we found in DAOA and COMT genes interact to increase risk for SZ and impaired DLPFC information processing. This again, demonstrated a functional yet statistically significant interaction between risk alleles in DAOA and COMT which may play a role in glutaminergic and dopaminergic dysregulation. Lastly a variant", "synonym_substitution": ". Other allelic variations we found in DAOA and COMT genes interact to increase hazard for SZ and afflicted DLPFC data processing. This again, demonstrated a functional yet statistically significant interaction between hazard alleles in DAOA and COMT which may play a role in glutaminergic and dopaminergic dysregulation. last a version", "butter_fingers": ". Otjer allelic variations wt found in DAOA aue COMT genes interacg to increase risk for SZ anv impairee DLPFC information prucessing. Nhis agaib, deninstrated e functional ysb staciwtically signinicant intesaction betweet fidk alleles in DAOA and COMT which mwy play a role in glutaiineggyc ahd dopaminergic dysregulation. Lastmy a vagiant", "random_deletion": ". Other allelic variations we found in COMT interact to risk for SZ This demonstrated a functional statistically significant interaction risk alleles in DAOA and COMT may play a role in glutaminergic and dopaminergic dysregulation. Lastly a variant", "change_char_case": ". Other allelic variations we fOund in DAOA And COmT gEneS iNterAct tO increase risk fOR SZ aNd impaired DLPFC informaTion pRoCEssiNG. THis agAin, demoNStRATed A fUnCtiOnAL yEt staTisTically SignificanT inTeRaction betweEN rIsk alleles In DaOA and COMT whIch May plaY a RolE In gluTamInergIc and dOPamineRgic dysreGuLAtion. LAStly a vaRIAnT", "whitespace_perturbation": ". Other allelic variations  we foundin DA OAand  C OMTgene s interact toi ncre ase risk for SZ and im paire dD LPFC in forma tion pr o ce s s ing .Th isag a in , dem ons trateda function alye t statistica l ly  significa ntinteractionbet ween r is k a l leles  in  DAOA  and C O MT whi ch may pl ay a role in glut a m in ergi c and dopaminergi c  d y sregulation. L astlyav ar i a nt", "underscore_trick": ". Other_allelic variations_we found in DAOA_and COMT_genes_interact to_increase_risk for SZ_and impaired DLPFC_information processing. This again,_demonstrated a functional_yet_statistically significant interaction between risk alleles in DAOA and COMT which may play a_role_in glutaminergic_and_dopaminergic_dysregulation. Lastly a variant"}
{"text": ", combined with the strategic decisions of its dedicated SAIC-Frederick support program to use only assay technologies that have proven clinical applicability and to apply diagnostic assay expertise and developmental principles to PD assays, have already yielded validated assays for several molecular targets since the program's inception in mid-2005. One of these assays accelerated", "synonym_substitution": ", combined with the strategic decisions of its dedicated SAIC - Frederick support platform to practice only assay technology that have prove clinical applicability and to apply diagnostic assay expertise and developmental principle to PD assay, have already yielded validate assays for several molecular target since the program's inception in mid-2005. One of these assay accelerate", "butter_fingers": ", colbined with the strategig decisions of ijs dediceted SAJC-Frederkck support program to use oily qssay technologies that havd proven blinical qpplmcability and to apply dlcgnosflc asvey expertise anc developmantal principlas tl PD assays, have already yielded vajidated adsays for sevetal mpjecumar targets since the program's incsption pn mid-2005. One of thexe assays accelerated", "random_deletion": ", combined with the strategic decisions of SAIC-Frederick program to only assay technologies and apply diagnostic assay and developmental principles PD assays, have already yielded validated for several molecular targets since the program's inception in mid-2005. One of these accelerated", "change_char_case": ", combined with the strategic dEcisions of Its deDicAteD SaIC-FRedeRick support proGRam tO use only assay technologIes thAt HAve pROvEn cliNical apPLiCABilItY aNd tO aPPlY diagNosTic assaY expertise And DeVelopmental pRInCiples to PD AssAys, have alreaDy yIelded VaLidATed asSayS for sEveral MOleculAr targets SiNCe the pROgram's iNCEpTion In mid-2005. One of these asSAyS Accelerated", "whitespace_perturbation": ", combined with the strate gic decisi ons o f i tsde dica tedSAIC-Frederick supp ort program to use onl y ass ay tech n ol ogies  that h a ve p rov en  c lin ic a lappli cab ility a nd to appl y d ia gnostic assa y  e xpertise a nddevelopmenta l p rincip le s t o  PD a ssa ys, h ave al r eady y ielded va li d ated a s says fo r se vera l molecular targe t ss ince the progr am's i nc e pt i o n i n m id-2005. O ne  of t h ese ass a ys a c cel e rated", "underscore_trick": ", combined_with the_strategic decisions of its_dedicated SAIC-Frederick_support_program to_use_only assay technologies_that have proven_clinical applicability and to_apply diagnostic assay_expertise_and developmental principles to PD assays, have already yielded validated assays for several molecular_targets_since the_program's_inception_in mid-2005. One of these_assays accelerated"}
{"text": " slices with an enzyme that disrupts PNNs enables synaptic potentiation in CA2 pyramidal neurons. CA2 and its surrounding regions are anatomically and molecularly very similar, and as such, these findings may therefore lead to identification of other critical molecular components in the pathways necessary for developmental changes in synaptic plasticity and development", "synonym_substitution": "slices with an enzyme that disrupts PNNs enables synaptic potentiation in CA2 pyramidal neurons. CA2 and its besiege region are anatomically and molecularly very similar, and as such, these findings may therefore run to identification of other critical molecular component in the pathways necessary for developmental changes in synaptic malleability and growth", "butter_fingers": " sllces with an enzyme that disrupts PNNs gnqbles vynaptjc potengiation in CA2 pyramidal neurlnw. CA2 qnd its surrounding reeions are anatomixallb and molecularlb very sliilad, and es such, these flndings may therefore leag go identification of other critical mjleculat fomponents in jhe psehwags necessary for developmental chahges in synaptic plaxticity and development", "random_deletion": "slices with an enzyme that disrupts PNNs potentiation CA2 pyramidal CA2 and its molecularly similar, and as these findings may lead to identification of other critical components in the pathways necessary for developmental changes in synaptic plasticity and development", "change_char_case": " slices with an enzyme that disRupts PNNs eNableS syNapTiC potEntiAtion in CA2 pyramIDal nEurons. CA2 and its surroundIng reGiONs arE AnAtomiCally anD MoLECulArLy VerY sIMiLar, anD as Such, theSe findings May ThErefore lead tO IdEntificatiOn oF other criticAl mOleculAr ComPOnentS in The paThways NEcessaRy for deveLoPMental CHanges iN SYnAptiC plasticity and devELoPMent", "whitespace_perturbation": " slices with an enzyme tha t disrupts  PNNs  en abl es  syn apti c potentiation in C A2 pyramidal neurons.CA2 a nd itss ur round ing reg i on s are  a na tom ic a ll y and  mo lecular ly very si mil ar , and as suc h ,these find ing s may theref ore  leadto  id e ntifi cat ion o f othe r  criti cal molec ul a r comp o nents i n th e pa thways necessaryf or developmentalchange si ns y nap tic  plasticit yand d e velopme n t", "underscore_trick": " slices_with an_enzyme that disrupts PNNs_enables synaptic_potentiation_in CA2_pyramidal_neurons. CA2 and_its surrounding regions_are anatomically and molecularly_very similar, and_as_such, these findings may therefore lead to identification of other critical molecular components in_the_pathways necessary_for_developmental_changes in synaptic plasticity and_development"}
{"text": "IP4 and CXCR4 and by reversal of Nef effect through siRNA knockdown of AIP4 or by a small molecular weight inhibitor of dynamin. Nef has been shown to inhibit agonist driven chemotaxis through CXCR4 and CCR5 receptors by subverting chemotactic signaling at multiple steps. We show that although Nef", "synonym_substitution": "IP4 and CXCR4 and by reversal of Nef effect through siRNA knockdown of AIP4 or by a small molecular weight inhibitor of dynamin. Nef has been testify to suppress agonist driven chemotaxis through CXCR4 and CCR5 receptors by sabotage chemotactic signal at multiple steps. We show that although Nef", "butter_fingers": "IP4 wnd CXCR4 and by reversal of Nef effect jheough viRNA inockdowv of AIP4 or by a small molecnlar weigyt inhibitor of dynamiv. Nef has been shiwn uo inhibit agonisv driven chemofwxis vhrough CXCR4 anc CCR5 rece[tors by subvestkny chemotactic signaling at multiple fteps. Wr dhow that althjugh Gef", "random_deletion": "IP4 and CXCR4 and by reversal of through knockdown of or by a dynamin. has been shown inhibit agonist driven through CXCR4 and CCR5 receptors by chemotactic signaling at multiple steps. We show that although Nef", "change_char_case": "IP4 and CXCR4 and by reversal of NEf effect thRough SiRnA kNoCkdoWn of aIP4 or by a small mOLecuLar weight inhibitor of dyNamin. neF Has bEEn Shown To inhibIT aGONisT dRiVen ChEMoTaxis ThrOugh CXCr4 and CCR5 recEptOrS by subvertinG ChEmotactic sIgnAling at multiPle Steps. WE sHow THat alThoUgh NeF", "whitespace_perturbation": "IP4 and CXCR4 and by rever sal of Nef  effe ctthr ou gh s iRNA  knockdown ofA IP4or by a small molecula r wei gh t  inh i bi tor o f dynam i n. N efha sbee ns ho wn to  in hibit a gonist dri ven  c hemotaxis th r ou gh CXCR4 a ndCCR5 recepto rsby sub ve rti n g che mot actic  signa l ing at  multiple  s t eps. W e  show t h a talth ough Nef", "underscore_trick": "IP4 and_CXCR4 and_by reversal of Nef_effect through_siRNA_knockdown of_AIP4_or by a_small molecular weight_inhibitor of dynamin. Nef_has been shown_to_inhibit agonist driven chemotaxis through CXCR4 and CCR5 receptors by subverting chemotactic signaling at_multiple_steps. We_show_that_although Nef"}
{"text": "C reference sequence. Consistent with previous studies investigating CRISPR-Cas9 off-target activity in mouse embryos and human iPSCs, our WGS-based analysis of potential Cas9 RNP-associated off-target mutational events in primary human CD34+ HSPCs suggests that genome-editing utilizing electroporated", "synonym_substitution": "C reference sequence. Consistent with former cogitation investigating CRISPR - Cas9 off - prey bodily process in mouse embryos and human iPSCs, our WGS - establish analysis of potential Cas9 RNP - associate off - target mutational events in basal human CD34 + HSPCs suggests that genome - editing use electroporated", "butter_fingers": "C rfference sequence. Consisuent with previous studixs inveatigatine CRISPR-Cas9 off-target activivy ib mouwe embryos and human iOSCs, our AGS-based anaotsis of povsntial Gcs9 RNL-wssoeieted off-target kutational events in prikafy human CD34+ HSPCs suggests that genomq-editinb ktilizing elecjropogaeed", "random_deletion": "C reference sequence. Consistent with previous studies off-target in mouse and human iPSCs, Cas9 off-target mutational events primary human CD34+ suggests that genome-editing utilizing electroporated", "change_char_case": "C reference sequence. ConsistEnt with preVious StuDieS iNvesTigaTing CRISPR-Cas9 oFF-tarGet activity in mouse embrYos anD hUMan ipsCS, our WgS-based ANaLYSis Of PoTenTiAL CAs9 RNP-AssOciated Off-target mUtaTiOnal events in PRiMary human Cd34+ HSpCs suggests tHat Genome-EdItiNG utilIziNg eleCtropoRAted", "whitespace_perturbation": "C reference sequence. Cons istent wit h pre vio usst udie s in vestigating CR I SPR- Cas9 off-target activi ty in  m o usee mb ryosand hum a ni P SCs ,ou r W GS - ba sed a nal ysis of  potential  Ca s9  RNP-associa t ed  off-targe t m utational ev ent s in p ri mar y  huma n C D34+HSPCss uggest s that ge no m e-edit i ng util i z in g el ectroporated", "underscore_trick": "C reference_sequence. Consistent_with previous studies investigating_CRISPR-Cas9 off-target_activity_in mouse_embryos_and human iPSCs,_our WGS-based analysis_of potential Cas9 RNP-associated_off-target mutational events_in_primary human CD34+ HSPCs suggests that genome-editing utilizing electroporated"}
{"text": " Since paxillin phosphorylation on tyrosine residues 31 and 118 mediates vinculin recruitment into FAs, we demonstrated that vinculin and the paxillin-vinculin interaction are essential to strengthen the molecular clutch and to enable mechanosensing over a wide range of ECM compliances. We demonstrated the physiological importance of", "synonym_substitution": "Since paxillin phosphorylation on tyrosine residues 31 and 118 mediates vinculin recruitment into FAs, we demonstrated that vinculin and the paxillin - vinculin interaction are essential to tone the molecular clutch bag and to enable mechanosensing over a wide range of ECM submission. We prove the physiological importance of", "butter_fingers": " Sijce paxillin phosphorylauion on tyrosine tewidues 31 and 118 mediater vinculin recruitment into HAs, qe denonstrated that vinculkn and thv paxillib-vinrulin interactioi are essentiam to vvrengthen the mplecular cnutch and to etaclz mechanosensing over a wide range os ECM cpmoliances. We deionsuraeed fhe physiological importance of", "random_deletion": "Since paxillin phosphorylation on tyrosine residues 31 mediates recruitment into we demonstrated that are to strengthen the clutch and to mechanosensing over a wide range of compliances. We demonstrated the physiological importance of", "change_char_case": " Since paxillin phosphorylatIon on tyrosIne reSidUes 31 AnD 118 medIateS vinculin recruITmenT into FAs, we demonstrated That vInCUlin ANd The paXillin-vINcULIn iNtErActIoN ArE esseNtiAl to strEngthen the MolEcUlar clutch anD To Enable mechAnoSensing over a WidE range Of eCM COmpliAncEs. We dEmonstRAted thE physioloGiCAl impoRTance of", "whitespace_perturbation": " Since paxillin phosphoryl ation on t yrosi neres id ues31 a nd 118 mediate s  vin culin recruitment into  FAs,  w e  dem o ns trate d thatv in c u lin  a nd  th ep ax illin -vi nculininteractio n a re  essential t o  s trengthenthe  molecular c lut ch and  t o e n ablemec hanos ensing over a  wide ran ge of ECM complia n c es . We  demonstrated the ph y siological imp ortanc eo f", "underscore_trick": " Since_paxillin phosphorylation_on tyrosine residues 31_and 118_mediates_vinculin recruitment_into_FAs, we demonstrated_that vinculin and_the paxillin-vinculin interaction are_essential to strengthen_the_molecular clutch and to enable mechanosensing over a wide range of ECM compliances. We_demonstrated_the physiological_importance_of"}
{"text": " environment, which can have profound effects on its physiology and morphology. Such susceptibility of the developing brain to environmental influence by sensory manipulation or to environmental toxicants is particularly pronounced during defined critical periods of postnatal life. On the one hand, this susceptibility makes the developing brain particularly vulnerable to toxic insults. On the other hand, the", "synonym_substitution": "environment, which can have profound effects on its physiology and morphology. Such susceptibility of the developing mind to environmental influence by centripetal manipulation or to environmental toxicants is particularly pronounce during defined critical periods of postnatal life sentence. On the one handwriting, this susceptibility makes the developing brain particularly vulnerable to toxic insult. On the other hand, the", "butter_fingers": " engironment, which can have profound effecjs on itv physjology avd morphology. Such susceptibmlitt of uke developing brain go envirojmental unflnence by sensory manipulation kv to zntironmental toxlcants is pdrticularly prmnuuuced during defined critical periods of posynwtal life. On tre omq hahd, this susceptibility makes the dsvelopiig brain particilarly vulnerable to toxic insklts. On the other jand, the", "random_deletion": "environment, which can have profound effects on and Such susceptibility the developing brain manipulation to environmental toxicants particularly pronounced during critical periods of postnatal life. On one hand, this susceptibility makes the developing brain particularly vulnerable to toxic insults. the other hand, the", "change_char_case": " environment, which can have prOfound effeCts on Its PhySiOlogY and Morphology. Such SUscePtibility of the developiNg braIn TO envIRoNmentAl influENcE BY seNsOrY maNiPUlAtion Or tO enviroNmental toxIcaNtS is particulaRLy Pronounced DurIng defined crItiCal perIoDs oF PostnAtaL life. on the oNE hand, tHis suscepTiBIlity mAKes the dEVElOpinG brain particularlY VuLNerable to toxic InsultS. ON ThE OTheR haNd, the", "whitespace_perturbation": " environment, which can ha ve profoun d eff ect s o nitsphys iology and mor p holo gy. Such susceptibilit y ofth e  dev e lo pingbrain t o  e n v iro nm en tal  i n fl uence  by  sensor y manipula tio nor to enviro n me ntal toxic ant s is particu lar ly pro no unc e d dur ing  defi ned cr i ticalperiods o fp ostnat a l life. O ntheone hand, this su s ce p tibility makes  the d ev e lo p i ngbra in particu la rly v u lnerabl e  t o t oxi c  insults. Onthe other h a nd,  the", "underscore_trick": " environment,_which can_have profound effects on_its physiology_and_morphology. Such_susceptibility_of the developing_brain to environmental_influence by sensory manipulation_or to environmental_toxicants_is particularly pronounced during defined critical periods of postnatal life. On the one hand,_this_susceptibility makes_the_developing_brain particularly vulnerable to toxic_insults. On the other hand,_the"}
{"text": ", IL-6 receptor-alpha (IL-6R), and the type II IL-1 decoy receptor (IL-1RII) can all be inhibited by hydroxamic acid based zinc metalloprotease inhibitors, we hypothesized that ARTS-1 might also regulate IL-6R and IL-1R", "synonym_substitution": ", IL-6 receptor - alpha (IL-6R), and the type II IL-1 decoy receptor (IL-1RII) can all be inhibited by hydroxamic acid free-base zinc metalloprotease inhibitor, we hypothesized that ARTS-1 might also determine IL-6R and IL-1R", "butter_fingers": ", IL-6 receptor-alpha (IL-6R), and tme type II IL-1 deeiy recxptor (IM-1RII) can all be inhibited by hydroxalix acie based zinc metalloprutease injibitors, we iypothesized thav ARTS-1 mlyht amdo rzgnlate IL-6R and IK-1R", "random_deletion": ", IL-6 receptor-alpha (IL-6R), and the type decoy (IL-1RII) can be inhibited by inhibitors, hypothesized that ARTS-1 also regulate IL-6R IL-1R", "change_char_case": ", IL-6 receptor-alpha (IL-6R), and the tYpe II IL-1 decOy recEptOr (Il-1RiI) caN all Be inhibited by hYDroxAmic acid based zinc metalLoproTeASe inHIbItors, We hypotHEsIZEd tHaT ArTS-1 MiGHt Also rEguLate IL-6R And IL-1R", "whitespace_perturbation": ", IL-6 receptor-alpha (IL- 6R), and t he ty peIIIL -1 d ecoy  receptor (IL- 1 RII)  can all be inhibitedby hy dr o xami c  a cid b ased zi n cm e tal lo pr ote as e  i nhibi tor s, we h ypothesize d t ha t ARTS-1 mig h talso regul ate  IL-6R and I L-1 R", "underscore_trick": ", IL-6_receptor-alpha (IL-6R),_and the type II_IL-1 decoy_receptor_(IL-1RII) can_all_be inhibited by_hydroxamic acid based_zinc metalloprotease inhibitors, we_hypothesized that ARTS-1_might_also regulate IL-6R and IL-1R"}
{"text": " to provide risk feedback to participants from Mexican American households in the Houston, TX area. We successfully recruited 497 participants for baseline assessments (162 households), 481 participants completed the 1-month follow-up assessment and 461 participants completed the 6-month follow-up assessment. Recent efforts have focused on analyzing these data to identify how", "synonym_substitution": "to provide risk feedback to participants from Mexican American households in the Houston, TX sphere. We successfully recruit 497 participants for baseline assessment (162 family), 481 participants completed the 1 - month trace - up assessment and 461 participants complete the 6 - month follow - up judgment. Recent efforts have concenter on analyzing these data to identify how", "butter_fingers": " to provide risk feedback tu participants yeom Meeican Ajerican fouseholds in the Houston, TX aeea. Wt successfully recrjited 497 pagticipantw foc baseline assessments (162 mjusegllds), 481 participants gompleted tve 1-month follof-uo cssessment and 461 participants completqd the 6-kojth follow-up afsesxient. Gegent efforts have focused on anamyzing uhese data to idenyify how", "random_deletion": "to provide risk feedback to participants from households the Houston, area. We successfully assessments households), 481 participants the 1-month follow-up and 461 participants completed the 6-month assessment. Recent efforts have focused on analyzing these data to identify how", "change_char_case": " to provide risk feedback to paRticipants From MExiCan amEricAn hoUseholds in the HOUstoN, TX area. We successfully rEcruiTeD 497 PartICiPants For baseLInE ASseSsMeNts (162 HoUSeHolds), 481 ParTicipanTs completeD thE 1-mOnth follow-up ASsEssment and 461 ParTicipants comPleTed the 6-MoNth FOllow-Up aSsessMent. ReCEnt effOrts have fOcUSed on aNAlyzing THEsE datA to identify how", "whitespace_perturbation": " to provide risk feedbackto partici pants  fr omMe xica n Am erican househo l ds i n the Houston, TX area . Wesu c cess f ul ly re cruited 49 7 par ti ci pan ts fo r bas eli ne asse ssments (1 62ho useholds), 4 8 1participan tscompleted th e 1 -month  f oll o w-upass essme nt and 461 pa rticipant sc omplet e d the 6 - m on th f ollow-up assessme n t. Recent efforts  havefo c us e d  on  an alyzing th es e dat a  to ide n ti f y how ", "underscore_trick": " to_provide risk_feedback to participants from_Mexican American_households_in the_Houston,_TX area. We_successfully recruited 497_participants for baseline assessments_(162 households), 481_participants_completed the 1-month follow-up assessment and 461 participants completed the 6-month follow-up assessment. Recent_efforts_have focused_on_analyzing_these data to identify how"}
{"text": " SI-NETs. Recent results identified multifocal aberrant crypt-containing endocrine cell clusters (ACECs) that contain crypt EC cell microtumors in patients with familial SI-NETs. RNA in situ hybridization revealed expression of the EC cell and reserve stem cell genes TPH1, BMI1, HOPX,", "synonym_substitution": "SI - NETs. Recent results identified multifocal aberrant crypt - containing hormone cellular telephone clusters (ACECs) that contain crypt EC cellular telephone microtumors in patients with familial SI - NETs. RNA in situ hybridization unwrap expression of the EC cellular telephone and reserve bow cell gene TPH1, BMI1, HOPX,", "butter_fingers": " SI-JETs. Recent results idenuified multifocal aberrait crypf-containkng endocrine cell clusters (ECECw) thau contain crypt EC zell micrltumors un petients with fammmial SI-KZTs. RHW in witu hybridizajion revealeg expression ox ghz EC cell and reserve stem cell genef TPH1, BKI1, HOPX,", "random_deletion": "SI-NETs. Recent results identified multifocal aberrant crypt-containing clusters that contain EC cell microtumors RNA situ hybridization revealed of the EC and reserve stem cell genes TPH1, HOPX,", "change_char_case": " SI-NETs. Recent results identiFied multifOcal aBerRanT cRypt-ContAining endocrinE Cell Clusters (ACECs) that contaIn cryPt ec celL MiCrotuMors in pATiENTs wItH fAmiLiAL Si-NETs. rNA In situ hYbridizatiOn rEvEaled expressIOn Of the EC celL anD reserve stem CelL genes tPh1, BMi1, hOPX,", "whitespace_perturbation": " SI-NETs. Recent results i dentifiedmulti foc alab erra nt c rypt-containin g  end ocrine cell clusters ( ACECs )t hatc on taincrypt E C  c e l l m ic ro tum or s  i n pat ien ts with  familialSI- NE Ts. RNA in s i tu  hybridiza tio n revealed e xpr ession  o f t h e ECcel l and  reser v e stem  cell gen es TPH1,B MI1, HO P X ,", "underscore_trick": " SI-NETs._Recent results_identified multifocal aberrant crypt-containing_endocrine cell_clusters_(ACECs) that_contain_crypt EC cell_microtumors in patients_with familial SI-NETs. RNA_in situ hybridization_revealed_expression of the EC cell and reserve stem cell genes TPH1, BMI1, HOPX,"}
{"text": ". This suggests these MLV variants evolved to adapt to host receptor polymorphisms, to circumvent blocks by competing viruses or to avoid host-encoded envelope glycoproteins acquired for defense. In another series of experiments we characterized pathogenic and nonpathogenic MLVs of polytropic host range. Ecotropic, xenotropic and polytropic", "synonym_substitution": ". This suggests these MLV variants evolved to adapt to server sense organ polymorphisms, to circumvent block by compete viruses or to avoid host - encode envelope glycoprotein acquired for defense. In another series of experiments we characterized infective and nonpathogenic MLVs of polytropic host range. Ecotropic, xenotropic and polytropic", "butter_fingers": ". Thls suggests these MLV vaviants evolved to adapt to hoat recepgor polymorphisms, to circumvxnt vlockw by competing viruses or to avlid host-wncoved envelope glyrkproteikf acsmired hor defense. In snother sesies of experikevtd we characterized pathogenic and njnpathobejic MLVs of pojytrp[ic gost range. Ecotropic, xenotropic ans polytgopic", "random_deletion": ". This suggests these MLV variants evolved to receptor polymorphisms, circumvent blocks by host-encoded glycoproteins acquired for In another series experiments we characterized pathogenic and nonpathogenic of polytropic host range. Ecotropic, xenotropic and polytropic", "change_char_case": ". This suggests these MLV variaNts evolved To adaPt tO hoSt RecePtor Polymorphisms, tO CircUmvent blocks by competinG viruSeS Or to AVoId hosT-encodeD EnVELopE gLyCopRoTEiNs acqUirEd for deFense. In anoTheR sEries of experIMeNts we charaCteRized pathogeNic And nonPaThoGEnic MlVs Of polYtropiC Host raNge. EcotroPiC, XenotrOPic and pOLYtRopiC", "whitespace_perturbation": ". This suggests these MLVvariants e volve d t o a da pt t o ho st receptor po l ymor phisms, to circumventblock sb y co m pe tingviruses or t o a vo id  ho st - en coded  en velopeglycoprote ins  a cquired ford ef ense. In a not her series o f e xperim en tsw e cha rac teriz ed pat h ogenic  and nonp at h ogenic MLVs of p ol ytro pic host range. E c ot r opic, xenotrop ic and  p o ly t r opi c", "underscore_trick": ". This_suggests these_MLV variants evolved to_adapt to_host_receptor polymorphisms,_to_circumvent blocks by_competing viruses or_to avoid host-encoded envelope_glycoproteins acquired for_defense._In another series of experiments we characterized pathogenic and nonpathogenic MLVs of polytropic host_range._Ecotropic, xenotropic_and_polytropic"}
{"text": "1 susceptibility variants in wild mice and described the geographic and species distribution of these Mus Xpr1 variants. Five of these receptors restrict entry by two or more of the virus host range variants that rely on XPR1, and all of these receptors evolved in populations exposed to X-MLVs. Virtually all mammalian species", "synonym_substitution": "1 susceptibility variants in wild mice and described the geographic and species distribution of these Mus Xpr1 random variable. Five of these receptor restrict entry by two or more of the virus host image variants that rely on XPR1, and all of these sense organ evolve in populations exposed to X - MLVs. Virtually all mammalian coinage", "butter_fingers": "1 sudceptibility variants in wild mice and bwscribxd the feographkc and species distribution lf thest Mus Xpr1 variants. Wive of tjese recwptocs restrict entrb by two or modc of chx virus host rakge variantv that rely on XOR1, and all of these receptors evolved in popilwtions exposed to Q-MJVs. Bpruually all mammalian species", "random_deletion": "1 susceptibility variants in wild mice and geographic species distribution these Mus Xpr1 restrict by two or of the virus range variants that rely on XPR1, all of these receptors evolved in populations exposed to X-MLVs. Virtually all mammalian", "change_char_case": "1 susceptibility variants in wIld mice and DescrIbeD thE gEogrAphiC and species disTRibuTion of these Mus Xpr1 variaNts. FiVe OF theSE rEceptOrs restRIcT ENtrY bY tWo oR mORe Of the VirUs host rAnge varianTs tHaT rely on XPR1, anD AlL of these reCepTors evolved iN poPulatiOnS exPOsed tO X-MlVs. ViRtuallY All mamMalian speCiES", "whitespace_perturbation": "1 susceptibility variantsin wild mi ce an d d esc ri bedthegeographic and spec ies distribution of th ese M us Xpr1 va riant s. Five of t hes ere cep to r srestr ict  entryby two ormor eof the virus ho st range v ari ants that re lyon XPR 1,  an d  allofthese  recep t ors ev olved inpo p ulatio n s expos e d  t o X- MLVs. Virtually a l lm ammalian speci es", "underscore_trick": "1 susceptibility_variants in_wild mice and described_the geographic_and_species distribution_of_these Mus Xpr1_variants. Five of_these receptors restrict entry_by two or_more_of the virus host range variants that rely on XPR1, and all of these_receptors_evolved in_populations_exposed_to X-MLVs. Virtually all mammalian_species"}
{"text": " transcription was not important for target site activity. We next considered whether transcription factors themselves were directing the integration of Tf1. To identify positions where factors bind in the promoter of Ade6, we used micrococcal nuclease mapping. We observed a strong correlation between micrococcal sensitive sites and the position of the prominent", "synonym_substitution": "transcription was not important for target site natural process. We next view whether transcription divisor themselves were target the integration of Tf1. To identify position where agent bind in the showman of Ade6, we use micrococcal nuclease mapping. We note a strong correlation between micrococcal sensitive sites and the position of the prominent", "butter_fingers": " trwnscription was not impovtant for target site artivity. We next considered whether transcri'tiob facujrs themselves werd directijg the ibtegcation of Tf1. To msentify positjlns chxre factors binc in the psomoter of Ade6, wd bsed micrococcal nuclease mapping. We observrd a strong corrglatipg befween micrococcal sensitive sites znd the position of yhe prominent", "random_deletion": "transcription was not important for target site next whether transcription themselves were directing identify where factors bind the promoter of we used micrococcal nuclease mapping. We a strong correlation between micrococcal sensitive sites and the position of the prominent", "change_char_case": " transcription was not importAnt for targEt sitE acTivItY. We nExt cOnsidered whethER traNscription factors themsElves WeRE dirECtIng thE integrATiON Of TF1. TO iDenTiFY pOsitiOns Where faCtors bind iN thE pRomoter of Ade6, WE uSed microcoCcaL nuclease mapPinG. We obsErVed A StronG coRrelaTion beTWeen miCrococcal SeNSitive SItes and THE pOsitIon of the prominent", "whitespace_perturbation": " transcription was not imp ortant for  targ etsit eacti vity . We next cons i dere d whether transcriptio n fac to r s th e ms elves  were d i re c t ing  t he  in te g ra tionofTf1. To  identifypos it ions where f a ct ors bind i n t he promoterofAde6,we  us e d mic roc occal  nucle a se map ping. Weob s erveda  strong c or rela tion between micr o co c cal sensitivesitesan d  t h e  po sit ion of the  p romin e nt", "underscore_trick": " transcription_was not_important for target site_activity. We_next_considered whether_transcription_factors themselves were_directing the integration_of Tf1. To identify_positions where factors_bind_in the promoter of Ade6, we used micrococcal nuclease mapping. We observed a strong_correlation_between micrococcal_sensitive_sites_and the position of the_prominent"}
{"text": " cells, how variations in these recognition and signaling events leads to desirable versus undesirable forms of immunity, and how we can manipulate these events to augment useful immune responses and inhibit damaging ones. Our studies currently focus on biochemical regulatory pathways that help T cells discriminate between self- and foreign peptide:MHC molecule complexes, on the explicit", "synonym_substitution": "cells, how variations in these recognition and signaling event go to desirable versus undesirable forms of immunity, and how we can manipulate these event to augment useful immune responses and suppress damaging ones. Our studies currently concentrate on biochemical regulatory pathways that avail T cells discriminate between self- and alien peptide: MHC molecule complexes, on the explicit", "butter_fingers": " cepls, how variations in thtse recognition aue signeling ebents lexds to desirable versus undedieable forms of immunity, and how we cwn manipylatt these events to augment usefum immbnx responses and inhibit ddmaging ones. Ogr scudies currently focus on biochemicaj regulstlry pathways trat nqlp F cells discriminate between self- znd fortign peptide:MHC mokecule complexes, on the exoliclt", "random_deletion": "cells, how variations in these recognition and leads desirable versus forms of immunity, these to augment useful responses and inhibit ones. Our studies currently focus on regulatory pathways that help T cells discriminate between self- and foreign peptide:MHC molecule on the explicit", "change_char_case": " cells, how variations in these RecognitioN and sIgnAliNg EvenTs leAds to desirable VErsuS undesirable forms of immUnity, AnD How wE CaN maniPulate tHEsE EVenTs To AugMeNT uSeful ImmUne respOnses and inHibIt Damaging ones. oUr Studies curRenTly focus on biOchEmical ReGulATory pAthWays tHat helP t cells DiscriminAtE BetweeN Self- and FOReIgn pEptide:MHC molecule COmPLexes, on the explIcit", "whitespace_perturbation": " cells, how variations inthese reco gniti onand  s igna ling  events leadst o de sirable versus undesir ablefo r ms o f  i mmuni ty, and ho w weca nman ip u la te th ese  events  to augmen t u se ful immune r e sp onses andinh ibit damagin g o nes. O ur  st u diescur rentl y focu s  on bi ochemical  r e gulato r y pathw a y sthat  help T cells dis c ri m inate betweenself-an d  f o r eig n p eptide:MHC  m olecu l e compl e xe s , ont he explicit", "underscore_trick": " cells,_how variations_in these recognition and_signaling events_leads_to desirable_versus_undesirable forms of_immunity, and how_we can manipulate these_events to augment_useful_immune responses and inhibit damaging ones. Our studies currently focus on biochemical regulatory pathways_that_help T_cells_discriminate_between self- and foreign peptide:MHC_molecule complexes, on the explicit"}
{"text": " in MOLT-4 cells and the same was seen at 100 microM in Daudi cells. There was also a sharp reudction in the amount of mtDNA at 10 and 100 microM in MOLT-4 and Daudi cells, respectively. By contrast, there was no sharp reduction when the cells were cultivated", "synonym_substitution": "in MOLT-4 cells and the same was seen at 100 microM in Daudi cells. There be besides a sharp reudction in the amount of mtDNA at 10 and 100 microM in MOLT-4 and Daudi cell, respectively. By line, there was no sharp reduction when the cellular telephone were cultivated", "butter_fingers": " in MOLT-4 cells and the same was seen at 100 mnxroM ii Daudi cells. Tfere was also a sharp reudctmon un tht amount of mtDNA ag 10 and 100 mpcroM in NOLT-4 qnd Daudi rslls, respectibcly. Bv rontrast, there eas no shasp reduction wvev che cells were cultivated", "random_deletion": "in MOLT-4 cells and the same was 100 in Daudi There was also amount mtDNA at 10 100 microM in and Daudi cells, respectively. By contrast, was no sharp reduction when the cells were cultivated", "change_char_case": " in MOLT-4 cells and the same was sEen at 100 microm in DaUdi CelLs. therE was Also a sharp reudCTion In the amount of mtDNA at 10 anD 100 micrOM IN MOLt-4 AnD DaudI cells, rESpECTivElY. BY coNtRAsT, therE waS no sharP reduction WheN tHe cells were cULtIvated", "whitespace_perturbation": " in MOLT-4 cells and the s ame was se en at  10 0 m ic roMin D audi cells. Th e re w as also a sharp reudct ion i nt he a m ou nt of  mtDNAa t1 0  an d10 0 m ic r oM  in M OLT -4 andDaudi cell s,re spectively.B ycontrast,the re was no sh arp  reduc ti onw hen t hecells  werec ultiva ted", "underscore_trick": " in_MOLT-4 cells_and the same was_seen at_100_microM in_Daudi_cells. There was_also a sharp_reudction in the amount_of mtDNA at_10_and 100 microM in MOLT-4 and Daudi cells, respectively. By contrast, there was no_sharp_reduction when_the_cells_were cultivated"}
{"text": " established a challenge model using AGM and showed that two doses of NDV-HA conferred essentially complete protection against challenge with a high dose (7.2 log10 PFU) of HPAIV. The high level of restriction of HPAIV challenge virus was established by assay of nasal swabs and tracheal lav", "synonym_substitution": "established a challenge model using AGM and showed that two venereal disease of NDV - HA confer essentially complete protection against challenge with a gamey dose (7.2 log10 PFU) of HPAIV. The high horizontal surface of limitation of HPAIV challenge virus was established by assay of nasal swabs and tracheal lav", "butter_fingers": " eshablished a challenge moael using AGM aue showxd that two dosds of NDV-HA conferred essentmallt comkjete protection agxinst chaplenge wuth e high dose (7.2 log10 PFU) of M'AIV. Fme hiyh level of resttiction of H[AIV challenge vkrbs was established by assay of nasal swabs snf tracheal lav", "random_deletion": "established a challenge model using AGM and two of NDV-HA essentially complete protection dose log10 PFU) of The high level restriction of HPAIV challenge virus was by assay of nasal swabs and tracheal lav", "change_char_case": " established a challenge modeL using AGM aNd shoWed ThaT tWo doSes oF NDV-HA conferreD EsseNtially complete protectIon agAiNSt chALlEnge wIth a higH DoSE (7.2 Log10 pFu) oF HPaIv. thE high LevEl of resTriction of hPAiV Challenge virUS wAs establisHed By assay of nasAl sWabs anD tRacHEal laV", "whitespace_perturbation": " established a challenge m odel using  AGMand  sh ow ed t hattwo doses of N D V-HA  conferred essentially  comp le t e pr o te ction  agains t  c h a lle ng ewit ha  h igh d ose  (7.2 l og10 PFU)ofHP AIV. The hig h  l evel of re str iction of HP AIV  chall en gev iruswas  esta blishe d  by as say of na sa l  swabs and tra c h ea l la v", "underscore_trick": " established_a challenge_model using AGM and_showed that_two_doses of_NDV-HA_conferred essentially complete_protection against challenge_with a high dose_(7.2 log10 PFU)_of_HPAIV. The high level of restriction of HPAIV challenge virus was established by assay_of_nasal swabs_and_tracheal_lav"}
{"text": " suppressed the replication of wild-type HBV strains (HBVWT) as examined in HepG2.2.2.15.7 cells, HBVWT-plasmid-transfected Huh7 cells, and in HBVWT-exposed human-liver-chimeric-uPA+/+/SCID+/+", "synonym_substitution": "suppressed the replication of wild - type HBV tune (HBVWT) as probe in HepG2.2.2.15.7 cells, HBVWT - plasmid - transfected Huh7 cells, and in HBVWT - exposed human - liver - chimeric - uPA+/+/SCID+/+", "butter_fingers": " suopressed the replication of wild-type HBR straiis (HBVWF) as exaoined in HepG2.2.2.15.7 cells, HBVWT-pladmud-trabsfected Huh7 cells, and in HBVWT-vxposed hyman-ouver-chimermd-uPA+/+/SCID+/+", "random_deletion": "suppressed the replication of wild-type HBV strains examined HepG2.2.2.15.7 cells, Huh7 cells, and", "change_char_case": " suppressed the replication oF wild-type HbV strAinS (HBvWt) as eXamiNed in HepG2.2.2.15.7 cells, hbVWT-Plasmid-transfected Huh7 cElls, aNd IN HBVwt-eXposeD human-lIVeR-CHimErIc-UPA+/+/sCid+/+", "whitespace_perturbation": " suppressed the replicatio n of wild- typeHBV  st ra ins(HBV WT) as examine d  inHepG2.2.2.15.7 cells,HBVWT -p l asmi d -t ransf ected H u h7 c ell s,  a ndin HB VWT-e xpo sed hum an-liver-c him er ic-uPA+/+/SC I D+ /+", "underscore_trick": " suppressed_the replication_of wild-type HBV strains_(HBVWT) as_examined_in HepG2.2.2.15.7_cells,_HBVWT-plasmid-transfected Huh7 cells,_and in HBVWT-exposed_human-liver-chimeric-uPA+/+/SCID+/+"}
{"text": " biopolymer molecules and assemblies in their natural environment and to correlate the changes in the environmental conditions (e.g., ion concentration, ion valance, pH, temperature) with physical properties such as molecular conformation and osmotic pressure. These techniques simultaneously provide information about the size of different structural elements and their respective contribution to", "synonym_substitution": "biopolymer molecules and assemblies in their natural environment and to correlate the changes in the environmental condition (for example, ion concentration, ion valance, pH, temperature) with forcible properties such as molecular conformity and osmotic pressure. These techniques simultaneously supply information about the size of different geomorphologic elements and their respective contribution to", "butter_fingers": " bilpolymer molecules and arsemblies in thgie natucal envjronment and to correlate the changed un tht environmental conaitions (e.h., ion cobcenuration, ion valanrs, pH, temperathve) wich physical propgrties such ds molecular cmnwoxmation and osmotic pressure. These tqchniqurs simultaneousli proniqe ihformation about the size of diffedent stguctural elements and their respective contgibuhion to", "random_deletion": "biopolymer molecules and assemblies in their natural to the changes the environmental conditions pH, with physical properties as molecular conformation osmotic pressure. These techniques simultaneously provide about the size of different structural elements and their respective contribution to", "change_char_case": " biopolymer molecules and assEmblies in tHeir nAtuRal EnViroNmenT and to correlatE The cHanges in the environmentAl conDiTIons (E.G., iOn conCentratIOn, ION vaLaNcE, pH, TeMPeRaturE) wiTh physiCal propertIes SuCh as moleculaR CoNformation And Osmotic pressUre. these tEcHniQUes siMulTaneoUsly prOVide inFormation AbOUt the sIZe of difFEReNt stRuctural elements aND tHEir respective cOntribUtIOn TO", "whitespace_perturbation": " biopolymer molecules andassemblies  in t hei r n at ural  env ironment and t o  cor relate the changes inthe e nv i ronm e nt al co ndition s  ( e . g.,  i on  co nc e nt ratio n,ion val ance, pH,tem pe rature) with ph ysical pro per ties such as  mo lecula rcon f ormat ion  andosmoti c  press ure. Thes et echniq u es simu l t an eous ly provide inform a ti o n about the si ze ofdi f fe r e ntstr uctural el em entsa nd thei r  r e s p ect i ve contributi on to", "underscore_trick": " biopolymer_molecules and_assemblies in their natural_environment and_to_correlate the_changes_in the environmental_conditions (e.g., ion_concentration, ion valance, pH,_temperature) with physical_properties_such as molecular conformation and osmotic pressure. These techniques simultaneously provide information about the_size_of different_structural_elements_and their respective contribution to"}
{"text": " N-terminus of the surface subunit, and the cytoplasmic tail R peptide. Viral gag gene replacements are influenced by host restriction genes Fv1 and Apobec3. Pathogenic potential maps to the env transmembrane subunit segment encoding the N-heptad repeat (HR1). Molecular dynamics simulations identified three novel inter", "synonym_substitution": "N - terminus of the surface subunit, and the cytoplasmic tail radius peptide. Viral joke gene replacements are influenced by server limitation genes Fv1 and Apobec3. Pathogenic potential map to the env transmembrane subunit segment encode the N - seven repeat (HR1). Molecular dynamics simulations identify three novel inter", "butter_fingers": " N-tfrminus of the surface smbunit, and the citiplasmmc tail R peptiae. Viral gag gene replacemenvs aee indluenced by host restrkction gejes Fv1 abd Akobec3. Pathogenic 'ktential maps bo thz xnv transmembrake subunit vegment encoditg tke N-heptad repeat (HR1). Molecular dynamycs similwtions identifyed uhrqe nkneo inter", "random_deletion": "N-terminus of the surface subunit, and the R Viral gag replacements are influenced and Pathogenic potential maps the env transmembrane segment encoding the N-heptad repeat (HR1). dynamics simulations identified three novel inter", "change_char_case": " N-terminus of the surface subuNit, and the cYtoplAsmIc tAiL R pePtidE. Viral gag gene rEPlacEments are influenced by hOst reStRIctiON gEnes FV1 and ApoBEc3. pAThoGeNiC poTeNTiAl mapS to The env tRansmembraNe sUbUnit segment eNCoDing the N-hePtaD repeat (HR1). MolEcuLar dynAmIcs SImulaTioNs ideNtifieD Three nOvel inter", "whitespace_perturbation": " N-terminus of the surface  subunit,and t hecyt op lasm ic t ail R peptide. Vira l gag gene replacement s are  i n flue n ce d byhost re s tr i c tio nge nes  F v 1and A pob ec3. Pa thogenic p ote nt ial maps tot he  env trans mem brane subuni t s egment  e nco d ing t heN-hep tad re p eat (H R1). Mole cu l ar dyn a mics si m u la tion s identified thre e  n o vel inter", "underscore_trick": " N-terminus_of the_surface subunit, and the_cytoplasmic tail_R_peptide. Viral_gag_gene replacements are_influenced by host_restriction genes Fv1 and_Apobec3. Pathogenic potential_maps_to the env transmembrane subunit segment encoding the N-heptad repeat (HR1). Molecular dynamics simulations_identified_three novel_inter"}
{"text": " effect of Vif on APOBEC3G is modulated by CBF. We have cloned CBF from human cells. Also, since CBF is ubiquitously expressed in most cell types, we created stable CBF knock-down cell lines to be able to perform experiments on a CBF negative background. Several studies", "synonym_substitution": "effect of Vif on APOBEC3 G is modulated by CBF. We have cloned CBF from human cells. besides, since CBF is ubiquitously carry in most cell types, we create static CBF knock - down cell lines to be able to perform experiment on a CBF negative background. respective study", "butter_fingers": " efvect of Vif on APOBEC3G ir modulated by EVF. We iave clkned CBF from human cells. Also, since CVF is ubiquitously expressea in most cell types, xe created stablx CBF knock-dowh celn lines to be anle to perfmrm experimentv un a CBF negative background. Several ftudies", "random_deletion": "effect of Vif on APOBEC3G is modulated We cloned CBF human cells. Also, in cell types, we stable CBF knock-down lines to be able to perform on a CBF negative background. Several studies", "change_char_case": " effect of Vif on APOBEC3G is modUlated by CBf. We haVe cLonEd cBF fRom hUman cells. Also, sINce CbF is ubiquitously expresSed in MoST celL TyPes, we Created STaBLE CBf kNoCk-dOwN CeLl linEs tO be able To perform eXpeRiMents on a CBF nEGaTive backgrOunD. Several studIes", "whitespace_perturbation": " effect of Vif on APOBEC3G  is modula ted b y C BF.  W e ha ve c loned CBF from huma n cells. Also, since C BF is  u b iqui t ou sly e xpresse d  i n mos tce llty p es , wecre ated st able CBF k noc k- down cell li n es  to be abl e t o perform ex per iments  o n a CBF n ega tivebackgr o und. S everal st ud i es", "underscore_trick": " effect_of Vif_on APOBEC3G is modulated_by CBF._We_have cloned_CBF_from human cells._Also, since CBF_is ubiquitously expressed in_most cell types,_we_created stable CBF knock-down cell lines to be able to perform experiments on a_CBF_negative background._Several_studies"}
{"text": "V6-copGFP at either 48 hr or 36 hr pre- or 0.5 hr post-RNP electroporation. Gene edited cells were cultured for up to 28 days post-electroporation and periodically sampled for flow cytometry and genomic DNA (gDNA) extraction. Transduction of HSPCs prior to", "synonym_substitution": "V6 - copGFP at either 48 hr or 36 hr pre- or 0.5 hr post - RNP electroporation. Gene edited cell were culture for up to 28 days post - electroporation and sporadically sampled for stream cytometry and genomic DNA (gDNA) extraction. Transduction of HSPCs prior to", "butter_fingers": "V6-cooGFP at either 48 hr or 36 hv pre- or 0.5 hr posj-RBP elertroporztion. Geve edited cells were culturev foe up uj 28 days post-electruporation and peruodirally sampled foc flow cncometdn and jenomic DNA (gDNS) extractimn. Transductiot uf HSPCs prior to", "random_deletion": "V6-copGFP at either 48 hr or 36 or hr post-RNP Gene edited cells 28 post-electroporation and periodically for flow cytometry genomic DNA (gDNA) extraction. Transduction of prior to", "change_char_case": "V6-copGFP at either 48 hr or 36 hr pre- oR 0.5 hr post-RNP ElectRopOraTiOn. GeNe edIted cells were cULturEd for up to 28 days post-electRoporAtIOn anD PeRiodiCally saMPlED For FlOw CytOmETrY and gEnoMic DNA (gdNA) extractIon. trAnsduction of hsPcs prior to", "whitespace_perturbation": "V6-copGFP at either 48 hror 36 hr p re- o r 0 .5hr  pos t-RN P electroporat i on.Gene edited cells were  cult ur e d fo r  u p to28 days po s t -el ec tr opo ra t io n and  pe riodica lly sample d f or  flow cytome t ry  and genom icDNA (gDNA) e xtr action .Tra n sduct ion  of H SPCs p r ior to ", "underscore_trick": "V6-copGFP at_either 48_hr or 36 hr_pre- or_0.5_hr post-RNP_electroporation._Gene edited cells_were cultured for_up to 28 days_post-electroporation and periodically_sampled_for flow cytometry and genomic DNA (gDNA) extraction. Transduction of HSPCs prior to"}
{"text": " will be used in interpreting anisotropy decay experiments. This relatively new method has the potential for monitoring how proteins form multimers, and their stoichiometry in living cells. The generation of fluorescent protein anisotropy standards required the generation of a mutant variant of GFP that has the same fundamental structure as GFP but is not capable of participating in", "synonym_substitution": "will be used in interpreting anisotropy decay experiments. This relatively new method acting have the potential for monitoring how protein form multimers, and their stoichiometry in animation cells. The coevals of fluorescent protein anisotropy standards required the coevals of a mutant variant of GFP that has the like fundamental structure as GFP but is not capable of participating in", "butter_fingers": " wipl be used in interpretikg anisotropy deeqy expxrimenta. This rdlatively new method has the pitentual for monitoring how proteins form muotimtrs, and their stomdhiometvv in mlving rells. The generstion of fnuorescent prodekn anisotropy standards required the deneratooj of a mutant darisgt or GFP that has the same fundamentam strucuure as GFP but is not capable of participatlng ln", "random_deletion": "will be used in interpreting anisotropy decay relatively method has potential for monitoring their in living cells. generation of fluorescent anisotropy standards required the generation of mutant variant of GFP that has the same fundamental structure as GFP but not capable of participating in", "change_char_case": " will be used in interpreting aNisotropy dEcay eXpeRimEnTs. ThIs reLatively new metHOd haS the potential for monitoRing hOw PRoteINs Form mUltimerS, AnD THeiR sToIchIoMEtRy in lIviNg cells. the generatIon Of Fluorescent pROtEin anisotrOpy Standards reqUirEd the gEnEraTIon of A muTant vAriant OF GFP thAt has the sAmE FundamENtal strUCTuRe as gFP but is not capablE Of PArticipating in", "whitespace_perturbation": " will be used in interpret ing anisot ropydec ayex peri ment s. This relati v elynew method has the pot entia lf or m o ni torin g how p r ot e i nsfo rm  mu lt i me rs, a ndtheir s toichiomet ryin  living cell s .The genera tio n of fluores cen t prot ei n a n isotr opy  stan dardsr equire d the gen er a tion o f  a muta n t  v aria nt of GFP that ha s  t h e same fundame ntal s tr u ct u r e a s G FP but isno t cap a ble ofp ar t i c ipa t ing in", "underscore_trick": " will_be used_in interpreting anisotropy decay_experiments. This_relatively_new method_has_the potential for_monitoring how proteins_form multimers, and their_stoichiometry in living_cells._The generation of fluorescent protein anisotropy standards required the generation of a mutant variant_of_GFP that_has_the_same fundamental structure as GFP_but is not capable of_participating in"}
{"text": " marginal band of microtubules that extends down from the axon and loops throughout the synaptic terminal. This microtubule loop is structurally similar to those found in red blood cells. Using 3D confocal fluorescence, block-face serial scanning electron microscopy, and transmission electron microscopy we fully characterized this structure. We found that this microtubule structure associates with", "synonym_substitution": "marginal band of microtubules that extends down from the axon and iteration throughout the synaptic end. This microtubule loop is structurally similar to those establish in crimson blood cells. use 3D confocal fluorescence, auction block - face consecutive scan electron microscopy, and transmission electron microscopy we in full characterized this structure. We find oneself that this microtubule structure associates with", "butter_fingers": " magginal band of microtubuues that extends down hrom ths axon avd loops throughout the syna'tic termunal. This microtubule uoop is snructuraloy smmilar to those hkund in red bmlod eeols. Using 3D cokfocal fluosescence, block-xaze serial scanning electron microscopr, and ttajsmission elecjron kycroaboky we fully characterized this stducture. We found thay this microtubule structuge adsociates with", "random_deletion": "marginal band of microtubules that extends down axon loops throughout synaptic terminal. This to found in red cells. Using 3D fluorescence, block-face serial scanning electron microscopy, transmission electron microscopy we fully characterized this structure. We found that this microtubule associates with", "change_char_case": " marginal band of microtubuleS that extenDs dowN frOm tHe Axon And lOops throughout THe syNaptic terminal. This micrOtubuLe LOop iS StRuctuRally siMIlAR To tHoSe FouNd IN rEd bloOd cElls. UsiNg 3D confocaL flUoRescence, blocK-FaCe serial scAnnIng electron mIcrOscopy, AnD trANsmisSioN elecTron miCRoscopY we fully cHaRActeriZEd this sTRUcTure. we found that this miCRoTUbule structure AssociAtES wITH", "whitespace_perturbation": " marginal band of microtub ules thatexten dsdow nfrom  the  axon and loop s  thr oughout the synaptic t ermin al .  Thi s  m icrot ubule l o op i s s tr uc tur al l ysimil arto thos e found in  re dblood cells. Us ing 3D con foc al fluoresce nce , bloc k- fac e  seri alscann ing el e ctronmicroscop y, and tr a nsmissi o n  e lect ron microscopy we fu l ly characteriz ed thi ss tr u c tur e.We found t ha t thi s  microt u bu l e str u cture associa tes with", "underscore_trick": " marginal_band of_microtubules that extends down_from the_axon_and loops_throughout_the synaptic terminal._This microtubule loop_is structurally similar to_those found in_red_blood cells. Using 3D confocal fluorescence, block-face serial scanning electron microscopy, and transmission electron_microscopy_we fully_characterized_this_structure. We found that this_microtubule structure associates with"}
{"text": " This study has been accepted for publication in the Biophysical Journal (due out in October 2005) and will be highlighted on the journals cover. A second manuscript, evaluating how quantitative spectral imaging is for discriminating proteins labeled with either blue (CFP) or yellow (YFP) variants of green fluorescent protein (GFP)", "synonym_substitution": "This study has been accepted for publication in the Biophysical Journal (due out in October 2005) and will be foreground on the daybook cover. A second manuscript, evaluating how quantitative spectral imagination is for discriminating proteins labeled with either gloomy (CFP) or yellow (YFP) variants of fleeceable fluorescent protein (GFP )", "butter_fingers": " Thls study has been accepttd for publicatiou in thx Biophgsical Juurnal (due out in October 2005) aid wull bt highlighted on thd journald cover. Q serond manuscript, xbaluatiky how euancivative spectral imaging iv for discrimitagiug proteins labeled with either blue (CFP) or yfllow (YFP) variwnts jf gdvek fluorescent protein (GFP)", "random_deletion": "This study has been accepted for publication Biophysical (due out October 2005) and journals A second manuscript, how quantitative spectral is for discriminating proteins labeled with blue (CFP) or yellow (YFP) variants of green fluorescent protein (GFP)", "change_char_case": " This study has been accepted fOr publicatIon in The bioPhYsicAl JoUrnal (due out in OCTobeR 2005) and will be highlighted oN the jOuRNals COvEr. A seCond manUScRIPt, eVaLuAtiNg HOw QuantItaTive speCtral imagiNg iS fOr discriminaTInG proteins lAbeLed with eitheR blUe (CFP) oR yEllOW (YFP) vAriAnts oF green FLuoresCent proteIn (gfP)", "whitespace_perturbation": " This study has been accep ted for pu blica tio n i ntheBiop hysical Journa l  (du e out in October 2005)  andwi l l be hi ghlig hted on th e jou rn al s c ov e r.  A se con d manus cript, eva lua ti ng how quant i ta tive spect ral  imaging isfor  discr im ina t ing p rot einslabele d  witheither bl ue (CFP)o r yello w (Y FP)variants of green fl u orescent prote in (GF P) ", "underscore_trick": " This_study has_been accepted for publication_in the_Biophysical_Journal (due_out_in October 2005)_and will be_highlighted on the journals_cover. A second_manuscript,_evaluating how quantitative spectral imaging is for discriminating proteins labeled with either blue (CFP)_or_yellow (YFP)_variants_of_green fluorescent protein (GFP)"}
{"text": " strength of the clutch determines range of ECM stiffness cells are able to sense to mediate durotaxis. Using high-resolution traction force microscopy on polyacrylamide ECMs of varying stiffnesses, we found that the mechanical behavior of the integrin-actin interface at FA exhibited ECM stiffness-dependent switching between a load-and-", "synonym_substitution": "strength of the clutch determines range of ECM stiffness cells are able to feel to intercede durotaxis. Using high - settlement grip force microscopy on polyacrylamide ECMs of varying severity, we found that the mechanical behavior of the integrin - actin interface at FA exhibit ECM stiffness - dependent switching between a warhead - and-", "butter_fingers": " stgength of the clutch dettrmines range of GCN stifhness cslls are able to sense to mediate ducotazis. Uwing high-resolution trxction fogce microwcopb on polyacrylammse ECMs of vadning vviffnesses, we fpund that dhe mechanical bdhcvior of the integrin-actin interface at FA rxjibited ECM styffntss-qepehdent switching between a load-and-", "random_deletion": "strength of the clutch determines range of cells able to to mediate durotaxis. on ECMs of varying we found that mechanical behavior of the integrin-actin interface FA exhibited ECM stiffness-dependent switching between a load-and-", "change_char_case": " strength of the clutch determInes range oF ECM sTifFneSs CellS are Able to sense to mEDiatE durotaxis. Using high-resOlutiOn TRactIOn Force MicroscOPy ON PolYaCrYlaMiDE EcMs of VarYing stiFfnesses, we FouNd That the mechaNIcAl behavior Of tHe integrin-acTin InterfAcE at fa exhiBitEd ECM StiffnESs-depeNdent switChINg betwEEn a load-AND-", "whitespace_perturbation": " strength of the clutch de termines r angeofECM  s tiff ness  cells are abl e  tosense to mediate durot axis.  U s ingh ig h-res olution tr a c tio nfo rce  m i cr oscop y o n polya crylamideECM sof varying s t if fnesses, w e f ound that th e m echani ca l b e havio r o f the  integ r in-act in interf ac e  at FA exhibit e d  E CM s tiffness-dependen t  s w itching betwee n a lo ad - an d - ", "underscore_trick": " strength_of the_clutch determines range of_ECM stiffness_cells_are able_to_sense to mediate_durotaxis. Using high-resolution_traction force microscopy on_polyacrylamide ECMs of_varying_stiffnesses, we found that the mechanical behavior of the integrin-actin interface at FA exhibited_ECM_stiffness-dependent switching_between_a_load-and-"}
{"text": " clinical and laboratory manifestations of the diseases are being assessed. A treatment protocol to assess the role of a novel long acting IL-1 inhibitor XOMA 052 has been approved by the IRB and is expected to start recruitment soon. UNDIFFERENTIATED DISEASE We have accumulated a number of patients who have", "synonym_substitution": "clinical and laboratory manifestations of the diseases are being assessed. A discussion protocol to measure the role of a novel retentive act IL-1 inhibitor XOMA 052 has been approved by the IRB and is expected to begin recruitment soon. UNDIFFERENTIATED DISEASE We have accumulate a number of patient who have", "butter_fingers": " cllnical and laboratory makifestations of jhw diseeses ars being xssessed. A treatment protocop ro aswess the role of a novdl long abting IL-1 unhiuitor XOMA 052 has usen appvjved ny thz MRB and is expegted to stast recruitment suou. UNDIFFERENTIATED DISEASE We have ascumulayef a number of katiemes wgo have", "random_deletion": "clinical and laboratory manifestations of the diseases assessed. treatment protocol assess the role IL-1 XOMA 052 has approved by the and is expected to start recruitment UNDIFFERENTIATED DISEASE We have accumulated a number of patients who have", "change_char_case": " clinical and laboratory maniFestations Of the DisEasEs Are bEing Assessed. A treatMEnt pRotocol to assess the role Of a noVeL Long ACtIng IL-1 InhibitOR Xoma 052 haS bEeN apPrOVeD by thE IRb and is eXpected to sTarT rEcruitment soON. UnDIFFERENTiATeD DISEASE We hAve AccumuLaTed A NumbeR of PatieNts who HAve", "whitespace_perturbation": " clinical and laboratory m anifestati ons o f t hedi seas es a re being asses s ed.A treatment protocol t o ass es s  the ro le of  a nove l  l o n g a ct in g I L- 1  i nhibi tor  XOMA 0 52 has bee n a pp roved by the IR B and is e xpe cted to star t r ecruit me nts oon.UND IFFER ENTIAT E D DISE ASE We ha ve accumu l ated an u mb er o f patients who ha v e", "underscore_trick": " clinical_and laboratory_manifestations of the diseases_are being_assessed._A treatment_protocol_to assess the_role of a_novel long acting IL-1_inhibitor XOMA 052_has_been approved by the IRB and is expected to start recruitment soon. UNDIFFERENTIATED DISEASE_We_have accumulated_a_number_of patients who have"}
{"text": ") fused with the diphtheria toxin fragment 390 (DT390) is underway. This recombinant toxin fragment is safer because it lacks the native toxin-binding domain, therefore, preventing internalization of toxin in off-target cells. The resulting scFv-DT390 (69.55 kDa) and svF", "synonym_substitution": ") fused with the diphtheria toxin fragment 390 (DT390) is underway. This recombinant toxin fragment is safe because it miss the native toxin - binding domain, consequently, preventing internalization of toxin in off - aim cells. The resulting scFv - DT390 (69.55 kDa) and svF", "butter_fingers": ") fuded with the diphtheria uoxin fragment 390 (DJ390) us undxrway. Tgis recoobinant toxin fragment is saher vecauwe it lacks the native toxin-binfing domqin, uherefore, preventmhg intevualizzbion mh toxin in off-tsrget cellv. The resultinc rcYv-DT390 (69.55 kDa) and svF", "random_deletion": ") fused with the diphtheria toxin fragment is This recombinant fragment is safer toxin-binding therefore, preventing internalization toxin in off-target The resulting scFv-DT390 (69.55 kDa) and", "change_char_case": ") fused with the diphtheria toxIn fragment 390 (dT390) is uNdeRwaY. THis rEcomBinant toxin fraGMent Is safer because it lacks tHe natIvE ToxiN-BiNding Domain, tHErEFOre, PrEvEntInG InTernaLizAtion of Toxin in off-TarGeT cells. The resULtIng scFv-DT390 (69.55 kda) aNd svF", "whitespace_perturbation": ") fused with the diphtheri a toxin fr agmen t 3 90(D T390 ) is  underway. Thi s  rec ombinant toxin fragmen t issa f er b e ca use i t lacks th e nat iv etox in - bi nding  do main, t herefore,pre ve nting intern a li zation oftox in in off-ta rge t cell s.  Th e  resu lti ng sc Fv-DT3 9 0 (69. 55 kDa) a nd svF", "underscore_trick": ") fused_with the_diphtheria toxin fragment 390_(DT390) is_underway._This recombinant_toxin_fragment is safer_because it lacks_the native toxin-binding domain,_therefore, preventing internalization_of_toxin in off-target cells. The resulting scFv-DT390 (69.55 kDa) and svF"}
{"text": " 7 years. Third trimester serum was analyzed for PCBs in 1997-1999 for 730 women selected at random and for an additional 153 women whose children had either a low or high IQ score. The PCB-IQ association was examined while adjusting for study center, maternal age, race, serum lipids, parity, socioeconomic status", "synonym_substitution": "7 years. Third trimester serum was analyzed for PCBs in 1997 - 1999 for 730 women selected at random and for an extra 153 charwoman whose children had either a depleted or gamey IQ score. The PCB - IQ affiliation was examined while adjusting for study center field, maternal age, raceway, serum lipids, parity, socioeconomic condition", "butter_fingers": " 7 yfars. Third trimester sermm was analyzed yir PCBv in 1997-1999 ror 730 womdn selected at random and foc an addiuponal 153 women whose chkldren haf either a liq or high MS score. The PDN-IQ avwociation was gxamined whine adjusting fmr scudy center, maternal age, race, serum jipids, lagity, socioeconjmic ftaths", "random_deletion": "7 years. Third trimester serum was analyzed in for 730 selected at random women children had either low or high score. The PCB-IQ association was examined adjusting for study center, maternal age, race, serum lipids, parity, socioeconomic status", "change_char_case": " 7 years. Third trimester serum wAs analyzed For PCbs iN 1997-1999 foR 730 wOmen SeleCted at random anD For aN additional 153 women whose cHildrEn HAd eiTHeR a low Or high Iq ScORE. ThE PcB-iQ aSsOCiAtion Was ExamineD while adjuStiNg For study centER, mAternal age, RacE, serum lipids, ParIty, socIoEcoNOmic sTatUs", "whitespace_perturbation": " 7 years. Third trimesterserum wasanaly zed  fo rPCBs  in1997-1999 for7 30 w omen selected at rando m and  f o r an ad ditio nal 153 wo m e n w ho se  ch il d re n had  ei ther alow or hig h I Qscore. The P C B- IQ associa tio n was examin edwhilead jus t ing f orstudy  cente r , mate rnal age,  r a ce, se r um lipi d s ,pari ty, socioeconomic st a tus", "underscore_trick": " 7_years. Third_trimester serum was analyzed_for PCBs_in_1997-1999 for_730_women selected at_random and for_an additional 153 women_whose children had_either_a low or high IQ score. The PCB-IQ association was examined while adjusting for_study_center, maternal_age,_race,_serum lipids, parity, socioeconomic status"}
{"text": " family history based risk feedback motivates family communications about common, complex diseases and the development of cooperative strategies, such as encouragement to screen, to address this risk. Within the current reporting period, we have published three manuscripts from this project, two are under review, and two are in preparation. Based on results from Project RAM", "synonym_substitution": "family history based risk feedback motivates syndicate communication about common, complex diseases and the development of accommodative strategies, such as encouragement to shield, to cover this risk. Within the current reporting period, we have published three manuscripts from this undertaking, two are under review, and two are in preparation. Based on results from Project RAM", "butter_fingers": " falily history based risk needback motivatgs familb commuhicationr about common, complex diseadew and the development of couperative strategues, wych as encouragemekc to agreen, vo address this risk. Withhn the current rdplrting period, we have published thrqe manuxcgipts from thif prptect, nwi are under review, and two ars in prtparation. Based on results from Project RAM", "random_deletion": "family history based risk feedback motivates family common, diseases and development of cooperative screen, address this risk. the current reporting we have published three manuscripts from project, two are under review, and two are in preparation. Based on results Project RAM", "change_char_case": " family history based risk feeDback motivAtes fAmiLy cOmMuniCatiOns about common, COmplEx diseases and the develoPment Of COopeRAtIve stRategieS, SuCH As eNcOuRagEmENt To scrEen, To addreSs this risk. witHiN the current rEPoRting perioD, we Have publisheD thRee manUsCriPTs froM thIs proJect, twO Are undEr review, aNd TWo are iN PreparaTIOn. baseD on results from ProJEcT rAM", "whitespace_perturbation": " family history based risk  feedbackmotiv ate s f am ilycomm unications abo u t co mmon, complex diseases  andth e  dev e lo pment  of coo p er a t ive  s tr ate gi e s,  such  as  encour agement to  sc re en, to addre s sthis risk.  Wi thin the cur ren t repo rt ing perio d,we ha ve pub l ishedthree man us c riptsf rom thi s pr ojec t, two are underr ev i ew, and two ar e in p re p ar a t ion . B ased on re su lts f r om Proj e ct R A M", "underscore_trick": " family_history based_risk feedback motivates family_communications about_common,_complex diseases_and_the development of_cooperative strategies, such_as encouragement to screen,_to address this_risk._Within the current reporting period, we have published three manuscripts from this project, two_are_under review,_and_two_are in preparation. Based on_results from Project RAM"}
{"text": "existing chronic helminth infection on susceptibility to mycobacteria, on modulating the response to aeroallergens, and potentially to HIV and malaria. Specifically, we have recently demonstrated that coincident filarial infections profoundly alter the pro-inflammatory and Th1/Th17 responses to malarial antigens (in filarial/", "synonym_substitution": "existing chronic helminth infection on susceptibility to mycobacteria, on modulating the response to aeroallergens, and potentially to HIV and malaria. Specifically, we have recently attest that coincident filarial infection profoundly alter the pro - inflammatory and Th1 / Th17 responses to malarial antigen (in filarial/", "butter_fingers": "exidting chronic helminth ikfection on suscgpribilivy to mgcobactefia, on modulating the responde to atgoallergens, and potengially to HIV and maleria. Specificallb, we havc recsktly benonstrated thaj coincident filarial infewtkous profoundly alter the pro-inflammatjry and Tj1/Th17 responses jo makwriam antigens (in filarial/", "random_deletion": "existing chronic helminth infection on susceptibility to modulating response to and potentially to have demonstrated that coincident infections profoundly alter pro-inflammatory and Th1/Th17 responses to malarial (in filarial/", "change_char_case": "existing chronic helminth inFection on sUscepTibIliTy To myCobaCteria, on modulaTIng tHe response to aeroallergEns, anD pOTentIAlLy to HiV and maLArIA. speCiFiCalLy, WE hAve reCenTly demoNstrated thAt cOiNcident filarIAl Infections ProFoundly alter The Pro-infLaMmaTOry anD Th1/th17 resPonses TO malarIal antigeNs (IN filarIAl/", "whitespace_perturbation": "existing chronic helminthinfectionon su sce pti bi lity  tomycobacteria,o n mo dulating the responseto ae ro a ller g en s, an d poten t ia l l y t oHI V a nd ma laria . S pecific ally, we h ave  r ecently demo n st rated that  co incident fil ari al inf ec tio n s pro fou ndlyaltert he pro -inflamma to r y andT h1/Th17 r es pons es to malarial an t ig e ns (in filaria l/", "underscore_trick": "existing chronic_helminth infection_on susceptibility to mycobacteria,_on modulating_the_response to_aeroallergens,_and potentially to_HIV and malaria._Specifically, we have recently_demonstrated that coincident_filarial_infections profoundly alter the pro-inflammatory and Th1/Th17 responses to malarial antigens (in filarial/"}
{"text": " could give important insights into the mechanisms of SAMHD1 function and/or regulation. APOBEC3G/Vif: In FY12 we initiated a project studying the role of a newly identified host factor, CBF, in the control of APOBEC3G by Vif. Recent studies indicate that the", "synonym_substitution": "could give important insights into the mechanisms of SAMHD1 affair and/or rule. APOBEC3G / Vif: In FY12 we initiated a project study the character of a newly identified host gene, CBF, in the command of APOBEC3 G by Vif. Recent study indicate that the", "butter_fingers": " cokld give important insigmts into the meckqnisms of SAJHD1 funcgion and/or regulation. APOBEC3J/Vif: In FT12 we initiated a projezt studyijg the rile id a newly msentificb hosf faccoc, CBF, in the coktrol of APMBEC3G by Vif. Racdnc studies indicate that the", "random_deletion": "could give important insights into the mechanisms function regulation. APOBEC3G/Vif: FY12 we initiated of newly identified host CBF, in the of APOBEC3G by Vif. Recent studies that the", "change_char_case": " could give important insightS into the meChaniSms Of SaMhD1 fuNctiOn and/or regulatIOn. APoBEC3G/Vif: In FY12 we initiateD a proJeCT stuDYiNg the Role of a NEwLY IdeNtIfIed HoST fActor, cBF, In the coNtrol of APObEC3g bY Vif. Recent stUDiEs indicate ThaT the", "whitespace_perturbation": " could give important insi ghts intothe m ech ani sm s of  SAM HD1 function a n d/or  regulation. APOBEC3G/ Vif:In FY12 we  init iated a pr o j ect  s tu dyi ng th e rol e o f a new ly identif ied  h ost factor,C BF , in the c ont rol of APOBE C3G  by Vi f.  Re c ent s tud ies i ndicat e  thatthe", "underscore_trick": " could_give important_insights into the mechanisms_of SAMHD1_function_and/or regulation._APOBEC3G/Vif:_In FY12 we_initiated a project_studying the role of_a newly identified_host_factor, CBF, in the control of APOBEC3G by Vif. Recent studies indicate that the"}
{"text": " age-matched controls. We believe that the lower titers in the HbAS children may result from their lower incidence of infection and we are analyzing a study of asymptomatic parasitemia in these children. During the past year we have followed these children into a new transmission season and shown that, surprisingly, their IgG levels to specific", "synonym_substitution": "age - matched controls. We believe that the low titer in the HbAS children may result from their low incidence of contagion and we are analyzing a study of asymptomatic parasitemia in these children. During the past class we have trace these children into a fresh transmission season and shown that, amazingly, their IgG levels to specific", "butter_fingers": " agf-matched controls. We belleve that the locwr titxrs in fhe HbAS children may result from thxir oower incidence of infectiov and we wre analtzinj a study of asymptomatig parzditekma in these chikdren. Duritg the past yedr wz have followed these children into w new ttajsmission seasjn amq shkwn that, surprisingly, their IgG lebels to specific", "random_deletion": "age-matched controls. We believe that the lower the children may from their lower are a study of parasitemia in these During the past year we have these children into a new transmission season and shown that, surprisingly, their IgG to specific", "change_char_case": " age-matched controls. We belieVe that the lOwer tIteRs iN tHe HbaS chIldren may resulT From Their lower incidence of iNfectIoN And wE ArE analYzing a sTUdY OF asYmPtOmaTiC PaRasitEmiA in thesE children. DUriNg The past year wE HaVe followed TheSe children inTo a New traNsMisSIon seAsoN and sHown thAT, surprIsingly, thEiR igG levELs to speCIFiC", "whitespace_perturbation": " age-matched controls. Webelieve th at th e l owe rtite rs i n the HbAS chi l dren  may result from their  lowe ri ncid e nc e ofinfecti o na n d w ear e a na l yz ing a  st udy ofasymptomat icpa rasitemia in th ese childr en.  During thepas t year  w e h a ve fo llo wed t hese c h ildren  into a n ew transm i ssion s e a so n an d shown that, sur p ri s ingly, their I gG lev el s  t o spe cif ic", "underscore_trick": " age-matched_controls. We_believe that the lower_titers in_the_HbAS children_may_result from their_lower incidence of_infection and we are_analyzing a study_of_asymptomatic parasitemia in these children. During the past year we have followed these children_into_a new_transmission_season_and shown that, surprisingly, their_IgG levels to specific"}
{"text": " is one of the main regulators. We hypothesized that Rac1 may regulate myosin II minifilament assembly dynamics during cell migration via downstream regulation of PKC and Ser 1916 phosphorylation. To test this, we analyzed the effects of Rac1 activation on the phosphorylation and dynamics of myosin IIA in U2OS cells. We found", "synonym_substitution": "is one of the main regulators. We hypothesized that Rac1 may regulate myosin II minifilament fabrication moral force during cell migration via downstream regulation of PKC and Ser 1916 phosphorylation. To screen this, we analyze the effects of Rac1 activation on the phosphorylation and moral force of myosin IIA in U2OS cells. We found", "butter_fingers": " is one of the main regulaturs. We hypothesnzed thet Rac1 jay reguuate myosin II minifilament essenbly eynamics during cell mkgration nia downsrrean regulatioi of PKC and Ssv 1916 phmwphorylation. Tp test thiv, we analyzed dhd zffects of Rac1 activation on the phofphorylstlon and dynamiss og myoapn IIA in U2OS cells. We found", "random_deletion": "is one of the main regulators. We Rac1 regulate myosin minifilament assembly dynamics regulation PKC and Ser phosphorylation. To test we analyzed the effects of Rac1 on the phosphorylation and dynamics of myosin IIA in U2OS cells. We found", "change_char_case": " is one of the main regulators. WE hypothesiZed thAt RAc1 mAy ReguLate Myosin II minifiLAmenT assembly dynamics durinG cell MiGRatiON vIa dowNstream REgULAtiOn Of pKC AnD seR 1916 phosPhoRylatioN. To test thiS, we AnAlyzed the effECtS of Rac1 actiVatIon on the phosPhoRylatiOn And DYnamiCs oF myosIn IIA iN u2OS celLs. We found", "whitespace_perturbation": " is one of the main regula tors. We h ypoth esi zed  t hatRac1  may regulatem yosi n II minifilament asse mblydy n amic s  d uring  cell m i gr a t ion  v ia  do wn s tr eam r egu lationof PKC and  Se r1916 phospho r yl ation. Totes t this, we a nal yzed t he  ef f ectsofRac1activa t ion on  the phos ph o rylati o n and d y n am icsof myosin IIA inU 2O S  cells. We fou nd", "underscore_trick": " is_one of_the main regulators. We_hypothesized that_Rac1_may regulate_myosin_II minifilament assembly_dynamics during cell_migration via downstream regulation_of PKC and_Ser_1916 phosphorylation. To test this, we analyzed the effects of Rac1 activation on the_phosphorylation_and dynamics_of_myosin_IIA in U2OS cells. We_found"}
{"text": " These studies may help lead to community studies examining if interrupting sedentary behavior is a promising prevention strategy for reducing cardiometabolic risk in children. Investigations concentrating on binge eating behaviors in children suggest that such behaviors are also associated with adiposity in children and predict future weight gain in children at-risk for overweight. The", "synonym_substitution": "These studies may help lead to community report probe if interrupting sedentary behavior is a promising prevention scheme for reducing cardiometabolic risk in children. probe concentrating on binge eat behaviors in children indicate that such behaviors are also consociate with adiposity in children and predict future weight gain in children at - hazard for overweight. The", "butter_fingers": " Thfse studies may help leaa to community studies examihing if knterrupting sedentary behavmor us a kgomising prevention sgrategy flr reducung rardiometabolic cjsk in gkildrsk. Invzsvigations concektrating on binge eating tefariors in children suggest that such fehaviots are also assosiattd rith adiposity in children and predict future weight gain on children at-risk for ovegweihht. The", "random_deletion": "These studies may help lead to community if sedentary behavior a promising prevention in Investigations concentrating on eating behaviors in suggest that such behaviors are also with adiposity in children and predict future weight gain in children at-risk for The", "change_char_case": " These studies may help lead to Community sTudieS exAmiNiNg if InteRrupting sedentARy beHavior is a promising prevEntioN sTRateGY fOr redUcing caRDiOMEtaBoLiC riSk IN cHildrEn. INvestigAtions concEntRaTing on binge eATiNg behaviorS in Children suggEst That suCh BehAViors Are Also aSsociaTEd with Adiposity In CHildreN And predICT fUturE weight gain in chilDReN At-risk for overwEight. THe", "whitespace_perturbation": " These studies may help le ad to comm unity  st udi es  exa mini ng if interrup t ingsedentary behavior isa pro mi s ingp re venti on stra t eg y for  r ed uci ng ca rdiom eta bolic r isk in chi ldr en . Investigat i on s concentr ati ng on bingeeat ing be ha vio r s inchi ldren  sugge s t that  such beh av i ors ar e  also a s s oc iate d with adiposityi nc hildren and pr edictfu t ur e wei ght  gain in c hi ldren at-risk fo r o ver w eight. The", "underscore_trick": " These_studies may_help lead to community_studies examining_if_interrupting sedentary_behavior_is a promising_prevention strategy for_reducing cardiometabolic risk in_children. Investigations concentrating_on_binge eating behaviors in children suggest that such behaviors are also associated with adiposity_in_children and_predict_future_weight gain in children at-risk_for overweight. The"}
{"text": " we demonstrated that a time related TGF-beta gene expression signature established in mouse primary hepatocytes successfully discriminated distinct subgroups of HCC. The TGF-beta positive cluster included two novel homogeneous groups of HCC associated with early and late TGF-beta signatures. Kaplan-Meier plots and logrank statistics indicated that patients with the late TGF-beta", "synonym_substitution": "we demonstrated that a time related TGF - beta gene expression touch prove in mouse primary hepatocytes successfully discriminated distinct subgroups of HCC. The TGF - beta plus cluster included two fresh homogeneous groups of HCC associated with early and late TGF - beta signature. Kaplan - Meier plots and logrank statistics argue that patients with the late TGF - beta", "butter_fingers": " we demonstrated that a timt related TGF-beta gene eepressikn signagure established in mouse prmmart hepqtocytes successfully aiscriminwted disrincu subgroups of HCR. The TGN-yeta llsitnvx cluster incluced two noeel homogeneouv erlups of HCC associated with early agd late THF-beta signatutes. Ks[lan-Jvitr plots and logrank statistics ihdicatev that patients with the late TGF-beta", "random_deletion": "we demonstrated that a time related TGF-beta signature in mouse hepatocytes successfully discriminated TGF-beta cluster included two homogeneous groups of associated with early and late TGF-beta Kaplan-Meier plots and logrank statistics indicated that patients with the late TGF-beta", "change_char_case": " we demonstrated that a time reLated TGF-beTa genE exPreSsIon sIgnaTure establisheD In moUse primary hepatocytes sUccesSfULly dIScRiminAted disTInCT SubGrOuPs oF Hcc. THe TGF-BetA positiVe cluster iNclUdEd two novel hoMOgEneous grouPs oF HCC associatEd wIth earLy And LAte TGf-beTa sigNatureS. kaplan-meier plotS aND lograNK statisTICs IndiCated that patients WItH The late TGF-beta", "whitespace_perturbation": " we demonstrated that a ti me related  TGF- bet a g en e ex pres sion signature esta blished in mouse prima ry he pa t ocyt e ssucce ssfully di s c rim in at eddi s ti nct s ubg roups o f HCC. The  TG F- beta positiv e  c luster inc lud ed two novel  ho mogene ou s g r oupsofHCC a ssocia t ed wit h early a nd late T G F-betas i gn atur es. Kaplan-Meierp lo t s and logrankstatis ti c si n dic ate d that pat ie nts w i th thel at e T GF- b eta", "underscore_trick": " we_demonstrated that_a time related TGF-beta_gene expression_signature_established in_mouse_primary hepatocytes successfully_discriminated distinct subgroups_of HCC. The TGF-beta_positive cluster included_two_novel homogeneous groups of HCC associated with early and late TGF-beta signatures. Kaplan-Meier plots_and_logrank statistics_indicated_that_patients with the late TGF-beta"}
{"text": " of the Biostatistics group to develop a computerized model of the MFA which allows us to ask questions about assay variables and predict outcomes. In addition, it allows us to test sexual stage vaccine candidates for transmission blocking activity and obtain confidence limits. We have constructed and characterized a new set of mouse monoclonal antibodies to the full", "synonym_substitution": "of the Biostatistics group to develop a computerized model of the MFA which allows us to ask question about assay variable star and predict outcomes. In addition, it permit us to test sexual phase vaccine candidates for transmission blocking action and obtain confidence limit. We have constructed and characterized a raw hardening of mouse monoclonal antibodies to the full", "butter_fingers": " of the Biostatistics group to develop a computermzed mosel of tfe MFA which allows us to asn wuestuons about assay variacles and iredict oytconws. In addivjon, it allows ms to vest sexual stane vaccine wandidates for tfausmission blocking activity and obtayn confodfnce limits. We havt cjnstdlcued and characterized a new set or mouse monoclonal amtibodies to the full", "random_deletion": "of the Biostatistics group to develop a of MFA which us to ask predict In addition, it us to test stage vaccine candidates for transmission blocking and obtain confidence limits. We have constructed and characterized a new set of monoclonal antibodies to the full", "change_char_case": " of the Biostatistics group to Develop a coMputeRizEd mOdEl of The MfA which allows uS To asK questions about assay vaRiablEs ANd prEDiCt outComes. In ADdITIon, It AlLowS uS To Test sExuAl stage Vaccine canDidAtEs for transmiSSiOn blocking ActIvity and obtaIn cOnfideNcE liMIts. We HavE consTructeD And chaRacterizeD a NEw set oF Mouse moNOClOnal Antibodies to the fuLL", "whitespace_perturbation": " of the Biostatistics grou p to devel op acom put er ized  mod el of the MFAw hich  allows us to ask ques tions  a b outa ss ay va riables an d pre di ct  ou tc o me s. In  ad dition,  it allows  us  t o test sexua l  s tage vacci necandidates f ortransm is sio n  bloc kin g act ivitya nd obt ain confi de n ce lim i ts. Weh a ve  con structed and char a ct e rized a new se t of m ou s em o noc lon al antibod ie s tot he full ", "underscore_trick": " of_the Biostatistics_group to develop a_computerized model_of_the MFA_which_allows us to_ask questions about_assay variables and predict_outcomes. In addition,_it_allows us to test sexual stage vaccine candidates for transmission blocking activity and obtain_confidence_limits. We_have_constructed_and characterized a new set_of mouse monoclonal antibodies to_the full"}
{"text": " mice that have germline null mutations in EpCAM. Diseases caused by retroviruses such as AIDS and leukemia have intensified the need to understand the mechanisms of retrovirus replication. Our primary objectives are to understand how reverse transcription of viral mRNA occurs and how the cDNA products are integrated into the genome of infected cells. Owing to", "synonym_substitution": "mice that have germline null mutations in EpCAM. Diseases caused by retrovirus such as AIDS and leukemia have intensify the need to understand the mechanism of retrovirus rejoinder. Our primary objectives are to sympathize how reverse transcription of viral mRNA happen and how the cDNA products are integrate into the genome of infected cells. owe to", "butter_fingers": " mife that have germline nuul mutations in EpCAM. Viseasea caused by retroviruses such as AIDD qnd ltlkemia have intensifidd the nevd to undwrstend the mechanisms of rebxovirhd re'lmcation. Our prikary objecdives are to utddrdtand how reverse transcription of diral mTNW occurs and hjw tnq cDHA products are integrated into ths genomt of infected cellx. Owing to", "random_deletion": "mice that have germline null mutations in caused retroviruses such AIDS and leukemia understand mechanisms of retrovirus Our primary objectives to understand how reverse transcription of mRNA occurs and how the cDNA products are integrated into the genome of cells. Owing to", "change_char_case": " mice that have germline null mUtations in epCAM. disEasEs CausEd by Retroviruses suCH as AiDS and leukemia have inteNsifiEd THe neED tO undeRstand tHE mECHanIsMs Of rEtROvIrus rEplIcation. our primary ObjEcTives are to unDErStand how reVerSe transcriptIon Of viraL mrNA OCcurs And How thE cDNA pROducts Are integrAtED into tHE genome OF InFectEd cells. Owing to", "whitespace_perturbation": " mice that have germline n ull mutati ons i n E pCA M.  Dis ease s caused by re t rovi ruses such as AIDS and  leuk em i a ha v einten sifiedt he n eed  t ound er s ta nd th e m echanis ms of retr ovi ru s replicatio n .Our primar y o bjectives ar e t o unde rs tan d  howrev ersetransc r iption  of viral  m R NA occ u rs andh o wthecDNA products are in t egrated into t he gen om e  o f inf ect ed cells.Ow ing t o ", "underscore_trick": " mice_that have_germline null mutations in_EpCAM. Diseases_caused_by retroviruses_such_as AIDS and_leukemia have intensified_the need to understand_the mechanisms of_retrovirus_replication. Our primary objectives are to understand how reverse transcription of viral mRNA occurs_and_how the_cDNA_products_are integrated into the genome_of infected cells. Owing to"}
{"text": " validate the Jun signature by analysis of enrichment of specific binding sites in the promoter regions of this subset of genes. A similar approach is currently used in JNK conditional knockout mice. We have previously reported that the gene expression profiles of HCC derived from c-Myc/Tgf&amp;#945;transgenic mice closely", "synonym_substitution": "validate the Jun signature by analysis of enrichment of specific binding sites in the showman region of this subset of genes. A similar overture is presently used in JNK conditional knockout mice. We have previously report that the gene expression profiles of HCC deduce from c - Myc / Tgf&amp;#945;transgenic mice closely", "butter_fingers": " vapidate the Jun signature by analysis of enrichkent or specifkc binding sites in the promltwr retions of this subset ow genes. A similar appcoach is currently used lu JNK gondiciinal knockout kice. We haee previously seooxted that the gene expression profilqs of HVC derived from s-Myc/Ugf&wmp;#945;tdansgenic mice closely", "random_deletion": "validate the Jun signature by analysis of specific sites in promoter regions of similar is currently used JNK conditional knockout We have previously reported that the expression profiles of HCC derived from c-Myc/Tgf&amp;#945;transgenic mice closely", "change_char_case": " validate the Jun signature by Analysis of EnricHmeNt oF sPeciFic bInding sites in tHE proMoter regions of this subsEt of gEnES. A siMIlAr appRoach is CUrRENtlY uSeD in jNk CoNditiOnaL knockoUt mice. We haVe pReViously reporTEd That the genE exPression profIleS of HCC DeRivED from C-MyC/Tgf&aMp;#945;tranSGenic mIce closelY", "whitespace_perturbation": " validate the Jun signatur e by analy sis o f e nri ch ment  ofspecific bindi n g si tes in the promoter re gions  o f  thi s  s ubset  of gen e s. A  si mi la r a pp r oa ch is  cu rrently  used in J NKco nditional kn o ck out mice.Wehave previou sly  repor te d t h at th e g ene e xpress i on pro files ofHC C  deriv e d fromc - My c/Tg f&amp;#945;transg e ni c  mice closely", "underscore_trick": " validate_the Jun_signature by analysis of_enrichment of_specific_binding sites_in_the promoter regions_of this subset_of genes. A similar_approach is currently_used_in JNK conditional knockout mice. We have previously reported that the gene expression profiles_of_HCC derived_from_c-Myc/Tgf&amp;#945;transgenic_mice closely"}
{"text": " signs and detectable EBOV challenge virus. Since HPIV3 is a common human pathogen and essentially all adults have a history of natural infection with HPIV3, it was important to determine whether previous infection with HPIV3 would restrict the replication and immunogenicity of the HPIV3 vector. In guinea pigs that were infected", "synonym_substitution": "signs and detectable EBOV challenge virus. Since HPIV3 is a common human pathogen and essentially all adults get a history of lifelike infection with HPIV3, it was important to settle whether former infection with HPIV3 would restrict the replication and immunogenicity of the HPIV3 vector. In wop pigs that were infected", "butter_fingers": " sihns and detectable EBOV ghallenge virus. Since H'IV3 is z common human pathogen and essentiaplt all adults have a history of naturwl infecrion qith HPIV3, mf was importahb to bevermine whether previous hnfection with HOIR3 would restrict the replication and immunobejicity of the RPIV3 dectkg. Ln guinea pigs that were infectes", "random_deletion": "signs and detectable EBOV challenge virus. Since a human pathogen essentially all adults infection HPIV3, it was to determine whether infection with HPIV3 would restrict the and immunogenicity of the HPIV3 vector. In guinea pigs that were infected", "change_char_case": " signs and detectable EBOV chaLlenge viruS. SincE HPiV3 iS a CommOn huMan pathogen and ESsenTially all adults have a hiStory Of NAturAL iNfectIon with hpIv3, IT waS iMpOrtAnT To DeterMinE whetheR previous iNfeCtIon with HPIV3 wOUlD restrict tHe rEplication anD imMunogeNiCitY Of the hPIv3 vectOr. In guINea pigS that were InFEcted", "whitespace_perturbation": " signs and detectable EBOV  challenge  viru s.Sin ce  HPI V3 i s a common hum a n pa thogen and essentially  allad u ltsh av e a h istoryo fn a tur al  i nfe ct i on  with  HP IV3, it  was impor tan tto determine wh ether prev iou s infectionwit h HPIV 3wou l d res tri ct th e repl i cation  and immu no g enicit y  of the H PI V3 v ector. In guineap ig s  that were inf ected", "underscore_trick": " signs_and detectable_EBOV challenge virus. Since_HPIV3 is_a_common human_pathogen_and essentially all_adults have a_history of natural infection_with HPIV3, it_was_important to determine whether previous infection with HPIV3 would restrict the replication and immunogenicity_of_the HPIV3_vector._In_guinea pigs that were infected"}
{"text": " has produced 6 domains of the VAR2CSA protein in recombinant E. coli and we have tested their recognition by antisera from Malian adults. Antibodies from multiparous Malian women but not men recognize some of these domains by ELISA. We have also standardized an opsonization assay using these IgGs and", "synonym_substitution": "has produced 6 domains of the VAR2CSA protein in recombinant E. coli and we have tested their recognition by antisera from Malian adult. Antibodies from multiparous Malian charwoman but not men recognize some of these domains by ELISA. We have besides standardized an opsonization assay using these IgGs and", "butter_fingers": " had produced 6 domains of tme VAR2CSA proteiu in rerombinaht E. colk and we have tested their rxcogbitiob by antisera from Malkan adultd. Antiboeies drom multi'zrous Malian slmen uut not men recpgnize soma of these domdivs by ELISA. We have also standardized an opspnlzation assay osing ehess IgGs and", "random_deletion": "has produced 6 domains of the VAR2CSA recombinant coli and have tested their adults. from multiparous Malian but not men some of these domains by ELISA. have also standardized an opsonization assay using these IgGs and", "change_char_case": " has produced 6 domains of the VAr2CSA proteiN in reComBinAnT E. coLi anD we have tested tHEir rEcognition by antisera frOm MalIaN AdulTS. ANtiboDies froM MuLTIpaRoUs malIaN WoMen buT noT men recOgnize some Of tHeSe domains by EliSa. We have alsO stAndardized an OpsOnizatIoN asSAy usiNg tHese IGGs and", "whitespace_perturbation": " has produced 6 domains of  the VAR2C SA pr ote inin  rec ombi nant E. coli a n d we  have tested their rec ognit io n  bya nt isera  from M a li a n  ad ul ts . A nt i bo diesfro m multi parous Mal ian  w omen but not me n recogniz e s ome of these  do mainsby  EL I SA. W e h ave a lso st a ndardi zed an op so n izatio n  assayu s in g th ese IgGs and", "underscore_trick": " has_produced 6_domains of the VAR2CSA_protein in_recombinant_E. coli_and_we have tested_their recognition by_antisera from Malian adults._Antibodies from multiparous_Malian_women but not men recognize some of these domains by ELISA. We have also_standardized_an opsonization_assay_using_these IgGs and"}
{"text": " and SIV Nef alleles in the context DNA transfection, single-cycle HIV infection or Nef protein transduction, although the downregulation was quite modest compared to that of CD4. We also show that both naturally truncated mutants of CXCR4 as in WHIMS or engineered truncated variants of CXCR1, CXCR2 and CXCR", "synonym_substitution": "and SIV Nef alleles in the context DNA transfection, single - cycle HIV contagion or Nef protein transduction, although the downregulation was quite minor compared to that of CD4. We also picture that both naturally truncate mutants of CXCR4 as in WHIMS or engineered truncate version of CXCR1, CXCR2 and CXCR", "butter_fingers": " anf SIV Nef alleles in the context DNA trcbsfectmon, sinfle-cycle HIV infection or Nef proteii trqnsduxtion, although the dowvregulatiln was qyite nodest com'zred to that kn CD4. Ce also show thaj both naturdlly truncated mjtcnts of CXCR4 as in WHIMS or engineerqd trunvahed variants os CXBR1, CXCD2 and CXCR", "random_deletion": "and SIV Nef alleles in the context single-cycle infection or protein transduction, although compared that of CD4. also show that naturally truncated mutants of CXCR4 as WHIMS or engineered truncated variants of CXCR1, CXCR2 and CXCR", "change_char_case": " and SIV Nef alleles in the contExt DNA tranSfectIon, SinGlE-cycLe HIv infection or NeF ProtEin transduction, althougH the dOwNReguLAtIon waS quite mODeST ComPaReD to ThAT oF CD4. We AlsO show thAt both natuRalLy Truncated mutANtS of CXCR4 as iN WHiMS or engineeRed TruncaTeD vaRIants Of CxCR1, CXcR2 and CxcR", "whitespace_perturbation": " and SIV Nef alleles in th e contextDNA t ran sfe ct ion,  sin gle-cycle HIVi nfec tion or Nef protein tr ansdu ct i on,a lt hough  the do w nr e g ula ti on  wa sq ui te mo des t compa red to tha t o fCD4. We also sh ow that bo thnaturally tr unc ated m ut ant s  of C XCR 4 asin WHI M S or e ngineered  t r uncate d  varian t s  o f CX CR1, CXCR2 and CX C R", "underscore_trick": " and_SIV Nef_alleles in the context_DNA transfection,_single-cycle_HIV infection_or_Nef protein transduction,_although the downregulation_was quite modest compared_to that of_CD4._We also show that both naturally truncated mutants of CXCR4 as in WHIMS or_engineered_truncated variants_of_CXCR1,_CXCR2 and CXCR"}
{"text": ", overwriting, and selective updating. A functionally coupled network consisting of midbrain regions were selectively engaged during wm updating when compared to both overwriting and maintenance. In both behavioral and neurophysiological terms, we revealed that selective updating was clearly parsed from maintenance and nonselective updating of information. Analysis also showed differential mid", "synonym_substitution": ", overwriting, and selective updating. A functionally coupled network consisting of midbrain region were selectively engage during wm updating when compare to both overwriting and alimony. In both behavioral and neurophysiological terms, we revealed that selective updating was distinctly parse from maintenance and nonselective updating of information. Analysis also showed differential mid", "butter_fingers": ", ovfrwriting, and selective mpdating. A functninally couplsd netwofk consisting of midbrain rejionw wert selectively engagdd during wm updaring qhen compacsd to both ovsvwritnnj and maintenange. In both tehavioral and nduxophysiological terms, we revealed thwt selevtlve updating wws ckqarlg parsed from maintenance and nonsslectivt updating of infotmation. Analysis also showfd dlfferential mid", "random_deletion": ", overwriting, and selective updating. A functionally consisting midbrain regions selectively engaged during both and maintenance. In behavioral and neurophysiological we revealed that selective updating was parsed from maintenance and nonselective updating of information. Analysis also showed differential mid", "change_char_case": ", overwriting, and selective upDating. A funCtionAllY coUpLed nEtwoRk consisting of MIdbrAin regions were selectivEly enGaGEd duRInG wm upDating wHEn COMpaReD tO boTh OVeRwritIng And mainTenance. In bOth BeHavioral and nEUrOphysiologIcaL terms, we reveAleD that sElEctIVe updAtiNg was ClearlY Parsed From maintEnANce and NOnselecTIVe UpdaTing of information. aNaLYsis also showed DifferEnTIaL MId", "whitespace_perturbation": ", overwriting, and selecti ve updatin g. Afun cti on ally  cou pled network c o nsis ting of midbrain regio ns we re sele c ti velyengaged du r i ngwm  u pda ti n gwhencom pared t o both ove rwr it ing and main t en ance. In b oth  behavioraland  neuro ph ysi o logic alterms , we r e vealed  that sel ec t ive up d ating w a s  c lear ly parsed from ma i nt e nance and nons electi ve up d a tin g o f informat io n. An a lysis a l so s h owe d  differential  mid", "underscore_trick": ", overwriting,_and selective_updating. A functionally coupled_network consisting_of_midbrain regions_were_selectively engaged during_wm updating when_compared to both overwriting_and maintenance. In_both_behavioral and neurophysiological terms, we revealed that selective updating was clearly parsed from maintenance_and_nonselective updating_of_information._Analysis also showed differential mid"}
{"text": " This showed that phosphorylation is critical to the Rac1-induced rapid assembly and turnover of myosin IIA minifilaments as well as to the focal adhesion association of myosin IIA. Thus, Rac1 acts as a master regulator of cell migration by coordinating actin assembly-mediated protrusion, adhesion, and actomyosin", "synonym_substitution": "This showed that phosphorylation is critical to the Rac1 - induced rapid assembly and turnover of myosin IIA minifilaments equally well as to the focal adhesiveness association of myosin IIA. Thus, Rac1 act as a overlord regulator of cell migration by align actin forum - mediated bulge, adhesiveness, and actomyosin", "butter_fingers": " Thls showed that phosphoryuation is critieql to vhe Rac1-jnduced fapid assembly and turnover lf myosun IIA minifilaments ar well as to the docao adhesion easociatljn or myovmn IIA. Thus, Rac1 acts as a master reguladof lf cell migration by coordinating astin asxelbly-mediated ptotruxyon, zdhesion, and actomyosin", "random_deletion": "This showed that phosphorylation is critical to rapid and turnover myosin IIA minifilaments focal association of myosin Thus, Rac1 acts a master regulator of cell migration coordinating actin assembly-mediated protrusion, adhesion, and actomyosin", "change_char_case": " This showed that phosphorylaTion is critIcal tO thE RaC1-iNducEd raPid assembly and TUrnoVer of myosin IIA minifilaMents As WEll aS To The foCal adheSIoN ASsoCiAtIon Of MYoSin IIa. ThUs, Rac1 acTs as a masteR reGuLator of cell mIGrAtion by cooRdiNating actin aSseMbly-meDiAteD ProtrUsiOn, adhEsion, aND actomYosin", "whitespace_perturbation": " This showed that phosphor ylation is  crit ica l t otheRac1 -induced rapid asse mbly and turnover of m yosin  I I A mi n if ilame nts asw el l asto  t hefo c al  adhe sio n assoc iation ofmyo si n IIA. Thus, Ra c1 acts as  amaster regul ato r of c el l m i grati onby co ordina t ing ac tin assem bl y -media t ed prot r u si on,adhesion, and act o my o sin", "underscore_trick": " This_showed that_phosphorylation is critical to_the Rac1-induced_rapid_assembly and_turnover_of myosin IIA_minifilaments as well_as to the focal_adhesion association of_myosin_IIA. Thus, Rac1 acts as a master regulator of cell migration by coordinating actin_assembly-mediated_protrusion, adhesion,_and_actomyosin"}
{"text": " have unique specializations and hold the second tier vendors to the same high level of quality assurance. This management strategy offers several advantages, not the least of which is that is minimizes the number of projects with which the SAIC-Frederick senior staff will need to interact so as not to lessen the assay development effort", "synonym_substitution": "have unique specializations and hold the second grade seller to the like high level of quality assurance. This management scheme offers several advantages, not the least of which is that is minimizes the act of projects with which the SAIC - Frederick senior staff will necessitate to interact so as not to lessen the assay exploitation effort", "butter_fingers": " hage unique specializationr and hold the second vier vehdors to the same high level of qualmty qssurqnce. This management sgrategy ovfers secerao advantages, not thc leaab of chmch is that is kinimizes dhe number of [rujzcts with which the SAIC-Frederick segior stsfv will need to inttrast sk as not to lessen the assay develkpment tffort", "random_deletion": "have unique specializations and hold the second to same high of quality assurance. advantages, the least of is that is the number of projects with which SAIC-Frederick senior staff will need to interact so as not to lessen the development effort", "change_char_case": " have unique specializations And hold the SeconD tiEr vEnDors To thE same high level OF quaLity assurance. This managEment StRAtegY OfFers sEveral aDVaNTAgeS, nOt The LeASt Of whiCh iS that is Minimizes tHe nUmBer of projectS WiTh which the sAIc-Frederick seNioR staff WiLl nEEd to iNteRact sO as not TO lesseN the assay DeVElopmeNT effort", "whitespace_perturbation": " have unique specializatio ns and hol d the  se con dtier  ven dors to the sa m e hi gh level of quality as suran ce .  Thi s  m anage ment st r at e g y o ff er s s ev e ra l adv ant ages, n ot the lea stof  which is th a tis minimiz esthe number o f p roject swit h  whic h t he SA IC-Fre d ericksenior st af f  willn eed toi n te ract  so as not to les s en the assay deve lopmen te ff o r t", "underscore_trick": " have_unique specializations_and hold the second_tier vendors_to_the same_high_level of quality_assurance. This management_strategy offers several advantages,_not the least_of_which is that is minimizes the number of projects with which the SAIC-Frederick senior_staff_will need_to_interact_so as not to lessen_the assay development effort"}
{"text": "asiveness) properties. Based on these considerations, we hypothesized that the TGF-beta gene expression signature established under well-controlled experimental conditions in vitro may contain gene sets characteristic of both tumor suppressive and oncogenic properties and thus be relevant for the molecular classification of tumors (69). Using the comparative functional genomics approach,", "synonym_substitution": "asiveness) properties. Based on these considerations, we hypothesized that the TGF - beta gene formula touch established under well - controlled experimental conditions in vitro may hold gene sets characteristic of both tumor suppressive and oncogenic properties and therefore be relevant for the molecular classification of tumors (69). Using the relative running genomics approach,", "butter_fingers": "asigeness) properties. Based un these considgrqtions, we hylothesizdd that the TGF-beta gene expcessuon sugnature established uvder well-bontrollee exkerimental conditmkns in yntro jwy cmitain gene sets characterhstic of both duoox suppressive and oncogenic propertiqs and yhks be relevant for ehe jolecular classification of tumors (69). Using the comparatove functional genomics aporoafh,", "random_deletion": "asiveness) properties. Based on these considerations, we the gene expression established under well-controlled contain sets characteristic of tumor suppressive and properties and thus be relevant for molecular classification of tumors (69). Using the comparative functional genomics approach,", "change_char_case": "asiveness) properties. Based oN these consIderaTioNs, wE hYpotHesiZed that the TGF-bETa geNe expression signature eStablIsHEd unDEr Well-cOntrollED eXPEriMeNtAl cOnDItIons iN viTro may cOntain gene SetS cHaracteristiC Of Both tumor sUppRessive and onCogEnic prOpErtIEs and ThuS be reLevant FOr the mOlecular cLaSSificaTIon of tuMORs (69). usinG the comparative fuNCtIOnal genomics apProach,", "whitespace_perturbation": "asiveness) properties. Bas ed on thes e con sid era ti ons,  wehypothesized t h at t he TGF-beta gene expre ssion  s i gnat u re  esta blished un d e r w el l- con tr o ll ed ex per imental  condition s i nvitro may co n ta in gene se tscharacterist icof bot htum o r sup pre ssive  and o n cogeni c propert ie s  and t h us be r e l ev antfor the molecular cl a ssification of  tumor s( 69 ) .  Us ing  the compa ra tivef unction a lg e n omi c s approach,", "underscore_trick": "asiveness) properties._Based on_these considerations, we hypothesized_that the_TGF-beta_gene expression_signature_established under well-controlled_experimental conditions in_vitro may contain gene_sets characteristic of_both_tumor suppressive and oncogenic properties and thus be relevant for the molecular classification of_tumors_(69). Using_the_comparative_functional genomics approach,"}
{"text": " anakinra had already significant hearing loss at baseline and more persistent enhancement on MRI. Low grade leptomeningeal inflammation was seen in up to 50% of patients at 3 years but dropped further at 5years. Although no new bone lesions occurred with anakinra treatment, preexisting bony lesions continued to expand on", "synonym_substitution": "anakinra had already significant hearing loss at service line and more haunting enhancement on MRI. Low grade leptomeningeal excitement was understand in up to 50% of patients at 3 years but drop further at 5years. Although no new bone lesion occurred with anakinra treatment, preexist bony lesions continued to expand on", "butter_fingers": " anwkinra had already signinicant hearing loss at uaselins and mofe persistent enhancement on MEI. Loq grade leptomeningeal inflammanion was ween un up to 50% of patiekcs at 3 yeaxs but dropped forther at 5yedrs. Although nm vec bone lesions occurred with anakinrw treatkejt, preexisting bonj jesikns continued to expand on", "random_deletion": "anakinra had already significant hearing loss at more enhancement on Low grade leptomeningeal to of patients at years but dropped at 5years. Although no new bone occurred with anakinra treatment, preexisting bony lesions continued to expand on", "change_char_case": " anakinra had already signifiCant hearinG loss At bAseLiNe anD morE persistent enhANcemEnt on MRI. Low grade leptomEningEaL InflAMmAtion Was seen IN uP TO 50% of PaTiEntS aT 3 YeArs buT drOpped fuRther at 5yeaRs. ALtHough no new boNE lEsions occuRreD with anakinrA trEatmenT, pReeXIstinG boNy lesIons coNTinued To expand oN", "whitespace_perturbation": " anakinra had already sign ificant he aring  lo ssat  bas elin e and more per s iste nt enhancement on MRI.  Lowgr a de l e pt omeni ngeal i n fl a m mat io nwas  s e en  in u p t o 50% o f patients  at  3  years but d r op ped furthe r a t 5years. Al tho ugh no  n ewb one l esi ons o ccurre d  withanakinratr e atment ,  preexi s t in g bo ny lesions contin u ed to expand on", "underscore_trick": " anakinra_had already_significant hearing loss at_baseline and_more_persistent enhancement_on_MRI. Low grade_leptomeningeal inflammation was_seen in up to_50% of patients_at_3 years but dropped further at 5years. Although no new bone lesions occurred with_anakinra_treatment, preexisting_bony_lesions_continued to expand on"}
{"text": " increased the levels of cDNA that retained the PPT at the 3? end. In order to determine whether this added sequence resulted from a defect in the cleavages that generate the PPT or the cleavage that removes the PPT after synthesis of plus strand DNA, the 5? end of the plus strand DNA was analyzed", "synonym_substitution": "increased the levels of cDNA that retained the PPT at the 3? goal. In decree to determine whether this added sequence leave from a defect in the cleavages that beget the PPT or the cleavage that take out the PPT after synthesis of plus strand DNA, the 5? goal of the plus strand DNA was analyzed", "butter_fingers": " infreased the levels of cDKA that retained the PPV at ths 3? end. Iv order to determine whether tyis aeded sequence resulted from a dvfect in rhe rleavages that gxherate bke PPF or chx cleavage that removes tve PPT after sfnghzsis of plus strand DNA, the 5? end of ehe plux dtrand DNA was anakrzed", "random_deletion": "increased the levels of cDNA that retained at 3? end. order to determine from defect in the that generate the or the cleavage that removes the after synthesis of plus strand DNA, the 5? end of the plus strand was analyzed", "change_char_case": " increased the levels of cDNA tHat retaineD the PpT aT thE 3? eNd. In OrdeR to determine whETher This added sequence resulTed frOm A DefeCT iN the cLeavageS ThAT GenErAtE thE Ppt oR the cLeaVage thaT removes thE PPt aFter synthesiS Of Plus strand dNA, The 5? end of the pLus Strand dNa waS AnalyZed", "whitespace_perturbation": " increased the levels of c DNA that r etain edthe  P PT a t th e 3? end. In o r derto determine whether t his a dd e d se q ue nce r esulted fr o m  ade fe ctin th e cle ava ges tha t generate  th ePPT or the c l ea vage thatrem oves the PPT  af ter sy nt hes i s ofplu s str and DN A , the5? end of  t h e plus strandD N Awasanalyzed", "underscore_trick": " increased_the levels_of cDNA that retained_the PPT_at_the 3?_end._In order to_determine whether this_added sequence resulted from_a defect in_the_cleavages that generate the PPT or the cleavage that removes the PPT after synthesis_of_plus strand_DNA,_the_5? end of the plus_strand DNA was analyzed"}
{"text": ", the emphasis of the DCTD on unmet medical need in uncommon cancers will result in a more centralized center where physicians can access these validated assays that may be very useful in personalizing each cancer patient's therapy based on molecular markers. Many of these PD assays will provide important information about molecular targeted therapy trials sponsored by", "synonym_substitution": ", the emphasis of the DCTD on unmet medical need in uncommon cancer will leave in a more centralized center where physicians can access these validate assay that may be very useful in personalizing each cancer affected role's therapy based on molecular markers. Many of these PD assays will supply important information about molecular targeted therapy trial sponsored by", "butter_fingers": ", thf emphasis of the DCTD ok unmet medical uwed in uncomjon cancdrs will result in a more ceitraoized center where physiciavs can acbess thesw vaoudated assegs that may bs verv nseful in persokalizing eawh cancer patiang's therapy based on molecular markers. Many og hhese PD assayf wikj prknibe important information about joleculer targeted thetapy trials sponsored by", "random_deletion": ", the emphasis of the DCTD on need uncommon cancers result in a can these validated assays may be very in personalizing each cancer patient's therapy on molecular markers. Many of these PD assays will provide important information about targeted therapy trials sponsored by", "change_char_case": ", the emphasis of the DCTD on unmEt medical nEed in UncOmmOn CancErs wIll result in a moRE cenTralized center where phySiciaNs CAn acCEsS thesE validaTEd ASSayS tHaT maY bE VeRy useFul In persoNalizing eaCh cAnCer patient's tHErApy based on MolEcular markerS. MaNy of thEsE PD ASsays WilL provIde impORtant iNformatioN aBOut molECular taRGEtEd thErapy trials sponsoREd BY", "whitespace_perturbation": ", the emphasis of the DCTD  on unmetmedic alnee din u ncom mon cancers wi l l re sult in a more central izedce n terw he re ph ysician s  c a n  ac ce ss  th es e  v alida ted  assays  that maybeve ry useful in pe rsonalizin g e ach cancer p ati ent'sth era p y bas edon mo lecula r  marke rs. Manyof theseP D assay s wi ll p rovide importanti nf o rmation aboutmolecu la r  t a r get edtherapy tr ia ls sp o nsoredb y", "underscore_trick": ", the_emphasis of_the DCTD on unmet_medical need_in_uncommon cancers_will_result in a_more centralized center_where physicians can access_these validated assays_that_may be very useful in personalizing each cancer patient's therapy based on molecular markers._Many_of these_PD_assays_will provide important information about_molecular targeted therapy trials sponsored_by"}
{"text": " with Tf1 that induced transposition. The version of Tf1 we expressed contained a neo gene to cause target plasmids with insertions to gain resistance to kanamycin. When Tf1-neo was expressed, the plasmid with ade6 served as an efficient target for integration. We isolated 50 separate insertions in the", "synonym_substitution": "with Tf1 that induced transposition. The version of Tf1 we expressed control a neo gene to induce target plasmids with interpolation to acquire resistance to kanamycin. When Tf1 - neo was expressed, the plasmid with ade6 suffice as an effective target for integration. We isolated 50 separate insertions in the", "butter_fingers": " wihh Tf1 that induced transkosition. The versnin of Vf1 we espressed contained a neo gene to caude targtn plasmids with insergions to hain resustaice to kanamycin. When Tf1-kzo waa expxewsed, the plasmld with ade6 served as an afwieient target for integration. We isolwted 50 srpwrate insertiogs im the", "random_deletion": "with Tf1 that induced transposition. The version we contained a gene to cause gain to kanamycin. When was expressed, the with ade6 served as an efficient for integration. We isolated 50 separate insertions in the", "change_char_case": " with Tf1 that induced transposItion. The veRsion Of TF1 we ExPresSed cOntained a neo geNE to cAuse target plasmids with InserTiONs to GAiN resiStance tO KaNAMycIn. whEn TF1-nEO wAs expResSed, the pLasmid with Ade6 SeRved as an effiCIeNt target foR inTegration. We iSolAted 50 sePaRatE InserTioNs in tHe", "whitespace_perturbation": " with Tf1 that induced tra nsposition . The  ve rsi on  ofTf1we expressed c o ntai ned a neo gene to caus e tar ge t  pla s mi ds wi th inse r ti o n s t oga inre s is tance  to  kanamy cin. WhenTf1 -n eo was expre s se d, the pla smi d with ade6ser ved as  a n e f ficie nttarge t fori ntegra tion. Weis o lated5 0 separ a t einse rtions in the", "underscore_trick": " with_Tf1 that_induced transposition. The version_of Tf1_we_expressed contained_a_neo gene to_cause target plasmids_with insertions to gain_resistance to kanamycin._When_Tf1-neo was expressed, the plasmid with ade6 served as an efficient target for integration._We_isolated 50_separate_insertions_in the"}
{"text": " correlation between increased membrane-associated ARTS-1 protein, increased IL-6R and IL-1RII shedding, and decreased membrane-associated IL-6R and IL-1RII in cell lines overexpressing ARTS-1. Thus, ARTS-1 promotes the shedding of three distinct cytokine receptor", "synonym_substitution": "correlation between increased membrane - associated ARTS-1 protein, increased IL-6R and IL-1RII spill, and decrease membrane - associated IL-6R and IL-1RII in cell lines overexpressing ARTS-1. therefore, ARTS-1 promotes the shedding of three distinct cytokine sense organ", "butter_fingers": " cogrelation between increared membrane-associated ARTS-1 lrotein, kncreased IL-6R and IL-1RII shedving, and eecreased membrane-assoziated IL-6G and IL-1RUI ii cell lines ovecsxpresslug ARFD-1. Thbs, ARTS-1 promotes the sheddhng of three dhsgiuct cytokine receptor", "random_deletion": "correlation between increased membrane-associated ARTS-1 protein, increased IL-1RII and decreased IL-6R and IL-1RII Thus, promotes the shedding three distinct cytokine", "change_char_case": " correlation between increasEd membrane-AssocIatEd ArTs-1 proTein, Increased IL-6R anD iL-1RIi shedding, and decreased mEmbraNe-ASsocIAtEd IL-6R And IL-1RIi In CELl lInEs OveReXPrEssinG ARtS-1. Thus, ArTS-1 promoteS thE sHedding of thrEE dIstinct cytOkiNe receptor", "whitespace_perturbation": " correlation between incre ased membr ane-a sso cia te d AR TS-1  protein, incr e ased  IL-6R and IL-1RII she dding ,a nd d e cr eased  membra n e- a s soc ia te d I L- 6 Rand I L-1 RII incell lines  ov er expressing A R TS -1. Thus,ART S-1 promotes  th e shed di ngo f thr eedisti nct cy t okinereceptor", "underscore_trick": " correlation_between increased_membrane-associated ARTS-1 protein, increased_IL-6R and_IL-1RII_shedding, and_decreased_membrane-associated IL-6R and_IL-1RII in cell_lines overexpressing ARTS-1. Thus,_ARTS-1 promotes the_shedding_of three distinct cytokine receptor"}
{"text": " BST-2 ectodomain. Importantly, our data indicate that BST-2 dimerization is not sufficient for inhibition of virus release since not all dimerization-competent BST-2 variants were functional in our virus release assay. Our results expose new structural constraints governing the functional dimerization of BST", "synonym_substitution": "BST-2 ectodomain. Importantly, our data indicate that BST-2 dimerization is not sufficient for inhibition of virus release since not all dimerization - competent BST-2 random variable were running in our virus release assay. Our results disclose raw structural constraints govern the running dimerization of BST", "butter_fingers": " BSH-2 ectodomain. Importantly, our data indiccre thav BST-2 djmerizatkon is not sufficient for iniibirion if virus release since not all fimerizarion-rompetent BST-2 vacjants wcxe fuhgtioncl in our virus telease assaf. Our results axoode new structural constraints goverging thr vunctional dimgrizauiog of BST", "random_deletion": "BST-2 ectodomain. Importantly, our data indicate that is sufficient for of virus release variants functional in our release assay. Our expose new structural constraints governing the dimerization of BST", "change_char_case": " BST-2 ectodomain. Importantly, oUr data indiCate tHat bST-2 DiMeriZatiOn is not sufficiENt foR inhibition of virus releAse siNcE Not aLL dImeriZation-cOMpETEnt bSt-2 vAriAnTS wEre fuNctIonal in Our virus reLeaSe Assay. Our resuLTs Expose new sTruCtural constrAinTs goveRnIng THe funCtiOnal dImerizATion of bST", "whitespace_perturbation": " BST-2 ectodomain. Importa ntly, ourdataind ica te  tha t BS T-2 dimerizati o n is  not sufficient for in hibit io n  ofv ir us re lease s i nc e not  a ll  di me r iz ation -co mpetent  BST-2 var ian ts  were functi o na l in our v iru s release as say . Ourre sul t s exp ose  newstruct u ral co nstraints  g o vernin g  the fu n c ti onal  dimerization ofB ST ", "underscore_trick": " BST-2_ectodomain. Importantly,_our data indicate that_BST-2 dimerization_is_not sufficient_for_inhibition of virus_release since not_all dimerization-competent BST-2 variants_were functional in_our_virus release assay. Our results expose new structural constraints governing the functional dimerization of_BST"}
{"text": " of tyrosine kinase and phosphatase activity plays a key role in how cells regulate their cell surface area. Cell proliferation, as observed in tumors, requires a constant increase in cell surface area to support multiple rounds of cell division. Our finding suggests that the increase in Src kinase activity observed in many tumors might disrupt cell surface homeostasis by", "synonym_substitution": "of tyrosine kinase and phosphatase activity plays a key role in how cell determine their cell surface area. cellular telephone proliferation, as observed in tumors, requires a changeless increase in cell open area to support multiple round of cell division. Our determination suggests that the increase in Src kinase activity observed in many tumors might disrupt cell open homeostasis by", "butter_fingers": " of tyrosine kinase and phorphatase activijy plays a key role in how cells regulate their cepl surfqce area. Cell proliferxtion, as lbserved in uumors, requires a constanb incdcase nn cell surface srea to su[port multiple ruuuds of cell division. Our finding sugdests tnah the increase in Xwc kjnase activity observed in many tujors mijht disrupt celk surface homeostasis by", "random_deletion": "of tyrosine kinase and phosphatase activity plays role how cells their cell surface in requires a constant in cell surface to support multiple rounds of cell Our finding suggests that the increase in Src kinase activity observed in many might disrupt cell surface homeostasis by", "change_char_case": " of tyrosine kinase and phosphAtase activIty plAys A keY rOle iN how Cells regulate tHEir cEll surface area. Cell prolIferaTiON, as oBSeRved iN tumors, REqUIRes A cOnStaNt INcRease In cEll surfAce area to sUppOrT multiple rouNDs Of cell diviSioN. Our finding sUggEsts thAt The INcreaSe iN Src kInase aCTivity Observed iN mANy tumoRS might dISRuPt ceLl surface homeostaSIs BY", "whitespace_perturbation": " of tyrosine kinase and ph osphataseactiv ity  pl ay s akeyrole in how ce l ls r egulate their cell sur facear e a. C e ll  prol iferati o n, a s o bs er ved  i n  t umors , r equires  a constan t i nc rease in cel l  s urface are a t o support mu lti ple ro un dso f cel l d ivisi on. Ou r  findi ng sugges ts that t h e incre a s ein S rc kinase activit y  o b served in many  tumor sm ig h t  di sru pt cell su rf ace h o meostas i sb y ", "underscore_trick": " of_tyrosine kinase_and phosphatase activity plays_a key_role_in how_cells_regulate their cell_surface area. Cell_proliferation, as observed in_tumors, requires a_constant_increase in cell surface area to support multiple rounds of cell division. Our finding_suggests_that the_increase_in_Src kinase activity observed in_many tumors might disrupt cell_surface homeostasis_by"}
{"text": " EpCAM function. An initial series of investigations regarding EpCAM function in Langerhans cells has been completed and the findings were published in the Proceedings of the National Academy of Science in 2012. We determined that Langerhans cells that fail to express EpCAM exhibit decreased motility in epidermis and exit epidermis more slowly than", "synonym_substitution": "EpCAM function. An initial series of investigations regarding EpCAM affair in Langerhans cell has been completed and the findings were published in the Proceedings of the National Academy of Science in 2012. We determine that Langerhans cells that fail to express EpCAM display decreased motility in epidermis and exit epidermis more lento than", "butter_fingers": " EpFAM function. An initial reries of invesjitationv regadding EpZAM function in Langerhans cxlls has veen completed and the findings were puvlisied in the Procexsings on the Katiouao Academy of Sgience in 2012. Fe determined dhxt Langerhans cells that fail to exprqss EpCSM exhibit decrewsed iotimptn in epidermis and exit epidermia more vlowly than", "random_deletion": "EpCAM function. An initial series of investigations function Langerhans cells been completed and the of the National of Science in We determined that Langerhans cells that to express EpCAM exhibit decreased motility in epidermis and exit epidermis more slowly", "change_char_case": " EpCAM function. An initial serIes of invesTigatIonS reGaRdinG EpCaM function in LaNGerhAns cells has been completEd and ThE FindINgS were PublishED iN THe PRoCeEdiNgS Of The NaTioNal AcadEmy of ScienCe iN 2012. WE determined tHAt langerhans CelLs that fail to ExpRess EpcAm exHIbit dEcrEased MotiliTY in epiDermis and ExIT epideRMis more SLOwLy thAn", "whitespace_perturbation": " EpCAM function. An initia l series o f inv est iga ti onsrega rding EpCAM fu n ctio n in Langerhans cellshas b ee n  com p le ted a nd thef in d i ngs  w er e p ub l is hed i n t he Proc eedings of  th eNational Aca d em y of Scien cein 2012. Wedet ermine dtha t  Lang erh ans c ells t h at fai l to expr es s  EpCAM exhibit d ec reas ed motility in ep i de r mis and exit e piderm is mo r e  sl owl y than", "underscore_trick": " EpCAM_function. An_initial series of investigations_regarding EpCAM_function_in Langerhans_cells_has been completed_and the findings_were published in the_Proceedings of the_National_Academy of Science in 2012. We determined that Langerhans cells that fail to express_EpCAM_exhibit decreased_motility_in_epidermis and exit epidermis more_slowly than"}
{"text": " has been submitted and is currently under review. We are currently working on 5 projects in the lab. Three of them are methodological, and the last two utilize our microscopes unique capabilities to answer biological questions: 1. We are in the final steps of data collection for a study that describes the generation and characterization of a set", "synonym_substitution": "has been submitted and is currently under review. We are currently work on 5 undertaking in the lab. Three of them are methodological, and the last two utilize our microscopes singular capabilities to answer biological doubt: 1. We are in the concluding steps of data collection for a study that describes the genesis and characterization of a set", "butter_fingers": " had been submitted and is gurrently under teciew. Wx are chrrently working on 5 projects in the lqb. Theee of them are methodulogical, wnd the oast rwo utilizx our migxoscolcs unnqne capabilities to answer biological quasgilns: 1. We are in the final steps of dwta colkeftion for a stody tnwt dsscribes the generation and characferizatpon of a set", "random_deletion": "has been submitted and is currently under are working on projects in the methodological, the last two our microscopes unique to answer biological questions: 1. We in the final steps of data collection for a study that describes the and characterization of a set", "change_char_case": " has been submitted and is currEntly under RevieW. We Are CuRrenTly wOrking on 5 projecTS in tHe lab. Three of them are metHodolOgICal, aND tHe lasT two utiLIzE OUr mIcRoScoPeS UnIque cApaBilitieS to answer bIolOgIcal questionS: 1. we Are in the fiNal Steps of data cOllEction FoR a sTUdy thAt dEscriBes the GEneratIon and chaRaCTerizaTIon of a sET", "whitespace_perturbation": " has been submitted and is  currently  unde r r evi ew . We  are  currently wor k ingon 5 projects in the l ab. T hr e e of th em ar e metho d ol o g ica l,  a ndth e  l ast t woutilize  our micro sco pe s unique cap a bi lities toans wer biologic alquesti on s:1 . Weare  in t he fin a l step s of data  c o llecti o n for a s tu dy t hat describes the ge n eration and ch aracte ri z at i o n o f a  set", "underscore_trick": " has_been submitted_and is currently under_review. We_are_currently working_on_5 projects in_the lab. Three_of them are methodological,_and the last_two_utilize our microscopes unique capabilities to answer biological questions: 1. We are in the_final_steps of_data_collection_for a study that describes_the generation and characterization of_a set"}
{"text": ", polyacrylic acid, and different biopolymers such as DNA, hyaluronic acid and chondroitin sulfate (important components of extracellular matrix) to determine the size of the structural elements that contribute to the osmotic concentration fluctuations. We have combined SANS and SAXS to estimate the osmotic modulus of", "synonym_substitution": ", polyacrylic acid, and different biopolymers such as DNA, hyaluronic acid and chondroitin sulfate (important components of extracellular matrix) to determine the size of the geomorphologic chemical element that contribute to the osmotic concentration fluctuations. We own combined SANS and SAXS to estimate the osmotic modulus of", "butter_fingers": ", popyacrylic acid, and diffevent biopolymers such av DNA, gyaluronkc acid and chondroitin sulfete (umporucnt components of exgracellulwr matriz) to eetermine vge size of ths strbcvural elements jhat contribgte to the osmmtkc concentration fluctuations. We have combinrd SANS and SAXS to tstymats the osmotic modulus of", "random_deletion": ", polyacrylic acid, and different biopolymers such hyaluronic and chondroitin (important components of size the structural elements contribute to the concentration fluctuations. We have combined SANS SAXS to estimate the osmotic modulus of", "change_char_case": ", polyacrylic acid, and differeNt biopolymErs suCh aS DNa, hYaluRoniC acid and chondrOItin Sulfate (important componEnts oF eXTracELlUlar mAtrix) to DEtERMinE tHe SizE oF ThE struCtuRal elemEnts that coNtrIbUte to the osmoTIc ConcentratIon Fluctuations. we hAve comBiNed saNS anD SAxS to eStimatE The osmOtic modulUs OF", "whitespace_perturbation": ", polyacrylic acid, and di fferent bi opoly mer s s uc h as  DNA , hyaluronic a c id a nd chondroitin sulfate  (imp or t antc om ponen ts of e x tr a c ell ul ar  ma tr i x)  to d ete rmine t he size of  th estructural e l em ents thatcon tribute to t heosmoti ccon c entra tio n flu ctuati o ns. We  have com bi n ed SAN S  and SA X S  t o es timate the osmoti c  m o dulus of", "underscore_trick": ", polyacrylic_acid, and_different biopolymers such as_DNA, hyaluronic_acid_and chondroitin_sulfate_(important components of_extracellular matrix) to_determine the size of_the structural elements_that_contribute to the osmotic concentration fluctuations. We have combined SANS and SAXS to estimate_the_osmotic modulus_of"}
{"text": " affinity of the T cell for foreign pMHC. In addition, in comparison to other cell surface proteins, CD5 (whose level of expression marks self-pMHC affinity of a T cell) is skewed to the right compared to a log normal distribution. These results indicate that thymic positive selection operates to maximize", "synonym_substitution": "affinity of the T cell for foreign pMHC. In addition, in comparison to early cellular telephone airfoil proteins, CD5 (whose degree of formulation marks self - pMHC affinity of a T cell) is skew to the right compared to a log normal distribution. These consequence indicate that thymic positive excerpt operates to maximize", "butter_fingers": " afvinity of the T cell for foreign pMHC. Iu additmon, in domparisun to other cell surface proveinw, CD5 (qhose level of expresskon marks self-pMHX afhinity of a T cell) is skcced tk the cight compared jo a log norkal distributimn. Tkese results indicate that thymic pofitive xepection operatgs to iaxijpzt", "random_deletion": "affinity of the T cell for foreign addition, comparison to cell surface proteins, marks affinity of a cell) is skewed the right compared to a log distribution. These results indicate that thymic positive selection operates to maximize", "change_char_case": " affinity of the T cell for foreIgn pMHC. In aDditiOn, iN coMpArisOn to Other cell surfaCE proTeins, CD5 (whose level of expRessiOn MArks SElF-pMHC AffinitY Of A t CelL) iS sKewEd TO tHe rigHt cOmpared To a log normAl dIsTribution. TheSE rEsults indiCatE that thymic pOsiTive seLeCtiON operAteS to maXimize", "whitespace_perturbation": " affinity of the T cell fo r foreignpMHC.  In  ad di tion , in  comparison to othe r cell surface protein s, CD 5( whos e  l evelof expr e ss i o n m ar ks  se lf - pM HC af fin ity ofa T cell)issk ewed to ther ig ht compare d t o a log norm aldistri bu tio n . The seresul ts ind i cate t hat thymi cp ositiv e  select i o noper ates to maximize", "underscore_trick": " affinity_of the_T cell for foreign_pMHC. In_addition,_in comparison_to_other cell surface_proteins, CD5 (whose_level of expression marks_self-pMHC affinity of_a_T cell) is skewed to the right compared to a log normal distribution. These_results_indicate that_thymic_positive_selection operates to maximize"}
{"text": "icity five months after transplantation. 1.2 First-in-human clinical trial testing safety/efficacy of FV for gene therapy of patients with LAD-1. Based on pre-clinical evidence of safety and efficacy discussed above, we have designed a first-in-human phase I/II gene therapy clinical trial", "synonym_substitution": "icity five months after transplantation. 1.2 First - in - human clinical trial examination condom / efficacy of FV for gene therapy of patients with LAD-1. Based on pre - clinical evidence of condom and efficacy hash out above, we have designed a first - in - homo phase I / II gene therapy clinical trial", "butter_fingers": "icihy five months after traksplantation. 1.2 Fitsr-in-humen clinjcal trixl testing safety/efficacy of FC for gene therapy of patievts with PAD-1. Basee on pre-clinical evidengz of awfetv end efficacy dixcussed abmve, we have devienzd a first-in-human phase I/II gene thewapy clonlcal trial", "random_deletion": "icity five months after transplantation. 1.2 First-in-human testing of FV gene therapy of pre-clinical of safety and discussed above, we designed a first-in-human phase I/II gene clinical trial", "change_char_case": "icity five months after transPlantation. 1.2 first-In-hUmaN cLiniCal tRial testing safETy/efFicacy of FV for gene theraPy of pAtIEnts WItH LAD-1. BAsed on pRE-cLINicAl EvIdeNcE Of SafetY anD efficaCy discusseD abOvE, we have desigNEd A first-in-huMan Phase I/II gene TheRapy clInIcaL Trial", "whitespace_perturbation": "icity five months after tr ansplantat ion.1.2  Fi rs t-in -hum an clinical tr i al t esting safety/efficacy  of F Vf or g e ne  ther apy ofp at i e nts  w it h L AD - 1.  Base d o n pre-c linical ev ide nc e of safetya nd  efficacydis cussed above , w e have  d esi g ned a  fi rst-i n-huma n  phase  I/II gen et herapy clinica l tr ial", "underscore_trick": "icity five_months after_transplantation. 1.2 First-in-human clinical_trial testing_safety/efficacy_of FV_for_gene therapy of_patients with LAD-1._Based on pre-clinical evidence_of safety and_efficacy_discussed above, we have designed a first-in-human phase I/II gene therapy clinical trial"}
{"text": " the affinity of the cells selected into the mature pool, up the to limit set by negative selection, and provide a strong evolutionary rationale for the process of thymic positive selection - maximizing the ability of the mature T cell pool to recognize and respond to foreign antigens. In vivo evidence for the relevance of these findings came from studies", "synonym_substitution": "the affinity of the cells selected into the mature pool, up the to restrict rig by negative selection, and provide a potent evolutionary rationale for the process of thymic positive excerpt - maximize the ability of the mature thymine cell pool to greet and respond to foreign antigen. In vivo evidence for the relevance of these findings came from studies", "butter_fingers": " thf affinity of the cells relected into tkw matuce pool, up the go limit set by negative selxctiin, ane provide a strong evouutionary rationaoe fie the procxas of tmvmic llsitnvx selection - mawimizing tha ability of tve mcture T cell pool to recognize and rqspond yo foreign antiggns. Im vivk evidence for the relevance of thsse finvings came from studies", "random_deletion": "the affinity of the cells selected into pool, the to set by negative evolutionary for the process thymic positive selection maximizing the ability of the mature cell pool to recognize and respond to foreign antigens. In vivo evidence for relevance of these findings came from studies", "change_char_case": " the affinity of the cells seleCted into thE matuRe pOol, Up The tO limIt set by negativE SeleCtion, and provide a strong EvoluTiONary RAtIonalE for the PRoCESs oF tHyMic PoSItIve seLecTion - maxImizing the AbiLiTy of the maturE t cEll pool to rEcoGnize and respOnd To foreIgN anTIgens. in vIvo evIdence FOr the rElevance oF tHEse finDIngs camE FRoM stuDies", "whitespace_perturbation": " the affinity of the cells  selectedintothe  ma tu re p ool,  up the to lim i t se t by negative selectio n, an dp rovi d ea str ong evo l ut i o nar yra tio na l efor t heprocess  of thymic  po si tive selecti o n- maximizi ngthe abilityofthe ma tu reT  cell  po ol to  recog n ize an d respond  t o  forei g n antig e n s.  Invivo evidence for th e  relevance ofthesefi n di n g s c ame  from stud ie s", "underscore_trick": " the_affinity of_the cells selected into_the mature_pool,_up the_to_limit set by_negative selection, and_provide a strong evolutionary_rationale for the_process_of thymic positive selection - maximizing the ability of the mature T cell pool_to_recognize and_respond_to_foreign antigens. In vivo evidence_for the relevance of these_findings came_from studies"}
{"text": " that have genetic bases. We currently have six ongoing studies that fall within these aims. With respect to highly penetrant genetic disorders, we are investigating the dissemination of genetic risk information and adaptation to risk in women from families with known BRCA1/2 mutations (NCI Protocol #01-C-0009; PI: Jennifer", "synonym_substitution": "that have genetic bases. We currently get six ongoing cogitation that fall within these aim. With deference to highly penetrant genetic disorders, we are investigate the dispersion of genetic risk information and adaptation to risk in women from family with known BRCA1/2 mutations (NCI Protocol # 01 - C-0009; PI: Jennifer", "butter_fingers": " thwt have genetic bases. We currently have six onjoing sfudies tfat fall within these aims. Wmth eespext to highly penetrant genetic fisorderw, we qre investmfating bke diademiuavion of genetic risk infosmation and addpgacion to risk in women from families rith knpwj BRCA1/2 mutatiogs (NBI Profocol #01-C-0009; PI: Jennifer", "random_deletion": "that have genetic bases. We currently have studies fall within aims. With respect we investigating the dissemination genetic risk information adaptation to risk in women from with known BRCA1/2 mutations (NCI Protocol #01-C-0009; PI: Jennifer", "change_char_case": " that have genetic bases. We curRently have Six onGoiNg sTuDies That Fall within thesE Aims. with respect to highly penEtranT gENetiC DiSordeRs, we are INvESTigAtInG thE dISsEminaTioN of geneTic risk infOrmAtIon and adaptaTIoN to risk in wOmeN from familieS wiTh knowN BrCA1/2 MUtatiOns (nCI PrOtocol #01-c-0009; pI: JennIfer", "whitespace_perturbation": " that have genetic bases.We current ly ha vesix  o ngoi ng s tudies that fa l l wi thin these aims. Withrespe ct to h i gh ly pe netrant ge n e tic  d is ord er s ,we ar e i nvestig ating thedis se mination ofg en etic riskinf ormation and  ad aptati on  to riskinwomen  fromf amilie s with kn ow n  BRCA1 / 2 mutat i o ns  (NC I Protocol #01-C- 0 00 9 ; PI: Jennifer ", "underscore_trick": " that_have genetic_bases. We currently have_six ongoing_studies_that fall_within_these aims. With_respect to highly_penetrant genetic disorders, we_are investigating the_dissemination_of genetic risk information and adaptation to risk in women from families with known_BRCA1/2_mutations (NCI_Protocol_#01-C-0009;_PI: Jennifer"}
{"text": " key to the successful introduction of additional clinical PD assays into the early clinical trial setting. These steps are definable and have objective metrics that allow decisions at each stage of development and validation regarding feasibility and go/no-go decisions by management. They are amenable to formalized statements of work that could be used to outsource", "synonym_substitution": "key to the successful introduction of additional clinical PD assay into the early clinical test setting. These steps are definable and have objective metric function that allow decisions at each phase of development and validation see feasibility and go / no - fit decisions by management. They are amenable to validate statement of work that could be used to outsource", "butter_fingers": " kej to the successful intruduction of addnrional clinidal PD arsays into the early clinicap rrial setting. These steps afe definahle and yave ibjective metrics bkat ampow berisions at each stage of gevelopment ang xapidation regarding feasibility and do/no-go cefisions by manwgemtnt. Theg are amenable to formalized statejents oh work that coukd be used to outsource", "random_deletion": "key to the successful introduction of additional assays the early trial setting. These objective that allow decisions each stage of and validation regarding feasibility and go/no-go by management. They are amenable to formalized statements of work that could be to outsource", "change_char_case": " key to the successful introduCtion of addItionAl cLinIcAl PD AssaYs into the early CLiniCal trial setting. These stEps arE dEFinaBLe And haVe objecTIvE MEtrIcS tHat AlLOw DecisIonS at each Stage of devEloPmEnt and validaTIoN regarding FeaSibility and gO/no-Go deciSiOns BY manaGemEnt. ThEy are aMEnable To formaliZeD StatemENts of woRK ThAt coUld be used to outsouRCe", "whitespace_perturbation": " key to the successful int roductionof ad dit ion al  cli nica l PD assays in t o th e early clinical trial  sett in g . Th e se  step s are d e fi n a ble  a nd  ha ve ob jecti vemetrics  that allo w d ec isions at ea c hstage of d eve lopment andval idatio nreg a rding  fe asibi lity a n d go/n o-go deci si o ns bym anageme n t .They  are amenable tof or m alized stateme nts of  w o rk t hat  co uld be use dto ou t source", "underscore_trick": " key_to the_successful introduction of additional_clinical PD_assays_into the_early_clinical trial setting._These steps are_definable and have objective_metrics that allow_decisions_at each stage of development and validation regarding feasibility and go/no-go decisions by management._They_are amenable_to_formalized_statements of work that could_be used to outsource"}
{"text": "Pase activity in an in vitro assay, we identified one phospho site important for the ability of SAMHD1 to restrict HIV-1. Our results therefore indicate that SAMHD1 phosphorylation could be a regulator of SAMHD1 restriction activity. This project is ongoing and further analysis of SAMHD1 post-translational modifications", "synonym_substitution": "Pase activity in an in vitro assay, we identified one phospho site important for the ability of SAMHD1 to qualify HIV-1. Our result therefore indicate that SAMHD1 phosphorylation could be a governor of SAMHD1 restriction activeness. This project is ongoing and further analysis of SAMHD1 post - translational alteration", "butter_fingers": "Pasf activity in an in vitru assay, we idenjidied oie phoslho site important for the ability oh SANHD1 ti restrict HIV-1. Our resjlts thervfore inducatt that SAMHD1 phos'gorylatljn ckmld bz e regulator of XAMHD1 restsiction actividy. Tkis project is ongoing and further agalysis ov SAMHD1 post-trwnslseionzl modifications", "random_deletion": "Pase activity in an in vitro assay, one site important the ability of results indicate that SAMHD1 could be a of SAMHD1 restriction activity. This project ongoing and further analysis of SAMHD1 post-translational modifications", "change_char_case": "Pase activity in an in vitro asSay, we identIfied One PhoSpHo siTe imPortant for the aBIlitY of SAMHD1 to restrict HIV-1. OUr resUlTS theREfOre inDicate tHAt samHD1 PhOsPhoRyLAtIon coUld Be a reguLator of SAMhD1 rEsTriction actiVItY. This projeCt iS ongoing and fUrtHer anaLySis OF SAMHd1 poSt-traNslatiONal modIficationS", "whitespace_perturbation": "Pase activity in an in vit ro assay,we id ent ifi ed  one  pho spho site impo r tant  for the ability of SA MHD1to rest r ic t HIV -1. Our re s u lts  t he ref or e  i ndica tethat SA MHD1 phosp hor yl ation couldb ea regulato r o f SAMHD1 res tri ctionac tiv i ty. T his  proj ect is ongoin g and fur th e r anal y sis ofS A MH D1 p ost-translational mo d ifications", "underscore_trick": "Pase activity_in an_in vitro assay, we_identified one_phospho_site important_for_the ability of_SAMHD1 to restrict_HIV-1. Our results therefore_indicate that SAMHD1_phosphorylation_could be a regulator of SAMHD1 restriction activity. This project is ongoing and further_analysis_of SAMHD1_post-translational_modifications"}
{"text": " being used in a family-based family health history initiative funded by the Australian Research Council and co-sponsored by the Cancer Council of South Australia; data collection on this project was completed in 2014. A paper describing this effort is currently in review and a baseline paper describing the family network systems is in preparation. Our research has", "synonym_substitution": "being used in a family - based family health history enterprise fund by the Australian Research Council and co - sponsored by the Cancer Council of South Australia; data collection on this undertaking was completed in 2014. A paper describing this attempt is currently in review and a service line newspaper describing the syndicate network systems is in training. Our research take", "butter_fingers": " belng used in a family-basea family health historb initiztive fuvded by the Australian Reseacch Xouncul and co-sponsored by ghe Canceg Council of Wiuth Austremia; data collsgtion in this projecj was compleded in 2014. A papes aedcribing this effort is currently ig reviee wnd a baseline paptr qescdpblng the family network systems ia in prtparation. Our resesrch has", "random_deletion": "being used in a family-based family health funded the Australian Council and co-sponsored South data collection on project was completed 2014. A paper describing this effort currently in review and a baseline paper describing the family network systems is preparation. Our research has", "change_char_case": " being used in a family-based faMily health HistoRy iNitIaTive FundEd by the AustralIAn ReSearch Council and co-sponSored By THe CaNCeR CounCil of SoUTh aUStrAlIa; DatA cOLlEctioN on This proJect was comPleTeD in 2014. A paper desCRiBing this efForT is currently In rEview aNd A baSEline PapEr desCribinG The famIly networK sYStems iS In prepaRATiOn. OuR research has", "whitespace_perturbation": " being used in a family-ba sed family  heal thhis to ry i niti ative funded b y  the  Australian Research C ounci la nd c o -s ponso red byt he C anc er  C oun ci l  o f Sou thAustral ia; data c oll ec tion on this pr oject wascom pleted in 20 14.  A pap er  de s cribi ngthiseffort is cur rently in  r e view a n d a bas e l in e pa per describing th e  f a mily network s ystems  i s  i n pre par ation. Our  r esear c h has", "underscore_trick": " being_used in_a family-based family health_history initiative_funded_by the_Australian_Research Council and_co-sponsored by the_Cancer Council of South_Australia; data collection_on_this project was completed in 2014. A paper describing this effort is currently in_review_and a_baseline_paper_describing the family network systems_is in preparation. Our research_has"}
{"text": " Loud). This research uses the Colored Eco-genetic Relationship Map (CEGRM) to assess the communication and social support networks of study participants. Currently, 200 participants have been recruited into the study. CEGRM assessments and psychosocial measurements were obtained at baseline and at three annual follow-ups. We have", "synonym_substitution": "Loud). This research uses the Colored Eco - genetic Relationship Map (CEGRM) to assess the communication and social documentation net of study participants. Currently, 200 player have been recruited into the study. CEGRM judgment and psychosocial measurement were obtained at baseline and at three annual follow - ups. We have", "butter_fingers": " Lokd). This research uses tht Colored Eco-genejix Relavionshil Map (CEERM) to assess the communicatmon qnd sicial support networks of study participantw. Currently, 200 particl'ants mave yexn recruited injo the study. CEGRM assessmangs and psychosocial measurements were obtainrd at baseline agd au trree annual follow-ups. We have", "random_deletion": "Loud). This research uses the Colored Eco-genetic (CEGRM) assess the and social support 200 have been recruited the study. CEGRM and psychosocial measurements were obtained at and at three annual follow-ups. We have", "change_char_case": " Loud). This research uses the CoLored Eco-geNetic relAtiOnShip map (CeGRM) to assess thE CommUnication and social suppOrt neTwORks oF StUdy paRticipaNTs. cURreNtLy, 200 ParTiCIpAnts hAve Been recRuited into The StUdy. CEGRM asseSSmEnts and psyChoSocial measurEmeNts werE oBtaINed at BasEline And at tHRee annUal follow-UpS. we have", "whitespace_perturbation": " Loud). This research uses  the Color ed Ec o-g ene ti c Re lati onship Map (CE G RM)to assess the communic ation  a n d so c ia l sup port ne t wo r k s o fst udy  p a rt icipa nts . Curre ntly, 200par ti cipants have be en recruit edinto the stu dy.  CEGRM  a sse s sment s a nd ps ychoso c ial me asurement sw ere ob t ained a t ba seli ne and at three a n nu a l follow-ups.We hav e", "underscore_trick": " Loud)._This research_uses the Colored Eco-genetic_Relationship Map_(CEGRM)_to assess_the_communication and social_support networks of_study participants. Currently, 200_participants have been_recruited_into the study. CEGRM assessments and psychosocial measurements were obtained at baseline and at_three_annual follow-ups._We_have"}
{"text": "-TP and ETV-TP form good van der Waals interactions with Met204 and Asp205 in the active site of HBVWT RT as seen from the analysis of the Connolly surface interactions. Importantly, the 4'-cyano group that CMCP contains in its cyclopentyl group forms good van der Wa", "synonym_substitution": "-TP and ETV - TP form good van der Waals interactions with Met204 and Asp205 in the active site of HBVWT RT as see from the psychoanalysis of the Connolly surface interactions. Importantly, the 4'-cyano group that CMCP control in its cyclopentyl group form good van der Wa", "butter_fingers": "-TP wnd ETV-TP form good van aer Waals intercxtions with Jet204 and Xsp205 in the active site of HBTWT ET as seen from the analysir of the Bonnolly wurfece interactions. Importakcly, tgc 4'-cyauo group that CMGP contains in its cyclopangyp group forms good van der Wa", "random_deletion": "-TP and ETV-TP form good van der with and Asp205 the active site from analysis of the surface interactions. Importantly, 4'-cyano group that CMCP contains in cyclopentyl group forms good van der Wa", "change_char_case": "-TP and ETV-TP form good van der WAals interaCtionS wiTh MEt204 And ASp205 in The active site oF hBVWt RT as seen from the analysIs of tHe cOnnoLLy SurfaCe interACtIONs. IMpOrTanTlY, ThE 4'-cyanO grOup that cMCP contaiNs iN iTs cyclopentyL GrOup forms goOd vAn der Wa", "whitespace_perturbation": "-TP and ETV-TP form good v an der Waa ls in ter act io ns w ithMet204 and Asp 2 05 i n the active site of H BVWTRT as s e en  from  the an a ly s i s o fth e C on n ol ly su rfa ce inte ractions.Imp or tantly, the4 '- cyano grou p t hat CMCP con tai ns init s c y clope nty l gro up for m s good  van derWa ", "underscore_trick": "-TP and_ETV-TP form_good van der Waals_interactions with_Met204_and Asp205_in_the active site_of HBVWT RT_as seen from the_analysis of the_Connolly_surface interactions. Importantly, the 4'-cyano group that CMCP contains in its cyclopentyl group forms_good_van der_Wa"}
{"text": " The role of IL-1 in Behcets disease will be investigated with the newly approved protocol. Project 1: Rac1 induces PCK-dependent myosinIIA phosphorylation to regulate association with focal adhesions and cell migration. Pasapera AM1, Fischer RS1,Plotnikov SV1,Egelhoff T", "synonym_substitution": "The role of IL-1 in Behcets disease will be investigated with the newly approved protocol. Project 1: Rac1 induce PCK - pendent myosinIIA phosphorylation to regulate association with focal adhesions and cellular telephone migration. Pasapera AM1, Fischer RS1,Plotnikov SV1,Egelhoff T", "butter_fingers": " Thf role of IL-1 in Behcets aisease will be investmgated sith the newly approved protocol. Prooect 1: Rac1 induces PCK-dependent oyosinIIA phosphoeylauion to regulate easociatljn wjbh foeao adhesions anc cell migsation. Pasaperd XM1, Fischer RS1,Plotnikov SV1,Egelhoff T", "random_deletion": "The role of IL-1 in Behcets disease investigated the newly protocol. Project 1: to association with focal and cell migration. AM1, Fischer RS1,Plotnikov SV1,Egelhoff T", "change_char_case": " The role of IL-1 in Behcets diseaSe will be inVestiGatEd wItH the NewlY approved protoCOl. PrOject 1: Rac1 induces PCK-depeNdent MyOSinIia pHosphOrylatiON tO REguLaTe AssOcIAtIon wiTh fOcal adhEsions and cEll MiGration. PasapERa aM1, Fischer Rs1,PlOtnikov SV1,EgeLhoFf T", "whitespace_perturbation": " The role of IL-1 in Behce ts disease  will  be  in ve stig ated  with the newl y  app roved protocol. Projec t 1:Ra c 1 in d uc es PC K-depen d en t myo si nI IAph o sp horyl ati on to r egulate as soc ia tion with fo c al  adhesions  an d cell migra tio n. Pas ap era AM1,Fis cherRS1,Pl o tnikov  SV1,Egel ho f f T", "underscore_trick": " The_role of_IL-1 in Behcets disease_will be_investigated_with the_newly_approved protocol. Project_1: Rac1 induces_PCK-dependent myosinIIA phosphorylation to_regulate association with_focal_adhesions and cell migration. Pasapera AM1, Fischer RS1,Plotnikov SV1,Egelhoff T"}
{"text": "ateral-prefrontal cortex (DLPFC) connectivity is heritable, independent of DLPFC activation, and is affected by a genetic variation in the ZNF804A gene. Siblings of patients with SZ showed increased DLPFC inefficiency vs. controls. Our connectivity analyses showed abnormal DLP", "synonym_substitution": "ateral - prefrontal cortex (DLPFC) connectivity is heritable, independent of DLPFC activation, and is involve by a familial variation in the ZNF804A gene. Siblings of patients with SZ prove increased DLPFC inefficiency vs. controls. Our connectivity analysis show abnormal DLP", "butter_fingers": "ategal-prefrontal cortex (DLPNC) connectivity nw herivable, ihdependevt of DLPFC activation, and id qffecuvd by a genetic variagion in tje ZNF804A tene. Wiblings oh patienbf wifm SZ viowed increased DLPFC inexficiency vs. cmngrlls. Our connectivity analyses showeq abnorkap DLP", "random_deletion": "ateral-prefrontal cortex (DLPFC) connectivity is heritable, independent activation, is affected a genetic variation of with SZ showed DLPFC inefficiency vs. Our connectivity analyses showed abnormal DLP", "change_char_case": "ateral-prefrontal cortex (DLPfC) connectiVity iS heRitAbLe, inDepeNdent of DLPFC acTIvatIon, and is affected by a genEtic vArIAtioN In The ZNf804A gene. SIBlINGs oF pAtIenTs WItH SZ shOweD increaSed DLPFC inEffIcIency vs. contrOLs. our connectIviTy analyses shOweD abnorMaL DLp", "whitespace_perturbation": "ateral-prefrontal cortex ( DLPFC) con necti vit y i sheri tabl e, independent of D LPFC activation, and i s aff ec t ed b y  a  gene tic var i at i o n i nth e Z NF 8 04 A gen e.Sibling s of patie nts  w ith SZ showe d  i ncreased D LPF C inefficien cyvs. co nt rol s . Our  co nnect ivitya nalyse s showedab n ormalD LP", "underscore_trick": "ateral-prefrontal cortex_(DLPFC) connectivity_is heritable, independent of_DLPFC activation,_and_is affected_by_a genetic variation_in the ZNF804A_gene. Siblings of patients_with SZ showed_increased_DLPFC inefficiency vs. controls. Our connectivity analyses showed abnormal DLP"}
{"text": ". This virus was attenuated in vitro but eventually reached titers comparable to those of HPIV3. Following IN infection of guinea pigs, this virus was highly attenuated and completely restricted to the respiratory tract but nonetheless was highly immunogenic. A single IN dose provided complete protection of guinea pigs against an otherwise lethal challenge of guinea pig-", "synonym_substitution": ". This virus was attenuated in vitro but eventually reached titers comparable to those of HPIV3. follow IN contagion of guinea pigs, this virus was highly rarefy and wholly restricted to the respiratory tract but nonetheless was highly immunogenic. A individual IN dose provided accomplished protection of guinea bull against an otherwise lethal challenge of guinea fowl pig-", "butter_fingers": ". Thls virus was attenuated ln vitro but eveurually reachsd titerr comparable to those of HPIT3. Foolowibg IN infection of guivea pigs, nhis viruw waw highly atvsnuated and cklpleceoy restricted jo the respisatory tract bgt nlnetheless was highly immunogenic. A single IJ dose provideq cok[lets protection of guinea pigs againsf an otierwise lethal vhallenge of guinea pig-", "random_deletion": ". This virus was attenuated in vitro reached comparable to of HPIV3. Following this was highly attenuated completely restricted to respiratory tract but nonetheless was highly A single IN dose provided complete protection of guinea pigs against an otherwise challenge of guinea pig-", "change_char_case": ". This virus was attenuated in vItro but eveNtualLy rEacHeD titErs cOmparable to thoSE of HpIV3. Following IN infectioN of guInEA pigS, ThIs virUs was hiGHlY ATteNuAtEd aNd COmPleteLy rEstrictEd to the resPirAtOry tract but nONeTheless was HigHly immunogenIc. A Single iN DosE ProviDed ComplEte proTEction Of guinea pIgS AgainsT An otherWISe LethAl challenge of guinEA pIG-", "whitespace_perturbation": ". This virus was attenuate d in vitro  buteve ntu al ly r each ed titers comp a rabl e to those of HPIV3. F ollow in g  INi nf ectio n of gu i ne a pig s,  t his  v i ru s was  hi ghly at tenuated a ndco mpletely res t ri cted to th e r espiratory t rac t butno net h eless  wa s hig hly im m unogen ic. A sin gl e  IN do s e provi d e dcomp lete protection o f  g u inea pigs agai nst an  o t he r w ise  le thal chall en ge of guineap ig - ", "underscore_trick": ". This_virus was_attenuated in vitro but_eventually reached_titers_comparable to_those_of HPIV3. Following_IN infection of_guinea pigs, this virus_was highly attenuated_and_completely restricted to the respiratory tract but nonetheless was highly immunogenic. A single IN_dose_provided complete_protection_of_guinea pigs against an otherwise_lethal challenge of guinea pig-"}
{"text": " with the mammalian syncytin genes that function in trophoblast fusion in placenta formation. This newly acquired retrovirus provides a link between the ancient ERV-L and spumaviruses as well as a connection to the retrovirus Env genes captured as syncytins. This project involves evaluating common human and animal paramyx", "synonym_substitution": "with the mammalian syncytin genes that function in trophoblast fusion in placenta formation. This newly grow retrovirus provide a link between the ancient ERV - L and spumaviruses as well as a connection to the retrovirus Env gene captured as syncytins. This project involves measure common human and animal paramyx", "butter_fingers": " wihh the mammalian syncytik genes that funerion ii trophkblast fjsion in placenta formation. Vhis newlt acquired retrovirus orovides w link bwtwetn the ancient ERT-M and sibmavidmses cs well as a conkection to dhe retrovirus Evv genes captured as syncytins. This pwoject ongolves evaluatyng boimon human and animal paramyx", "random_deletion": "with the mammalian syncytin genes that function fusion placenta formation. newly acquired retrovirus ancient and spumaviruses as as a connection the retrovirus Env genes captured as This project involves evaluating common human and animal paramyx", "change_char_case": " with the mammalian syncytin gEnes that fuNctioN in TroPhOblaSt fuSion in placenta FOrmaTion. This newly acquired rEtrovIrUS proVIdEs a liNk betweEN tHE AncIeNt eRV-l aND sPumavIruSes as weLl as a conneCtiOn To the retroviRUs env genes caPtuRed as syncytiNs. THis proJeCt iNVolveS evAluatIng comMOn humaN and animaL pARamyx", "whitespace_perturbation": " with the mammalian syncyt in genes t hat f unc tio nin t roph oblast fusioni n pl acenta formation. This  newl ya cqui r ed  retr ovirusp ro v i des  a  l ink  b e tw een t heancient  ERV-L and  sp um aviruses asw el l as a con nec tion to theret roviru sEnv genes  ca pture d as s y ncytin s. This p ro j ect in v olves e v a lu atin g common human an d  a n imal paramyx", "underscore_trick": " with_the mammalian_syncytin genes that function_in trophoblast_fusion_in placenta_formation._This newly acquired_retrovirus provides a_link between the ancient_ERV-L and spumaviruses_as_well as a connection to the retrovirus Env genes captured as syncytins. This project_involves_evaluating common_human_and_animal paramyx"}
{"text": " opportunities for new diagnostic capabilities and therapeutic interventions for disorders of puberty and reproduction. We previously reported that 4'-C-cyano-2-amino-2'-deoxyadenosine (CAdA) and 4'-C-cyano-2'-deoxyguanosine (CdG) highly potently", "synonym_substitution": "opportunities for new diagnostic capabilities and therapeutic interposition for disorder of puberty and reproduction. We previously reported that 4'-C - cyano-2 - amino-2'-deoxyadenosine (CAdA) and 4'-C - cyano-2'-deoxyguanosine (CdG) highly potently", "butter_fingers": " opoortunities for new diagkostic capabilitnws and theraleutic ivterventions for disorders oh puverty and reproduction. We pfeviously reportee thet 4'-C-cyano-2-amino-2'-deoxyadenosine (CZfA) aud 4'-C-cyano-2'-deoxygusnosine (CdC) highly potendlh", "random_deletion": "opportunities for new diagnostic capabilities and therapeutic disorders puberty and We previously reported (CdG) potently", "change_char_case": " opportunities for new diagnoStic capabiLitieS anD thErApeuTic iNterventions foR DisoRders of puberty and reproDuctiOn. wE preVIoUsly rEported THaT 4'-c-CyaNo-2-AmIno-2'-DeOXyAdenoSinE (CAdA) anD 4'-C-cyano-2'-deoXygUaNosine (CdG) higHLy Potently", "whitespace_perturbation": " opportunities for new dia gnostic ca pabil iti esan d th erap eutic interven t ions  for disorders of pube rty a nd repr o du ction . We pr e vi o u sly  r ep ort ed th at 4' -C- cyano-2 -amino-2'- deo xy adenosine (C A dA ) and 4'-C -cy ano-2'-deoxy gua nosine  ( CdG )  high lypoten tly", "underscore_trick": " opportunities_for new_diagnostic capabilities and therapeutic_interventions for_disorders_of puberty_and_reproduction. We previously_reported that 4'-C-cyano-2-amino-2'-deoxyadenosine_(CAdA) and 4'-C-cyano-2'-deoxyguanosine (CdG)_highly potently"}
{"text": " the precursor frequency is similar in mice and humans for a given determinant, but humans have many more cells in absolute number that look at each specificity. This new model also proposes that there is a core or ur repertoire that is based on use of germline gene segments in a TCR. This provides the higher affinity receptors (CD", "synonym_substitution": "the precursor frequency is similar in mice and humans for a give deciding, but humans have many more cell in absolute phone number that look at each specificity. This new mannequin besides proposes that there is a core or ur repertoire that is based on manipulation of germline gene segments in a TCR. This provides the gamey affinity receptor (CD", "butter_fingers": " thf precursor frequency is similar in micg qnd hukans fkr a givdn determinant, but humans hate mqny mire cells in absolute vumber thwt look qt eech specificity. Vgis new model wlso 'roposes that tmere is a cmre or ur repestuixe that is based on use of germline dene sebmfnts in a TCR. Jhis krodidea the higher affinity receptors (CD", "random_deletion": "the precursor frequency is similar in mice for given determinant, humans have many that at each specificity. new model also that there is a core or repertoire that is based on use of germline gene segments in a TCR. provides the higher affinity receptors (CD", "change_char_case": " the precursor frequency is siMilar in micE and hUmaNs fOr A givEn deTerminant, but huMAns hAve many more cells in absoLute nUmBEr thAT lOok at Each speCIfICIty. thIs New MoDEl Also pRopOses thaT there is a cOre Or Ur repertoire THaT is based on Use Of germline geNe sEgmentS iN a Tcr. This ProVides The higHEr affiNity recepToRS (CD", "whitespace_perturbation": " the precursor frequency i s similarin mi ceand  h uman s fo r a given dete r mina nt, but humans have ma ny mo re cell s  i n abs olute n u mb e r  th at  l ook  a t  e ach s pec ificity . This new  mo de l also propo s es  that ther e i s a core orurrepert oi ret hat i s b asedon use of ger mline gen es egment s  in a T C R .This  provides the hig h er affinity recep tors ( CD ", "underscore_trick": " the_precursor frequency_is similar in mice_and humans_for_a given_determinant,_but humans have_many more cells_in absolute number that_look at each_specificity._This new model also proposes that there is a core or ur repertoire that_is_based on_use_of_germline gene segments in a_TCR. This provides the higher_affinity receptors_(CD"}
{"text": "adapted EBOV. Lacking the HPIV3 neutralization antigens, HPIV3/delF-HN/EboGP was insensitive to neutralization by HPIV3-specific antibodies in vitro. In addition, there was no significant difference in its immunogenicity in guinea pigs that were HPIV3-na", "synonym_substitution": "adapted EBOV. Lacking the HPIV3 neutralization antigens, HPIV3 / delF - HN / EboGP was insensitive to neutralization by HPIV3 - specific antibodies in vitro. In accession, there be no significant difference in its immunogenicity in guinea slob that were HPIV3 - na", "butter_fingers": "adaoted EBOV. Lacking the HPLV3 neutralizatiou antigxns, HPIB3/delF-HN/EcoGP was insensitive to neutcalizatiob by HPIV3-specific anticodies in vitro. Ib advition, there was no signlyicanf difyecence in its imkunogenicidy in guinea phgr chat were HPIV3-na", "random_deletion": "adapted EBOV. Lacking the HPIV3 neutralization antigens, insensitive neutralization by antibodies in vitro. significant in its immunogenicity guinea pigs that HPIV3-na", "change_char_case": "adapted EBOV. Lacking the HPIV3 NeutralizaTion aNtiGenS, HpIV3/dElF-Hn/EboGP was insenSItivE to neutralization by HPIv3-specIfIC antIBoDies iN vitro. IN AdDITioN, tHeRe wAs NO sIgnifIcaNt diffeRence in its ImmUnOgenicity in gUInEa pigs that WerE HPIV3-na", "whitespace_perturbation": "adapted EBOV. Lacking theHPIV3 neut raliz ati onan tige ns,HPIV3/delF-HN/ E boGP  was insensitive to ne utral iz a tion by  HPIV 3-speci f ic a nti bo di esin vi tro.Inadditio n, there w asno  significant di fference i n i ts immunogen ici ty ingu ine a  pigs  th at we re HPI V 3-na", "underscore_trick": "adapted EBOV._Lacking the_HPIV3 neutralization antigens, HPIV3/delF-HN/EboGP_was insensitive_to_neutralization by_HPIV3-specific_antibodies in vitro._In addition, there_was no significant difference_in its immunogenicity_in_guinea pigs that were HPIV3-na"}
{"text": ", further supporting the validity of the comparative functional genomics approach. Activation of AP-1 transcription factors is a characteristic feature of a HCC subtype expressing hepatoblast traits. The goal of this project was to evaluate the relevance of AP-1 (Jun/Fos) gene expression signature for human HCC. Accomplish", "synonym_substitution": ", further supporting the validity of the comparative running genomics overture. Activation of AP-1 transcription divisor is a characteristic feature of speech of a HCC subtype expressing hepatoblast traits. The goal of this undertaking was to measure the relevance of AP-1 (Jun / Fos) gene expression signature for human HCC. Accomplish", "butter_fingers": ", fugther supporting the valldity of the comkaeative functjonal gevomics approach. Activation oh AP-1 tranwcription factors is a charactegistic feqturt of a HCC subtypx expressing hsiatobnest traits. The noal of thiv project was do eraluate the relevance of AP-1 (Jun/Fos) gqne exptedsion signaturg for rumah HCC. Accomplish", "random_deletion": ", further supporting the validity of the genomics Activation of transcription factors is HCC expressing hepatoblast traits. goal of this was to evaluate the relevance of (Jun/Fos) gene expression signature for human HCC. Accomplish", "change_char_case": ", further supporting the validIty of the coMparaTivE fuNcTionAl geNomics approach. aCtivAtion of AP-1 transcription FactoRs IS a chARaCteriStic feaTUrE OF a HcC SuBtyPe EXpRessiNg hEpatoblAst traits. THe gOaL of this projeCT wAs to evaluaTe tHe relevance oF AP-1 (jun/Fos) GeNe eXPressIon SignaTure foR Human HcC. AccomplIsH", "whitespace_perturbation": ", further supporting the v alidity of  thecom par at ivefunc tional genomic s  app roach. Activation of A P-1 t ra n scri p ti on fa ctors i s  a c har ac te ris ti c  f eatur e o f a HCC  subtype e xpr es sing hepatob l as t traits.The  goal of thi s p roject  w ast o eva lua te th e rele v ance o f AP-1 (J un / Fos) g e ne expr e s si on s ignature for huma n  H C C. Accomplish", "underscore_trick": ", further_supporting the_validity of the comparative_functional genomics_approach._Activation of_AP-1_transcription factors is_a characteristic feature_of a HCC subtype_expressing hepatoblast traits._The_goal of this project was to evaluate the relevance of AP-1 (Jun/Fos) gene expression_signature_for human_HCC._Accomplish"}
{"text": "ids. Mobilized human CD34+ HSPCs isolated from healthy donors were transduced with rAAV6-copGFP and electroporated with pre-formed, ITGB2-targeted Cas9/sgRNA ribonucleoprotein (RNP) complexes. Upon nuclear entry, the ITGB2-ts", "synonym_substitution": "ids. Mobilized human CD34 + HSPCs isolated from healthy donor were transduce with rAAV6 - copGFP and electroporated with pre - formed, ITGB2 - targeted Cas9 / sgRNA ribonucleoprotein (RNP) complex. Upon nuclear submission, the ITGB2 - ts", "butter_fingers": "ids. Mobilized human CD34+ HSPCr isolated from healthb donora were tfansduced with rAAV6-copGFP anv elwctrokjrated with pre-foroed, ITGB2-twrgeted Xas9/sjRNA ribonucleopcktein (RK') comlpexev. Upon nuclear gntry, the ITCB2-ts", "random_deletion": "ids. Mobilized human CD34+ HSPCs isolated from were with rAAV6-copGFP electroporated with pre-formed, Upon entry, the ITGB2-ts", "change_char_case": "ids. Mobilized human CD34+ HSPCs iSolated froM healThy DonOrS werE traNsduced with rAAv6-CopGfP and electroporated witH pre-fOrMEd, ITgb2-tArgetEd Cas9/sgrnA RIBonUcLeOprOtEIn (rNP) coMplExes. UpoN nuclear enTry, ThE ITGB2-ts", "whitespace_perturbation": "ids. Mobilized human CD34+  HSPCs iso lated  fr omhe alth y do nors were tran s duce d with rAAV6-copGFP an d ele ct r opor a te d wit h pre-f o rm e d , I TG B2 -ta rg e te d Cas 9/s gRNA ri bonucleopr ote in  (RNP) compl e xe s. Upon nu cle ar entry, th e I TGB2-t s", "underscore_trick": "ids. Mobilized_human CD34+_HSPCs isolated from healthy_donors were_transduced_with rAAV6-copGFP_and_electroporated with pre-formed,_ITGB2-targeted Cas9/sgRNA ribonucleoprotein_(RNP) complexes. Upon nuclear_entry, the ITGB2-ts"}
{"text": " of depression developed lower 2-hr insulin than those in a health education control group (Delta-16 vs. 16 muIU/mL, P <.05). Further studies are required to determine if adolescents with moderate depression show metabolic benefits after CBT. Another pilot study initiated in 2013 tested if short bouts of activity", "synonym_substitution": "of depression developed lower 2 - hr insulin than those in a health department of education restraint group (Delta-16 vs. 16 muIU / mL, P < .05). Further studies are required to settle if adolescent with moderate depression show metabolic benefits after CBT. Another pilot program study initiated in 2013 test if short bouts of activeness", "butter_fingers": " of depression developed loder 2-hr insulin jhqn thove in z health education control group (Delva-16 vw. 16 muUU/mL, P <.05). Further studier are reqlired to eetecmine if adolescxhts witm modsvate be'ression show mgtabolic benafits after CBD. Xnlther pilot study initiated in 2013 teseed if xhlrt bouts of astivptr", "random_deletion": "of depression developed lower 2-hr insulin than a education control (Delta-16 vs. 16 are to determine if with moderate depression metabolic benefits after CBT. Another pilot initiated in 2013 tested if short bouts of activity", "change_char_case": " of depression developed loweR 2-hr insulin Than tHosE in A hEaltH eduCation control gROup (DElta-16 vs. 16 muIU/mL, P <.05). Further stUdies ArE RequIReD to deTermine IF aDOLesCeNtS wiTh MOdErate DepRession Show metaboLic BeNefits after Cbt. ANother piloT stUdy initiated In 2013 tEsted iF sHorT Bouts Of aCtiviTy", "whitespace_perturbation": " of depression developed l ower 2-hrinsul intha nthos e in  a health educ a tion  control group (Delta- 16 vs .1 6 mu I U/ mL, P  <.05). Fu r t her  s tu die sa re  requ ire d to de termine if  ad ol escents with mo derate dep res sion show me tab olic b en efi t s aft erCBT.Anothe r  pilot  study in it i ated i n  2013 t e s te d if  short bouts of a c ti v ity", "underscore_trick": " of_depression developed_lower 2-hr insulin than_those in_a_health education_control_group (Delta-16 vs._16 muIU/mL, P_<.05). Further studies are_required to determine_if_adolescents with moderate depression show metabolic benefits after CBT. Another pilot study initiated in_2013_tested if_short_bouts_of activity"}
{"text": " quite traumatic. A study evaluating the long term efficacy of the long acting IL-1 inhibitor canakinumab in patients with NOMID is ongoing. 7. The heterogeneous response to IL-1 blockade in patients with AOSD suggests a more complex cause for the inflammatory response in patients with AOSD. 8.", "synonym_substitution": "quite traumatic. A study evaluating the long term efficacy of the retentive act IL-1 inhibitor canakinumab in patients with NOMID is ongoing. 7. The heterogenous response to IL-1 blockade in affected role with AOSD suggests a more complex cause for the incendiary reply in patients with AOSD. 8.", "butter_fingers": " qulte traumatic. A study evxluating the lout term efficzcy of tfe long acting IL-1 inhibitor ranajinumqb in patients with NOOID is onhoing. 7. Tye htterogeneous response to LJ-1 blkgkade mn patients witm AOSD suggasts a more cokpuer cause for the inflammatory responsq in payifnts with AOSD. 8.", "random_deletion": "quite traumatic. A study evaluating the long of long acting inhibitor canakinumab in 7. heterogeneous response to blockade in patients AOSD suggests a more complex cause the inflammatory response in patients with AOSD. 8.", "change_char_case": " quite traumatic. A study evaluAting the loNg terM efFicAcY of tHe loNg acting IL-1 inhiBItor Canakinumab in patients wIth NOmId Is onGOiNg. 7. The HeterogENeOUS reSpOnSe tO Il-1 BlOckadE in PatientS with AOSD sUggEsTs a more complEX cAuse for the InfLammatory resPonSe in paTiEntS With AoSD. 8.", "whitespace_perturbation": " quite traumatic. A studyevaluating  thelon g t er m ef fica cy of the long acti ng IL-1 inhibitor cana kinum ab in p a ti entswith NO M ID i s o ng oi ng.  7 .  T he he ter ogeneou s response  to  I L-1 blockade in  patientswit h AOSD sugge sts  a mor ecom p lex c aus e for  the i n flamma tory resp on s e in p a tientsw i th  AOS D. 8.", "underscore_trick": " quite_traumatic. A_study evaluating the long_term efficacy_of_the long_acting_IL-1 inhibitor canakinumab_in patients with_NOMID is ongoing. 7._The heterogeneous response_to_IL-1 blockade in patients with AOSD suggests a more complex cause for the inflammatory_response_in patients_with_AOSD._8."}
{"text": " Faroe Islands study were about 3-4 times higher than in most other studies, and c) the exposure levels in the two recent U.S. studies were about one third of those in the four earlier U.S. studies or recent Dutch, German, and Northern Quebec studies. Our results will facilitate a direct", "synonym_substitution": "Faroe Islands study were about 3 - 4 times higher than in most early cogitation, and c) the exposure degree in the two late U.S. studies were about one third of those in the four early U.S. studies or recent Dutch, German, and Northern Quebec study. Our results will facilitate a lineal", "butter_fingers": " Fagoe Islands study were anout 3-4 times highgr than mn most other sgudies, and c) the exposure letels in tye two recent U.S. studids were ahout one thicd of those in tis four ccrlied U.S. vvudies or recenj Dutch, Germdn, and Northert Duzbec studies. Our results will facilieate a cigect", "random_deletion": "Faroe Islands study were about 3-4 times in other studies, c) the exposure U.S. were about one of those in four earlier U.S. studies or recent German, and Northern Quebec studies. Our results will facilitate a direct", "change_char_case": " Faroe Islands study were abouT 3-4 times highEr thaN in MosT oTher StudIes, and c) the expoSUre lEvels in the two recent U.S. sTudieS wERe abOUt One thIrd of thOSe IN The FoUr EarLiER U.s. studIes Or recenT Dutch, GermAn, aNd northern QuebEC sTudies. Our rEsuLts will facilItaTe a dirEcT", "whitespace_perturbation": " Faroe Islands study wereabout 3-4times  hi ghe rthan  inmost other stu d ies,  and c) the exposure l evels  i n  the tw o rec ent U.S .  s t u die swe reab o ut  onethi rd of t hose in th e f ou r earlier U. S .studies or  re cent Dutch,Ger man, a nd  No r thern  Qu ebecstudie s . Ourresults w il l  facil i tate ad i re ct", "underscore_trick": " Faroe_Islands study_were about 3-4 times_higher than_in_most other_studies,_and c) the_exposure levels in_the two recent U.S._studies were about_one_third of those in the four earlier U.S. studies or recent Dutch, German, and_Northern_Quebec studies._Our_results_will facilitate a direct"}
{"text": " spheroids and are we assessing EpCAM-function in the these model system. We have observed a dramatic phenotype that can be reversed to large extent by treatment with a single pharmacologic inhibitor. The mechanism(s) that are responsible for this effect are under investigation, but our studies clearly argue for an important role in", "synonym_substitution": "spheroids and are we assessing EpCAM - function in the these model arrangement. We have observe a dramatic phenotype that can be reversed to big extent by discussion with a single pharmacologic inhibitor. The mechanism(s) that are responsible for this consequence are under investigation, but our studies intelligibly argue for an important role in", "butter_fingers": " spjeroids and are we assesring EpCAM-functnin in vhe theae model system. We have observed a dcamaric pyenotype that can be rdversed tl large wxteit by treatment xjth a slugle lmarmaeooogic inhibitot. The mechanhsm(s) that are serplnsible for this effect are under igvestigstlon, but our stodies sleadly argue for an important role in", "random_deletion": "spheroids and are we assessing EpCAM-function in model We have a dramatic phenotype large by treatment with single pharmacologic inhibitor. mechanism(s) that are responsible for this are under investigation, but our studies clearly argue for an important role in", "change_char_case": " spheroids and are we assessinG EpCAM-funcTion iN thE thEsE modEl syStem. We have obseRVed a Dramatic phenotype that cAn be rEvERsed TO lArge eXtent by TReATMenT wItH a sInGLe PharmAcoLogic inHibitor. The MecHaNism(s) that are REsPonsible foR thIs effect are uNdeR invesTiGatIOn, but Our StudiEs cleaRLy arguE for an impOrTAnt rolE In", "whitespace_perturbation": " spheroids and are we asse ssing EpCA M-fun cti onin  the  the se model syste m . We  have observed a drama tic p he n otyp e  t hat c an be r e ve r s edto  l arg ee xt ent b y t reatmen t with a s ing le  pharmacolog i cinhibitor.  Th e mechanism( s)that a re  re s ponsi ble  forthis e f fect a re underin v estiga t ion, bu t ou r st udies clearly arg u ef or an importan t role  i n ", "underscore_trick": " spheroids_and are_we assessing EpCAM-function in_the these_model_system. We_have_observed a dramatic_phenotype that can_be reversed to large_extent by treatment_with_a single pharmacologic inhibitor. The mechanism(s) that are responsible for this effect are under_investigation,_but our_studies_clearly_argue for an important role_in"}
{"text": "ain contains three cysteine residues, each of which can contribute to the formation of cysteine-linked dimers. In FY13 we started to determine the importance of the positioning of the cysteine bridge for BST-2 function. Starting with a cysteine-free monomeric form of BST-2, individual cysteine residues were re", "synonym_substitution": "ain contains three cysteine residues, each of which can contribute to the formation of cysteine - connect dimer. In FY13 we started to determine the importance of the placement of the cysteine bridge for BST-2 function. start with a cysteine - free monomeric form of BST-2, individual cysteine residue were re", "butter_fingers": "ain contains three cysteine residues, each of whici can ckntributd to the formation of cysteiie-libked eimers. In FY13 we startea to detegmine the impietance of vge posibnoninf of chx cysteine bridne for BST-2 xunction. Starthne cith a cysteine-free monomeric form os BST-2, imdlvidual cysteige rtsiques were re", "random_deletion": "ain contains three cysteine residues, each of contribute the formation cysteine-linked dimers. In the of the positioning the cysteine bridge BST-2 function. Starting with a cysteine-free form of BST-2, individual cysteine residues were re", "change_char_case": "ain contains three cysteine rEsidues, eacH of whIch Can CoNtriBute To the formation OF cysTeine-linked dimers. In FY13 wE starTeD To deTErMine tHe imporTAnCE Of tHe PoSitIoNInG of thE cySteine bRidge for BSt-2 fuNcTion. Starting WItH a cysteine-FreE monomeric foRm oF BST-2, inDiVidUAl cysTeiNe resIdues wERe re", "whitespace_perturbation": "ain contains three cystein e residues , eac h o f w hi ch c an c ontribute to t h e fo rmation of cysteine-li nkeddi m ers. In  FY13  we sta r te d tode te rmi ne th e imp ort ance of  the posit ion in g of the cys t ei ne bridgefor  BST-2 funct ion . Star ti ngw ith a  cy stein e-free monome ric formof BST-2, individ u a lcyst eine residues wer e  r e ", "underscore_trick": "ain contains_three cysteine_residues, each of which_can contribute_to_the formation_of_cysteine-linked dimers. In_FY13 we started_to determine the importance_of the positioning_of_the cysteine bridge for BST-2 function. Starting with a cysteine-free monomeric form of BST-2,_individual_cysteine residues_were_re"}
{"text": " induced only a slight reduction of CXCR4 at the cell surface, the residual receptor was profoundly impaired for chemotaxis and ligand mediated receptor internalization. The chemotactic defect resulted from inhibition of early signaling steps such as dissociation of G-protein subunits, intracellular Ca++ flux, polarized accumulation of pAKT, F-actin polymers", "synonym_substitution": "induced only a slight reduction of CXCR4 at the cellular telephone open, the residual receptor was profoundly impaired for chemotaxis and ligand intercede sense organ internalization. The chemotactic defect resulted from inhibition of early signaling step such as dissociation of G - protein subunits, intracellular Ca++ flux, polarize accumulation of pAKT, F - actin polymers", "butter_fingers": " infuced only a slight redugtion of CXCR4 at the cenl surrace, the residual receptor was profonndlt impqired for chemotaxis avd ligand mediatee rereptor internalivztion. Tmz chejltaccir defect resultgd from inhitition of earlf riynaling steps such as dissociation os G-protrij subunits, inttacelktlar Ba++ flux, polarized accumulation kf pAKT, F-actin polymrrs", "random_deletion": "induced only a slight reduction of CXCR4 cell the residual was profoundly impaired receptor The chemotactic defect from inhibition of signaling steps such as dissociation of subunits, intracellular Ca++ flux, polarized accumulation of pAKT, F-actin polymers", "change_char_case": " induced only a slight reductiOn of CXCR4 at The ceLl sUrfAcE, the ResiDual receptor waS ProfOundly impaired for chemoTaxis AnD LigaND mEdiatEd recepTOr INTerNaLiZatIoN. thE chemOtaCtic defEct resulteD frOm Inhibition of EArLy signalinG stEps such as disSocIation Of g-prOTein sUbuNits, iNtraceLLular CA++ flux, polaRiZEd accuMUlation OF PAkT, F-aCtin polymers", "whitespace_perturbation": " induced only a slight red uction ofCXCR4  at  th ecell  sur face, the resi d ualreceptor was profoundl y imp ai r ed f o rchemo taxis a n dl i gan dme dia te d  r ecept orinterna lization.The  c hemotactic d e fe ct resulte d f rom inhibiti onof ear ly  si g nalin g s tepssuch a s  disso ciation o fG -prote i n subun i t s,  int racellular Ca++ f l ux ,  polarized acc umulat io n  o f pAK T,F-actin po ly mers", "underscore_trick": " induced_only a_slight reduction of CXCR4_at the_cell_surface, the_residual_receptor was profoundly_impaired for chemotaxis_and ligand mediated receptor_internalization. The chemotactic_defect_resulted from inhibition of early signaling steps such as dissociation of G-protein subunits, intracellular_Ca++_flux, polarized_accumulation_of_pAKT, F-actin polymers"}
{"text": ". To determine how FA protein composition is globally modulated by myosinII contraction, we developed a proteomics approach to isolate native FAs, identify their protein composition, and compare specific protein abundance in FAs from cells with and without myosinII inhibition. We reproducibly identified 905 FA-associated proteins, half (402)", "synonym_substitution": ". To determine how FA protein composition is globally modulated by myosinII contraction, we develop a proteomics overture to isolate native FAs, identify their protein musical composition, and compare specific protein abundance in FAs from cells with and without myosinII prohibition. We reproducibly identified 905 FA - associated proteins, one-half (402 )", "butter_fingers": ". To determine how FA proteik composition is globalny modhlated bh myosinII contraction, we deteloped a proteomics approach tu isolate native DAs, mdentify their pcktein composiflon, aud compare specinic protein abundance in XAr yrom cells with and without myosinII inhibiyiln. We reproducybly ydenfpfled 905 FA-associated proteins, half (402)", "random_deletion": ". To determine how FA protein composition modulated myosinII contraction, developed a proteomics identify protein composition, and specific protein abundance FAs from cells with and without inhibition. We reproducibly identified 905 FA-associated proteins, half (402)", "change_char_case": ". To determine how FA protein coMposition iS globAllY moDuLateD by mYosinII contracTIon, wE developed a proteomics aPproaCh TO isoLAtE natiVe FAs, idENtIFY thEiR pRotEiN CoMposiTioN, and comPare specifIc pRoTein abundancE In fAs from celLs wIth and withouT myOsinII InHibITion. WE reProduCibly iDEntifiEd 905 FA-assocIaTEd protEIns, half (402)", "whitespace_perturbation": ". To determine how FA prot ein compos ition  is  gl ob ally  mod ulated by myos i nIIcontraction, we develo ped a  p r oteo m ic s app roach t o  i s o lat ena tiv eF As , ide nti fy thei r proteincom po sition, andc om pare speci fic  protein abu nda nce in  F Asf rom c ell s wit h andw ithout  myosinII  i n hibiti o n. We r e p ro duci bly identified 90 5  F A -associated pr oteins ,h al f (40 2)", "underscore_trick": ". To_determine how_FA protein composition is_globally modulated_by_myosinII contraction,_we_developed a proteomics_approach to isolate_native FAs, identify their_protein composition, and_compare_specific protein abundance in FAs from cells with and without myosinII inhibition. We reproducibly_identified_905 FA-associated_proteins,_half_(402)"}
{"text": " the organ- specific immune responses downstream of IL-1 and may shed light on processes that determine specific organ manifestations. 6. The development of long acting IL-1 inhibitors may allow for better disease control in those patients who are not in complete remission and offer more convenient treatment options particularly in children in whom daily injections can be", "synonym_substitution": "the organ- specific immune responses downstream of IL-1 and may shed light on processes that settle specific electric organ manifestations. 6. The development of long act IL-1 inhibitors may allow for good disease control in those patients who are not in accomplished remission and offer more commodious treatment options particularly in children in whom casual injections can be", "butter_fingers": " thf organ- specific immune vesponses downstteqm of ML-1 and jay shed light on processes that detxrmibe sptbific organ manifestagions. 6. Thv developnent if long acvjng IL-1 luhibiflrs key allow for bejter disease control in thmsd 'atients who are not in complete remyssion snf offer more cjnvemyent nrtatment options particularly in cgildren in whom dailu injections can be", "random_deletion": "the organ- specific immune responses downstream of may light on that determine specific of acting IL-1 inhibitors allow for better control in those patients who are in complete remission and offer more convenient treatment options particularly in children in daily injections can be", "change_char_case": " the organ- specific immune resPonses downStreaM of iL-1 aNd May sHed lIght on processeS That Determine specific organ ManifEsTAtioNS. 6. THe devElopmenT Of LONg aCtInG IL-1 InHIbItors May Allow foR better disEasE cOntrol in thosE PaTients who aRe nOt in complete RemIssion AnD ofFEr morE coNveniEnt treATment oPtions parTiCUlarly IN childrEN In Whom Daily injections caN Be", "whitespace_perturbation": " the organ- specific immun e response s dow nst rea mof I L-1and may shed l i ghton processes that dete rmine  s p ecif i corgan  manife s ta t i ons .6.  Th ed ev elopm ent  of lon g acting I L-1  i nhibitors ma y  a llow for b ett er disease c ont rol in  t hos e  pati ent s who  are n o t in c omplete r em i ssiona nd offe r mo re c onvenient treatme n to ptions particu larlyin ch i l dre n i n whom dai ly  inje c tions c a nb e ", "underscore_trick": " the_organ- specific_immune responses downstream of_IL-1 and_may_shed light_on_processes that determine_specific organ manifestations._6. The development of_long acting IL-1_inhibitors_may allow for better disease control in those patients who are not in complete_remission_and offer_more_convenient_treatment options particularly in children_in whom daily injections can_be"}
{"text": " in individual response to training, including such factors as low cognitive function, cardiovascular status, engagement, and ApoE genotype. 4) To estimate and project the effects of ACTIVE training to the general population of older adults by linking the measures and outcomes of ACTIVE to the Health and Retirement Study. This application aff", "synonym_substitution": "in individual response to training, including such factors as depleted cognitive affair, cardiovascular status, engagement, and ApoE genotype. 4) To estimate and project the impression of ACTIVE training to the general population of old adults by linking the measure and outcomes of ACTIVE to the Health and Retirement Study. This application aff", "butter_fingers": " in individual response to uraining, includiny such hactors as low zognitive function, cardiovasrulae stauls, engagement, and ApoD genotypv. 4) To estumatt and project the effects of ACFLVE txamning to the gekeral populdtion of older aaupts by linking the measures and outsomes og WCTIVE to the Realuh wnd Dvtlrement Study. This application arf", "random_deletion": "in individual response to training, including such low function, cardiovascular engagement, and ApoE project effects of ACTIVE to the general of older adults by linking the and outcomes of ACTIVE to the Health and Retirement Study. This application aff", "change_char_case": " in individual response to traIning, incluDing sUch FacToRs as Low cOgnitive functiON, carDiovascular status, engagEment, AnD apoE GEnOtype. 4) to estimATe AND prOjEcT thE eFFeCts of aCTiVE traiNing to the gEneRaL population oF OlDer adults bY liNking the measUreS and ouTcOmeS Of ACTiVE To the health ANd RetiRement StuDy. tHis appLIcation AFF", "whitespace_perturbation": " in individual response to  training,  incl udi ngsu ch f acto rs as low cogn i tive  function, cardiovascu lar s ta t us,e ng ageme nt, and Ap o E  ge no ty pe.  4 )  T o est ima te andproject th e e ff ects of ACTI V Etraining t o t he general p opu lation  o f o l der a dul ts by  linki n g themeasuresan d  outco m es of A C T IV E to  the Health and R e ti r ement Study. T his ap pl i ca t i onaff ", "underscore_trick": " in_individual response_to training, including such_factors as_low_cognitive function,_cardiovascular_status, engagement, and_ApoE genotype. 4)_To estimate and project_the effects of_ACTIVE_training to the general population of older adults by linking the measures and outcomes_of_ACTIVE to_the_Health_and Retirement Study. This application_aff"}
{"text": "-2. We expect to complete this project in FY14. SAMHD1/Vpx: In FY12 we initiated a new project involving the functional characterization of SAMHD1 is a dNTPase that presumably reduces the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. However", "synonym_substitution": "-2. We expect to complete this project in FY14. SAMHD1 / Vpx: In FY12 we initiated a newfangled undertaking involving the functional word picture of SAMHD1 is a dNTPase that presumably reduce the cellular dNTP levels to levels besides broken for retroviral reverse arrangement to occur. However", "butter_fingers": "-2. We expect to complete this project in FY14. SAMHD1/Vpe: In FY12 we initkated a new project involvinj thw funxtional characterizatiun of SAMJD1 is a eNTPese that presumaumy redugzs ths celnnlar dNTP levelx to levelv too low for segrlviral reverse transcription to occtr. Howefeg", "random_deletion": "-2. We expect to complete this project SAMHD1/Vpx: FY12 we a new project SAMHD1 a dNTPase that reduces the cellular levels to levels too low for reverse transcription to occur. However", "change_char_case": "-2. We expect to complete this proJect in FY14. SAmHD1/VpX: In fY12 wE iNitiAted A new project invOLvinG the functional characteRizatIoN Of SAmhD1 Is a dNtPase thAT pRESumAbLy RedUcES tHe celLulAr dNTP lEvels to levEls ToO low for retroVIrAl reverse tRanScription to oCcuR. HowevEr", "whitespace_perturbation": "-2. We expect to completethis proje ct in  FY 14.  S AMHD 1/Vp x: In FY12 wei niti ated a new project inv olvin gt he f u nc tiona l chara c te r i zat io nofSA M HD 1 isa d NTPasethat presu mab ly  reduces the ce llular dNT P l evels to lev els  too l ow  fo r  retr ovi ral r everse transc ription t oo ccur.H owever", "underscore_trick": "-2. We_expect to_complete this project in_FY14. SAMHD1/Vpx:_In_FY12 we_initiated_a new project_involving the functional_characterization of SAMHD1 is_a dNTPase that_presumably_reduces the cellular dNTP levels to levels too low for retroviral reverse transcription to_occur._However"}
{"text": "arial infections are studded with filarial antigen and express markers associated with alternative activation of macrophages (M&#934;). To explore the role of filaria-derived parasite antigen in differentiation of human monocytes, cells were exposed to microfilariae (mf) of Brugia malayi, and their phenotypic", "synonym_substitution": "arial infections are studded with filarial antigen and express markers consociate with alternate activation of macrophages (M&#934 ;). To research the role of filaria - derive parasite antigen in specialization of human monocytes, cells were exposed to microfilariae (mf) of Brugia malayi, and their phenotypic", "butter_fingers": "ariwl infections are studdea with filarial antigei and espress mxrkers associated with alteriatice acupvation of macrophager (M&#934;). To exilore the rolt of filaria-derivxs paraslce anflgen nn differentiatipn of humat monocytes, cenlr cere exposed to microfilariae (mf) of Frugia kapayi, and their phemjtypjb", "random_deletion": "arial infections are studded with filarial antigen markers with alternative of macrophages (M&#934;). filaria-derived antigen in differentiation human monocytes, cells exposed to microfilariae (mf) of Brugia and their phenotypic", "change_char_case": "arial infections are studded With filariAl antIgeN anD eXpreSs maRkers associateD With Alternative activation oF macrOpHAges (m&#934;). to ExploRe the roLE oF FIlaRiA-dEriVeD PaRasitE anTigen in DifferentiAtiOn Of human monocYTeS, cells were ExpOsed to microfIlaRiae (mf) Of bruGIa malAyi, And thEir pheNOtypic", "whitespace_perturbation": "arial infections are studd ed with fi laria l a nti ge n an d ex press markersa ssoc iated with alternative  acti va t iono fmacro phages( M& # 9 34; ).  T o e xp l or e the  ro le of f ilaria-der ive dparasite ant i ge n in diffe ren tiation of h uma n mono cy tes ,  cell s w ere e xposed to mic rofilaria e( mf) of Brugiam a la yi,and their phenoty p ic ", "underscore_trick": "arial infections_are studded_with filarial antigen and_express markers_associated_with alternative_activation_of macrophages (M&#934;)._To explore the_role of filaria-derived parasite_antigen in differentiation_of_human monocytes, cells were exposed to microfilariae (mf) of Brugia malayi, and their phenotypic"}
{"text": " 5 years. 3. Chronic inflammation leads to growth retardation, osteoporosis. We showed that bone mineral density increases above the age-expected increase which correlate with a change in bone markers suggesting an increase in bone production and catch-up height and weight gains are seen in treated patients. 4. An ongoing study in patients with N", "synonym_substitution": "5 years. 3. Chronic inflammation leads to growth slowdown, osteoporosis. We usher that bone mineral density increases above the age - ask increase which correlate with a change in bone marker suggesting an increase in bone product and catch - up height and weight unit gains are seen in regale patient. 4. An ongoing study in patients with N", "butter_fingers": " 5 yfars. 3. Chronic inflammatiun leads to grocrh reterdatioh, osteopurosis. We showed that bone mmnerql debsity increases above ghe age-exiected inxreaww which cocdelate with a ghangz mn bone markers suggestinc an increase hn blne production and catch-up height agd weignt gains are seeg in ereafvd patients. 4. An ongoing study ih patieits with N", "random_deletion": "5 years. 3. Chronic inflammation leads to osteoporosis. showed that mineral density increases correlate a change in markers suggesting an in bone production and catch-up height weight gains are seen in treated patients. 4. An ongoing study in patients N", "change_char_case": " 5 years. 3. Chronic inflammation lEads to growTh retArdAtiOn, OsteOporOsis. We showed thAT bonE mineral density increasEs aboVe THe agE-ExPecteD increaSE wHICh cOrReLatE wITh A chanGe iN bone maRkers suggeStiNg An increase in BOnE productioN anD catch-up heigHt aNd weigHt GaiNS are sEen In treAted paTIents. 4. AN ongoing sTuDY in patIEnts witH n", "whitespace_perturbation": " 5 years. 3. Chronic infla mmation le ads t o g row th  ret arda tion, osteopor o sis.  We showed that bone m inera ld ensi t yincre ases ab o ve t heag e- exp ec t ed  incr eas e which  correlate  wi th  a change in bo ne markers  su ggesting aninc reasein  bo n e pro duc tionand ca t ch-upheight an dw eightg ains ar e se en i n treated patient s .4 . An ongoing s tudy i np at i e nts  wi th N", "underscore_trick": " 5_years. 3._Chronic inflammation leads to_growth retardation,_osteoporosis._We showed_that_bone mineral density_increases above the_age-expected increase which correlate_with a change_in_bone markers suggesting an increase in bone production and catch-up height and weight gains_are_seen in_treated_patients._4. An ongoing study in_patients with N"}
{"text": "ive versus HPIV3-immune. Thus, HPIV3/delF-HN/EboGP provides an alternative to HPIV3/EboGP that is very highly attenuated, is insensitive to HPIV3-neutralizing antibodies, and nonetheless is nearly as immunogenic. We also are investigating the use", "synonym_substitution": "i ve versus HPIV3 - immune. Thus, HPIV3 / delF - HN / EboGP provides an alternative to HPIV3 / EboGP that is very highly attenuated, is insensitive to HPIV3 - counteract antibody, and nonetheless is nearly equally immunogenic. We also are investigate the use", "butter_fingers": "ive versus HPIV3-immune. Thus, MPIV3/delF-HN/EboGP krivides an alfernativd to HPIV3/EboGP that is very iighoy atuvnuated, is insensitivd to HPIV3-jeutralizing qntibodies, and noncchelead is iearly as immunpgenic. We dlso are invesdieacing the use", "random_deletion": "ive versus HPIV3-immune. Thus, HPIV3/delF-HN/EboGP provides an HPIV3/EboGP is very attenuated, is insensitive is as immunogenic. We are investigating the", "change_char_case": "ive versus HPIV3-immune. Thus, HPiV3/delF-HN/EbOGP prOviDes An AlteRnatIve to HPIV3/EboGP THat iS very highly attenuated, iS inseNsITive TO HpIV3-neUtralizINg ANTibOdIeS, anD nONeTheleSs iS nearly As immunogeNic. we Also are invesTIgAting the usE", "whitespace_perturbation": "ive versus HPIV3-immune. T hus, HPIV3 /delF -HN /Eb oG P pr ovid es an alternat i ve t o HPIV3/EboGP that isveryhi g hlya tt enuat ed, isi ns e n sit iv etoHP I V3 -neut ral izing a ntibodies,  an dnonethelessi snearly asimm unogenic. We  al so are  i nve s tigat ing  theuse", "underscore_trick": "ive versus_HPIV3-immune. Thus,_HPIV3/delF-HN/EboGP provides an alternative_to HPIV3/EboGP_that_is very_highly_attenuated, is insensitive_to HPIV3-neutralizing antibodies,_and nonetheless is nearly_as immunogenic. We_also_are investigating the use"}
{"text": " at a dose of 1 mg/kg/day, showed essentially no reduction in the HBVETV-RL180M/S202G/M204V viremia levels. By contrast, CMCP at the same dose of 1 mg/kg/day, brought about a significant level of viremia reduction", "synonym_substitution": "at a dose of 1 mg / kg / day, showed essentially no decrease in the HBVETV - RL180M / S202G / M204V viremia degree. By contrast, CMCP at the same venereal disease of 1 mg / kg / sidereal day, brought about a significant level of viremia decrease", "butter_fingers": " at a dose of 1 mg/kg/day, showtd essentially no reductmon in fhe HBVEGV-RL180M/S202G/M204V viremia levels. By ronteast, XMCP at the same dose uf 1 mg/kg/dwy, brougyt auout a significaif level of vidcmia xevuction", "random_deletion": "at a dose of 1 mg/kg/day, showed reduction the HBVETV-RL180M/S202G/M204V levels. By contrast, of mg/kg/day, brought about significant level of reduction", "change_char_case": " at a dose of 1 mg/kg/day, showed essEntially no ReducTioN in ThE HBVeTV-Rl180M/S202G/M204V viremia lEVels. by contrast, CMCP at the samE dose Of 1 MG/kg/dAY, bRoughT about a SIgNIFicAnT lEveL oF ViRemia RedUction", "whitespace_perturbation": " at a dose of 1 mg/kg/day,  showed es senti all y n oredu ctio n in the HBVET V -RL1 80M/S202G/M204V viremi a lev el s . By co ntras t, CMCP at t hesa me  do se of  1 mg /kg /day, b rought abo utasignificantl ev el of vire mia  reduction", "underscore_trick": " at_a dose_of 1 mg/kg/day, showed_essentially no_reduction_in the_HBVETV-RL180M/S202G/M204V_viremia levels. By_contrast, CMCP at_the same dose of_1 mg/kg/day, brought_about_a significant level of viremia reduction"}
{"text": "A, we have begun to develop a family health history assessment tool called Families SHARE (Sharing Health Assessments and Risk Evaluation). It is anticipated that this tool will be used by a family genomics health educator to disseminate family risk information to their first and second degree relatives and encourage risk reducing behaviors.", "synonym_substitution": "A, we have begun to develop a family health history appraisal cock called Families SHARE (Sharing Health assessment and Risk Evaluation). It is anticipated that this tool will be use by a kin genomics health educator to disseminate family risk information to their beginning and second degree relatives and promote risk reducing behaviors.", "butter_fingers": "A, wf have begun to develop x family health historb assesament toul called Families SHARE (Shacing Healuk Assessments and Rirk Evaluanion). It iw anuicipated that thma tool will bs useb uy a family genpmics healdh educator to dksdeminate family risk information to their gigst and second deggeq rematives and encourage risk reducinf behavpors.", "random_deletion": "A, we have begun to develop a history tool called SHARE (Sharing Health is that this tool be used by family genomics health educator to disseminate risk information to their first and second degree relatives and encourage risk reducing", "change_char_case": "A, we have begun to develop a famIly health hIstorY asSesSmEnt tOol cAlled Families ShaRE (SHaring Health AssessmentS and RIsK evalUAtIon). It Is anticIPaTED thAt ThIs tOoL WiLl be uSed By a famiLy genomics HeaLtH educator to dISsEminate famIly Risk informatIon To theiR fIrsT And seConD degrEe relaTIves anD encouragE rISk reduCIng behaVIOrS.", "whitespace_perturbation": "A, we have begun to develo p a family  heal thhis to ry a sses sment tool cal l ed F amilies SHARE (Sharing  Heal th Asse s sm entsand Ris k  E v a lua ti on ).It is  anti cip ated th at this to olwi ll be used b y  a  family ge nom ics health e duc ator t odis s emina tefamil y risk inform ation toth e ir fir s t and s e c on d de gree relatives an d  e n courage risk r educin gb eh a v ior s.", "underscore_trick": "A, we_have begun_to develop a family_health history_assessment_tool called_Families_SHARE (Sharing Health_Assessments and Risk_Evaluation). It is anticipated_that this tool_will_be used by a family genomics health educator to disseminate family risk information to_their_first and_second_degree_relatives and encourage risk reducing_behaviors."}
{"text": " and Met-deficient primary mouse hepatocytes. Novel transcriptional targets of Met pathway were identified that included genes involved in the regulation of oxidative stress responses as well as cell motility, cytoskeletal organization, and angiogenesis. To assess the importance of Met-regulated gene expression signature, a comparative functional genomics approach was applied to 242 human HCC", "synonym_substitution": "and Met - deficient primary mouse hepatocytes. Novel transcriptional target of Met nerve pathway were identified that included gene involved in the rule of oxidative stress responses equally well as cell motility, cytoskeletal organization, and angiogenesis. To measure the importance of Met - regulated gene expression key signature, a comparative functional genomics approach path was practice to 242 human HCC", "butter_fingers": " anf Met-deficient primary muuse hepatocytes. Novel transdriptionxl targets of Met pathway wece ieentidied that included gends involvvd in the regnlation of oxidavjve strcfs rsdponvxs as well as cgll motility, cytoskeletal mreauization, and angiogenesis. To assess ehe impprhance of Met-redulaued gens expression signature, a comparatibe funcuional genomics aplroach was applied to 242 humwn HFC", "random_deletion": "and Met-deficient primary mouse hepatocytes. Novel transcriptional Met were identified included genes involved stress as well as motility, cytoskeletal organization, angiogenesis. To assess the importance of gene expression signature, a comparative functional genomics approach was applied to 242 human", "change_char_case": " and Met-deficient primary mouSe hepatocyTes. NoVel TraNsCripTionAl targets of Met PAthwAy were identified that inCludeD gENes iNVoLved iN the regULaTIOn oF oXiDatIvE StRess rEspOnses as Well as cell MotIlIty, cytoskeleTAl OrganizatiOn, aNd angiogenesIs. TO assesS tHe iMPortaNce Of Met-RegulaTEd gene ExpressioN sIGnaturE, A comparATIvE funCtional genomics apPRoACh was applied to 242 Human HcC", "whitespace_perturbation": " and Met-deficient primary  mouse hep atocy tes . N ov el t rans criptional tar g etsof Met pathway were id entif ie d  tha t  i nclud ed gene s  i n v olv ed  i n t he re gulat ion  of oxi dative str ess  r esponses asw el l as cellmot ility, cytos kel etal o rg ani z ation , a nd an giogen e sis. T o assessth e  impor t ance of M et -reg ulated gene expre s si o n signature, a  compa ra t iv e fun cti onal genom ic s app r oach wa s  a p p l ied to 242 humanHCC", "underscore_trick": " and_Met-deficient primary_mouse hepatocytes. Novel transcriptional_targets of_Met_pathway were_identified_that included genes_involved in the_regulation of oxidative stress_responses as well_as_cell motility, cytoskeletal organization, and angiogenesis. To assess the importance of Met-regulated gene expression_signature,_a comparative_functional_genomics_approach was applied to 242_human HCC"}
{"text": " published in the Journal of Investigative Dermatology. Our interpretation of the our seeming disparate results using mice whose Langerhans cells lack EpCAM is that the role that EpCAM plays in the regulation of Langerhans cells is context dependent. We have also explored mechanisms by which EpCAM regulates intercellular", "synonym_substitution": "published in the Journal of Investigative Dermatology. Our interpretation of the our seeming disparate results use mouse whose Langerhans cells lack EpCAM is that the role that EpCAM play in the regulation of Langerhans cells is context subject. We have besides explored mechanisms by which EpCAM regulates intercellular", "butter_fingers": " puhlished in the Journal on Investigative Bwrmatonogy. Ohr interoretation of the our seeming dusparqte results using mice whose Lajgerhans celow lack EpCEJ is that the vole chet EpCAM plays ln the regunation of Langarfaus cells is context dependent. We havq also rxolored mechanifms nr whjbh EpCAM regulates intercellulad", "random_deletion": "published in the Journal of Investigative Dermatology. of our seeming results using mice is the role that plays in the of Langerhans cells is context dependent. have also explored mechanisms by which EpCAM regulates intercellular", "change_char_case": " published in the Journal of InVestigativE DermAtoLogY. OUr inTerpRetation of the oUR seeMing disparate results usIng miCe WHose lAnGerhaNs cells LAcK ePCAm iS tHat ThE RoLe thaT EpcAM playS in the reguLatIoN of LangerhanS CeLls is conteXt dEpendent. We haVe aLso expLoRed MEchanIsmS by whIch EpCam regulAtes interCeLLular", "whitespace_perturbation": " published in the Journalof Investi gativ e D erm at olog y. O ur interpretat i on o f the our seeming disp arate  r e sult s  u singmice wh o se L ang er ha nsce l ls  lack  Ep CAM isthat the r ole  t hat EpCAM pl a ys  in the re gul ation of Lan ger hans c el lsi s con tex t dep endent .  We ha ve also e xp l ored m e chanism s by  whi ch EpCAM regulate s  i n tercellular", "underscore_trick": " published_in the_Journal of Investigative Dermatology._Our interpretation_of_the our_seeming_disparate results using_mice whose Langerhans_cells lack EpCAM is_that the role_that_EpCAM plays in the regulation of Langerhans cells is context dependent. We have also_explored_mechanisms by_which_EpCAM_regulates intercellular"}
{"text": " completed coding the annual follow-up CEGRMs for future analyses. We continue to consider how families communicate about, experience, and cope with inherited conditions. We have established an Umbrella Protocol that allows us to examine these processes in ongoing studies (NHGRI Protocol #12-HG-N149; PI:", "synonym_substitution": "completed coding the annual follow - up CEGRMs for future analyses. We stay to think how families communicate about, experience, and cope with inherited condition. We have established an Umbrella Protocol that allows us to analyze these processes in ongoing studies (NHGRI Protocol # 12 - HG - N149; PI:", "butter_fingers": " colpleted coding the annuau follow-up CEGRMs for huture znalyses. We continue to consider how fqmilitf communicate aboug, experiejce, and xope qith inhermfed conditiona. We kate established sn Umbrelld Protocol thad xlpows us to examine these processes yn ongoonh studies (NHGRY Prpeocom #12-HG-N149; PI:", "random_deletion": "completed coding the annual follow-up CEGRMs for We to consider families communicate about, conditions. have established an Protocol that allows to examine these processes in ongoing (NHGRI Protocol #12-HG-N149; PI:", "change_char_case": " completed coding the annual fOllow-up CEGrMs foR fuTurE aNalySes. WE continue to conSIder How families communicate About, ExPErieNCe, And coPe with iNHeRITed CoNdItiOnS. we Have eStaBlished An Umbrella proToCol that allowS Us To examine tHesE processes in OngOing stUdIes (nhGRI PRotOcol #12-Hg-N149; PI:", "whitespace_perturbation": " completed coding the annu al follow- up CE GRM s f or  fut ureanalyses. We c o ntin ue to consider how fam ilies  c o mmun i ca te ab out, ex p er i e nce ,an d c op e  w ith i nhe rited c onditions.  We  h ave establis h ed  an Umbrel laProtocol tha t a llowsus  to exami nethese  proce s ses in  ongoingst u dies ( N HGRI Pr o t oc ol # 12-HG-N149; PI:", "underscore_trick": " completed_coding the_annual follow-up CEGRMs for_future analyses._We_continue to_consider_how families communicate_about, experience, and_cope with inherited conditions._We have established_an_Umbrella Protocol that allows us to examine these processes in ongoing studies (NHGRI Protocol_#12-HG-N149;_PI:"}
{"text": " filarial-infected patients. These data provide clues to the pathways induced by infection and those systemic alterations seen in chronic helminth infection. A longstanding issue in environmental health is the need to understand the role the environment plays in human brain development. The brain of the neonate is particularly susceptible to disruption of the sensory", "synonym_substitution": "filarial - infected patients. These data provide hint to the nerve pathway induced by infection and those systemic alterations understand in chronic helminth infection. A longstanding issue in environmental health is the indigence to sympathize the role the environment plays in human brain development. The brain of the neonate is peculiarly susceptible to disruption of the sensory", "butter_fingers": " fiparial-infected patients. Uhese data providg xlues vo the lathways induced by infection and thlsw sysuvmic alterations seen in chronpc helminrh iifection. A longsvznding lfsue ln enriconmental healtm is the nead to understatd tke role the environment plays in humwn braim fevelopment. Thg brapn of fhe neonate is particularly suscepfible tm disruption pf the sensory", "random_deletion": "filarial-infected patients. These data provide clues to induced infection and systemic alterations seen longstanding in environmental health the need to the role the environment plays in brain development. The brain of the neonate is particularly susceptible to disruption of sensory", "change_char_case": " filarial-infected patients. THese data prOvide CluEs tO tHe paThwaYs induced by infECtioN and those systemic alterAtionS sEEn in CHrOnic hElminth INfECTioN. A LoNgsTaNDiNg issUe iN enviroNmental heaLth Is The need to undERsTand the rolE thE environment PlaYs in huMaN brAIn devEloPment. the braIN of the Neonate is PaRTiculaRLy suscePTIbLe to Disruption of the seNSoRY", "whitespace_perturbation": " filarial-infected patient s. These d ata p rov ide  c lues  tothe pathways i n duce d by infection and tho se sy st e mica lt erati ons see n  i n chr on ic  he lm i nt h inf ect ion. Alongstandi ngis sue in envir o nm ental heal this the needtounders ta ndt he ro lethe e nviron m ent pl ays in hu ma n  brain develop m e nt . Th e brain of the ne o na t e is particula rly su sc e pt i b letodisruption  o f the sensory ", "underscore_trick": " filarial-infected_patients. These_data provide clues to_the pathways_induced_by infection_and_those systemic alterations_seen in chronic_helminth infection. A longstanding_issue in environmental_health_is the need to understand the role the environment plays in human brain development._The_brain of_the_neonate_is particularly susceptible to disruption_of the sensory"}
{"text": " found that broad neural expression rescued the anesthesia phenotypes but none of 20 drivers that produced restricted expression gave reliable rescue (promising results with the tim-GAL4 driver using the postural assay now appear to be due to a non-specific sensitization to stressors). Happily, a new survey of restricted GAL4 lines", "synonym_substitution": "found that broad neural expression rescue the anesthesia phenotype but none of 20 drivers that produced restricted formula yield reliable rescue (promising resultant role with the tim - GAL4 driver use the postural assay now look to be ascribable to a non - specific sensitization to stressors). Happily, a modern survey of restricted GAL4 lines", "butter_fingers": " foknd that broad neural exkression rescued jhw anesvhesia lhenotypds but none of 20 drivers that peoductb restricted expresskon gave geliable eescne (promising resnmts witm the bim-GAN4 driver using jhe postural assay now appaaf co be due to a non-specific sensitizaeion to shressors). Happijy, a gew alryey of restricted GAL4 lines", "random_deletion": "found that broad neural expression rescued the but of 20 that produced restricted results the tim-GAL4 driver the postural assay appear to be due to a sensitization to stressors). Happily, a new survey of restricted GAL4 lines", "change_char_case": " found that broad neural expreSsion rescuEd the AneSthEsIa phEnotYpes but none of 20 dRIverS that produced restricteD exprEsSIon gAVe ReliaBle rescUE (pROMisInG rEsuLtS WiTh the Tim-gAL4 drivEr using the PosTuRal assay now aPPeAr to be due tO a nOn-specific seNsiTizatiOn To sTRessoRs). HAppilY, a new sURvey of RestricteD Gal4 lines", "whitespace_perturbation": " found that broad neural e xpressionrescu edthe  a nest hesi a phenotypes b u t no ne of 20 drivers thatprodu ce d  res t ri ctedexpress i on g ave  r el iab le re scue(pr omising  results w ith  t he tim-GAL4d ri ver usingthe  postural as say  now a pp ear to be  du e toa non- s pecifi c sensiti za t ion to stresso r s ).  Hap pily, a new surve y  o f  restricted GA L4 lin es ", "underscore_trick": " found_that broad_neural expression rescued the_anesthesia phenotypes_but_none of_20_drivers that produced_restricted expression gave_reliable rescue (promising results_with the tim-GAL4_driver_using the postural assay now appear to be due to a non-specific sensitization to_stressors)._Happily, a_new_survey_of restricted GAL4 lines"}
{"text": " was the case in our preliminary study of 14 IGD-related genes, this would provide further evidence that heterozygous variants in these genes may confer an increased susceptibility to developing HA in the setting of physiologic stressors, such as nutritional deficiency, extreme exercise, or psychological stress. At the other extreme of pubertal development are", "synonym_substitution": "was the case in our preliminary study of 14 IGD - related genes, this would leave further evidence that heterozygous random variable in these genes may confer an increased susceptibility to developing hour angle in the setting of physiologic stressors, such as nutritional deficiency, extreme use, or psychological tension. At the other extreme of pubertal development are", "butter_fingers": " wad the case in our prelimlnary study of 14 NTD-relaved genss, this dould provide further evidenre tyat htnerozygous variants iv these gvnes may xonftr an increased snaceptibljity bo dereooping HA in tme setting mf physiologic sgrzssors, such as nutritional deficiencr, extreke exercise, or pfychpjogidal stress. At the other extreme of pubertel development sre", "random_deletion": "was the case in our preliminary study IGD-related this would further evidence that may an increased susceptibility developing HA in setting of physiologic stressors, such as deficiency, extreme exercise, or psychological stress. At the other extreme of pubertal development", "change_char_case": " was the case in our preliminarY study of 14 IGd-relaTed GenEs, This WoulD provide furtheR EvidEnce that heterozygous vaRiantS iN ThesE GeNes maY confer AN iNCReaSeD sUscEpTIbIlity To dEvelopiNg HA in the sEttInG of physiologIC sTressors, suCh aS nutritional DefIciencY, eXtrEMe exeRciSe, or pSycholOGical sTress. At thE oTHer extREme of puBERtAl deVelopment are", "whitespace_perturbation": " was the case in our preli minary stu dy of  14  IG D- rela tedgenes, this wo u ld p rovide further evidenc e tha th eter o zy gousvariant s  i n the se  g ene sm ay  conf eran incr eased susc ept ib ility to dev e lo ping HA in  th e setting of  ph ysiolo gi c s t resso rs,  such  as nu t rition al defici en c y, ext r eme exe r c is e, o r psychological s t re s s. At the othe r extr em e  o f pub ert al develop me nt ar e ", "underscore_trick": " was_the case_in our preliminary study_of 14_IGD-related_genes, this_would_provide further evidence_that heterozygous variants_in these genes may_confer an increased_susceptibility_to developing HA in the setting of physiologic stressors, such as nutritional deficiency, extreme_exercise,_or psychological_stress._At_the other extreme of pubertal_development are"}
{"text": "DE level during pregnancy in relation to adjusted odds of cryptorchidism, hypospadias, and polythelia [extra nipples] among their male offspring. We evaluated prenatal PCB exposure in relation to cognitive test scores (IQ) on the Wechsler Intelligence Scale for Children (WISC) at age", "synonym_substitution": "DE level during pregnancy in relation to adjusted odds of cryptorchidism, hypospadias, and polythelia [ excess nipple ] among their male offspring. We evaluated prenatal PCB vulnerability in relative to cognitive test scores (IQ) on the Wechsler Intelligence Scale for Children (WISC) at historic period", "butter_fingers": "DE pevel during pregnancy ik relation to adlysted mdds or cryptofchidism, hypospadias, and polbtheoia [eztra nipples] among thekr male ovfspring. We tvaluated prenatal PCB exijsurs in xeoation to cognltive test vcores (IQ) on tve Wzchsler Intelligence Scale for Childwen (WISV) wt age", "random_deletion": "DE level during pregnancy in relation to of hypospadias, and [extra nipples] among prenatal exposure in relation cognitive test scores on the Wechsler Intelligence Scale for (WISC) at age", "change_char_case": "DE level during pregnancy in rElation to aDjustEd oDds Of CrypTorcHidism, hypospadIAs, anD polythelia [extra nippleS] amonG tHEir mALe OffspRing. We eVAlUATed PrEnAtaL Pcb eXposuRe iN relatiOn to cognitIve TeSt scores (IQ) on THe wechsler InTelLigence Scale For childrEn (wISc) At age", "whitespace_perturbation": "DE level during pregnancyin relatio n toadj ust ed  odd s of  cryptorchidis m , hy pospadias, and polythe lia [ ex t ra n i pp les]among t h ei r mal eof fsp ri n g.  We e val uated p renatal PC B e xp osure in rel a ti on to cogn iti ve test scor es(IQ) o nthe Wechs ler  Inte lligen c e Scal e for Chi ld r en (WI S C) at a g e ", "underscore_trick": "DE level_during pregnancy_in relation to adjusted_odds of_cryptorchidism,_hypospadias, and_polythelia_[extra nipples] among_their male offspring._We evaluated prenatal PCB_exposure in relation_to_cognitive test scores (IQ) on the Wechsler Intelligence Scale for Children (WISC) at age"}
{"text": " electroporation resulted in enhanced cellular viability compared to post-electroporation transduction. Flow cytometry revealed efficient rAAV transduction at 4 days post-transduction (range 18-46% copGFP+ cells). The percentage of cells expressing copGFP slowly decreased over the extended culture period, stabilizing at approximately 5-10", "synonym_substitution": "electroporation resulted in enhanced cellular viability compared to post - electroporation transduction. Flow cytometry reveal effective rAAV transduction at 4 days post - transduction (compass 18 - 46% copGFP+ cell). The percentage of cells express copGFP lento decreased over the extended culture period, stabilizing at approximately 5 - 10", "butter_fingers": " elfctroporation resulted ik enhanced cellular viauility dompared to post-electroporation tranddyctiob. Flow cytometry reveaued efficpent rAAV traisduction at 4 daba post-tvcnsdudbion (xaige 18-46% copGFP+ celks). The perwentage of celns erpressing copGFP slowly decreased ovqr the rxhended culture perpoq, stzbilizing at approximately 5-10", "random_deletion": "electroporation resulted in enhanced cellular viability compared transduction. cytometry revealed rAAV transduction at copGFP+ The percentage of expressing copGFP slowly over the extended culture period, stabilizing approximately 5-10", "change_char_case": " electroporation resulted in Enhanced ceLlulaR viAbiLiTy coMparEd to post-electrOPoraTion transduction. Flow cyTometRy REveaLEd EfficIent rAAv TrANSduCtIoN at 4 DaYS pOst-trAnsDuction (Range 18-46% copGFp+ ceLlS). The percentaGE oF cells exprEssIng copGFP sloWly DecreaSeD ovER the eXteNded cUlture PEriod, sTabilizinG aT ApproxIMately 5-10", "whitespace_perturbation": " electroporation resultedin enhance d cel lul arvi abil itycompared to po s t-el ectroporation transduc tion.  F l ow c y to metry  reveal e de f fic ie nt  rA AV tr ansdu cti on at 4  days post -tr an sduction (ra n ge  18-46% co pGF P+ cells). T hepercen ta geo f cel lsexpre ssingc opGFPslowly de cr e ased o v er thee x te nded  culture period,s ta b ilizing at app roxima te l y5 - 10", "underscore_trick": " electroporation_resulted in_enhanced cellular viability compared_to post-electroporation_transduction._Flow cytometry_revealed_efficient rAAV transduction_at 4 days_post-transduction (range 18-46% copGFP+_cells). The percentage_of_cells expressing copGFP slowly decreased over the extended culture period, stabilizing at approximately 5-10"}
{"text": " mice were viable, fertile and indistinguishable from wild type littermates. Examination of beta-galactosidase expression as a surrogate for EpCAM revealed that EpCAM was expressed in a variety of developing epitehelial structures in skin and other organs. Mating of EpCAM +/- male and female mice gave rise to only wild type", "synonym_substitution": "mice were viable, fertile and indistinguishable from raving mad character littermates. Examination of beta - galactosidase expression as a deputy for EpCAM revealed that EpCAM was express in a variety of develop epitehelial structures in skin and early organ. Mating of EpCAM + /- male and female mouse gave rise to entirely crazy type", "butter_fingers": " mife were viable, fertile akd indistinguishcvle frmm wils type lkttermates. Examination of beva-gaoactowidase expression as a surrogatv for EpCQM rtvealed that EpCAM was exixesses in c tariety of devekoping epidehelial strucdufed in skin and other organs. Mating os EpCAM +/- lale and femalg mict gwve dpst to only wild type", "random_deletion": "mice were viable, fertile and indistinguishable from littermates. of beta-galactosidase as a surrogate was in a variety developing epitehelial structures skin and other organs. Mating of +/- male and female mice gave rise to only wild type", "change_char_case": " mice were viable, fertile and iNdistinguiShablE frOm wIlD typE litTermates. ExaminATion Of beta-galactosidase expRessiOn AS a suRRoGate fOr EpCAM REvEALed ThAt epCaM WAs ExpreSseD in a varIety of deveLopInG epitehelial STrUctures in sKin And other orgaNs. MAting oF EPCAm +/- Male aNd fEmale Mice gaVE rise tO only wild TyPE", "whitespace_perturbation": " mice were viable, fertile  and indis tingu ish abl efrom  wil d type litterm a tes.  Examination of beta-g alact os i dase ex press ion asa  s u r rog at efor  E p CA M rev eal ed that  EpCAM was  ex pr essed in a v a ri ety of dev elo ping epitehe lia l stru ct ure s  in s kin  andothero rgans.  Mating o fE pCAM + / - malea n dfema le mice gave rise to only wild type ", "underscore_trick": " mice_were viable,_fertile and indistinguishable from_wild type_littermates._Examination of_beta-galactosidase_expression as a_surrogate for EpCAM_revealed that EpCAM was_expressed in a_variety_of developing epitehelial structures in skin and other organs. Mating of EpCAM +/- male_and_female mice_gave_rise_to only wild type"}
{"text": " its suppression by anesthetics, we previously screened for changes in sensitivity to halothane in lines that were missing one copy of a large block of DNA. Are the hits we found genetically complex or simple? We had previously shown that the effect of the 75 kb ED1 deletion could be reversed by adding back a 15 kb", "synonym_substitution": "its suppression by anesthetics, we previously screened for changes in sensitivity to halothane in occupation that were miss one copy of a big engine block of DNA. Are the hits we found genetically complex or dim-witted? We had previously show that the effect of the 75 kb ED1 omission could be overrule by adding back a 15 kilobyte", "butter_fingers": " itd suppression by anestheuics, we previousli wcreenxd for dhanges kn sensitivity to halothane mn lunes ukat were missing one copy of w large vlocj of DNA. Arx the hibf we nound jenetically comklex or simpne? We had prevhojspy shown that the effect of the 75 kb ED1 delrtlon could be rgverstd fy asding back a 15 kb", "random_deletion": "its suppression by anesthetics, we previously screened in to halothane lines that were large of DNA. Are hits we found complex or simple? We had previously that the effect of the 75 kb ED1 deletion could be reversed by back a 15 kb", "change_char_case": " its suppression by anesthetiCs, we previoUsly sCreEneD fOr chAngeS in sensitivity TO halOthane in lines that were mIssinG oNE copY Of A largE block oF dNa. aRe tHe HiTs wE fOUnD geneTicAlly comPlex or simpLe? WE hAd previously SHoWn that the eFfeCt of the 75 kb ED1 dEleTion coUlD be REversEd bY addiNg back A 15 Kb", "whitespace_perturbation": " its suppression by anesth etics, weprevi ous lysc reen ed f or changes ins ensi tivity to halothane in  line st hatw er e mis sing on e  c o p y o falar ge bl ock o f D NA. Are  the hitswefo und genetica l ly  complex o r s imple? We ha d p reviou sl y s h own t hat  theeffect of the  75 kb ED 1d eletio n  couldb e  r ever sed by adding bac k  a 15 kb", "underscore_trick": " its_suppression by_anesthetics, we previously screened_for changes_in_sensitivity to_halothane_in lines that_were missing one_copy of a large_block of DNA._Are_the hits we found genetically complex or simple? We had previously shown that the_effect_of the_75_kb_ED1 deletion could be reversed_by adding back a 15_kb"}
{"text": "-flanked reporter cassette and the endogenous ITGB2 target gene are concomitantly cleaved by Cas9, thus promoting NHEJ-mediated transgene insertion at the site of the Cas9-induced chromosomal double-strand break. To determine the optimal time of rAAV transduction, HSPCs were transduced with rAA", "synonym_substitution": "-flanked reporter cassette and the endogenous ITGB2 target gene are concomitantly cleaved by Cas9, thus promoting NHEJ - intercede transgene interpolation at the site of the Cas9 - induced chromosomal bivalent - strand open frame. To determine the optimal clock time of rAAV transduction, HSPCs were transduced with rAA", "butter_fingers": "-flajked reporter cassette akd the endogenous ITGB2 varget fene are concomitantly cleaved by Cad9, rhus kgomoting NHEJ-mediated transgenv insertiin au the site of the Cas9-indugzd chdlmosmnal double-strakd break. To determine the ootnmal time of rAAV transduction, HSPCs were ttajsduced with rWA", "random_deletion": "-flanked reporter cassette and the endogenous ITGB2 are cleaved by thus promoting NHEJ-mediated of Cas9-induced chromosomal double-strand To determine the time of rAAV transduction, HSPCs were with rAA", "change_char_case": "-flanked reporter cassette anD the endogeNous ItGB2 TarGeT genE are Concomitantly cLEaveD by Cas9, thus promoting NHEj-mediAtED traNSgEne inSertion AT tHE SitE oF tHe CAs9-INdUced cHroMosomal Double-straNd bReAk. To determinE ThE optimal tiMe oF rAAV transduCtiOn, HSPCS wEre TRansdUceD with RAA", "whitespace_perturbation": "-flanked reporter cassette  and the e ndoge nou s I TG B2 t arge t gene are con c omit antly cleaved by Cas9,  thus  p r omot i ng  NHEJ -mediat e dt r ans ge ne  in se r ti on at  th e siteof the Cas 9-i nd uced chromos o ma l double-s tra nd break. To  de termin ethe optim altimeof rAA V  trans duction,HS P Cs wer e  transd u c ed  wit h rAA", "underscore_trick": "-flanked reporter_cassette and_the endogenous ITGB2 target_gene are_concomitantly_cleaved by_Cas9,_thus promoting NHEJ-mediated_transgene insertion at_the site of the_Cas9-induced chromosomal double-strand_break._To determine the optimal time of rAAV transduction, HSPCs were transduced with rAA"}
{"text": " and human HCC (n=139). The Jun-signature successfully discriminated human HCC into clusters displaying either WT or Jun-KO signatures. Notably, integration of the Jun signature with the human data revealed a clear and significant association of Jun-KO and Jun-WT signatures, respectively, with either Hepatocyte (HC)", "synonym_substitution": "and human HCC (n=139). The Jun - signature successfully discriminated human HCC into clusters displaying either WT or Jun - KO signature. Notably, consolidation of the Jun signature with the human data reveal a well-defined and significant association of Jun - KO and Jun - WT key signature, respectively, with either Hepatocyte (HC )", "butter_fingers": " anf human HCC (n=139). The Jun-sigkature successfully disrriminafed humav HCC into clusters displayiig euther WT or Jun-KO signaturer. Notably, integrarion if the Jun signatuvz witg the iuman data revesled a cledr and signifiwavt association of Jun-KO and Jun-WT siggatures, rfspectively, wijh eiuhew Helatocyte (HC)", "random_deletion": "and human HCC (n=139). The Jun-signature successfully HCC clusters displaying WT or Jun-KO Jun with the human revealed a clear significant association of Jun-KO and Jun-WT respectively, with either Hepatocyte (HC)", "change_char_case": " and human HCC (n=139). The Jun-signatuRe successfUlly dIscRimInAted HumaN HCC into clusteRS disPlaying either WT or Jun-KO SignaTuREs. NoTAbLy, intEgratioN Of THE JuN sIgNatUrE WiTh the HumAn data rEvealed a clEar AnD significant ASsOciation of jun-kO and Jun-WT siGnaTures, rEsPecTIvely, WitH eithEr HepaTOcyte (Hc)", "whitespace_perturbation": " and human HCC (n=139). Th e Jun-sign ature  su cce ss full y di scriminated hu m an H CC into clusters displ aying  e i ther WT  or J un-KO s i gn a t ure s.  N ota bl y ,integ rat ion ofthe Jun si gna tu re with theh um an data re vea led a clearand  signi fi can t  asso cia tionof Jun - KO and  Jun-WT s ig n atures ,  respec t i ve ly,with either Hepat o cy t e (HC)", "underscore_trick": " and_human HCC_(n=139). The Jun-signature successfully_discriminated human_HCC_into clusters_displaying_either WT or_Jun-KO signatures. Notably,_integration of the Jun_signature with the_human_data revealed a clear and significant association of Jun-KO and Jun-WT signatures, respectively, with_either_Hepatocyte (HC)"}
{"text": " For ED4065, our mutant analysis implicates the orc4 gene as the locus of haploinsufficiency. This gene is well known as a key component of the Origin Recognition Complex, a multi-protein ensemble first identified for its role in loading replication origins with key proteins. However, in both flies", "synonym_substitution": "For ED4065, our mutant analysis implicates the orc4 gene as the locus of haploinsufficiency. This gene is well known as a cardinal part of the Origin Recognition Complex, a multi - protein corps de ballet first identified for its role in load replication origins with cardinal proteins. However, in both flies", "butter_fingers": " Fog ED4065, our mutant analysis implicates the orc4 geie as tge locus of haploinsufficiency. This jene is wtjl known as a key zomponent of the Irigmn Recognition Complex, a multi-lvoteiu xnsemble first ldentified xor its role it uocding replication origins with key pwoteins. Hlwever, in both flits", "random_deletion": "For ED4065, our mutant analysis implicates the as locus of This gene is component the Origin Recognition a multi-protein ensemble identified for its role in loading origins with key proteins. However, in both flies", "change_char_case": " For ED4065, our mutant analysis impLicates the Orc4 geNe aS thE lOcus Of haPloinsufficienCY. ThiS gene is well known as a key CompoNeNT of tHE ORigin recogniTIoN cOmpLeX, a MulTi-PRoTein eNseMble firSt identifiEd fOr Its role in loaDInG replicatiOn oRigins with keY prOteins. hoWevER, in boTh fLies", "whitespace_perturbation": " For ED4065, our mutant an alysis imp licat esthe  o rc4gene  as the locuso f ha ploinsufficiency. This  gene  i s  wel l  k nownas a ke y  c o m pon en tofth e  O rigin  Re cogniti on Complex , a  m ulti-protein en semble fir stidentified f orits ro le  in loadi ngrepli cation origin s with ke yp rotein s . Howev e r ,in b oth flies", "underscore_trick": " For_ED4065, our_mutant analysis implicates the_orc4 gene_as_the locus_of_haploinsufficiency. This gene_is well known_as a key component_of the Origin_Recognition_Complex, a multi-protein ensemble first identified for its role in loading replication origins with_key_proteins. However,_in_both_flies"}
{"text": " for natural killer cells (Raet1a-e) and simultaneous repression of MHC-I. We confirmed these results using FACS analysis of hepatocytes isolated from 3-m-old dysplastic livers. However, the most dramatic changes of gene expression were found in tumors. The functional categories of differentially expressed genes involved translation", "synonym_substitution": "for natural killer cells (Raet1a - e) and coincident repression of MHC - I. We confirm these results using FACS psychoanalysis of hepatocytes isolated from 3 - thousand - old dysplastic livers. However, the about dramatic changes of gene expression were found in tumor. The running categories of differentially expressed gene involved translation", "butter_fingers": " fog natural killer cells (Rxet1a-e) and simuljabeous cepressjon of MFC-I. We confirmed these resulvs uwing DACS analysis of hepatucytes isllated feom 3-n-ild dysplastic livcxs. Hoscver, chx most dramatic changes ox gene expresshov cere found in tumors. The functional sategoroed of differentyallj qxprsssed genes involved translation", "random_deletion": "for natural killer cells (Raet1a-e) and simultaneous MHC-I. confirmed these using FACS analysis dysplastic However, the most changes of gene were found in tumors. The functional of differentially expressed genes involved translation", "change_char_case": " for natural killer cells (Raet1A-e) and simulTaneoUs rEprEsSion Of MHc-I. We confirmed tHEse rEsults using FACS analysiS of hePaTOcytES iSolatEd from 3-m-OLd DYSplAsTiC liVeRS. HOweveR, thE most drAmatic chanGes Of Gene expressiON wEre found in TumOrs. The functiOnaL categOrIes OF diffEreNtialLy exprESsed geNes involvEd TRanslaTIon", "whitespace_perturbation": " for natural killer cells(Raet1a-e)  andsim ult an eous  rep ression of MHC - I. W e confirmed these resu lts u si n g FA C Sanaly sis ofh ep a t ocy te siso la t ed  from  3- m-old d ysplasticliv er s. However,t he  most dram ati c changes of  ge ne exp re ssi o n wer e f oundin tum o rs. Th e functio na l  categ o ries of d if fere ntially expressed ge n es involved tr anslat io n ", "underscore_trick": " for_natural killer_cells (Raet1a-e) and simultaneous_repression of_MHC-I._We confirmed_these_results using FACS_analysis of hepatocytes_isolated from 3-m-old dysplastic_livers. However, the_most_dramatic changes of gene expression were found in tumors. The functional categories of differentially_expressed_genes involved_translation"}
{"text": "avita Singh (RTB) on a major surface antigen of infected red cells, viz., VAR2CSA. This protein is a member of the large PfEMP1 family and has been implicated in pregnancy associated malaria through binding to chondroitin sulfate A (CSA) in the placenta. Dr. Singh", "synonym_substitution": "avita Singh (RTB) on a major surface antigen of infected red cells, viz. , VAR2CSA. This protein is a extremity of the big PfEMP1 family and has been implicated in pregnancy associated malaria through bind to chondroitin sulfate A (CSA) in the placenta. Dr. Singh", "butter_fingers": "aviha Singh (RTB) on a major rurface antigen of infxcted rsd cells, viz., VAR2CSA. This protein is e menber if the large PfEMP1 famkly and hws been umplmcated in pregnaidy assognated lalaxie through bindikg to chondsoitin sulfate A (CDA) in the placenta. Dr. Singh", "random_deletion": "avita Singh (RTB) on a major surface infected cells, viz., This protein is PfEMP1 and has been in pregnancy associated through binding to chondroitin sulfate A in the placenta. Dr. Singh", "change_char_case": "avita Singh (RTB) on a major surfAce antigen Of infEctEd rEd CellS, viz., vAR2CSA. This protEIn is A member of the large PfEMP1 FamilY aND has BEeN implIcated iN PrEGNanCy AsSocIaTEd MalarIa tHrough bInding to chOndRoItin sulfate A (csA) In the placeNta. dr. Singh", "whitespace_perturbation": "avita Singh (RTB) on a maj or surface  anti gen  of  i nfec tedred cells, viz . , VA R2CSA. This protein is  a me mb e r of th e lar ge PfEM P 1f a mil yan d h as be en im pli cated i n pregnanc y a ss ociated mala r ia  through b ind ing to chond roi tin su lf ate A (CS A)in th e plac e nta. D r. Singh", "underscore_trick": "avita Singh_(RTB) on_a major surface antigen_of infected_red_cells, viz.,_VAR2CSA._This protein is_a member of_the large PfEMP1 family_and has been_implicated_in pregnancy associated malaria through binding to chondroitin sulfate A (CSA) in the placenta._Dr._Singh"}
{"text": " the interaction of naive T cells with foreign antigen ligands in the form of oligomers of foreign peptide-MHC class II molecule complexes (pMHC tetramers), we have made the remarkable finding that the affinity of TCRs for self-ligand as determined in the thymus during positive selection directly correlates with the", "synonym_substitution": "the interaction of naive T cells with foreign antigen ligand in the human body of oligomers of foreign peptide - MHC class II atom complexes (pMHC tetramers), we have make the remarkable finding that the affinity of TCRs for self - ligand equally specify in the thymus during convinced selection directly correlate with the", "butter_fingers": " thf interaction of naive T cells with forgitn antmgen lifands in the form of oligomers of foceigb pepupde-MHC class II molecjle complvxes (pMHC tetcamers), we have mese the vzmarkznle fnnving that the anfinity of DCRs for self-lhgxnb as determined in the thymus during positife selection dirgctly sorrslates with the", "random_deletion": "the interaction of naive T cells with ligands the form oligomers of foreign (pMHC we have made remarkable finding that affinity of TCRs for self-ligand as in the thymus during positive selection directly correlates with the", "change_char_case": " the interaction of naive T celLs with foreIgn anTigEn lIgAnds In thE form of oligomeRS of fOreign peptide-MHC class Ii moleCuLE comPLeXes (pMhC tetraMErS), WE haVe MaDe tHe REmArkabLe fInding tHat the affiNitY oF TCRs for self-LIgAnd as deterMinEd in the thymuS duRing poSiTivE SelecTioN direCtly coRRelateS with the", "whitespace_perturbation": " the interaction of naiveT cells wi th fo rei gnan tige n li gands in the f o rm o f oligomers of foreign  pept id e -MHC cl ass I I molec u le c omp le xe s ( pM H Ctetra mer s), wehave madethe  r emarkable fi n di ng that th e a ffinity of T CRs  for s el f-l i gandasdeter minedi n thethymus du ri n g posi t ive sel e c ti on d irectly correlate s  w i th the", "underscore_trick": " the_interaction of_naive T cells with_foreign antigen_ligands_in the_form_of oligomers of_foreign peptide-MHC class_II molecule complexes (pMHC_tetramers), we have_made_the remarkable finding that the affinity of TCRs for self-ligand as determined in the_thymus_during positive_selection_directly_correlates with the"}
{"text": "2 may play an important role in social behavior; recent work in other laboratories support this view. To gain further insight into the molecular profile of CA2 neurons, we used RNAseq to measure mRNA from specific cellular compartments of tissue isolated by LCM. These studies have revealed that CA2 neurons express an unusually large number of", "synonym_substitution": "2 may play an important role in social behavior; late workplace in other laboratories confirm this opinion. To gain further insight into the molecular visibility of CA2 neurons, we used RNAseq to measure mRNA from specific cellular compartment of tissue isolated by LCM. These studies have reveal that CA2 neurons express an unusually big number of", "butter_fingers": "2 maj play an important role in social beharuor; rerent wodk in otfer laboratories support thid ciew. Uj gain further inskght into the molwculer profile of CA2 neurons, we ussf RNCsxq to measure mTNA from spewific cellular cum'artments of tissue isolated by LCM. Ehese syufies have revewled ehat BA2 neurons express an unusually large iumber of", "random_deletion": "2 may play an important role in recent in other support this view. the profile of CA2 we used RNAseq measure mRNA from specific cellular compartments tissue isolated by LCM. These studies have revealed that CA2 neurons express an large number of", "change_char_case": "2 may play an important role in sOcial behavIor; reCenT woRk In otHer lAboratories supPOrt tHis view. To gain further inSight InTO the MOlEculaR profilE Of ca2 NeuRoNs, We uSeD rNaseq tO meAsure mRnA from specIfiC cEllular compaRTmEnts of tissUe iSolated by LCM. theSe studIeS haVE reveAleD that cA2 neurONs exprEss an unusUaLLy largE Number oF", "whitespace_perturbation": "2 may play an important ro le in soci al be hav ior ;rece nt w ork in other l a bora tories support this vi ew. T og ainf ur therinsight in t o  th emo lec ul a rprofi leof CA2neurons, w e u se d RNAseq tom ea sure mRNAfro m specific c ell ular c om par t ments  of  tiss ue iso l ated b y LCM. Th es e  studi e s haver e ve aled  that CA2 neurons ex p ress an unusua lly la rg e  n u m ber  of ", "underscore_trick": "2 may_play an_important role in social_behavior; recent_work_in other_laboratories_support this view._To gain further_insight into the molecular_profile of CA2_neurons,_we used RNAseq to measure mRNA from specific cellular compartments of tissue isolated by_LCM._These studies_have_revealed_that CA2 neurons express an_unusually large number of"}
{"text": " or marine mammals. To facilitate interpretation of experimental data on polychlorinated biphenyl (PCB) toxicity, we determined whether the PCB doses used in animal experiments result in tissue levels that were comparable to those observed in background-exposed humans. We identified 8 animal studies in which PCB tissue levels had been measured after oral", "synonym_substitution": "or marine mammals. To facilitate interpretation of experimental datum on polychlorinated biphenyl (PCB) perniciousness, we determine whether the PCB doses use in animal experiment result in tissue levels that were comparable to those respect in background - exposed world. We identified 8 animal studies in which PCB tissue level had been measured after oral", "butter_fingers": " or marine mammals. To facilltate interpretajiin of xxperimsntal daga on polychlorinated biphenbl (PXB) tozicity, we determined wfether thv PCB dosws uwwd in animem experlienta resblv in tissue levgls that wera comparable tm ghlse observed in background-exposed htmans. Wr ldentified 8 anymal ftudjvs in which PCB tissue levels hzd been measured aftrr oral", "random_deletion": "or marine mammals. To facilitate interpretation of on biphenyl (PCB) we determined whether animal result in tissue that were comparable those observed in background-exposed humans. We 8 animal studies in which PCB tissue levels had been measured after oral", "change_char_case": " or marine mammals. To facilitaTe interpreTatioN of ExpErImenTal dAta on polychlorINateD biphenyl (PCB) toxicity, we DeterMiNEd whEThEr the pCB doseS UsED In aNiMaL exPeRImEnts rEsuLt in tisSue levels tHat WeRe comparable TO tHose observEd iN background-eXpoSed humAnS. We IDentiFieD 8 animAl studIEs in whIch PCB tisSuE Levels HAd been mEASuRed aFter oral", "whitespace_perturbation": " or marine mammals. To fac ilitate in terpr eta tio nof e xper imental data o n  pol ychlorinated biphenyl(PCB)  t o xici t y,  we d etermin e dw h eth er  t hePC B  d osesuse d in an imal exper ime nt s result int is sue levels  th at were comp ara ble to  t hos e  obse rve d inbackgr o und-ex posed hum an s . We i d entifie d 8anim al studies in whi c hP CB tissue leve ls had  b e en m eas ure d after or al ", "underscore_trick": " or_marine mammals._To facilitate interpretation of_experimental data_on_polychlorinated biphenyl_(PCB)_toxicity, we determined_whether the PCB_doses used in animal_experiments result in_tissue_levels that were comparable to those observed in background-exposed humans. We identified 8 animal_studies_in which_PCB_tissue_levels had been measured after_oral"}
{"text": " is to understand how cellular process work at the molecular scale. To accomplish this, current tools were inadequate. Thus, we focused on the development and application of new imaging methods to uncover the structure of molecules and organelles inside cells. In my group we continue to pioneer four novel imaging technologies. These include, 1) high", "synonym_substitution": "is to understand how cellular process work at the molecular scale. To carry through this, current creature were inadequate. Thus, we focused on the development and lotion of new imaging methods to uncover the social organization of atom and organelles inside cell. In my group we continue to pioneer four fresh imaging technologies. These include, 1) high", "butter_fingers": " is to understand how celluuar process work at thx molechlar scaue. To accomplish this, currenv toils wtge inadequate. Thus, we focused ln the dwvelipment and elplicatljn or new mmaging methods to uncoves the structura uf molecules and organelles inside cejls. In ky group we contynue eo pjoneer four novel imaging technolofies. Thtse include, 1) high", "random_deletion": "is to understand how cellular process work molecular To accomplish current tools were the and application of imaging methods to the structure of molecules and organelles cells. In my group we continue to pioneer four novel imaging technologies. These 1) high", "change_char_case": " is to understand how cellular Process worK at thE moLecUlAr scAle. TO accomplish thiS, CurrEnt tools were inadequate. thus, wE fOCuseD On The deVelopmeNT aND AppLiCaTioN oF NeW imagIng Methods To uncover tHe sTrUcture of moleCUlEs and organEllEs inside cellS. In My grouP wE coNTinue To pIoneeR four nOVel imaGing technOlOGies. ThESe incluDE, 1) HiGh", "whitespace_perturbation": " is to understand how cell ular proce ss wo rkatth e mo lecu lar scale. Toa ccom plish this, current to ols w er e  ina d eq uate.  Thus,w ef o cus ed  o n t he de velop men t and a pplication  of  n ew imaging m e th ods to unc ove r the struct ure  of mo le cul e s and  or ganel les in s ide ce lls. In m yg roup w e  contin u e  t o pi oneer four noveli ma g ing technologi es. Th es e  i n c lud e,1) high", "underscore_trick": " is_to understand_how cellular process work_at the_molecular_scale. To_accomplish_this, current tools_were inadequate. Thus,_we focused on the_development and application_of_new imaging methods to uncover the structure of molecules and organelles inside cells. In_my_group we_continue_to_pioneer four novel imaging technologies._These include, 1) high"}
{"text": " associated with the steepest declines in BMIz (p <.001) and fat mass (p <=.03). Thus, in obesity-prone adolescent girls, IPT was associated with improvements in BMIz over 3 years among youth with high social-adjustment problems or trait anxiety. Future studies are planned to", "synonym_substitution": "associated with the steepest declines in BMIz (p < .001) and fat mass (phosphorus < = .03). therefore, in fleshiness - prone adolescent girls, IPT was associated with improvements in BMIz over 3 long time among youth with high social - alteration problems or trait anxiety. Future studies are plan to", "butter_fingers": " asdociated with the steepert declines in YNIz (p <.001) and fzt mass (o <=.03). Thus, in obesity-prone adolxscebt giels, IPT was associated with impgovements in UMIz over 3 years among youth wjbh hiyh social-adjustmgnt problems or trait anxiath. Yuture studies are planned to", "random_deletion": "associated with the steepest declines in BMIz and mass (p Thus, in obesity-prone with in BMIz over years among youth high social-adjustment problems or trait anxiety. studies are planned to", "change_char_case": " associated with the steepest Declines in bMIz (p <.001) And Fat MaSs (p <=.03). THus, iN obesity-prone aDOlesCent girls, IPT was associaTed wiTh IMproVEmEnts iN BMIz ovER 3 yEARs aMoNg YouTh WItH high SocIal-adjuStment probLemS oR trait anxietY. fuTure studieS arE planned to", "whitespace_perturbation": " associated with the steep est declin es in  BM Iz(p  <.0 01)and fat mass ( p  <=. 03). Thus, in obesity- prone  a d oles c en t gir ls, IPT wa s ass oc ia ted  w i th  impr ove ments i n BMIz ove r 3  y ears among y o ut h with hig h s ocial-adjust men t prob le mso r tra itanxie ty. Fu t ure st udies are  p l annedt o", "underscore_trick": " associated_with the_steepest declines in BMIz_(p <.001)_and_fat mass_(p_<=.03). Thus, in_obesity-prone adolescent girls,_IPT was associated with_improvements in BMIz_over_3 years among youth with high social-adjustment problems or trait anxiety. Future studies are_planned_to"}
{"text": "? end of ORFs. Experiments based on the production of new integration events revealed that the association of Tf1 with LTRs was the result of integration preference. To define the determinants of the target sites we developed an in vivo assay for integration using a plasmid that contained ade6 as the target and a plasmid", "synonym_substitution": "? end of ORFs. Experiments based on the production of newfangled consolidation events revealed that the affiliation of Tf1 with LTRs was the result of consolidation preference. To define the determinant of the target sites we develop an in vivo assay for integration using a plasmid that contain ade6 as the target and a plasmid", "butter_fingers": "? enf of ORFs. Experiments bared on the prodocrion oh new ihtegratiun events revealed that the essoxiatiin of Tf1 with LTRs was the resupt of inregretion preference. To defikz the fetexmmnants of the tsrget sitev we developed av nn vivo assay for integration using w plasmod that containeq adt6 af ths target and a plasmid", "random_deletion": "? end of ORFs. Experiments based on of integration events that the association the of integration preference. define the determinants the target sites we developed an vivo assay for integration using a plasmid that contained ade6 as the target a plasmid", "change_char_case": "? end of ORFs. Experiments based On the produCtion Of nEw iNtEgraTion Events revealed THat tHe association of Tf1 with LtRs waS tHE resULt Of intEgratioN PrEFEreNcE. TO deFiNE tHe detErmInants oF the target SitEs We developed aN In Vivo assay fOr iNtegration usIng A plasmId ThaT ContaIneD ade6 aS the taRGet and A plasmid", "whitespace_perturbation": "? end of ORFs. Experiments  based onthe p rod uct io n of  new  integration e v ents  revealed that the ass ociat io n  ofT f1  with  LTRs w a st h e r es ul t o fi nt egrat ion  prefer ence. To d efi ne  the determi n an ts of thetar get sites we  de velope dani n viv o a ssayfor in t egrati on usingap lasmid that co n t ai nedade6 as the targe t  a n d a plasmid", "underscore_trick": "? end_of ORFs._Experiments based on the_production of_new_integration events_revealed_that the association_of Tf1 with_LTRs was the result_of integration preference._To_define the determinants of the target sites we developed an in vivo assay for_integration_using a_plasmid_that_contained ade6 as the target_and a plasmid"}
{"text": " focused on the role of the Rac guanine nucleotide exchange factor, -PIX, documenting its depletion from FA during myosin-mediated FA maturation and its role in negative regulation of FA maturation to promote rapid FA turnover, lamellipodial protrusion and fast cell migration. A mthods paper describing our method was", "synonym_substitution": "focused on the role of the Rac guanine nucleotide exchange factor, -PIX, documenting its depletion from FA during myosin - intercede FA growth and its role in negative regulation of FA festering to promote rapid FA turnover, lamellipodial bulge and fast cell migration. A mthods paper describe our method was", "butter_fingers": " fofused on the role of the Rac guanine nueoeotidx exchahge factur, -PIX, documenting its deplevion from FA during myosin-mediaged FA manuration qnd mts role in negavjve regmjatikk of YA maturation to promote rdpid FA turnovar, lcmellipodial protrusion and fast celj migrayiln. A mthods paker dtscwibihg our method was", "random_deletion": "focused on the role of the Rac exchange -PIX, documenting depletion from FA its in negative regulation FA maturation to rapid FA turnover, lamellipodial protrusion and cell migration. A mthods paper describing our method was", "change_char_case": " focused on the role of the Rac gUanine nuclEotidE exChaNgE facTor, -PiX, documenting iTS depLetion from FA during myosIn-medIaTEd FA MAtUratiOn and itS RoLE In nEgAtIve ReGUlAtion Of Fa maturaTion to promOte RaPid FA turnoveR, LaMellipodiaL prOtrusion and fAst Cell miGrAtiON. A mthOds Paper DescriBIng our Method was", "whitespace_perturbation": " focused on the role of th e Rac guan ine n ucl eot id e ex chan ge factor, -PI X , do cumenting its depletio n fro mF A du r in g myo sin-med i at e d  FA  m at ura ti o nand i tsrole in  negativereg ul ation of FAm at uration to  pr omote rapidFAturnov er , l a melli pod ial p rotrus i on and  fast cel lm igrati o n. A mt h o ds  pap er describing our me t hod was", "underscore_trick": " focused_on the_role of the Rac_guanine nucleotide_exchange_factor, -PIX,_documenting_its depletion from_FA during myosin-mediated_FA maturation and its_role in negative_regulation_of FA maturation to promote rapid FA turnover, lamellipodial protrusion and fast cell migration._A_mthods paper_describing_our_method was"}
{"text": "-inflammatory function as suggested by others. The results also suggest that EpCAM may be anti-adhesive, rather than pro-adhesive as previously suggested. In studies that are ongoing, we are additionally characterizing the role of EpCAM in Langerhans cell-keratinocyte interactions and in additional immune", "synonym_substitution": "-inflammatory function as suggested by others. The results also indicate that EpCAM may be anti - adhesive, preferably than pro - adhesive as previously suggested. In studies that are ongoing, we are additionally characterizing the character of EpCAM in Langerhans cell - keratinocyte interactions and in extra immune", "butter_fingers": "-infpammatory function as sungested by others. The rxsults zlso sugeest that EpCAM may be anti-avhesuve, rqther than pro-adhesive as previlusly sutgesued. In studies thef are okyoing, ae axe additionally gharacterizhng the role ox DpEAM in Langerhans cell-keratinocyte igteractoojs and in addijionak immhne", "random_deletion": "-inflammatory function as suggested by others. The suggest EpCAM may anti-adhesive, rather than studies are ongoing, we additionally characterizing the of EpCAM in Langerhans cell-keratinocyte interactions in additional immune", "change_char_case": "-inflammatory function as sugGested by otHers. THe rEsuLtS alsO sugGest that EpCAM mAY be aNti-adhesive, rather than pRo-adhEsIVe as PReViousLy suggeSTeD. iN stUdIeS thAt ARe OngoiNg, wE are addItionally cHarAcTerizing the rOLe Of EpCAM in LAngErhans cell-keRatInocytE iNteRActioNs aNd in aDditioNAl immuNe", "whitespace_perturbation": "-inflammatory function assuggestedby ot her s.Th e re sult s also suggest that  EpCAM may be anti-adh esive ,r athe r  t han p ro-adhe s iv e aspr ev iou sl y  s ugges ted . In st udies that  ar eongoing, wea re  additiona lly  characteriz ing  the r ol e o f  EpCA M i n Lan gerhan s  cell- keratinoc yt e  inter a ctionsa n din a dditional immune", "underscore_trick": "-inflammatory function_as suggested_by others. The results_also suggest_that_EpCAM may_be_anti-adhesive, rather than_pro-adhesive as previously_suggested. In studies that_are ongoing, we_are_additionally characterizing the role of EpCAM in Langerhans cell-keratinocyte interactions and in additional immune"}
{"text": " Vpu protein indicating that CBF regulates Vif expression post-transcriptionally. Kinetic studies revealed effects of CBF both on metabolic stability and on the rate of Vif biosynthesis. These effects were dependent on the ability of CBF to interact with Vif pointing to a chaperone function of CBF. Importantly", "synonym_substitution": "Vpu protein indicating that CBF regulates Vif expression post - transcriptionally. energizing cogitation revealed effect of CBF both on metabolic constancy and on the rate of Vif biosynthesis. These effects were dependent on the ability of CBF to interact with Vif bespeak to a chaperone function of CBF. Importantly", "butter_fingers": " Vpk protein indicating thau CBF regulates Vnd exprxssion lost-tranrcriptionally. Kinetic studied eeveaoed effects of CBF botf on metaholic stqbilmty and on the refe of Vly bioannthevms. These effectx were depandent on the dbklnty of CBF to interact with Vif poineing to a chaperone funstiom of DBF. Importantly", "random_deletion": "Vpu protein indicating that CBF regulates Vif Kinetic revealed effects CBF both on rate Vif biosynthesis. These were dependent on ability of CBF to interact with pointing to a chaperone function of CBF. Importantly", "change_char_case": " Vpu protein indicating that CbF regulateS Vif eXprEssIoN posT-traNscriptionally. kInetIc studies revealed effecTs of CbF BOth oN MeTabolIc stabiLItY ANd oN tHe RatE oF viF biosYntHesis. ThEse effects WerE dEpendent on thE AbIlity of CBF To iNteract with VIf pOintinG tO a cHAperoNe fUnctiOn of CBf. importAntly", "whitespace_perturbation": " Vpu protein indicating th at CBF reg ulate s V ifex pres sion  post-transcri p tion ally. Kinetic studiesrevea le d  eff e ct s ofCBF bot h  o n met ab ol icst a bi lityand  on the  rate of V ifbi osynthesis.T he se effects  we re dependent  on  the a bi lit y  of C BFto in teract with V if pointi ng to a c h aperone f un ctio n of CBF. Importa n tl y ", "underscore_trick": " Vpu_protein indicating_that CBF regulates Vif_expression post-transcriptionally._Kinetic_studies revealed_effects_of CBF both_on metabolic stability_and on the rate_of Vif biosynthesis._These_effects were dependent on the ability of CBF to interact with Vif pointing to_a_chaperone function_of_CBF._Importantly"}
{"text": " shown to be related to immunologic and pro-inflammatory factors. Circulating microbial products such as LPS and markers associated with microbial translocation have been shown to play an important role in disease pathogenesis of certain infections like HIV. Similarly, proteins associated with the acute phase response and related cytokines also play an important role in pathogenesis. We", "synonym_substitution": "shown to be related to immunologic and pro - inflammatory divisor. circulate microbial products such as LPS and markers associated with microbial translocation have been prove to play an important function in disease pathogenesis of certain infections like HIV. Similarly, protein consociate with the acute phase reply and related cytokines also toy an important role in pathogenesis. We", "butter_fingers": " shlwn to be related to immmnologic and pro-nbflammetory fzctors. Ckrculating microbial productd wuch qs LPS and markers assuciated wpth microvial rranslocatmkn have been amown co play an imporjant role in disease pathocevedis of certain infections like HIV. Fimilarky, proteins assosiattd rith nht acute phase response and relates cytokpnes also play an important role in pathogejesid. We", "random_deletion": "shown to be related to immunologic and Circulating products such LPS and markers been to play an role in disease of certain infections like HIV. Similarly, associated with the acute phase response and related cytokines also play an important in pathogenesis. We", "change_char_case": " shown to be related to immunolOgic and pro-InflaMmaTorY fActoRs. CiRculating microBIal pRoducts such as LPS and marKers aSsOCiatED wIth miCrobial TRaNSLocAtIoN haVe BEeN showN to Play an iMportant roLe iN dIsease pathogENeSis of certaIn iNfections likE HIv. SimilArLy, pROteinS asSociaTed witH The acuTe phase reSpONse and RElated cYTOkInes Also play an importaNT rOLe in pathogenesIs. We", "whitespace_perturbation": " shown to be related to im munologicand p ro- inf la mmat oryfactors. Circu l atin g microbial products s uch a sL PS a n dmarke rs asso c ia t e d w it hmic ro b ia l tra nsl ocation  have been  sh ow n to play an im portant ro lein disease p ath ogenes is  of certa ininfec tionsl ike HI V. Simila rl y , prot e ins ass o c ia tedwith the acute ph a se response and r elated  c y to k i nes  al so play an  i mport a nt role in p a tho g enesis. We", "underscore_trick": " shown_to be_related to immunologic and_pro-inflammatory factors._Circulating_microbial products_such_as LPS and_markers associated with_microbial translocation have been_shown to play_an_important role in disease pathogenesis of certain infections like HIV. Similarly, proteins associated with_the_acute phase_response_and_related cytokines also play an_important role in pathogenesis. We"}
{"text": " used transgenic rescue constructs containing genes from the region that were wildtype or individually mutated. This showed that, for ED1, the critical gene is glutathione-S-transferase S1 (GstS1). In Drosophila this enzyme functions as an antioxidant, implicating redox regulation as an important contributor to anesthetic sensitivity.", "synonym_substitution": "used transgenic rescue constructs containing genes from the area that were wildtype or individually mutate. This show that, for ED1, the critical gene is glutathione - S - transferase S1 (GstS1). In Drosophila this enzyme function as an antioxidant, entail redox regulation as an important subscriber to anesthetic sensitivity.", "butter_fingers": " usfd transgenic rescue conrtructs containnbg genxs from the regkon that were wildtype or invivieuallt mutated. This showed ghat, for VD1, the cruticel gene is glutavgione-S-tvcnsfedwse V1 (GstS1). In Drosokhila this etzyme functionv xs an antioxidant, implicating redox rqgulatipn as an importagt cpgtrigltir to anesthetic sensitivity.", "random_deletion": "used transgenic rescue constructs containing genes from that wildtype or mutated. This showed gene glutathione-S-transferase S1 (GstS1). Drosophila this enzyme as an antioxidant, implicating redox regulation an important contributor to anesthetic sensitivity.", "change_char_case": " used transgenic rescue constRucts contaIning GenEs fRoM the RegiOn that were wildTYpe oR individually mutated. ThIs shoWeD That, FOr eD1, the CriticaL GeNE Is gLuTaThiOnE-s-tRansfEraSe S1 (GstS1). in DrosophiLa tHiS enzyme functIOnS as an antioXidAnt, implicatiNg rEdox reGuLatIOn as aN imPortaNt contRIbutor To anestheTiC SensitIVity.", "whitespace_perturbation": " used transgenic rescue co nstructs c ontai nin g g en es f romthe region tha t  wer e wildtype or individu allymu t ated .  T his s howed t h at , for  E D1 , t he cr itica l g ene isglutathion e-S -t ransferase S 1  ( GstS1). In  Dr osophila thi s e nzymefu nct i ons a s a n ant ioxida n t, imp licatingre d ox reg u lationa s  a n im portant contribut o rt o anesthetic s ensiti vi t y. ", "underscore_trick": " used_transgenic rescue_constructs containing genes from_the region_that_were wildtype_or_individually mutated. This_showed that, for_ED1, the critical gene_is glutathione-S-transferase S1_(GstS1)._In Drosophila this enzyme functions as an antioxidant, implicating redox regulation as an important_contributor_to anesthetic_sensitivity."}
{"text": " self-renewing stem cell population and a quiescent stem cell population. The self-renewing stem cells highly express Lgr5 and reside between Paneth cells at the crypt base where Wnt signaling is active whereas quiescent stem cells express Bmi1 and reside at the position 4. Thus the lineage-specific precursor", "synonym_substitution": "self - renewing stem cell population and a quiescent stem cellular telephone population. The self - regenerate stem cells highly carry Lgr5 and rest between Paneth cells at the crypt base where Wnt bespeak is active whereas quiescent bow cells carry Bmi1 and reside at the position 4. therefore the lineage - specific precursor", "butter_fingers": " sepf-renewing stem cell popmlation and a qunwscent stem dell popjlation. The self-renewing stel xells highly express Lgr5 ana reside hetween Paneuh cells at the ccgpt basc whedc Wnt wignaling is agtive whereds quiescent sdeo eells express Bmi1 and reside at the [ositiom 4. Thus the linewge-skecyfic irtcursor", "random_deletion": "self-renewing stem cell population and a quiescent population. self-renewing stem highly express Lgr5 at crypt base where signaling is active quiescent stem cells express Bmi1 and at the position 4. Thus the lineage-specific precursor", "change_char_case": " self-renewing stem cell populAtion and a qUiescEnt SteM cEll pOpulAtion. The self-reNEwinG stem cells highly expresS Lgr5 aNd REsidE BeTween paneth cELlS AT thE cRyPt bAsE WhEre WnT siGnaling Is active whEreAs Quiescent steM CeLls express bmi1 And reside at tHe pOsitioN 4. THus THe linEagE-specIfic prECursor", "whitespace_perturbation": " self-renewing stem cell p opulationand a  qu ies ce nt s temcell populatio n . Th e self-renewing stem c ellshi g hlye xp ressLgr5 an d  r e s ide  b et wee nP an eth c ell s at th e crypt ba sewh ere Wnt sign a li ng is acti vewhereas quie sce nt ste mcel l s exp res s Bmi 1 andr esideat the po si t ion 4. Thus th e li neag e-specific precur s or ", "underscore_trick": " self-renewing_stem cell_population and a quiescent_stem cell_population._The self-renewing_stem_cells highly express_Lgr5 and reside_between Paneth cells at_the crypt base_where_Wnt signaling is active whereas quiescent stem cells express Bmi1 and reside at the_position_4. Thus_the_lineage-specific_precursor"}
{"text": "M as well as in eggs and chickens. In AGM, two doses of NDV-HA induced a substantial titer of HPAIV-neutralizing serum antibodies;in addition, a substantial respiratory mucosal IgA response was induced following one and two doses, which would be particularly important in controlling a respiratory pathogen. We", "synonym_substitution": "M as well as in eggs and chickens. In AGM, two venereal disease of NDV - HA induce a substantial titer of HPAIV - neutralizing serum antibodies;in addition, a hearty respiratory mucosal IgA response was induced surveil one and two doses, which would be particularly significant in controlling a respiratory pathogen. We", "butter_fingers": "M ad well as in eggs and chlckens. In AGM, two doses of NDB-HA induzed a substantial titer of H'AIV-beutrqlizing serum antibodids;in addinion, a suvstaitial respiratorb mucosal IgA dcsponvx was induced fpllowing ote and two dosas, wkich would be particularly important in conyrllling a respitatorj [athkgen. We", "random_deletion": "M as well as in eggs and AGM, doses of induced a substantial addition, substantial respiratory mucosal response was induced one and two doses, which would particularly important in controlling a respiratory pathogen. We", "change_char_case": "M as well as in eggs and chickenS. In AGM, two dOses oF NDv-HA InDuceD a suBstantial titer OF HPAiV-neutralizing serum antIbodiEs;IN addITiOn, a suBstantiAL rESPirAtOrY muCoSAl igA reSpoNse was iNduced follOwiNg One and two dosES, wHich would bE paRticularly imPorTant in CoNtrOLling A reSpiraTory paTHogen. WE", "whitespace_perturbation": "M as well as in eggs and c hickens. I n AGM , t wodo sesof N DV-HA induceda  sub stantial titer of HPAI V-neu tr a lizi n gserum  antibo d ie s ; inad di tio n, asubst ant ial res piratory m uco sa l IgA respon s ewas induce d f ollowing one  an d twodo ses ,  whic h w ouldbe par t icular ly import an t  in co n trollin g aresp iratory pathogen. We ", "underscore_trick": "M as_well as_in eggs and chickens._In AGM,_two_doses of_NDV-HA_induced a substantial_titer of HPAIV-neutralizing_serum antibodies;in addition, a_substantial respiratory mucosal_IgA_response was induced following one and two doses, which would be particularly important in_controlling_a respiratory_pathogen._We"}
{"text": "ords a unique opportunity to prospectively study lagged effects of three types of cognitive interventions on functional decline in this well-characterized cohort that, given its advancing age, is now at imminent risk for both IADL and ADL decline. We will be able to test the basic question in this study: For older adults", "synonym_substitution": "ords a unique opportunity to prospectively study lagged effects of three type of cognitive interposition on functional decline in this well - characterized age group that, given its advancing age, is nowadays at imminent risk for both IADL and ADL decay. We will be able to test the basic question in this sketch: For older adults", "butter_fingers": "ordd a unique opportunity tu prospectively study nagged effects of three types of cognitive ibtervtutions on functional decline pn this wwll-ciaracterized cohort that, given lts abvencing age, is npw at immitent risk for togh IADL and ADL decline. We will be abje to trsh the basic qugstiom in fhis study: For older adults", "random_deletion": "ords a unique opportunity to prospectively study of types of interventions on functional that, its advancing age, now at imminent for both IADL and ADL decline. will be able to test the basic question in this study: For older", "change_char_case": "ords a unique opportunity to pRospectiveLy stuDy lAggEd EffeCts oF three types of cOGnitIve interventions on funcTionaL dEClinE In This wEll-charACtERIzeD cOhOrt ThAT, gIven iTs aDvancinG age, is now aT imMiNent risk for bOTh iADL and ADL DecLine. We will be AblE to tesT tHe bASic quEstIon in This stUDy: For oLder adultS", "whitespace_perturbation": "ords a unique opportunityto prospec tivel y s tud ylagg ed e ffects of thre e  typ es of cognitive interv entio ns on f u nc tiona l decli n ei n  th is  w ell -c h ar acter ize d cohor t that, gi ven  i ts advancing ag e, is nowatimminent ris k f or bot hIAD L  andADL  decl ine. W e  willbe able t ot est th e  basicq u es tion  in this study: F o ro lder adults", "underscore_trick": "ords a_unique opportunity_to prospectively study lagged_effects of_three_types of_cognitive_interventions on functional_decline in this_well-characterized cohort that, given_its advancing age,_is_now at imminent risk for both IADL and ADL decline. We will be able_to_test the_basic_question_in this study: For older_adults"}
{"text": " with GluR1, as well as their multi-meric structure. 5. Compensatory endocytosis is a distinct form of endocytosis that compensates for exocytotic activity. It plays an essential role in the maintenance of cell surface homeostasis. In our fifth project we have developed a new imaging based assay for testing", "synonym_substitution": "with GluR1, as well as their multi - meric structure. 5. Compensatory endocytosis is a distinct form of endocytosis that cover for exocytotic natural process. It plays an essential role in the alimony of cell surface homeostasis. In our fifth undertaking we have developed a new imaging establish assay for testing", "butter_fingers": " wihh GluR1, as well as their multi-meric strocrure. 5. Rompensztory enaocytosis is a distinct form od endicytosis that compensages for eqocytotic actmvity. It plays ai essentlcl romc in chx maintenance on cell surfdce homeostasiv. Kn our fifth project we have developeq a new ilaging based afsay sor fvsuing", "random_deletion": "with GluR1, as well as their multi-meric Compensatory is a form of endocytosis It an essential role the maintenance of surface homeostasis. In our fifth project have developed a new imaging based assay for testing", "change_char_case": " with GluR1, as well as their multI-meric struCture. 5. comPenSaTory EndoCytosis is a distINct fOrm of endocytosis that coMpensAtES for EXoCytotIc activITy. iT PlaYs An EssEnTIaL role In tHe maintEnance of ceLl sUrFace homeostaSIs. in our fifth ProJect we have deVelOped a nEw ImaGIng baSed Assay For tesTIng", "whitespace_perturbation": " with GluR1, as well as th eir multi- meric  st ruc tu re.5. C ompensatory en d ocyt osis is a distinct for m ofen d ocyt o si s tha t compe n sa t e s f or  e xoc yt o ti c act ivi ty. Itplays an e sse nt ial role int he  maintenan ceof cell surf ace  homeo st asi s . Inour  fift h proj e ct wehave deve lo p ed a n e w imagi n g  b ased  assay for testin g ", "underscore_trick": " with_GluR1, as_well as their multi-meric_structure. 5._Compensatory_endocytosis is_a_distinct form of_endocytosis that compensates_for exocytotic activity. It_plays an essential_role_in the maintenance of cell surface homeostasis. In our fifth project we have developed_a_new imaging_based_assay_for testing"}
{"text": " with age, there are global and regional changes in cortical volume, thickness and surface area. Age-related atrophy, in most cortical regions was indicated by a reduction in thickness however, most striking was that the prefrontal cortex showed a reduced thickness, surface area, in addition to volume which confirmed previously published reports. Interestingly, the", "synonym_substitution": "with age, there are global and regional changes in cortical bulk, thickness and open area. Age - related atrophy, in most cortical area was indicated by a reduction in thickness however, about striking was that the prefrontal cortex showed a boil down thickness, surface area, in summation to volume which confirmed previously published reputation. Interestingly, the", "butter_fingers": " wihh age, there are global xnd regional chcbges ii cortidal voluoe, thickness and surface aree. Agw-relauvd atrophy, in most coftical rehions waw invicated by a redndtion ik thidnnesv however, most xtriking wds that the praffoutal cortex showed a reduced thicknefs, surfscf area, in addijion uo dolujv chich confirmed previously publjshed rtports. Interestingky, the", "random_deletion": "with age, there are global and regional cortical thickness and area. Age-related atrophy, indicated a reduction in however, most striking that the prefrontal cortex showed a thickness, surface area, in addition to volume which confirmed previously published reports. Interestingly,", "change_char_case": " with age, there are global and rEgional chaNges iN coRtiCaL volUme, tHickness and surFAce aRea. Age-related atrophy, in Most cOrTIcal REgIons wAs indicATeD BY a rEdUcTioN iN ThIckneSs hOwever, mOst strikinG waS tHat the prefroNTaL cortex shoWed A reduced thicKneSs, surfAcE arEA, in adDitIon to Volume WHich coNfirmed prEvIOusly pUBlished REPoRts. INterestingly, the", "whitespace_perturbation": " with age, there are globa l and regi onalcha nge sin c orti cal volume, th i ckne ss and surface area. A ge-re la t ed a t ro phy,in most co r t ica lre gio ns wa s ind ica ted bya reductio n i nthickness ho w ev er, most s tri king was tha t t he pre fr ont a l cor tex  show ed a r e ducedthickness ,s urface area, i n ad diti on to volume whic h  c o nfirmed previo usly p ub l is h e d r epo rts. Inter es tingl y , the", "underscore_trick": " with_age, there_are global and regional_changes in_cortical_volume, thickness_and_surface area. Age-related_atrophy, in most_cortical regions was indicated_by a reduction_in_thickness however, most striking was that the prefrontal cortex showed a reduced thickness, surface_area,_in addition_to_volume_which confirmed previously published reports._Interestingly, the"}
{"text": " are gammaretroviruses linked to induction of neoplasms and to neurological and immunodeficiency diseases. Inbred strains of laboratory mice and wild mouse species differ in their susceptibility to mouse gammaretrovirus infection and to virus-induced diseases, and they also differ in the types of MLVs that they carry. Susceptibility", "synonym_substitution": "are gammaretroviruses linked to induction of neoplasms and to neurological and immunodeficiency diseases. Inbred tune of lab mice and wild mouse coinage differ in their susceptibility to mouse gammaretrovirus infection and to virus - induce diseases, and they also disagree in the type of MLVs that they carry. Susceptibility", "butter_fingers": " arf gammaretroviruses linktd to induction oy neoplesms ans to neufological and immunodeficienry duseastf. Inbred strains ow laboratlry mice and qild mouse species diffed in chxir susceptibillty to mousa gammaretrovisur nnfection and to virus-induced diseasqs, and yhfy also differ in uhe typss of MLVs that they carry. Susceptjbility", "random_deletion": "are gammaretroviruses linked to induction of neoplasms neurological immunodeficiency diseases. strains of laboratory differ their susceptibility to gammaretrovirus infection and virus-induced diseases, and they also differ the types of MLVs that they carry. Susceptibility", "change_char_case": " are gammaretroviruses linkeD to inductiOn of nEopLasMs And tO neuRological and imMUnodEficiency diseases. InbreD straInS Of laBOrAtory Mice and WIlD MOusE sPeCieS dIFfEr in tHeiR suscepTibility to MouSe GammaretroviRUs Infection aNd tO virus-induceD diSeases, AnD thEY also DifFer in The typES of MLVS that they CaRRy. SuscEPtibiliTY", "whitespace_perturbation": " are gammaretroviruses lin ked to ind uctio n o f n eo plas ms a nd to neurolog i caland immunodeficiency d iseas es .  Inb r ed  stra ins ofl ab o r ato ry  m ice  a n dwildmou se spec ies differ  in  t heir suscept i bi lity to mo use  gammaretrov iru s infe ct ion and t o v irus- induce d  disea ses, andth e y also differi n  t he t ypes of MLVs that th e y carry. Susce ptibil it y ", "underscore_trick": " are_gammaretroviruses linked_to induction of neoplasms_and to_neurological_and immunodeficiency_diseases._Inbred strains of_laboratory mice and_wild mouse species differ_in their susceptibility_to_mouse gammaretrovirus infection and to virus-induced diseases, and they also differ in the types_of_MLVs that_they_carry._Susceptibility"}
{"text": " diagnosis of LAD-1. Cells were transduced ex vivo with FV-hCD18 for 16 hours. Flow cytometry of CD34+ cells cultured for 3 days after transduction demonstrated CD18+ cell surface expression in 39-42% of cells. Genetic correction of HSPCs from LAD-1 patients restored", "synonym_substitution": "diagnosis of LAD-1. Cells were transduced ex vivo with FV - hCD18 for 16 hours. menstruate cytometry of CD34 + cell cultured for 3 days after transduction demonstrated CD18 + cellular telephone surface expression in 39 - 42% of cells. familial correction of HSPCs from LAD-1 patients restore", "butter_fingers": " diwgnosis of LAD-1. Cells wert transduced ex vnco witi FV-hCD18 for 16 hojrs. Flow cytometry of CD34+ celps cultyred for 3 days after tfansductiln demonwtraued CD18+ cell surfars expression jk 39-42% of rells. Genetic cprrection mf HSPCs from NAA-1 'atients restored", "random_deletion": "diagnosis of LAD-1. Cells were transduced ex FV-hCD18 16 hours. cytometry of CD34+ after demonstrated CD18+ cell expression in 39-42% cells. Genetic correction of HSPCs from patients restored", "change_char_case": " diagnosis of LAD-1. Cells were trAnsduced ex Vivo wIth fV-hcD18 For 16 hOurs. flow cytometry oF cD34+ ceLls cultured for 3 days afteR tranSdUCtioN DeMonstRated CD18+ CElL SUrfAcE eXprEsSIoN in 39-42% of CelLs. GenetIc correctiOn oF HsPCs from LAD-1 pATiEnts restorEd", "whitespace_perturbation": " diagnosis of LAD-1. Cells  were tran sduce d e x v iv o wi th F V-hCD18 for 16 hour s. Flow cytometry of C D34+ce l ls c u lt uredfor 3 d a ys a fte rtr ans du c ti on de mon strated  CD18+ cel l s ur face express i on  in 39-42%  of  cells. Gene tic  corre ct ion of HS PCs  from  LAD-1 patien ts restor ed ", "underscore_trick": " diagnosis_of LAD-1._Cells were transduced ex_vivo with_FV-hCD18_for 16_hours._Flow cytometry of_CD34+ cells cultured_for 3 days after_transduction demonstrated CD18+_cell_surface expression in 39-42% of cells. Genetic correction of HSPCs from LAD-1 patients restored"}
{"text": "202G/M204V arises because of the sustained interactions of the cyano group of CMCP-TP with Leu180 in the RT of HBVWT as well as with the substituted amino acid Met180 in the RT of HBVETV-RL180M/S202G/M204V. We are", "synonym_substitution": "202G / M204V arises because of the sustained interactions of the cyano group of CMCP - TP with Leu180 in the RT of HBVWT as well as with the substitute amino acid Met180 in the RT of HBVETV - RL180M / S202G / M204V. We are", "butter_fingers": "202G/M204V arises because of the smstained interacjiins of the cgano grojp of CMCP-TP with Leu180 in the RR of YBVWT as well as with ghe substptuted amuno ecid Met180 in the CF of HBYZTV-RL180J/D202G/M204V. Xe are", "random_deletion": "202G/M204V arises because of the sustained interactions cyano of CMCP-TP Leu180 in the as the substituted amino Met180 in the of HBVETV-RL180M/S202G/M204V. We are", "change_char_case": "202G/M204V arises because of the sustAined interActioNs oF thE cYano GrouP of CMCP-TP with LEU180 in tHe RT of HBVWT as well as witH the sUbSTituTEd Amino Acid Met180 IN tHE rT oF HbVeTV-rL180m/s202G/m204V. We aRe", "whitespace_perturbation": "202G/M204V arises becauseof the sus taine d i nte ra ctio ns o f the cyano gr o up o f CMCP-TP with Leu180in th eR T of HB VWT a s wella sw i thth esub st i tu ted a min o acidMet180 inthe  R T of HBVETV- R L1 80M/S202G/ M20 4V. We are", "underscore_trick": "202G/M204V arises_because of_the sustained interactions of_the cyano_group_of CMCP-TP_with_Leu180 in the_RT of HBVWT_as well as with_the substituted amino_acid_Met180 in the RT of HBVETV-RL180M/S202G/M204V. We are"}
{"text": " as a full-length, 55-kDa receptor within the context of membranes of exosome-like vesicles. Thus, the constitutive release of TNFR1 exosome-like vesicles represents a novel pathway for the generation of soluble cytokine receptors that is distinct from the proteolytic cleavage of receptor ectodomains or the production of", "synonym_substitution": "as a full - length, 55 - kDa receptor within the context of membranes of exosome - alike vesicle. Thus, the constitutive dismissal of TNFR1 exosome - comparable vesicles represents a fresh pathway for the generation of soluble cytokine receptors that is discrete from the proteolytic cleavage of receptor ectodomains or the production of", "butter_fingers": " as a full-length, 55-kDa receptur within the context mf memgranes ow exosome-like vesicles. Thus, vhe xonstututive release of TNFF1 exosome-pike vesuclew represents a novel pathswy fmc the generatiok of solubla cytokine recapgoxs that is distinct from the proteolrtic clragage of receptjr ebtjdomzpnw or the production of", "random_deletion": "as a full-length, 55-kDa receptor within the membranes exosome-like vesicles. the constitutive release a pathway for the of soluble cytokine that is distinct from the proteolytic of receptor ectodomains or the production of", "change_char_case": " as a full-length, 55-kDa receptor wIthin the coNtext Of mEmbRaNes oF exoSome-like vesiclES. ThuS, the constitutive releasE of TNfR1 EXosoME-lIke veSicles rEPrESEntS a NoVel PaTHwAy for The GeneratIon of solubLe cYtOkine receptoRS tHat is distiNct From the proteOlyTic cleAvAge OF recePtoR ectoDomainS Or the pRoduction Of", "whitespace_perturbation": " as a full-length, 55-kDareceptor w ithin  th e c on text  ofmembranes of e x osom e-like vesicles. Thus,  theco n stit u ti ve re lease o f  T N F R1ex os ome -l i ke  vesi cle s repre sents a no vel  p athway for t h egeneration  of  soluble cyt oki ne rec ep tor s  that  is  dist inct f r om the  proteoly ti c  cleav a ge of r e c ep torectodomains or th e  p r oduction of", "underscore_trick": " as_a full-length,_55-kDa receptor within the_context of_membranes_of exosome-like_vesicles._Thus, the constitutive_release of TNFR1_exosome-like vesicles represents a_novel pathway for_the_generation of soluble cytokine receptors that is distinct from the proteolytic cleavage of receptor_ectodomains_or the_production_of"}
{"text": " feeding these parasites to laboratory-reared mosquitoes in the presence or absence of specific antibodies, and later counting oocysts in the mosquito midgut. To accelerate the development of transmission blocking vaccine, this year we have qualified the MFA to test its reproducibility. Using these results we have worked with Dr. Michael Fay", "synonym_substitution": "feeding these parasites to laboratory - reared mosquito in the bearing or absence of specific antibody, and later counting oocysts in the mosquito midgut. To accelerate the development of infection blocking vaccine, this year we have qualified the MFA to quiz its reproducibility. use these results we have ferment with Dr. Michael Fay", "butter_fingers": " fefding these parasites to laboratory-reargd mosqumtoes ih the prdsence or absence of specifir anribodues, and later counting oocysts pn the mowquiuo midgut. To accelerate tmz devspopmznv of transmissipn blockinc vaccine, this ydax we have qualified the MFA to test yts reptofucibility. Usigg tnqse dvsmlts we have worked with Dr. Michzel Fay", "random_deletion": "feeding these parasites to laboratory-reared mosquitoes in or of specific and later counting To the development of blocking vaccine, this we have qualified the MFA to its reproducibility. Using these results we have worked with Dr. Michael Fay", "change_char_case": " feeding these parasites to laBoratory-reAred mOsqUitOeS in tHe prEsence or absencE Of spEcific antibodies, and latEr couNtINg ooCYsTs in tHe mosquITo MIDguT. TO aCceLeRAtE the dEveLopment Of transmisSioN bLocking vacciNE, tHis year we hAve Qualified the mFA To test ItS rePRoducIbiLity. USing thESe resuLts we have WoRKed witH dr. MichaEL faY", "whitespace_perturbation": " feeding these parasites t o laborato ry-re are d m os quit oesin the presenc e  orabsence of specific an tibod ie s , an d  l atercountin g  o o c yst sin  th em os quito  mi dgut. T o accelera teth e developmen t  o f transmis sio n blocking v acc ine, t hi s y e ar we  ha ve qu alifie d  the M FA to tes ti ts rep r oducibi l i ty . Us ing these results we have worked wi th Dr.  M i ch a e l F ay", "underscore_trick": " feeding_these parasites_to laboratory-reared mosquitoes in_the presence_or_absence of_specific_antibodies, and later_counting oocysts in_the mosquito midgut. To_accelerate the development_of_transmission blocking vaccine, this year we have qualified the MFA to test its reproducibility._Using_these results_we_have_worked with Dr. Michael Fay"}
{"text": "5hi cells) that are best able to recognize foreign antigens, but to prevent pathogen escape from detection, there is a secondary repertoire that diversifies from this germline set using TdT nucleotide additions; these cells on average are less avid for antigen, but provide breadth of coverage. Tests of this model are underway using", "synonym_substitution": "5hi cells) that are best able to recognize foreign antigen, but to prevent pathogen evasion from detection, there is a junior-grade repertoire that diversifies from this germline typeset using TdT nucleotide additions; these cellular telephone on average are less avid for antigen, but provide width of coverage. examination of this model are afoot using", "butter_fingers": "5hi fells) that are best able to recognize foreign entigena, but to prevent pathogen escape frol eetecupon, there is a secondxry repernoire thar ditersifies from tijs germline ssb usiug TdT nucleotidg additions; dhese cells on axexage are less avid for antigen, but pwovide nrfadth of coverwge. Ueses or this model are underway using", "random_deletion": "5hi cells) that are best able to antigens, to prevent escape from detection, that from this germline using TdT nucleotide these cells on average are less for antigen, but provide breadth of coverage. Tests of this model are underway", "change_char_case": "5hi cells) that are best able to rEcognize foReign AntIgeNs, But tO preVent pathogen esCApe fRom detection, there is a seCondaRy REperTOiRe thaT diversIFiES FroM tHiS geRmLInE set uSinG TdT nucLeotide addItiOnS; these cells oN AvErage are leSs aVid for antigeN, buT proviDe BreADth of CovErage. tests oF This moDel are undErWAy usinG", "whitespace_perturbation": "5hi cells) that are best a ble to rec ogniz e f ore ig n an tige ns, but to pre v entpathogen escape from d etect io n , th e re  is a  second a ry r epe rt oi reth a tdiver sif ies fro m this ger mli ne  set using T d Tnucleotide  ad ditions; the secellson  av e rageare  less  avidf or ant igen, but  p r ovideb readtho f  c over age. Tests of thi s  m o del are underw ay usi ng ", "underscore_trick": "5hi cells)_that are_best able to recognize_foreign antigens,_but_to prevent_pathogen_escape from detection,_there is a_secondary repertoire that diversifies_from this germline_set_using TdT nucleotide additions; these cells on average are less avid for antigen, but_provide_breadth of_coverage._Tests_of this model are underway_using"}
{"text": "; some of these aptamers inhibit parasite growth in vitro. This year we have completed broader studies on the reactivity profiles of this subset and shown that some recognize all the parasite isolates tested. More recently we have developed methods to affinity purify the parasite targets of the aptamers. This is a complex process, involving preparation of", "synonym_substitution": "; some of these aptamers inhibit parasite growth in vitro. This year we have completed broad cogitation on the reactivity profile of this subset and prove that some recognize all the parasite isolates test. More recently we have develop methods to affinity purify the parasite target of the aptamers. This is a complex process, involving training of", "butter_fingers": "; sole of these aptamers inhlbit parasite growth in vitro. This yexr we have completed broader srudiew on the reactivity prufiles of this suvset qnd shown vgat somc recknnize ell the parasitg isolates tasted. More recanglv we have developed methods to affinyty purofj the parasite tarbqts kf the aptamers. This is a complex lrocess, involving prrparation of", "random_deletion": "; some of these aptamers inhibit parasite vitro. year we completed broader studies this and shown that recognize all the isolates tested. More recently we have methods to affinity purify the parasite targets of the aptamers. This is a process, involving preparation of", "change_char_case": "; some of these aptamers inhibiT parasite gRowth In vItrO. THis yEar wE have completed BRoadEr studies on the reactiviTy proFiLEs of THiS subsEt and shOWn THAt sOmE rEcoGnIZe All thE paRasite iSolates tesTed. moRe recently we HAvE developed MetHods to affiniTy pUrify tHe ParASite tArgEts of The aptAMers. ThIs is a compLeX ProcesS, InvolviNG PrEparAtion of", "whitespace_perturbation": "; some of these aptamers i nhibit par asite  gr owt hin v itro . This year we have  completed broader stu dieson ther ea ctivi ty prof i le s ofth is  su bs e tand s how n thatsome recog niz eall the para s it e isolates  te sted. More r ece ntly w ehav e  deve lop ed me thodst o affi nity puri fy the pa r asite t a r ge ts o f the aptamers. T h is is a complex p rocess ,i nv o l vin g p reparation  o f", "underscore_trick": "; some_of these_aptamers inhibit parasite growth_in vitro._This_year we_have_completed broader studies_on the reactivity_profiles of this subset_and shown that_some_recognize all the parasite isolates tested. More recently we have developed methods to affinity_purify_the parasite_targets_of_the aptamers. This is a_complex process, involving preparation of"}
{"text": ". Accounting for gender, our preliminary findings suggested that in both sexes, pubertal sex steroid deficiency contributes to persistent structural and functional brain differences as well as to neurocognitive deficits primarily involving spatial ability and recognition memory, providing direct evidence in humans about the critical spatiotemporal role played by appropriately timed pubert", "synonym_substitution": ". Accounting for gender, our preliminary findings suggested that in both sex, pubertal sexual activity steroid deficiency contribute to dogged structural and functional genius difference as well as to neurocognitive deficit primarily involving spatial ability and realization memory, providing direct evidence in humans about the critical spatiotemporal role play by appropriately timed pubert", "butter_fingers": ". Acfounting for gender, our kreliminary findiuts sugjested fhat in coth sexes, pubertal sex sterlie defuciency contributes to persistejt strucrurao and functmknal brain dirnereneew as well as tp neurocogtitive deficitv ornmarily involving spatial ability anq recogmihion memory, prjvidpnd didvcu evidence in humans about the crjtical vpatiotemporak role played by appropriahely timed pubert", "random_deletion": ". Accounting for gender, our preliminary findings in sexes, pubertal steroid deficiency contributes brain as well as neurocognitive deficits primarily spatial ability and recognition memory, providing evidence in humans about the critical spatiotemporal role played by appropriately timed pubert", "change_char_case": ". Accounting for gender, our preLiminary fiNdingS suGgeStEd thAt in Both sexes, puberTAl seX steroid deficiency contRibutEs TO perSIsTent sTructurAL aND FunCtIoNal BrAIn DiffeRenCes as weLl as to neurOcoGnItive deficitS PrImarily invOlvIng spatial abIliTy and rEcOgnITion mEmoRy, proViding DIrect eVidence in HuMAns aboUT the criTICaL spaTiotemporal role plAYeD By appropriatelY timed PuBErT", "whitespace_perturbation": ". Accounting for gender, o ur prelimi naryfin din gs  sug gest ed that in bot h  sex es, pubertal sex stero id de fi c ienc y  c ontri butes t o  p e r sis te nt  st ru c tu ral a ndfunctio nal braindif fe rences as we l las to neur oco gnitive defi cit s prim ar ily invol vin g spa tial a b ilityand recog ni t ion me m ory, pr o v id ingdirect evidence i n  h u mans about the  criti ca l  s p a tio tem poral role  p layed by appr o pr i a t ely timed pubert", "underscore_trick": ". Accounting_for gender,_our preliminary findings suggested_that in_both_sexes, pubertal_sex_steroid deficiency contributes_to persistent structural_and functional brain differences_as well as_to_neurocognitive deficits primarily involving spatial ability and recognition memory, providing direct evidence in humans_about_the critical_spatiotemporal_role_played by appropriately timed pubert"}
{"text": " analysis of several different human trials of various blood-stage vaccine candidates and in testing of preclinical animal sera. An important step forward has been made in collaboration with Dr. Simon Draper and colleagues (Oxford University), who are using recombinant adenoviruses encoding P. falciparum blood stage antigens. A new potential blood-stage vaccine", "synonym_substitution": "analysis of several different human trials of diverse rake - stage vaccine candidates and in testing of preclinical animal serum. An important step forward has been have in collaboration with Dr. Simon Draper and colleagues (Oxford University), who are using recombinant adenovirus encode P. falciparum blood stage antigen. A new potential lineage - stagecoach vaccine", "butter_fingers": " anwlysis of several differtnt human trials of varimus blkod-stage vaccine candidates and in txstibg of preclinical animal sefa. An implrtant srep horward has been made in collaglratnoi with Dr. Simon Draper ang colleagues (Offurb University), who are using recombinagt adenpvlruses encodind P. gwlcilarum blood stage antigens. A new pktentian blood-stage faccine", "random_deletion": "analysis of several different human trials of vaccine and in of preclinical animal has made in collaboration Dr. Simon Draper colleagues (Oxford University), who are using adenoviruses encoding P. falciparum blood stage antigens. A new potential blood-stage vaccine", "change_char_case": " analysis of several differenT human triaLs of vAriOus BlOod-sTage Vaccine candidaTEs anD in testing of preclinicaL animAl SEra. AN ImPortaNt step fORwARD haS bEeN maDe IN cOllabOraTion witH Dr. Simon DrApeR aNd colleagues (oXfOrd UniversIty), Who are using rEcoMbinanT aDenOVirusEs eNcodiNg P. falCIparum Blood stagE aNTigens. a New poteNTIaL bloOd-stage vaccine", "whitespace_perturbation": " analysis of several diffe rent human  tria lsofva riou s bl ood-stage vacc i ne c andidates and in testi ng of  p r ecli n ic al an imal se r a. A n i mp or tan ts te p for war d has b een made i n c ol laboration w i th  Dr. Simon  Dr aper and col lea gues ( Ox for d  Univ ers ity),  who a r e usin g recombi na n t aden o viruses e nc odin g P. falciparum b l oo d  stage antigen s. A n ew po t e nti alblood-stag evacci n e", "underscore_trick": " analysis_of several_different human trials of_various blood-stage_vaccine_candidates and_in_testing of preclinical_animal sera. An_important step forward has_been made in_collaboration_with Dr. Simon Draper and colleagues (Oxford University), who are using recombinant adenoviruses encoding_P._falciparum blood_stage_antigens._A new potential blood-stage vaccine"}
{"text": " and cross-lagged analyses of change using latent change analysis, structural equation modeling, and growth curve analyses will also be used as appropriate to characterize relationships between individual difference factors and change in functional competence. Retention is projected conservatively at 72% with 65% of the cohort providing full data and another 7% providing partial", "synonym_substitution": "and cross - lagged analyses of change use latent variety analysis, structural equality modeling, and emergence curve analyses will besides be use as appropriate to characterize relationship between individual difference factors and variety in functional competence. Retention is projected conservatively at 72% with 65% of the cohort provide full data and another 7% providing partial", "butter_fingers": " anf cross-lagged analyses on change using lcrent ciange ahalysis, rtructural equation modeling, abd griwth curve analyses wiul also bv used as appcopriate to charedterize relatjlnshnpw between indiyidual diffarence factors avd change in functional competence. Reeention id projected cogsernaeivemj ct 72% with 65% of the cohort providihg full data and anoyher 7% providing partial", "random_deletion": "and cross-lagged analyses of change using latent structural modeling, and curve analyses will to relationships between individual factors and change functional competence. Retention is projected conservatively 72% with 65% of the cohort providing full data and another 7% providing", "change_char_case": " and cross-lagged analyses of cHange using LatenT chAngE aNalySis, sTructural equatIOn moDeling, and growth curve anAlyseS wILl alSO bE used As approPRiATE to ChArActErIZe RelatIonShips beTween indivIduAl Difference faCToRs and changE in Functional coMpeTence. REtEntIOn is pRojEcted ConserVAtivelY at 72% with 65% of ThE Cohort PRovidinG FUlL datA and another 7% providINg PArtial", "whitespace_perturbation": " and cross-lagged analyses  of change  usin g l ate nt  cha ngeanalysis, stru c tura l equation modeling, a nd gr ow t h cu r ve  anal yses wi l la l sobe  u sed  a s  a pprop ria te to c haracteriz e r el ationships b e tw een indivi dua l difference  fa ctorsan d c h angeinfunct ionalc ompete nce. Rete nt i on isp rojecte d co nser vatively at 72% w i th 65% of the coh ort pr ov i di n g  fu lldata and a no ther7 % provi d in g p art i al", "underscore_trick": " and_cross-lagged analyses_of change using latent_change analysis,_structural_equation modeling,_and_growth curve analyses_will also be_used as appropriate to_characterize relationships between_individual_difference factors and change in functional competence. Retention is projected conservatively at 72% with_65%_of the_cohort_providing_full data and another 7%_providing partial"}
{"text": " metabolites and parse gray/white matter differences that impact interpretation of imaging results in clinical populations. There have been inconsistencies in the reproducibility of MRS studies that quantify GABA levels in vivo, such as field strength, scanning techniques, acquisition and processing which resulted in varied measures. GABA is a major inhibitory neurotransmitter in human brain and", "synonym_substitution": "metabolites and parse gray / white matter dispute that affect interpretation of imaging result in clinical population. There have been inconsistencies in the reproducibility of MRS studies that quantify GABA level in vivo, such as playing field strength, scan techniques, acquisition and processing which result in varied measures. GABA is a major inhibitory neurotransmitter in human brain and", "butter_fingers": " mehabolites and parse gray/dhite matter diyderencxs that impact knterpretation of imaging reduots ib clinical populations. There hane been ibconwustencies mh the rc'rodudlbilicy of MRS studiex that quattify GABA levalr nn vivo, such as field strength, scannyng tecnnlques, acquisityon sgd pdocessing which resulted in varied measurts. GABA is a major inhibitory neurotransmittfr ij human brain and", "random_deletion": "metabolites and parse gray/white matter differences that of results in populations. There have of studies that quantify levels in vivo, as field strength, scanning techniques, acquisition processing which resulted in varied measures. GABA is a major inhibitory neurotransmitter in brain and", "change_char_case": " metabolites and parse gray/whIte matter dIfferEncEs tHaT impAct iNterpretation oF ImagIng results in clinical poPulatIoNS. TheRE hAve beEn inconSIsTENciEs In The RePRoDucibIliTy of MRS Studies thaT quAnTify GABA leveLS iN vivo, such aS fiEld strength, sCanNing teChNiqUEs, acqUisItion And proCEssing Which resuLtED in varIEd measuRES. GaBA iS a major inhibitory NEuROtransmitter in Human bRaIN aND", "whitespace_perturbation": " metabolites and parse gra y/white ma tterdif fer en cesthat  impact interp r etat ion of imaging results  in c li n ical po pulat ions. T h er e hav ebe enin c on siste nci es in t he reprodu cib il ity of MRS s t ud ies that q uan tify GABA le vel s in v iv o,s uch a s f ieldstreng t h, sca nning tec hn i ques,a cquisit i o nandprocessing whichr es u lted in varied  measu re s .G A BAisa major in hi bitor y  neurot r an s m i tte r  in human bra in and", "underscore_trick": " metabolites_and parse_gray/white matter differences that_impact interpretation_of_imaging results_in_clinical populations. There_have been inconsistencies_in the reproducibility of_MRS studies that_quantify_GABA levels in vivo, such as field strength, scanning techniques, acquisition and processing which_resulted_in varied_measures._GABA_is a major inhibitory neurotransmitter_in human brain and"}
{"text": " scattering measurements. We applied our approach to understand the binding mechanism in glucose sensors made from smart zwitterionic hydrogels containing boronic acid moieties. Based on systematic SANS and osmotic pressure measurements we provided a thermodynamic explanation for the enhanced selectivity of these gels for glucose relative to fructose. This class of material has", "synonym_substitution": "scattering measurements. We applied our approach to sympathize the tie mechanism in glucose sensors make from bright zwitterionic hydrogels containing boronic acid moiety. base on systematic SANS and osmotic pressure measurements we provided a thermodynamic explanation for the enhance selectivity of these gels for glucose relative to fructose. This course of material has", "butter_fingers": " scwttering measurements. We applied our apkriach tm undedstand tfe binding mechanism in gluclsw senwors made from smart zditterionpc hydrogwls rontaining boronmd acid moietisd. Bavxd on systematig SANS and msmotic pressuse mzasurements we provided a thermodynaiic expkajation for the enhsgced selectivity of these gels for gludose renative to fruvtose. This class of materiwl hws", "random_deletion": "scattering measurements. We applied our approach to binding in glucose made from smart moieties. on systematic SANS osmotic pressure measurements provided a thermodynamic explanation for the selectivity of these gels for glucose relative to fructose. This class of material", "change_char_case": " scattering measurements. We aPplied our aPproaCh tO unDeRstaNd thE binding mechanISm in Glucose sensors made from Smart ZwITterIOnIc hydRogels cONtAINinG bOrOniC aCId MoietIes. based on Systematic sANs aNd osmotic preSSuRe measuremEntS we provided a TheRmodynAmIc eXPlanaTioN for tHe enhaNCed selEctivity oF tHEse gelS For glucOSE rElatIve to fructose. This CLaSS of material has", "whitespace_perturbation": " scattering measurements.We applied  ourapp roa ch  tounde rstand the bin d ingmechanism in glucose s ensor sm adef ro m sma rt zwit t er i o nic  h yd rog el s  c ontai nin g boron ic acid mo iet ie s. Based ons ys tematic SA NSand osmoticpre ssureme asu r ement s w e pro videda  therm odynamicex p lanati o n for t h e  e nhan ced selectivity o f  t h ese gels for g lucose  r e la t i vetofructose.Th is cl a ss of m a te r i a l h a s", "underscore_trick": " scattering_measurements. We_applied our approach to_understand the_binding_mechanism in_glucose_sensors made from_smart zwitterionic hydrogels_containing boronic acid moieties._Based on systematic_SANS_and osmotic pressure measurements we provided a thermodynamic explanation for the enhanced selectivity of_these_gels for_glucose_relative_to fructose. This class of_material has"}
{"text": " and heterozygous animals. No viable EpCAM-deficient pups were obtained. Assessment of embryos in timed pregnant females revealed that EpCAM-deficient embryos implanted and were indistinguishable from EpCAM-sufficient embryos until EGA 8.5 when they began to exhibit developmental delay. EpCAM-deficient embryos became nonviable and were", "synonym_substitution": "and heterozygous animals. No viable EpCAM - deficient pups were prevail. appraisal of embryos in timed pregnant female revealed that EpCAM - deficient embryo implant and were indistinguishable from EpCAM - sufficient embryos until EGA 8.5 when they began to exhibit developmental delay. EpCAM - insufficient embryos became nonviable and were", "butter_fingers": " anf heterozygous animals. Nu viable EpCAM-dgfucient pups sere obtxined. Assessment of embryos mn tumed kgegnant females reveaued that VpCAM-defixienu embryos implantxs and wcxe inslstinyumshable from EpGAM-sufficiett embryos unthl EYA 8.5 when they began to exhibit develjpmentak felay. EpCAM-defycieme emggyis became nonviable and were", "random_deletion": "and heterozygous animals. No viable EpCAM-deficient pups Assessment embryos in pregnant females revealed were from EpCAM-sufficient embryos EGA 8.5 when began to exhibit developmental delay. EpCAM-deficient became nonviable and were", "change_char_case": " and heterozygous animals. No vIable EpCAM-DeficIenT puPs Were ObtaIned. Assessment OF embRyos in timed pregnant femAles rEvEAled THaT EpCAm-deficiENt EMBryOs ImPlaNtED aNd werE inDistingUishable frOm EPCaM-sufficient EMbRyos until EgA 8.5 wHen they began To eXhibit DeVelOPmentAl dElay. EPCAM-deFIcient Embryos beCaME nonviABle and wERE", "whitespace_perturbation": " and heterozygous animals.  No viable  EpCA M-d efi ci entpups  were obtained .  Ass essment of embryos intimed  p r egna n tfemal es reve a le d tha tEp CAM -d e fi cient  em bryos i mplanted a ndwe re indisting u is hable from  Ep CAM-sufficie ntembryo sunt i l EGA  8. 5 whe n they beganto exhibi td evelop m ental d e l ay . Ep CAM-deficient emb r yo s  became nonvia ble an dw er e ", "underscore_trick": " and_heterozygous animals._No viable EpCAM-deficient pups_were obtained._Assessment_of embryos_in_timed pregnant females_revealed that EpCAM-deficient_embryos implanted and were_indistinguishable from EpCAM-sufficient_embryos_until EGA 8.5 when they began to exhibit developmental delay. EpCAM-deficient embryos became nonviable_and_were"}
{"text": "FC functional coupling with the hippocampus formation (HF) and to a lesser degree the rest of the PFC, in patients and siblings but not controls. Correlation between PFC activation and connectivity in the siblings was not detected, concluding that these events may be independent. The ZNF804A gene affects distributed network-based neuro", "synonym_substitution": "FC functional coupling with the hippocampus formation (HF) and to a lesser academic degree the remainder of the PFC, in patients and siblings but not control. correlation coefficient between PFC activation and connectivity in the siblings was not detected, conclude that these events may be independent. The ZNF804A gene affect distributed network - free-base neuro", "butter_fingers": "FC vunctional coupling with the hippocampus formavion (HF) and to x lesser degree the rest of vhe PFC, ib patients and siblingr but not controlw. Cocrelation betweei PFC acbnvatikk and ronnectivity in the siblitgs was not dedeztzd, concluding that these events may fe indelejdent. The ZNF804A gent asfecfs distributed network-based neuro", "random_deletion": "FC functional coupling with the hippocampus formation to lesser degree rest of the but controls. Correlation between activation and connectivity the siblings was not detected, concluding these events may be independent. The ZNF804A gene affects distributed network-based neuro", "change_char_case": "FC functional coupling with tHe hippocamPus foRmaTioN (Hf) and To a lEsser degree the REst oF the PFC, in patients and siBlingS bUT not COnTrols. correlaTIoN BEtwEeN PfC aCtIVaTion aNd cOnnectiVity in the sIblInGs was not deteCTeD, concludinG thAt these eventS maY be indEpEndENt. The zNF804a gene AffectS DistriButed netwOrK-Based nEUro", "whitespace_perturbation": "FC functional coupling wit h the hipp ocamp usfor ma tion  (HF ) and to a les s er d egree the rest of thePFC,in pati e nt s and  siblin g sb u t n ot  c ont ro l s.  Corr ela tion be tween PFCact iv ation and co n ne ctivity in  th e siblings w asnot de te cte d , con clu dingthat t h ese ev ents maybe indepe n dent. T h e  Z NF80 4A gene affects d i st r ibuted network -based  n e ur o ", "underscore_trick": "FC functional_coupling with_the hippocampus formation (HF)_and to_a_lesser degree_the_rest of the_PFC, in patients_and siblings but not_controls. Correlation between_PFC_activation and connectivity in the siblings was not detected, concluding that these events may_be_independent. The_ZNF804A_gene_affects distributed network-based neuro"}
{"text": " specific inhibition of endocytosis. It was also attenuated by cyclodextrin disruption of PM lipid micro-domain architecture, a change, which also retarded lateral diffusion and induced large clusters of HLA-I. In all, our data support a model for Nef downregulation of HLA-I that involves both major trafficking itineraries", "synonym_substitution": "specific inhibition of endocytosis. It was also attenuated by cyclodextrin disruption of PM lipid micro - domain computer architecture, a variety, which besides retarded lateral diffusion and induced big clusters of HLA - I. In all, our data subscribe a mannequin for Nef downregulation of HLA - I that involves both major traffic itineraries", "butter_fingers": " spfcific inhibition of enducytosis. It was also avtenuatsd by cyzlodextrin disruption of PM pipid mucro-domain architecturd, a changv, which aoso cetarded lateral diffusion and lnduczd large clusterx of HLA-I. Hn all, our datd ru'port a model for Nef downregulation of HLA-O hhat involves foth iajod trafficking itineraries", "random_deletion": "specific inhibition of endocytosis. It was also cyclodextrin of PM micro-domain architecture, a diffusion induced large clusters HLA-I. In all, data support a model for Nef of HLA-I that involves both major trafficking itineraries", "change_char_case": " specific inhibition of endocYtosis. It waS also AttEnuAtEd by CyclOdextrin disrupTIon oF PM lipid micro-domain arcHitecTuRE, a chANgE, whicH also reTArDED laTeRaL diFfUSiOn and IndUced larGe clusters Of HlA-i. In all, our datA SuPport a modeL foR Nef downreguLatIon of HlA-i thAT invoLveS both Major tRAffickIng itinerArIEs", "whitespace_perturbation": " specific inhibition of en docytosis.  It w asals oatte nuat ed by cyclodex t rindisruption of PM lipid  micr o- d omai n  a rchit ecture, ac h ang e,  w hic ha ls o ret ard ed late ral diffus ion  a nd induced l a rg e clusters  of  HLA-I. In a ll,  our d at a s u pport  amodel  for N e f down regulatio no f HLA- I  that i n v ol vesboth major traffi c ki n g itineraries", "underscore_trick": " specific_inhibition of_endocytosis. It was also_attenuated by_cyclodextrin_disruption of_PM_lipid micro-domain architecture,_a change, which_also retarded lateral diffusion_and induced large_clusters_of HLA-I. In all, our data support a model for Nef downregulation of HLA-I_that_involves both_major_trafficking_itineraries"}
{"text": "s and 7 metastatic liver lesions. Cluster analysis revealed that a subset of human HCC and all liver metastases shared a Met-induced expression signature. Furthermore, the presence of Met signature showed a significant correlation with increased vascular invasion rate, microvessel density, and decreased mean survival of HCC patients. We conclude that the genetically defined", "synonym_substitution": "s and 7 metastatic liver lesions. Cluster analysis revealed that a subset of human HCC and all liver metastasis partake a Met - induced expression touch. Furthermore, the bearing of Met signature showed a significant correlation coefficient with increase vascular invasion rate, microvessel concentration, and decrease mean survival of HCC affected role. We conclude that the genetically defined", "butter_fingers": "s ajd 7 metastatic liver leslons. Cluster analysis rxvealed that a rubset of human HCC and all picer mtnastases shared a Met-knduced eqpression sigiature. Furthermocs, the pvzsencs of Kxt signature shpwed a sigtificant correnagiln with increased vascular invasion rate, mocgovessel densijy, anc decdvawed mean survival of HCC patisnts. We conclude thay the genetically defined", "random_deletion": "s and 7 metastatic liver lesions. Cluster that subset of HCC and all expression Furthermore, the presence Met signature showed significant correlation with increased vascular invasion microvessel density, and decreased mean survival of HCC patients. We conclude that the defined", "change_char_case": "s and 7 metastatic liver lesionS. Cluster anAlysiS reVeaLeD thaT a suBset of human HCC ANd alL liver metastases shared A Met-iNdUCed eXPrEssioN signatURe. fURthErMoRe, tHe PReSence Of MEt signaTure showed A siGnIficant correLAtIon with incReaSed vascular iNvaSion raTe, MicROvessEl dEnsitY, and deCReased Mean surviVaL Of HCC pATients. WE COnCludE that the geneticalLY dEFined", "whitespace_perturbation": "s and 7 metastatic liver l esions. Cl uster  an aly si s re veal ed that a subs e t of  human HCC and all liv er me ta s tase s  s hared  a Met- i nd u c edex pr ess io n  s ignat ure . Furth ermore, th e p re sence of Met si gnature sh owe d a signific ant  corre la tio n  with  in creas ed vas c ular i nvasion r at e , micr o vesseld e ns ity,  and decreased me a ns urvival of HCC  patie nt s .W e  co ncl ude that t he  gene t icallyd ef i n e d", "underscore_trick": "s and_7 metastatic_liver lesions. Cluster analysis_revealed that_a_subset of_human_HCC and all_liver metastases shared_a Met-induced expression signature._Furthermore, the presence_of_Met signature showed a significant correlation with increased vascular invasion rate, microvessel density, and_decreased_mean survival_of_HCC_patients. We conclude that the_genetically defined"}
{"text": " the proteolytic cleavage and shedding of soluble TNFR1 ectodomains may have physiological relevance in the setting of oxidative stress, which has been associated with impaired proteasome function. The enhanced release of sTNFR1 ectodomains may also be important for patients receiving proteasome inhibitors as therapeutic agents for neoplastic disease. TNF-alpha", "synonym_substitution": "the proteolytic cleavage and shedding of soluble TNFR1 ectodomains may have physiological relevance in the setting of oxidative tension, which has been consociate with impaired proteasome function. The enhanced dismissal of sTNFR1 ectodomains may besides be important for patients receiving proteasome inhibitor as curative agents for neoplastic disease. TNF - alpha", "butter_fingers": " thf proteolytic cleavage akd shedding of soluble VNFR1 ecfodomainr may have physiological relxvanxe in the setting of oxidatkve stresd, which yas ueen associated xjth impaired lvoteavime function. Tme enhanced release of sTTFF1 zctodomains may also be important fow patiemtd receiving prjteaxjme jnhibitors as therapeutic agents fkr neopnastic diseasr. TNF-alpha", "random_deletion": "the proteolytic cleavage and shedding of soluble may physiological relevance the setting of associated impaired proteasome function. enhanced release of ectodomains may also be important for receiving proteasome inhibitors as therapeutic agents for neoplastic disease. TNF-alpha", "change_char_case": " the proteolytic cleavage and Shedding of SolubLe TnFR1 EcTodoMainS may have physioLOgicAl relevance in the settinG of oxIdATive STrEss, whIch has bEEn ASSocIaTeD wiTh IMpAired ProTeasome Function. ThE enHaNced release oF STnFR1 ectodomAinS may also be imPorTant foR pAtiENts reCeiVing pRoteasOMe inhiBitors as tHeRApeutiC Agents fOR NeOplaStic disease. TNF-alpHA", "whitespace_perturbation": " the proteolytic cleavageand sheddi ng of  so lub le  TNF R1 e ctodomains may have  physiological relevan ce in  t h e se t ti ng of  oxidat i ve s tre ss ,whi ch ha s bee n a ssociat ed with im pai re d proteasome fu nction. Th e e nhanced rele ase  of sT NF R1e ctodo mai ns ma y also be imp ortant fo rp atient s  receiv i n gprot easome inhibitors as therapeutic ag ents f or ne o p las tic  disease.TN F-alp h a", "underscore_trick": " the_proteolytic cleavage_and shedding of soluble_TNFR1 ectodomains_may_have physiological_relevance_in the setting_of oxidative stress,_which has been associated_with impaired proteasome_function._The enhanced release of sTNFR1 ectodomains may also be important for patients receiving proteasome_inhibitors_as therapeutic_agents_for_neoplastic disease. TNF-alpha"}
{"text": " larger families, we have identified a novel candidate gene for Kallmann syndrome (KS), which is characterized by IHH and anosmia. All affected individuals in this family carry a heterozygous nonsense variant in a gene whose function has been indirectly associated in animal models with the neuronal migration defect affecting GnRH neurons is responsible for the", "synonym_substitution": "larger families, we have identified a novel campaigner gene for Kallmann syndrome (KS), which is qualify by IHH and anosmia. All affected individuals in this syndicate impart a heterozygous nonsense variant in a gene whose routine has been indirectly consort in animal models with the neuronal migration defect affecting GnRH nerve cell is responsible for the", "butter_fingers": " lagger families, we have idtntified a novel eqndidave gene for Kalumann syndrome (KS), which is ciaraxterievd by IHH and anosmia. All affebted indiciduels in this family carry a hetsvozygmns nonsense varlant in a gane whose funcdiun has been indirectly associated in wnimal kofels with the geurpgal jpgvation defect affecting GnRH neudons is responsible gor the", "random_deletion": "larger families, we have identified a novel for syndrome (KS), is characterized by individuals this family carry heterozygous nonsense variant a gene whose function has been associated in animal models with the neuronal migration defect affecting GnRH neurons is for the", "change_char_case": " larger families, we have identIfied a noveL candIdaTe gEnE for kallMann syndrome (KS), WHich Is characterized by IHH anD anosMiA. all aFFeCted iNdividuALs IN ThiS fAmIly CaRRy A heteRozYgous noNsense variAnt In A gene whose fuNCtIon has been IndIrectly assocIatEd in anImAl mODels wIth The neUronal MIgratiOn defect aFfECting GNrH neuroNS Is RespOnsible for the", "whitespace_perturbation": " larger families, we haveidentified  a no vel  ca nd idat e ge ne for Kallman n  syn drome (KS), which is c harac te r ized by  IHHand ano s mi a .  Al laf fec te d  i ndivi dua ls in t his family  ca rr y a heterozy g ou s nonsense  va riant in a g ene  whose  f unc t ion h asbeenindire c tly as sociatedin animal modelsw i th  the  neuronal migrati o nd efect affectin g GnRH  n e ur o n s i s r esponsible  f or th e ", "underscore_trick": " larger_families, we_have identified a novel_candidate gene_for_Kallmann syndrome_(KS),_which is characterized_by IHH and_anosmia. All affected individuals_in this family_carry_a heterozygous nonsense variant in a gene whose function has been indirectly associated in_animal_models with_the_neuronal_migration defect affecting GnRH neurons_is responsible for the"}
{"text": " cell migration through its known functions in regulation of focal adhesion and actin cytoskeletal assembly dynamics, but its role in regulation of myosin II is not known. Myosin II dynamically assembles into minifilaments at the leading edge of migrating cells, and PKC-mediated phosphorylation in Ser 1916 in the non-helical tail", "synonym_substitution": "cell migration through its known functions in regulation of focal adhesiveness and actin cytoskeletal fabrication dynamics, but its role in regulation of myosin II is not know. Myosin II dynamically assembles into minifilaments at the leading boundary of migrating cells, and PKC - mediated phosphorylation in Ser 1916 in the non - helical fag end", "butter_fingers": " cepl migration through its known functions in rejulatioh of focxl adhesion and actin cytoskxletql aswembly dynamics, but itr role in regulatuon id myosin IM is not known. Lyosnn II dynamicalli assembles hnto minifilamangs at the leading edge of migrating cqlls, anc OKC-mediated phjsphpwylafpok in Ser 1916 in the non-helical tail", "random_deletion": "cell migration through its known functions in focal and actin assembly dynamics, but myosin is not known. II dynamically assembles minifilaments at the leading edge of cells, and PKC-mediated phosphorylation in Ser 1916 in the non-helical tail", "change_char_case": " cell migration through its knOwn functioNs in rEguLatIoN of fOcal Adhesion and actIN cytOskeletal assembly dynamIcs, buT iTS rolE In RegulAtion of MYoSIN II Is NoT knOwN. myOsin Ii dyNamicalLy assembleS inTo MinifilamentS At The leading EdgE of migrating CelLs, and PkC-MedIAted pHosPhoryLation IN Ser 1916 in The non-helIcAL tail", "whitespace_perturbation": " cell migration through it s known fu nctio nsinre gula tion  of focal adhe s ionand actin cytoskeletal  asse mb l y dy n am ics,but its ro l e  in  r eg ula ti o nof my osi n II is  not known . M yo sin II dynam i ca lly assemb les  into minifi lam ents a tthe leadi ngedgeof mig r atingcells, an dP KC-med i ated ph o s ph oryl ation in Ser 1916 in the non-helica l tail ", "underscore_trick": " cell_migration through_its known functions in_regulation of_focal_adhesion and_actin_cytoskeletal assembly dynamics,_but its role_in regulation of myosin_II is not_known._Myosin II dynamically assembles into minifilaments at the leading edge of migrating cells, and_PKC-mediated_phosphorylation in_Ser_1916_in the non-helical tail"}
{"text": " strains carry the permissive Xpr1-sxv allele, and there are other XPR1 receptors in various non-rodent mammalian species that are fully permissive despite considerable sequence variation in the receptor-determining regions. We examined permissive cells from four mammalian species (Mus dunni, human, m", "synonym_substitution": "strains carry the permissive Xpr1 - sxv allele, and there are other XPR1 receptor in diverse non - rodent mammalian species that are fully permissive despite considerable sequence magnetic declination in the receptor - determining region. We examine permissive cells from four mammalian coinage (Mus dunni, human, m", "butter_fingers": " stgains carry the permissiye Xpr1-sxv allele, and thxre are other XOR1 receptors in various non-rldwnt mqmmalian species that xre fully permissuve vespite consideregle seqmznce bwriaciin in the recektor-determinhng regions. We ebalined permissive cells from four maimalian soecies (Mus dungi, hlmwn, m", "random_deletion": "strains carry the permissive Xpr1-sxv allele, and other receptors in non-rodent mammalian species considerable variation in the regions. We examined cells from four mammalian species (Mus human, m", "change_char_case": " strains carry the permissive xpr1-sxv alleLe, and TheRe aRe OtheR XPR1 Receptors in varIOus nOn-rodent mammalian speciEs thaT aRE fulLY pErmisSive desPItE COnsIdErAblE sEQuEnce vAriAtion in The receptoR-deTeRmining regioNS. WE examined pErmIssive cells fRom Four maMmAliAN specIes (mus duNni, humAN, m", "whitespace_perturbation": " strains carry the permiss ive Xpr1-s xv al lel e,an d th ereare other XPR1 rece ptors in various non-r odent  m a mmal i an  spec ies tha t  a r e  fu ll yper mi s si ve de spi te cons iderable s equ en ce variation in  the recep tor -determining  re gions.  W e e x amine d p ermis sive c e lls fr om four m am m alians pecies( M us  dun ni, human, m", "underscore_trick": " strains_carry the_permissive Xpr1-sxv allele, and_there are_other_XPR1 receptors_in_various non-rodent mammalian_species that are_fully permissive despite considerable_sequence variation in_the_receptor-determining regions. We examined permissive cells from four mammalian species (Mus dunni, human, m"}
{"text": ", antagonism of rhesus BST-2 by Vpu involved an interaction of their cytoplasmic domains. Importantly, a Vpu mutant carrying two mutations in its transmembrane domain rendering it incompetent for interaction with human BST-2 was able to interact with human BST-2 carrying the rhesus BST-", "synonym_substitution": ", antagonism of rhesus BST-2 by Vpu involved an interaction of their cytoplasmic domains. Importantly, a Vpu mutant carrying two mutation in its transmembrane knowledge domain rendering it incompetent for interaction with human BST-2 was able to interact with human BST-2 carrying the rhesus BST-", "butter_fingers": ", anhagonism of rhesus BST-2 bn Vpu involved au interection kf their cytoplasmic domains. Importaitly, a Vpy mutant carrying two outations in its rranwnembrane domain rekberinf it nnrompetent for ikteraction fith human BST-2 wxs able to interact with human BST-2 cawrying yhf rhesus BST-", "random_deletion": ", antagonism of rhesus BST-2 by Vpu interaction their cytoplasmic Importantly, a Vpu its domain rendering it for interaction with BST-2 was able to interact with BST-2 carrying the rhesus BST-", "change_char_case": ", antagonism of rhesus BST-2 by VpU involved aN inteRacTioN oF theIr cyToplasmic domaiNS. ImpOrtantly, a Vpu mutant carrYing tWo MUtatIOnS in itS transmEMbRANe dOmAiN reNdERiNg it iNcoMpetent For interacTioN wIth human BST-2 wAS aBle to interAct With human BST-2 CarRying tHe RheSUs BST-", "whitespace_perturbation": ", antagonism of rhesus BST -2 by Vpuinvol ved  an  i nter acti on of their cy t opla smic domains. Importan tly,aV pu m u ta nt ca rryingt wo m uta ti on s i ni ts  tran sme mbranedomain ren der in g it incompe t en t for inte rac tion with hu man  BST-2  w asa ble t o i ntera ct wit h  human  BST-2 ca rr y ing th e  rhesus B ST -", "underscore_trick": ", antagonism_of rhesus_BST-2 by Vpu involved_an interaction_of_their cytoplasmic_domains._Importantly, a Vpu_mutant carrying two_mutations in its transmembrane_domain rendering it_incompetent_for interaction with human BST-2 was able to interact with human BST-2 carrying the_rhesus_BST-"}
{"text": " comparison of the findings on PCBs and neurodevelopment when they are published for all 10 studies. We reviewed the effects of mean exposure experienced by the general public, resulting primarily from normal die, and not from unusual circumstances of occupation, accident, or local contamination. We also reviewed selected studies of populations with high consumption of fish", "synonym_substitution": "comparison of the findings on PCBs and neurodevelopment when they are published for all 10 studies. We reviewed the effect of base exposure experienced by the general populace, resulting primarily from normal die, and not from unusual circumstance of occupation, accident, or local contamination. We also review selected studies of population with high consumption of pisces", "butter_fingers": " colparison of the findings on PCBs and neoridevelmpment when thdy are published for all 10 stndiew. We eeviewed the effects ow mean exiosure experitnced by the geneczl publle, reshptiny 'rimarily from kormal die, dnd not from uturucl circumstances of occupation, accidqnt, or kofal contaminatyon. Eq alao reviewed selected studies of polulatiois with high comsumption of fish", "random_deletion": "comparison of the findings on PCBs and they published for 10 studies. We exposure by the general resulting primarily from die, and not from unusual circumstances occupation, accident, or local contamination. We also reviewed selected studies of populations with consumption of fish", "change_char_case": " comparison of the findings on pCBs and neuRodevEloPmeNt When They Are published foR All 10 sTudies. We reviewed the effEcts oF mEAn exPOsUre exPeriencED bY THe gEnErAl pUbLIc, ResulTinG primarIly from norMal DiE, and not from uNUsUal circumsTanCes of occupatIon, AccideNt, Or lOCal coNtaMinatIon. We aLSo reviEwed selecTeD StudieS Of populATIoNs wiTh high consumption OF fISh", "whitespace_perturbation": " comparison of the finding s on PCBsand n eur ode ve lopm entwhen they arep ubli shed for all 10 studie s. We  r e view e dthe e ffectso fm e anex po sur ee xp erien ced  by the  general p ubl ic , resultingp ri marily fro m n ormal die, a ndnot fr om  un u sualcir cumst anceso f occu pation, a cc i dent,o r local c on tami nation. We also r e vi e wed selected s tudies  o f  p o p ula tio ns with hi gh  cons u mptiono ff i s h", "underscore_trick": " comparison_of the_findings on PCBs and_neurodevelopment when_they_are published_for_all 10 studies._We reviewed the_effects of mean exposure_experienced by the_general_public, resulting primarily from normal die, and not from unusual circumstances of occupation, accident,_or_local contamination._We_also_reviewed selected studies of populations_with high consumption of fish"}
{"text": " estimations of brain metabolites may lead to a clearer interpretation of results where voxels have both gray and white matter and may be applied to studies of clinical population. RESEARCH ACCOMPLISHMENTS NOMID STUDIES: CLINICAL: 1. We analyzed 5 year outcome data in 20 patients and 3", "synonym_substitution": "estimations of brain metabolites may lead to a clear interpretation of results where voxels get both grey and white matter and may be lend oneself to studies of clinical population. RESEARCH ACCOMPLISHMENTS NOMID STUDIES: CLINICAL: 1. We analyze 5 year outcome datum in 20 patients and 3", "butter_fingers": " eshimations of brain metabulites may lead to a cnearer interprdtation of results where voxxls yave voth gray and white magter and lay be applitd to studies of rminical populzbion. XEWEARCH ACCOMPLLSHMENTS NOKID STUDIES: CLHNKCCL: 1. We analyzed 5 year outcome data ig 20 patirnhs and 3", "random_deletion": "estimations of brain metabolites may lead to interpretation results where have both gray be to studies of population. RESEARCH ACCOMPLISHMENTS STUDIES: CLINICAL: 1. We analyzed 5 outcome data in 20 patients and 3", "change_char_case": " estimations of brain metabolItes may leaD to a cLeaRer InTerpRetaTion of results wHEre vOxels have both gray and whIte maTtER and MAy Be appLied to sTUdIES of ClInIcaL pOPuLatioN. REsEARCH AcCOMPLISHMeNTs NoMID STUDIES: CliNiCAL: 1. We analYzeD 5 year outcome DatA in 20 patIeNts ANd 3", "whitespace_perturbation": " estimations of brain meta bolites ma y lea d t o a  c lear er i nterpretationo f re sults where voxels hav e bot hg raya nd  whit e matte r  a n d  ma ybe  ap pl i ed  to s tud ies ofclinical p opu la tion. RESEAR C HACCOMPLISH MEN TS NOMID STU DIE S: CLI NI CAL :  1. W e a nalyz ed 5 y e ar out come data  i n  20 pa t ients a n d  3 ", "underscore_trick": " estimations_of brain_metabolites may lead to_a clearer_interpretation_of results_where_voxels have both_gray and white_matter and may be_applied to studies_of_clinical population. RESEARCH ACCOMPLISHMENTS NOMID STUDIES: CLINICAL: 1. We analyzed 5 year outcome data_in_20 patients_and_3"}
{"text": " was collected approximately every 8 weeks, at delivery, and 6 weeks postpartum. The children were systematically assessed for the presence of neurodevelopmental defects and other outcomes through age 7 years. Summary: CPP Specimens. In two studies using CPP specimens, we measured sodium concentration to assess desiccation. Pren", "synonym_substitution": "was collected approximately every 8 weeks, at delivery, and 6 weeks postpartum. The child were systematically tax for the presence of neurodevelopmental defects and other consequence through age 7 years. Summary: CPP Specimens. In two study using CPP specimens, we measure sodium concentration to assess dehydration. Pren", "butter_fingers": " wad collected approximateln every 8 weeks, aj eelivecy, and 6 weeks pustpartum. The children were dywtemaupcally assessed for tfe presenbe of neueodetelopmental deferfs and other kmtcomzs through age 7 iears. Summarf: CPP Specimenv. Kn two studies using CPP specimens, we measurrd sodium concenjratipg to assess desiccation. Pren", "random_deletion": "was collected approximately every 8 weeks, at 6 postpartum. The were systematically assessed defects other outcomes through 7 years. Summary: Specimens. In two studies using CPP we measured sodium concentration to assess desiccation. Pren", "change_char_case": " was collected approximately Every 8 weeks, At delIveRy, aNd 6 WeekS posTpartum. The chilDRen wEre systematically assesSed foR tHE preSEnCe of nEurodevELoPMEntAl DeFecTs ANd Other OutComes thRough age 7 yeArs. suMmary: CPP SpecIMeNs. In two stuDieS using CPP speCimEns, we mEaSurED sodiUm cOncenTratioN To asseSs desiccaTiON. Pren", "whitespace_perturbation": " was collected approximate ly every 8  week s,atde live ry,and 6 weeks po s tpar tum. The children were  syst em a tica l ly  asse ssed fo r  t h e  pr es en ceof ne urode vel opmenta l defectsand  o ther outcome s  t hrough age  7years. Summa ry:  CPP S pe cim e ns. I n t wo st udiesu sing C PP specim en s , we m e asureds o di um c oncentration to a s se s s desiccation.  Pren", "underscore_trick": " was_collected approximately_every 8 weeks, at_delivery, and_6_weeks postpartum._The_children were systematically_assessed for the_presence of neurodevelopmental defects_and other outcomes_through_age 7 years. Summary: CPP Specimens. In two studies using CPP specimens, we measured_sodium_concentration to_assess_desiccation._Pren"}
{"text": " induction, few biologically characterized infectious P-MLVs have been sequenced for comparative analysis. We analyzed the complete genomes of 16 naturally occurring infectious P-MLVs, 12 of which were typed for pathogenic potential. We sought to identify ERV progenitors, recombinational hotspots, and segments that are always replaced, never replaced", "synonym_substitution": "induction, few biologically characterized infectious P - MLVs have been sequenced for relative psychoanalysis. We analyze the complete genome of 16 naturally occurring infectious phosphorus - MLVs, 12 of which were typed for pathogenic electric potential. We sought to identify ERV progenitors, recombinational hot spot, and segments that are always substitute, never replaced", "butter_fingers": " infuction, few biologically characterized nbfectimus P-MMVs have been sequenced for comparatmve qnalywis. We analyzed the cooplete gejomes of 16 nauurally occurring infectious P-MMYs, 12 oy xhich were typec for pathmgenic potentidl. Wz sought to identify ERV progenitors, recombonwtional hotspojs, anc segjvnus that are always replaced, never replactd", "random_deletion": "induction, few biologically characterized infectious P-MLVs have for analysis. We the complete genomes P-MLVs, of which were for pathogenic potential. sought to identify ERV progenitors, recombinational and segments that are always replaced, never replaced", "change_char_case": " induction, few biologically cHaracterizEd infEctIouS P-mLVs Have Been sequenced fOR comParative analysis. We analYzed tHe COmplETe GenomEs of 16 natURaLLY ocCuRrIng InFEcTious p-MLvs, 12 of whiCh were typeD foR pAthogenic potENtIal. We soughT to Identify ERV pRogEnitorS, rEcoMBinatIonAl hotSpots, aND segmeNts that arE aLWays rePLaced, neVER rEplaCed", "whitespace_perturbation": " induction, few biological ly charact erize d i nfe ct ious  P-M LVs have beens eque nced for comparative a nalys is .  Wea na lyzed  the co m pl e t e g en om esof 16  natu ral ly occu rring infe cti ou s P-MLVs, 12 of  which wer e t yped for pat hog enic p ot ent i al. W e s ought  to id e ntifyERV proge ni t ors, r e combina t i on al h otspots, and segm e nt s  that are alwa ys rep la c ed , nev erreplaced", "underscore_trick": " induction,_few biologically_characterized infectious P-MLVs have_been sequenced_for_comparative analysis._We_analyzed the complete_genomes of 16_naturally occurring infectious P-MLVs,_12 of which_were_typed for pathogenic potential. We sought to identify ERV progenitors, recombinational hotspots, and segments_that_are always_replaced,_never_replaced"}
{"text": ". We thus continued the design and synthesis of approximately 220 novel nucleoside analogs containing a cyano moiety at the 4'-position of the ribose and identified 3'-C-cyano-2-amino-9-[(1S,3R,4S)-4'-hydroxy-3'- hydroxymethyl]-", "synonym_substitution": ". We thus continued the design and synthesis of approximately 220 fresh nucleoside analogue contain a cyano moiety at the 4'-position of the ribose and identified 3'-C - cyano-2 - amino-9-[(1S,3R,4S)-4'-hydroxy-3'- hydroxymethyl]-", "butter_fingers": ". We thus continued the desinn and synthesis of appcoximatsly 220 novdl nucleoside analogs contaiiing a cyqno moiety at the 4'-posigion of tje ribosw anv identified 3'-C-cyeho-2-amino-9-[(1S,3R,4S)-4'-hyddlxy-3'- kyvroxymethyl]-", "random_deletion": ". We thus continued the design and approximately novel nucleoside containing a cyano the and identified 3'-C-cyano-2-amino-9-[(1S,3R,4S)-4'-hydroxy-3'-", "change_char_case": ". We thus continued the design aNd synthesiS of apProXimAtEly 220 nOvel Nucleoside analOGs coNtaining a cyano moiety at The 4'-poSiTIon oF ThE riboSe and idENtIFIed 3'-c-cYaNo-2-aMiNO-9-[(1S,3r,4S)-4'-hydRoxY-3'- hydroxYmethyl]-", "whitespace_perturbation": ". We thus continued the de sign and s ynthe sis  of  a ppro xima tely 220 novel nucl eoside analogs contain ing a  c y anom oi ety a t the 4 ' -p o s iti on  o f t he ri boseand  identi fied 3'-C- cya no -2-amino-9-[ ( 1S ,3R,4S)-4' -hy droxy-3'- hy dro xymeth yl ]-", "underscore_trick": ". We_thus continued_the design and synthesis_of approximately_220_novel nucleoside_analogs_containing a cyano_moiety at the_4'-position of the ribose_and identified 3'-C-cyano-2-amino-9-[(1S,3R,4S)-4'-hydroxy-3'-_hydroxymethyl]-"}
{"text": ", smoking, and education, and child?s gender, breast feeding, and other factors. Other exposure: The relations between concentrations of plasma DDE and several serum androgens were examined in 137 North Carolina black male farmers. Most had farmed about 30 years and 27% reported having used DDT. We studied indices", "synonym_substitution": ", smoking, and education, and child?s gender, breast feeding, and early divisor. Other exposure: The relative between concentration of plasma DDE and several serum androgens were examine in 137 North Carolina bootleg male farmers. Most had farmed about 30 years and 27% reported having used DDT. We learn indices", "butter_fingers": ", smlking, and education, and ghild?s gender, brgawt feeving, ans other wactors. Other exposure: The rxlatuons vetween concentrations of plasmw DDE ane seteral serum androgens wevz exajlned nn 137 North Carolika black mane farmers. Mosd fab farmed about 30 years and 27% reported raving isfd DDT. We studyed pnqicea", "random_deletion": ", smoking, and education, and child?s gender, and factors. Other The relations between several androgens were examined 137 North Carolina male farmers. Most had farmed about years and 27% reported having used DDT. We studied indices", "change_char_case": ", smoking, and education, and chiLd?s gender, bReast FeeDinG, aNd otHer fActors. Other expOSure: the relations between conCentrAtIOns oF PlAsma DdE and seVErAL SerUm AnDroGeNS wEre exAmiNed in 137 NoRth CarolinA blAcK male farmers. mOsT had farmed AboUt 30 years and 27% rePorTed havInG usED DDT. WE stUdied IndiceS", "whitespace_perturbation": ", smoking, and education,and child? s gen der , b re astfeed ing, and other fact ors. Other exposure: T he re la t ions be tween  concen t ra t i ons  o fpla sm a  D DE an d s everalserum andr oge ns  were examin e din 137 Nor thCarolina bla ckmale f ar mer s . Mos t h ad fa rmed a b out 30  years an d2 7% rep o rted ha v i ng  use d DDT. We studied in d ices", "underscore_trick": ", smoking,_and education,_and child?s gender, breast_feeding, and_other_factors. Other_exposure:_The relations between_concentrations of plasma_DDE and several serum_androgens were examined_in_137 North Carolina black male farmers. Most had farmed about 30 years and 27%_reported_having used_DDT._We_studied indices"}
{"text": " 1987 or 1992, extrapolated the result to the time of service in Vietnam, and assigned each veteran to one of four exposure categories: Comparison and three Ranch Hand categories (Background, Low, High). Reviews and meta-analyses: We expressed the exposure levels from 10 studies of PCB and neurodevelopment in a uniform manner using", "synonym_substitution": "1987 or 1992, extrapolated the result to the time of service in Vietnam, and impute each veteran to one of four vulnerability categories: Comparison and three Ranch Hand categories (Background, Low, High). Reviews and meta - analysis: We expressed the exposure level from 10 study of PCB and neurodevelopment in a uniform manner using", "butter_fingers": " 1987 og 1992, extrapolated the resuut to the time of servmce in Bietnam, xnd assigned each veteran to obe of four exposure categorkes: Compagison and thrte Ranch Hand catxfories (Ncckgrkmnd, Lmx, High). Reviews snd meta-andlyses: We exprasreb the exposure levels from 10 studies jf PCB snf neurodevelopient yn a lnlform manner using", "random_deletion": "1987 or 1992, extrapolated the result to of in Vietnam, assigned each veteran categories: and three Ranch categories (Background, Low, Reviews and meta-analyses: We expressed the levels from 10 studies of PCB and neurodevelopment in a uniform manner using", "change_char_case": " 1987 or 1992, extrapolated the result to The time of sErvicE in vieTnAm, anD assIgned each veterAN to oNe of four exposure categoRies: COmPArisON aNd thrEe Ranch hAnD CAteGoRiEs (BAcKGrOund, LOw, HIgh). ReviEws and meta-AnaLySes: We expressED tHe exposure LevEls from 10 studiEs oF PCB anD nEurODevelOpmEnt in A unifoRM manneR using", "whitespace_perturbation": " 1987 or 1992, extrapolate d the resu lt to  th e t im e of  ser vice in Vietna m , an d assigned each vetera n toon e  off ou r exp osure c a te g o rie s:  C omp ar i so n and  th ree Ran ch Hand ca teg or ies (Backgro u nd , Low, Hig h).  Reviews and  me ta-ana ly ses :  We e xpr essed  the e x posure  levels f ro m  10 st u dies of P CB  and  neurodevelopment in a uniform mann er usi ng ", "underscore_trick": " 1987_or 1992,_extrapolated the result to_the time_of_service in_Vietnam,_and assigned each_veteran to one_of four exposure categories:_Comparison and three_Ranch_Hand categories (Background, Low, High). Reviews and meta-analyses: We expressed the exposure levels from_10_studies of_PCB_and_neurodevelopment in a uniform manner_using"}
{"text": " the load-and-fail compliance sensing regime by showing a requirement for this FA behavior in durotaxis, but not in chemotaxis in a boyden chamber assay or in random cell migration. This work resulted in 2 publications We have been examining polymorphisms in genes involved in the leptin signaling pathway to identify gene variants impacting", "synonym_substitution": "the load - and - fail compliance sensing regime by testify a necessity for this FA behavior in durotaxis, but not in chemotaxis in a boyden chamber assay or in random cell migration. This study resulted in 2 publications We have been examine polymorphism in genes involved in the leptin signaling pathway to name gene variants impacting", "butter_fingers": " thf load-and-fail compliance sensing regime by shoxing a dequiremdnt for this FA behavior in vuroraxis, but not in chemotaxis in a boyfen chamver essay or in random cell migratjln. Tkiw work resultec in 2 publhcations We haee bzen examining polymorphisms in genes involvrd in the leptin sigmwlinf pathway to identify gene varianta impacuing", "random_deletion": "the load-and-fail compliance sensing regime by showing for FA behavior durotaxis, but not chamber or in random migration. This work in 2 publications We have been polymorphisms in genes involved in the leptin signaling pathway to identify gene variants", "change_char_case": " the load-and-fail compliance sEnsing regiMe by sHowIng A rEquiRemeNt for this FA behAVior In durotaxis, but not in cheMotaxIs IN a boYDeN chamBer assaY Or IN RanDoM cEll MiGRaTion. THis Work resUlted in 2 pubLicAtIons We have beEN eXamining poLymOrphisms in geNes InvolvEd In tHE leptIn sIgnalIng patHWay to iDentify geNe VAriantS ImpactiNG", "whitespace_perturbation": " the load-and-fail complia nce sensin g reg ime  by  s howi ng a  requirement f o r th is FA behavior in duro taxis ,b ut n o tin ch emotaxi s  i n a b oy de n c ha m be r ass ayor in r andom cell  mi gr ation. Thisw or k resulted  in  2 publicati ons  We ha ve  be e n exa min ing p olymor p hismsin genesin v olvedi n the l e p ti n si gnaling pathway t o  i d entify gene va riants  i m pa c t ing ", "underscore_trick": " the_load-and-fail compliance_sensing regime by showing_a requirement_for_this FA_behavior_in durotaxis, but_not in chemotaxis_in a boyden chamber_assay or in_random_cell migration. This work resulted in 2 publications We have been examining polymorphisms in_genes_involved in_the_leptin_signaling pathway to identify gene_variants impacting"}
{"text": " test these for passive protective activity using transgenic P. berghei parasites. Results have been presented at the American Society for Tropical Medicine and Hygiene (10 talks and posters-Philadelphia, PA)(2011). Results have been presented at the European BioMalPar meeting in Germany (2011), the Japanese Society for Par", "synonym_substitution": "test these for passive protective activity using transgenic P. berghei parasites. result have been confront at the American Society for Tropical Medicine and Hygiene (10 talks and posters - Philadelphia, PA)(2011). Results have been present at the European BioMalPar meeting in Germany (2011), the Japanese Society for Par", "butter_fingers": " tedt these for passive prouective activity osung trensgenid P. bergfei parasites. Results have bxen presebted at the American Suciety fog Tropicao Mevicine and Hygieis (10 talks and llstexs-'hiladelphia, PA)(2011). Results hdve been presettdd at the European BioMalPar meeting yn Germsnj (2011), the Japanesg Socpeey fkg Kar", "random_deletion": "test these for passive protective activity using berghei Results have presented at the and (10 talks and PA)(2011). Results have presented at the European BioMalPar meeting Germany (2011), the Japanese Society for Par", "change_char_case": " test these for passive protecTive activiTy usiNg tRanSgEnic p. berGhei parasites. RESultS have been presented at thE AmerIcAN SocIEtY for TRopical mEdICIne AnD HYgiEnE (10 TaLks anD poSters-PhIladelphia, pA)(2011). REsUlts have been PReSented at thE EuRopean BioMalpar MeetinG iN GeRMany (2011), tHe JApaneSe SociETy for PAr", "whitespace_perturbation": " test these for passive pr otective a ctivi tyusi ng  tra nsge nic P. berghei para sites. Results have be en pr es e nted at  theAmerica n  S o c iet yfo r T ro p ic al Me dic ine and  Hygiene ( 10ta lks and post e rs -Philadelp hia , PA)(2011).  Re sultsha veb een p res ented  at th e  Europ ean BioMa lP a r meet i ng in G e r ma ny ( 2011), the Japane s eS ociety for Par ", "underscore_trick": " test_these for_passive protective activity using_transgenic P._berghei_parasites. Results_have_been presented at_the American Society_for Tropical Medicine and_Hygiene (10 talks_and_posters-Philadelphia, PA)(2011). Results have been presented at the European BioMalPar meeting in Germany (2011),_the_Japanese Society_for_Par"}
{"text": "-RL180M/S202G/M204V) and ADV-resistant HBV (HBVADV-RA181T/N236T). ETV effectively reduced the synthesis of HBVWTCe at 10 and 102 nM concentrations giving an IC50 value of 16 nM. However, as expected,", "synonym_substitution": "-RL180M / S202G / M204V) and ADV - resistant HBV (HBVADV - RA181T / N236 T). ETV effectively reduced the synthesis of HBVWTCe at 10 and 102 nM concentration render an IC50 value of 16 nM. However, as expected,", "butter_fingers": "-RL180M/D202G/M204V) and ADV-resistant HBY (HBVADV-RA181T/N236T). ETR effecvively deduced ghe synthesis of HBVWTCe at 10 abd 102 nN concentrations givine an IC50 vwlue of 16 nM. Iowever, as expecvsd,", "random_deletion": "-RL180M/S202G/M204V) and ADV-resistant HBV (HBVADV-RA181T/N236T). ETV effectively synthesis HBVWTCe at and 102 nM of nM. However, as", "change_char_case": "-RL180M/S202G/M204V) and ADV-resistant HBV (hBVADV-RA181T/N236t). ETV eFfeCtiVeLy reDuceD the synthesis oF hBVWtCe at 10 and 102 nM concentratioNs givInG An IC50 VAlUe of 16 nm. HoweveR, As EXPecTeD,", "whitespace_perturbation": "-RL180M/S202G/M204V) and A DV-resista nt HB V ( HBV AD V-RA 181T /N236T). ETV e f fect ively reduced the synt hesis  o f  HBV W TC e at10 and1 02 n M c on ce ntr at i on s giv ing  an IC5 0 value of  16  n M. However,a sexpected,", "underscore_trick": "-RL180M/S202G/M204V) and_ADV-resistant HBV_(HBVADV-RA181T/N236T). ETV effectively reduced_the synthesis_of_HBVWTCe at_10_and 102 nM_concentrations giving an_IC50 value of 16_nM. However, as_expected,"}
{"text": " backgrounds. The DCTD expects that using additional validated PD assays to simultaneously interrogate multiple molecular targets both within and across important signaling pathways in a single biopsy specimen and/or surrogate tissue will point to rational combinations of molecular targeted agents. Because many molecular targeted therapies are used in combination regimens with best available chemotherapy, there is", "synonym_substitution": "backgrounds. The DCTD expects that using additional validate PD assay to simultaneously interrogate multiple molecular targets both within and across important signaling pathways in a unmarried biopsy specimen and/or surrogate tissue will point to intellectual combinations of molecular targeted agents. Because many molecular targeted therapies are use in combination regimens with best available chemotherapy, there is", "butter_fingers": " bafkgrounds. The DCTD expecus that using addnrional validzted PD xssays to simultaneously intxrrotate nultiple molecular tareets both within qnd ecross important signaliky patgaays mn a single bioksy specimen and/or surrogade tnssue will point to rational combinaeions og lolecular targgted sdenta. Because many molecular targeted fherapits are used in comnination regimens with besh avwilable chemotheraoy, there is", "random_deletion": "backgrounds. The DCTD expects that using additional assays simultaneously interrogate molecular targets both pathways a single biopsy and/or surrogate tissue point to rational combinations of molecular agents. Because many molecular targeted therapies are used in combination regimens with best chemotherapy, there is", "change_char_case": " backgrounds. The DCTD expects That using aDditiOnaL vaLiDateD PD aSsays to simultaNEousLy interrogate multiple mOlecuLaR TargETs Both wIthin anD AcROSs iMpOrTanT sIGnAling PatHways in A single bioPsy SpEcimen and/or sURrOgate tissuE wiLl point to ratIonAl combInAtiONs of mOleCular TargetED agentS. Because mAnY MolecuLAr targeTED tHeraPies are used in combINaTIon regimens witH best aVaILaBLE chEmoTherapy, theRe Is", "whitespace_perturbation": " backgrounds. The DCTD exp ects thatusing  ad dit io nalvali dated PD assay s  tosimultaneously interro gatemu l tipl e  m olecu lar tar g et s bot hwi thi na nd  acro ssimporta nt signali ngpa thways in as in gle biopsy  sp ecimen and/o r s urroga te  ti s sue w ill  poin t to r a tional  combinat io n s of m o lecular t ar gete d agents. Because ma n y molecular ta rgeted  t h er a p ies  ar e used inco mbina t ion reg i me n s wit h  best availab le chemothe r apy , ther eis", "underscore_trick": " backgrounds._The DCTD_expects that using additional_validated PD_assays_to simultaneously_interrogate_multiple molecular targets_both within and_across important signaling pathways_in a single_biopsy_specimen and/or surrogate tissue will point to rational combinations of molecular targeted agents. Because_many_molecular targeted_therapies_are_used in combination regimens with_best available chemotherapy, there is"}
{"text": " this process to qualified vendors in order to accelerate the rate of PD assay development and validation and expand the capacity without any compromise in the quality of the process or the resulting assays. The SAIC-Frederick PD program already has demonstrated a high level of competence managing outside vendors and specifying similarly complex, specialized technical services,", "synonym_substitution": "this process to qualified vendors in order to accelerate the pace of PD try exploitation and validation and elaborate the capacitance without any compromise in the quality of the process or the result assays. The SAIC - Frederick PD program already has show a high level of competence oversee outside vendors and intend similarly complex, specialized technical service,", "butter_fingers": " thls process to qualified yendors in order to accxlerate the ratd of PD assay development anv vaoidatuon and expand the capxcity witjout any comkromise in the quemity of the pdlcesv or the resultlng assays. Dhe SAIC-Frederhcy 'D program already has demonstrated w high kegel of competegce kwnagjng outside vendors and specifying similagly complex, specislized technical services,", "random_deletion": "this process to qualified vendors in order the of PD development and validation any in the quality the process or resulting assays. The SAIC-Frederick PD program has demonstrated a high level of competence managing outside vendors and specifying similarly specialized technical services,", "change_char_case": " this process to qualified venDors in ordeR to acCelEraTe The rAte oF PD assay develoPMent And validation and expand The caPaCIty wIThOut anY comproMIsE IN thE qUaLitY oF ThE procEss Or the reSulting assAys. thE SAIC-FrederiCK Pd program alReaDy has demonstRatEd a higH lEveL Of comPetEnce mAnaginG OutsidE vendors aNd SPecifyINg similARLy CompLex, specialized tecHNiCAl services,", "whitespace_perturbation": " this process to qualified  vendors i n ord ertoac cele rate  the rate of P D  ass ay development and val idati on ande xp and t he capa c it y wit ho ut  an yc om promi sein thequality of  th eprocess or t h eresultingass ays. The SAI C-F rederi ck  PD progr amalrea dy has demons trated ahi g h leve l  of com p e te ncemanaging outsidev en d ors and specif ying s im i la r l y c omp lex, speci al izedt echnica l  s e r v ice s ,", "underscore_trick": " this_process to_qualified vendors in order_to accelerate_the_rate of_PD_assay development and_validation and expand_the capacity without any_compromise in the_quality_of the process or the resulting assays. The SAIC-Frederick PD program already has demonstrated_a_high level_of_competence_managing outside vendors and specifying_similarly complex, specialized technical services,"}
{"text": " the SI-NETs, differentiate from the ISCs. A majority of EC cells are found at higher positions within the crypts and the villi and would eventually be sloughed as they reach the villus tips. However a small proportion of EC cells can be found below +4 position where an active stem cell niche", "synonym_substitution": "the SI - NETs, differentiate from the ISCs. A majority of EC cells are found at higher positions within the crypt and the villus and would finally be sloughed as they reach the villus tips. However a little proportion of EC cells can be establish below +4 position where an active stem cell niche", "butter_fingers": " thf SI-NETs, differentiate fvom the ISCs. A mchority of EC cells afe found at higher positions wuthin the crypts and the viuli and wluld evebtuaooy be sloujged as bkey rswch chx villus tips. Hpwever a skall proportiot uf EC cells can be found below +4 posityon whete an active stei cekj nidhe", "random_deletion": "the SI-NETs, differentiate from the ISCs. A EC are found higher positions within and eventually be sloughed they reach the tips. However a small proportion of cells can be found below +4 position where an active stem cell niche", "change_char_case": " the SI-NETs, differentiate froM the ISCs. A mAjoriTy oF EC CeLls aRe foUnd at higher posITionS within the crypts and the Villi AnD WoulD EvEntuaLly be slOUgHED as ThEy ReaCh THe VilluS tiPs. HowevEr a small prOpoRtIon of EC cells CAn Be found belOw +4 pOsition where An aCtive sTeM ceLL nichE", "whitespace_perturbation": " the SI-NETs, differentiat e from the  ISCs . A  ma jo rity  ofEC cells are f o undat higher positions wi thinth e  cry p ts  andthe vil l ia n d w ou ld  ev en t ua lly b e s loughed  as they r eac hthe villus t i ps . Howevera s mall proport ion  of EC  c ell s  canbefound  below +4 pos ition whe re an act i ve stem c el l ni che", "underscore_trick": " the_SI-NETs, differentiate_from the ISCs. A_majority of_EC_cells are_found_at higher positions_within the crypts_and the villi and_would eventually be_sloughed_as they reach the villus tips. However a small proportion of EC cells can_be_found below_+4_position_where an active stem cell_niche"}
{"text": " antibodies in these children to antigens present on the surface of parasitized erythrocytes. We have investigated changes in these antibody populations with age, with malaria exposure, and with host genotype. Another aspect of our studies of host responses to proteins on the surface of parasitized erythrocytes, we have continued our collaboration with Dr. K", "synonym_substitution": "antibodies in these children to antigens present on the surface of parasitized erythrocytes. We have investigate change in these antibody populations with old age, with malaria photograph, and with host genotype. Another aspect of our study of host responses to protein on the open of parasitized erythrocytes, we have continue our collaboration with Dr. K", "butter_fingers": " anhibodies in these childrtn to antigens prgswnt on the shrface ow parasitized erythrocytes. Wx hace incestigated changes in ghese antpbody popylatmons with age, wivg malarlc expkdure, end with host ggnotype. Anotver aspect of muf dtudies of host responses to proteigs on tne surface of patasitpzqd edjtmrocytes, we have continued our ckllaboretion with Dr. K", "random_deletion": "antibodies in these children to antigens present surface parasitized erythrocytes. have investigated changes age, malaria exposure, and host genotype. Another of our studies of host responses proteins on the surface of parasitized erythrocytes, we have continued our collaboration with K", "change_char_case": " antibodies in these children To antigens PreseNt oN thE sUrfaCe of Parasitized eryTHrocYtes. We have investigated ChangEs IN theSE aNtiboDy populATiONS wiTh AgE, wiTh MAlAria eXpoSure, and With host geNotYpE. Another aspeCT oF our studieS of Host responseS to ProteiNs On tHE surfAce Of parAsitizED erythRocytes, we HaVE contiNUed our cOLLaBoraTion with Dr. K", "whitespace_perturbation": " antibodies in these child ren to ant igens  pr ese nt  onthesurface of par a siti zed erythrocytes. We h ave i nv e stig a te d cha nges in th e s e a nt ib ody  p o pu latio nswith ag e, with ma lar ia  exposure, a n dwith hostgen otype. Anoth eraspect  o f o u r stu die s ofhost r e sponse s to prot ei n s on t h e surfa c e  o f pa rasitized erythro c yt e s, we have con tinued  o u rc o lla bor ation with  D r. K", "underscore_trick": " antibodies_in these_children to antigens present_on the_surface_of parasitized_erythrocytes._We have investigated_changes in these_antibody populations with age,_with malaria exposure,_and_with host genotype. Another aspect of our studies of host responses to proteins on_the_surface of_parasitized_erythrocytes,_we have continued our collaboration_with Dr. K"}
{"text": " with HPIV3 and challenged 40 days later with HPIV3/EboGP, replication of the vector could not be detected, indicating a high level of restriction. Surprisingly, however, the immune response to EBOV GP was almost equivalent to that achieved in control animals that had not been previously infected with HPIV3", "synonym_substitution": "with HPIV3 and challenged 40 days later with HPIV3 / EboGP, replication of the vector could not be detect, indicate a high level of limitation. Surprisingly, however, the immune reply to EBOV GP was almost equivalent to that achieved in control condition animals that had not been previously infected with HPIV3", "butter_fingers": " wihh HPIV3 and challenged 40 aays later with HPIV3/EbmGP, rellicatiov of the vector could not be dwtecttb, indicating a high uevel of gestrictiin. Snrprisingly, howetsr, the limuns res'oise to EBOV GP eas almost equivalent to tfac achieved in control animals that hwd not nefn previously ynfebtqd wjnh HPIV3", "random_deletion": "with HPIV3 and challenged 40 days later replication the vector not be detected, restriction. however, the immune to EBOV GP almost equivalent to that achieved in animals that had not been previously infected with HPIV3", "change_char_case": " with HPIV3 and challenged 40 days Later with HpIV3/EbOGP, RepLiCatiOn of The vector could NOt be Detected, indicating a higH leveL oF RestRIcTion. SUrprisiNGlY, HOweVeR, tHe iMmUNe RespoNse To EBOV Gp was almost EquIvAlent to that aCHiEved in contRol Animals that hAd nOt been PrEviOUsly iNfeCted wIth HPIv3", "whitespace_perturbation": " with HPIV3 and challenged  40 days l aterwit h H PI V3/E boGP , replicationo f th e vector could not bedetec te d , in d ic ating  a high le v e l o fre str ic t io n. Su rpr isingly , however,  th eimmune respo n se  to EBOV G P w as almost eq uiv alentto  th a t ach iev ed in  contr o l anim als thatha d  not b e en prev i o us ly i nfected with HPIV 3 ", "underscore_trick": " with_HPIV3 and_challenged 40 days later_with HPIV3/EboGP,_replication_of the_vector_could not be_detected, indicating a_high level of restriction._Surprisingly, however, the_immune_response to EBOV GP was almost equivalent to that achieved in control animals that_had_not been_previously_infected_with HPIV3"}
{"text": " species of cDNA retained the self-primer. This indicates that integration of the Tf1 cDNA relies on mechanisms other than reverse transcription to remove the primer. [unreadable] [unreadable] Our analysis of the genome sequence of S. pombe revealed a strong clustering of pre-existing LTRs associated with the 5", "synonym_substitution": "species of cDNA retained the self - primer. This indicate that consolidation of the Tf1 cDNA relies on mechanism early than reverse transcription to remove the fuse. [ unreadable ] [ unreadable ] Our psychoanalysis of the genome succession of S. pombe revealed a strong bunch of pre - existing LTRs associated with the 5", "butter_fingers": " spfcies of cDNA retained tme self-primer. Thnw indirates tgat inteeration of the Tf1 cDNA relied in mexhanisms other than rexerse trajscriptiin ti remove thx primer. [unreaswble] [nnreadable] Our snalysis ox the genome saqjeuce of S. pombe revealed a strong cluftering ov pre-existing JTRs wssodpaued with the 5", "random_deletion": "species of cDNA retained the self-primer. This integration the Tf1 relies on mechanisms remove primer. [unreadable] [unreadable] analysis of the sequence of S. pombe revealed a clustering of pre-existing LTRs associated with the 5", "change_char_case": " species of cDNA retained the sElf-primer. THis inDicAteS tHat iNtegRation of the Tf1 cdnA reLies on mechanisms other tHan reVeRSe trANsCriptIon to reMOvE THe pRiMeR. [unReADaBle] [unReaDable] OuR analysis oF thE gEnome sequencE Of s. pombe reveAleD a strong clusTerIng of pRe-ExiSTing LtRs AssocIated wITh the 5", "whitespace_perturbation": " species of cDNA retainedthe self-p rimer . T his  i ndic ates  that integrat i on o f the Tf1 cDNA relieson me ch a nism s  o therthan re v er s e  tr an sc rip ti o nto re mov e the p rimer. [un rea da ble] [unread a bl e] Our ana lys is of the ge nom e sequ en ceo f S.pom be re vealed a stro ng cluste ri n g of p r e-exist i n gLTRs  associated witht he 5", "underscore_trick": " species_of cDNA_retained the self-primer. This_indicates that_integration_of the_Tf1_cDNA relies on_mechanisms other than_reverse transcription to remove_the primer. [unreadable]_[unreadable]_Our analysis of the genome sequence of S. pombe revealed a strong clustering of_pre-existing_LTRs associated_with_the_5"}
{"text": " Cas9 RNP complexes does not result in a significant, Cas9-specific mutational burden within recipient cells. This observation has relevance to current Cas9-based ex vivo genome-editing strategies. 2.2 Homology-independent targeted integration (HITI). We have utilized a novel NHEJ-", "synonym_substitution": "Cas9 RNP complexes does not result in a significant, Cas9 - specific mutational burden within recipient role cell. This observation has relevance to current Cas9 - free-base ex-wife vivo genome - editing strategies. 2.2 Homology - independent target integration (HITI). We have utilized a novel NHEJ-", "butter_fingers": " Cad9 RNP complexes does not result in a siybificait, Cas9-slecific outational burden within recmpiebt ceols. This observation hxs relevajce to cyrreit Cas9-based ex vmbo genome-editjkg stxavegies. 2.2 Homologi-independent targeted intecrxtnon (HITI). We have utilized a novel NHQJ-", "random_deletion": "Cas9 RNP complexes does not result in Cas9-specific burden within cells. This observation ex genome-editing strategies. 2.2 targeted integration (HITI). have utilized a novel NHEJ-", "change_char_case": " Cas9 RNP complexes does not resUlt in a signIficaNt, CAs9-sPeCifiC mutAtional burden wIThin Recipient cells. This obseRvatiOn HAs reLEvAnce tO currenT caS9-BAseD eX vIvo GeNOmE-editIng StrategIes. 2.2 HomologY-inDePendent targeTEd IntegratioN (HItI). We have utilIzeD a noveL NhEJ-", "whitespace_perturbation": " Cas9 RNP complexes does n ot resultin asig nif ic ant,  Cas 9-specific mut a tion al burden within recip ientce l ls.T hi s obs ervatio n  h a s  re le va nce  t o  c urren t C as9-bas ed ex vivo  ge no me-editing s t ra tegies. 2. 2 H omology-inde pen dent t ar get e d int egr ation  (HITI ) . We h ave utili ze d  a nov e l NHEJ- ", "underscore_trick": " Cas9_RNP complexes_does not result in_a significant,_Cas9-specific_mutational burden_within_recipient cells. This_observation has relevance_to current Cas9-based ex_vivo genome-editing strategies._2.2_Homology-independent targeted integration (HITI). We have utilized a novel NHEJ-"}
{"text": " the regulation of GnRH secretion and uterine or brain/skull development. We are also investigating the role of genetic variants in 55 genes known to cause IGD in a subgroup of individuals with functional hypothalamic amenorrhea (HA), a hormonally similar condition that occurs in association with risk factors such as nutritional deprivation", "synonym_substitution": "the regulation of GnRH secretion and uterine or brain / skull development. We are also investigate the function of genetic variants in 55 genes know to cause IGD in a subgroup of individuals with running hypothalamic amenorrhea (HA), a hormonally similar condition that occurs in affiliation with hazard factors such as nutritional deprivation", "butter_fingers": " thf regulation of GnRH secvetion and uteriuw or bcain/skuml develupment. We are also investigaving the eole of genetic variangs in 55 gejes knowb to xause IGD mh a subnxoup kn indnvmduals with fungtional hypmthalamic amenmrfhza (HA), a hormonally similar condition that ovckrs in associajion eyth dpsj factors such as nutritional deprivetion", "random_deletion": "the regulation of GnRH secretion and uterine development. are also the role of known cause IGD in subgroup of individuals functional hypothalamic amenorrhea (HA), a hormonally condition that occurs in association with risk factors such as nutritional deprivation", "change_char_case": " the regulation of GnRH secretIon and uterIne or BraIn/sKuLl deVeloPment. We are also INvesTigating the role of genetIc varIaNTs in 55 GEnEs knoWn to cauSE Igd In a SuBgRouP oF InDividUalS with fuNctional hyPotHaLamic amenorrHEa (hA), a hormonaLly Similar condiTioN that oCcUrs IN assoCiaTion wIth risK FactorS such as nuTrITional DEprivatION", "whitespace_perturbation": " the regulation of GnRH se cretion an d ute rin e o rbrai n/sk ull developmen t . We  are also investigatin g the  r o le o f  g eneti c varia n ts i n 5 5ge nes  k n ow n tocau se IGDin a subgr oup  o f individual s  w ith functi ona l hypothalam icamenor rh ea( HA),a h ormon ally s i milarcondition  t h at occ u rs in a s s oc iati on with risk fact o rs such as nutrit ionalde p ri v a tio n", "underscore_trick": " the_regulation of_GnRH secretion and uterine_or brain/skull_development._We are_also_investigating the role_of genetic variants_in 55 genes known_to cause IGD_in_a subgroup of individuals with functional hypothalamic amenorrhea (HA), a hormonally similar condition that_occurs_in association_with_risk_factors such as nutritional deprivation"}
{"text": "ameter flow cytometry. Compared to filarial-uninfected endemic normals (EN), microfilaria (mf) positive infected patients (Inf) had a reduced CD4 central memory (T(CM)) compartment. In addition, Inf patients tended to have more effector memory cells (T(EM)) and fewer effector", "synonym_substitution": "ameter flow cytometry. Compared to filarial - uninfected endemic normals (EN), microfilaria (mf) incontrovertible infect patients (Inf) had a reduced CD4 cardinal memory (T(CM) ) compartment. In addition, Inf patients tended to hold more effector memory cells (T(EM) ) and few effecter", "butter_fingers": "ameher flow cytometry. Compaved to filarial-uuunfectxd endejic normxls (EN), microfilaria (mf) positmve unfecuvd patients (Inf) had a reduced BD4 centrao meniry (T(CM)) compartmenb. In zfditnoi, Inf patients jended to haee more effectmr mzmory cells (T(EM)) and fewer effector", "random_deletion": "ameter flow cytometry. Compared to filarial-uninfected endemic microfilaria positive infected (Inf) had a compartment. addition, Inf patients to have more memory cells (T(EM)) and fewer effector", "change_char_case": "ameter flow cytometry. ComparEd to filariAl-uniNfeCteD eNdemIc noRmals (EN), microfiLAria (Mf) positive infected patiEnts (INf) HAd a rEDuCed CD4 Central MEmORY (T(Cm)) cOmParTmENt. in addItiOn, Inf paTients tendEd tO hAve more effecTOr Memory cellS (T(Em)) and fewer effEctOr", "whitespace_perturbation": "ameter flow cytometry. Com pared to f ilari al- uni nf ecte d en demic normals( EN),  microfilaria (mf) pos itive  i n fect e dpatie nts (In f )h a d a  r ed uce dC D4  cent ral  memory  (T(CM)) c omp ar tment. In ad d it ion, Inf p ati ents tendedtohave m or e e f fecto r m emory  cells (T(EM) ) and few er effect o r", "underscore_trick": "ameter flow_cytometry. Compared_to filarial-uninfected endemic normals_(EN), microfilaria_(mf)_positive infected_patients_(Inf) had a_reduced CD4 central_memory (T(CM)) compartment. In_addition, Inf patients_tended_to have more effector memory cells (T(EM)) and fewer effector"}
{"text": " had complete resolution of skin and bone lesions and a complete laboratory response. Similarities of the bone lesions in DIRA and patients with CRMO have spurred interest in the evaluation of the IL-1 pathway in patients with CRMO as well. ADULT ONSET STILL'S STUDIES We are", "synonym_substitution": "had complete resolution of skin and bone lesion and a accomplished laboratory response. Similarities of the bone wound in DIRA and patients with CRMO have spurred pastime in the evaluation of the IL-1 nerve pathway in patients with CRMO as well. ADULT ONSET STILL'S STUDIES We are", "butter_fingers": " haf complete resolution of skin and bone lesions and a completd laboratory response. Similacitiws of the bone lesions in DKRA and pwtients qith XRMO have spurred lutereab in chx evaluation of the IL-1 padhway in patiettr cith CRMO as well. ADULT ONSET STILL'S STUDIEX Ae are", "random_deletion": "had complete resolution of skin and bone a laboratory response. of the bone with have spurred interest the evaluation of IL-1 pathway in patients with CRMO well. ADULT ONSET STILL'S STUDIES We are", "change_char_case": " had complete resolution of skIn and bone lEsionS anD a cOmPletE labOratory responsE. simiLarities of the bone lesioNs in DiRa And pATiEnts wIth CRMO HAvE SPurReD iNteReST iN the eValUation oF the IL-1 pathWay In Patients with crMo as well. ADUlT OnSET STILL'S STuDIeS We arE", "whitespace_perturbation": " had complete resolution o f skin and  bone  le sio ns  and  a c omplete labora t oryresponse. Similarities  of t he bone le sions  in DIR A  a n d  pa ti en tswi t hCRMOhav e spurr ed interes t i nthe evaluati o nof the IL- 1 p athway in pa tie nts wi th  CR M O aswel l. AD ULT ON S ET STI LL'S STUD IE S  We ar e ", "underscore_trick": " had_complete resolution_of skin and bone_lesions and_a_complete laboratory_response._Similarities of the_bone lesions in_DIRA and patients with_CRMO have spurred_interest_in the evaluation of the IL-1 pathway in patients with CRMO as well. ADULT_ONSET_STILL'S STUDIES_We_are"}
{"text": " In a parallel study, we investigated the importance of cysteine positioning for functional dimerization of BST-2. BST-2 consists of an N-terminal cytoplasmic domain, a TM domain, an ectodomain, and C-terminal membrane anchor. The N-terminal half of the BST-2 ectodom", "synonym_substitution": "In a parallel study, we investigated the importance of cysteine positioning for functional dimerization of BST-2. BST-2 consist of an N - concluding cytoplasmic domain, a TM knowledge domain, an ectodomain, and speed of light - terminal membrane anchor. The N - terminal one-half of the BST-2 ectodom", "butter_fingers": " In a parallel study, we invtstigated the importance of cyateine pusitioning for functional dileeizatuon of BST-2. BST-2 consistr of an N-nerminal xytoklasmic domain, a VJ domaik, an sgtodokein, and C-terminsl membrana anchor. The N-defmnnal half of the BST-2 ectodom", "random_deletion": "In a parallel study, we investigated the cysteine for functional of BST-2. BST-2 domain, TM domain, an and C-terminal membrane The N-terminal half of the BST-2", "change_char_case": " In a parallel study, we investiGated the imPortaNce Of cYsTeinE posItioning for funCTionAl dimerization of BST-2. BST-2 ConsiStS Of an n-TeRminaL cytoplASmIC DomAiN, a tM dOmAIn, An ectOdoMain, and c-terminal mEmbRaNe anchor. The N-TErMinal half oF thE BST-2 ectodom", "whitespace_perturbation": " In a parallel study, we i nvestigate d the  im por ta nceof c ysteine positi o ning  for functional dimeri zatio no f BS T -2 . BST -2 cons i st s ofan  N -te rm i na l cyt opl asmic d omain, a T M d om ain, an ecto d om ain, and C -te rminal membr ane  ancho r.  Th e  N-te rmi nal h alf of the BS T-2 ectod om ", "underscore_trick": " In_a parallel_study, we investigated the_importance of_cysteine_positioning for_functional_dimerization of BST-2._BST-2 consists of_an N-terminal cytoplasmic domain,_a TM domain,_an_ectodomain, and C-terminal membrane anchor. The N-terminal half of the BST-2 ectodom"}
{"text": " recombinase cre in cells of various lineages to ask and answer relevant questions. Tissues or cells of interest include Langerhans cells, keratinocytes, thymic epithelial cells and intestinal epithelia. The latter tissue is of interest because EpCAM mutations have been causally linked to congential tufting", "synonym_substitution": "recombinase cre in cells of various lineages to ask and suffice relevant question. Tissues or cells of sake admit Langerhans cells, keratinocytes, thymic epithelial cells and intestinal epithelia. The latter tissue is of sake because EpCAM mutations have been causally linked to congential tufting", "butter_fingers": " refombinase cre in cells on various lineaggs to asn and znswer rdlevant questions. Tissues or cwlls if interest include Lavgerhans bells, kerqtinixytes, thymmd epithcjial gells end intestinal gpithelia. Tha latter tissua ks of interest because EpCAM mutationf have nefn causally ligked eo ckngential tufting", "random_deletion": "recombinase cre in cells of various lineages and relevant questions. or cells of thymic cells and intestinal The latter tissue of interest because EpCAM mutations have causally linked to congential tufting", "change_char_case": " recombinase cre in cells of vaRious lineaGes to Ask And AnSwer ReleVant questions. TISsueS or cells of interest inclUde LaNgERhanS CeLls, keRatinocYTeS, THymIc EpIthElIAl Cells And IntestiNal epithelIa. THe Latter tissue IS oF interest bEcaUse EpCAM mutaTioNs have BeEn cAUsallY liNked tO congeNTial tuFting", "whitespace_perturbation": " recombinase cre in cellsof various  line age s t oaskandanswer relevan t  que stions. Tissues or cel ls of  i n tere s tinclu de Lang e rh a n s c el ls , k er a ti nocyt es,  thymic  epithelia l c el ls and intes t in al epithel ia.  The lattertis sue is  o f i n teres t b ecaus e EpCA M  mutat ions have  b e en cau s ally li n k ed  tocongential tuftin g ", "underscore_trick": " recombinase_cre in_cells of various lineages_to ask_and_answer relevant_questions._Tissues or cells_of interest include_Langerhans cells, keratinocytes, thymic_epithelial cells and_intestinal_epithelia. The latter tissue is of interest because EpCAM mutations have been causally linked_to_congential tufting"}
{"text": " sensitivity to other clinical anesthetics. From this result we infer the existence of a component of the nervous system that is preferentially affected by this drug. The ryanodine receptor (Ryr) has been reported to be unusually sensitive to halothane in vitro but, to our knowledge, the importance of this component to", "synonym_substitution": "sensitivity to other clinical anesthetics. From this result we infer the being of a part of the nervous system that is preferentially involve by this drug. The ryanodine sense organ (Ryr) has been reported to be unusually sensitive to halothane in vitro but, to our knowledge, the importance of this part to", "butter_fingers": " sejsitivity to other clinigal anesthetics. Yeom thms resumt we inwer the existence of a compoient of tye nervous system that is prefegentially afftcted by this druj. The ryanodins reczpvor (Ryr) has beek reported do be unusuallf reusitive to halothane in vitro but, to our knpwpedge, the impottanct os thjs component to", "random_deletion": "sensitivity to other clinical anesthetics. From this infer existence of component of the affected this drug. The receptor (Ryr) has reported to be unusually sensitive to in vitro but, to our knowledge, the importance of this component to", "change_char_case": " sensitivity to other clinicaL anesthetiCs. FroM thIs rEsUlt wE infEr the existence OF a coMponent of the nervous sysTem thAt IS preFErEntiaLly affeCTeD BY thIs DrUg. THe RYaNodinE reCeptor (RYr) has been rEpoRtEd to be unusuaLLy Sensitive tO haLothane in vitRo bUt, to ouR kNowLEdge, tHe iMportAnce of THis comPonent to", "whitespace_perturbation": " sensitivity to other clin ical anest hetic s.Fro mthis  res ult we infer t h e ex istence of a component  of t he nerv o us  syst em that is p ref er en tia ll y  a ffect edby this  drug. The  ry an odine recept o r(Ryr) hasbee n reported t o b e unus ua lly sensi tiv e tohaloth a ne invitro but ,t o ourk nowledg e ,  t he i mportance of this co m ponent to", "underscore_trick": " sensitivity_to other_clinical anesthetics. From this_result we_infer_the existence_of_a component of_the nervous system_that is preferentially affected_by this drug._The_ryanodine receptor (Ryr) has been reported to be unusually sensitive to halothane in vitro_but,_to our_knowledge,_the_importance of this component to"}
{"text": " of an unwanted or excessive type of immune response to substances (antigens) in our environment and in autoimmune diseases. Because T cells respond to foreign substances (antigens) in the form of peptide-major histocompatibility complex (MHC) molecule pairs on cell surfaces, we wish to know how such complexes interact with", "synonym_substitution": "of an unwanted or excessive type of immune response to substances (antigen) in our environment and in autoimmune disease. Because thyroxine cells respond to extraneous substances (antigens) in the shape of peptide - major histocompatibility building complex (MHC) molecule pairs on cell surfaces, we wish to know how such building complex interact with", "butter_fingers": " of an unwanted or excessivt type of immune tewponse to sugstances (antigens) in our environment abd in autoimmune diseases. Bdcause T bells respond ro foreign substangzs (anflgens) mn the form of keptide-major histocompatibhlktv complex (MHC) molecule pairs on cell surfacrs, we wish to knjw hpr sudh complexes interact with", "random_deletion": "of an unwanted or excessive type of to (antigens) in environment and in respond foreign substances (antigens) the form of histocompatibility complex (MHC) molecule pairs on surfaces, we wish to know how such complexes interact with", "change_char_case": " of an unwanted or excessive tyPe of immune RespoNse To sUbStanCes (aNtigens) in our enVIronMent and in autoimmune disEases. beCAuse t CeLls reSpond to FOrEIGn sUbStAncEs (ANtIgens) In tHe form oF peptide-maJor HiStocompatibiLItY complex (MHc) moLecule pairs oN ceLl surfAcEs, wE Wish tO knOw how Such coMPlexes Interact wItH", "whitespace_perturbation": " of an unwanted or excessi ve type of  immu neres po nseto s ubstances (ant i gens ) in our environment a nd in  a u toim m un e dis eases.B ec a u seTce lls  r e sp ond t o f oreignsubstances  (a nt igens) in th e  f orm of pep tid e-major hist oco mpatib il ity compl ex(MHC)  molec u le pai rs on cel ls urface s , we wi s h  t o kn ow how such compl e xe s  interact with ", "underscore_trick": " of_an unwanted_or excessive type of_immune response_to_substances (antigens)_in_our environment and_in autoimmune diseases._Because T cells respond_to foreign substances_(antigens)_in the form of peptide-major histocompatibility complex (MHC) molecule pairs on cell surfaces, we_wish_to know_how_such_complexes interact with"}
{"text": " ADV and TDF and slightly more potent than 3TC and TAF, although that of CMCP was significantly less potent than that of ETV or CdG. Representative titration curves comprised of the data from three independent assays giving 50% inhibitory concentrations (IC50s) of 1.7, 0.5", "synonym_substitution": "ADV and TDF and slightly more potent than 3TC and TAF, although that of CMCP was significantly less potent than that of ETV or CdG. Representative titration curves comprised of the datum from three autonomous assay giving 50% inhibitory concentration (IC50s) of 1.7, 0.5", "butter_fingers": " ADG and TDF and slightly mure potent than 3TC and TAF, amthough ghat of CMCP was significantpy less potent than that of EGV or CdG. Represebtatmve titration cucbes comixised lf tke data from thrge independett assays givitg 50% nnhibitory concentrations (IC50s) of 1.7, 0.5", "random_deletion": "ADV and TDF and slightly more potent and although that CMCP was significantly ETV CdG. Representative titration comprised of the from three independent assays giving 50% concentrations (IC50s) of 1.7, 0.5", "change_char_case": " ADV and TDF and slightly more pOtent than 3Tc and TaF, aLthOuGh thAt of cMCP was signifiCAntlY less potent than that of EtV or CDG. rEpreSEnTativE titratIOn CURveS cOmPriSeD Of The daTa fRom threE independeNt aSsAys giving 50% inhIBiTory concenTraTions (IC50s) of 1.7, 0.5", "whitespace_perturbation": " ADV and TDF and slightlymore poten t tha n 3 TCan d TA F, a lthough that o f  CMC P was significantly le ss po te n t th a nthatof ETVo rC d G.Re pr ese nt a ti ve ti tra tion cu rves compr ise dof the dataf ro m three in dep endent assay s g iving50 % i n hibit ory  conc entrat i ons (I C50s) of1. 7 , 0.5", "underscore_trick": " ADV_and TDF_and slightly more potent_than 3TC_and_TAF, although_that_of CMCP was_significantly less potent_than that of ETV_or CdG. Representative_titration_curves comprised of the data from three independent assays giving 50% inhibitory concentrations (IC50s)_of_1.7, 0.5"}
{"text": " activity. Finally, we continued projects related to Vif and its interaction with the host restriction factor APOBEC3G, focusing in particular on the role of a recently identified host factor CBF. BST-2/Vpu: We found that the functional antagonism of rhesus macaque BST-", "synonym_substitution": "activity. Finally, we continued projects relate to Vif and its interaction with the server restriction factor APOBEC3 G, focusing in finical on the role of a recently identified horde factor CBF. BST-2 / Vpu: We found that the running hostility of rhesus macaque BST-", "butter_fingers": " achivity. Finally, we continmed projects relcred to Vif ahd its ivteraction with the host resvricrion dactor APOBEC3G, focusine in partpcular on the eole of a cscently identjnied kowt factor CBF. NST-2/Vpu: We fmund that the xuvccional antagonism of rhesus macaque FST-", "random_deletion": "activity. Finally, we continued projects related to its with the restriction factor APOBEC3G, role a recently identified factor CBF. BST-2/Vpu: found that the functional antagonism of macaque BST-", "change_char_case": " activity. Finally, we continueD projects rElateD to vif AnD its InteRaction with the HOst rEstriction factor APOBEC3g, focuSiNG in pARtIculaR on the rOLe OF A reCeNtLy iDeNTiFied hOst Factor CbF. BST-2/Vpu: We FouNd That the functIOnAl antagoniSm oF rhesus macaqUe BsT-", "whitespace_perturbation": " activity. Finally, we con tinued pro jects  re lat ed  toVifand its intera c tion  with the host restric tionfa c torA PO BEC3G , focus i ng i n p ar ti cul ar on  therol e of arecently i den ti fied host fa c to r CBF. BST -2/ Vpu: We foun d t hat th efun c tiona l a ntago nism o f  rhesu s macaque  B S T-", "underscore_trick": " activity._Finally, we_continued projects related to_Vif and_its_interaction with_the_host restriction factor_APOBEC3G, focusing in_particular on the role_of a recently_identified_host factor CBF. BST-2/Vpu: We found that the functional antagonism of rhesus macaque BST-"}
{"text": "LOC) over eating. Such data suggest the importance of leptin resistance as a factor stimulating weight gain and have led to recent explorations of other syndromes associated with obesity that may cause dysregulation of leptin signaling, including Bardet Biedl syndrome. Current studies are directed at understanding additional genetic, physiological, psychological, and metabolic", "synonym_substitution": "LOC) over eating. Such data suggest the importance of leptin resistance as a agent stimulate weight gain and have led to late explorations of other syndromes associate with obesity that may cause dysregulation of leptin signaling, include Bardet Biedl syndrome. Current studies are directed at understand additional genetic, physiologic, psychological, and metabolic", "butter_fingers": "LOC) over eating. Such data smggest the imporjabce of leptih resistxnce as a factor stimulating wwight gain and have led to fecent exilorationw of ither syndckmes associatsf wich obesity that kay cause gysregulation mf lzptin signaling, including Bardet Bieql syndtole. Current stuqies wre sprtcted at understanding additional genetib, physiological, pxychological, and metabolic", "random_deletion": "LOC) over eating. Such data suggest the leptin as a stimulating weight gain explorations other syndromes associated obesity that may dysregulation of leptin signaling, including Bardet syndrome. Current studies are directed at understanding additional genetic, physiological, psychological, and metabolic", "change_char_case": "LOC) over eating. Such data suggEst the impoRtancE of LepTiN resIstaNce as a factor stIMulaTing weight gain and have lEd to rEcENt exPLoRatioNs of othER sYNDroMeS aSsoCiATeD with ObeSity thaT may cause dYsrEgUlation of lepTIn Signaling, iNclUding Bardet BIedL syndrOmE. CuRRent sTudIes arE direcTEd at unDerstandiNg ADditioNAl genetIC, PhYsioLogical, psychologiCAl, ANd metabolic", "whitespace_perturbation": "LOC) over eating. Such dat a suggestthe i mpo rta nc e of  lep tin resistance as a  factor stimulating we ightga i n an d  h ave l ed to r e ce n t  ex pl or ati on s  o f oth ersyndrom es associa ted  w ith obesityt ha t may caus e d ysregulation  of  lepti nsig n aling , i nclud ing Ba r det Bi edl syndr om e . Curr e nt stud i e saredirected at under s ta n ding additiona l gene ti c ,p h ysi olo gical, psy ch ologi c al, and me t a b oli c ", "underscore_trick": "LOC) over_eating. Such_data suggest the importance_of leptin_resistance_as a_factor_stimulating weight gain_and have led_to recent explorations of_other syndromes associated_with_obesity that may cause dysregulation of leptin signaling, including Bardet Biedl syndrome. Current studies_are_directed at_understanding_additional_genetic, physiological, psychological, and metabolic"}
{"text": " average global surface area reduction was greater than in any one cortical region alone. The area that appeared preserved with age was the MTL, but this may have been due to limitations in our method. Future studies will be needed to assess brain histological changes that occur during normal aging as related to these morphometric measures. We will", "synonym_substitution": "average global surface area decrease was great than in any one cortical region alone. The sphere that appeared preserve with age was the MTL, but this may have been ascribable to limitations in our method. Future studies will be necessitate to assess brain histological change that occur during normal aging as related to these morphometric measures. We will", "butter_fingers": " avfrage global surface arex reduction was greatec than jn any ove cortical region alone. The aeea tyat appeared preserved with age was the MTL, vut this meg have nzen dhc to nmmitations in oor method. Fudure studies whlu ye needed to assess brain histologicwl chanbed that occur doring gormzl aging as related to these morphkmetric measures. We eill", "random_deletion": "average global surface area reduction was greater any cortical region The area that the but this may been due to in our method. Future studies will needed to assess brain histological changes that occur during normal aging as related these morphometric measures. We will", "change_char_case": " average global surface area rEduction waS greaTer ThaN iN any One cOrtical region aLOne. THe area that appeared presErved WiTH age WAs The MTl, but thiS MaY HAve BeEn Due To LImItatiOns In our meThod. Future StuDiEs will be needED tO assess braIn hIstological cHanGes thaT oCcuR DurinG noRmal aGing as RElated To these moRpHOmetriC MeasureS. wE wIll", "whitespace_perturbation": " average global surface ar ea reducti on wa s g rea te r th an i n any one cort i calregion alone. The area  that  a p pear e dprese rved wi t ha g e w as  t heMT L ,but t his  may ha ve been du e t olimitationsi nour method . F uture studie s w ill be  n eed e d toass ess b rain h i stolog ical chan ge s  thato ccur du r i ng  nor mal aging as rela t ed to these morph ometri cm ea s u res . W e will", "underscore_trick": " average_global surface_area reduction was greater_than in_any_one cortical_region_alone. The area_that appeared preserved_with age was the_MTL, but this_may_have been due to limitations in our method. Future studies will be needed to_assess_brain histological_changes_that_occur during normal aging as_related to these morphometric measures._We will"}
{"text": " most potent toxic substances known. Measurable amounts of TCDD are in virtually everyone in the United States. Of particular interest is that recent animal and human data suggest that TCDD interferes with glucose metabolism, even at background levels of exposure. The Collaborative Perinatal Project (CPP) was a", "synonym_substitution": "most potent toxic substances known. Measurable amounts of TCDD are in about everyone in the United States. Of especial interest is that recent animal and human datum suggest that TCDD intervene with glucose metabolism, even at background level of exposure. The Collaborative Perinatal Project (CPP) was a", "butter_fingers": " modt potent toxic substancts known. Measurable amouits of FCDD are in virtually everyone in thx Unuted Wtates. Of particular ivterest id that rwcenu animal and humai data smygest bhat CCVD interferes wlth glucose metabolism, evan ac background levels of exposure. The Sollabotahive Perinatal Prokqct (DIP) was a", "random_deletion": "most potent toxic substances known. Measurable amounts are virtually everyone the United States. recent and human data that TCDD interferes glucose metabolism, even at background levels exposure. The Collaborative Perinatal Project (CPP) was a", "change_char_case": " most potent toxic substances Known. MeasuRable AmoUntS oF TCDd are In virtually eveRYone In the United States. Of parTiculAr INterESt Is thaT recent ANiMAL anD hUmAn dAtA SuGgest ThaT TCDD inTerferes wiTh gLuCose metaboliSM, eVen at backgRouNd levels of exPosUre. The coLlaBOratiVe PErinaTal ProJEct (CPP) Was a", "whitespace_perturbation": " most potent toxic substan ces known.  Meas ura ble  a moun ts o f TCDD are inv irtu ally everyone in the U nited  S t ates .  O f par ticular in t e res tis  th at re centani mal and  human dat a s ug gest that TC D Dinterferes  wi th glucose m eta bolism ,eve n  at b ack groun d leve l s of e xposure.Th e  Colla b orative P er inat al Project (CPP)w as a", "underscore_trick": " most_potent toxic_substances known. Measurable amounts_of TCDD_are_in virtually_everyone_in the United_States. Of particular_interest is that recent_animal and human_data_suggest that TCDD interferes with glucose metabolism, even at background levels of exposure. The_Collaborative_Perinatal Project_(CPP)_was_a"}
{"text": " testing this new formalism. 4. The fourth project, in collaboration with Dr. Dave Lovinger?s Laboratory, investigates the interactions of the Stargazen protein with GluR1 ion channels. GluR1 has been shown to play a decisive role in synaptic efficacy, as activity causes GluR1 to migrate", "synonym_substitution": "testing this new formalism. 4. The fourth project, in collaboration with Dr. Dave Lovinger?s Laboratory, investigates the interaction of the Stargazen protein with GluR1 ion groove. GluR1 has been shown to play a decisive character in synaptic efficacy, as activity causes GluR1 to migrate", "butter_fingers": " tedting this new formalism. 4. The fourth project, ii collagoration with Dr. Dave Lovinger?s Labocatoey, incestigates the interacgions of nhe Stargqzen protein wivg GluR1 ljn cgwnnenw. GluR1 has beek shown to [lay a decisiva fope in synaptic efficacy, as activity causes GpuR1 to migrate", "random_deletion": "testing this new formalism. 4. The fourth collaboration Dr. Dave Laboratory, investigates the with ion channels. GluR1 been shown to a decisive role in synaptic efficacy, activity causes GluR1 to migrate", "change_char_case": " testing this new formalism. 4. ThE fourth proJect, iN coLlaBoRatiOn wiTh Dr. Dave LovingER?s LaBoratory, investigates thE inteRaCTionS Of The StArgazen PRoTEIn wItH GLuR1 IoN ChAnnelS. GlUR1 has beEn shown to pLay A dEcisive role iN SyNaptic effiCacY, as activity cAusEs GluR1 To MigRAte", "whitespace_perturbation": " testing this new formalis m. 4. Thefourt h p roj ec t, i n co llaboration wi t h Dr . Dave Lovinger?s Labo rator y, inve s ti gates  the in t er a c tio ns  o f t he St argaz enprotein  with GluR 1 i on  channels. G l uR 1 has been  sh own to playa d ecisiv erol e  in s yna pticeffica c y, asactivityca u ses Gl u R1 to m i g ra te", "underscore_trick": " testing_this new_formalism. 4. The fourth_project, in_collaboration_with Dr._Dave_Lovinger?s Laboratory, investigates_the interactions of_the Stargazen protein with_GluR1 ion channels._GluR1_has been shown to play a decisive role in synaptic efficacy, as activity causes_GluR1_to migrate"}
{"text": "OP, the specimen handling SOP to achieve valid assay results, and training courses offered at the NCI-F for laboratory staff from extramural institutions that wish to conduct a validated assay on site. To qualify to conduct their own assays, institutions are required to send laboratory staff for assay operator certification classes at NCI", "synonym_substitution": "OP, the specimen handling SOP to achieve valid assay results, and training courses volunteer at the NCI - F for lab staff from extramural institutions that wish to conduct a validated assay on web site. To qualify to conduct their own assays, mental hospital are required to send lab staff for assay operator certification course at NCI", "butter_fingers": "OP, hhe specimen handling SOK to achieve valib assay resulfs, and tfaining courses offered at tie NXI-F fir laboratory staff frum extramlral instututmons that wish to conducb a vzpidacev assay on site. To qualiff to conduct tvekr own assays, institutions are requirqd to srnf laboratory sjaff gjr aasay operator certification classea at NCP", "random_deletion": "OP, the specimen handling SOP to achieve results, training courses at the NCI-F institutions wish to conduct validated assay on To qualify to conduct their own institutions are required to send laboratory staff for assay operator certification classes at", "change_char_case": "OP, the specimen handling SOP tO achieve vaLid asSay ResUlTs, anD traIning courses ofFEred At the NCI-F for laboratory Staff FrOM extRAmUral iNstitutIOnS THat WiSh To cOnDUcT a valIdaTed assaY on site. To qUalIfY to conduct thEIr Own assays, iNstItutions are rEquIred to SeNd lABoratOry Staff For assAY operaTor certifIcATion clASses at Nci", "whitespace_perturbation": "OP, the specimen handlingSOP to ach ieveval idas sayresu lts, and train i ng c ourses offered at theNCI-F  f o r la b or atory  stafff ro m ext ra mu ral  i n st ituti ons  that w ish to con duc ta validateda ss ay on site . T o qualify to  co nductth eir own a ssa ys, i nstitu t ions a re requir ed to sen d  labora t o ry  sta ff for assay oper a to r  certification  class es at N CI", "underscore_trick": "OP, the_specimen handling_SOP to achieve valid_assay results,_and_training courses_offered_at the NCI-F_for laboratory staff_from extramural institutions that_wish to conduct_a_validated assay on site. To qualify to conduct their own assays, institutions are required_to_send laboratory_staff_for_assay operator certification classes at_NCI"}
{"text": " the osmotic properties. Combining these measurements allows us to determine the length scales governing the macroscopic thermodynamic properties. It is important to emphasize that this information cannot be obtained by other techniques. We have studied the effect of multivalent cations, particularly calcium ions, on the structure of various model systems mimicking soft tissues. Divalent", "synonym_substitution": "the osmotic properties. Combining these measurements allows us to settle the duration scales governing the macroscopic thermodynamic properties. It is crucial to emphasize that this information cannot be obtain by other techniques. We have analyze the effect of multivalent cation, particularly calcium ions, on the structure of various exemplar systems mimicking soft tissues. Divalent", "butter_fingers": " thf osmotic properties. Comnining these measuremenvs alloss us to determine the length scales givernung the macroscopic thdrmodynampc properries. Ut is impocfant to emphaalze tkav this informatlon cannot te obtained by oghzr techniques. We have studied the efsect of mkltivalent catyons, [artjbuoarly calcium ions, on the strhcture mf various mocel systems mimicking soft tisdues. Divalent", "random_deletion": "the osmotic properties. Combining these measurements allows determine length scales the macroscopic thermodynamic emphasize this information cannot obtained by other We have studied the effect of cations, particularly calcium ions, on the structure of various model systems mimicking soft Divalent", "change_char_case": " the osmotic properties. CombiNing these mEasurEmeNts AlLows Us to Determine the leNGth sCales governing the macroScopiC tHErmoDYnAmic pRopertiES. IT IS imPoRtAnt To EMpHasizE thAt this iNformation CanNoT be obtained bY OtHer techniqUes. we have studieD thE effecT oF muLTivalEnt CatioNs, partICularlY calcium iOnS, On the sTRucture OF VaRiouS model systems mimiCKiNG soft tissues. DiValent", "whitespace_perturbation": " the osmotic properties. C ombining t hesemea sur em ents  all ows us to dete r mine  the length scales gov ernin gt he m a cr oscop ic ther m od y n ami cpr ope rt i es . Itisimporta nt to emph asi ze  that this i n fo rmation ca nno t be obtaine d b y othe rtec h nique s.We ha ve stu d ied th e effectof multiv a lent ca t i on s, p articularly calci u mi ons, on the st ructur eo fv a rio usmodel syst em s mim i cking s o ft t i ssu e s. Divalent", "underscore_trick": " the_osmotic properties._Combining these measurements allows_us to_determine_the length_scales_governing the macroscopic_thermodynamic properties. It_is important to emphasize_that this information_cannot_be obtained by other techniques. We have studied the effect of multivalent cations, particularly_calcium_ions, on_the_structure_of various model systems mimicking_soft tissues. Divalent"}
{"text": " us to tune the morphology of DNA-based assemblies. In recent studies we have investigated the mechanism of fiber formation from small hydrogelator molecules in biological cells. Fluorescent imaging revealed that self-assembly directly affects the distribution of these small peptidic molecules in a cellular environment. Cell viability tests suggested that the states and the spatial", "synonym_substitution": "us to tune the morphology of DNA - based assemblies. In recent studies we have investigate the mechanism of roughage formation from small hydrogelator molecules in biological cell. Fluorescent imaging revealed that self - forum immediately affects the distribution of these small peptidic molecules in a cellular environment. Cell viability tests indicate that the states and the spatial", "butter_fingers": " us to tune the morphology uf DNA-based assgmvlies. Mn receht studids we have investigated the lexhaniwm of fiber formation wrom smalp hydrogwlatie molecules in biologicam celnw. Fluorescent lmaging revaaled that selx-arszmbly directly affects the distributyon of yhfse small peptydic ioledllts in a cellular environment. Cell viabilpty tests suggestrd that the states and the spahial", "random_deletion": "us to tune the morphology of DNA-based recent we have the mechanism of molecules biological cells. Fluorescent revealed that self-assembly affects the distribution of these small molecules in a cellular environment. Cell viability tests suggested that the states and spatial", "change_char_case": " us to tune the morphology of DNa-based asseMblieS. In RecEnT stuDies We have investigATed tHe mechanism of fiber formAtion FrOM smaLL hYdrogElator mOLeCULes In BiOloGiCAl Cells. fluOrescenT imaging reVeaLeD that self-assEMbLy directly AffEcts the distrIbuTion of ThEse SMall pEptIdic mOleculES in a ceLlular envIrONment. CELl viabiLITy TestS suggested that the STaTEs and the spatiaL", "whitespace_perturbation": " us to tune the morphology  of DNA-ba sed a sse mbl ie s. I n re cent studies w e  hav e investigated the mec hanis mo f fi b er  form ation f r om s mal lhy dro ge l at or mo lec ules in  biologica l c el ls. Fluoresc e nt  imaging r eve aled that se lf- assemb ly  di r ectly  af fects  the d i stribu tion of t he s e smal l  peptid i c  m olec ules in a cellula r  e n vironment. Cel l viab il i ty t est s s uggested t ha t the statesa nd t h e s p atial", "underscore_trick": " us_to tune_the morphology of DNA-based_assemblies. In_recent_studies we_have_investigated the mechanism_of fiber formation_from small hydrogelator molecules_in biological cells._Fluorescent_imaging revealed that self-assembly directly affects the distribution of these small peptidic molecules in_a_cellular environment._Cell_viability_tests suggested that the states_and the spatial"}
{"text": " experimental design included a parallel set of control treatments applied to samples of the same bulk HSPC population. HSPC samples were either i) mock electroporated, ii) electroporated in the absence of effector molecules, iii) electroporated with recombinant Cas9 alone, or iv) electropor", "synonym_substitution": "experimental design included a parallel set of control treatment enforce to samples of the like bulk HSPC population. HSPC sample distribution were either i) mock electroporated, ii) electroporated in the absence of effecter molecules, iii) electroporated with recombinant Cas9 entirely, or iv) electropor", "butter_fingers": " exoerimental design includtd a parallel set of convrol trsatments applied to samples of the seme vulk YSPC population. HSPC sxmples wege either i) mixk electro'krated, ln) eledbropoxaved in the absekce of effewtor molecules, iki) electroporated with recombinant Caf9 alone, og iv) electropot", "random_deletion": "experimental design included a parallel set of applied samples of same bulk HSPC i) electroporated, ii) electroporated the absence of molecules, iii) electroporated with recombinant Cas9 or iv) electropor", "change_char_case": " experimental design includeD a parallel Set of ConTroL tReatMentS applied to sampLEs of The same bulk HSPC populatIon. HSpC SAmplES wEre eiTher i) moCK eLECtrOpOrAteD, iI) ElEctroPorAted in tHe absence oF efFeCtor moleculeS, IiI) electropoRatEd with recombInaNt Cas9 aLoNe, oR Iv) eleCtrOpor", "whitespace_perturbation": " experimental design inclu ded a para llelset  of  c ontr ol t reatments appl i ed t o samples of the samebulkHS P C po p ul ation . HSPCs am p l eswe re  ei th e ri) mo ckelectro porated, i i)el ectroporated in  the absen ceof effectormol ecules ,iii )  elec tro porat ed wit h  recom binant Ca s9 alone, or iv)e l ec trop or", "underscore_trick": " experimental_design included_a parallel set of_control treatments_applied_to samples_of_the same bulk_HSPC population. HSPC_samples were either i)_mock electroporated, ii)_electroporated_in the absence of effector molecules, iii) electroporated with recombinant Cas9 alone, or iv)_electropor"}
{"text": " using FV for the gene therapy of LAD-1. A pre-IND type B meeting was held with members of the Center for Biologics Evaluation and Research (CBER) within the FDA. Regulatory review and accrual are currently on hold due to delays in production of GMP grade FV.", "synonym_substitution": "using FV for the gene therapy of LAD-1. A pre - IND type B meeting was reserve with extremity of the Center for Biologics Evaluation and Research (CBER) within the FDA. Regulatory review and accrual are currently on appreciation due to delays in production of GMP degree FV.", "butter_fingers": " uslng FV for the gene therxpy of LAD-1. A prg-IBD typx B meefing was held with members of the Ceiter for Viologics Evaluation avd Researbh (CBER) wuthii the FDA. Regulavkry revlzw ans accxuel are currentli on hold dua to delays in pfobuction of GMP grade FV.", "random_deletion": "using FV for the gene therapy of pre-IND B meeting held with members Evaluation Research (CBER) within FDA. Regulatory review accrual are currently on hold due delays in production of GMP grade FV.", "change_char_case": " using FV for the gene therapy oF LAD-1. A pre-INd type b meEtiNg Was hEld wIth members of thE centEr for Biologics EvaluatiOn and reSEarcH (cBeR) witHin the Fda. REGUlaToRy RevIeW AnD accrUal Are currEntly on holD duE tO delays in proDUcTion of GMP gRadE FV.", "whitespace_perturbation": " using FV for the gene the rapy of LA D-1.A p re- IN D ty pe B  meeting was h e ld w ith members of the Cen ter f or Biol o gi cs Ev aluatio n  a n d  Re se ar ch(C B ER ) wit hin  the FD A. Regulat ory  r eview and ac c ru al are cur ren tly on holddue  to de la ysi n pro duc tionof GMP gradeFV.", "underscore_trick": " using_FV for_the gene therapy of_LAD-1. A_pre-IND_type B_meeting_was held with_members of the_Center for Biologics Evaluation_and Research (CBER)_within_the FDA. Regulatory review and accrual are currently on hold due to delays in_production_of GMP_grade_FV."}
{"text": " enteropathy, a rare congenital diarrheal syndrome. Experiments that have been completed to date clearly indicate that the targeted EpCAM allele efficiently recombines in several lineages and that this results in phenotypes in several tissues. We are characterizing these phenotypes and are carrying out complementary in vitro studies to gain additional insights into mechanistic aspects of", "synonym_substitution": "enteropathy, a rare congenital diarrheal syndrome. Experiments that have been completed to date clearly indicate that the target EpCAM allele efficiently recombine in several lineages and that this result in phenotype in several tissues. We are characterizing these phenotype and are carry out complementary in vitro study to gain additional insight into mechanistic aspects of", "butter_fingers": " enheropathy, a rare congeniual diarrheal synbeome. Eeperimehts that have been completed to date coearlt indicate that the tafgeted EpBAM allelw efhiciently recombmhes in severam linzajes and that thls results hn phenotypes hn szveral tissues. We are characterizing these lhfnotypes and ate cagrring out complementary in vitro studiea to gapn additional insoghts into mechanistic aspfcts of", "random_deletion": "enteropathy, a rare congenital diarrheal syndrome. Experiments been to date indicate that the in lineages and that results in phenotypes several tissues. We are characterizing these and are carrying out complementary in vitro studies to gain additional insights into aspects of", "change_char_case": " enteropathy, a rare congenitaL diarrheal SyndrOme. expErImenTs thAt have been compLEted To date clearly indicate tHat thE tARgetED EPCAM aLlele efFIcIENtlY rEcOmbInES iN seveRal LineageS and that thIs rEsUlts in phenotYPeS in several TisSues. We are chaRacTeriziNg TheSE phenOtyPes anD are caRRying oUt complemEnTAry in vITro studIES tO gaiN additional insighTS iNTo mechanistic aSpects Of", "whitespace_perturbation": " enteropathy, a rare conge nital diar rheal  sy ndr om e. E xper iments that ha v e be en completed to date c learl yi ndic a te  that  the ta r ge t e d E pC AM  al le l eeffic ien tly rec ombines in  se ve ral lineages an d that thi s r esults in ph eno typesin  se v eraltis sues.  We ar e  chara cterizing  t h ese ph e notypes a nd  are  carrying out com p le m entary in vitr o stud ie s  t o gai n a dditionalin sight s  into m e ch a n i sti c  aspects of", "underscore_trick": " enteropathy,_a rare_congenital diarrheal syndrome. Experiments_that have_been_completed to_date_clearly indicate that_the targeted EpCAM_allele efficiently recombines in_several lineages and_that_this results in phenotypes in several tissues. We are characterizing these phenotypes and are_carrying_out complementary_in_vitro_studies to gain additional insights_into mechanistic aspects of"}
{"text": "asitology (2012), a World Health Organization workshop in Geneva, Switzerland (2012), and at Gennova, India. More than a decade ago, we reported that among dendritic cells, EpCAM was selectively expressed by epidermal Langerhans cells. In the past few years, we have revisited the utility", "synonym_substitution": "asitology (2012), a World Health Organization workshop in Geneva, Switzerland (2012), and at Gennova, India. More than a decade ago, we reported that among dendritic cells, EpCAM was selectively expressed by cuticular Langerhans cell. In the past few years, we have revisited the utility program", "butter_fingers": "asihology (2012), a World Health Ovganization workshop in Genevz, Switzefland (2012), and at Gennova, India. Loee thqn a decade ago, we repurted than among dwndrmtic cells, EpCAM was selcetivemn expxewsed by epiderkal Langervans cells. In dhd 'ast few years, we have revisited the utilitu", "random_deletion": "asitology (2012), a World Health Organization workshop Switzerland and at India. More than that dendritic cells, EpCAM selectively expressed by Langerhans cells. In the past few we have revisited the utility", "change_char_case": "asitology (2012), a World Health OrgaNization woRkshoP in genEvA, SwiTzerLand (2012), and at GennoVA, IndIa. More than a decade ago, we ReporTeD That AMoNg denDritic cELlS, ePCAm wAs SelEcTIvEly exPreSsed by ePidermal LaNgeRhAns cells. In thE PaSt few years, We hAve revisited The UtilitY", "whitespace_perturbation": "asitology (2012), a WorldHealth Org aniza tio n w or ksho p in  Geneva, Switz e rlan d (2012), and at Genno va, I nd i a. M o re  than  a deca d ea g o,we  r epo rt e dthatamo ng dend ritic cell s,Ep CAM was sele c ti vely expre sse d by epiderm alLanger ha nsc ells.  In  thepast f e w year s, we hav er evisit e d the u t i li ty", "underscore_trick": "asitology (2012),_a World_Health Organization workshop in_Geneva, Switzerland_(2012),_and at_Gennova,_India. More than_a decade ago,_we reported that among_dendritic cells, EpCAM_was_selectively expressed by epidermal Langerhans cells. In the past few years, we have revisited_the_utility"}
{"text": " formal process that has yielded past assay successes along with active project management will free up the SAIC-Frederic staff to focus on the development of much needed assays in areas of multi-channel analysis of drug response in rare tumor stem cells, new assays to distinguish cells recovering from chemotherapy damage or committing to cell death via apoptosis", "synonym_substitution": "formal process that has yielded past assay success along with active undertaking management will free up the SAIC - Frederic staff to focus on the growth of a lot needed assays in areas of multi - channel analysis of drug reaction in rare tumor stem cells, fresh assays to distinguish cell recovering from chemotherapy damage or commit to cell end via apoptosis", "butter_fingers": " fogmal process that has yitlded past assay successxs alonf with aztive project management wilp dree yp the SAIC-Frederic stxff to fobus on thw detelopment of muci needed assaya in crxas of multi-chaknel analyshs of drug res[ovsz in rare tumor stem cells, new assayf to dixtlnguish cells tecovtrigg fdom chemotherapy damage or committjng to bell death via appptosis", "random_deletion": "formal process that has yielded past assay with project management free up the the of much needed in areas of analysis of drug response in rare stem cells, new assays to distinguish cells recovering from chemotherapy damage or committing cell death via apoptosis", "change_char_case": " formal process that has yieldEd past assaY succEssEs aLoNg wiTh acTive project manAGemeNt will free up the SAIC-FreDeric StAFf to FOcUs on tHe develOPmENT of MuCh NeeDeD AsSays iN arEas of muLti-channel AnaLySis of drug resPOnSe in rare tuMor Stem cells, new AssAys to dIsTinGUish cEllS recoVering FRom cheMotherapy DaMAge or cOMmittinG TO cEll dEath via apoptosis", "whitespace_perturbation": " formal process that has y ielded pas t ass aysuc ce sses  alo ng with active proj ect management will fr ee up  t h e SA I C- Frede ric sta f ft o  fo cu sonth e  d evelo pme nt of m uch needed  as sa ys in areaso fmulti-chan nel  analysis of  dr ug res po nse in ra retumor  stemc ells,new assay st o dist i nguishc e ll s re covering from che m ot h erapy damage o r comm it t in g tocel l death vi aapopt o sis", "underscore_trick": " formal_process that_has yielded past assay_successes along_with_active project_management_will free up_the SAIC-Frederic staff_to focus on the_development of much_needed_assays in areas of multi-channel analysis of drug response in rare tumor stem cells,_new_assays to_distinguish_cells_recovering from chemotherapy damage or_committing to cell death via_apoptosis"}
{"text": " Objective 2: Develop and evaluate safety of CRISPR/Cas9-based strategies for permanent site-specific delivery of a therapeutic gene in human HSPCs. 2.1 Evaluate off-target Cas9 activity in human HSPCs We performed CRISPR-Cas9-based genome editing in human HSPCs and assessed the acquisition of", "synonym_substitution": "Objective 2: Develop and evaluate safety of CRISPR / Cas9 - based scheme for permanent web site - specific delivery of a therapeutic gene in human HSPCs. 2.1 measure off - target Cas9 activeness in human HSPCs We performed CRISPR - Cas9 - based genome editing in human HSPCs and measure the acquisition of", "butter_fingers": " Obuective 2: Develop and evauuate safety of CRISPR/Ras9-bases strateeies for permanent site-specihic eelivtgy of a therapeutic gdne in hulan HSPCw. 2.1 Etaluate off-targev Cas9 acbnvity ln huken HSPCs We pernormed CRIS[R-Cas9-based genmmd zditing in human HSPCs and assessed ehe acqiidition of", "random_deletion": "Objective 2: Develop and evaluate safety of for site-specific delivery a therapeutic gene off-target activity in human We performed CRISPR-Cas9-based editing in human HSPCs and assessed acquisition of", "change_char_case": " Objective 2: Develop and evaluaTe safety of cRISPr/CaS9-baSeD strAtegIes for permanenT Site-Specific delivery of a theRapeuTiC Gene IN hUman HsPCs. 2.1 EvaLUaTE Off-TaRgEt CAs9 ACtIvity In hUman HSPcs We perforMed cRiSPR-Cas9-based GEnOme editing In hUman HSPCs and AssEssed tHe AcqUIsitiOn oF", "whitespace_perturbation": " Objective 2: Develop andevaluate s afety  of  CR IS PR/C as9- based strategi e s fo r permanent site-speci fic d el i very of  a th erapeut i cg e nein  h uma nH SP Cs. 2 .1Evaluat e off-targ etCa s9 activityi nhuman HSPC s W e performedCRI SPR-Ca s9 -ba s ed ge nom e edi ting i n  human  HSPCs an da ssesse d  the ac q u is itio n of", "underscore_trick": " Objective_2: Develop_and evaluate safety of_CRISPR/Cas9-based strategies_for_permanent site-specific_delivery_of a therapeutic_gene in human_HSPCs. 2.1 Evaluate off-target_Cas9 activity in_human_HSPCs We performed CRISPR-Cas9-based genome editing in human HSPCs and assessed the acquisition of"}
{"text": " vaccine purposes. Despite the high level of attenuation, which would be predictive of a high level of vaccine safety, expressed foreign proteins were moderately-to-highly immunogenic. For example, AGM that were immunized IN and IT with two doses of NDV expressing the SARS S protein developed a high titer of SARS", "synonym_substitution": "vaccine purposes. Despite the high level of attenuation, which would be predictive of a high degree of vaccine condom, expressed foreign proteins were reasonably - to - highly immunogenic. For example, AGM that were immunized IN and IT with two doses of NDV express the SARS S protein developed a high titer of SARS", "butter_fingers": " vafcine purposes. Despite tme high level of attenuetion, wgich wouud be predictive of a high lxvel of vqccine safety, expressea foreign proteinw wece moderately-to-hmfhly immunogehlc. Fox xxample, AGM thaj were immunhzed IN and IT wktk two doses of NDV expressing the SAWS S prptfin developed w hibr tifvr of SARS", "random_deletion": "vaccine purposes. Despite the high level of would predictive of high level of were immunogenic. For example, that were immunized and IT with two doses of expressing the SARS S protein developed a high titer of SARS", "change_char_case": " vaccine purposes. Despite the High level oF atteNuaTioN, wHich WoulD be predictive oF A higH level of vaccine safety, eXpresSeD ForeIGn ProteIns were MOdERAteLy-To-HigHlY ImMunogEniC. For exaMple, AGM thaT weRe Immunized IN aND It with two doSes Of NDV expressIng The SARs S ProTEin deVelOped a High tiTEr of SArS", "whitespace_perturbation": " vaccine purposes. Despite  the highlevel  of  at te nuat ion,  which would b e  pre dictive of a high leve l ofva c cine sa fety,  expres s ed f ore ig npro te i ns  were  mo deratel y-to-highl y i mm unogenic. Fo r  e xample, AG M t hat were imm uni zed IN  a ndI T wit h t wo do ses of NDV ex pressingth e  SARSS  protei n de velo ped a high titero fS ARS", "underscore_trick": " vaccine_purposes. Despite_the high level of_attenuation, which_would_be predictive_of_a high level_of vaccine safety,_expressed foreign proteins were_moderately-to-highly immunogenic. For_example,_AGM that were immunized IN and IT with two doses of NDV expressing the_SARS_S protein_developed_a_high titer of SARS"}
{"text": " oncology breakthroughs into targeted therapeutics, and subsequently for translating these new drugs into patients by confirming that they work as intended in early clinical trials (Phase 0, I and II). The vision and pioneering effort of DCTD to develop, clinically implement and transfer to the oncology research community highly reproducible and informative PD assays", "synonym_substitution": "oncology breakthroughs into targeted therapeutics, and subsequently for translating these newfangled drug into patients by confirming that they make as intend in early clinical trials (Phase 0, I and II). The vision and pioneer effort of DCTD to develop, clinically enforce and transfer to the oncology research residential district highly reproducible and informative PD assays", "butter_fingers": " onfology breakthroughs intu targeted thercpeuticv, and aubsequevtly for translating these nxw deugs unto patients by confifming than they woek aw intended mh early clinidwl txiels (Phase 0, I anc II). The vhsion and pionaefiug effort of DCTD to develop, clinicajly impkelent and transser uo ehe kncology research community highly reprodlcible and informstive PD assays", "random_deletion": "oncology breakthroughs into targeted therapeutics, and subsequently these drugs into by confirming that early trials (Phase 0, and II). The and pioneering effort of DCTD to clinically implement and transfer to the oncology research community highly reproducible and informative assays", "change_char_case": " oncology breakthroughs into Targeted thErapeUtiCs, aNd SubsEqueNtly for translaTIng tHese new drugs into patienTs by cOnFIrmiNG tHat thEy work aS InTENdeD iN eArlY cLInIcal tRiaLs (Phase 0, i and II). The vIsiOn And pioneerinG EfFort of DCTD To dEvelop, clinicAllY impleMeNt aND tranSfeR to thE oncolOGy reseArch commuNiTY highlY ReproduCIBlE and Informative PD assaYS", "whitespace_perturbation": " oncology breakthroughs in to targete d the rap eut ic s, a nd s ubsequently fo r  tra nslating these new dru gs in to pati e nt s byconfirm i ng t hat  t he y w or k  a s int end ed in e arly clini cal  t rials (Phase 0,  I and II) . T he vision an d p ioneer in g e f fortofDCTDto dev e lop, c linically  i m plemen t  and tr a n sf er t o the oncology re s ea r ch community h ighlyre p ro d u cib leand inform at ive P D  assays ", "underscore_trick": " oncology_breakthroughs into_targeted therapeutics, and subsequently_for translating_these_new drugs_into_patients by confirming_that they work_as intended in early_clinical trials (Phase_0,_I and II). The vision and pioneering effort of DCTD to develop, clinically implement_and_transfer to_the_oncology_research community highly reproducible and_informative PD assays"}
{"text": " training effects on cognitive function and cognitively demanding everyday activities. The Phase II followup will consist of one assessment to include the Phase I post-test battery and a clinical assessment. The ACTIVE cohort (n = 2832) is a special sample, containing substantial oversampling of African American, socioeconomically poor,", "synonym_substitution": "training effects on cognitive function and cognitively demanding casual bodily process. The Phase II followup will consist of one appraisal to admit the Phase I post - test battery and a clinical assessment. The ACTIVE cohort (n = 2832) is a extra sample, containing significant oversampling of African American, socioeconomically poor,", "butter_fingers": " trwining effects on cognitlve function and cognitmvely dsmanding everyday activities. The Phade II fillowup will consist ow one assvssment ti inrlude the Phase M post-test batfcry aud a clinical asxessment. Tve ACTIVE cohost (n = 2832) is a special sample, containing stbstantoap oversampling of Ssriczn American, socioeconomically poor,", "random_deletion": "training effects on cognitive function and cognitively activities. Phase II will consist of Phase post-test battery and clinical assessment. The cohort (n = 2832) is a sample, containing substantial oversampling of African American, socioeconomically poor,", "change_char_case": " training effects on cognitivE function aNd cogNitIveLy DemaNdinG everyday activITies. the Phase II followup will ConsiSt OF one ASsEssmeNt to incLUdE THe PHaSe i poSt-TEsT battEry And a cliNical assesSmeNt. the ACTIVE cohORt (N = 2832) is a speciaL saMple, containiNg sUbstanTiAl oVErsamPliNg of AFrican aMericaN, socioecoNoMIcally POor,", "whitespace_perturbation": " training effects on cogni tive funct ion a ndcog ni tive ly d emanding every d ay a ctivities. The Phase I I fol lo w up w i ll  cons ist ofo ne a sse ss me ntto in clude  th e Phase  I post-te stba ttery and ac li nical asse ssm ent. The ACT IVE  cohor t(n=  2832 ) i s a s pecial sample , contain in g  subst a ntial o v e rs ampl ing of African Am e ri c an, socioecono micall yp oo r , ", "underscore_trick": " training_effects on_cognitive function and cognitively_demanding everyday_activities._The Phase_II_followup will consist_of one assessment_to include the Phase_I post-test battery_and_a clinical assessment. The ACTIVE cohort (n = 2832) is a special sample, containing_substantial_oversampling of_African_American,_socioeconomically poor,"}
{"text": " enumeration of and molecular changes in circulating tumor cells. These validated assays are achieved using a number of clinically useful technology platforms of the SAIC-Frederick PS program: immunoassay, quantitative RT-PCR, quantitative immunofluorescence of tumor sections and cytospins, and the Veridex Cell Search instrument a clinically validated platform", "synonym_substitution": "enumeration of and molecular changes in circulating tumor cells. These validate assay are achieved using a number of clinically utilitarian technology platforms of the SAIC - Frederick PS program: immunoassay, quantitative RT - PCR, quantitative immunofluorescence of tumor section and cytospins, and the Veridex Cell Search instrument a clinically validated chopine", "butter_fingers": " enkmeration of and moleculxr changes in cneculatmng tumkr cells. These validated assays are echiwved ysing a number of clinkcally usvful techbolojy platforms of vge SAIC-Nxederjgk PS 'rogram: immunoaxsay, quanthtative RT-PCR, xuxncitative immunofluorescence of tumor sectioms and cytospins, and ehe Bvrldex Cell Search instrument a cljnicallj validated platfprm", "random_deletion": "enumeration of and molecular changes in circulating These assays are using a number of SAIC-Frederick PS program: quantitative RT-PCR, quantitative of tumor sections and cytospins, and Veridex Cell Search instrument a clinically validated platform", "change_char_case": " enumeration of and molecular Changes in cIrculAtiNg tUmOr ceLls. THese validated aSSays Are achieved using a numbeR of clInICallY UsEful tEchnoloGY pLATfoRmS oF thE SaiC-fredeRicK PS progRam: immunoaSsaY, qUantitative Rt-pCr, quantitatIve ImmunofluoreSceNce of tUmOr sECtionS anD cytoSpins, aND the VeRidex Cell seARch insTRument a CLInIcalLy validated platfoRM", "whitespace_perturbation": " enumeration of and molecu lar change s incir cul at ingtumo r cells. These vali dated assays are achie ved u si n g an um ber o f clini c al l y  us ef ul  te ch n ol ogy p lat forms o f the SAIC -Fr ed erick PS pro g ra m: immunoa ssa y, quantitat ive  RT-PC R,  qu a ntita tiv e imm unoflu o rescen ce of tum or sectio n s and c y t os pins , and the Veridex Ce l l Search instr umentac li n i cal lyvalidatedpl atfor m ", "underscore_trick": " enumeration_of and_molecular changes in circulating_tumor cells._These_validated assays_are_achieved using a_number of clinically_useful technology platforms of_the SAIC-Frederick PS_program:_immunoassay, quantitative RT-PCR, quantitative immunofluorescence of tumor sections and cytospins, and the Veridex Cell_Search_instrument a_clinically_validated_platform"}
{"text": " acute and chronic diseases such as asthma and arthritis and infectious diseases including AIDS and TB. Our understanding of this feedback controlled signaling system in health and disease will enable us to understand viral pathogenesis and help us develop novel therapeutic interventions. HIV-1, HIV-2, and SIV Nef alleles are known to downmodulate", "synonym_substitution": "acute and chronic diseases such as asthma and arthritis and infectious diseases including AIDS and TB. Our reason of this feedback operate signaling system in health and disease will enable us to understand viral pathogenesis and serve us develop novel curative interventions. HIV-1, HIV-2, and SIV Nef alleles are known to downmodulate", "butter_fingers": " ackte and chronic diseases such as asthma and arvhritis and infdctious diseases including AMDS qnd TV. Our understanding of this feefback cobtroooed signalmhg systci in mealtk end disease wilk enable uv to understang xixal pathogenesis and help us develop novel yhfrapeutic intetventpogs. HJN-1, MIV-2, and SIV Nef alleles are knowh to doxnmodulate", "random_deletion": "acute and chronic diseases such as asthma and diseases including and TB. Our signaling in health and will enable us understand viral pathogenesis and help us novel therapeutic interventions. HIV-1, HIV-2, and SIV Nef alleles are known to downmodulate", "change_char_case": " acute and chronic diseases suCh as asthma And arThrItiS aNd inFectIous diseases inCLudiNg AIDS and TB. Our understaNding Of THis fEEdBack cOntrollED sIGNalInG sYstEm IN hEalth And Disease Will enable Us tO uNderstand virAL pAthogenesiS anD help us develOp nOvel thErApeUTic inTerVentiOns. HIV-1, hiV-2, and SiV Nef alleLeS Are knoWN to downMODuLate", "whitespace_perturbation": " acute and chronic disease s such asasthm a a ndar thri tisand infectious dise ases including AIDS an d TB.  O u r un d er stand ing oft hi s fee db ac k c on t ro lledsig nalingsystem inhea lt h and diseas e  w ill enable  us  to understa ndviralpa tho g enesi s a nd he lp usd evelop  novel th er a peutic interve n t io ns.HIV-1, HIV-2, and SI V  Nef alleles a re kno wn to d own mod ulate", "underscore_trick": " acute_and chronic_diseases such as asthma_and arthritis_and_infectious diseases_including_AIDS and TB._Our understanding of_this feedback controlled signaling_system in health_and_disease will enable us to understand viral pathogenesis and help us develop novel therapeutic_interventions._HIV-1, HIV-2,_and_SIV_Nef alleles are known to_downmodulate"}
{"text": " IL-1 receptor antagonist syndrome, DIRA, the crucial role for IL-1 in the pathophysiology of these illnesses with multiorgan involvement has been demonstrated. 2. A novel founder mutation in 2 Brazil patients with DIRA has been identified and may raise the awareness of that disease in Brazil. 3. S", "synonym_substitution": "IL-1 receptor antagonist syndrome, DIRA, the crucial role for IL-1 in the pathophysiology of these illness with multiorgan affair has been demonstrated. 2. A novel laminitis mutation in 2 Brazil affected role with DIRA has been identified and may raise the awareness of that disease in Brazil. 3. randomness", "butter_fingers": " IL-1 receptor antagonist synarome, DIRA, the eeucial role ror IL-1 iv the pathophysiology of thede illntfses with multiorgxn involvvment has beei demonstrated. 2. E novel njundsv mutctmon in 2 Brazil katients witv DIRA has beet kdzntified and may raise the awareness of thay fisease in Braeil. 3. X", "random_deletion": "IL-1 receptor antagonist syndrome, DIRA, the crucial IL-1 the pathophysiology these illnesses with 2. novel founder mutation 2 Brazil patients DIRA has been identified and may the awareness of that disease in Brazil. 3. S", "change_char_case": " IL-1 receptor antagonist syndrOme, DIRA, the CruciAl rOle FoR IL-1 iN the PathophysiologY Of thEse illnesses with multioRgan iNvOLvemENt Has beEn demonSTrATEd. 2. A NoVeL foUnDEr MutatIon In 2 BraziL patients wIth dIrA has been ideNTiFied and may RaiSe the awareneSs oF that dIsEasE In BraZil. 3. s", "whitespace_perturbation": " IL-1 receptor antagonistsyndrome,DIRA,  th e c ru cial  rol e for IL-1 int he p athophysiology of thes e ill ne s sesw it h mul tiorgan in v o lve me nt  ha sb ee n dem ons trated.  2. A nove l f ou nder mutatio n  i n 2 Brazil  pa tients withDIR A hasbe eni denti fie d and  may r a ise th e awarene ss of tha t  diseas e in  Bra zil. 3. S", "underscore_trick": " IL-1_receptor antagonist_syndrome, DIRA, the crucial_role for_IL-1_in the_pathophysiology_of these illnesses_with multiorgan involvement_has been demonstrated. 2._A novel founder_mutation_in 2 Brazil patients with DIRA has been identified and may raise the awareness_of_that disease_in_Brazil._3. S"}
{"text": " mouse leukemia viruses (E-, X-, P-MLVs) exist in mice as infectious viruses and as ERVs. All 3 MLV subgroups are linked to leukemogenesis, which involves generation of recombinants with polytropic host range. Although P-MLVs are deemed to be the proximal agents of disease", "synonym_substitution": "mouse leukemia viruses (E-, X-, P - MLVs) exist in mice as infectious virus and as ERVs. All 3 MLV subgroup are linked to leukemogenesis, which involves generation of recombinant with polytropic host range. Although P - MLVs are deem to be the proximal agent of disease", "butter_fingers": " mokse leukemia viruses (E-, X-, P-MLVs) exist in mice av infedtious vkruses and as ERVs. All 3 MLV duvgroukf are linked to lejkemogenedis, whicy intolves generatioi of recombinahbs wich polytropic hoxt range. Anthough P-MLVs drd beemed to be the proximal agents of qisease", "random_deletion": "mouse leukemia viruses (E-, X-, P-MLVs) exist as viruses and ERVs. All 3 leukemogenesis, involves generation of with polytropic host Although P-MLVs are deemed to be proximal agents of disease", "change_char_case": " mouse leukemia viruses (E-, X-, P-MLvs) exist in mIce as InfEctIoUs viRuseS and as ERVs. All 3 Mlv subGroups are linked to leukeMogenEsIS, whiCH iNvolvEs generATiON Of rEcOmBinAnTS wIth poLytRopic hoSt range. AltHouGh p-MLVs are deemED tO be the proxImaL agents of disEasE", "whitespace_perturbation": " mouse leukemia viruses (E -, X-, P-M LVs)exi stin  mic e as  infectious vi r uses  and as ERVs. All 3 ML V sub gr o upsa re  link ed to l e uk e m oge ne si s,wh i ch  invo lve s gener ation of r eco mb inants withp ol ytropic ho strange. Altho ugh  P-MLV sare deeme d t o bethe pr o ximalagents of  d i sease", "underscore_trick": " mouse_leukemia viruses_(E-, X-, P-MLVs) exist_in mice_as_infectious viruses_and_as ERVs. All_3 MLV subgroups_are linked to leukemogenesis,_which involves generation_of_recombinants with polytropic host range. Although P-MLVs are deemed to be the proximal agents_of_disease"}
{"text": "standing data has shown that antibodies can play a significant role in protection against erythrocytic stages of infection, we have pursued a detailed characterization of the antibody populations present in the Malian children. We have already shown that children with HbAS genotype show lower responses by ELISA to a number of merozoite antigens relative to", "synonym_substitution": "standing data has shown that antibodies can toy a meaning role in protection against erythrocytic stage of contagion, we have pursued a detailed characterization of the antibody populations present in the Malian child. We have already shown that children with HbAS genotype prove lower responses by ELISA to a issue of merozoite antigens relative to", "butter_fingers": "stajding data has shown thau antibodies can klqy a smgnificznt role in protection against erythcocyric sucges of infection, we have purdued a dwtaiowd charactxdizatiok of fme anciuody populationx present hn the Malian whklbren. We have already shown that chilqren wiyh HbAS genotype shoe lowsg vesponses by ELISA to a number or merozmite antigens relative to", "random_deletion": "standing data has shown that antibodies can significant in protection erythrocytic stages of detailed of the antibody present in the children. We have already shown that with HbAS genotype show lower responses by ELISA to a number of merozoite relative to", "change_char_case": "standing data has shown that aNtibodies cAn plaY a sIgnIfIcanT rolE in protection aGAinsT erythrocytic stages of iNfectIoN, We haVE pUrsueD a detaiLEd CHAraCtErIzaTiON oF the aNtiBody popUlations prEseNt In the Malian cHIlDren. We have AlrEady shown thaT chIldren WiTh HBaS genOtyPe shoW lower REsponsEs by ELISA To A Number OF merozoITE aNtigEns relative to", "whitespace_perturbation": "standing data has shown th at antibod ies c anpla ya si gnif icant role inp rote ction against erythroc yticst a geso finfec tion, w e  h a v e p ur su edad et ailed  ch aracter ization of  th eantibody pop u la tions pres ent  in the Mali anchildr en . W e  have  al ready  shown that c hildren w it h  HbASg enotype s ho w lo wer responses byE LI S A to a numberof mer oz o it e ant ige ns relativ eto", "underscore_trick": "standing data_has shown_that antibodies can play_a significant_role_in protection_against_erythrocytic stages of_infection, we have_pursued a detailed characterization_of the antibody_populations_present in the Malian children. We have already shown that children with HbAS genotype_show_lower responses_by_ELISA_to a number of merozoite_antigens relative to"}
{"text": " published this year. Project 3: Analysis of traction stress variation across single focal adhesions. Sergey V. Plotnikov, Benedikt Sabass, Clare M. Waterman The ability of eukaryotic cells to sense mechanical properties of the extracellular matrix (ECM) and to exhibit durotaxis (directed migration toward st", "synonym_substitution": "published this year. Project 3: Analysis of grip tension pas seul across single focal adhesiveness. Sergey V. Plotnikov, Benedikt Sabass, Clare M. Waterman The ability of eukaryotic cell to sense mechanical properties of the extracellular matrix (ECM) and to expose durotaxis (directed migration toward st", "butter_fingers": " puhlished this year. Projecu 3: Analysis of trcxtion vtress variatiun across single focal adhesmons. Sergtj V. Plotnikov, Benedikg Sabass, Blare M. Wqternqn The ability of cbkarykbic czlos to sense meghanical prmperties of tha dxcracellular matrix (ECM) and to exhibie durotsxls (directed midratpog tosard st", "random_deletion": "published this year. Project 3: Analysis of variation single focal Sergey V. Plotnikov, The of eukaryotic cells sense mechanical properties the extracellular matrix (ECM) and to durotaxis (directed migration toward st", "change_char_case": " published this year. Project 3: ANalysis of tRactiOn sTreSs VariAtioN across single fOCal aDhesions. Sergey V. PlotnikOv, BenEdIKt SaBAsS, ClarE M. WaterMAn tHE abIlItY of EuKArYotic CelLs to senSe mechanicAl pRoPerties of the EXtRacellular MatRix (ECM) and to eXhiBit durOtAxiS (DirecTed MigraTion toWArd st", "whitespace_perturbation": " published this year. Proj ect 3: Ana lysis  of  tr ac tion  str ess variationa cros s single focal adhesio ns. S er g ey V .  P lotni kov, Be n ed i k t S ab as s,Cl a re  M. W ate rman Th e abilityofeu karyotic cel l sto sense m ech anical prope rti es ofth e e x trace llu lar m atrix( ECM) a nd to exh ib i t duro t axis (d i r ec tedmigration towards t", "underscore_trick": " published_this year._Project 3: Analysis of_traction stress_variation_across single_focal_adhesions. Sergey V._Plotnikov, Benedikt Sabass,_Clare M. Waterman The_ability of eukaryotic_cells_to sense mechanical properties of the extracellular matrix (ECM) and to exhibit durotaxis (directed_migration_toward st"}
{"text": " 8-10% of host chromosomal DNA. Retroviruses were first recognized as naturally occurring infectious agents linked to various neoplasms in their host species. We have been engaged in an ongoing effort to characterize pathogenic viruses, and identify the various host factors that restrict the replication cycle of these viruses. Mouse leukemia viruses (MLVs)", "synonym_substitution": "8 - 10% of host chromosomal DNA. Retroviruses were first recognized as naturally occur infectious agent linked to various neoplasms in their master of ceremonies species. We have been engaged in an ongoing attempt to characterize pathogenic virus, and identify the various server factors that restrict the echo cycle of these viruses. Mouse leukemia viruses (MLVs )", "butter_fingers": " 8-10% ov host chromosomal DNA. Rttroviruses were yurst rxcognizsd as nagurally occurring infectious atents linked to various neoolasms in their hist wpecies. We izve beek engzned iu en ongoing effott to characderize pathogetiz riruses, and identify the various hose factots that restrict the wepljbauion cycle of these viruses. Mouse leukempa viruses (MLVs)", "random_deletion": "8-10% of host chromosomal DNA. Retroviruses were as occurring infectious linked to various We been engaged in ongoing effort to pathogenic viruses, and identify the various factors that restrict the replication cycle of these viruses. Mouse leukemia viruses (MLVs)", "change_char_case": " 8-10% of host chromosomal DNA. RetroViruses werE firsT reCogNiZed aS natUrally occurrinG InfeCtious agents linked to vaRious NeOPlasMS iN theiR host spECiES. we hAvE bEen EnGAgEd in aN onGoing efFort to charActErIze pathogeniC ViRuses, and idEntIfy the variouS hoSt factOrS thAT restRicT the rEplicaTIon cycLe of these ViRUses. MoUSe leukeMIA vIrusEs (MLVs)", "whitespace_perturbation": " 8-10% of host chromosomal  DNA. Retr oviru ses  we re  fir st r ecognized as n a tura lly occurring infectio us ag en t s li n ke d tovarious ne o p las ms  i n t he i rhostspe cies. W e have bee n e ng aged in an o n go ing effort  to  characteriz e p athoge ni c v i ruses , a nd id entify the va rious hos tf actors that re s t ri ct t he replication cy c le of these virus es. Mo us e  l e u kem iaviruses (M LV s)", "underscore_trick": " 8-10%_of host_chromosomal DNA. Retroviruses were_first recognized_as_naturally occurring_infectious_agents linked to_various neoplasms in_their host species. We_have been engaged_in_an ongoing effort to characterize pathogenic viruses, and identify the various host factors that_restrict_the replication_cycle_of_these viruses. Mouse leukemia viruses_(MLVs)"}
{"text": " of proteins in the context of their local cellular environment. Specifically, we succeeded in developing a robust pipeline for imaging the plasma membrane of cells with both 3D iPALM (interferometric photoactivation localization microcopy) and 3D transmission electron microscopy (TEM) of platinum replicas. In these studies we have", "synonym_substitution": "of proteins in the context of their local cellular environment. Specifically, we succeeded in developing a robust grapevine for image the plasma membrane of cells with both 3D iPALM (interferometric photoactivation localization microcopy) and 3D transmittance electron microscopy (TEM) of platinum replicas. In these study we have", "butter_fingers": " of proteins in the context of their local celluler envidonment. Rpecifically, we succeeded in dwvelokpng a robust pipeline for imagpng the poasme membrane of cells with both 3S iPANN (interferomettic photoacthvation localisagiln microcopy) and 3D transmission elestron mocgoscopy (TEM) of plauintm rsillcas. In these studies we have", "random_deletion": "of proteins in the context of their environment. we succeeded developing a robust membrane cells with both iPALM (interferometric photoactivation microcopy) and 3D transmission electron microscopy of platinum replicas. In these studies we have", "change_char_case": " of proteins in the context of tHeir local cEllulAr eNviRoNmenT. SpeCifically, we sucCEedeD in developing a robust piPelinE fOR imaGInG the pLasma meMBrANE of CeLlS wiTh BOtH 3D iPAlM (iNterferOmetric phoToaCtIvation localIZaTion microcOpy) And 3D transmisSioN electRoN miCRoscoPy (TeM) of pLatinuM ReplicAs. In these StUDies we HAve", "whitespace_perturbation": " of proteins in the contex t of their  loca l c ell ul ar e nvir onment. Specif i call y, we succeeded in dev elopi ng a ro b us t pip eline f o ri m agi ng  t hepl a sm a mem bra ne of c ells withbot h3D iPALM (in t er ferometric  ph otoactivatio n l ocaliz at ion micro cop y) an d 3D t r ansmis sion elec tr o n micr o scopy ( T E M)  ofplatinum replicas .  I n  these studies  we ha ve ", "underscore_trick": " of_proteins in_the context of their_local cellular_environment._Specifically, we_succeeded_in developing a_robust pipeline for_imaging the plasma membrane_of cells with_both_3D iPALM (interferometric photoactivation localization microcopy) and 3D transmission electron microscopy (TEM) of platinum_replicas._In these_studies_we_have"}
{"text": " a cohort of individuals with delayed pubertal development and Chiari type 1 malformations whose genomic DNA will soon be sent for ES, based on discoveries made through our phenotyping protocol. Analysis of these data has the potential to identify new non-reproductive features of IGD, as well as novel molecular pathways involved in", "synonym_substitution": "a cohort of individuals with delayed pubertal development and Chiari type 1 deformity whose genomic DNA will soon be mail for ES, based on discoveries made through our phenotyping protocol. psychoanalysis of these data has the potential to name modern non - reproductive feature of IGD, as well as novel molecular pathway involved in", "butter_fingers": " a fohort of individuals wiuh delayed pubertco devenopmenf and Chkari type 1 malformations whode genonic DNA will soon be sdnt for ED, based in dmscoveries made vgrough our phskotypnnj protocol. Analisis of thesa data has the putzntial to identify new non-reproductide featirfs of IGD, as wgll ax novsl molecular pathways involved in", "random_deletion": "a cohort of individuals with delayed pubertal Chiari 1 malformations genomic DNA will based discoveries made through phenotyping protocol. Analysis these data has the potential to new non-reproductive features of IGD, as well as novel molecular pathways involved in", "change_char_case": " a cohort of individuals with dElayed pubeRtal dEveLopMeNt anD ChiAri type 1 malformATionS whose genomic DNA will soOn be sEnT For Es, BaSed on DiscoveRIeS MAde ThRoUgh OuR PhEnotyPinG protocOl. Analysis Of tHeSe data has the POtEntial to idEntIfy new non-repRodUctive FeAtuREs of IgD, aS well As noveL MolecuLar pathwaYs INvolveD In", "whitespace_perturbation": " a cohort of individuals w ith delaye d pub ert alde velo pmen t and Chiari t y pe 1  malformations whose g enomi cD NA w i ll  soon  be sen t  f o r  ES ,ba sed  o n  d iscov eri es made  through o urph enotyping pr o to col. Analy sis  of these da tahas th epot e ntial  to  iden tify n e w non- reproduct iv e  featu r es of I G D ,as w ell as novel mole c ul a r pathways inv olvedin ", "underscore_trick": " a_cohort of_individuals with delayed pubertal_development and_Chiari_type 1_malformations_whose genomic DNA_will soon be_sent for ES, based_on discoveries made_through_our phenotyping protocol. Analysis of these data has the potential to identify new non-reproductive_features_of IGD,_as_well_as novel molecular pathways involved_in"}
{"text": " of normal cognition. Prior to our work on synaptic plasticity in area CA2, few groups had appreciated that the area was in fact a distinct region of the hippocampus and as a result, nothing was known about the how neurons in area CA2 function during even the simplest of behaviors such as exploration of an open field. We", "synonym_substitution": "of normal cognition. Prior to our work on synaptic plasticity in area CA2, few groups had prize that the sphere was in fact a distinct region of the hippocampus and as a resultant role, nothing was know about the how neurons in area CA2 officiate during even the childlike of behaviors such as exploration of an exposed field. We", "butter_fingers": " of normal cognition. Prior uo our work on syuqptic 'lasticjty in afea CA2, few groups had apprecmatee thau the area was in fxct a disninct reguon id the hippocampus and as w revnlt, nothing was known abogt the how neusovs in area CA2 function during even thq simplrsh of behaviors sucn as sqpooration of an open field. We", "random_deletion": "of normal cognition. Prior to our work plasticity area CA2, groups had appreciated fact distinct region of hippocampus and as result, nothing was known about the neurons in area CA2 function during even the simplest of behaviors such as of an open field. We", "change_char_case": " of normal cognition. Prior to oUr work on syNaptiC plAstIcIty iN areA CA2, few groups haD ApprEciated that the area was iN fact A dIStinCT rEgion Of the hiPPoCAMpuS aNd As a ReSUlT, nothIng Was knowN about the hOw nEuRons in area CA2 FUnCtion durinG evEn the simplesT of BehaviOrS suCH as exPloRatioN of an oPEn fielD. We", "whitespace_perturbation": " of normal cognition. Prio r to our w ork o n s yna pt ic p last icity in areaC A2,few groups had appreci atedth a t th e  a rea w as in f a ct a  di st in ctre g io n ofthe  hippoc ampus andasaresult, noth i ng  was known  ab out the howneu rons i nare a  CA2fun ction  durin g  eventhe simpl es t  of be h aviorss u ch  asexploration of an op e n field. We", "underscore_trick": " of_normal cognition._Prior to our work_on synaptic_plasticity_in area_CA2,_few groups had_appreciated that the_area was in fact_a distinct region_of_the hippocampus and as a result, nothing was known about the how neurons in_area_CA2 function_during_even_the simplest of behaviors such_as exploration of an open_field. We"}
{"text": " receptors that serve as TNF binding proteins. The specific aim of this project is to identify new mechanisms by which the release of soluble TNF receptors are regulated. We hypothesized that the mechanism of TNFR1 shedding might involve interactions with regulatory proteins. Utilizing a yeast two-hybrid approach, we identified ARTS-1 (A", "synonym_substitution": "receptors that serve as TNF binding proteins. The specific purpose of this undertaking is to identify new mechanism by which the handout of soluble TNF receptors are regulated. We speculate that the mechanism of TNFR1 shedding might involve interactions with regulative protein. Utilizing a yeast two - hybrid overture, we identified ARTS-1 (A", "butter_fingers": " refeptors that serve as TNN binding proteiuw. The vpecifjc aim ow this project is to identifb neq mecyanisms by which the rdlease of soluble TNF eeceptors ede regulated. Sc hypmvhesized that tme mechanisk of TNFR1 shedgivg might involve interactions with redulatoru oroteins. Utilieing s yeaan uwo-hybrid approach, we identified ZRTS-1 (A", "random_deletion": "receptors that serve as TNF binding proteins. aim this project to identify new of TNF receptors are We hypothesized that mechanism of TNFR1 shedding might involve with regulatory proteins. Utilizing a yeast two-hybrid approach, we identified ARTS-1 (A", "change_char_case": " receptors that serve as TNF biNding proteIns. ThE spEciFiC aim Of thIs project is to iDEntiFy new mechanisms by which The reLeASe of SOlUble TnF recepTOrS ARe rEgUlAteD. WE HyPotheSizEd that tHe mechanisM of tNfR1 shedding miGHt Involve intEraCtions with reGulAtory pRoTeiNS. UtilIziNg a yeAst two-HYbrid aPproach, we IdENtifieD aRTS-1 (A", "whitespace_perturbation": " receptors that serve as T NF binding  prot ein s.Th e sp ecif ic aim of this proj ect is to identify new  mech an i smsb ywhich  the re l ea s e  of  s ol ubl eT NF  rece pto rs areregulated.  We  h ypothesizedt ha t the mech ani sm of TNFR1she ddingmi ght invol veinter action s  withregulator yp rotein s . Utili z i ng  a y east two-hybrid a p pr o ach, we identi fied A RT S -1 ( A", "underscore_trick": " receptors_that serve_as TNF binding proteins._The specific_aim_of this_project_is to identify_new mechanisms by_which the release of_soluble TNF receptors_are_regulated. We hypothesized that the mechanism of TNFR1 shedding might involve interactions with regulatory_proteins._Utilizing a_yeast_two-hybrid_approach, we identified ARTS-1 (A"}
{"text": "pu is species-specific. However, in collaboration with Malcolm Martins lab we recently identified several primary Vpu isolates, such as DH12, capable of antagonizing both human and rhesus BST-2. We subsequently found that while Vpu interacts with human BST-2 primarily through their respective transmembrane domains", "synonym_substitution": "pu is species - specific. However, in collaboration with Malcolm Martins lab we recently identified several primary Vpu isolates, such as DH12, adequate to of antagonize both human and rhesus BST-2. We subsequently found that while Vpu interacts with human BST-2 primarily through their respective transmembrane domain", "butter_fingers": "pu ls species-specific. Howevtr, in collaboration with Malcomm Martivs lab we recently identifiev seceral primary Vpu isolates, ruch as DJ12, capablw of qntagoniziif both mbman zkd rhzsns BST-2. We subseauently fognd that while Vou interacts with human BST-2 primarily througn hheir respectide tgagsmejbrane domains", "random_deletion": "pu is species-specific. However, in collaboration with lab recently identified primary Vpu isolates, antagonizing human and rhesus We subsequently found while Vpu interacts with human BST-2 through their respective transmembrane domains", "change_char_case": "pu is species-specific. HoweveR, in collaboRatioN wiTh MAlColm martIns lab we recentLY ideNtified several primary VPu isoLaTEs, suCH aS DH12, caPable of ANtAGOniZiNg BotH hUMaN and rHesUs BST-2. We SubsequentLy fOuNd that while VPU iNteracts wiTh hUman BST-2 primaRilY throuGh TheIR respEctIve trAnsmemBRane doMains", "whitespace_perturbation": "pu is species-specific. Ho wever, incolla bor ati on  wit h Ma lcolm Martinsl ab w e recently identifiedsever al prim a ry  Vpuisolate s ,s u chas  D H12 ,c ap ableofantagon izing both  hu ma n and rhesus BS T-2. We su bse quently foun d t hat wh il e V p u int era cts w ith hu m an BST -2 primar il y  throu g h their r es pect ive transmembrane do m ains", "underscore_trick": "pu is_species-specific. However,_in collaboration with Malcolm_Martins lab_we_recently identified_several_primary Vpu isolates,_such as DH12,_capable of antagonizing both_human and rhesus_BST-2._We subsequently found that while Vpu interacts with human BST-2 primarily through their respective_transmembrane_domains"}
{"text": " series of highly specific intermediates. We identified residues of Tf1 RT that recognize specific intermediates of cDNA by screening large numbers of RT mutants. A combination of genetic assays and physical analyses identified a set of 35 mutations that inhibited integration without reducing reverse transcription. Our experiments focused on a cluster of mutations in ribonuclease H (", "synonym_substitution": "series of highly specific intermediates. We identified residues of Tf1 RT that accredit specific intermediate of cDNA by screening big number of RT mutants. A combination of genetic assay and forcible analyses identified a set of 35 mutations that inhibited consolidation without reducing reverse transcription. Our experiments focus on a cluster of mutation in ribonuclease H (", "butter_fingers": " segies of highly specific lntermediates. We identihied reaidues ow Tf1 RT that recognize specihic unternediates of cDNA by scfeening lwrge numvers if RT mutaifs. A combinatjln oy jenetic assays snd physicdl analyses idangiyied a set of 35 mutations that inhibieed intrggation without redlcyng dvvtrse transcription. Our experimenta focustd on a cluster of mutations in ribonuclease H (", "random_deletion": "series of highly specific intermediates. We identified Tf1 that recognize intermediates of cDNA RT A combination of assays and physical identified a set of 35 mutations inhibited integration without reducing reverse transcription. Our experiments focused on a cluster of in ribonuclease H (", "change_char_case": " series of highly specific intErmediates. we ideNtiFieD rEsidUes oF Tf1 RT that recogNIze sPecific intermediates of CDNA bY sCReenINg Large Numbers OF Rt MUtaNtS. A ComBiNAtIon of GenEtic assAys and physIcaL aNalyses identIFiEd a set of 35 muTatIons that inhiBitEd inteGrAtiON withOut ReducIng revERse traNscriptioN. OUR experIMents foCUSeD on a Cluster of mutationS In RIbonuclease H (", "whitespace_perturbation": " series of highly specific  intermedi ates.  We  id en tifi ed r esidues of Tf1 RT t hat recognize specific  inte rm e diat e sof cD NA by s c re e n ing  l ar genu m be rs of  RT  mutant s. A combi nat io n of genetic as says and p hys ical analyse s i dentif ie d a set o f 3 5 mut ations that i nhibitedin t egrati o n witho u t  r educ ing reverse trans c ri p tion. Our expe riment sf oc u s edona clusterof  muta t ions in ri b o n ucl e ase H (", "underscore_trick": " series_of highly_specific intermediates. We identified_residues of_Tf1_RT that_recognize_specific intermediates of_cDNA by screening_large numbers of RT_mutants. A combination_of_genetic assays and physical analyses identified a set of 35 mutations that inhibited integration_without_reducing reverse_transcription._Our_experiments focused on a cluster_of mutations in ribonuclease H_("}
{"text": " how neuronal activity can induce lasting modifications in neurons, we use a diverse collection of molecular, biochemical, electrophysiological, and imaging techniques. We use the hippocampal slice preparation from neonate and adult mice. The relatively simple laminar structure of the hippocampus, which itself plays an important role in learning and memory, allows electrophysiological", "synonym_substitution": "how neuronal activity can induce lasting modifications in nerve cell, we practice a divers collection of molecular, biochemical, electrophysiological, and imaging techniques. We practice the hippocampal slice preparation from neonate and adult mice. The relatively elementary laminar structure of the hippocampus, which itself plays an significant role in learning and memory, allow electrophysiological", "butter_fingers": " hoa neuronal activity can lnduce lasting modificavions ih neuronr, we use a diverse collectioi of molexular, biochemical, elecgrophysiopogical, qnd mmaging techniquxa. We usc the mippoeanpal slice prekaration frok neonate and ddjlc mice. The relatively simple laminar structirf of the hipposampls, whidh itself plays an important role jn leariing and memory, allows electrophysiologicwl", "random_deletion": "how neuronal activity can induce lasting modifications we a diverse of molecular, biochemical, use hippocampal slice preparation neonate and adult The relatively simple laminar structure of hippocampus, which itself plays an important role in learning and memory, allows electrophysiological", "change_char_case": " how neuronal activity can indUce lasting ModifIcaTioNs In neUronS, we use a diverse COlleCtion of molecular, biocheMical, ElECtroPHySioloGical, anD ImAGIng TeChNiqUeS. we Use thE hiPpocampAl slice preParAtIon from neonaTE aNd adult micE. ThE relatively sImpLe lamiNaR stRUcturE of The hiPpocamPUs, whicH itself plAyS An impoRTant rolE IN lEarnIng and memory, allowS ElECtrophysiologiCal", "whitespace_perturbation": " how neuronal activity can  induce la sting  mo dif ic atio ns i n neurons, weu se a  diverse collection of  mole cu l ar,b io chemi cal, el e ct r o phy si ol ogi ca l ,and i mag ing tec hniques. W e u se  the hippoca m pa l slice pr epa ration fromneo nate a nd  ad u lt mi ce.  Therelati v ely si mple lami na r  struc t ure oft h ehipp ocampus, which it s el f  plays an impo rtantro l ei n  le arn ing and me mo ry, a l lows el e ct r o p hys i ological", "underscore_trick": " how_neuronal activity_can induce lasting modifications_in neurons,_we_use a_diverse_collection of molecular,_biochemical, electrophysiological, and_imaging techniques. We use_the hippocampal slice_preparation_from neonate and adult mice. The relatively simple laminar structure of the hippocampus, which_itself_plays an_important_role_in learning and memory, allows_electrophysiological"}
{"text": " and functional characteristics were compared with those of monocytes exposed to factors known to generate either alternatively (interleukin-4 IL-4) or classically (macrophage colony-stimulating factor MCSF) activated M&#934;. IL-4 upregulated mRNA expression of CCL13, CCL15, CCL17", "synonym_substitution": "and functional characteristics were compared with those of monocytes expose to divisor known to generate either alternatively (interleukin-4 IL-4) or classically (macrophage colony - stimulating divisor MCSF) activated M&#934; . IL-4 upregulated mRNA expression of CCL13, CCL15, CCL17", "butter_fingers": " anf functional characterisuics were compareb with vhose or monocyges exposed to factors known ti gentgate either alternatixely (integleukin-4 IO-4) or xlassicallb (macropmcge ckpony-vvimulating factpr MCSF) acdivated M&#934;. IL-4 u[rdgblated mRNA expression of CCL13, CCL15, CCJ17", "random_deletion": "and functional characteristics were compared with those exposed factors known generate either alternatively colony-stimulating MCSF) activated M&#934;. upregulated mRNA expression CCL13, CCL15, CCL17", "change_char_case": " and functional characteristIcs were comPared WitH thOsE of mOnocYtes exposed to fACtorS known to generate either AlterNaTIvelY (InTerleUkin-4 IL-4) oR ClASSicAlLy (MacRoPHaGe colOny-StimulaTing factor mCSf) aCtivated M&#934;. IL-4 uPReGulated mRNa exPression of CCl13, CCl15, CCL17", "whitespace_perturbation": " and functional characteri stics were  comp are d w it h th oseof monocytes e x pose d to factors known togener at e  eit h er  alte rnative l y( i nte rl eu kin -4 IL -4) o r c lassica lly (macro pha ge  colony-stim u la ting facto r M CSF) activat edM&#934 ;.  IL - 4 upr egu lated  mRNAe xpress ion of CC L1 3 , CCL1 5 , CCL17 ", "underscore_trick": " and_functional characteristics_were compared with those_of monocytes_exposed_to factors_known_to generate either_alternatively (interleukin-4 IL-4)_or classically (macrophage colony-stimulating_factor MCSF) activated_M&#934;._IL-4 upregulated mRNA expression of CCL13, CCL15, CCL17"}
{"text": "hWT) MSCs. MC3R(hDM/hDM) impacted nutrient partitioning to generate increased adipose tissue that appeared metabolically healthy. These data confirmed the importance of MC3R signaling in human metabolism and suggested a previously-unrecognized role for the MC3R in adipose tissue development. Current studies are seeking", "synonym_substitution": "hWT) MSCs. MC3R(hDM / hDM) impacted nutrient partitioning to render increase adipose tissue that appeared metabolically healthy. These data confirm the importance of MC3R signaling in human metabolism and indicate a previously - unrecognized character for the MC3R in adipose tissue development. Current studies are seeking", "butter_fingers": "hWT) MSCs. MC3R(hDM/hDM) impacted nutrient partijiining vo genedate incfeased adipose tissue that a'peaeed mtnabolically healthy. Tfese data confirmwd tie importance of MC3R sigkcling ln huken metabolism akd suggesteg a previously-gnfeeognized role for the MC3R in adipose tissue dfvelopment. Curtent xeudiss are seeking", "random_deletion": "hWT) MSCs. MC3R(hDM/hDM) impacted nutrient partitioning to adipose that appeared healthy. These data signaling human metabolism and a previously-unrecognized role the MC3R in adipose tissue development. studies are seeking", "change_char_case": "hWT) MSCs. MC3R(hDM/hDM) impacted nUtrient parTitioNinG to GeNeraTe inCreased adipose TIssuE that appeared metabolicAlly hEaLThy. THEsE data ConfirmED tHE ImpOrTaNce Of mc3R SignaLinG in humaN metabolisM anD sUggested a preVIoUsly-unrecoGniZed role for thE MC3r in adiPoSe tISsue dEveLopmeNt. CurrENt studIes are seeKiNG", "whitespace_perturbation": "hWT) MSCs. MC3R(hDM/hDM) i mpacted nu trien t p art it ioni ng t o generate inc r ease d adipose tissue thatappea re d  met a bo lical ly heal t hy . The se  d ata  c o nf irmed  th e impor tance of M C3R  s ignaling inh um an metabol ism  and suggest eda prev io usl y -unre cog nized  rolef or the  MC3R inad i pose t i ssue de v e lo pmen t. Current studie s  a r e seeking", "underscore_trick": "hWT) MSCs._MC3R(hDM/hDM) impacted_nutrient partitioning to generate_increased adipose_tissue_that appeared_metabolically_healthy. These data_confirmed the importance_of MC3R signaling in_human metabolism and_suggested_a previously-unrecognized role for the MC3R in adipose tissue development. Current studies are seeking"}
{"text": " membrane-associated ARTS-1, decreased soluble TNFR1 release and increased membrane-associated TNFR1. ARTS-1 neither bound to TNFR2 nor altered its shedding, suggesting specificity for TNFR1. Although a GST-ARTS-1 fusion protein demonstrated selective aminopeptidase activity towards non", "synonym_substitution": "membrane - associated ARTS-1, decreased soluble TNFR1 release and increased membrane - consociate TNFR1. ARTS-1 neither tie to TNFR2 nor altered its shedding, suggesting specificity for TNFR1. Although a GST - ARTS-1 coalition protein demonstrated selective aminopeptidase activity towards non", "butter_fingers": " melbrane-associated ARTS-1, degreased soluble JNDR1 relxase ans increared membrane-associated TNFR1. ERTS-1 neityer bound to TNFR2 nor xltered ins sheddibg, snggesting specifmdity fov TNFD1. Altkongh a GST-ARTS-1 fosion proteit demonstrated sdlzctive aminopeptidase activity towarqs non", "random_deletion": "membrane-associated ARTS-1, decreased soluble TNFR1 release and TNFR1. neither bound TNFR2 nor altered TNFR1. a GST-ARTS-1 fusion demonstrated selective aminopeptidase towards non", "change_char_case": " membrane-associated ARTS-1, decReased soluBle TNfR1 rEleAsE and IncrEased membrane-aSSociAted TNFR1. ARTS-1 neither bouNd to TnFr2 Nor aLTeRed itS sheddiNG, sUGGesTiNg SpeCiFIcIty foR TNfR1. AlthoUgh a GST-ARTs-1 fuSiOn protein demONsTrated seleCtiVe aminopeptiDasE activItY toWArds nOn", "whitespace_perturbation": " membrane-associated ARTS- 1, decreas ed so lub leTN FR1rele ase and increa s ed m embrane-associated TNF R1. A RT S -1 n e it her b ound to TN F R 2 n or  a lte re d  i ts sh edd ing, su ggesting s pec if icity for TN F R1 . Although  aGST-ARTS-1 f usi on pro te ind emons tra ted s electi v e amin opeptidas ea ctivit y  toward s no n", "underscore_trick": " membrane-associated_ARTS-1, decreased_soluble TNFR1 release and_increased membrane-associated_TNFR1._ARTS-1 neither_bound_to TNFR2 nor_altered its shedding,_suggesting specificity for TNFR1._Although a GST-ARTS-1_fusion_protein demonstrated selective aminopeptidase activity towards non"}
{"text": "/stops progression of hearing loss and vision loss. 5. The phenotypic difference between NOMID and DIRA (no CNS, eye and ear inflammation in DIRA, compared to NOMID) and difference in skin manifestations, urticaria-like versus pustulosis, allow us to study", "synonym_substitution": "/stops progression of hearing loss and vision personnel casualty. 5. The phenotypical difference between NOMID and DIRA (no CNS, eye and ear excitement in DIRA, compare to NOMID) and difference in skin expression, urticaria - comparable versus pustulosis, allow us to analyze", "butter_fingers": "/stoos progression of hearinn loss and visiou loss. 5. The pgenotypiz difference between NOMID aid DURA (ni CNS, eye and ear inflxmmation pn DIRA, cimpaced to NOMID) and differekee in dkin nanifestations, urticaria-nike versus puvtjllsis, allow us to study", "random_deletion": "/stops progression of hearing loss and vision The difference between and DIRA (no in compared to NOMID) difference in skin urticaria-like versus pustulosis, allow us to", "change_char_case": "/stops progression of hearing Loss and visIon loSs. 5. THe pHeNotyPic dIfference betweEN NOMiD and DIRA (no CNS, eye and eaR inflAmMAtioN In dIRA, cOmpared TO NomiD) aNd DiFfeReNCe In skiN maNifestaTions, urticAriA-lIke versus pusTUlOsis, allow uS to Study", "whitespace_perturbation": "/stops progression of hear ing loss a nd vi sio n l os s. 5 . Th e phenotypic d i ffer ence between NOMID and  DIRA  ( n o CN S ,eye a nd eari nf l a mma ti on  in  D I RA , com par ed to N OMID) anddif fe rence in ski n  m anifestati ons , urticaria- lik e vers us  pu s tulos is,  allo w us t o  study ", "underscore_trick": "/stops progression_of hearing_loss and vision loss._5. The_phenotypic_difference between_NOMID_and DIRA (no_CNS, eye and_ear inflammation in DIRA,_compared to NOMID)_and_difference in skin manifestations, urticaria-like versus pustulosis, allow us to study"}
{"text": ", CCL18, CCL22, CLEC10A, MRC1, CADH1, CD274, and CD273 associated with alternative activation of M&#934; but not arginase 1. IL-4-cultured monocytes had a diminished ability to promote proliferation of both CD4(+) and CD", "synonym_substitution": ", CCL18, CCL22, CLEC10A, MRC1, CADH1, CD274, and CD273 associated with alternative activation of M&#934; but not arginase 1. IL-4 - cultured monocyte have a diminished ability to promote proliferation of both CD4(+) and certificate of deposit", "butter_fingers": ", CCP18, CCL22, CLEC10A, MRC1, CADH1, CD274, xnd CD273 associatgd with elternafive actkvation of M&#934; but not arginasx 1. IO-4-cultyred monocytes had a dkminished ability to kromote proliferavjon of njth DF4(+) anb RD", "random_deletion": ", CCL18, CCL22, CLEC10A, MRC1, CADH1, CD274, associated alternative activation M&#934; but not a ability to promote of both CD4(+) CD", "change_char_case": ", CCL18, CCL22, CLEC10A, MRC1, CADH1, CD274, and CD273 Associated With aLteRnaTiVe acTivaTion of M&#934; but not aRGinaSe 1. IL-4-cultured monocytes hAd a diMiNIsheD AbIlity To promoTE pROLifErAtIon Of BOtH CD4(+) anD CD", "whitespace_perturbation": ", CCL18, CCL22, CLEC10A, M RC1, CADH1 , CD2 74,  an dCD27 3 as sociated witha lter native activation of M &#934 ;b ut n o targin ase 1.I L- 4 - cul tu re d m on o cy tes h ada dimin ished abil ity  t o promote pr o li feration o f b oth CD4(+) a ndCD", "underscore_trick": ", CCL18,_CCL22, CLEC10A,_MRC1, CADH1, CD274, and_CD273 associated_with_alternative activation_of_M&#934; but not_arginase 1. IL-4-cultured_monocytes had a diminished_ability to promote_proliferation_of both CD4(+) and CD"}
{"text": " binding and entry. We are currently working on the XPR1 receptor for the xenotropic/polytropic MLVs (XP-MLVs). We have determined that, in mouse populations exposed to infectious virus, virus resistance is mediated by polymorphisms of the cell surface receptor. We have identified a total of six XPR", "synonym_substitution": "binding and entry. We are currently working on the XPR1 sense organ for the xenotropic / polytropic MLVs (XP - MLVs). We have determine that, in mouse populations expose to infectious virus, virus immunity is mediated by polymorphisms of the cellular telephone surface receptor. We have identified a sum of six XPR", "butter_fingers": " bijding and entry. We are cmrrently working on the XPR1 rsceptor wor the xenotropic/polytropic MOVs (XK-ILVs). We have deteroined than, in mousw pokulations exposed to infegcious yirus, tirus resistancg is mediateg by polymorphhsos of the cell surface receptor. We hade idenyivied a total os siq VPR", "random_deletion": "binding and entry. We are currently working XPR1 for the MLVs (XP-MLVs). We populations to infectious virus, resistance is mediated polymorphisms of the cell surface receptor. have identified a total of six XPR", "change_char_case": " binding and entry. We are curreNtly workinG on thE XPr1 reCePtor For tHe xenotropic/poLYtroPic MLVs (XP-MLVs). We have detErminEd THat, iN MoUse poPulatioNS eXPOseD tO iNfeCtIOuS viruS, viRus resiStance is meDiaTeD by polymorphISmS of the cell SurFace receptor. we hAve ideNtIfiED a totAl oF six XpR", "whitespace_perturbation": " binding and entry. We are  currently  work ing  on  t he X PR1receptor for t h e xe notropic/polytropic ML Vs (X P- M LVs) .  W e hav e deter m in e d  th at ,inmo u se  popu lat ions ex posed to i nfe ct ious virus,v ir us resista nce  is mediated  by  polym or phi s ms of  th e cel l surf a ce rec eptor. We  h a ve ide n tifieda to talof six XPR", "underscore_trick": " binding_and entry._We are currently working_on the_XPR1_receptor for_the_xenotropic/polytropic MLVs (XP-MLVs)._We have determined_that, in mouse populations_exposed to infectious_virus,_virus resistance is mediated by polymorphisms of the cell surface receptor. We have identified_a_total of_six_XPR"}
{"text": " of EpCAM as Langerhans cell surface marker and have extended our earlier studies and demonstrated that EpCAM expression, in conjunction with other surface markers, differentiates Langerhance cells from all other dendritic cells, including several recently described novel cutaneous dendritic cell subsets. In an effort to elucidate important aspects of EpCAM", "synonym_substitution": "of EpCAM as Langerhans cell surface marker and have extended our earlier report and attest that EpCAM expression, in conjunction with other airfoil markers, differentiates Langerhance cell from all early dendritic cells, including several recently described novel cutaneous dendritic cellular telephone subsets. In an effort to elucidate important aspect of EpCAM", "butter_fingers": " of EpCAM as Langerhans celu surface market qnd hate extehded our earlier studies and demonstcatee thau EpCAM expression, kn conjunbtion wity otier surface markxds, diffcxentizbes Lcnjerhance cells nrom all otver dendritic weuld, including several recently descrifed novrl cutaneous denqritpc celm subsets. In an effort to elucidats imporuant aspects of EpVAM", "random_deletion": "of EpCAM as Langerhans cell surface marker extended earlier studies demonstrated that EpCAM surface differentiates Langerhance cells all other dendritic including several recently described novel cutaneous cell subsets. In an effort to elucidate important aspects of EpCAM", "change_char_case": " of EpCAM as Langerhans cell suRface markeR and hAve ExtEnDed oUr eaRlier studies anD DemoNstrated that EpCAM expreSsion, In COnjuNCtIon wiTh other SUrFACe mArKeRs, dIfFErEntiaTes langerhAnce cells fRom AlL other dendriTIc Cells, incluDinG several receNtlY descrIbEd nOVel cuTanEous dEndritIC cell sUbsets. In aN eFFort to ELucidatE IMpOrtaNt aspects of EpCAM", "whitespace_perturbation": " of EpCAM as Langerhans ce ll surface  mark erand  h aveexte nded our earli e r st udies and demonstrated  that  E p CAMe xp ressi on, inc on j u nct io nwit ho th er su rfa ce mark ers, diffe ren ti ates Langerh a nc e cells fr omall other de ndr itic c el ls, inclu din g sev eral r e cently  describe dn ovel c u taneous d en drit ic cell subsets.I na n effort to el ucidat ei mp o r tan t a spects ofEp CAM", "underscore_trick": " of_EpCAM as_Langerhans cell surface marker_and have_extended_our earlier_studies_and demonstrated that_EpCAM expression, in_conjunction with other surface_markers, differentiates Langerhance_cells_from all other dendritic cells, including several recently described novel cutaneous dendritic cell subsets._In_an effort_to_elucidate_important aspects of EpCAM"}
{"text": "atal PCB Exposure: We examined the association between fetal loss in previous pregnancies and DDE levels that were in a range where effects had been seen in two other studies. Complete data were available for 2,380 subjects, of whom 361 were born preterm and 221 were small-for-gestational age. We examined maternal D", "synonym_substitution": "atal PCB Exposure: We examined the association between fetal loss in former pregnancy and DDE floor that were in a range where effect had been understand in two other studies. arrant datum were available for 2,380 subjects, of whom 361 were born preterm and 221 were small - for - gestational age. We examined enate D", "butter_fingers": "atap PCB Exposure: We examintd the associatiou betwexn fetam loss iv previous pregnancies and DVE lwvels that were in a range dhere effvcts had veen ween in two other studiea. Com'lxte data were ayailable fos 2,380 subjects, of wfol 361 were born preterm and 221 were smalj-for-gesyahional age. We gxamimqd mznevnal D", "random_deletion": "atal PCB Exposure: We examined the association loss previous pregnancies DDE levels that effects been seen in other studies. Complete were available for 2,380 subjects, of 361 were born preterm and 221 were small-for-gestational age. We examined maternal D", "change_char_case": "atal PCB Exposure: We examined The associaTion bEtwEen FeTal lOss iN previous pregnANcieS and DDE levels that were iN a ranGe WHere EFfEcts hAd been sEEn IN Two OtHeR stUdIEs. complEte Data werE available For 2,380 SuBjects, of whom 361 WErE born preteRm aNd 221 were small-fOr-gEstatiOnAl aGE. We exAmiNed maTernal d", "whitespace_perturbation": "atal PCB Exposure: We exam ined the a ssoci ati onbe twee n fe tal loss in pr e viou s pregnancies and DDElevel st hatw er e ina range wh e r e e ff ec tsha d  b een s een  in two  other stu die s.  Complete da t awere avail abl e for 2,380sub jects,  o f w h om 36 1 w ere b orn pr e term a nd 221 we re small- f or-gest a t io nalage. We examinedm at e rnal D", "underscore_trick": "atal PCB_Exposure: We_examined the association between_fetal loss_in_previous pregnancies_and_DDE levels that_were in a_range where effects had_been seen in_two_other studies. Complete data were available for 2,380 subjects, of whom 361 were born_preterm_and 221_were_small-for-gestational_age. We examined maternal D"}
{"text": " severely overweight children (6-12y) who manifested hyperinsulinemia and insulin resistance. We concluded that metformin, added to a monthly behavioral program, significantly improved weight loss, insulin resistance, and cholesterol over a 6-month interval in severely overweight, insulin-resistant children. We recently reported how the pharmacokinetics of metformin", "synonym_substitution": "severely overweight children (6 - 12y) who manifested hyperinsulinemia and insulin underground. We conclude that metformin, added to a monthly behavioral program, significantly better weight loss, insulin resistor, and cholesterol over a 6 - calendar month interval in severely overweight, insulin - resistant children. We recently report how the pharmacokinetics of metformin", "butter_fingers": " segerely overweight childrtn (6-12y) who manifestgd hypermnsulinsmia and insulin resistance. We conclnded that metformin, added to a oonthly bvhavioral projram, significantly improyzd wejnht lmws, insulin reslstance, and cholesterol oeef c 6-month interval in severely overweidht, insilln-resistant chyldrtn. Re rsbektly reported how the pharmacokihetics mf metformin", "random_deletion": "severely overweight children (6-12y) who manifested hyperinsulinemia resistance. concluded that added to a weight insulin resistance, and over a 6-month in severely overweight, insulin-resistant children. We reported how the pharmacokinetics of metformin", "change_char_case": " severely overweight childreN (6-12y) who manifEsted HypEriNsUlinEmia And insulin resiSTancE. We concluded that metforMin, adDeD To a mONtHly beHavioraL PrOGRam, SiGnIfiCaNTlY imprOveD weight Loss, insuliN reSiStance, and choLEsTerol over a 6-MonTh interval in SevErely oVeRweIGht, inSulIn-resIstant CHildreN. We recentLy REporteD How the pHARmAcokInetics of metformiN", "whitespace_perturbation": " severely overweight child ren (6-12y ) who  ma nif es tedhype rinsulinemia a n d in sulin resistance. We c onclu de d  tha t  m etfor min, ad d ed t o a  m on thl yb eh avior alprogram , signific ant ly  improved we i gh t loss, in sul in resistanc e,and ch ol est e rol o ver  a 6- monthi nterva l in seve re l y over w eight,i n su lin- resistant childre n .W e recently rep ortedho w  t h e  ph arm acokinetic sof me t formin", "underscore_trick": " severely_overweight children_(6-12y) who manifested hyperinsulinemia_and insulin_resistance._We concluded_that_metformin, added to_a monthly behavioral_program, significantly improved weight_loss, insulin resistance,_and_cholesterol over a 6-month interval in severely overweight, insulin-resistant children. We recently reported how_the_pharmacokinetics of_metformin"}
{"text": "ammaretrovirus genomes, many of which can produce infectious and pathogenic viruses. Second, there are also host factors that interfere directly with virus infection and replication, and we are particularly interested in those factors that inhibit virus entry and the early post-entry stages of the virus replicative cycle. These host factors affect different stages", "synonym_substitution": "ammaretrovirus genomes, many of which can produce infectious and pathogenic viruses. Second, there be besides host factors that intervene directly with virus contagion and replication, and we are particularly concerned in those factors that inhibit virus entry and the early post - entry phase of the virus replicative cycle. These host agent affect different stage", "butter_fingers": "ammwretrovirus genomes, many of which can ptoeuce iifectiohs and pxthogenic viruses. Second, thece aee alwo host factors that ivterfere firectly witi virus infectioi and reijicaflon, aud we are particolarly interasted in those fxccors that inhibit virus entry and thq early plst-entry stagef of ehe bprms replicative cycle. These host ractors affect diffetent stages", "random_deletion": "ammaretrovirus genomes, many of which can produce pathogenic Second, there also host factors infection replication, and we particularly interested in factors that inhibit virus entry and early post-entry stages of the virus replicative cycle. These host factors affect different", "change_char_case": "ammaretrovirus genomes, many Of which can ProduCe iNfeCtIous And pAthogenic virusES. SecOnd, there are also host facTors tHaT InteRFeRe dirEctly wiTH vIRUs iNfEcTioN aND rEplicAtiOn, and we Are particuLarLy Interested in THoSe factors tHat Inhibit virus EntRy and tHe EarLY post-EntRy staGes of tHE virus ReplicatiVe CYcle. ThESe host fACToRs afFect different stagES", "whitespace_perturbation": "ammaretrovirus genomes, ma ny of whic h can  pr odu ce  inf ecti ous and pathog e nicviruses. Second, there  areal s o ho s tfacto rs that in t e rfe re  d ire ct l ywithvir us infe ction andrep li cation, andw eare partic ula rly interest edin tho se  fa c torstha t inh ibit v i rus en try and t he earlyp ost-ent r y  s tage s of the virus re p li c ative cycle. T hese h os t  f a c tor s a ffect diff er ent s t ages", "underscore_trick": "ammaretrovirus genomes,_many of_which can produce infectious_and pathogenic_viruses._Second, there_are_also host factors_that interfere directly_with virus infection and_replication, and we_are_particularly interested in those factors that inhibit virus entry and the early post-entry stages_of_the virus_replicative_cycle._These host factors affect different_stages"}
{"text": " of FRET standards to aid in the interpretation of FRET analysis. In the course of this study we have identified two important potential artifacts that can complicate the proper interpretation of FRET analysis. 2. We are also in the final data collection stage for a study describing the generation of Homo-FRET standards that", "synonym_substitution": "of FRET standards to aid in the interpretation of FRET analysis. In the path of this discipline we have identified two important potential artifact that can complicate the proper interpretation of FRET analysis. 2. We are also in the concluding datum collection stage for a study describing the generation of Homo - FRET standard that", "butter_fingers": " of FRET standards to aid ik the interpretajiin of HRET anzlysis. Iv the course of this study wx hace idtutified two importang potentiwl artifqcts rhat can complicatc the iropex mnterpretation pf FRET andlysis. 2. We are ausl in the final data collection stagq for a shudy describind tht gqnerzniin of Homo-FRET standards that", "random_deletion": "of FRET standards to aid in the FRET In the of this study potential that can complicate proper interpretation of analysis. 2. We are also in final data collection stage for a study describing the generation of Homo-FRET standards", "change_char_case": " of FRET standards to aid in the InterpretaTion oF FReT aNaLysiS. In tHe course of this STudy We have identified two impOrtanT pOTentIAl ArtifActs thaT CaN COmpLiCaTe tHe PRoPer inTerPretatiOn of FRET anAlySiS. 2. We are also in THe Final data cOllEction stage fOr a Study dEsCriBIng thE geNeratIon of HOMo-FRET Standards ThAT", "whitespace_perturbation": " of FRET standards to aidin the int erpre tat ion  o f FR ET a nalysis. In th e  cou rse of this study we h ave i de n tifi e dtwo i mportan t  p o t ent ia lart if a ct s tha t c an comp licate the  pr op er interpret a ti on of FRET  an alysis. 2. W e a re als oint he fi nal  data  colle c tion s tage foras tudy d e scribin g th e ge neration of Homo- F RE T  standards tha t", "underscore_trick": " of_FRET standards_to aid in the_interpretation of_FRET_analysis. In_the_course of this_study we have_identified two important potential_artifacts that can_complicate_the proper interpretation of FRET analysis. 2. We are also in the final data_collection_stage for_a_study_describing the generation of Homo-FRET_standards that"}
{"text": " epistatic interactions with neurotrophic and dopaminergic processes that modulate AKT1 effects. AKT1 modulation via pharmaceuticals effected cognition and PF-MTL brain structure in SZ. Therefore, AKT1 and related neuroplasticity and developmental pathways may influence cognition and risk for SZ through effects that may be pharmacologically modifiable", "synonym_substitution": "epistatic interactions with neurotrophic and dopaminergic processes that modulate AKT1 effects. AKT1 transition via pharmaceutical effected cognition and PF - MTL brain social organization in SZ. Therefore, AKT1 and related neuroplasticity and developmental pathway may influence cognition and risk for SZ through effect that may be pharmacologically modifiable", "butter_fingers": " eplstatic interactions witm neurotrophic aue dopakinergjc procerses that modulate AKT1 effecvs. AJT1 moeulation via pharmaceugicals efvected cigniuion and PF-MTL brejn strugcure jk SZ. Chxrefore, AKT1 and related nauroplasticity avd developmental pathways may influense cognotlon and risk fjr SE trroufh effects that may be pharmacologjcally kodifiable", "random_deletion": "epistatic interactions with neurotrophic and dopaminergic processes AKT1 AKT1 modulation pharmaceuticals effected cognition SZ. AKT1 and related and developmental pathways influence cognition and risk for SZ effects that may be pharmacologically modifiable", "change_char_case": " epistatic interactions with NeurotrophIc and DopAmiNeRgic ProcEsses that modulATe AKt1 effects. AKT1 modulation vIa phaRmACeutICaLs effEcted coGNiTIOn aNd pF-mTL BrAIn StrucTurE in SZ. ThErefore, AKT1 And ReLated neuroplAStIcity and deVelOpmental pathWayS may inFlUenCE cognItiOn and Risk foR sZ throUgh effectS tHAt may bE PharmacOLOgIcalLy modifiable", "whitespace_perturbation": " epistatic interactions wi th neurotr ophic  an d d op amin ergi c processes th a t mo dulate AKT1 effects. A KT1 m od u lati o nvia p harmace u ti c a lsef fe cte dc og nitio n a nd PF-M TL brain s tru ct ure in SZ. T h er efore, AKT 1 a nd related n eur oplast ic ity and d eve lopme ntal p a thways  may infl ue n ce cog n ition a n d  r iskfor SZ through ef f ec t s that may bepharma co l og i c all y m odifiable", "underscore_trick": " epistatic_interactions with_neurotrophic and dopaminergic processes_that modulate_AKT1_effects. AKT1_modulation_via pharmaceuticals effected_cognition and PF-MTL_brain structure in SZ._Therefore, AKT1 and_related_neuroplasticity and developmental pathways may influence cognition and risk for SZ through effects that_may_be pharmacologically_modifiable"}
{"text": " elevated levels of pro-fibrotic cytokinescharacterize filarial infection-induced lymphatic pathology. Filarial-induced CD4+ and CD8+ responses have been characterized fully (using microarray/quantitative RT-PCR) in both the generally more-responsive expatriate patients and the less responsive indigenous (with lifelong exposure)", "synonym_substitution": "elevated levels of pro - fibrotic cytokinescharacterize filarial infection - induced lymphatic pathology. Filarial - induce CD4 + and CD8 + answer have been characterized fully (using microarray / quantitative RT - PCR) in both the broadly more - responsive expatriate patients and the less reactive indigenous (with lifelong exposure )", "butter_fingers": " elfvated levels of pro-fibrutic cytokinesckqractecize fimarial ivfection-induced lymphatic pavholigy. Fularial-induced CD4+ and ZD8+ respondes have beei characterized hhlly (uslug midvoarrcy/wuantitative RJ-PCR) in both the generally murz-responsive expatriate patients and ehe lesx gesponsive indygenpts (wjnh lifelong exposure)", "random_deletion": "elevated levels of pro-fibrotic cytokinescharacterize filarial infection-induced Filarial-induced and CD8+ have been characterized both generally more-responsive expatriate and the less indigenous (with lifelong exposure)", "change_char_case": " elevated levels of pro-fibrotIc cytokineScharActEriZe FilaRial Infection-inducED lymPhatic pathology. FilariaL-induCeD cD4+ anD cD8+ RespoNses havE BeEN ChaRaCtEriZeD FuLly (usIng MicroarRay/quantitAtiVe rT-PCR) in both tHE gEnerally moRe-rEsponsive expAtrIate paTiEntS And thE leSs resPonsivE IndigeNous (with lIfELong exPOsure)", "whitespace_perturbation": " elevated levels of pro-fi brotic cyt okine sch ara ct eriz e fi larial infecti o n-in duced lymphatic pathol ogy.Fi l aria l -i nduce d CD4+a nd C D8+  r es pon se s  h ave b een  charac terized fu lly  ( using microa r ra y/quantita tiv e RT-PCR) in  bo th the  g ene r allymor e-res ponsiv e  expat riate pat ie n ts and the les s re spon sive indigenous ( w it h  lifelong expo sure)", "underscore_trick": " elevated_levels of_pro-fibrotic cytokinescharacterize filarial infection-induced_lymphatic pathology._Filarial-induced_CD4+ and_CD8+_responses have been_characterized fully (using_microarray/quantitative RT-PCR) in both_the generally more-responsive_expatriate_patients and the less responsive indigenous (with lifelong exposure)"}
{"text": " compared with those in the neighboring regions. In addition, we have found that a regulator of G-protein signaling (RGS-14), and adenosine A1 receptors (A1Rs), which are highly enriched in CA2, are also negative regulators of plasticity in CA2. We have also found that the social ne", "synonym_substitution": "compared with those in the neighboring regions. In addition, we have found that a governor of deoxyguanosine monophosphate - protein signaling (RGS-14), and adenosine A1 receptors (A1Rs), which are highly enrich in CA2, are besides negative regulators of plasticity in CA2. We have besides discover that the social ne", "butter_fingers": " colpared with those in the neighboring reyuons. Ii additjon, we hxve found that a regulator oh G-peoteib signaling (RGS-14), and addnosine A1 receptoes (A1Cs), which are higimy enrigked ih CA2, crx also negative regulatorv of plasticitf kn CA2. We have also found that the socyal ne", "random_deletion": "compared with those in the neighboring regions. we found that regulator of G-protein receptors which are highly in CA2, are negative regulators of plasticity in CA2. have also found that the social ne", "change_char_case": " compared with those in the neiGhboring reGions. in aDdiTiOn, we Have Found that a reguLAtor Of G-protein signaling (RGS-14), And adEnOSine a1 ReCeptoRs (A1Rs), whICh ARE hiGhLy EnrIcHEd In CA2, aRe aLso negaTive regulaTorS oF plasticity iN cA2. we have also FouNd that the socIal Ne", "whitespace_perturbation": " compared with those in th e neighbor ing r egi ons .In a ddit ion, we have f o undthat a regulator of G- prote in sign a li ng (R GS-14), an d ade no si neA1 re cepto rs(A1Rs),  which are  hi gh ly enrichedi nCA2, are a lso  negative re gul atorsof  pl a stici tyin CA 2. Weh ave al so foundth a t thes ocial n e ", "underscore_trick": " compared_with those_in the neighboring regions._In addition,_we_have found_that_a regulator of_G-protein signaling (RGS-14),_and adenosine A1 receptors_(A1Rs), which are_highly_enriched in CA2, are also negative regulators of plasticity in CA2. We have also_found_that the_social_ne"}
{"text": " its ability to maintain TACE in an inactive state, independent of a cysteine switch mechanism. We synthesized a 37-amino acid peptide, corresponding to TACE amino acids 18 to 54 (N-TACE18-54), and assessed whether it possessed TACE inhibitory activity. The N-TACE18-54 amino", "synonym_substitution": "its ability to maintain TACE in an inactive state, independent of a cysteine substitution mechanism. We synthesize a 37 - amino acid peptide, corresponding to TACE amino acids 18 to 54 (N - TACE18 - 54), and tax whether it own TACE inhibitory activity. The N - TACE18 - 54 amino", "butter_fingers": " itd ability to maintain TAGE in an inactivg wtate, mndepensent of x cysteine switch mechanism. Xe stnthewized a 37-amino acid pepgide, corrvsponding to UACE amino acids 18 to 54 (N-TAGZ18-54), and wssevwed whether it possessed TACE inhibitosy aetivity. The N-TACE18-54 amino", "random_deletion": "its ability to maintain TACE in an independent a cysteine mechanism. We synthesized to amino acids 18 54 (N-TACE18-54), and whether it possessed TACE inhibitory activity. N-TACE18-54 amino", "change_char_case": " its ability to maintain TACE iN an inactivE statE, inDepEnDent Of a cYsteine switch mEChanIsm. We synthesized a 37-amino Acid pEpTIde, cORrEsponDing to TacE AMIno AcIdS 18 to 54 (n-TacE18-54), And asSesSed whetHer it posseSseD TaCE inhibitorY AcTivity. The N-tACe18-54 amino", "whitespace_perturbation": " its ability to maintain T ACE in aninact ive  st at e, i ndep endent of a cy s tein e switch mechanism. We  synt he s ized a37-am ino aci d  p e p tid e,  c orr es p on dingtoTACE am ino acids18to  54 (N-TACE1 8 -5 4), and as ses sed whetheritposses se d T A CE in hib itory  activ i ty. Th e N-TACE1 8- 5 4 amin o ", "underscore_trick": " its_ability to_maintain TACE in an_inactive state,_independent_of a_cysteine_switch mechanism. We_synthesized a 37-amino_acid peptide, corresponding to_TACE amino acids_18_to 54 (N-TACE18-54), and assessed whether it possessed TACE inhibitory activity. The N-TACE18-54 amino"}
{"text": " distribution of the molecular assemblies control the phenotypes of the cells. We demonstrated that enzyme instructed self-assembly makes it possible to modulate the spatiotemporal profiles of small molecules in a cellular environment. Objective 1: Develop a FV-based gene therapy approach for the treatment of subjects with LAD-1. 1.", "synonym_substitution": "distribution of the molecular assemblies control the phenotypes of the cells. We attest that enzyme instruct self - assembly makes it possible to regulate the spatiotemporal profiles of small atom in a cellular environment. Objective 1: build up a FV - based gene therapy access for the treatment of subjects with LAD-1. 1.", "butter_fingers": " didtribution of the molecuuar assemblies eintrol the pgenotyper of the cells. We demonstratxd tyat ebzyme instructed self-arsembly mwkes it possmble to modulate the spabnotemllral 'rofiles of smakl moleculas in a celluldr euvironment. Objective 1: Develop a FV-bafed genr hherapy approash fpw ths treatment of subjects with LAD-1. 1.", "random_deletion": "distribution of the molecular assemblies control the the We demonstrated enzyme instructed self-assembly the profiles of small in a cellular Objective 1: Develop a FV-based gene approach for the treatment of subjects with LAD-1. 1.", "change_char_case": " distribution of the moleculaR assemblieS contRol The PhEnotYpes Of the cells. We deMOnstRated that enzyme instrucTed seLf-ASsemBLy Makes It possiBLe TO ModUlAtE thE sPAtIotemPorAl profiLes of small MolEcUles in a celluLAr EnvironmenT. ObJective 1: DevelOp a fV-baseD gEne THerapY apProacH for thE TreatmEnt of subjEcTS with Lad-1. 1.", "whitespace_perturbation": " distribution of the molec ular assem blies  co ntr ol  the  phe notypes of the cell s. We demonstrated tha t enz ym e  ins t ru ctedself-as s em b l y m ak es  it  p o ss ibletomodulat e the spat iot em poral profil e sof small m ole cules in a c ell ular e nv iro n ment.  Ob jecti ve 1:D evelop  a FV-bas ed gene t h erapy a p p ro achfor the treatment of subjects withLAD-1.  1 . ", "underscore_trick": " distribution_of the_molecular assemblies control the_phenotypes of_the_cells. We_demonstrated_that enzyme instructed_self-assembly makes it_possible to modulate the_spatiotemporal profiles of_small_molecules in a cellular environment. Objective 1: Develop a FV-based gene therapy approach for_the_treatment of_subjects_with_LAD-1. 1."}
{"text": "als interactions with Leu180 of RT of HBVWT. This Leu180 interaction is also present in the complex of RT of HBVETV-RL180M/S202G/M204V. However, there is a distinct difference in the non-polar interactions of ETV-TP with the RT of", "synonym_substitution": "als interactions with Leu180 of RT of HBVWT. This Leu180 interaction is also present in the complex of RT of HBVETV - RL180M / S202G / M204V. However, there is a discrete remainder in the non - polar interactions of ETV - TP with the RT of", "butter_fingers": "als interactions with Leu180 on RT of HBVWT. Thnw Leu180 mnteracfion is xlso present in the complex lf RT od HBVETV-RL180M/S202G/M204V. Howevef, there id a distunct eifference in the kjn-pomwr iutxractions of ETY-TP with tha RT of", "random_deletion": "als interactions with Leu180 of RT of Leu180 is also in the complex there a distinct difference the non-polar interactions ETV-TP with the RT of", "change_char_case": "als interactions with Leu180 of Rt of HBVWT. ThIs Leu180 IntEraCtIon iS alsO present in the cOMpleX of RT of HBVETV-RL180M/S202G/M204V. HoWever, ThERe is A DiStincT differENcE IN thE nOn-PolAr INtEractIonS of ETV-Tp with the RT Of", "whitespace_perturbation": "als interactions with Leu1 80 of RT o f HBV WT.  Th is  Leu 180interaction is also  present in the comple x ofRT of H B VE TV-RL 180M/S2 0 2G / M 204 V.  H owe ve r ,there  is  a dist inct diffe ren ce  in the non- p ol ar interac tio ns of ETV-TP  wi th the  R T o f ", "underscore_trick": "als interactions_with Leu180_of RT of HBVWT._This Leu180_interaction_is also_present_in the complex_of RT of_HBVETV-RL180M/S202G/M204V. However, there is_a distinct difference_in_the non-polar interactions of ETV-TP with the RT of"}
{"text": "based approach to Cas9-mediated transgene knock-in, known as HITI, to achieve robust site-specific transgene integration within human CD34+ HSPCs. As proof-of-concept, a copGFP expression cassette was targeted to the genetic locus ITGB2 encoding the beta-2 integrin subunit CD18", "synonym_substitution": "based approach to Cas9 - mediated transgene knock - in, known as HITI, to achieve full-bodied web site - specific transgene consolidation within human CD34 + HSPCs. As proof - of - concept, a copGFP expression cassette was targeted to the genic locus ITGB2 encoding the beta-2 integrin fractional monetary unit CD18", "butter_fingers": "basfd approach to Cas9-mediattd transgene knock-in, knoxn as HJTI, to azhieve robust site-specific tcanstene untegration within humxn CD34+ HSPBs. As proif-of-roncept, a copGFP expressljn czdsetce was targeted jo the genethc locus ITGB2 anzobing the beta-2 integrin subunit CD18", "random_deletion": "based approach to Cas9-mediated transgene knock-in, known to robust site-specific integration within human copGFP cassette was targeted the genetic locus encoding the beta-2 integrin subunit CD18", "change_char_case": "based approach to Cas9-mediateD transgene Knock-In, kNowN aS HITi, to aChieve robust siTE-speCific transgene integratIon wiThIN humAN Cd34+ HSPCS. As prooF-Of-CONcePt, A cOpGfP EXpRessiOn cAssette Was targeteD to ThE genetic locuS iTgB2 encoding The Beta-2 integrin SubUnit CD18", "whitespace_perturbation": "based approach to Cas9-med iated tran sgene  kn ock -i n, k nown  as HITI, to a c hiev e robust site-specific  tran sg e ne i n te grati on with i nh u man  C D3 4+HS P Cs . Aspro of-of-c oncept, acop GF P expression ca ssette was  ta rgeted to th e g enetic  l ocu s  ITGB 2 e ncodi ng the beta-2  integrin  s u bunitC D18", "underscore_trick": "based approach_to Cas9-mediated_transgene knock-in, known as_HITI, to_achieve_robust site-specific_transgene_integration within human_CD34+ HSPCs. As_proof-of-concept, a copGFP expression_cassette was targeted_to_the genetic locus ITGB2 encoding the beta-2 integrin subunit CD18"}
{"text": " STUDIES: 1. Last year we published on a novel autoinflammatory disease DIRA, or deficiency of the IL-1 receptor antagonist and reported 4 founder mutations in the Newfoundland population, the Dutch, the Northern part of Puerto Rica around the city of Arecibo and Lebanon. Patients present with neonatal", "synonym_substitution": "STUDIES: 1. Last year we published on a fresh autoinflammatory disease DIRA, or lack of the IL-1 receptor antagonist and report 4 laminitis mutations in the Newfoundland population, the Dutch, the Northern part of Puerto Rica around the city of Arecibo and Lebanon. patient present with neonatal", "butter_fingers": " STKDIES: 1. Last year we publlshed on a novel autoinhlammatkry disexse DIRA, or deficiency of thx IL-1 receknor antagonist and reoorted 4 flunder mytatmons in the Newfoundland populzbion, chx Dutch, the Norjhern part ox Puerto Rica druuud the city of Arecibo and Lebanon. Pwtients pgesent with nejnatsj", "random_deletion": "STUDIES: 1. Last year we published on autoinflammatory DIRA, or of the IL-1 founder in the Newfoundland the Dutch, the part of Puerto Rica around the of Arecibo and Lebanon. Patients present with neonatal", "change_char_case": " STUDIES: 1. Last year we publisheD on a novel aUtoinFlaMmaToRy diSeasE DIRA, or deficieNCy of The IL-1 receptor antagonisT and rEpORted 4 FOuNder mUtationS In THE NeWfOuNdlAnD PoPulatIon, The DutcH, the NortheRn pArT of Puerto RicA ArOund the citY of arecibo and LeBanOn. PatiEnTs pREsent WitH neonAtal", "whitespace_perturbation": " STUDIES: 1. Last year wepublishedon anov elau toin flam matory disease DIRA , or deficiency of the  IL-1  r e cept o rantag onist a n dr e por te d4 f ou n de r mut ati ons inthe Newfou ndl an d population ,  t he Dutch,the  Northern pa rtof Pue rt o R i ca ar oun d the  cityo f Arec ibo and L eb a non. P a tientsp r es entwith neonatal", "underscore_trick": " STUDIES:_1. Last_year we published on_a novel_autoinflammatory_disease DIRA,_or_deficiency of the_IL-1 receptor antagonist_and reported 4 founder_mutations in the_Newfoundland_population, the Dutch, the Northern part of Puerto Rica around the city of Arecibo_and_Lebanon. Patients_present_with_neonatal"}
{"text": " reporting period. Persistent organic pollutants (POPs) are ubiquitous in the ecosystem and may be causing adverse health effects at background levels of exposure, via diet. The most important POPs are DDE (the major metabolite of the insecticide DDT), polychlorinated biphenyls (PCBs), and", "synonym_substitution": "reporting period. Persistent organic pollutant (pop) are ubiquitous in the ecosystem and may be causing adverse health effect at backdrop levels of exposure, via diet. The about important POPs are DDE (the major metabolite of the insecticide DDT), polychlorinated biphenyls (PCBs), and", "butter_fingers": " reoorting period. Persistenu organic pollutaurs (POPv) are hbiquitojs in the ecosystem and may ue cqusint adverse health effecgs at bacnground oeveow of exposnde, via diet. Tgc mosc mmportant POPs sre DDE (tha major metabonige of the insecticide DDT), polychlorinwted bilhfnyls (PCBs), and", "random_deletion": "reporting period. Persistent organic pollutants (POPs) are the and may causing adverse health exposure, diet. The most POPs are DDE major metabolite of the insecticide DDT), biphenyls (PCBs), and", "change_char_case": " reporting period. Persistent Organic polLutanTs (PoPs) ArE ubiQuitOus in the ecosysTEm anD may be causing adverse heAlth eFfECts aT BaCkgroUnd leveLS oF EXpoSuRe, Via DiET. THe mosT imPortant pOPs are DDE (The MaJor metabolitE Of The insectiCidE DDT), polychloRinAted biPhEnyLS (PCBs), And", "whitespace_perturbation": " reporting period. Persist ent organi c pol lut ant s(POP s) a re ubiquitousi n th e ecosystem and may be  caus in g  adv e rs e hea lth eff e ct s atba ck gro un d  l evels  of  exposu re, via di et.  T he most impo r ta nt POPs ar e D DE (the majo r m etabol it e o f  theins ectic ide DD T ), pol ychlorina te d  biphe n yls (PC B s ),  and ", "underscore_trick": " reporting_period. Persistent_organic pollutants (POPs) are_ubiquitous in_the_ecosystem and_may_be causing adverse_health effects at_background levels of exposure,_via diet. The_most_important POPs are DDE (the major metabolite of the insecticide DDT), polychlorinated biphenyls (PCBs),_and"}
{"text": " one specific Gai subunit, Nef might induce leukocyte migratory and homing defects in AIDS pathology. The members of the Toll-like Receptor (TLR) family play an important role in innate immunity. Of the 11 TLRs that have been identified, TLR1/TLR6, TLR2 and", "synonym_substitution": "one specific Gai subunit, Nef might induce leukocyte migratory and homing defects in AIDS pathology. The members of the price - alike Receptor (TLR) family play an crucial role in innate exemption. Of the 11 TLRs that have been identify, TLR1 / TLR6, TLR2 and", "butter_fingers": " onf specific Gai subunit, Ntf might induce lgujocyte migrafory and homing defects in AIDS pathlligy. Tye members of the Toll-uike Receitor (TLR) damiot play an mjportanb rols in nniate immunity. On the 11 TLRs that have beet kdzntified, TLR1/TLR6, TLR2 and", "random_deletion": "one specific Gai subunit, Nef might induce and defects in pathology. The members family an important role innate immunity. Of 11 TLRs that have been identified, TLR2 and", "change_char_case": " one specific Gai subunit, Nef mIght induce LeukoCytE miGrAtorY and Homing defects iN aIDS Pathology. The members of tHe TolL-lIKe ReCEpTor (TLr) family PLaY AN imPoRtAnt RoLE iN innaTe iMmunity. of the 11 TLRs tHat HaVe been identiFIeD, TLR1/TLR6, TLR2 And", "whitespace_perturbation": " one specific Gai subunit,  Nef might  indu celeu ko cyte  mig ratory and hom i ng d efects in AIDS patholo gy. T he memb e rs  of t he Toll - li k e  Re ce pt or(T L R)  fami lyplay an  important  ro le  in innate i m mu nity. Of t he11 TLRs that  ha ve bee nide n tifie d,TLR1/ TLR6,T LR2 an d", "underscore_trick": " one_specific Gai_subunit, Nef might induce_leukocyte migratory_and_homing defects_in_AIDS pathology. The_members of the_Toll-like Receptor (TLR) family_play an important_role_in innate immunity. Of the 11 TLRs that have been identified, TLR1/TLR6, TLR2 and"}
{"text": " cells to use in adoptive immunotherapy. These findings have been the basis for the development of a new model of repertoire organization in peripheral T cells in which we adopt the M. Cohn concept of a Protection as a repeating unit of specificities that insure an adequate number of responding cells irrespective of body volume; that is,", "synonym_substitution": "cells to use in adoptive immunotherapy. These findings have been the footing for the growth of a new model of repertory organization in peripheral triiodothyronine cells in which we espouse the M. Cohn concept of a Protection as a repeat unit of specificity that insure an adequate number of respond cells irrespective of soundbox volume; that is,", "butter_fingers": " cepls to use in adoptive iomunotherapy. Thgsw findmngs habe been ghe basis for the developmenv of a neq model of repertoire urganizatpon in peeiphtral T cells in wijch we adopt fme M. Eoin concept of a Protectiot as a repeatitg uuit of specificities that insure an wdequatr jumber of respjndimd cemls irrespective of body volume; thzt is,", "random_deletion": "cells to use in adoptive immunotherapy. These been basis for development of a in T cells in we adopt the Cohn concept of a Protection as repeating unit of specificities that insure an adequate number of responding cells irrespective body volume; that is,", "change_char_case": " cells to use in adoptive immunOtherapy. ThEse fiNdiNgs HaVe beEn thE basis for the deVElopMent of a new model of reperToire OrGAnizATiOn in pEripherAL T CELls In WhIch We ADoPt the m. CoHn concePt of a ProteCtiOn As a repeating UNiT of specifiCitIes that insurE an AdequaTe NumBEr of rEspOndinG cells IRrespeCtive of boDy VOlume; tHAt is,", "whitespace_perturbation": " cells to use in adoptiveimmunother apy.The sefi ndin gs h ave been the b a sisfor the development of  a ne wm odel of  repe rtoireo rg a n iza ti on  in  p e ri phera l T  cellsin which w e a do pt the M. Co h nconcept of  aProtection a s a  repea ti ngu nit o f s pecif icitie s  thatinsure an  a d equate numbero f  r espo nding cells irres p ec t ive of body vo lume;th a ti s ,", "underscore_trick": " cells_to use_in adoptive immunotherapy. These_findings have_been_the basis_for_the development of_a new model_of repertoire organization in_peripheral T cells_in_which we adopt the M. Cohn concept of a Protection as a repeating unit_of_specificities that_insure_an_adequate number of responding cells_irrespective of body volume; that_is,"}
{"text": " 1) Together with Dr. Brian Mozer of NHLBI, David Sandstrom is analyzing the role of Drosophila neuroligin, an ortholog of a gene implicated in autism, in the structure and function of a prototypical synapse, the larval neuromuscular junction. New developments include the demonstrations that that NLG protein", "synonym_substitution": "1) Together with Dr. Brian Mozer of NHLBI, David Sandstrom is analyzing the role of Drosophila neuroligin, an ortholog of a gene implicated in autism, in the social organization and affair of a prototypical synapse, the larval neuromuscular junction. newfangled development include the demonstrations that that NLG protein", "butter_fingers": " 1) Tlgether with Dr. Brian Moeer of NHLBI, Davib Sandsvrom is analyzivg the role of Drosophila nenrolugin, qn ortholog of a gene kmplicatef in autusm, mn the structure and fungcion kn a pxovotypical synapxe, the lareal neuromuscunaf lunction. New developments include thq demonxtgations that trat MJG pdotein", "random_deletion": "1) Together with Dr. Brian Mozer of Sandstrom analyzing the of Drosophila neuroligin, implicated autism, in the and function of prototypical synapse, the larval neuromuscular junction. developments include the demonstrations that that NLG protein", "change_char_case": " 1) Together with Dr. Brian Mozer oF NHLBI, DaviD SandStrOm iS aNalyZing The role of DrosoPHila Neuroligin, an ortholog of A gene ImPLicaTEd In autIsm, in thE StRUCtuRe AnD fuNcTIoN of a pRotOtypicaL synapse, thE laRvAl neuromuscuLAr Junction. NeW deVelopments inCluDe the dEmOnsTRatioNs tHat thAt NLG pROtein", "whitespace_perturbation": " 1) Together with Dr. Bria n Mozer of  NHLB I,Dav id  San dstr om is analyzin g  the  role of Drosophila ne uroli gi n , an or tholo g of ag en e imp li ca ted  i n  a utism , i n the s tructure a ndfu nction of ap ro totypicalsyn apse, the la rva l neur om usc u lar j unc tion.  New d e velopm ents incl ud e  the d e monstra t i on s th at that NLG prote i n", "underscore_trick": " 1)_Together with_Dr. Brian Mozer of_NHLBI, David_Sandstrom_is analyzing_the_role of Drosophila_neuroligin, an ortholog_of a gene implicated_in autism, in_the_structure and function of a prototypical synapse, the larval neuromuscular junction. New developments include_the_demonstrations that_that_NLG_protein"}
{"text": " have shown that the maintenance of the intestinal epithelium by Lgr5-expressing ISCs occurs via an asymmetric model of ISC division under normal homeostasis in addition to the previous prevailing model supporting symmetric division. In fact, our in vivo data examining mitotic spindle orientation and lineage traced progeny pairs indicate that the majority of ISC division", "synonym_substitution": "have shown that the maintenance of the intestinal epithelium by Lgr5 - expressing ISCs occurs via an asymmetrical exemplar of ISC division under normal homeostasis in addition to the former prevailing model defend symmetric division. In fact, our in vivo datum examine mitotic spindle orientation and descent traced progeny pairs argue that the majority of ISC division", "butter_fingers": " hage shown that the maintekance of the intgsrinal xpitheljum by Ler5-expressing ISCs occurs via ab asynmetric model of ISC dkvision ujder nornal iomeostasis in avsition bj ths preriius prevailing model sup[orting symmetsiz bivision. In fact, our in vivo data exwmining mltotic spindle oritntwtioh and lineage traced progeny pairs indicaue that the majoriyy of ISC division", "random_deletion": "have shown that the maintenance of the by ISCs occurs an asymmetric model homeostasis addition to the prevailing model supporting division. In fact, our in vivo examining mitotic spindle orientation and lineage traced progeny pairs indicate that the majority ISC division", "change_char_case": " have shown that the maintenanCe of the intEstinAl ePitHeLium By LgR5-expressing ISCS OccuRs via an asymmetric model Of ISC DiVIsioN UnDer noRmal homEOsTASis In AdDitIoN To The prEviOus prevAiling modeL suPpOrting symmetRIc Division. In FacT, our in vivo daTa eXaminiNg MitOTic spIndLe oriEntatiON and liNeage tracEd PRogeny PAirs indICAtE thaT the majority of ISC DIvISion", "whitespace_perturbation": " have shown that the maint enance ofthe i nte sti na l ep ithe lium by Lgr5-e x pres sing ISCs occurs via a n asy mm e tric mo del o f ISC d i vi s i onun de r n or m al  home ost asis in  additiontoth e previous p r ev ailing mod elsupporting s ymm etricdi vis i on. I n f act,our in vivo d ata exami ni n g mito t ic spin d l eorie ntation and linea g et raced progenypairsin d ic a t e t hat  the major it y ofI SC divi s io n ", "underscore_trick": " have_shown that_the maintenance of the_intestinal epithelium_by_Lgr5-expressing ISCs_occurs_via an asymmetric_model of ISC_division under normal homeostasis_in addition to_the_previous prevailing model supporting symmetric division. In fact, our in vivo data examining mitotic_spindle_orientation and_lineage_traced_progeny pairs indicate that the_majority of ISC division"}
{"text": "duced with FV-hCD18 revealed human CD18+ cells in both CD13+ myeloid and CD20+ lymphoid compartments. Using next-generation sequencing technology, a total of 101 unique integration sites were recovered in repopulating cells and revealed a polyclonal pattern of integration with no evidence of insertional mutagenesis or tumorigen", "synonym_substitution": "duced with FV - hCD18 revealed human CD18 + cells in both CD13 + myeloid and CD20 + lymphoid compartments. Using future - coevals sequencing technology, a total of 101 singular integration sites were recover in repopulating cell and revealed a polyclonal form of integration with no evidence of insertional mutagenesis or tumorigen", "butter_fingers": "ducfd with FV-hCD18 revealed hmman CD18+ cells in both CV13+ myelojd and CA20+ lymphoid compartments. Usinj nezt-gentgation sequencing tecfnology, a total od 101 uiique integratioi sites were rsgoverzd in repopulatikg cells ang revealed a pmlhcponal pattern of integration with nj evidemcf of insertionwl mltwgenssis or tumorigen", "random_deletion": "duced with FV-hCD18 revealed human CD18+ cells CD13+ and CD20+ compartments. Using next-generation 101 integration sites were in repopulating cells revealed a polyclonal pattern of integration no evidence of insertional mutagenesis or tumorigen", "change_char_case": "duced with FV-hCD18 revealed humAn CD18+ cells iN both cD13+ mYelOiD and cD20+ lyMphoid compartmENts. USing next-generation sequEncinG tEChnoLOgY, a totAl of 101 uniQUe INTegRaTiOn sItES wEre reCovEred in rEpopulatinG ceLlS and revealed A PoLyclonal paTteRn of integratIon With no EvIdeNCe of iNseRtionAl mutaGEnesis Or tumorigEn", "whitespace_perturbation": "duced with FV-hCD18 reveal ed human C D18+cel lsin  bot h CD 13+ myeloid an d  CD2 0+ lymphoid compartmen ts. U si n g ne x t- gener ation s e qu e n cin gte chn ol o gy , a t ota l of 10 1 unique i nte gr ation sitesw er e recovere d i n repopulati ngcellsan d r e veale d a  poly clonal patter n of inte gr a tion w i th no e v i de nceof insertional mu t ag e nesis or tumor igen", "underscore_trick": "duced with_FV-hCD18 revealed_human CD18+ cells in_both CD13+_myeloid_and CD20+_lymphoid_compartments. Using next-generation_sequencing technology, a_total of 101 unique_integration sites were_recovered_in repopulating cells and revealed a polyclonal pattern of integration with no evidence of_insertional_mutagenesis or_tumorigen"}
{"text": " translational trials related to modulation of the leptin signaling pathway using a melanocortin agonist called setmelanotide. Finally, we have initiated studies to examine the hypothesis that administration of colchicine can decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation (20). The Role of Gonad", "synonym_substitution": "translational trials related to modulation of the leptin signaling pathway use a melanocortin protagonist called setmelanotide. Finally, we have initiate study to examine the hypothesis that government of colchicine can decrease NLRP3 - activate inflammation and better obesity - related metabolic dysregulation (20). The Role of Gonad", "butter_fingers": " trwnslational trials relattd to modulation of the neptin signalivg pathway using a melanocorvin qgoniwt called setmelanotidd. Finally, we have iniuiated studies to examine the hgiothevms that adminisjration of cmlchicine can gezrzase NLRP3-activated inflammation and ymprove ohesity-related ietanjlic dysregulation (20). The Role of Gonad", "random_deletion": "translational trials related to modulation of the pathway a melanocortin called setmelanotide. Finally, examine hypothesis that administration colchicine can decrease inflammation and improve obesity-related metabolic dysregulation The Role of Gonad", "change_char_case": " translational trials relateD to modulatIon of The LepTiN sigNaliNg pathway using A MelaNocortin agonist called sEtmelAnOTide. fInAlly, wE have inITiATEd sTuDiEs tO eXAmIne thE hyPothesiS that adminIstRaTion of colchiCInE can decreaSe NlRP3-activated InfLammatIoN anD ImproVe oBesitY-relatED metabOlic dysreGuLAtion (20). THE Role of gONaD", "whitespace_perturbation": " translational trials rela ted to mod ulati onofth e le ptin  signaling pat h wayusing a melanocortin a gonis tc alle d  s etmel anotide .  F i n all y,  w e h av e  i nitia ted  studie s to exami neth e hypothesis th at adminis tra tion of colc hic ine ca ndec r easeNLR P3-ac tivate d  infla mmation a nd improv e  obesit y - re late d metabolic dysre g ul a tion (20). The  Roleof Go n a d", "underscore_trick": " translational_trials related_to modulation of the_leptin signaling_pathway_using a_melanocortin_agonist called setmelanotide._Finally, we have_initiated studies to examine_the hypothesis that_administration_of colchicine can decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation (20). The Role_of_Gonad"}
{"text": " the atomic scale. The combination of these methods provides our group with the unique tools to gain a multi-scale understanding of the structure, dynamics, and functions of proteins and protein complexes inside cells. Tissue functional properties are governed by physical and chemical processes occurring at cellular and subcellular length scales. Specifically, the physical state of tissues", "synonym_substitution": "the atomic scale. The combination of these methods provides our group with the alone creature to gain a multi - scale understanding of the structure, moral force, and functions of proteins and protein complexes inside cellular telephone. Tissue functional properties are regulate by physical and chemical processes occur at cellular and subcellular length scales. Specifically, the forcible state of tissues", "butter_fingers": " thf atomic scale. The combikation of these methods provises our eroup with the unique tools vo gqin a multi-scale understandkng of thv structuee, dbnamics, and funcvjons of protejks anb 'rotein complexgs inside cenls. Tissue funwtkoual properties are governed by physisal and cjemical procesfes pscurdpnn at cellular and subcellular lehgth sceles. Specificalky, the physical state of tlssufs", "random_deletion": "the atomic scale. The combination of these our with the tools to gain structure, and functions of and protein complexes cells. Tissue functional properties are governed physical and chemical processes occurring at cellular and subcellular length scales. Specifically, the state of tissues", "change_char_case": " the atomic scale. The combinatIon of these MethoDs pRovIdEs ouR groUp with the uniquE ToolS to gain a multi-scale undeRstanDiNG of tHE sTructUre, dynaMIcS, ANd fUnCtIonS oF PrOteinS anD proteiN complexes InsIdE cells. Tissue FUnCtional proPerTies are goverNed By physIcAl aND chemIcaL procEsses oCCurrinG at cellulAr ANd subcELlular lENGtH scaLes. Specifically, thE PhYSical state of tiSsues", "whitespace_perturbation": " the atomic scale. The com bination o f the semet ho ds p rovi des our groupw iththe unique tools to ga in amu l ti-s c al e und erstand i ng o f t he  s tru ct u re , dyn ami cs, and  functions  of  p roteins andp ro tein compl exe s inside cel ls.  Tissu efun c tiona l p roper ties a r e gove rned by p hy s ical a n d chemi c a lproc esses occurring a t  c e llular and sub cellul ar le n g thsca les. Speci fi cally ,  the ph y si c a l  st a te of tissues ", "underscore_trick": " the_atomic scale._The combination of these_methods provides_our_group with_the_unique tools to_gain a multi-scale_understanding of the structure,_dynamics, and functions_of_proteins and protein complexes inside cells. Tissue functional properties are governed by physical and_chemical_processes occurring_at_cellular_and subcellular length scales. Specifically,_the physical state of tissues"}
{"text": " exposed to these cognitive interventions, can disability in the performance of key everyday activities be delayed and independence maintained as subjects age into their 80s. We estimate power to detect effect sizes of 0.2 over 10 years for the cognitive abilities, everyday problem solving, and everyday speed and an effect size of 0.4 for everyday", "synonym_substitution": "exposed to these cognitive interventions, can disability in the performance of key casual bodily process be delayed and independence maintained as discipline long time into their 80s. We estimate might to detect impression sizes of 0.2 over 10 old age for the cognitive abilities, everyday trouble solving, and everyday speed and an effect size of 0.4 for everyday", "butter_fingers": " exoosed to these cognitive interventions, eqn disebility in the oerformance of key everyday ecticitiew be delayed and indepdndence mwintainee as wubjects ajs into bkeir 80a. We zsvimate power to detect efxect sizes of 0.2 oxex 10 years for the cognitive abilities, everydsy problem solvigg, amq evsgybay speed and an effect size of 0.4 for eneryday", "random_deletion": "exposed to these cognitive interventions, can disability performance key everyday be delayed and into 80s. We estimate to detect effect of 0.2 over 10 years for cognitive abilities, everyday problem solving, and everyday speed and an effect size of for everyday", "change_char_case": " exposed to these cognitive inTerventionS, can dIsaBilItY in tHe peRformance of key EVeryDay activities be delayed And inDePEndeNCe MaintAined as SUbJECts AgE iNto ThEIr 80S. We esTimAte poweR to detect eFfeCt Sizes of 0.2 over 10 yEArS for the cogNitIve abilities, EveRyday pRoBleM SolviNg, aNd eveRyday sPEed and An effect sIzE Of 0.4 for eVEryday", "whitespace_perturbation": " exposed to these cognitiv e interven tions , c andi sabi lity  in the perfor m ance  of key everyday activ ities  b e  del a ye d and  indepe n de n c e m ai nt ain ed as  subj ect s age i nto their80s .We estimatep ow er to dete cteffect sizes  of  0.2 o ve r 1 0  year s f or th e cogn i tive a bilities,  e v eryday problem s ol ving , and everyday sp e ed and an effectsize o f0 .4 f oreve ryday", "underscore_trick": " exposed_to these_cognitive interventions, can disability_in the_performance_of key_everyday_activities be delayed_and independence maintained_as subjects age into_their 80s. We_estimate_power to detect effect sizes of 0.2 over 10 years for the cognitive abilities,_everyday_problem solving,_and_everyday_speed and an effect size_of 0.4 for everyday"}
{"text": " and leptin compared with wild type or heterozygous children. Recent studies have confirmed greater adiposity in homozygous adults. Ongoing studies attempt to understand the mechanisms by which these sequence alterations impact body weight. We have initiated a study comparing energy balance during adaptation to a high-fat diet in humans with double-mutant and", "synonym_substitution": "and leptin compared with wild type or heterozygous children. late cogitation have confirmed great adiposity in homozygous adult. Ongoing studies attempt to sympathize the mechanisms by which these sequence alterations affect soundbox weight. We have broach a study comparing department of energy balance during adaptation to a high - fat diet in humans with double - mutant and", "butter_fingers": " anf leptin compared with wlld type or hetetozygous childden. Recevt studies have confirmed grxatee adikjsity in homozygour adults. Lngoing wtudmes attempt to uiserstand the jcchannsns by which thgse sequence alterations ikpxcc body weight. We have initiated a sttdy comlaging energy bajanct dtrinf adaptation to a high-fat diet in gumans xith double-mutamt and", "random_deletion": "and leptin compared with wild type or Recent have confirmed adiposity in homozygous understand mechanisms by which sequence alterations impact weight. We have initiated a study energy balance during adaptation to a high-fat diet in humans with double-mutant and", "change_char_case": " and leptin compared with wild Type or heteRozygOus ChiLdRen. REcenT studies have coNFirmEd greater adiposity in hoMozygOuS AdulTS. ONgoinG studieS AtTEMpt To UnDerStANd The meChaNisms by Which these SeqUeNce alteratioNS iMpact body wEigHt. We have initIatEd a stuDy ComPAring EneRgy baLance dURing adAptation tO a HIgh-fat DIet in huMANs With Double-mutant and", "whitespace_perturbation": " and leptin compared withwild typeor he ter ozy go us c hild ren. Recent st u dies  have confirmed greate r adi po s ityi nhomoz ygous a d ul t s . O ng oi ngst u di es at tem pt to u nderstandthe  m echanisms by wh ich theseseq uence altera tio ns imp ac t b o dy we igh t. We  havei nitiat ed a stud yc ompari n g energ y ba lanc e during adaptati o nt o a high-fat d iet in  h u ma n s  wi thdouble-mut an t and ", "underscore_trick": " and_leptin compared_with wild type or_heterozygous children._Recent_studies have_confirmed_greater adiposity in_homozygous adults. Ongoing_studies attempt to understand_the mechanisms by_which_these sequence alterations impact body weight. We have initiated a study comparing energy balance_during_adaptation to_a_high-fat_diet in humans with double-mutant_and"}
{"text": " different hippocampal subfields, we use molecular and biochemical methods with tissue harvested by laser capture microdissection (LCM). In addition, we now use in vivo recording and tracing techniques to address the role of the different hippocampal subregions in specific behaviors. One approach that we have taken to gain insight into the mechanisms of regulating", "synonym_substitution": "different hippocampal subfields, we use molecular and biochemical methods with tissue harvested by laser capture microdissection (LCM). In accession, we nowadays use in vivo recording and tracing techniques to cover the role of the different hippocampal subregions in specific behaviors. One access that we have taken to gain penetration into the mechanism of regulating", "butter_fingers": " divferent hippocampal subflelds, we use molgcylar aid biocgemical oethods with tissue harvestev by lasee capture microdissectkon (LCM). Ij additiin, wt now use in vivo recordiky and braciug techniques to address tve role of the dkfyerent hippocampal subregions in spesific brhwviors. One apptoach ehat we have taken to gain insight intk the mtchanisms of regulsting", "random_deletion": "different hippocampal subfields, we use molecular and with harvested by capture microdissection (LCM). in recording and tracing to address the of the different hippocampal subregions in behaviors. One approach that we have taken to gain insight into the mechanisms regulating", "change_char_case": " different hippocampal subfiElds, we use mOlecuLar And BiOcheMicaL methods with tiSSue hArvested by laser capture MicroDiSSectIOn (lCM). In AdditioN, We NOW usE iN vIvo ReCOrDing aNd tRacing tEchniques tO adDrEss the role of THe Different hIppOcampal subreGioNs in spEcIfiC BehavIorS. One aPproacH That we Have taken To GAin insIGht into THE mEchaNisms of regulating", "whitespace_perturbation": " different hippocampal sub fields, we  usemol ecu la r an d bi ochemical meth o ds w ith tissue harvested b y las er capt u re  micr odissec t io n (LC M) .Inad d it ion,wenow use  in vivo r eco rd ing and trac i ng  technique s t o address th e r ole of  t hed iffer ent  hipp ocampa l  subre gions insp e cificb ehavior s .  O ne a pproach that we h a ve taken to gaininsigh ti nt o the  me chanisms o fregul a ting", "underscore_trick": " different_hippocampal subfields,_we use molecular and_biochemical methods_with_tissue harvested_by_laser capture microdissection_(LCM). In addition,_we now use in_vivo recording and_tracing_techniques to address the role of the different hippocampal subregions in specific behaviors. One_approach_that we_have_taken_to gain insight into the_mechanisms of regulating"}
{"text": " macromolecules using anomalous small-angle X-ray scattering (ASAXS). In biology, osmotic pressure is particularly important in regulating and mediating physiological processes. Swelling pressure measurements probe the system in the large length scale range, thus providing information on the overall thermodynamic response. SANS and SAXS allow us to investigate", "synonym_substitution": "macromolecules using anomalous small - angle ten - re scattering (ASAXS). In biology, osmotic pressure is peculiarly important in regulating and mediating physiologic process. Swelling press measurements probe the system in the big length scale image, therefore providing information on the overall thermodynamic reception. SANS and SAXS allow us to investigate", "butter_fingers": " mafromolecules using anomauous small-angle X-ray sratterihg (ASAXS). In biology, osmotic pressure iw parupcularly important in regulatijg and mwdiauing physiological processes. Swspliny 'ressure measurgments probe the system in tfe large length scale range, thus provyding imflrmation on thg ovegajl tgvrnodynamic response. SANS and SZXS allmw us to invextigate", "random_deletion": "macromolecules using anomalous small-angle X-ray scattering (ASAXS). osmotic is particularly in regulating and measurements the system in large length scale thus providing information on the overall response. SANS and SAXS allow us to investigate", "change_char_case": " macromolecules using anomalOus small-anGle X-rAy sCatTeRing (aSAXs). In biology, osmoTIc prEssure is particularly imPortaNt IN regULaTing aNd mediaTInG PHysIoLoGicAl PRoCesseS. SwElling pRessure meaSurEmEnts probe the SYsTem in the laRge Length scale rAngE, thus pRoVidINg infOrmAtion On the oVErall tHermodynaMiC ResponSE. SANS anD saXs allOw us to investigate", "whitespace_perturbation": " macromolecules using anom alous smal l-ang leX-r ay  sca tter ing (ASAXS). I n  bio logy, osmotic pressure  is p ar t icul a rl y imp ortanti nr e gul at in g a nd me diati ngphysiol ogical pro ces se s. Swellingp re ssure meas ure ments probethe  syste mint he la rge  leng th sca l e rang e, thus p ro v idingi nformat i o non t he overall thermo d yn a mic response.SANS a nd SA X S  al low  us to inv es tigat e ", "underscore_trick": " macromolecules_using anomalous_small-angle X-ray scattering (ASAXS)._In biology,_osmotic_pressure is_particularly_important in regulating_and mediating physiological_processes. Swelling pressure measurements_probe the system_in_the large length scale range, thus providing information on the overall thermodynamic response. SANS_and_SAXS allow_us_to_investigate"}
{"text": " dioxin (tetrachlorodibenzo-p-dioxin, or TCDD). DDT is still used in about 25 countries for control of disease vectors, especially for malaria, under the assumption that there are no adverse human health effects. My recent findings are that higher maternal serum DDE level", "synonym_substitution": "dioxin (tetrachlorodibenzo - p - dioxin, or TCDD). DDT is still used in about 25 nation for restraint of disease vectors, especially for malaria, under the assumption that there be no adverse human health effects. My recent determination are that higher maternal serum DDE degree", "butter_fingers": " dilxin (tetrachlorodibenzo-p-aioxin, or TCDD). BET is vtill hsed in xbout 25 countries for control od distcse vectors, especialuy for maparia, uneer uhe assumption thef there are nk advzrwe human healtm effects. Mf recent finditgr cre that higher maternal serum DDE lqvel", "random_deletion": "dioxin (tetrachlorodibenzo-p-dioxin, or TCDD). DDT is still about countries for of disease vectors, assumption there are no human health effects. recent findings are that higher maternal DDE level", "change_char_case": " dioxin (tetrachlorodibenzo-p-Dioxin, or TCdD). DDT Is sTilL uSed iN aboUt 25 countries for COntrOl of disease vectors, espeCiallY fOR malARiA, undeR the assUMpTIOn tHaT tHerE aRE nO adveRse Human heAlth effectS. My ReCent findings ARe That higher MatErnal serum DDe leVel", "whitespace_perturbation": " dioxin (tetrachlorodibenz o-p-dioxin , orTCD D).  D DT i s st ill used in ab o ut 2 5 countries for contro l ofdi s ease ve ctors , espec i al l y  fo rma lar ia ,  u nderthe  assump tion thatthe re  are no adve r se  human hea lth  effects. My  re cent f in din g s are  th at hi gher m a ternal  serum DD El evel", "underscore_trick": " dioxin_(tetrachlorodibenzo-p-dioxin, or_TCDD). DDT is still_used in_about_25 countries_for_control of disease_vectors, especially for_malaria, under the assumption_that there are_no_adverse human health effects. My recent findings are that higher maternal serum DDE level"}
{"text": " probands participating in our genetic research protocol (http://ird.nichd.nih.gov), including several extended families to identify novel genes responsible for IGD. Data analysis is underway, and our findings are likely to yield important insights into additional pathways involved in the regulation of GnRH secretion. In one of our", "synonym_substitution": "probands participating in our genetic research protocol (http://ird.nichd.nih.gov), including respective extensive families to identify fresh genes creditworthy for IGD. Data analysis is afoot, and our findings are likely to yield significant insights into additional pathway involved in the regulation of GnRH secretion. In one of our", "butter_fingers": " prlbands participating in uur genetic resgaech prmtocol (http://ird.vichd.nih.gov), including severap wxteneed families to identiwy novel henes rewponwuble for IJS. Data analysjd is nnderway, and out findings ase likely to yheud important insights into additional pathwaus involved in tre rtgujatikn of GnRH secretion. In one of our", "random_deletion": "probands participating in our genetic research protocol several families to novel genes responsible underway, our findings are to yield important into additional pathways involved in the of GnRH secretion. In one of our", "change_char_case": " probands participating in ouR genetic reSearcH prOtoCoL (httP://ird.Nichd.nih.gov), incLUdinG several extended familiEs to iDeNTify NOvEl genEs respoNSiBLE foR IgD. datA aNAlYsis iS unDerway, aNd our findiNgs ArE likely to yieLD iMportant inSigHts into additIonAl pathWaYs iNVolveD in The reGulatiON of GnRh secretioN. IN One of oUR", "whitespace_perturbation": " probands participating in  our genet ic re sea rch  p roto col(http://ird.ni c hd.n ih.gov), including sev eralex t ende d  f amili es to i d en t i fyno ve l g en e srespo nsi ble for  IGD. Data  an al ysis is unde r wa y, and our  fi ndings are l ike ly toyi eld impor tan t ins ightsi nto ad ditionalpa t hwaysi nvolved i ntheregulation of GnR H  s e cretion. In on e of o ur ", "underscore_trick": " probands_participating in_our genetic research protocol_(http://ird.nichd.nih.gov), including_several_extended families_to_identify novel genes_responsible for IGD._Data analysis is underway,_and our findings_are_likely to yield important insights into additional pathways involved in the regulation of GnRH_secretion._In one_of_our"}
{"text": " such as customized antibody generation and the scaled production of purified biologics used as key assay reagents. DCTD envisions that the SAIC-F PD support program can direct such an expanded effort via directing the technical development and validation of additional assays under contracts to highly qualified vendors with the technical capabilities to follow the steps", "synonym_substitution": "such as customized antibody generation and the scaled production of purified biologics use as cardinal assay reagents. DCTD envisions that the SAIC - F PD support platform can lead such an expanded effort via address the technical exploitation and validation of extra assay under contracts to highly dependent vendors with the technical capabilities to succeed the steps", "butter_fingers": " sufh as customized antibodn generation and the sceled prkduction of purified biologics used es kwy asway reagents. DCTD envirions than the SAIX-F PV support program can divzct shgh an xxpanded effort via direcding the technhcxl development and validation of addieional ssdays under conjractx to gpgmly qualified vendors with the tschnican capabilitiex to follow the steps", "random_deletion": "such as customized antibody generation and the of biologics used key assay reagents. PD program can direct an expanded effort directing the technical development and validation additional assays under contracts to highly qualified vendors with the technical capabilities to the steps", "change_char_case": " such as customized antibody gEneration aNd the ScaLed PrOducTion Of purified biolOGics Used as key assay reagents. dCTD eNvISionS ThAt the sAIC-F PD SUpPORt pRoGrAm cAn DIrEct suCh aN expandEd effort viA diReCting the techNIcAl developmEnt And validatioN of AdditiOnAl aSSays uNdeR contRacts tO Highly Qualified VeNDors wiTH the tecHNIcAl caPabilities to folloW ThE Steps", "whitespace_perturbation": " such as customized antibo dy generat ion a ndthe  s cale d pr oduction of pu r ifie d biologics used as ke y ass ay reag e nt s. DC TD envi s io n s  th at  t heSA I C- F PDsup port pr ogram candir ec t such an ex p an ded effort  vi a directingthe  techn ic ald evelo pme nt an d vali d ationof additi on a l assa y s under c on trac ts to highly qual i fi e d vendors with  the t ec h ni c a l c apa bilities t ofollo w  the st e ps ", "underscore_trick": " such_as customized_antibody generation and the_scaled production_of_purified biologics_used_as key assay_reagents. DCTD envisions_that the SAIC-F PD_support program can_direct_such an expanded effort via directing the technical development and validation of additional assays_under_contracts to_highly_qualified_vendors with the technical capabilities_to follow the steps"}
{"text": " in the murine BM 5 months after transplantation were 36.0 3.9%. Quantitative PCR analysis of vector integrants within engrafted human cells indicated a single integration event occurred in most of long-term repopulating HSPCs. Flow cytometry-based lineage analysis of BM from mice transplanted with CD34+ cells trans", "synonym_substitution": "in the murine BM 5 months after transplantation were 36.0 3.9% . Quantitative PCR analysis of vector integrants within engrafted human cell indicate a single integration event occur in most of long - term repopulating HSPCs. run cytometry - based lineage psychoanalysis of BM from mouse transplanted with CD34 + cell trans", "butter_fingers": " in the murine BM 5 months anter transplantajiin werx 36.0 3.9%. Quahtitativd PCR analysis of vector intxgrabts wuthin engrafted human zells indpcated a wingow integratmkn evenb occhvred nn most of long-tgrm repopulading HSPCs. Flof zycometry-based lineage analysis of BM srom mive transplanted rith SD34+ cslls trans", "random_deletion": "in the murine BM 5 months after 36.0 Quantitative PCR of vector integrants a integration event occurred most of long-term HSPCs. Flow cytometry-based lineage analysis of from mice transplanted with CD34+ cells trans", "change_char_case": " in the murine BM 5 months after tRansplantaTion wEre 36.0 3.9%. quaNtItatIve PcR analysis of veCTor iNtegrants within engraftEd humAn CElls INdIcateD a singlE InTEGraTiOn EveNt OCcUrred In mOst of loNg-term repoPulAtIng HSPCs. Flow CYtOmetry-baseD liNeage analysiS of bM from MiCe tRAnsplAntEd witH CD34+ celLS trans", "whitespace_perturbation": " in the murine BM 5 months  after tra nspla nta tio nwere  36. 0 3.9%. Quanti t ativ e PCR analysis of vect or in te g rant s  w ithin  engraf t ed h uma nce lls  i n di cated  asingleintegratio n e ve nt occurredi nmost of lo ng- term repopul ati ng HSP Cs . F l ow cy tom etry- basedl ineage  analysis  o f  BM fr o m micet r an spla nted with CD34+ c e ll s  trans", "underscore_trick": " in_the murine_BM 5 months after_transplantation were_36.0_3.9%. Quantitative_PCR_analysis of vector_integrants within engrafted_human cells indicated a_single integration event_occurred_in most of long-term repopulating HSPCs. Flow cytometry-based lineage analysis of BM from mice_transplanted_with CD34+_cells_trans"}
{"text": " projects relating to Vpu and its interaction with the host restriction factor BST-2 as well as the structural characterization of BST-2. We also completed our study on the characterization of SAMHD1 splice variants and we initiated a new project on the characterization of the functional significance of SAMHD1 phosphorylation for its antiviral", "synonym_substitution": "projects relating to Vpu and its interaction with the host restriction agent BST-2 equally well as the structural characterization of BST-2. We besides completed our sketch on the characterization of SAMHD1 lap joint variants and we initiated a new undertaking on the word picture of the functional meaning of SAMHD1 phosphorylation for its antiviral", "butter_fingers": " prljects relating to Vpu akd its interaction with the hkst restfiction factor BST-2 as well ad rhe suguctural characterizagion of BDT-2. We alwo cinpleted ouc study on the gharaetxrization of SAKHD1 splice variants and fe iuitiated a new project on the characeerizatooj of the functyonak sighpflcance of SAMHD1 phosphorylation ror its antiviral", "random_deletion": "projects relating to Vpu and its interaction host factor BST-2 well as the also our study on characterization of SAMHD1 variants and we initiated a new on the characterization of the functional significance of SAMHD1 phosphorylation for its antiviral", "change_char_case": " projects relating to Vpu and iTs interactIon wiTh tHe hOsT resTricTion factor BST-2 aS Well As the structural charactErizaTiON of Bst-2. WE also CompletED oUR StuDy On The ChARaCteriZatIon of SAmHD1 splice vAriAnTs and we initiATeD a new projeCt oN the characteRizAtion oF tHe fUNctioNal SigniFicancE Of SAMHd1 phosphorYlATion foR Its antiVIRaL", "whitespace_perturbation": " projects relating to Vpuand its in terac tio n w it h th e ho st restriction fact or BST-2 as well as th e str uc t ural ch aract erizati o no f  BS T- 2.  We  a l so  comp let ed ourstudy on t hech aracterizati o nof SAMHD1spl ice variants  an d we i ni tia t ed anew  proj ect on the ch aracteriz at i on oft he func t i on al s ignificance of SA M HD 1  phosphorylati on for  i t sa n tiv ira l", "underscore_trick": " projects_relating to_Vpu and its interaction_with the_host_restriction factor_BST-2_as well as_the structural characterization_of BST-2. We also_completed our study_on_the characterization of SAMHD1 splice variants and we initiated a new project on the_characterization_of the_functional_significance_of SAMHD1 phosphorylation for its_antiviral"}
{"text": " restored. Moreover, addition of this transgene to a wild-type strain increased sensitivity to halothane, demonstrating that Ryr is a limiting factor for this drug. Of particular importance is our recent discovery that, using the GAL4/UAS system, expression of a Ryr cDNA in the nervous system is sufficient", "synonym_substitution": "restored. Moreover, addition of this transgene to a wild - character breed increased sensitivity to halothane, demonstrating that Ryr is a specify divisor for this drug. Of particular importance is our recent discovery that, use the GAL4 / UAS organization, expression of a Ryr complementary dna in the skittish system is sufficient", "butter_fingers": " redtored. Moreover, addition of this transggnw to a wild-tgpe strakn increased sensitivity to ialorhane, demonstrating that Ryf is a liliting fqctoc for this drug. Of partigblar jlporcaice is our recekt discoverf that, using tve GCL4/UAS system, expression of a Ryr cDNW in thr jervous system is xtffidpekt", "random_deletion": "restored. Moreover, addition of this transgene to strain sensitivity to demonstrating that Ryr this Of particular importance our recent discovery using the GAL4/UAS system, expression of Ryr cDNA in the nervous system is sufficient", "change_char_case": " restored. Moreover, addition oF this transGene tO a wIld-TyPe stRain Increased sensiTIvitY to halothane, demonstratIng thAt rYr is A LiMitinG factor FOr THIs dRuG. OF paRtICuLar imPorTance is Our recent dIscOvEry that, using THe gAL4/UAS systEm, eXpression of a ryr CDNA in ThE neRVous sYstEm is sUfficiENt", "whitespace_perturbation": " restored. Moreover, addit ion of thi s tra nsg ene  t o awild -type strain i n crea sed sensitivity to hal othan e, demo n st ratin g thatR yr i s a  l im iti ng fa ctorfor  this d rug. Of pa rti cu lar importan c eis our rec ent  discovery t hat , usin gthe GAL4/ UAS  syst em, ex p ressio n of a Ry rc DNA in the ner v o us  sys tem is sufficient ", "underscore_trick": " restored._Moreover, addition_of this transgene to_a wild-type_strain_increased sensitivity_to_halothane, demonstrating that_Ryr is a_limiting factor for this_drug. Of particular_importance_is our recent discovery that, using the GAL4/UAS system, expression of a Ryr cDNA_in_the nervous_system_is_sufficient"}
{"text": "audi. After 7 days of culture in the presence of various concentrations of a test agent, the cells were harvested and subjected to determination of cell growth, cell viability and DNA extraction (for real-time mtDNA-PCR). In the case of ETV, a sharp decline in cell viability and growth was seen at 10 microM", "synonym_substitution": "audi. After 7 days of culture in the presence of various concentration of a trial agent, the cells were harvested and subject to determination of cell emergence, cellular telephone viability and DNA extraction (for real - time mtDNA - PCR). In the case of ETV, a sharp descent in cell viability and growth was see at 10 microM", "butter_fingers": "audl. After 7 days of culture in the presencg if varmous cohcentratkons of a test agent, the celps were harvested and subjectdd to detvrminatiob of xell growti, cell vlcbilifn and VNA extraction (nor real-tima mtDNA-PCR). In dhd ease of ETV, a sharp decline in cell diabiliyy and growth waf setn wt 10 jpcvoM", "random_deletion": "audi. After 7 days of culture in of concentrations of test agent, the to of cell growth, viability and DNA (for real-time mtDNA-PCR). In the case ETV, a sharp decline in cell viability and growth was seen at 10", "change_char_case": "audi. After 7 days of culture in tHe presence Of varIouS coNcEntrAtioNs of a test agent, THe ceLls were harvested and subJecteD tO DeteRMiNatioN of cell GRoWTH, ceLl ViAbiLiTY aNd DNA ExtRaction (For real-timE mtdNa-PCR). In the casE Of eTV, a sharp dEclIne in cell viaBilIty and GrOwtH Was seEn aT 10 micrOM", "whitespace_perturbation": "audi. After 7 days of cult ure in the  pres enc e o fvari ousconcentrations of a  test agent, the cells  were  h a rves t ed  andsubject e dt o  de te rm ina ti o nof ce llgrowth,  cell viab ili ty  and DNA ext r ac tion (forrea l-time mtDNA -PC R). In  t hec ase o f E TV, a  sharp declin e in cell  v i abilit y  and gr o w th  was  seen at 10 micro M ", "underscore_trick": "audi. After_7 days_of culture in the_presence of_various_concentrations of_a_test agent, the_cells were harvested_and subjected to determination_of cell growth,_cell_viability and DNA extraction (for real-time mtDNA-PCR). In the case of ETV, a sharp_decline_in cell_viability_and_growth was seen at 10_microM"}
{"text": " rAAV-copGFP episomes or random transgene integration events. In summary, HITI-based transgene knock-in provides an effective alternative to HDR-mediated donor template recombination in human CD34+ HPSCs. Objective 3: Develop a targeted, non-genotoxic conditioning regimen based on anti-c", "synonym_substitution": "rAAV - copGFP episomes or random transgene integration events. In summary, HITI - based transgene knock - in provides an effective option to HDR - intercede donor template recombination in human CD34 + HPSCs. Objective 3: Develop a targeted, non - genotoxic conditioning regimen free-base on anti - speed of light", "butter_fingers": " rAWV-copGFP episomes or ranaom transgene iuregratmon evehts. In sjmmary, HITI-based transgene kiock-un privides an effective algernative to HDR-mwdiaued donor templatx recombluatioh in kunan CD34+ HPSCs. Onjective 3: Davelop a targedea, uon-genotoxic conditioning regimen bafed on snhi-c", "random_deletion": "rAAV-copGFP episomes or random transgene integration events. HITI-based knock-in provides effective alternative to human HPSCs. Objective 3: a targeted, non-genotoxic regimen based on anti-c", "change_char_case": " rAAV-copGFP episomes or randoM transgene IntegRatIon EvEnts. in suMmary, HITI-based TRansGene knock-in provides an eFfectIvE AlteRNaTive tO HDR-medIAtED DonOr TeMplAtE ReCombiNatIon in huMan CD34+ HPSCs. objEcTive 3: Develop a TArGeted, non-geNotOxic conditioNinG regimEn BasED on anTi-c", "whitespace_perturbation": " rAAV-copGFP episomes or r andom tran sgene  in teg ra tion  eve nts. In summar y , HI TI-based transgene kno ck-in  p r ovid e san ef fective al t e rna ti ve  to  H D R- media ted  donortemplate r eco mb ination in h u ma n CD34+ HP SCs . Objective3:Develo pa t a rgete d,non-g enotox i c cond itioningre g imen b a sed ona n ti -c", "underscore_trick": " rAAV-copGFP_episomes or_random transgene integration events._In summary,_HITI-based_transgene knock-in_provides_an effective alternative_to HDR-mediated donor_template recombination in human_CD34+ HPSCs. Objective_3:_Develop a targeted, non-genotoxic conditioning regimen based on anti-c"}
{"text": " 2016). Neurocognitive Effects of Sex Hormone Deficiency at or Before Puberty There is little existing evidence for the neurocognitive effects of delayed puberty. We have performed neurocognitive testing and structural and functional MRI on subjects with IGD, compared with healthy controls matched for age, sex, and race", "synonym_substitution": "2016). Neurocognitive Effects of Sex Hormone Deficiency at or Before Puberty There is little existing evidence for the neurocognitive effect of stay puberty. We have performed neurocognitive testing and structural and running MRI on subjects with IGD, compared with healthy control matched for age, sexual activity, and raceway", "butter_fingers": " 2016). Nfurocognitive Effects of Sex Hormone Deyuciencb at or Before Ouberty There is little exisving evidtuce for the neurocogvitive efvects of deleyed puberty. We izve pernjrmes neuxorognitive testikg and struwtural and funwtkoual MRI on subjects with IGD, compareq with newlthy controls matbhqd fkg cge, sex, and race", "random_deletion": "2016). Neurocognitive Effects of Sex Hormone Deficiency Before There is existing evidence for puberty. have performed neurocognitive and structural and MRI on subjects with IGD, compared healthy controls matched for age, sex, and race", "change_char_case": " 2016). Neurocognitive Effects of SeX Hormone DeFicieNcy At oR BEforE PubErty There is litTLe exIsting evidence for the neUrocoGnITive EFfEcts oF delayeD PuBERty. we HaVe pErFOrMed neUroCognitiVe testing aNd sTrUctural and fuNCtIonal MRI on SubJects with IGD, ComPared wItH heALthy cOntRols mAtched FOr age, sEx, and race", "whitespace_perturbation": " 2016). Neurocognitive Eff ects of Se x Hor mon e D ef icie ncyat or Before P u bert y There is little exis tingev i denc e  f or th e neuro c og n i tiv eef fec ts of  dela yed  pubert y. We have  pe rf ormed neuroc o gn itive test ing  and structu ral  and f un cti o nal M RIon su bjects with I GD, compa re d  withh ealthyc o nt rols  matched for age, se x , and race", "underscore_trick": " 2016)._Neurocognitive Effects_of Sex Hormone Deficiency_at or_Before_Puberty There_is_little existing evidence_for the neurocognitive_effects of delayed puberty._We have performed_neurocognitive_testing and structural and functional MRI on subjects with IGD, compared with healthy controls_matched_for age,_sex,_and_race"}
{"text": " imaging the plasma membrane of human cells with both fluorescence microscopy (TIRF) and transmission electron microscopy (TEM) of platinum replicas. These studies are allowing us to build structural models for how single organelles are organized and how these complexes regulate exocytosis, a central process for commination among cells and tissues in the", "synonym_substitution": "imaging the plasma membrane of human cells with both fluorescence microscopy (TIRF) and transmission electron microscopy (TEM) of platinum replicas. These studies are allow us to build up structural models for how single organelle are organized and how these complexes regulate exocytosis, a cardinal summons for commination among cells and tissue in the", "butter_fingers": " imwging the plasma membrant of human cells cuth bovh fluodescence microscopy (TIRF) and transmidsuon eoectron microscopy (TEM) of platijum replucas. Rhese studmss are allowihn us co build structutal models fmr how single mreauelles are organized and how these cjmplexex gegulate exocyjosis, w cehnrcl process for commination amonf cells and tissues on the", "random_deletion": "imaging the plasma membrane of human cells fluorescence (TIRF) and electron microscopy (TEM) are us to build models for how organelles are organized and how these regulate exocytosis, a central process for commination among cells and tissues in the", "change_char_case": " imaging the plasma membrane oF human cellS with BotH flUoRescEnce Microscopy (TIRF) ANd trAnsmission electron micrOscopY (Tem) of pLAtInum rEplicas. tHeSE StuDiEs Are AlLOwIng us To bUild strUctural modEls FoR how single orGAnElles are orGanIzed and how thEse CompleXeS reGUlate ExoCytosIs, a cenTRal proCess for coMmINation AMong celLS AnD tisSues in the", "whitespace_perturbation": " imaging the plasma membra ne of huma n cel lswit hboth  flu orescence micr o scop y (TIRF) and transmiss ion e le c tron mi crosc opy (TE M )o f  pl at in umre p li cas.The se stud ies are al low in g us to buil d  s tructuralmod els for howsin gle or ga nel l es ar e o rgani zed an d  how t hese comp le x es reg u late ex o c yt osis , a central proce s sf or commination  among  c e ll s and  ti ssues in t he ", "underscore_trick": " imaging_the plasma_membrane of human cells_with both_fluorescence_microscopy (TIRF)_and_transmission electron microscopy_(TEM) of platinum_replicas. These studies are_allowing us to_build_structural models for how single organelles are organized and how these complexes regulate exocytosis,_a_central process_for_commination_among cells and tissues in_the"}
{"text": " noted reduced Vif expression in CBF knockdown cells while others saw no significant impact of CBF on Vif stability. Indeed, we confirmed that CBF increases Vif steady-state levels. This effect was seen for Vif expressed from a full-length molecular clone of HIV-1 as well as for Vif", "synonym_substitution": "noted reduced Vif expression in CBF knockdown cells while others see no meaning impact of CBF on Vif stability. Indeed, we confirm that CBF increase Vif steady - state level. This impression was seen for Vif express from a full - length molecular knockoff of HIV-1 as well as for Vif", "butter_fingers": " nohed reduced Vif expressiun in CBF knockbiwn cenls whjle othefs saw no significant impact od CBF on Vif stability. Indedd, we convirmed tyat RBF increases Vih steady-state mcvels. Vhis effect was seen for Eif expressed xrum a full-length molecular clone of HID-1 as wekl as for Vif", "random_deletion": "noted reduced Vif expression in CBF knockdown others no significant of CBF on that increases Vif steady-state This effect was for Vif expressed from a full-length clone of HIV-1 as well as for Vif", "change_char_case": " noted reduced Vif expression In CBF knockDown cEllS whIlE othErs sAw no significanT ImpaCt of CBF on Vif stability. INdeed, We COnfiRMeD that cBF incrEAsES vif StEaDy-sTaTE lEvels. thiS effect Was seen for vif ExPressed from a FUlL-length molEcuLar clone of HIv-1 as Well as FoR ViF", "whitespace_perturbation": " noted reduced Vif express ion in CBF  knoc kdo wnce llswhil e others saw n o  sig nificant impact of CBF  on V if stab i li ty. I ndeed,w ec o nfi rm ed  th at CB F inc rea ses Vif  steady-st ate  l evels. Thise ff ect was se enfor Vif expr ess ed fro ma f u ll-le ngt h mol ecular cloneof HIV-1as well a s  for Vi f ", "underscore_trick": " noted_reduced Vif_expression in CBF knockdown_cells while_others_saw no_significant_impact of CBF_on Vif stability._Indeed, we confirmed that_CBF increases Vif_steady-state_levels. This effect was seen for Vif expressed from a full-length molecular clone of_HIV-1_as well_as_for_Vif"}
{"text": "ages for virus by infectious virus assay and RT-PCR, by direct assay for infectious virus in harvested tissue, by immunohistochemical analysis of harvested tissue, and by profiling challenge-induced pulmonary host gene expression. Replacement of the polybasic cleavage site of the HA insert with the monobasic site from a low pathogenicity strain", "synonym_substitution": "ages for virus by infectious virus assay and RT - PCR, by direct assay for infectious virus in harvested tissue, by immunohistochemical analysis of harvested tissue, and by profile challenge - induce pulmonary host gene expression. substitution of the polybasic cleavage site of the HA insert with the monobasic site from a broken pathogenicity form", "butter_fingers": "aged for virus by infectiour virus assay aue RT-PCC, by didect assxy for infectious virus in hervewted upssue, by immunohistocfemical ajalysis if hervested tissue, ehd by pvjfiljkg chcloenge-induced polmonary hosd gene expresshov. Xeplacement of the polybasic cleavagq site pf the HA insert witn the monobasic site from a low pathogehicity vtrain", "random_deletion": "ages for virus by infectious virus assay by assay for virus in harvested harvested and by profiling pulmonary host gene Replacement of the polybasic cleavage site the HA insert with the monobasic site from a low pathogenicity strain", "change_char_case": "ages for virus by infectious vIrus assay aNd RT-PcR, bY diReCt asSay fOr infectious viRUs in Harvested tissue, by immunOhistOcHEmicAL aNalysIs of harVEsTED tiSsUe, And By PRoFilinG chAllenge-Induced pulMonArY host gene expREsSion. ReplacEmeNt of the polybAsiC cleavAgE siTE of thE HA InserT with tHE monobAsic site fRoM A low paTHogenicITY sTraiN", "whitespace_perturbation": "ages for virus by infectio us virus a ssayand  RT -P CR,by d irect assay fo r  inf ectious virus in harve stedti s sue, by  immu nohisto c he m i cal  a na lys is of  harv est ed tiss ue, and by  pr of iling challe n ge -induced p ulm onary host g ene  expre ss ion .  Repl ace mentof the polyba sic cleav ag e  siteo f the H A in sert  with the monobas i cs ite from a low  patho ge n ic i t y s tra in", "underscore_trick": "ages for_virus by_infectious virus assay and_RT-PCR, by_direct_assay for_infectious_virus in harvested_tissue, by immunohistochemical_analysis of harvested tissue,_and by profiling_challenge-induced_pulmonary host gene expression. Replacement of the polybasic cleavage site of the HA insert_with_the monobasic_site_from_a low pathogenicity strain"}
{"text": " and very old adults. The Specific Aims of Phase II of ACTIVE are: 1) to determine whether the cognitive interventions (as initial treatment or as a consequence of repeated boosters) have long-term protective effects on functional outcomes; 2) to document any delayed transfer of the cognitive training to secondary outcomes; and", "synonym_substitution": "and very old adults. The Specific Aims of Phase II of ACTIVE are: 1) to determine whether the cognitive interventions (as initial discussion or as a consequence of recur boosters) have retentive - terminus protective effects on functional consequence; 2) to document any check transfer of the cognitive education to junior-grade outcomes; and", "butter_fingers": " anf very old adults. The Sptcific Aims of Phcwe II mf ACTJVE are: 1) to determine whether the cojnituve ibterventions (as initiau treatmejt or as a cibsequence of repeabzd bokdterv) have long-term protectiva effects on fgnztnonal outcomes; 2) to document any delared tramsver of the coggitine trajning to secondary outcomes; and", "random_deletion": "and very old adults. The Specific Aims II ACTIVE are: to determine whether treatment as a consequence repeated boosters) have protective effects on functional outcomes; 2) document any delayed transfer of the cognitive training to secondary outcomes; and", "change_char_case": " and very old adults. The SpecifIc Aims of PhAse II Of AcTIvE Are: 1) tO detErmine whether tHE cogNitive interventions (as iNitiaL tREatmENt Or as a ConsequENcE OF rePeAtEd bOoSTeRs) havE loNg-term pRotective eFfeCtS on functionaL OuTcomes; 2) to doCumEnt any delayeD trAnsfer Of The COgnitIve TrainIng to sECondarY outcomes; AnD", "whitespace_perturbation": " and very old adults. TheSpecific A ims o f P has eII o f AC TIVE are: 1) t o  det ermine whether the cog nitiv ei nter v en tions  (as in i ti a l  tr ea tm ent  o r  a s a c ons equence  of repeat edbo osters) have lo ng-term pr ote ctive effect s o n func ti ona l  outc ome s; 2)  to do c umentany delay ed transf e r of th e co gnit ive training to s e co n dary outcomes;  and", "underscore_trick": " and_very old_adults. The Specific Aims_of Phase_II_of ACTIVE_are:_1) to determine_whether the cognitive_interventions (as initial treatment_or as a_consequence_of repeated boosters) have long-term protective effects on functional outcomes; 2) to document any_delayed_transfer of_the_cognitive_training to secondary outcomes; and"}
{"text": " of the avian Newcastle disease virus (NDV) as a human vaccine vector. NDV is antigenically distinct from common human pathogens and thus should not be affected by pre-existing immunity. In addition, there is anecdotal evidence that NDV is highly restricted in humans and does not cause significant disease. We confirmed", "synonym_substitution": "of the avian Newcastle disease virus (NDV) as a human vaccine vector. NDV is antigenically distinct from common human pathogens and thus should not be involve by pre - existent immunity. In addition, there be anecdotic evidence that NDV is highly restricted in humans and does not cause meaning disease. We confirm", "butter_fingers": " of the avian Newcastle distase virus (NDV) as a humai vaccihe vectof. NDV is antigenically distiict drom xommon human pathogens and thus should bot ue affected by pcs-existiky immhkity. Nn addition, therg is anecdotdl evidence thdt NBV is highly restricted in humans anq does moh cause signifycanu dyseaav. Ce confirmed", "random_deletion": "of the avian Newcastle disease virus (NDV) human vector. NDV antigenically distinct from should be affected by immunity. In addition, is anecdotal evidence that NDV is restricted in humans and does not cause significant disease. We confirmed", "change_char_case": " of the avian Newcastle diseasE virus (NDV) aS a humAn vAccInE vecTor. NdV is antigenicaLLy diStinct from common human pAthogEnS And tHUs ShoulD not be aFFeCTEd bY pRe-ExiStINg ImmunIty. in additIon, there is AneCdOtal evidence THaT NDV is highLy rEstricted in hUmaNs and dOeS noT Cause SigNificAnt disEAse. We cOnfirmed", "whitespace_perturbation": " of the avian Newcastle di sease viru s (ND V)asahuma n va ccine vector.N DV i s antigenically distin ct fr om comm o nhuman  pathog e ns a ndth us  sh ou l dnot b e a ffected  by pre-ex ist in g immunity.I naddition,the re is anecdo tal  evide nc e t h at ND V i s hig hly re s tricte d in huma ns and do e s not c a u se  sig nificant disease. We confirmed", "underscore_trick": " of_the avian_Newcastle disease virus (NDV)_as a_human_vaccine vector._NDV_is antigenically distinct_from common human_pathogens and thus should_not be affected_by_pre-existing immunity. In addition, there is anecdotal evidence that NDV is highly restricted in_humans_and does_not_cause_significant disease. We confirmed"}
{"text": "uropeptides oxytocin and vasopressin act to induce synaptic potentiation in CA2 pyramidal neurons in a way that closely resembled typical LTP. The vasopressin 1b receptor (avpr1b) is highly enriched in CA2 neurons over all other parts of the brain, suggesting that CA", "synonym_substitution": "uropeptides oxytocin and vasopressin act to induce synaptic potentiation in CA2 pyramidal neurons in a way that closely resembled distinctive LTP. The vasopressin 1b sense organ (avpr1b) is highly enrich in CA2 neurons over all early parts of the genius, suggesting that CA", "butter_fingers": "urooeptides oxytocin and varopressin act to inducx synapfic potevtiation in CA2 pyramidal neucons in a way that closely reseobled typpcal LTP. Rhe tasopressin 1b rersptor (ay'r1b) ia higklb enriched in CS2 neurons mver all other pxrcs of the brain, suggesting that CA", "random_deletion": "uropeptides oxytocin and vasopressin act to induce in pyramidal neurons a way that vasopressin receptor (avpr1b) is enriched in CA2 over all other parts of the suggesting that CA", "change_char_case": "uropeptides oxytocin and vasOpressin acT to inDucE syNaPtic PoteNtiation in CA2 pyRAmidAl neurons in a way that cloSely rEsEMbleD TyPical lTP. The vASoPREssIn 1B rEcePtOR (aVpr1b) iS hiGhly enrIched in CA2 nEurOnS over all otheR PaRts of the brAin, Suggesting thAt Ca", "whitespace_perturbation": "uropeptides oxytocin and v asopressin  acttoind uc e sy napt ic potentiatio n  inCA2 pyramidal neuronsin awa y  tha t  c losel y resem b le d typ ic al  LT P. Th e vas opr essin 1 b receptor  (a vp r1b) is high l yenriched i n C A2 neurons o ver  all o th erp artsofthe b rain,s uggest ing thatCA ", "underscore_trick": "uropeptides oxytocin_and vasopressin_act to induce synaptic_potentiation in_CA2_pyramidal neurons_in_a way that_closely resembled typical_LTP. The vasopressin 1b_receptor (avpr1b) is_highly_enriched in CA2 neurons over all other parts of the brain, suggesting that CA"}
{"text": " other critical endocytic components at the nanoscale with this method to develop a global map of the proteins involved in endocytosis. These studies are allowing us to build structural models for how proteins are organized at single organelles to regulate endocytosis, a central process for all living cells. Aim 3 My lab's major focus", "synonym_substitution": "other critical endocytic components at the nanoscale with this method to develop a ball-shaped function of the protein involved in endocytosis. These studies are allowing us to build up structural models for how protein are organized at single organelles to determine endocytosis, a central process for all exist cells. Aim 3 My lab's major stress", "butter_fingers": " otjer critical endocytic cumponents at thg banoscele witg this mdthod to develop a global ma' of the kgoteins involved in evdocytosid. These wtudmes are allowing us to bmnld sfvuctuxao models for hpw proteinv are organizeg xt single organelles to regulate endosytosis, a central procefs fpw alm living cells. Aim 3 My lab's major rocus", "random_deletion": "other critical endocytic components at the nanoscale method develop a map of the studies allowing us to structural models for proteins are organized at single organelles regulate endocytosis, a central process for all living cells. Aim 3 My lab's focus", "change_char_case": " other critical endocytic comPonents at tHe nanOscAle WiTh thIs meThod to develop a GLobaL map of the proteins involVed in EnDOcytOSiS. ThesE studieS ArE ALloWiNg Us tO bUIlD struCtuRal modeLs for how prOteInS are organizeD At Single orgaNelLes to regulatE enDocytoSiS, a cENtral ProCess fOr all lIVing ceLls. Aim 3 My lAb'S Major fOCus", "whitespace_perturbation": " other critical endocyticcomponents  at t henan os cale  wit h this methodt o de velop a global map ofthe p ro t eins in volve d in en d oc y t osi s.  T hes es tu diesare  allowi ng us to b uil dstructural m o de ls for how  pr oteins are o rga nizedat  si n gle o rga nelle s to r e gulate  endocyto si s , a ce n tral pr o c es s fo r all living cell s .A im 3 My lab'smajorfo c us ", "underscore_trick": " other_critical endocytic_components at the nanoscale_with this_method_to develop_a_global map of_the proteins involved_in endocytosis. These studies_are allowing us_to_build structural models for how proteins are organized at single organelles to regulate endocytosis,_a_central process_for_all_living cells. Aim 3 My_lab's major focus"}
{"text": " Biol Chem. 279, 24372, 2003);and e) showed that cholesterol was absolutely required for chemotaxis and associated spatial polarization of chemotactic mediators, but not for endocytosis of agonist-occupied receptors and associated signaling (J Biomed Sci 15, 441, 2008). Human chemokine and chemokine receptor dysfunction are associated with numerous", "synonym_substitution": "Biol Chem. 279, 24372, 2003);and e) showed that cholesterol was absolutely required for chemotaxis and associated spatial polarization of chemotactic mediator, but not for endocytosis of protagonist - fill receptors and consociate bespeak (J Biomed Sci 15, 441, 2008). Human chemokine and chemokine receptor dysfunction are associated with numerous", "butter_fingers": " Bill Chem. 279, 24372, 2003);and e) showed tmat cholesterol cqs absmlutelg requirdd for chemotaxis and associeted spatual polarization of chdmotactic mediatoes, bnt not for endocbfosis on agohlst-oceu'ied receptors snd associdted signaling (J Bnomed Sci 15, 441, 2008). Human chemokine and cheiokine tefeptor dysfuncjion swe aasociated with numerous", "random_deletion": "Biol Chem. 279, 24372, 2003);and e) showed was required for and associated spatial not endocytosis of agonist-occupied and associated signaling Biomed Sci 15, 441, 2008). Human and chemokine receptor dysfunction are associated with numerous", "change_char_case": " Biol Chem. 279, 24372, 2003);and e) showed that choLesterol waS absoLutEly ReQuirEd foR chemotaxis and ASsocIated spatial polarizatiOn of cHeMOtacTIc MediaTors, but NOt FOR enDoCyTosIs OF aGonisT-ocCupied rEceptors anD asSoCiated signalINg (j Biomed Sci 15, 441, 2008). humAn chemokine aNd cHemokiNe RecEPtor dYsfUnctiOn are aSSociatEd with numErOUs", "whitespace_perturbation": " Biol Chem. 279, 24372, 20 03);and e)  show edtha tchol este rol was absolu t elyrequired for chemotaxi s and  a s soci a te d spa tial po l ar i z ati on  o f c he m ot actic  me diators , but notfor  e ndocytosis o f  a gonist-occ upi ed receptors  an d asso ci ate d  sign ali ng (J  Biome d  Sci 1 5, 441, 2 00 8 ). Hum a n chemo k i ne  and  chemokine recept o rd ysfunction are  assoc ia t ed w ith  nu merous", "underscore_trick": " Biol_Chem. 279,_24372, 2003);and e) showed_that cholesterol_was_absolutely required_for_chemotaxis and associated_spatial polarization of_chemotactic mediators, but not_for endocytosis of_agonist-occupied_receptors and associated signaling (J Biomed Sci 15, 441, 2008). Human chemokine and chemokine_receptor_dysfunction are_associated_with_numerous"}
{"text": " homolog of BAG3, starvin (stv). In recent work that used a panel of isoform-specific antibodies, they discovered expression of the protein in the CNS and at the neuromuscular junction (NMJ). Loss of stv function results in large NMJ synaptic boutons that are clumped together, while", "synonym_substitution": "homolog of BAG3, starvin (stv). In recent work that used a panel of isoform - specific antibody, they discover expression of the protein in the CNS and at the neuromuscular articulation (NMJ). Loss of stv routine results in large NMJ synaptic boutons that are clop together, while", "butter_fingers": " hololog of BAG3, starvin (stv). In recent work that uved a lanel of isoform-specific antibodies, vhey discivered expression of tfe proteij in the CNS qnd at the neuromuscular munctnoi (NMJ). Loss of sjv function sesults in larce NLJ synaptic boutons that are clumpeq togetneg, while", "random_deletion": "homolog of BAG3, starvin (stv). In recent used panel of antibodies, they discovered the and at the junction (NMJ). Loss stv function results in large NMJ boutons that are clumped together, while", "change_char_case": " homolog of BAG3, starvin (stv). In rEcent work tHat usEd a PanEl Of isOforM-specific antibODies, They discovered expressiOn of tHe PRoteIN iN the CnS and at THe NEUroMuScUlaR jUNcTion (NmJ). LOss of stV function rEsuLtS in large NMJ sYNaPtic boutonS thAt are clumped TogEther, wHiLe", "whitespace_perturbation": " homolog of BAG3, starvin(stv). Inrecen t w ork  t hatused  a panel of is o form -specific antibodies,theydi s cove r ed  expr essiono ft h e p ro te inin th e CNS  an d at th e neuromus cul ar  junction (N M J) . Loss ofstv  function re sul ts inla rge NMJ s yna pticbouton s  thatare clump ed togeth e r, whil e ", "underscore_trick": " homolog_of BAG3,_starvin (stv). In recent_work that_used_a panel_of_isoform-specific antibodies, they_discovered expression of_the protein in the_CNS and at_the_neuromuscular junction (NMJ). Loss of stv function results in large NMJ synaptic boutons that_are_clumped together,_while"}
{"text": " by day 7 of administration. The greatest magnitude of viremia reduction with CMCP was -1.1 log10 copies/ml (average of -1.2 and -1.0 log 10). Over the 14-day period of administration, the viremia reduction in CMCP-receiving mice was", "synonym_substitution": "by day 7 of administration. The greatest magnitude of viremia decrease with CMCP was -1.1 log10 copy / ml (average of -1.2 and -1.0 log 10). Over the 14 - sidereal day period of government, the viremia reduction in CMCP - receiving mouse was", "butter_fingers": " by day 7 of administration. Uhe greatest magnnrude oh viremja reducgion with CMCP was -1.1 log10 copixs/ml (averqge of -1.2 and -1.0 log 10). Over the 14-day ieriod of admmnistration, the tjremia vzductjln iu RMCP-receiving mlce was", "random_deletion": "by day 7 of administration. The greatest viremia with CMCP -1.1 log10 copies/ml log Over the 14-day of administration, the reduction in CMCP-receiving mice was", "change_char_case": " by day 7 of administration. The gReatest magNitudE of VirEmIa reDuctIon with CMCP was -1.1 LOg10 coPies/ml (average of -1.2 and -1.0 log 10). OVer thE 14-dAY perIOd Of admInistraTIoN, THe vIrEmIa rEdUCtIon in cMCp-receivIng mice was", "whitespace_perturbation": " by day 7 of administratio n. The gre atest  ma gni tu de o f vi remia reductio n  wit h CMCP was -1.1 log10copie s/ m l (a v er age o f -1.2a nd - 1.0  l og  10 ). Ov er th e 1 4-day p eriod of a dmi ni stration, th e  v iremia red uct ion in CMCP- rec eiving  m ice was", "underscore_trick": " by_day 7_of administration. The greatest_magnitude of_viremia_reduction with_CMCP_was -1.1 log10_copies/ml (average of_-1.2 and -1.0 log_10). Over the_14-day_period of administration, the viremia reduction in CMCP-receiving mice was"}
{"text": " to understand better the roles of MC3R in peripheral metabolism. We have previously found that leptin is an important predictor of weight gain in children and identified children with hyperleptinemia and leptin receptor mutations. We have also found hyperleptinemia out of proportion with body fat mass in children with psychological loss of control (", "synonym_substitution": "to understand better the roles of MC3R in peripheral metabolism. We have previously find oneself that leptin is an authoritative predictor of weight gain in child and identified children with hyperleptinemia and leptin sense organ mutations. We have also found hyperleptinemia out of symmetry with soundbox fat bulk in children with psychological loss of restraint (", "butter_fingers": " to understand better the rules of MC3R in keeipherel metagolism. Wd have previously found that lwptin is an important prediztor of wvight gaib in xhildren ais identlyied dmildrzn with hyperlepjinemia and neptin receptos oucations. We have also found hyperleptynemia puh of proportiog wiuh fody fat mass in children with psycholkgical noss of contrpl (", "random_deletion": "to understand better the roles of MC3R metabolism. have previously that leptin is gain children and identified with hyperleptinemia and receptor mutations. We have also found out of proportion with body fat mass in children with psychological loss of (", "change_char_case": " to understand better the roleS of MC3R in peRipheRal MetAbOlisM. We hAve previously fOUnd tHat leptin is an important PrediCtOR of wEIgHt gaiN in chilDReN ANd iDeNtIfiEd CHiLdren WitH hyperlEptinemia aNd lEpTin receptor mUTaTions. We havE alSo found hyperLepTinemiA oUt oF PropoRtiOn witH body fAT mass iN children WiTH psychOLogical LOSs Of coNtrol (", "whitespace_perturbation": " to understand better theroles of M C3R i n p eri ph eral  met abolism. We ha v e pr eviously found that le ptinis an i m po rtant  predic t or o f w ei gh t g ai n  i n chi ldr en andidentified  ch il dren with hy p er leptinemia  an d leptin rec ept or mut at ion s . Wehav e als o foun d  hyper leptinemi ao ut ofp roporti o n  w ithbody fat mass inc hi l dren with psyc hologi ca l  l o s s o f c ontrol (", "underscore_trick": " to_understand better_the roles of MC3R_in peripheral_metabolism._We have_previously_found that leptin_is an important_predictor of weight gain_in children and_identified_children with hyperleptinemia and leptin receptor mutations. We have also found hyperleptinemia out of_proportion_with body_fat_mass_in children with psychological loss_of control ("}
{"text": "-related functions. Subsequent studies in mice whose Langerhans cells lacked EpCAM revealed that antibody-forming responses to proteins that were applied to skin were enhanced rather than predicted. Increased immune responses were associated with enhanced localization of antigen-bearing Langerhans cells in skin draining lymph nodes. These results have recently been", "synonym_substitution": "-related functions. Subsequent studies in mice whose Langerhans cells miss EpCAM reveal that antibody - forming responses to protein that were applied to peel were enhanced rather than predict. Increased immune responses were associate with enhanced localization of antigen - hold Langerhans cells in skin drain lymph node. These results have recently been", "butter_fingers": "-relwted functions. Subsequenu studies in mice whose Nangergans celus lacked EpCAM revealed thav anribodt-forming responses to oroteins nhat were appoued to skii were ekkances ratkec than predictec. Increaseg immune respotsds were associated with enhanced locajizatiom lf antigen-bearyng Kwngedhans cells in skin draining lymph nodes. Uhese results have recently been", "random_deletion": "-related functions. Subsequent studies in mice whose lacked revealed that responses to proteins were rather than predicted. immune responses were with enhanced localization of antigen-bearing Langerhans in skin draining lymph nodes. These results have recently been", "change_char_case": "-related functions. SubsequenT studies in Mice wHosE LaNgErhaNs ceLls lacked EpCAM REveaLed that antibody-forming RespoNsES to pROtEins tHat were APpLIEd tO sKiN weRe ENhAnced RatHer than Predicted. INcrEaSed immune resPOnSes were assOciAted with enhaNceD localIzAtiON of anTigEn-beaRing LaNGerhanS cells in sKiN DrainiNG lymph nODEs. thesE results have recenTLy BEen", "whitespace_perturbation": "-related functions. Subseq uent studi es in  mi cewh oseLang erhans cells l a cked  EpCAM revealed that a ntibo dy - form i ng  resp onses t o  p r o tei ns  t hat  w e re  appl ied  to ski n were enh anc ed  rather than pr edicted. I ncr eased immune  re sponse swer e  asso cia ted w ith en h ancedlocalizat io n  of an t igen-be a r in g La ngerhans cells in sk i n draining lym ph nod es .  T h e seres ults havere centl y  been", "underscore_trick": "-related functions._Subsequent studies_in mice whose Langerhans_cells lacked_EpCAM_revealed that_antibody-forming_responses to proteins_that were applied_to skin were enhanced_rather than predicted._Increased_immune responses were associated with enhanced localization of antigen-bearing Langerhans cells in skin draining_lymph_nodes. These_results_have_recently been"}
{"text": "otropin Pulsations in the Regulation of Puberty and Fertility At one extreme of pubertal development, isolated deficiency of GnRH results in a spectrum of rare clinical disorders of isolated GnRH deficiency (IGD), also known as idiopathic hypogonadotropic hypogonadism (IHH), which presents with", "synonym_substitution": "otropin Pulsations in the Regulation of Puberty and Fertility At one extreme of pubertal development, isolated deficiency of GnRH result in a spectrum of rare clinical disorder of isolated GnRH deficiency (IGD), also know as idiopathic hypogonadotropic hypogonadism (IHH), which presents with", "butter_fingers": "otrlpin Pulsations in the Rtgulation of Pubettt and Hertilify At ond extreme of pubertal develo'menr, isooated deficiency of GnFH resultd in a spectcum of rare clinmdal disorders lf ivilated GnRH deniciency (IGG), also known av kdnopathic hypogonadotropic hypogonadifm (IHH), ehlch presents wyth", "random_deletion": "otropin Pulsations in the Regulation of Puberty At extreme of development, isolated deficiency spectrum rare clinical disorders isolated GnRH deficiency also known as idiopathic hypogonadotropic hypogonadism which presents with", "change_char_case": "otropin Pulsations in the RegUlation of PUbertY anD FeRtIlitY At oNe extreme of pubERtal Development, isolated defIcienCy OF GnRh ReSults In a specTRuM OF raRe ClIniCaL DiSordeRs oF isolatEd GnRH defiCieNcY (IGD), also knowN As Idiopathic HypOgonadotropiC hyPogonaDiSm (Ihh), whicH prEsentS with", "whitespace_perturbation": "otropin Pulsations in theRegulation  of P ube rty  a nd F erti lity At one ex t reme  of pubertal developme nt, i so l ated de ficie ncy ofG nR H res ul ts  in  a sp ectru m o f rareclinical d iso rd ers of isola t ed  GnRH defi cie ncy (IGD), a lso  known  a s i d iopat hic  hypo gonado t ropichypogonad is m  (IHH) ,  whichp r es ents  with", "underscore_trick": "otropin Pulsations_in the_Regulation of Puberty and_Fertility At_one_extreme of_pubertal_development, isolated deficiency_of GnRH results_in a spectrum of_rare clinical disorders_of_isolated GnRH deficiency (IGD), also known as idiopathic hypogonadotropic hypogonadism (IHH), which presents with"}
{"text": " impact of an AKT1 functional variation on human medial temporal lobe (MTL) development and plasticity. We found another 3-way interaction of AKT1 with BDNF and COMT, adding to convergent evidence identifying effects of AKT1 variation in memory-dependent neuroplasticity and structural brain processes in development and SZ and", "synonym_substitution": "impact of an AKT1 functional variation on human medial worldly lobe (MTL) growth and plasticity. We found another 3 - direction interaction of AKT1 with BDNF and COMT, add to convergent evidence identifying effects of AKT1 pas seul in memory - subject neuroplasticity and structural mind processes in development and SZ and", "butter_fingers": " imoact of an AKT1 functionau variation on kyman mxdial tsmporal uobe (MTL) development and pladtucity. We found another 3-way knteractiln of AKR1 wiuh BDNF and COMT, esding to convsvgent xvidence identinying effecds of AKT1 varidtkou in memory-dependent neuroplasticity and sttuftural brain ptocesxqs ih development and SZ and", "random_deletion": "impact of an AKT1 functional variation on temporal (MTL) development plasticity. We found with and COMT, adding convergent evidence identifying of AKT1 variation in memory-dependent neuroplasticity structural brain processes in development and SZ and", "change_char_case": " impact of an AKT1 functional vaRiation on hUman mEdiAl tEmPoraL lobE (MTL) developmenT And pLasticity. We found anotheR 3-way iNtERactIOn Of AKT1 With BDNf AnD coMT, AdDiNg tO cONvErgenT evIdence iDentifying EffEcTs of AKT1 variaTIoN in memory-dEpeNdent neuroplAstIcity aNd StrUCturaL brAin prOcesseS In deveLopment anD Sz And", "whitespace_perturbation": " impact of an AKT1 functio nal variat ion o n h uma nmedi al t emporal lobe ( M TL)development and plasti city.  W e  fou n danoth er 3-wa y  i n t era ct io n o fA KT 1 wit h B DNF and  COMT, add ing  t o convergent ev idence ide nti fying effect s o f AKT1  v ari a tioninmemor y-depe n dent n europlast ic i ty and structu r a lbrai n processes in de v el o pment and SZ a nd", "underscore_trick": " impact_of an_AKT1 functional variation on_human medial_temporal_lobe (MTL)_development_and plasticity. We_found another 3-way_interaction of AKT1 with_BDNF and COMT,_adding_to convergent evidence identifying effects of AKT1 variation in memory-dependent neuroplasticity and structural brain_processes_in development_and_SZ_and"}
{"text": " differences are due to variations in specific host genes, and we have been engaged in an ongoing effort to identify and characterize host genes that are either involved in virus resistance or that contribute to the disease process. There are two types of host genes involved in virus-induced disease. First, the mouse genome contains copies of mouse g", "synonym_substitution": "differences are due to variations in specific host gene, and we have been engage in an ongoing effort to name and characterize master of ceremonies genes that are either involve in virus resistance or that contribute to the disease procedure. There are two types of server genes involved in virus - induce disease. First, the shiner genome contains copy of mouse g", "butter_fingers": " divferences are due to varlations in speciyuc hosv genes, and we fave been engaged in an ongomng wfforu to identify and cfaracteride host gwnes rhat are emfher inyjlves in ricus resistance pr that cottribute to tha aidease process. There are two types os host bejes involved ig viguf-indhbeb disease. First, the mouse genoms contapns copies of mouxe g", "random_deletion": "differences are due to variations in specific and have been in an ongoing host that are either in virus resistance that contribute to the disease process. are two types of host genes involved in virus-induced disease. First, the mouse contains copies of mouse g", "change_char_case": " differences are due to variatIons in specIfic hOst GenEs, And wE havE been engaged in AN ongOing effort to identify anD charAcTErizE HoSt genEs that aRE eITHer InVoLveD iN ViRus reSisTance or That contriButE tO the disease pROcEss. There arE twO types of host GenEs invoLvEd iN Virus-IndUced dIsease. fIrst, thE mouse genOmE ContaiNS copies OF MoUse g", "whitespace_perturbation": " differences are due to va riations i n spe cif icho st g enes , and we haveb eenengaged in an ongoingeffor tt o id e nt ify a nd char a ct e r ize  h os t g en e sthatare  either  involvedinvi rus resistan c eor that co ntr ibute to the  di seasepr oce s s. Th ere  aretwo ty p es ofhost gene si nvolve d  in vir u s -i nduc ed disease. First ,  t h e mouse genome  conta in s  c o p ies  of  mouse g", "underscore_trick": " differences_are due_to variations in specific_host genes,_and_we have_been_engaged in an_ongoing effort to_identify and characterize host_genes that are_either_involved in virus resistance or that contribute to the disease process. There are two_types_of host_genes_involved_in virus-induced disease. First, the_mouse genome contains copies of_mouse g"}
{"text": " have one manuscript that has been submitted for publication and another paper in progress. During this past year, we have also partnered with the INSIGHTS study team to develop a project under this protocol that examines the social contextual factors that surround families affected by Sickle Cell Disease. We have successfully recruited 101 participants from 45 families", "synonym_substitution": "have one manuscript that has been submitted for publication and another paper in advancement. During this past class, we have besides partnered with the INSIGHTS study team to develop a undertaking under this protocol that examines the social contextual factors that surround kin affected by Sickle Cell Disease. We have successfully recruited 101 participant from 45 families", "butter_fingers": " hage one manuscript that hxs been submittgd for pnblicatjon and xnother paper in progress. Ducing this past year, we have alsu partnervd with tye IISIGHTS study teej to deyzlop z prolert under this ptotocol that examines the vozicl contextual factors that surround samiliex wffected by Siskle Sell Disease. We have successfully recrhited 101 karticipants from 45 families", "random_deletion": "have one manuscript that has been submitted and paper in During this past with INSIGHTS study team develop a project this protocol that examines the social factors that surround families affected by Sickle Cell Disease. We have successfully recruited participants from 45 families", "change_char_case": " have one manuscript that has bEen submittEd for PubLicAtIon aNd anOther paper in prOGresS. During this past year, we hAve alSo PArtnEReD with The INSIghTs STudY tEaM to DeVElOp a prOjeCt under This protocOl tHaT examines the SOcIal contextUal Factors that sUrrOund faMiLieS AffecTed By SicKle CelL diseasE. We have suCcESsfullY RecruitED 101 PaRticIpants from 45 familieS", "whitespace_perturbation": " have one manuscript thathas been s ubmit ted  fo rpubl icat ion and anothe r  pap er in progress. During  this  p a st y e ar , wehave al s op a rtn er ed  wi th th e INS IGH TS stud y team todev el op a project un der this p rot ocol that ex ami nes th esoc i al co nte xtual  facto r s that  surround  f a milies affecte d by  Sic kle Cell Disease. We have successfu lly re cr u it e d  10 1 p articipant sfrom4 5 famil i es ", "underscore_trick": " have_one manuscript_that has been submitted_for publication_and_another paper_in_progress. During this_past year, we_have also partnered with_the INSIGHTS study_team_to develop a project under this protocol that examines the social contextual factors that_surround_families affected_by_Sickle_Cell Disease. We have successfully_recruited 101 participants from 45_families"}
{"text": "ST-2 variants were expressed at the cell surface at wild type levels or above. Our results also demonstrate significant flexibility in the positioning of cysteine residues with regard to BST-2 dimerization even though the propensity to catalyze dimerization generally decreased with increasing proximity of the cysteines to the C-terminus of the", "synonym_substitution": "ST-2 variants were expressed at the cell surface at raving mad character levels or above. Our results besides demonstrate meaning flexibility in the positioning of cysteine remainder with esteem to BST-2 dimerization even though the propensity to catalyze dimerization by and large decreased with increasing proximity of the cysteine to the C - terminus of the", "butter_fingers": "ST-2 gariants were expressed xt the cell suryqce at wild fype levdls or above. Our results alsl eemonwtrate significant flebibility pn the powitiibing of cysteine rcfidusd wich regard to BST-2 dimerizathon even thougv ghz propensity to catalyze dimerizatiog generslpy decreased wyth pnsreaapnn proximity of the cysteines to fhe C-tegminus of the", "random_deletion": "ST-2 variants were expressed at the cell wild levels or Our results also positioning cysteine residues with to BST-2 dimerization though the propensity to catalyze dimerization decreased with increasing proximity of the cysteines to the C-terminus of the", "change_char_case": "ST-2 variants were expressed at The cell surFace aT wiLd tYpE levEls oR above. Our resulTS alsO demonstrate significanT flexIbILity IN tHe posItioninG Of CYSteInE rEsiDuES wIth reGarD to BST-2 dImerizatioN evEn Though the proPEnSity to cataLyzE dimerizatioN geNerallY dEcrEAsed wIth IncreAsing pROximitY of the cysTeINes to tHE C-termiNUS oF the", "whitespace_perturbation": "ST-2 variants were express ed at thecellsur fac eat w ildtype levels or abov e. Our results also de monst ra t e si g ni fican t flexi b il i t y i nth e p os i ti oning  of  cystei ne residue s w it h regard toB ST -2 dimeriz ati on even thou ghthe pr op ens i ty to  ca talyz e dime r izatio n general ly decrea s ed with i nc reas ing proximity oft he cysteines to t he C-t er m in u s  of  th e", "underscore_trick": "ST-2 variants_were expressed_at the cell surface_at wild_type_levels or_above._Our results also_demonstrate significant flexibility_in the positioning of_cysteine residues with_regard_to BST-2 dimerization even though the propensity to catalyze dimerization generally decreased with increasing_proximity_of the_cysteines_to_the C-terminus of the"}
{"text": " ETV at 1 to 105 nM concentrations failed to effectively block the DNA synthesis of HBVETV-RL180M/S202G/M204V even at the highest concentration (105 nM), giving ETV's IC50 value of 64,040 nM, although ETV fairly well blocked the synthesis of HBVAD", "synonym_substitution": "ETV at 1 to 105 nM concentrations failed to effectively block the deoxyribonucleic acid deduction of HBVETV - RL180M / S202G / M204V even at the high concentration (105 nM), giving ETV's IC50 value of 64,040 nM, although ETV reasonably well blocked the synthesis of HBVAD", "butter_fingers": " ETG at 1 to 105 nM concentratiuns failed to eydectivxly blodk the DVA synthesis of HBVETV-RL180M/S202G/M204T evwn at the highest concentragion (105 nM), hiving ERV's MC50 value of 64,040 nM, emthough ETV fzlrly ceol blocked the synthesis of HBVAD", "random_deletion": "ETV at 1 to 105 nM concentrations effectively the DNA of HBVETV-RL180M/S202G/M204V even nM), ETV's IC50 value 64,040 nM, although fairly well blocked the synthesis of", "change_char_case": " ETV at 1 to 105 nM concentrations faIled to effeCtiveLy bLocK tHe DNa synThesis of HBVETV-rl180M/S202G/m204V even at the highest concEntraTiON (105 nM), gIViNg ETV'S IC50 valuE Of 64,040 Nm, AltHoUgH ETv fAIrLy welL blOcked thE synthesis Of HbVaD", "whitespace_perturbation": " ETV at 1 to 105 nM concen trations f ailed  to  ef fe ctiv elyblock the DNAs ynth esis of HBVETV-RL180M/ S202G /M 2 04Ve ve n atthe hig h es t con ce nt rat io n  ( 105 n M),  giving  ETV's IC5 0 v al ue of 64,040 nM , although  ET V fairly wel l b locked  t hes ynthe sis  of H BVAD", "underscore_trick": " ETV_at 1_to 105 nM concentrations_failed to_effectively_block the_DNA_synthesis of HBVETV-RL180M/S202G/M204V_even at the_highest concentration (105 nM),_giving ETV's IC50_value_of 64,040 nM, although ETV fairly well blocked the synthesis of HBVAD"}
{"text": " mucosa indicated widespread, independent, multifocal tumorigenesis. Analyses of mitochondrial DNA confirmed the independent origin of the ACECs. We have also shown that fully differentiated EECs residing predominantly at the +4 position in the crypt have features of both label retaining cells (LRC) and intestinal stem cells (ISC) and are capable of", "synonym_substitution": "mucosa indicated widespread, independent, multifocal tumorigenesis. Analyses of mitochondrial DNA confirm the autonomous origin of the ACECs. We have also testify that in full differentiated EECs reside predominantly at the +4 position in the crypt have feature of both label retaining cells (LRC) and intestinal bow cells (ISC) and are capable of", "butter_fingers": " mufosa indicated widespreaa, independent, molrifocan tumodigenesir. Analyses of mitochondrial VNA xonfiemed the independent ofigin of nhe ACECs. We iave also shown vgat fully difrcrentnaved EECs residikg predomindntly at the +4 [oricion in the crypt have features of bjth labrl retaining celjs (LGC) and pnuestinal stem cells (ISC) and are czpable mf", "random_deletion": "mucosa indicated widespread, independent, multifocal tumorigenesis. Analyses DNA the independent of the ACECs. fully EECs residing predominantly the +4 position the crypt have features of both retaining cells (LRC) and intestinal stem cells (ISC) and are capable of", "change_char_case": " mucosa indicated widespread, IndependenT, multIfoCal TuMoriGeneSis. Analyses of mITochOndrial DNA confirmed the IndepEnDEnt oRIgIn of tHe ACECs. wE hAVE alSo ShOwn ThAT fUlly dIffErentiaTed EECs resIdiNg PredominantlY At The +4 positioN in The crypt have FeaTures oF bOth LAbel rEtaIning Cells (Lrc) and inTestinal sTeM Cells (Isc) and are CAPaBle oF", "whitespace_perturbation": " mucosa indicated widespre ad, indepe ndent , m ult if ocal  tum origenesis. An a lyse s of mitochondrial DNA  conf ir m ed t h eindep endento ri g i n o fth e A CE C s.  We h ave  also s hown thatful ly  differentia t ed  EECs resi din g predominan tly  at th e+4p ositi onin th e cryp t  havefeaturesof both l a bel ret a i ni ng c ells (LRC) and in t es t inal stem cell s (ISC )a nd a recap able of", "underscore_trick": " mucosa_indicated widespread,_independent, multifocal tumorigenesis. Analyses_of mitochondrial_DNA_confirmed the_independent_origin of the_ACECs. We have_also shown that fully_differentiated EECs residing_predominantly_at the +4 position in the crypt have features of both label retaining cells_(LRC)_and intestinal_stem_cells_(ISC) and are capable of"}
{"text": " myopathy. The section is comprised of Drs. Steven Vogel (Chief), Srinagesh Koushik (Research Fellow), Christopher Thaler (Postdoctoral IRTA), and Jose Fernando Covian-Nares (Visiting Fellow). The sections initial efforts have been in building and testing a laser", "synonym_substitution": "myopathy. The section is comprised of Drs. Steven Vogel (Chief), Srinagesh Koushik (Research Fellow), Christopher Thaler (Postdoctoral IRTA), and Jose Fernando Covian - Nares (Visiting Fellow). The sections initial feat have been in build and testing a laser", "butter_fingers": " mylpathy. The section is cooprised of Drs. Steven Togel (Cgief), Srivagesh Koushik (Research Felllw), Chriwtopher Thaler (Postdocgoral IRTW), and Jowe Ftrnando Covian-Narxa (Visitlug Fempow). Chx sections initlal efforts have been in tuklbing and testing a laser", "random_deletion": "myopathy. The section is comprised of Drs. (Chief), Koushik (Research Christopher Thaler (Postdoctoral (Visiting The sections initial have been in and testing a laser", "change_char_case": " myopathy. The section is comprIsed of Drs. STeven vogEl (CHiEf), SrInagEsh Koushik (ReseARch FEllow), Christopher Thaler (postdOcTOral irTa), and JOse FernANdO cOviAn-naRes (viSItIng FeLloW). The secTions initiAl eFfOrts have been IN bUilding and TesTing a laser", "whitespace_perturbation": " myopathy. The section iscomprisedof Dr s.Ste ve n Vo gel(Chief), Srina g eshKoushik (Research Fell ow),Ch r isto p he r Tha ler (Po s td o c tor al  I RTA ), an d Jos e F ernando  Covian-Na res  ( Visiting Fel l ow ). The sec tio ns initial e ffo rts ha ve  be e n inbui lding  and t e stinga laser", "underscore_trick": " myopathy._The section_is comprised of Drs._Steven Vogel_(Chief),_Srinagesh Koushik_(Research_Fellow), Christopher Thaler_(Postdoctoral IRTA), and_Jose Fernando Covian-Nares (Visiting_Fellow). The sections_initial_efforts have been in building and testing a laser"}
{"text": "204V) as examined in HBVL180M/S202G/M204V-plasmid-transfected Huh7 cells and HBVL180M/S202G/M204V-exposed hu-liver-chimeric mice. However, both compounds proved to be greatly more cytotoxic than ETV", "synonym_substitution": "204V) as examined in HBVL180M / S202G / M204V - plasmid - transfected Huh7 cells and HBVL180M / S202G / M204V - exposed hu - liver - chimeric mice. However, both compound prove to be greatly more cytotoxic than ETV", "butter_fingers": "204V) ad examined in HBVL180M/S202G/M204V-puasmid-transfectgd Huh7 cxlls ans HBVL180M/S202E/M204V-exposed hu-liver-chimeric mmce. Yowevtg, both compounds provdd to be hreatly nore xytotoxic vgan ETV", "random_deletion": "204V) as examined in HBVL180M/S202G/M204V-plasmid-transfected Huh7 cells hu-liver-chimeric However, both proved to be", "change_char_case": "204V) as examined in HBVL180M/S202G/M204V-plaSmid-transfEcted huh7 CelLs And HbVL180M/s202G/M204V-exposed hu-lIVer-cHimeric mice. However, both CompoUnDS proVEd To be gReatly mORe CYTotOxIc ThaN Etv", "whitespace_perturbation": "204V) as examined in HBVL1 80M/S202G/ M204V -pl asm id -tra nsfe cted Huh7 cell s  and  HBVL180M/S202G/M204V- expos ed hu-l i ve r-chi meric m i ce . How ev er , b ot h  c ompou nds  proved  to be gre atl ymore cytotox i cthan ETV", "underscore_trick": "204V) as_examined in_HBVL180M/S202G/M204V-plasmid-transfected Huh7 cells and_HBVL180M/S202G/M204V-exposed hu-liver-chimeric_mice._However, both_compounds_proved to be_greatly more cytotoxic_than ETV"}
{"text": " same conditions (p=0.10). In 8 weeks following the inoculation of hu-liver-chimeric mice with an HBVETV-RL180M/S202G/M204V, the viremia levels had reached 7 x 107 to 2 x 108/ml. However, ETV,", "synonym_substitution": "same conditions (p=0.10). In 8 weeks following the inoculation of hu - liver - chimeric mouse with an HBVETV - RL180M / S202G / M204V, the viremia degree had reached 7 x 107 to 2 x 108 / ml. However, ETV,", "butter_fingers": " sale conditions (p=0.10). In 8 weekr following the inoculetion or hu-livef-chimeric mice with an HBVETT-RL180M/W202G/M204V, uke viremia levels haa reached 7 x 107 to 2 x 108/mo. However, EVB,", "random_deletion": "same conditions (p=0.10). In 8 weeks following of mice with HBVETV-RL180M/S202G/M204V, the viremia 107 2 x 108/ml. ETV,", "change_char_case": " same conditions (p=0.10). In 8 weeks folLowing the iNoculAtiOn oF hU-livEr-chImeric mice with AN HBVeTV-RL180M/S202G/M204V, the viremia leVels hAd REachED 7 x 107 To 2 x 108/ml. however, etV,", "whitespace_perturbation": " same conditions (p=0.10).  In 8 week s fol low ing  t he i nocu lation of hu-l i ver- chimeric mice with anHBVET V- R L180 M /S 202G/ M204V,t he v ire mi alev el s  h ad re ach ed 7 x107 to 2 x  10 8/ ml. However, ET V,", "underscore_trick": " same_conditions (p=0.10)._In 8 weeks following_the inoculation_of_hu-liver-chimeric mice_with_an HBVETV-RL180M/S202G/M204V, the_viremia levels had_reached 7 x 107_to 2 x_108/ml._However, ETV,"}
{"text": " synaptic plasticity has been to compare highly plastic brain areas, such as the CA1 area of hippocampus, with less plastic areas. From the expression pattern of some genes, we predicted and found that one area of the hippocampus, the CA2, would have a resistance to synaptic plasticity including LTP and LTD, even though", "synonym_substitution": "synaptic plasticity has been to compare highly plastic brain areas, such as the CA1 sphere of hippocampus, with less fictile areas. From the expression design of some gene, we predicted and found that one area of the hippocampus, the CA2, would hold a resistance to synaptic plasticity include LTP and LTD, even though", "butter_fingers": " syjaptic plasticity has betn to compare higkoy plavtic bdain arexs, such as the CA1 area of hi'pocqmpus, with less plastic arexs. From tje exprewsioi pattern of somx genes, we preslcted end found that pne area ox the hippocam[ur, che CA2, would have a resistance to sygaptic llwsticity incluqing JTP znd LTD, even though", "random_deletion": "synaptic plasticity has been to compare highly areas, as the area of hippocampus, the pattern of some we predicted and that one area of the hippocampus, CA2, would have a resistance to synaptic plasticity including LTP and LTD, even", "change_char_case": " synaptic plasticity has been To compare hIghly PlaStiC bRain AreaS, such as the CA1 arEA of hIppocampus, with less plasTic arEaS. from THe ExpreSsion paTTeRN Of sOmE gEneS, wE PrEdictEd aNd found That one areA of ThE hippocampus, THe cA2, would havE a rEsistance to sYnaPtic plAsTicITy incLudIng LTp and LTd, Even thOugh", "whitespace_perturbation": " synaptic plasticity has b een to com parehig hly  p last ic b rain areas, su c h as  the CA1 area of hippo campu s, with le ss pl astic a r ea s .  Fr om  t heex p re ssion  pa ttern o f some gen es,  w e predicteda nd  found tha t o ne area of t hehippoc am pus ,  theCA2 , wou ld hav e  a res istance t os ynapti c  plasti c i ty  inc luding LTP and LT D ,e ven though", "underscore_trick": " synaptic_plasticity has_been to compare highly_plastic brain_areas,_such as_the_CA1 area of_hippocampus, with less_plastic areas. From the_expression pattern of_some_genes, we predicted and found that one area of the hippocampus, the CA2, would_have_a resistance_to_synaptic_plasticity including LTP and LTD,_even though"}
{"text": " 3) to identify individual factors that affect response to intervention. As in Phase I, the primary analytical approach to detecting treatment effects on both cognitive and functional abilities will be a repeated-measures, mixed-effects model incorporating all design features as fixed effects and individual-level variability as random effects. Other multivariate analyses including lagged", "synonym_substitution": "3) to identify individual factors that affect response to interposition. As in Phase I, the basal analytical approach to detecting discussion effects on both cognitive and functional abilities will be a repeat - measures, mixed - consequence model incorporating all invention features as fixed effect and individual - level unevenness as random effects. early multivariate analysis including lagged", "butter_fingers": " 3) tl identify individual fagtors that affecj eesponve to jntervengion. As in Phase I, the primacy abalytucal approach to detecging treanment effwcts in both cojhitive and fuhgtioncl abilities wilk be a repaated-measures, kibeb-effects model incorporating all desygn feayuges as fixed esfecus wnd jndividual-level variability as ransom efftcts. Other multivatiate analyses including lwggef", "random_deletion": "3) to identify individual factors that affect intervention. in Phase the primary analytical on cognitive and functional will be a mixed-effects model incorporating all design features fixed effects and individual-level variability as random effects. Other multivariate analyses including lagged", "change_char_case": " 3) to identify individual factoRs that affeCt resPonSe tO iNterVentIon. As in Phase I, tHE priMary analytical approach To detEcTIng tREaTment Effects ON bOTH coGnItIve AnD FuNctioNal AbilitiEs will be a rEpeAtEd-measures, miXEd-Effects modEl iNcorporating All Design FeAtuREs as fIxeD effeCts and INdividUal-level vArIAbilitY As randoM EFfEcts. other multivariate ANaLYses including lAgged", "whitespace_perturbation": " 3) to identify individual  factors t hat a ffe ctre spon se t o intervention .  Asin Phase I, the primar y ana ly t ical ap proac h to de t ec t i ngtr ea tme nt ef fects  on  both c ognitive a ndfu nctional abi l it ies will b e a  repeated-me asu res, m ix ed- e ffect s m odelincorp o rating  all desi gn featur e s as fi x e deffe cts and individua l -l e vel variabilit y as r an d om e ffe cts . Other mu lt ivari a te anal y se s i ncl u ding lagged", "underscore_trick": " 3)_to identify_individual factors that affect_response to_intervention._As in_Phase_I, the primary_analytical approach to_detecting treatment effects on_both cognitive and_functional_abilities will be a repeated-measures, mixed-effects model incorporating all design features as fixed effects_and_individual-level variability_as_random_effects. Other multivariate analyses including_lagged"}
{"text": " a substantial population of mitochondria in the terminals. Drugs that inhibit microtubule-based kinesin motors stalled mitochondria in the axon. From this work we conclude that this prominent microtubule band is important for the transport and localization of critical mitochondria into the presynaptic space to provide the sustained energy necessary for continuous transmitter release in these giant synaptic", "synonym_substitution": "a substantial population of mitochondria in the terminals. Drugs that inhibit microtubule - free-base kinesin motors stall mitochondria in the axon. From this work we conclude that this prominent microtubule dance band is important for the transport and localization of function of critical mitochondria into the presynaptic space to provide the free burning department of energy necessary for continuous transmitter release in these elephantine synaptic", "butter_fingers": " a dubstantial population on mitochondria iu the txrminala. Drugs ghat inhibit microtubule-basev kibesin motors stalled mitochundria in the axob. Frin this work we congjude bhat chms prominent migrotubule bdnd is importatt flr the transport and localization os critivap mitochondria intp the irtsynaptic space to provide the suatained energy necesxary for continuous transmltteg release in these giant synakfic", "random_deletion": "a substantial population of mitochondria in the that microtubule-based kinesin stalled mitochondria in we that this prominent band is important the transport and localization of critical into the presynaptic space to provide the sustained energy necessary for continuous transmitter in these giant synaptic", "change_char_case": " a substantial population of mItochondriA in thE teRmiNaLs. DrUgs tHat inhibit micrOTubuLe-based kinesin motors stAlled MiTOchoNDrIa in tHe axon. FROm THIs wOrK wE coNcLUdE that ThiS prominEnt microtuBulE bAnd is importaNT fOr the transPorT and localizaTioN of criTiCal MItochOndRia inTo the pREsynapTic space tO pROvide tHE sustaiNED eNergY necessary for contINuOUs transmitter rElease In THeSE GiaNt sYnaptic", "whitespace_perturbation": " a substantial populationof mitocho ndria  in  th eterm inal s. Drugs thati nhib it microtubule-based k inesi nm otor s  s talle d mitoc h on d r iain  t heax o n.  From  th is work  we conclu deth at this prom i ne nt microtu bul e band is im por tant f or  th e  tran spo rt an d loca l izatio n of crit ic a l mito c hondria i nt o th e presynaptic spa c et o provide thesustai ne d  e n e rgy  ne cessary fo rconti n uous tr a ns m i t ter release in th ese giant s y nap tic", "underscore_trick": " a_substantial population_of mitochondria in the_terminals. Drugs_that_inhibit microtubule-based_kinesin_motors stalled mitochondria_in the axon._From this work we_conclude that this_prominent_microtubule band is important for the transport and localization of critical mitochondria into the_presynaptic_space to_provide_the_sustained energy necessary for continuous_transmitter release in these giant_synaptic"}
{"text": "pl13). By 3 m of age, the list of differentially expressed DNA repair genes was increased to include Ddb2, Mlh1, Msh3, Rad51ap1, along with upregulation of genes involved in fatty acid beta-oxidation (Acaa1b, Acadm), and detoxication", "synonym_substitution": "pl13). By 3 m of age, the list of differentially expressed DNA haunt gene was increase to include Ddb2, Mlh1, Msh3, Rad51ap1, along with upregulation of gene involved in fatty acid beta - oxidation (Acaa1b, Acadm), and detoxication", "butter_fingers": "pl13). Hy 3 m of age, the list of differentially expresved DNZ repair genes was increased to inclnde Edb2, Moh1, Msh3, Rad51ap1, along witf upregulwtion of gents involved in favfy acid beta-osldatimi (Acaa1b, Acadm), akd detoxicadion", "random_deletion": "pl13). By 3 m of age, the differentially DNA repair was increased to along upregulation of genes in fatty acid (Acaa1b, Acadm), and detoxication", "change_char_case": "pl13). By 3 m of age, the list of differEntially exPressEd DnA rEpAir gEnes Was increased to INcluDe Ddb2, Mlh1, Msh3, Rad51ap1, along wIth upReGUlatIOn Of genEs involVEd IN FatTy AcId bEtA-OxIdatiOn (ACaa1b, AcaDm), and detoxIcaTiOn", "whitespace_perturbation": "pl13). By 3 m of age, thelist of di ffere nti all yexpr esse d DNA repair g e neswas increased to inclu de Dd b2 ,  Mlh 1 ,Msh3,  Rad51a p 1, a lon gwi thup r eg ulati onof gene s involved  in  f atty acid be t a- oxidation(Ac aa1b, Acadm) , a nd det ox ica t ion", "underscore_trick": "pl13). By_3 m_of age, the list_of differentially_expressed_DNA repair_genes_was increased to_include Ddb2, Mlh1,_Msh3, Rad51ap1, along with_upregulation of genes_involved_in fatty acid beta-oxidation (Acaa1b, Acadm), and detoxication"}
{"text": " highly immunogenic and protective. This was somewhat surprising, since the NA protein had not been considered to be a potent neutralization or protective antigen. These results showed that the modified HA gene and the NA gene are the genes of choice for inclusion in a vectored vaccine for human use. IN administration would be feasible in", "synonym_substitution": "highly immunogenic and protective. This was somewhat surprising, since the NA protein had not been considered to be a potent neutralization or protective antigen. These results showed that the limited HA gene and the NA gene are the gene of option for inclusion in a vectored vaccine for human use. IN administration would be feasible in", "butter_fingers": " hihhly immunogenic and prouective. This was somewhav surprjsing, sivce the NA protein had not bxen xonsieered to be a potent ndutralizanion or peotertive antigen. Thxae results shkaed chet the modified HA gene atd the NA gene afe the genes of choice for inclusion yn a vevtlred vaccine fjr hlmwn uav. LN administration would be feasigle in", "random_deletion": "highly immunogenic and protective. This was somewhat the protein had been considered to protective These results showed the modified HA and the NA gene are the of choice for inclusion in a vectored vaccine for human use. IN administration be feasible in", "change_char_case": " highly immunogenic and proteCtive. This wAs somEwhAt sUrPrisIng, sInce the NA proteIN had Not been considered to be a PotenT nEUtraLIzAtion Or proteCTiVE AntIgEn. theSe REsUlts sHowEd that tHe modified hA gEnE and the NA genE ArE the genes oF chOice for incluSioN in a veCtOreD VacciNe fOr humAn use. In AdminiStration wOuLD be feaSIble in", "whitespace_perturbation": " highly immunogenic and pr otective.Thiswas  so me what  sur prising, since theNA protein had not bee n con si d ered to  be a  potent ne u t ral iz at ion  o r  p rotec tiv e antig en. Theseres ul ts showed th a tthe modifi edHA gene andthe  NA ge ne  ar e  thegen es of  choic e  for i nclusionin a vect o red vac c i ne  for  human use. IN ad m in i stration would  be fe as i bl e in", "underscore_trick": " highly_immunogenic and_protective. This was somewhat_surprising, since_the_NA protein_had_not been considered_to be a_potent neutralization or protective_antigen. These results_showed_that the modified HA gene and the NA gene are the genes of choice_for_inclusion in_a_vectored_vaccine for human use. IN_administration would be feasible in"}
{"text": "oviruses as potential human vaccine vectors against highly pathogenic viruses. We previously evaluated human parainfluenza virus type 3 (HPIV3) as a vector to express the spike glycoprotein of Severe Acute Respiratory Syndrome Coronavirus (SARS). A single dose of the HPIV3-S construct administered by the combined int", "synonym_substitution": "oviruses as potential human vaccine vectors against highly pathogenic viruses. We previously measure human parainfluenza virus character 3 (HPIV3) as a vector to express the spike glycoprotein of Severe Acute Respiratory Syndrome Coronavirus (SARS). A single venereal disease of the HPIV3 - S concept administered by the combined int", "butter_fingers": "oviguses as potential human vaccine vectors againvt higgly pathugenic viruses. We previously ecaluauvd human parainfluenzx virus tjpe 3 (HPIV3) as e vector to exprxas the spike fpyco'ritein of Severg Acute Resphratory Syndroke Clronavirus (SARS). A single dose of thq HPIV3-S clnstruct adminystegeq by nht combined int", "random_deletion": "oviruses as potential human vaccine vectors against viruses. previously evaluated parainfluenza virus type to the spike glycoprotein Severe Acute Respiratory Coronavirus (SARS). A single dose of HPIV3-S construct administered by the combined int", "change_char_case": "oviruses as potential human vAccine vectOrs agAinSt hIgHly pAthoGenic viruses. We PReviOusly evaluated human parAinflUeNZa viRUs Type 3 (HpIV3) as a vECtOR To eXpReSs tHe SPiKe glyCopRotein oF Severe AcuTe REsPiratory SyndROmE CoronavirUs (SaRS). A single doSe oF the HPiV3-s coNStrucT adMinisTered bY The comBined int", "whitespace_perturbation": "oviruses as potential huma n vaccinevecto rsaga in st h ighl y pathogenic v i ruse s. We previously evalu atedhu m an p a ra influ enza vi r us t ype  3  ( HPI V3 )  a s a v ect or to e xpress the  sp ik e glycoprote i nof SevereAcu te Respirato rySyndro me  Co r onavi rus  (SAR S). As ingledose of t he HPIV3- S  constr u c tadmi nistered by the c o mb i ned int", "underscore_trick": "oviruses as_potential human_vaccine vectors against highly_pathogenic viruses._We_previously evaluated_human_parainfluenza virus type_3 (HPIV3) as_a vector to express_the spike glycoprotein_of_Severe Acute Respiratory Syndrome Coronavirus (SARS). A single dose of the HPIV3-S construct administered_by_the combined_int"}
{"text": " activated in patients with NOMID which is similar to bone lesions of other non-inflammatory conditions including fibrous dysplasia, osteochondromyxomas, and chondro- and osteo-sarcomas. These pathways all result in activation of the wnt signaling pathways and are dependent on active caspase-1 but not on", "synonym_substitution": "activated in patients with NOMID which is similar to bone lesions of early non - incendiary condition including hempen dysplasia, osteochondromyxomas, and chondro- and osteo - sarcomas. These pathway all result in activation of the wnt sign pathways and are dependent on active caspase-1 but not along", "butter_fingers": " achivated in patients with NOMID which is similac to bohe lesiovs of other non-inflammatory rondutionw including fibrous dyrplasia, odteochonerombxomas, and chondck- and osteo-sadgomas. Vhese pathways sll result in activation ow che wnt signaling pathways and are dqpendeny ln active caspwse-1 ntt nkn in", "random_deletion": "activated in patients with NOMID which is bone of other conditions including fibrous osteo-sarcomas. pathways all result activation of the signaling pathways and are dependent on caspase-1 but not on", "change_char_case": " activated in patients with NOmID which is SimilAr tO boNe LesiOns oF other non-inflaMMatoRy conditions including fIbrouS dYSplaSIa, OsteoChondroMYxOMAs, aNd ChOndRo- ANd Osteo-SarComas. ThEse pathwayS alL rEsult in activATiOn of the wnt SigNaling pathwaYs aNd are dEpEndENt on aCtiVe casPase-1 buT Not on", "whitespace_perturbation": " activated in patients wit h NOMID wh ich i s s imi la r to  bon e lesions of o t hernon-inflammatory condi tions  i n clud i ng  fibr ous dys p la s i a,os te och on d ro myxom as,  and ch ondro- and  os te o-sarcomas.T he se pathway s a ll result in  ac tivati on  of the w ntsigna ling p a thways  and arede p endent on acti v e  c aspa se-1 but not on", "underscore_trick": " activated_in patients_with NOMID which is_similar to_bone_lesions of_other_non-inflammatory conditions including_fibrous dysplasia, osteochondromyxomas,_and chondro- and osteo-sarcomas._These pathways all_result_in activation of the wnt signaling pathways and are dependent on active caspase-1 but_not_on"}
{"text": " occurs asymmetrically. In summary, the our data support a neutral drift model dominated by asymmetric cell division of ISCs as the basis of homeostatic maintenance of the rapidly renewing intestinal epithelium. Validated clinical pharmacodynamic (PD) assays that reliably quantify drug effects on molecular targets in tissue specimens are critical tools for converting molecular", "synonym_substitution": "occurs asymmetrically. In summary, the our data support a neutral drift exemplar dominate by asymmetric cell division of ISCs as the footing of homeostatic maintenance of the rapidly renewing intestinal epithelium. validate clinical pharmacodynamic (PD) assays that reliably quantify drug consequence on molecular targets in tissue specimens are critical cock for converting molecular", "butter_fingers": " ocfurs asymmetrically. In smmmary, the our dcra sup'ort a heutral arift model dominated by asylmwtric cell division of ISCs as the bwsis of yomeiwtatic maiifenance of ths rapndoy renewing injestinal epidhelium. Validadea elinical pharmacodynamic (PD) assays trat reloahly quantify dtug egsecta on molecular targets in tissue slecimenv are criticak tools for converting molfculwr", "random_deletion": "occurs asymmetrically. In summary, the our data neutral model dominated asymmetric cell division of maintenance of the renewing intestinal epithelium. clinical pharmacodynamic (PD) assays that reliably drug effects on molecular targets in tissue specimens are critical tools for converting", "change_char_case": " occurs asymmetrically. In sumMary, the our Data sUppOrt A nEutrAl drIft model dominaTEd by Asymmetric cell division Of ISCS aS The bASiS of hoMeostatIC mAINteNaNcE of ThE RaPidly RenEwing inTestinal epIthElIum. Validated CLiNical pharmAcoDynamic (PD) assAys That reLiAblY QuantIfy Drug eFfects ON molecUlar targeTs IN tissuE SpecimeNS ArE criTical tools for convERtINg molecular", "whitespace_perturbation": " occurs asymmetrically. In  summary,the o urdat asupp orta neutral drif t  mod el dominated by asymme tricce l l di v is ion o f ISCsa st h e b as is  of  h o me ostat icmainten ance of th e r ap idly renewin g  i ntestinalepi thelium. Val ida ted cl in ica l  phar mac odyna mic (P D ) assa ys that r el i ably q u antifyd r ug  eff ects on molecular ta r gets in tissue  speci me n sa r e c rit ical tools  f or co n verting mo l e c ula r ", "underscore_trick": " occurs_asymmetrically. In_summary, the our data_support a_neutral_drift model_dominated_by asymmetric cell_division of ISCs_as the basis of_homeostatic maintenance of_the_rapidly renewing intestinal epithelium. Validated clinical pharmacodynamic (PD) assays that reliably quantify drug effects_on_molecular targets_in_tissue_specimens are critical tools for_converting molecular"}
{"text": " endocrine precursor cells have not been fully characterized, key transcription factors have been implicated in enteroendocrine cell differentiation (Pax4, Pax6, BETA2/NeuorD, Pdx1, Gfi, Nkx2.2 and Sox9). There is a relationship between spatial orientation", "synonym_substitution": "endocrine precursor cells have not been fully qualify, cardinal transcription factors have been implicate in enteroendocrine cellular telephone differentiation (Pax4, Pax6, BETA2 / NeuorD, Pdx1, Gfi, Nkx2.2 and Sox9). There is a relationship between spatial predilection", "butter_fingers": " enfocrine precursor cells mave not been fully chacacteriaed, key granscription factors have bxen umplixated in enteroendocrive cell dpfferentiqtioi (Pax4, Pax6, BETA2/NenkrD, Pdx1, Gfi, Niw2.2 and Wox9). There is a relationsvip between spdtkap orientation", "random_deletion": "endocrine precursor cells have not been fully transcription have been in enteroendocrine cell Gfi, and Sox9). There a relationship between orientation", "change_char_case": " endocrine precursor cells haVe not been fUlly cHarActErIzed, Key tRanscription faCTors Have been implicated in enTeroeNdOCrinE CeLl difFerentiATiON (pax4, paX6, BeTA2/neUOrd, Pdx1, GFi, NKx2.2 and SoX9). There is a rElaTiOnship betweeN SpAtial orienTatIon", "whitespace_perturbation": " endocrine precursor cells  have notbeenful lych arac teri zed, key trans c ript ion factors have beenimpli ca t ed i n  e ntero endocri n ec e lldi ff ere nt i at ion ( Pax 4, Pax6 , BETA2/Ne uor D,  Pdx1, Gfi,N kx 2.2 and So x9) . There is a  re lation sh ipb etwee n s patia l orie n tation ", "underscore_trick": " endocrine_precursor cells_have not been fully_characterized, key_transcription_factors have_been_implicated in enteroendocrine_cell differentiation (Pax4,_Pax6, BETA2/NeuorD, Pdx1, Gfi,_Nkx2.2 and Sox9)._There_is a relationship between spatial orientation"}
{"text": " acitivty in rabbits; this construct is being extended to preclinical studies in Aotus monkeys. We have continued to expand our studies on transmission blocking immunity and in collaboration with PATH/MVI, we are performing mosquito membrane feeding assays (MFA). This involves culturing P. falciparum sexual stages in vitro,", "synonym_substitution": "acitivty in rabbits; this construct is being extended to preclinical studies in Aotus monkey. We have stay to expand our report on infection blocking immunity and in collaboration with PATH / MVI, we are do mosquito membrane eating assays (MFA). This involves culturing P. falciparum sexual stages in vitro,", "butter_fingers": " acltivty in rabbits; this cunstruct is beiut exteided to preclinkcal studies in Aotus monkeyd. Qe hace continued to expand our studpes on trqnsmmssion blocking mjmunity and ih colneboration with KATH/MVI, we ase performing korqbito membrane feeding assays (MFA). Thif involfed culturing P. salcppwrum sexual stages in vitro,", "random_deletion": "acitivty in rabbits; this construct is being preclinical in Aotus We have continued transmission immunity and in with PATH/MVI, we performing mosquito membrane feeding assays (MFA). involves culturing P. falciparum sexual stages in vitro,", "change_char_case": " acitivty in rabbits; this consTruct is beiNg extEndEd tO pReclInicAl studies in AotUS monKeys. We have continued to eXpand OuR StudIEs On traNsmissiON bLOCkiNg ImMunItY AnD in coLlaBoratioN with PATH/MvI, wE aRe performing MOsQuito membrAne Feeding assayS (MFa). This iNvOlvES cultUriNg P. faLciparUM sexuaL stages in ViTRo,", "whitespace_perturbation": " acitivty in rabbits; this  construct  is b ein g e xt ende d to  preclinical s t udie s in Aotus monkeys. We  have  c o ntin u ed  to e xpand o u rs t udi es  o n t ra n sm issio n b locking  immunityand  i n collaborat i on  with PATH /MV I, we are pe rfo rmingmo squ i to me mbr ane f eeding assays  (MFA). T hi s  invol v es cult u r in g P.  falciparum sexua l  s t ages in vitro, ", "underscore_trick": " acitivty_in rabbits;_this construct is being_extended to_preclinical_studies in_Aotus_monkeys. We have_continued to expand_our studies on transmission_blocking immunity and_in_collaboration with PATH/MVI, we are performing mosquito membrane feeding assays (MFA). This involves culturing_P._falciparum sexual_stages_in_vitro,"}
{"text": "ink, rabbit) in virus interference assays to determine if 9 different X/P-MLV isolates use the same of different receptor determinants in these 4 polymorphic, but fully permissive receptors. Results showed that some viruses produce distinctive species-specific interference profiles that can, in some cases, be correlated with specific receptor sequence variations", "synonym_substitution": "ink, rabbit) in virus interference assays to determine if 9 different X / P - MLV isolates practice the like of unlike receptor determinants in these 4 polymorphic, but in full permissive receptors. Results show that some virus produce distinctive species - specific interference visibility that can, in some cases, be correlated with specific sense organ sequence variations", "butter_fingers": "ink, rabbit) in virus interfevence assays to bwtermiie if 9 siffereng X/P-MLV isolates use the samx of difftgent receptor determivants in nhese 4 pooymocphic, but fully 'srmissiyz recsitors. Cesults showed jhat some visuses produce girtnnctive species-specific interference profilrs that can, in sjme bafes, gv gorrelated with specific receptod sequeice variations", "random_deletion": "ink, rabbit) in virus interference assays to 9 X/P-MLV isolates the same of 4 but fully permissive Results showed that viruses produce distinctive species-specific interference profiles can, in some cases, be correlated with specific receptor sequence variations", "change_char_case": "ink, rabbit) in virus interfereNce assays tO deteRmiNe iF 9 dIffeRent x/P-MLV isolates uSE the Same of different receptoR deteRmINantS In These 4 PolymorPHiC, BUt fUlLy PerMiSSiVe recEptOrs. ResuLts showed tHat SoMe viruses proDUcE distinctiVe sPecies-specifIc iNterfeReNce PRofilEs tHat caN, in somE Cases, bE correlatEd WIth speCIfic recEPToR seqUence variations", "whitespace_perturbation": "ink, rabbit) in virus inte rference a ssays  to  de te rmin e if  9 different X / P-ML V isolates use the sam e ofdi f fere n trecep tor det e rm i n ant sin  th es e  4  poly mor phic, b ut fully p erm is sive recepto r s.  Results s how ed that some  vi rusespr odu c e dis tin ctive  speci e s-spec ific inte rf e rencep rofiles t ha t ca n, in some cases, be correlated wit h spec if i cr e cep tor  sequenceva riati o ns", "underscore_trick": "ink, rabbit)_in virus_interference assays to determine_if 9_different_X/P-MLV isolates_use_the same of_different receptor determinants_in these 4 polymorphic,_but fully permissive_receptors._Results showed that some viruses produce distinctive species-specific interference profiles that can, in some_cases,_be correlated_with_specific_receptor sequence variations"}
{"text": " to dendritic spines in hippocampal CA1 neurons. Stargazin, a member of the transmembrane AMPA receptor regulatory protein family has also been shown to affect the trafficking of GluR1 as well as its kinetics. We are using spectral analysis, FLIM analysis, and anisotropy analysis to investigate the interactions of stargazing", "synonym_substitution": "to dendritic spines in hippocampal CA1 neurons. Stargazin, a member of the transmembrane AMPA receptor regulative protein syndicate has also been shown to involve the trafficking of GluR1 equally well as its kinetics. We are using spectral psychoanalysis, FLIM psychoanalysis, and anisotropy analysis to investigate the interactions of stargazing", "butter_fingers": " to dendritic spines in hipkocampal CA1 neurouw. Starjazin, a member uf the transmembrane AMPA rereptir retulatory protein familh has alsl been syown ro affect vge trafnnckinf of YlnR1 as well as ijs kinetics. Fe are using s[eztxal analysis, FLIM analysis, and anisoeropy amapysis to invesjigatt tre ihnevactions of stargazing", "random_deletion": "to dendritic spines in hippocampal CA1 neurons. member the transmembrane receptor regulatory protein to the trafficking of as well as kinetics. We are using spectral analysis, analysis, and anisotropy analysis to investigate the interactions of stargazing", "change_char_case": " to dendritic spines in hippocAmpal CA1 neuRons. STarGazIn, A memBer oF the transmembrANe AMpA receptor regulatory prOtein FaMIly hAS aLso beEn shown TO aFFEct ThE tRafFiCKiNg of GLuR1 As well aS its kinetiCs. WE aRe using spectRAl Analysis, FLiM aNalysis, and anIsoTropy aNaLysIS to inVesTigatE the inTEractiOns of starGaZIng", "whitespace_perturbation": " to dendritic spines in hi ppocampalCA1 n eur ons .Star gazi n, a member of thetransmembrane AMPA rec eptor  r e gula t or y pro tein fa m il y has  a ls o b ee n  s howntoaffectthe traffi cki ng  of GluR1 as we ll as itskin etics. We ar e u sing s pe ctr a l ana lys is, F LIM an a lysis,  and anis ot r opy an a lysis t o in vest igate the interac t io n s of stargazin g", "underscore_trick": " to_dendritic spines_in hippocampal CA1 neurons._Stargazin, a_member_of the_transmembrane_AMPA receptor regulatory_protein family has_also been shown to_affect the trafficking_of_GluR1 as well as its kinetics. We are using spectral analysis, FLIM analysis, and_anisotropy_analysis to_investigate_the_interactions of stargazing"}
{"text": "-throughput microscopy and image processing to map protein distributions across populations of cells, 2) 3D super-resolution fluorescence imaging methods, 3) super-resolution correlative light and electron microscopy to map proteins at the nanoscale, and 4) high-throughput metal ion FRET methods to map distances within individual proteins at", "synonym_substitution": "-throughput microscopy and image processing to map protein distributions across populations of cells, 2) three-d superintendent - resolution fluorescence imaging methods, 3) superintendent - resolution correlative lighter and electron microscopy to map proteins at the nanoscale, and 4) high - throughput metallic element ion FRET methods to map distances within individual protein at", "butter_fingers": "-thrlughput microscopy and ioage processing to map protejn distrkbutions across populations lf cellw, 2) 3D super-resolution fuuorescenbe imagint meuhods, 3) super-resolnfion covxelatjye liyhv and electron kicroscopy to map proteits ac the nanoscale, and 4) high-throughput ietal ipn FRET methods jo mak dystahbew within individual proteins zt", "random_deletion": "-throughput microscopy and image processing to map across of cells, 3D super-resolution fluorescence light electron microscopy to proteins at the and 4) high-throughput metal ion FRET to map distances within individual proteins at", "change_char_case": "-throughput microscopy and imAge processIng to Map ProTeIn diStriButions across pOPulaTions of cells, 2) 3D super-resoLutioN fLUoreSCeNce imAging meTHoDS, 3) SupEr-ReSolUtIOn CorreLatIve lighT and electrOn mIcRoscopy to map PRoTeins at the NanOscale, and 4) higH-thRoughpUt MetAL ion FrET MethoDs to maP DistanCes within InDIviduaL ProteinS AT", "whitespace_perturbation": "-throughput microscopy and  image pro cessi ngtoma p pr otei n distribution s  acr oss populations of cel ls, 2 )3 D su p er -reso lutionf lu o r esc en ce  im ag i ng  meth ods , 3) su per-resolu tio ncorrelativel ig ht and ele ctr on microscop y t o mappr ote i ns at  th e nan oscale ,  and 4 ) high-th ro u ghputm etal io n FR ET m ethods to map dis t an c es within indi vidual  p r ot e i nsat", "underscore_trick": "-throughput microscopy_and image_processing to map protein_distributions across_populations_of cells,_2)_3D super-resolution fluorescence_imaging methods, 3)_super-resolution correlative light and_electron microscopy to_map_proteins at the nanoscale, and 4) high-throughput metal ion FRET methods to map distances_within_individual proteins_at"}
{"text": " molecular therapeutics intended action on drug target but also to confirm that it is not altering determinants of chemotherapeutic sensitivity for the best available regimens with which it is planned to be combined in Phase I and II trials. In addition, the rapid development, analytical validation of assay performance, SOP-driven validation transfer from the development lab", "synonym_substitution": "molecular therapeutics intended action on drug target but besides to confirm that it is not alter determinants of chemotherapeutic sensitivity for the best available regimen with which it is planned to be combine in Phase I and II trials. In summation, the rapid exploitation, analytical establishment of assay operation, SOP - driven validation transportation from the development lab", "butter_fingers": " mopecular therapeutics inttnded action on dtut targxt but zlso to zonfirm that it is not altermng eeterninants of chemotherapdutic senditivity for rhe best atzilable regimsks wich which it is pkanned to te combined in Pfade I and II trials. In addition, the wapid drvflopment, analyjical dalisation of assay performance, SOP-driben valpdation transfer grom the development lab", "random_deletion": "molecular therapeutics intended action on drug target to that it not altering determinants best regimens with which is planned to combined in Phase I and II In addition, the rapid development, analytical validation of assay performance, SOP-driven validation transfer the development lab", "change_char_case": " molecular therapeutics inteNded action On druG taRgeT bUt alSo to Confirm that it iS Not aLtering determinants of cHemotHeRApeuTIc SensiTivity fOR tHE BesT aVaIlaBlE ReGimenS wiTh which It is planneD to Be Combined in PhASe i and II triaLs. IN addition, the RapId deveLoPmeNT, analYtiCal vaLidatiON of assAy performAnCE, SOP-drIVen valiDATiOn trAnsfer from the deveLOpMEnt lab", "whitespace_perturbation": " molecular therapeutics in tended act ion o n d rug  t arge t bu t also to conf i rm t hat it is not altering  dete rm i nant s  o f che mothera p eu t i c s en si tiv it y  f or th e b est ava ilable reg ime ns  with whichi tis planned  to  be combined  in  Phase  I  an d  II t ria ls. I n addi t ion, t he rapidde v elopme n t, anal y t ic al v alidation of assa y  p e rformance, SOP -drive nv al i d ati ontransfer f ro m the develop m en t l ab", "underscore_trick": " molecular_therapeutics intended_action on drug target_but also_to_confirm that_it_is not altering_determinants of chemotherapeutic_sensitivity for the best_available regimens with_which_it is planned to be combined in Phase I and II trials. In addition,_the_rapid development,_analytical_validation_of assay performance, SOP-driven validation_transfer from the development lab"}
{"text": "-Frederick, which include laboratory-based training in specimen handling, conduct of the assay, and data analysis and reporting by SAIC-Frederick senior scientific staff and lectures on PD assay theory and practice by senior DCTD staff. Via the convergence of DCTD direction and portfolio management with SAIC", "synonym_substitution": "-Frederick, which include laboratory - based training in specimen treatment, behavior of the assay, and data analysis and coverage by SAIC - Frederick senior scientific staff and lecture on PD assay theory and exercise by aged DCTD staff. Via the convergence of DCTD direction and portfolio management with SAIC", "butter_fingers": "-Freferick, which include laburatory-based trcuning mn specjmen hanaling, conduct of the assay, aid dqta abalysis and reporting cy SAIC-Frvderick swnioc scientific stahr and lceturea on 'D assay theory snd practiwe by senior DWTA dtaff. Via the convergence of DCTD dyrectiom wnd portfolio ianabqmenf with SAIC", "random_deletion": "-Frederick, which include laboratory-based training in specimen of assay, and analysis and reporting and on PD assay and practice by DCTD staff. Via the convergence of direction and portfolio management with SAIC", "change_char_case": "-Frederick, which include laboRatory-baseD traiNinG in SpEcimEn haNdling, conduct oF The aSsay, and data analysis and ReporTiNG by SaiC-fredeRick senIOr SCIenTiFiC stAfF AnD lectUreS on PD asSay theory aNd pRaCtice by senioR dCtD staff. Via The Convergence oF DCtD direCtIon ANd porTfoLio maNagemeNT with SaIC", "whitespace_perturbation": "-Frederick, which includelaboratory -base d t rai ni ng i n sp ecimen handlin g , co nduct of the assay, an d dat aa naly s is  andreporti n gb y  SA IC -F red er i ck  seni orscienti fic staffand  l ectures on P D  a ssay theor y a nd practicebysenior  D CTD staff . V ia th e conv e rgence  of DCTDdi r ection and por t f ol io m anagement with SA I C", "underscore_trick": "-Frederick, which_include laboratory-based_training in specimen handling,_conduct of_the_assay, and_data_analysis and reporting_by SAIC-Frederick senior_scientific staff and lectures_on PD assay_theory_and practice by senior DCTD staff. Via the convergence of DCTD direction and portfolio_management_with SAIC"}
{"text": " studies to be performed easily. To measure synaptic plasticity, we use techniques that include whole-cell patch clamp recordings from hippocampal slices maintained in vitro, and stimulate them either electrically or pharmacologically to induce long-term potentiation (LTP) or long-term depression (LTD). To determine how transcription is regulated in", "synonym_substitution": "studies to be performed easily. To measure synaptic malleability, we practice proficiency that include solid - cellular telephone patch clamp recordings from hippocampal slices wield in vitro, and stimulate them either electrically or pharmacologically to induce long - condition potentiation (LTP) or long - term depressive disorder (LTD). To determine how transcription is determine in", "butter_fingers": " stkdies to be performed earily. To measure synaptmc plasficity, wd use techniques that includx while-ceol patch clamp recordivgs from jippocampal woices mainvzined ik vitdl, anb wtimulate them either elactrically or [hxrlacologically to induce long-term poeentiatooj (LTP) or long-tgrm dtprqssikn (LTD). To determine how transcriptjon is gegulated in", "random_deletion": "studies to be performed easily. To measure we techniques that whole-cell patch clamp in and stimulate them electrically or pharmacologically induce long-term potentiation (LTP) or long-term (LTD). To determine how transcription is regulated in", "change_char_case": " studies to be performed easilY. To measure SynapTic PlaStIcitY, we uSe techniques thAT incLude whole-cell patch clamP recoRdINgs fROm HippoCampal sLIcES MaiNtAiNed In VItRo, and StiMulate tHem either eLecTrIcally or pharMAcOlogically To iNduce long-terM poTentiaTiOn (Ltp) or loNg-tErm dePressiON (LTD). To Determine HoW TranscRIption iS REgUlatEd in", "whitespace_perturbation": " studies to be performed e asily. Tomeasu resyn ap ticplas ticity, we use tech niques that include wh ole-c el l  pat c hclamp  record i ng s fro mhi ppo ca m pa l sli ces  mainta ined in vi tro ,and stimulat e  t hem either  el ectrically o r p harmac ol ogi c allytoinduc e long - term p otentiati on (LTP)o r long- t e rm  dep ression (LTD). To de t ermine how tra nscrip ti o ni s  re gul ated in", "underscore_trick": " studies_to be_performed easily. To measure_synaptic plasticity,_we_use techniques_that_include whole-cell patch_clamp recordings from_hippocampal slices maintained in_vitro, and stimulate_them_either electrically or pharmacologically to induce long-term potentiation (LTP) or long-term depression (LTD). To_determine_how transcription_is_regulated_in"}
{"text": " that NDV is very highly attenuated following IN/IT inoculation of rhesus monkeys and AGM. We found that both low-virulence (lentogenic) and intermediate-virulence (mesogenic) strains replicated to similar low titers in non-human primates, suggesting that either backbone should be suitable for human", "synonym_substitution": "that NDV is very highly attenuated following IN / IT inoculation of rhesus monkeys and AGM. We found that both depleted - virulence (lentogenic) and average - virulence (mesogenic) strains replicated to exchangeable humble titers in non - human primates, indicate that either spinal column should be suitable for human", "butter_fingers": " thwt NDV is very highly atuenuated followiny IN/IT mnoculafion of fhesus monkeys and AGM. We fonnd rhat voth low-virulence (lentugenic) anf intermwdiaue-virulence (mesogxhic) strains rsilicacev to similar loe titers it non-human prikaged, suggesting that either backbone srould br duitable for homan", "random_deletion": "that NDV is very highly attenuated following of monkeys and We found that (mesogenic) replicated to similar titers in non-human suggesting that either backbone should be for human", "change_char_case": " that NDV is very highly attenuAted followIng IN/iT iNocUlAtioN of rHesus monkeys anD aGM. WE found that both low-virulEnce (lEnTOgenIC) aNd intErmediaTE-vIRUleNcE (mEsoGeNIc) StraiNs rEplicatEd to similaR loW tIters in non-huMAn Primates, suGgeSting that eitHer BackboNe ShoULd be sUitAble fOr humaN", "whitespace_perturbation": " that NDV is very highly a ttenuatedfollo win g I N/ IT i nocu lation of rhes u s mo nkeys and AGM. We foun d tha tb othl ow -viru lence ( l en t o gen ic )and  i n te rmedi ate -virule nce (mesog eni c)  strains rep l ic ated to si mil ar low titer s i n non- hu man prima tes , sug gestin g  thateither ba ck b one sh o uld bes u it able  for human", "underscore_trick": " that_NDV is_very highly attenuated following_IN/IT inoculation_of_rhesus monkeys_and_AGM. We found_that both low-virulence_(lentogenic) and intermediate-virulence (mesogenic)_strains replicated to_similar_low titers in non-human primates, suggesting that either backbone should be suitable for human"}
{"text": " acid, to mimic phosphorylation, had no effect on the nuclear localization of SAMHD1. Similarly, like the wildtype protein, these SAMHD1 phospho-site mutants were still able to be efficiently degraded by SIVvpx. Interestingly, while neither alanine nor glutamic acid substitutions severely affected SAMHD1 dNT", "synonym_substitution": "acid, to mimic phosphorylation, had no effect on the nuclear localization of SAMHD1. Similarly, like the wildtype protein, these SAMHD1 phospho - site mutant were however able to be efficiently degraded by SIVvpx. Interestingly, while neither alanine nor glutamic acid substitutions severely affect SAMHD1 dNT", "butter_fingers": " acld, to mimic phosphorylatlon, had no effecj in the nuclezr localkzation of SAMHD1. Similarly, lmke rhe wuldtype protein, these RAMHD1 phodpho-site mutents were still egle to nz effjgientnb degraded by SLVvpx. Interastingly, while ndicher alanine nor glutamic acid substytutionx deverely affecjed SSIHD1 sNT", "random_deletion": "acid, to mimic phosphorylation, had no effect nuclear of SAMHD1. like the wildtype were able to be degraded by SIVvpx. while neither alanine nor glutamic acid severely affected SAMHD1 dNT", "change_char_case": " acid, to mimic phosphorylatioN, had no effeCt on tHe nUclEaR locAlizAtion of SAMHD1. SiMIlarLy, like the wildtype proteIn, theSe saMHD1 PHoSpho-sIte mutaNTs WERe sTiLl AblE tO Be EfficIenTly degrAded by SIVvPx. INtErestingly, whILe Neither alaNinE nor glutamic AciD substItUtiONs sevEreLy affEcted SamHD1 dNT", "whitespace_perturbation": " acid, to mimic phosphoryl ation, had  no e ffe cton  the  nuc lear localizat i on o f SAMHD1. Similarly, l ike t he wild t yp e pro tein, t h es e SAM HD 1pho sp h o- sitemut ants we re still a ble  t o be efficie n tl y degraded  by  SIVvpx. Int ere stingl y,  wh i le ne ith er al aninen or glu tamic aci ds ubstit u tions s e v er elyaffected SAMHD1 d N T", "underscore_trick": " acid,_to mimic_phosphorylation, had no effect_on the_nuclear_localization of_SAMHD1._Similarly, like the_wildtype protein, these_SAMHD1 phospho-site mutants were_still able to_be_efficiently degraded by SIVvpx. Interestingly, while neither alanine nor glutamic acid substitutions severely affected_SAMHD1_dNT"}
{"text": "ments and future plans. We performed gene expression profiling of liver samples (normal and tumors) derived from WT (Junfl/fl) and Jun-KO mice. In total, 364 genes were found to be differentially expressed (P&lt;0.01) in tumors derived from Jun-KO vs. WT animals", "synonym_substitution": "ments and future plans. We performed gene expression profiling of liver samples (normal and tumor) derive from WT (Junfl / fl) and Jun - KO mice. In entire, 364 gene were found to be differentially expressed (P&lt;0.01) in tumors derive from Jun - KO vs. WT animals", "butter_fingers": "menhs and future plans. We ptrformed gene exptewsion 'rofilihg of lixer samples (normal and tumord) eerivtb from WT (Junfl/fl) ana Jun-KO mpce. In toral, 364 tenes were found to be djnfereutmally expressed (P&lt;0.01) in tukors derived fsoo Lun-KO vs. WT animals", "random_deletion": "ments and future plans. We performed gene of samples (normal tumors) derived from In 364 genes were to be differentially (P&lt;0.01) in tumors derived from Jun-KO WT animals", "change_char_case": "ments and future plans. We perfOrmed gene eXpresSioN prOfIlinG of lIver samples (norMAl anD tumors) derived from WT (JuNfl/fl) AnD jun-Ko MiCe. In tOtal, 364 genES wERE foUnD tO be DiFFeRentiAllY expresSed (P&lt;0.01) in tuMorS dErived from JuN-kO Vs. WT animalS", "whitespace_perturbation": "ments and future plans. We  performed  gene  ex pre ss ionprof iling of liver samp les (normal and tumors ) der iv e d fr o mWT (J unfl/fl )  a n d  Ju n- KO  mi ce .  I n tot al,  364 ge nes were f oun dto be differ e nt ially expr ess ed (P&lt;0.0 1)in tum or s d e rived  fr om Ju n-KO v s . WT a nimals", "underscore_trick": "ments and_future plans._We performed gene expression_profiling of_liver_samples (normal_and_tumors) derived from_WT (Junfl/fl) and_Jun-KO mice. In total,_364 genes were_found_to be differentially expressed (P&lt;0.01) in tumors derived from Jun-KO vs. WT animals"}
{"text": " sampling of the genetic diversity in Mus. Also, wild mouse species allow us to examine survival strategies in natural populations that harbor virus and to follow the evolution of the resistance genes. These mice additionally provide a source of novel resistance genes and virus variants. One set of projects aims to identify viral and cell receptor determinants responsible for virus", "synonym_substitution": "sampling of the genetic diversity in Mus. Also, wild mouse species leave us to test survival strategies in natural populations that harbor virus and to comply the evolution of the resistance gene. These mice additionally provide a source of fresh underground genes and virus version. One set of projects aim to name viral and cell receptor determinant responsible for virus", "butter_fingers": " salpling of the genetic diyersity in Mus. Also, wilv mouse species allow us to examine survivap wtrattyies in natural popuuations tjat harbir vmrus and to follow the eyjlutjln oy vhe resistance nenes. These mice additiondluy provide a source of novel resistanse genex wnd virus variwnts. Jne avt of projects aims to identify viral end cell receptpr determinants responsiblf fog virus", "random_deletion": "sampling of the genetic diversity in Mus. mouse allow us examine survival strategies virus to follow the of the resistance These mice additionally provide a source novel resistance genes and virus variants. One set of projects aims to identify and cell receptor determinants responsible for virus", "change_char_case": " sampling of the genetic diverSity in Mus. ALso, wiLd mOusE sPeciEs alLow us to examine SUrviVal strategies in natural PopulAtIOns tHAt HarboR virus aND tO FOllOw ThE evOlUTiOn of tHe rEsistanCe genes. TheSe mIcE additionallY PrOvide a sourCe oF novel resistAncE genes AnD viRUs varIanTs. One Set of pROjects Aims to ideNtIFy viraL And cell RECePtor Determinants respoNSiBLe for virus", "whitespace_perturbation": " sampling of the genetic d iversity i n Mus . A lso ,wild  mou se species all o w us  to examine survival s trate gi e s in na tural  popula t io n s  th at  h arb or vi rus a ndto foll ow the evo lut io n of the res i st ance genes . T hese mice ad dit ionall ypro v ide a  so urceof nov e l resi stance ge ne s  and v i rus var i a nt s. O ne set of project s  a i ms to identify  viral  a n dc e llrec eptor dete rm inant s  respon s ib l e for virus", "underscore_trick": " sampling_of the_genetic diversity in Mus._Also, wild_mouse_species allow_us_to examine survival_strategies in natural_populations that harbor virus_and to follow_the_evolution of the resistance genes. These mice additionally provide a source of novel resistance_genes_and virus_variants._One_set of projects aims to_identify viral and cell receptor_determinants responsible_for virus"}
{"text": " with aging. Our study analyzed age-related brain morphometric changes using cortical thickness, cortical gray matter volume, and surface area as morphological indices. It has been previously reported that there are global and regional changes in gray matter volume as we age. Using a surface-based automated reconstruction technique, we analyzed healthy subjects and found", "synonym_substitution": "with aging. Our study analyzed age - relate mind morphometric changes using cortical thickness, cortical gray topic volume, and surface area as morphologic indices. It has been previously reported that there embody global and regional changes in grey matter volume as we senesce. Using a surface - based automated reconstruction technique, we analyzed healthy subject and found", "butter_fingers": " wihh aging. Our study analyeed age-related brcun mor'hometrjc changds using cortical thickness, rortucal tray matter volume, and surface wrea as norpiological indices. It has been lveviobsoy reported thst there ase global and seeilnal changes in gray matter volume ws we abe. Using a surfase-baxqd ahnonated reconstruction techniqus, we anelyzed healthy xubjects and found", "random_deletion": "with aging. Our study analyzed age-related brain using thickness, cortical matter volume, and It been previously reported there are global regional changes in gray matter volume we age. Using a surface-based automated reconstruction technique, we analyzed healthy subjects and", "change_char_case": " with aging. Our study analyzed Age-related Brain MorPhoMeTric ChanGes using corticAL thiCkness, cortical gray mattEr volUmE, And sURfAce arEa as morPHoLOGicAl InDicEs. iT hAs beeN prEviouslY reported tHat ThEre are global ANd Regional chAngEs in gray mattEr vOlume aS wE agE. using A suRface-Based aUTomateD reconstrUcTIon tecHNique, we ANAlYzed Healthy subjects anD FoUNd", "whitespace_perturbation": " with aging. Our study ana lyzed age- relat edbra in  mor phom etric changesu sing  cortical thickness, c ortic al gray ma ttervolume, an d sur fa ce  ar ea as  morp hol ogicalindices. I t h as  been previo u sl y reported  th at there are  gl obal a nd  re g ional  ch anges  in gr a y matt er volume  a s  we ag e . Using a  s urfa ce-based automate d  r e construction t echniq ue ,  w e ana lyz ed healthy  s ubjec t s and f o un d ", "underscore_trick": " with_aging. Our_study analyzed age-related brain_morphometric changes_using_cortical thickness,_cortical_gray matter volume,_and surface area_as morphological indices. It_has been previously_reported_that there are global and regional changes in gray matter volume as we age._Using_a surface-based_automated_reconstruction_technique, we analyzed healthy subjects_and found"}
{"text": " and compared the resulting trans-heterozygote to its congenic control. The mutant strain was much less sensitive to halothane;its concentration-response curve was shifted to the right by more than 60%. When a transgenic copy of Ryr genomic DNA was introduced into the heterozygote, normal halothane sensitivity was", "synonym_substitution": "and compared the resulting trans - heterozygote to its congenic control. The mutant strain was a lot less sensible to halothane;its assiduity - response curve was shifted to the right field by more than 60% . When a transgenic copy of Ryr genomic DNA was introduced into the heterozygote, normal halothane sensitivity was", "butter_fingers": " anf compared the resulting trans-heterozygote to mts confenic covtrol. The mutant strain was luxh lews sensitive to halothxne;its cojcentratuon-rtsponse curve was shifted to ths rigkt by more than 60%. When a trdnsgenic copy mf Rvr genomic DNA was introduced into tre hetetoxygote, normal ralouhage ssnsitivity was", "random_deletion": "and compared the resulting trans-heterozygote to its The strain was less sensitive to to right by more 60%. When a copy of Ryr genomic DNA was into the heterozygote, normal halothane sensitivity was", "change_char_case": " and compared the resulting trAns-heterozYgote To iTs cOnGeniC conTrol. The mutant sTRain Was much less sensitive to HalotHaNE;its COnCentrAtion-reSPoNSE cuRvE wAs sHiFTeD to thE riGht by moRe than 60%. When A trAnSgenic copy of rYr Genomic DNA Was Introduced inTo tHe heteRoZygOTe, norMal HalotHane seNSitiviTy was", "whitespace_perturbation": " and compared the resultin g trans-he teroz ygo teto  its  con genic control. Themutant strain was much  less  s e nsit i ve  to h alothan e ;i t s  co nc en tra ti o n- respo nse  curvewas shifte d t othe right by mo re than 60 %.When a trans gen ic cop yofR yr ge nom ic DN A wasi ntrodu ced intoth e  heter o zygote, n or malhalothane sensiti v it y  was", "underscore_trick": " and_compared the_resulting trans-heterozygote to its_congenic control._The_mutant strain_was_much less sensitive_to halothane;its concentration-response_curve was shifted to_the right by_more_than 60%. When a transgenic copy of Ryr genomic DNA was introduced into the_heterozygote,_normal halothane_sensitivity_was"}
{"text": "WTCe, they were orally gavaged with ETV or CMCP (prepared at a concentration of 0.1 mg/mL in saline) using oral sondes so that the dose administered resulted in 1 mg/kg/day. Just before the administration of ETV, HBV copy numbers in their plasma", "synonym_substitution": "WTCe, they were orally gavaged with ETV or CMCP (prepared at a concentration of 0.1 mg / mL in saline) using oral sondes so that the venereal disease distribute resulted in 1 mg / kg / day. Just before the government of ETV, HBV copy numbers in their plasma", "butter_fingers": "WTCf, they were orally gavagtd with ETV or CMEP (prepered at a concevtration of 0.1 mg/mL in saline) nsint orao sondes so that the duse adminpstered rwsulued in 1 mg/kg/day. Jnat befovz the wdmiuiwtration of ETY, HBV copy tumbers in thehr ppasma", "random_deletion": "WTCe, they were orally gavaged with ETV (prepared a concentration 0.1 mg/mL in that dose administered resulted 1 mg/kg/day. Just the administration of ETV, HBV copy in their plasma", "change_char_case": "WTCe, they were orally gavaged With ETV or CmCP (prEpaRed At A conCentRation of 0.1 mg/mL in SAlinE) using oral sondes so that The doSe ADminIStEred rEsulted IN 1 mG/KG/daY. JUsT beFoRE tHe admIniStratioN of ETV, HBV cOpy NuMbers in their PLaSma", "whitespace_perturbation": "WTCe, they were orally gav aged withETV o r C MCP  ( prep ared  at a concentr a tion  of 0.1 mg/mL in salin e) us in g  ora l  s ondes  so tha t  t h e  do se  a dmi ni s te red r esu lted in  1 mg/kg/d ay.  J ust before t h eadministra tio n of ETV, HB V c opy nu mb ers in th eir  plas ma", "underscore_trick": "WTCe, they_were orally_gavaged with ETV or_CMCP (prepared_at_a concentration_of_0.1 mg/mL in_saline) using oral_sondes so that the_dose administered resulted_in_1 mg/kg/day. Just before the administration of ETV, HBV copy numbers in their plasma"}
{"text": "IM5alpha. Our group aims to characterize the endogenous retroviruses carried in the mouse genome, and the host encoded resistance factors and their viral targets. Our ultimate goal is to describe co-evolutionary patterns of virus-host interactions in natural populations. This work relies heavily on wild mice because laboratory strains provide only a limited", "synonym_substitution": "IM5alpha. Our group aims to characterize the endogenous retroviruses carried in the shiner genome, and the server encoded resistance divisor and their viral prey. Our ultimate goal is to describe co - evolutionary convention of virus - master of ceremonies interactions in natural populations. This work trust heavily on wild mice because laboratory strain provide only a limited", "butter_fingers": "IM5appha. Our group aims to cmaracterize the gneogenons retrkviruses carried in the mouse genome, abd tht host encoded resirtance fabtors and themr viral targets. Our ultliate noal ns to describe cp-evolutiondry patterns ox xixus-host interactions in natural popujations. Tjis work relief hesdily on wild mice because laboratory sfrains krovide only a limoted", "random_deletion": "IM5alpha. Our group aims to characterize the carried the mouse and the host viral Our ultimate goal to describe co-evolutionary of virus-host interactions in natural populations. work relies heavily on wild mice because laboratory strains provide only a limited", "change_char_case": "IM5alpha. Our group aims to charActerize thE endoGenOus ReTrovIrusEs carried in the MOuse Genome, and the host encodeD resiStANce fACtOrs anD their vIRaL TArgEtS. OUr uLtIMaTe goaL is To descrIbe co-evoluTioNaRy patterns of VIrUs-host inteRacTions in naturAl pOpulatIoNs. THIs worK reLies hEavily ON wild mIce becausE lABoratoRY strainS PRoVide Only a limited", "whitespace_perturbation": "IM5alpha. Our group aims t o characte rizethe  en do geno us r etroviruses ca r ried  in the mouse genome,and t he host en coded  resist a nc e fac to rs  an dt he ir vi ral  target s. Our ult ima te  goal is tod es cribe co-e vol utionary pat ter ns ofvi rus - hostint eract ions i n  natur al popula ti o ns. Th i s workr e li es h eavily on wild mi c eb ecause laborat ory st ra i ns p rov ide  only a li mi ted", "underscore_trick": "IM5alpha. Our_group aims_to characterize the endogenous_retroviruses carried_in_the mouse_genome,_and the host_encoded resistance factors_and their viral targets._Our ultimate goal_is_to describe co-evolutionary patterns of virus-host interactions in natural populations. This work relies heavily_on_wild mice_because_laboratory_strains provide only a limited"}
{"text": " or necrosis, and the high-value payoff of adapting as many validated PD assays as possible to the customized use of the Veridex platform instrumentation to isolate circulating tumor cells. During this past year (2011-2012) our laboratory built upon the foundation begun in 2008 to explore the interface between the malaria parasite and the", "synonym_substitution": "or necrosis, and the high - value payoff of adapting as many validate palladium assays as possible to the custom-make consumption of the Veridex platform instrumentation to sequester circulating tumor cells. During this past year (2011 - 2012) our lab built upon the foundation begin in 2008 to explore the interface between the malaria parasite and the", "butter_fingers": " or necrosis, and the high-vauue payoff of abqpting as mahy validxted PD assays as possible tl rhe cystomized use of the Vdridex plwtform ibstrnmentation to isolate civeulatjkg tukir cells. Durinn this past year (2011-2012) our labmrxtlry built upon the foundation begun in 2008 to edplore the intgrfact bqtwesn the malaria parasite and the", "random_deletion": "or necrosis, and the high-value payoff of many PD assays possible to the platform to isolate circulating cells. During this year (2011-2012) our laboratory built upon foundation begun in 2008 to explore the interface between the malaria parasite and", "change_char_case": " or necrosis, and the high-value Payoff of adAptinG as ManY vAlidAted pD assays as possIBle tO the customized use of the veridEx PLatfORm InstrUmentatIOn TO IsoLaTe CirCuLAtIng tuMor Cells. DuRing this paSt yEaR (2011-2012) our laboratoRY bUilt upon thE foUndation beguN in 2008 To explOrE thE InterFacE betwEen the MAlaria Parasite aNd THe", "whitespace_perturbation": " or necrosis, and the high -value pay off o f a dap ti ng a s ma ny validated P D  ass ays as possible to the  cust om i zedu se  of t he Veri d ex p lat fo rm  in st r um entat ion  to iso late circu lat in g tumor cell s .During thi s p ast year (20 11- 2012)ou r l a borat ory  buil t upon the fo undationbe g un in2 008 toe x pl orethe interface bet w ee n  the malaria p arasit ea nd t he", "underscore_trick": " or_necrosis, and_the high-value payoff of_adapting as_many_validated PD_assays_as possible to_the customized use_of the Veridex platform_instrumentation to isolate_circulating_tumor cells. During this past year (2011-2012) our laboratory built upon the foundation begun_in_2008 to_explore_the_interface between the malaria parasite_and the"}
{"text": " and LGR5(low), in the ACECs and more advanced extraepithelial tumor nests. This expression pattern resembled that of reserve EC cells that express reserve ISC genes; most reside at the +4 position in normal crypts. The presence of multifocal ACECs from separate tumors and in the macroscopic tumor-free", "synonym_substitution": "and LGR5(low), in the ACECs and more advanced extraepithelial tumor nests. This expression pattern resemble that of reservation EC cells that express reservation ISC gene; most reside at the +4 position in normal crypts. The bearing of multifocal ACECs from disjoined tumors and in the macroscopic tumor - complimentary", "butter_fingers": " anf LGR5(low), in the ACECs ana more advanced extrae'ithelizl tumor nests. This expression pattecn rwsemboed that of reserve EC cells thwt exprews rtserve ISC genes; most reslbe at bhe +4 'owition in normsl crypts. Dhe presence ox ouptifocal ACECs from separate tumors and in tje macroscopic tumpw-fres", "random_deletion": "and LGR5(low), in the ACECs and more tumor This expression resembled that of reserve genes; most reside the +4 position normal crypts. The presence of multifocal from separate tumors and in the macroscopic tumor-free", "change_char_case": " and LGR5(low), in the ACECs and morE advanced eXtraePitHelIaL tumOr neSts. This expressIOn paTtern resembled that of reServe eC CElls THaT exprEss reseRVe isc geNeS; mOst ReSIdE at thE +4 poSition iN normal cryPts. thE presence of mULtIfocal ACECS frOm separate tuMorS and in ThE maCRoscoPic Tumor-Free", "whitespace_perturbation": " and LGR5(low), in the ACE Cs and mor e adv anc edex trae pith elial tumor ne s ts.This expression patter n res em b ledt ha t ofreserve EC c ell sth atex p re ss re ser ve ISCgenes; mos t r es ide at the + 4  p osition in  no rmal crypts.  Th e pres en ceo f mul tif ocalACECsf rom se parate tu mo r s andi n the m a c ro scop ic tumor-free", "underscore_trick": " and_LGR5(low), in_the ACECs and more_advanced extraepithelial_tumor_nests. This_expression_pattern resembled that_of reserve EC_cells that express reserve_ISC genes; most_reside_at the +4 position in normal crypts. The presence of multifocal ACECs from separate_tumors_and in_the_macroscopic_tumor-free"}
{"text": " bond or methylidene in the 4' position of the cyclopentyl moiety. To determine whether CMCP reduces the amount of intracellular HBVWT DNA in HepG2.2.2.15.7 cells, DNA isolated from HepG2.2.2.15.7 cells, which were cultured in the", "synonym_substitution": "bond or methylidene in the 4' position of the cyclopentyl moiety. To determine whether CMCP reduces the sum of intracellular HBVWT DNA in HepG2.2.2.15.7 cell, DNA isolated from HepG2.2.2.15.7 cells, which were culture in the", "butter_fingers": " bojd or methylidene in the 4' position of tkw cyclmpentym moiety. To determine whether CMCP rxducws tht amount of intraceulular HBNWT DNA ib HekG2.2.2.15.7 cells, DNA isolefed from HepG2.2.2.15.7 gells, xhich were cultored in the", "random_deletion": "bond or methylidene in the 4' position cyclopentyl To determine CMCP reduces the in cells, DNA isolated HepG2.2.2.15.7 cells, which cultured in the", "change_char_case": " bond or methylidene in the 4' posItion of the CycloPenTyl MoIety. to deTermine whether cmCP rEduces the amount of intraCelluLaR hBVWt dNa in HePG2.2.2.15.7 cells, dnA ISOlaTeD fRom hePg2.2.2.15.7 cElls, wHicH were cuLtured in thE", "whitespace_perturbation": " bond or methylidene in th e 4' posit ion o f t hecy clop enty l moiety. To d e term ine whether CMCP reduc es th ea moun t  o f int racellu l ar H BVW TDN A i nH ep G2.2. 2.1 5.7 cel ls, DNA is ola te d from HepG2 . 2. 2.15.7 cel ls,  which werecul turedin  th e ", "underscore_trick": " bond_or methylidene_in the 4' position_of the_cyclopentyl_moiety. To_determine_whether CMCP reduces_the amount of_intracellular HBVWT DNA in_HepG2.2.2.15.7 cells, DNA_isolated_from HepG2.2.2.15.7 cells, which were cultured in the"}
{"text": " ability to consume large quantities of palatable foods, especially when coupled with decreased subsequent satiety, may play a role in the greater weight gain found in binge eating children. Two protocols have examined efficacy of interpersonal therapy (IPT) as a weight gain preventive strategy among children and adolescents who report binge eating behaviors (", "synonym_substitution": "ability to consume large quantities of palatable foods, particularly when pair with decreased subsequent satiety, may play a character in the greater weight addition found in binge eat children. Two protocols have examine efficacy of interpersonal therapy (IPT) as a weight gain preventive scheme among children and adolescents who report binge eating behaviors (", "butter_fingers": " abllity to consume large qmantities of palcrable hoods, eapeciallh when coupled with decreasev suvsequtut satiety, may play x role in the greqter qeight gaii found lu binfc eatnnj children. Two krotocols haee examined efxizaey of interpersonal therapy (IPT) as a weight gwin preventive strseegy among children and adolescents whk reporu binge eating behsviors (", "random_deletion": "ability to consume large quantities of palatable when with decreased satiety, may play weight found in binge children. Two protocols examined efficacy of interpersonal therapy (IPT) a weight gain preventive strategy among children and adolescents who report binge eating (", "change_char_case": " ability to consume large quanTities of paLatabLe fOodS, eSpecIallY when coupled wiTH decReased subsequent satietY, may pLaY A rolE In The grEater weIGhT GAin FoUnD in BiNGe EatinG chIldren. TWo protocolS haVe Examined effiCAcY of interpeRsoNal therapy (IPt) as A weighT gAin PRevenTivE straTegy amONg chilDren and adOlEScents WHo reporT BInGe eaTing behaviors (", "whitespace_perturbation": " ability to consume largequantities  of p ala tab le  foo ds,especially whe n  cou pled with decreased su bsequ en t  sat i et y, ma y playa  r o l e i nth e g re a te r wei ght  gain f ound in bi nge  e ating childr e n.  Two proto col s have exami ned  effic ac y o f  inte rpe rsona l ther a py (IP T) as a w ei g ht gai n  preven t i ve  str ategy among child r en and adolescent s whore p or t bin geeating beh av iors( ", "underscore_trick": " ability_to consume_large quantities of palatable_foods, especially_when_coupled with_decreased_subsequent satiety, may_play a role_in the greater weight_gain found in_binge_eating children. Two protocols have examined efficacy of interpersonal therapy (IPT) as a weight_gain_preventive strategy_among_children_and adolescents who report binge_eating behaviors ("}
{"text": " retrieval. First, using our high-throughput TIRF imaging pipeline discussed above we mapped how over 80 proteins associated with endocytic clathrin-coated structures in PC12 cells. This provided us with the fundamental protein signature of clathrin structure across the plasma membrane. From this analysis we determined that a core group", "synonym_substitution": "retrieval. First, using our high - throughput TIRF imagination grapevine hash out above we mapped how over 80 protein associated with endocytic clathrin - coat structures in PC12 cellular telephone. This provided us with the fundamental protein touch of clathrin structure across the plasma membrane. From this analysis we specify that a core group", "butter_fingers": " rehrieval. First, using our migh-throughput TNEF imajing pileline dkscussed above we mapped how ocer 80 kgoteins associated wigh endocynic clathein-ciqted strucvhres in PC12 cemps. Tkiw provided us eith the fgndamental prodekn signature of clathrin structure acwoss thr olasma membrang. Frok thia analysis we determined that a code grouk", "random_deletion": "retrieval. First, using our high-throughput TIRF imaging above mapped how 80 proteins associated PC12 This provided us the fundamental protein of clathrin structure across the plasma From this analysis we determined that a core group", "change_char_case": " retrieval. First, using our higH-throughpuT TIRF ImaGinG pIpelIne dIscussed above wE MappEd how over 80 proteins assocIated WiTH endOCyTic clAthrin-cOAtED StrUcTuRes In pc12 cElls. THis ProvideD us with the FunDaMental proteiN SiGnature of cLatHrin structurE acRoss thE pLasMA membRanE. From This anALysis wE determinEd THat a coRE group", "whitespace_perturbation": " retrieval. First, using o ur high-th rough put  TI RF  ima ging  pipeline disc u ssed  above we mapped how o ver 8 0p rote i ns  asso ciatedw it h end oc yt iccl a th rin-c oat ed stru ctures inPC1 2cells. Thisp ro vided us w ith  the fundame nta l prot ei n s i gnatu reof cl athrin struct ure acros st he pla s ma memb r a ne . Fr om this analysisw ed etermined that  a cor eg ro u p ", "underscore_trick": " retrieval._First, using_our high-throughput TIRF imaging_pipeline discussed_above_we mapped_how_over 80 proteins_associated with endocytic_clathrin-coated structures in PC12_cells. This provided_us_with the fundamental protein signature of clathrin structure across the plasma membrane. From this_analysis_we determined_that_a_core group"}
{"text": " renewal of the application rifled \"ACTIVE Phase II: UAB Field Site\". This application is for the Field Site at the University of Alabama at Birmingham. Phase I of ACTIVE (Advanced Cognitive Training for Independent and Vital Elderly) was a randomized controlled trial of three cognitive intervention arms, addressing the question of", "synonym_substitution": "renewal of the application rifled \" ACTIVE Phase II: UAB Field Site \". This application is for the Field Site at the University of Alabama at Birmingham. Phase I of ACTIVE (Advanced Cognitive Training for Independent and Vital Elderly) was a randomize operate trial of three cognitive intervention arm, address the question of", "butter_fingers": " rejewal of the application rifled \"ACTIVE Khqse II: UAB Fjeld Sitd\". This application is for thx Fiwld Sute at the University uf Alabamw at Birningiam. Phase I of ARFIVE (Adycnced Gognicite Training for Independett and Vital Enddrpy) was a randomized controlled triaj of thtef cognitive injervemeion arms, addressing the question of", "random_deletion": "renewal of the application rifled \"ACTIVE Phase Field This application for the Field Alabama Birmingham. Phase I ACTIVE (Advanced Cognitive for Independent and Vital Elderly) was randomized controlled trial of three cognitive intervention arms, addressing the question of", "change_char_case": " renewal of the application riFled \"ACTIVE phase iI: UaB FIeLd SiTe\". ThIs application iS For tHe Field Site at the UniverSity oF ALAbamA At birmiNgham. PhASe i OF ACtIvE (advAnCEd cogniTivE TrainiNg for IndepEndEnT and Vital EldERlY) was a randoMizEd controlled TriAl of thReE coGNitivE inTerveNtion aRMs, addrEssing the QuEStion oF", "whitespace_perturbation": " renewal of the applicatio n rifled \" ACTIV E P has eII:UABField Site\". T h is a pplication is for theField  S i te a t  t he Un iversit y  o f Ala ba ma  at  B i rm ingha m.Phase I  of ACTIVE  (A dv anced Cognit i ve  Trainingfor  Independent  an d Vita lEld e rly)was  a ra ndomiz e d cont rolled tr ia l  of th r ee cogn i t iv e in tervention arms,a dd r essing the que stionof ", "underscore_trick": " renewal_of the_application rifled \"ACTIVE Phase_II: UAB_Field_Site\". This_application_is for the_Field Site at_the University of Alabama_at Birmingham. Phase_I_of ACTIVE (Advanced Cognitive Training for Independent and Vital Elderly) was a randomized controlled_trial_of three_cognitive_intervention_arms, addressing the question of"}
{"text": " of hematologic function and exposure to TCDD in Vietnam War veterans of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of herbicides that were contaminated with TCDD. A comparison group of Air Force veterans who served in Southeast Asia during the same period and who were not involved with spraying herbicides", "synonym_substitution": "of hematologic function and exposure to TCDD in Vietnam War veterans of Operation Ranch Hand, the Air Force unit creditworthy for the aeriform spray of herbicides that were pollute with TCDD. A comparison group of Air Force veteran who served in Southeast Asia during the same menstruation and who were not necessitate with spraying herbicide", "butter_fingers": " of hematologic function ana exposure to TEED in Tietnam War vetdrans of Operation Ranch Hanv, thw Air Force unit responsibld for the aerial wprabing of herbicidxa that were ckktamiuaved with TCDD. A comparisot group of Air Furee veterans who served in Southeast Wsia dutijg the same petiod sgd wgo were not involved with spraying herbicpdes", "random_deletion": "of hematologic function and exposure to TCDD War of Operation Hand, the Air aerial of herbicides that contaminated with TCDD. comparison group of Air Force veterans served in Southeast Asia during the same period and who were not involved spraying herbicides", "change_char_case": " of hematologic function and eXposure to TcDD in vieTnaM WAr veTeraNs of Operation RANch HAnd, the Air Force unit respOnsibLe FOr thE AeRial sPraying OF hERBicIdEs ThaT wERe ContaMinAted witH TCDD. A compAriSoN group of Air FORcE veterans wHo sErved in SouthEasT Asia dUrIng THe samE peRiod aNd who wERe not iNvolved wiTh SPrayinG HerbiciDES", "whitespace_perturbation": " of hematologic function a nd exposur e toTCD D i nViet namWar veterans o f  Ope ration Ranch Hand, the  AirFo r ce u n it  resp onsible fo r the  a er ial  s p ra yingofherbici des that w ere  c ontaminatedw it h TCDD. Acom parison grou p o f AirFo rce veter ans  whoserved in Sou theast As ia during the sam e pe riod  and who were not in v olved with spr ayinghe r bi c i des ", "underscore_trick": " of_hematologic function_and exposure to TCDD_in Vietnam_War_veterans of_Operation_Ranch Hand, the_Air Force unit_responsible for the aerial_spraying of herbicides_that_were contaminated with TCDD. A comparison group of Air Force veterans who served in_Southeast_Asia during_the_same_period and who were not_involved with spraying herbicides"}
{"text": " in guinea pigs against an adapted strain of EBOV. A single IN/IT inoculation of rhesus monkeys was moderately immunogenic against EBOV and protected 88% of the animals against severe hemorrhagic fever and death caused by EBOV challenge. Two doses were highly immunogenic and all of the animals were free of disease", "synonym_substitution": "in guinea pigs against an adapted strain of EBOV. A single IN / IT inoculation of rhesus monkey was reasonably immunogenic against EBOV and protected 88% of the animals against dangerous hemorrhagic fever and end caused by EBOV challenge. Two doses were highly immunogenic and all of the animals were complimentary of disease", "butter_fingers": " in guinea pigs against an xdapted strain of EBOV. A sinfle IN/IT inoculation of rhesus monkebs wqs moeerately immunogenic aeainst EBLV and peoterted 88% of the animals agalust ssyere kenorrhagic fevet and death waused by EBOV cfaplenge. Two doses were highly immunodenic amd all of the anymalx wers free of disease", "random_deletion": "in guinea pigs against an adapted strain A IN/IT inoculation rhesus monkeys was protected of the animals severe hemorrhagic fever death caused by EBOV challenge. Two were highly immunogenic and all of the animals were free of disease", "change_char_case": " in guinea pigs against an adapTed strain oF EBOV. a siNglE In/IT iNocuLation of rhesus MOnkeYs was moderately immunogEnic aGaINst EboV And prOtected 88% OF tHE AniMaLs AgaInST sEvere HemOrrhagiC fever and dEatH cAused by EBOV cHAlLenge. Two doSes Were highly imMunOgenic AnD alL Of the AniMals wEre freE Of diseAse", "whitespace_perturbation": " in guinea pigs against an  adapted s train  of  EB OV . Asing le IN/IT inocu l atio n of rhesus monkeys wa s mod er a tely im munog enic ag a in s t  EB OV  a ndpr o te cted88%  of the  animals a gai ns t severe hem o rr hagic feve r a nd death cau sed  by EB OV  ch a lleng e.Two d oses w e re hig hly immun og e nic an d  all of t he  ani mals were free of di s ease", "underscore_trick": " in_guinea pigs_against an adapted strain_of EBOV._A_single IN/IT_inoculation_of rhesus monkeys_was moderately immunogenic_against EBOV and protected_88% of the_animals_against severe hemorrhagic fever and death caused by EBOV challenge. Two doses were highly_immunogenic_and all_of_the_animals were free of disease"}
{"text": "NRG1 x ErbB4 x AKT1) was validated using fMRI in controls carrying the risk SNPs and all were found to be inefficient in DLPFC processing. Our data suggest complex epistatic effects implicating a NRG1 molecular pathway in cognitive function and pathogenesis of SZ. Another study, explored the", "synonym_substitution": "NRG1 x ErbB4 x AKT1) was validated using fMRI in controls carrying the hazard single nucleotide polymorphism and all were find to be ineffective in DLPFC processing. Our data hint complex epistatic effects implicate a NRG1 molecular pathway in cognitive function and pathogenesis of SZ. Another survey, explored the", "butter_fingers": "NRG1 x ErbB4 x AKT1) was validaued using fMRI in controns cardying thd risk SNPs and all were fouid ti be unefficient in DLPFC pfocessing. Our datq sujgest complex epmatatic cyfecta impnmcating a NRG1 mplecular pdthway in cognhtkvz function and pathogenesis of SZ. Anjther syufy, explored thg", "random_deletion": "NRG1 x ErbB4 x AKT1) was validated in carrying the SNPs and all in processing. Our data complex epistatic effects a NRG1 molecular pathway in cognitive and pathogenesis of SZ. Another study, explored the", "change_char_case": "NRG1 x ErbB4 x AKT1) was validated uSing fMRI in ContrOls CarRyIng tHe riSk SNPs and all weRE fouNd to be inefficient in DLPfC proCeSSing. oUr Data sUggest cOMpLEX epIsTaTic EfFEcTs impLicAting a NrG1 moleculaR paThWay in cognitiVE fUnction and PatHogenesis of Sz. AnOther sTuDy, eXPloreD thE", "whitespace_perturbation": "NRG1 x ErbB4 x AKT1) was v alidated u singfMR I i ncont rols  carrying ther iskSNPs and all were foun d tobe inef f ic ientin DLPF C  p r o ces si ng . O ur da ta su gge st comp lex epista tic  e ffects impli c at ing a NRG1  mo lecular path way  in co gn iti v e fun cti on an d path o genesi s of SZ.An o ther s t udy, ex p l or ed t he", "underscore_trick": "NRG1 x_ErbB4 x_AKT1) was validated using_fMRI in_controls_carrying the_risk_SNPs and all_were found to_be inefficient in DLPFC_processing. Our data_suggest_complex epistatic effects implicating a NRG1 molecular pathway in cognitive function and pathogenesis of_SZ._Another study,_explored_the"}
{"text": "-RA181T/N236T, giving IC50 values of 177, 406, and 218, respectively. CMCP also effectively blocked the synthesis of HBVWTCe and HBVADV-RA181T/N236T DNA with the IC50 values of 206 and 96 nM, respectively, and it fairly", "synonym_substitution": "-RA181T / N236 T, giving IC50 values of 177, 406, and 218, respectively. CMCP also effectively stop the deduction of HBVWTCe and HBVADV - RA181T / N236 T DNA with the IC50 values of 206 and 96 nM, respectively, and it fairly", "butter_fingers": "-RA181T/J236T, giving IC50 values of 177, 406, and 218, respectivglt. CMCP also sffectivdly blocked the synthesis of HVVWTCt and HBVADV-RA181T/N236T DVA with tje IC50 vaoues if 206 and 96 nM, respecbnvely, wnd nt fairly", "random_deletion": "-RA181T/N236T, giving IC50 values of 177, 406, respectively. also effectively the synthesis of the values of 206 96 nM, respectively, it fairly", "change_char_case": "-RA181T/N236T, giving IC50 values of 177, 406, and 218, rEspectivelY. CMCP AlsO efFeCtivEly bLocked the synthESis oF HBVWTCe and HBVADV-RA181T/N236T dNA wiTh THe IC50 VAlUes of 206 And 96 nM, reSPeCTIveLy, AnD it FaIRlY", "whitespace_perturbation": "-RA181T/N236T, giving IC50  values of  177,  40 6,an d 21 8, r espectively. C M CP a lso effectively blocke d the  s y nthe s is  of H BVWTCea nd H BVA DV -R A18 1T / N2 36T D NAwith th e IC50 val ues  o f 206 and 96 nM , respecti vel y, and it fa irl y", "underscore_trick": "-RA181T/N236T, giving_IC50 values_of 177, 406, and_218, respectively._CMCP_also effectively_blocked_the synthesis of_HBVWTCe and HBVADV-RA181T/N236T_DNA with the IC50_values of 206_and_96 nM, respectively, and it fairly"}
{"text": "1 shedding may involve the zinc metalloprotease-dependent trafficking of intracytoplasmic TNFR1 vesicles to the cell surface. These findings identify new roles for the proteasome and zinc metalloproteases in regulating the proteolytic cleavage and shedding of the TNFR1 extracellular domain. In addition, the ability of proteasome inhibition to induce", "synonym_substitution": "1 shedding may involve the zinc metalloprotease - dependent trafficking of intracytoplasmic TNFR1 vesicles to the cell open. These finding identify new roles for the proteasome and zinc metalloproteases in regulate the proteolytic cleavage and shedding of the TNFR1 extracellular domain. In summation, the ability of proteasome prohibition to induce", "butter_fingers": "1 shfdding may involve the zlnc metalloprotecwe-depeident tdaffickivg of intracytoplasmic TNFR1 tesixles uj the cell surface. These fijdings ieentmfy new roles foc the proteasojc and vinc metalloprojeases in reculating the psogellytic cleavage and shedding of the TNFR1 ectgacellular domwin. Pn addjniin, the ability of proteasome jnhibitpon to induce", "random_deletion": "1 shedding may involve the zinc metalloprotease-dependent intracytoplasmic vesicles to cell surface. These the and zinc metalloproteases regulating the proteolytic and shedding of the TNFR1 extracellular In addition, the ability of proteasome inhibition to induce", "change_char_case": "1 shedding may involve the zinc MetalloproTease-DepEndEnT traFficKing of intracytOPlasMic TNFR1 vesicles to the ceLl surFaCE. TheSE fIndinGs identIFy NEW roLeS fOr tHe PRoTeasoMe aNd zinc mEtalloprotEasEs In regulating THe ProteolytiC clEavage and sheDdiNg of thE TnFR1 EXtracEllUlar dOmain. IN AdditiOn, the abilItY Of protEAsome inHIBiTion To induce", "whitespace_perturbation": "1 shedding may involve the  zinc meta llopr ote ase -d epen dent  trafficking o f  int racytoplasmic TNFR1 ve sicle st o th e  c ell s urface. Th e s e f in di ngs  i d en tifynew  rolesfor the pr ote as ome and zinc me talloprote ase s in regulat ing  the p ro teo l yticcle avage  and s h edding  of the T NF R 1 extr a cellula r do main . In addition, th e  a b ility of prote asomein h ib i t ion  to  induce", "underscore_trick": "1 shedding_may involve_the zinc metalloprotease-dependent trafficking_of intracytoplasmic_TNFR1_vesicles to_the_cell surface. These_findings identify new_roles for the proteasome_and zinc metalloproteases_in_regulating the proteolytic cleavage and shedding of the TNFR1 extracellular domain. In addition, the_ability_of proteasome_inhibition_to_induce"}
{"text": " turned up one (c522) that provides substantial rescue of the halothane phenotype, suggesting that arousal depends on localized circuitry. However, channel expression under the control of c522 fails to rescue the sevoflurane phenotypes of na mutants. This result not only proves that the halothane rescue is not the result", "synonym_substitution": "turned up one (c522) that provides substantial rescue of the halothane phenotype, suggesting that foreplay depend on localized circuitry. However, channel formula under the dominance of c522 fails to rescue the sevoflurane phenotypes of na mutant. This solution not only proves that the halothane rescue is not the result", "butter_fingers": " tugned up one (c522) that proviaes substantial rescue of ths halothxne phenotype, suggesting thav ariusal depends on localized zircuitry. However, chainel expression nhder thc confvol oy r522 fails to rescoe the sevofnurane phenoty[er lf na mutants. This result not only [roves yhwt the halothage rtscte ia not the result", "random_deletion": "turned up one (c522) that provides substantial the phenotype, suggesting arousal depends on under control of c522 to rescue the phenotypes of na mutants. This result only proves that the halothane rescue is not the result", "change_char_case": " turned up one (c522) that provides sUbstantial RescuE of The HaLothAne pHenotype, suggesTIng tHat arousal depends on locAlizeD cIRcuiTRy. howevEr, channEL eXPResSiOn UndEr THe ContrOl oF c522 fails To rescue thE seVoFlurane phenoTYpEs of na mutaNts. this result noT onLy provEs ThaT The haLotHane rEscue iS Not the Result", "whitespace_perturbation": " turned up one (c522) that  providessubst ant ial  r escu e of  the halothane phen otype, suggesting that  arou sa l  dep e nd s onlocaliz e dc i rcu it ry . H ow e ve r, ch ann el expr ession und erth e control of c5 22 fails t o r escue the se vof lurane  p hen o types  of  na m utants .  Thisresult no to nly pr o ves tha t th e ha lothane rescue is no t  the result", "underscore_trick": " turned_up one_(c522) that provides substantial_rescue of_the_halothane phenotype,_suggesting_that arousal depends_on localized circuitry._However, channel expression under_the control of_c522_fails to rescue the sevoflurane phenotypes of na mutants. This result not only proves_that_the halothane_rescue_is_not the result"}
{"text": " proteins translated from alternatively spliced mRNAs. We have recently demonstrated that proteasome inhibition induces the proteolytic cleavage and shedding of soluble TNFR1 ectodomains from human pulmonary epithelial cells, which is associated with a reduction of intracytoplasmic TNFR1 vesicles and cell surface receptors. Furtherthemore, the mechanism of TNFR", "synonym_substitution": "proteins translated from alternatively spliced mRNAs. We have recently attest that proteasome prohibition induces the proteolytic cleavage and shedding of soluble TNFR1 ectodomains from human pneumonic epithelial cells, which is consort with a reduction of intracytoplasmic TNFR1 vesicle and cellular telephone surface receptors. Furtherthemore, the mechanism of TNFR", "butter_fingers": " prlteins translated from auternatively spliced mCNAs. We have rezently demonstrated that proveasime ibhibition induces the oroteolytpc cleavate aid shedding of soluble TKYR1 ecfldomciis from human polmonary epidhelial cells, fhkck is associated with a reduction of yntracyyoolasmic TNFR1 vgsiclts wnd dvlo surface receptors. Furtherthsmore, tie mechanism of TNFR", "random_deletion": "proteins translated from alternatively spliced mRNAs. We demonstrated proteasome inhibition the proteolytic cleavage ectodomains human pulmonary epithelial which is associated a reduction of intracytoplasmic TNFR1 vesicles cell surface receptors. Furtherthemore, the mechanism of TNFR", "change_char_case": " proteins translated from altErnatively SplicEd mrNAS. WE havE recEntly demonstraTEd thAt proteasome inhibition InducEs THe prOTeOlytiC cleavaGE aND SheDdInG of SoLUbLe TNFr1 ecTodomaiNs from humaN puLmOnary epithelIAl Cells, which Is aSsociated witH a rEductiOn Of iNTracyTopLasmiC TNFR1 vESicles And cell suRfACe recePTors. FurTHErThemOre, the mechanism of tnFr", "whitespace_perturbation": " proteins translated fromalternativ ely s pli ced  m RNAs . We  have recently demo nstrated that proteaso me in hi b itio n  i nduce s the p r ot e o lyt ic  c lea va g eand s hed ding of  soluble T NFR 1ectodomainsf ro m human pu lmo nary epithel ial  cells ,whi c h isass ociat ed wit h  a red uction of  i n tracyt o plasmic T NF R1 v esicles and cells ur f ace receptors.  Furth er t he m o re,  th e mechanis mof TN F R", "underscore_trick": " proteins_translated from_alternatively spliced mRNAs. We_have recently_demonstrated_that proteasome_inhibition_induces the proteolytic_cleavage and shedding_of soluble TNFR1 ectodomains_from human pulmonary_epithelial_cells, which is associated with a reduction of intracytoplasmic TNFR1 vesicles and cell surface_receptors._Furtherthemore, the_mechanism_of_TNFR"}
{"text": " using approved therapeutics in the treatment of these children to obtain answers to the underlying immune dysregulatory defect. CONCLUSIONS AND SIGNIFICANCE 1. In now 2 severe autoinflammatory syndromes, cryopyrin associated periodic syndromes, CAPS (which includes FACS, MWS and NOMID), and deficiency of the", "synonym_substitution": "using approved therapeutics in the treatment of these child to receive answers to the underlying immune dysregulatory defect. conclusion AND SIGNIFICANCE 1. In now 2 hard autoinflammatory syndromes, cryopyrin associated periodic syndrome, CAPS (which includes FACS, MWS and NOMID), and deficiency of the", "butter_fingers": " uslng approved therapeuticr in the treatmgnr of tiese chjldren tu obtain answers to the undeclyibg imnune dysregulatory defdct. CONCLLSIONS ANE SIJNIFICANCE 1. In now 2 sevevz autklnflaknatory syndromgs, cryopyrin associated pesiudnc syndromes, CAPS (which includes FACF, MWS amd NOMID), and defyciemsy or the", "random_deletion": "using approved therapeutics in the treatment of to answers to underlying immune dysregulatory In 2 severe autoinflammatory cryopyrin associated periodic CAPS (which includes FACS, MWS and and deficiency of the", "change_char_case": " using approved therapeutics In the treatMent oF thEse ChIldrEn to Obtain answers tO The uNderlying immune dysreguLatorY dEFect. coNcLUSIoNS AND SigNifiCAnCe 1. IN noW 2 sEVeRe autOinFlammatOry syndromEs, cRyOpyrin associATeD periodic sYndRomes, CAPS (whiCh iNcludeS FaCS, mwS and nOMiD), and DeficiENcy of tHe", "whitespace_perturbation": " using approved therapeuti cs in thetreat men t o fthes e ch ildren to obta i n an swers to the underlyin g imm un e  dys r eg ulato ry defe c t. C ONC LU SI ONS  A N DSIGNI FIC ANCE 1.  In now 2sev er e autoinflam m at ory syndro mes , cryopyrinass ociate dper i odicsyn drome s, CAP S  (whic h include sF ACS, M W S and N O M ID ), a nd deficiency oft he ", "underscore_trick": " using_approved therapeutics_in the treatment of_these children_to_obtain answers_to_the underlying immune_dysregulatory defect. CONCLUSIONS_AND SIGNIFICANCE 1. In_now 2 severe_autoinflammatory_syndromes, cryopyrin associated periodic syndromes, CAPS (which includes FACS, MWS and NOMID), and deficiency_of_the"}
{"text": ", and Env products represent the main virion components, while Tat and Rev regulate intracellular transcriptional and post-transcriptional events for the controlled expression of viral genes. Of particular interest are the HIV accessory proteins Vif, Vpr, Vpu, Vpx, and Nef, which are unique to primate lentivir", "synonym_substitution": ", and Env products represent the main virion components, while Tat and Rev determine intracellular transcriptional and post - transcriptional event for the controlled expression of viral genes. Of finical interest are the HIV accessory proteins Vif, Vpr, Vpu, Vpx, and Nef, which are unique to primate lentivir", "butter_fingers": ", anf Env products represent the main viriou compoients, wgile Tat and Rev regulate intracellupae trabscriptional and post-tfanscriptponal evebts hor the controllxs expression kn vircl genes. Of partlcular intesest are the HHV aecessory proteins Vif, Vpr, Vpu, Vpx, anq Nef, wnifh are unique jo prpmwte mvnuivir", "random_deletion": ", and Env products represent the main while and Rev intracellular transcriptional and expression viral genes. Of interest are the accessory proteins Vif, Vpr, Vpu, Vpx, Nef, which are unique to primate lentivir", "change_char_case": ", and Env products represent thE main virioN compOneNts, WhIle TAt anD Rev regulate inTRaceLlular transcriptional aNd posT-tRAnscRIpTionaL events FOr THE coNtRoLleD eXPrEssioN of Viral geNes. Of partiCulAr Interest are tHE HiV accessorY prOteins Vif, Vpr, vpu, vpx, and neF, whICh are UniQue to PrimatE LentivIr", "whitespace_perturbation": ", and Env products represe nt the mai n vir ion  co mp onen ts,while Tat andR ev r egulate intracellulartrans cr i ptio n al  andpost-tr a ns c r ipt io na l e ve n ts  forthe  contro lled expre ssi on  of viral ge n es . Of parti cul ar interestare  the H IV  ac c essor y p rotei ns Vif ,  Vpr,Vpu, Vpx,  a n d Nef, which a r e  u niqu e to primate lent i vi r ", "underscore_trick": ", and_Env products_represent the main virion_components, while_Tat_and Rev_regulate_intracellular transcriptional and_post-transcriptional events for_the controlled expression of_viral genes. Of_particular_interest are the HIV accessory proteins Vif, Vpr, Vpu, Vpx, and Nef, which are_unique_to primate_lentivir"}
{"text": " is associated with increased risks of preterm birth and fetal loss. If these findings are replicated, they could affect vector control policies in other countries and help reduce the global burden of this persistent toxic substance. PCBs are resistant to chemical and biological breakdown and this contributed to their widespread commercial use in a variety of applications. Even though", "synonym_substitution": "is associated with increased risks of preterm birth and fetal personnel casualty. If these finding are replicated, they could affect vector control policy in other countries and help oneself reduce the global load of this persistent toxic substance. PCBs are repellent to chemical and biological breakdown and this contributed to their far-flung commercial use in a variety of applications. Even though", "butter_fingers": " is associated with increastd risks of pretetm birth and fstal losr. If these findings are replmcatwd, thtj could affect vector control iolicies un ouher countries anv help rcbuce fme glmual burden of tmis persistant toxic subsdavcz. PCBs are resistant to chemical and biologocwl breakdown agd tnys ckntributed to their widespread comjercial use in a varoety of applications. Even hhouhh", "random_deletion": "is associated with increased risks of preterm fetal If these are replicated, they in countries and help the global burden this persistent toxic substance. PCBs are to chemical and biological breakdown and this contributed to their widespread commercial use a variety of applications. Even though", "change_char_case": " is associated with increased Risks of preTerm bIrtH anD fEtal Loss. if these findingS Are rEplicated, they could affeCt vecToR ContROl PolicIes in otHEr COUntRiEs And HeLP rEduce The Global bUrden of thiS peRsIstent toxic sUBsTance. PCBs aRe rEsistant to chEmiCal and BiOloGIcal bReaKdown And thiS ContriButed to thEiR WidespREad commERCiAl usE in a variety of applICaTIons. Even though", "whitespace_perturbation": " is associated with increa sed risksof pr ete rmbi rthandfetal loss. If thes e findings are replica ted,th e y co u ld  affe ct vect o rc o ntr ol  p oli ci e sin ot her  countr ies and he lpre duce the glo b al  burden of  th is persisten t t oxic s ub sta n ce. P CBs  areresist a nt tochemicalan d  biolo g ical br e a kd ownand this contribu t ed to their wides preadco m me r c ial  us e in a var ie ty of applica t io n s .  Ev e n though", "underscore_trick": " is_associated with_increased risks of preterm_birth and_fetal_loss. If_these_findings are replicated,_they could affect_vector control policies in_other countries and_help_reduce the global burden of this persistent toxic substance. PCBs are resistant to chemical_and_biological breakdown_and_this_contributed to their widespread commercial_use in a variety of_applications. Even_though"}
{"text": " epithelial stem cell survival an/or proliferation. We have also identified and characterized a novel proteolytic pathway that is a dominant regulator of EpCAM function. We are in the process of submitting publications that describe our results in detail. In an effort to explore EpCAM function in other tissues, we are involved in collaborations with", "synonym_substitution": "epithelial stem cell survival an / or proliferation. We have also identified and qualify a fresh proteolytic pathway that is a dominant governor of EpCAM function. We are in the summons of submitting publications that report our results in detail. In an attempt to explore EpCAM function in early tissues, we are involved in collaborations with", "butter_fingers": " eplthelial stem cell surviyal an/or prolifetarion. Wx have zlso idevtified and characterized a ioveo prouvolytic pathway that ks a domijant regylatie of EpCAM functiok. We zve in vhe process of xubmitting publications dhxt describe our results in detail. In wn effott to explore EpSAM gtnctjon in other tissues, we are involvsd in cmllaborations with", "random_deletion": "epithelial stem cell survival an/or proliferation. We identified characterized a proteolytic pathway that EpCAM We are in process of submitting that describe our results in detail. an effort to explore EpCAM function in other tissues, we are involved in with", "change_char_case": " epithelial stem cell survivaL an/or proliFeratIon. we hAvE alsO ideNtified and charACterIzed a novel proteolytic pAthwaY tHAt is A DoMinanT regulaTOr OF epCaM FuNctIoN. we Are in The Process Of submittiNg pUbLications thaT DeScribe our rEsuLts in detail. IN an Effort To ExpLOre EpcAM FunctIon in oTHer tisSues, we are InVOlved iN CollaboRATiOns wIth", "whitespace_perturbation": " epithelial stem cell surv ival an/or  prol ife rat io n. W e ha ve also identi f iedand characterized a no vel p ro t eoly t ic  path way tha t  i s a d om in ant  r e gu lator  of  EpCAMfunction.Wear e in the pro c es s of submi tti ng publicati ons  thatde scr i be ou r r esult s in d e tail.In an eff or t  to ex p lore Ep C A Mfunc tion in other tis s ue s , we are invol ved in  c o ll a b ora tio ns with", "underscore_trick": " epithelial_stem cell_survival an/or proliferation. We_have also_identified_and characterized_a_novel proteolytic pathway_that is a_dominant regulator of EpCAM_function. We are_in_the process of submitting publications that describe our results in detail. In an effort_to_explore EpCAM_function_in_other tissues, we are involved_in collaborations with"}
{"text": " wild type MC3R. We have also successfully bred and studied novel knock-in mice expressing the human wild type MC3R(hWT/hWT) and human double-mutant MC3R(hDM/hDM). MC3R(hDM/hDM) have greater weight and fat", "synonym_substitution": "wild type MC3R. We have also successfully bred and study fresh knock - in mice expressing the human raving mad character MC3R(hWT / hWT) and human double - mutant MC3R(hDM / hDM). MC3R(hDM / hDM) have greater system of weights and fat", "butter_fingers": " wipd type MC3R. We have also successfully btee and vtudies novel ynock-in mice expressing the iumab wile type MC3R(hWT/hWT) and hjman doubpe-mutant MC3R(iDM/hDM). MC3R(hDM/hDM) have grccter scight end fat", "random_deletion": "wild type MC3R. We have also successfully studied knock-in mice the human wild MC3R(hDM/hDM). have greater weight fat", "change_char_case": " wild type MC3R. We have also succEssfully brEd and StuDieD nOvel KnocK-in mice expressINg thE human wild type MC3R(hWT/hWt) and hUmAN douBLe-MutanT MC3R(hDM/HdM). mc3r(hDm/hdM) HavE gREaTer weIghT and fat", "whitespace_perturbation": " wild type MC3R. We have a lso succes sfull y b red  a nd s tudi ed novel knock - in m ice expressing the hum an wi ld type MC 3R(hW T/hWT)a nd h uma ndo ubl e- m ut ant M C3R (hDM/hD M). MC3R(h DM/ hD M) have grea t er  weight an d f at", "underscore_trick": " wild_type MC3R._We have also successfully_bred and_studied_novel knock-in_mice_expressing the human_wild type MC3R(hWT/hWT)_and human double-mutant MC3R(hDM/hDM)._MC3R(hDM/hDM) have greater_weight_and fat"}
{"text": " for enumerating circulating tumor cells. The steps of PD assay development, clinical implementation including SOP-based specimen handling, analytical validation and transfer to a recipient clinical lab have been formalized into milestones and metrics by the SAIC-Frederick PD support program, and rigorously achieving each milestone in the process is", "synonym_substitution": "for enumerating circulating tumor cells. The steps of PD assay growth, clinical execution including SOP - based specimen treatment, analytical establishment and transfer to a recipient clinical lab have been formalized into milestone and system of measurement by the SAIC - Frederick PD support plan, and rigorously achieving each milestone in the process is", "butter_fingers": " fog enumerating circulatinn tumor cells. Thg wteps mf PD zssay dexelopment, clinical implementetiob incouding SOP-based specimdn handlijg, analyricao validatioi and transfer bo a xeripient clinicak lab have been formalizad iuto milestones and metrics by the SAYC-Fredetifk PD support krogrsi, ans rigorously achieving each milestkne in uhe process is", "random_deletion": "for enumerating circulating tumor cells. The steps assay clinical implementation SOP-based specimen handling, a clinical lab have formalized into milestones metrics by the SAIC-Frederick PD support and rigorously achieving each milestone in the process is", "change_char_case": " for enumerating circulating Tumor cells. the stEps Of Pd aSsay DeveLopment, clinicaL ImplEmentation including SOP-Based SpECimeN HaNdlinG, analytICaL VAliDaTiOn aNd TRaNsfer To a RecipieNt clinical Lab HaVe been formalIZeD into milesTonEs and metrics By tHe SAIC-frEdeRIck PD SupPort pRogram, ANd rigoRously achIeVIng eacH MilestoNE In The pRocess is", "whitespace_perturbation": " for enumerating circulati ng tumor c ells.  Th e s te ps o f PD  assay develop m ent,  clinical implementati on in cl u ding SO P-bas ed spec i me n han dl in g,an a ly tical  va lidatio n and tran sfe rto a recipie n tclinical l abhave been fo rma lizedin tom ilest one s and  metri c s by t he SAIC-F re d erickP D suppo r t  p rogr am, and rigorousl y  a c hieving each m ilesto ne in t hepro cess is", "underscore_trick": " for_enumerating circulating_tumor cells. The steps_of PD_assay_development, clinical_implementation_including SOP-based specimen_handling, analytical validation_and transfer to a_recipient clinical lab_have_been formalized into milestones and metrics by the SAIC-Frederick PD support program, and rigorously_achieving_each milestone_in_the_process is"}
{"text": " WGS library preparation and high-throughput sequencing. We employed somatic variant calling algorithms to identify de novo insertions/deletions (indel) mutations, single nucleotide variants (SNVs) and structural variants (SVs) captured within the WGS datasets for each treatment group relative to the un-treated, bulk HSP", "synonym_substitution": "WGS library preparation and high - throughput sequencing. We employed somatic random variable call algorithms to identify de novo insertions / deletion (indel) mutations, single nucleotide version (SNVs) and morphologic variants (SVs) capture within the WGS datasets for each treatment group relative to the un - cover, bulk HSP", "butter_fingers": " WGD library preparation ana high-throughpuj wequenring. We employea somatic variant calling aljorirhms uj identify de novo insertiojs/deletiins (mndel) mutations, single nmeleotjfe vcrmants (SNVs) and xtructural variants (SVs) waotbred within the WGS datasets for eacr treatkejt group relatyve uo ehe hn-treated, bulk HSP", "random_deletion": "WGS library preparation and high-throughput sequencing. We variant algorithms to de novo insertions/deletions (SNVs) structural variants (SVs) within the WGS for each treatment group relative to un-treated, bulk HSP", "change_char_case": " WGS library preparation and hIgh-throughPut seQueNciNg. we emPloyEd somatic variaNT calLing algorithms to identiFy de nOvO InseRTiOns/deLetions (INdEL) MutAtIoNs, sInGLe NucleOtiDe variaNts (SNVs) and StrUcTural variantS (sVS) captured wIthIn the WGS dataSetS for eaCh TreATment GroUp relAtive tO The un-tReated, bulK Hsp", "whitespace_perturbation": " WGS library preparation a nd high-th rough put  se qu enci ng.We employed so m atic  variant calling algor ithms  t o  ide n ti fy de  novo i n se r t ion s/ de let io n s(inde l)mutatio ns, single  nu cl eotide varia n ts  (SNVs) an d s tructural va ria nts (S Vs ) c a pture d w ithin  the W G S data sets forea c h trea t ment gr o u prela tive to the un-tr e at e d, bulk HSP", "underscore_trick": " WGS_library preparation_and high-throughput sequencing. We_employed somatic_variant_calling algorithms_to_identify de novo_insertions/deletions (indel) mutations,_single nucleotide variants (SNVs)_and structural variants_(SVs)_captured within the WGS datasets for each treatment group relative to the un-treated, bulk_HSP"}
{"text": " pathogen-like particles having a size (70 300 nm) and shape resembling spherical viruses that naturally evolved to deliver nucleic acids to the cells. They contain the pDNA in the interior surrounded by synthetic polymer bearing sugar residues on the surface recognized by the M cells and dendritic cells as pathogens. Because we can control the stability and", "synonym_substitution": "pathogen - like particles having a size (70 300 nm) and condition resemble spherical viruses that naturally develop to rescue nucleic acids to the cells. They check the pDNA in the inside surrounded by synthetic polymer bearing sugar remainder on the surface recognized by the M cell and dendritic cell as pathogens. Because we can control the stability and", "butter_fingers": " pahhogen-like particles havlng a size (70 300 nm) cbd sha'e resejbling soherical viruses that naturaplt evooved to deliver nucleiz acids tl the ceols. Uhey contain the 'SNA in bke infcrior wurrounded by xynthetic [olymer bearinc ruyar residues on the surface recognizqd by tne M cells and dgndriuic celms as pathogens. Because we can confrol tht stability and", "random_deletion": "pathogen-like particles having a size (70 300 shape spherical viruses naturally evolved to cells. contain the pDNA the interior surrounded synthetic polymer bearing sugar residues on surface recognized by the M cells and dendritic cells as pathogens. Because we control the stability and", "change_char_case": " pathogen-like particles haviNg a size (70 300 nm) aNd shaPe rEseMbLing SpheRical viruses thAT natUrally evolved to deliver NucleIc ACids TO tHe celLs. They cONtAIN thE pdNa in ThE InTerioR suRroundeD by synthetIc pOlYmer bearing sUGaR residues oN thE surface recoGniZed by tHe m ceLLs and DenDritiC cells AS pathoGens. BecauSe WE can coNTrol the STAbIlitY and", "whitespace_perturbation": " pathogen-like particles h aving a si ze (7 0 3 00nm ) an d sh ape resembling sphe rical viruses that nat urall ye volv e dto de liver n u cl e i c a ci ds  to  t h ecells . T hey con tain the p DNA  i n the interi o rsurrounded  by  synthetic p oly mer be ar ing sugar  re sidue s on t h e surf ace recog ni z ed byt he M ce l l sanddendritic cells a s  p a thogens. Becau se weca n  c o n tro l t he stabili ty  and", "underscore_trick": " pathogen-like_particles having_a size (70 300_nm) and_shape_resembling spherical_viruses_that naturally evolved_to deliver nucleic_acids to the cells._They contain the_pDNA_in the interior surrounded by synthetic polymer bearing sugar residues on the surface recognized_by_the M_cells_and_dendritic cells as pathogens. Because_we can control the stability_and"}
{"text": "-MPL antibodies conjugated to immunotoxin. In collaboration with Dr. Zhirui Wang and Dr. Diogo Magnani, proof-of-concept experiments have been initiated in non-human primates (NHP). Construction of anti-c-MPL monomeric and dimeric single-chain variable fragment (scFv", "synonym_substitution": "-MPL antibodies conjugated to immunotoxin. In collaboration with Dr. Zhirui Wang and Dr. Diogo Magnani, proof - of - concept experiments have been initiated in non - human archpriest (NHP). structure of anti - c - MPL monomeric and dimeric single - range variable shard (scFv", "butter_fingers": "-MPL antibodies conjugated tu immunotoxin. Iu collauoratioh with Df. Zhirui Wang and Dr. Diogo Megnabi, priof-of-concept experimengs have bven initiqted un non-humai primatcf (NHL). Convvruction of antl-c-MPL monomaric and dimerhc snngle-chain variable fragment (scFv", "random_deletion": "-MPL antibodies conjugated to immunotoxin. In collaboration Zhirui and Dr. Magnani, proof-of-concept experiments primates Construction of anti-c-MPL and dimeric single-chain fragment (scFv", "change_char_case": "-MPL antibodies conjugated to ImmunotoxiN. In coLlaBorAtIon wIth DR. Zhirui Wang and dR. DioGo Magnani, proof-of-concepT expeRiMEnts HAvE been InitiatED iN NOn-hUmAn PriMaTEs (nHP). CoNstRuction Of anti-c-MPL MonOmEric and dimerIC sIngle-chain VarIable fragmenT (scfv", "whitespace_perturbation": "-MPL antibodies conjugated  to immuno toxin . I n c ol labo rati on with Dr. Zh i ruiWang and Dr. Diogo Mag nani,  p r oof- o f- conce pt expe r im e n tsha ve  be en in itiat edin non- human prim ate s(NHP). Const r uc tion of an ti- c-MPL monome ric  and d im eri c  sing le- chain  varia b le fra gment (sc Fv ", "underscore_trick": "-MPL antibodies_conjugated to_immunotoxin. In collaboration with_Dr. Zhirui_Wang_and Dr._Diogo_Magnani, proof-of-concept experiments_have been initiated_in non-human primates (NHP)._Construction of anti-c-MPL_monomeric_and dimeric single-chain variable fragment (scFv"}
{"text": "RNase H) that included a region with five single amino acid substitutions in a five?amino acid segment. Surprisingly, these mutations in RNase H did not reduce the levels of full-length double stranded cDNA. Crystallographic studies by Dr. Edward Arnold and colleagues indicated that the corresponding residues of HIV-1 RT interact", "synonym_substitution": "RNase H) that included a region with five single amino acid substitutions in a five?amino acid section. amazingly, these mutant in RNase H did not reduce the levels of broad - length double maroon cDNA. Crystallographic studies by Dr. Edward Arnold and colleague indicated that the corresponding remainder of HIV-1 RT interact", "butter_fingers": "RNade H) that included a reglon with five siutle ammno acis substigutions in a five?amino acid detment. Surprisingly, these mugations ij RNase Y div not reduce the levels of fulm-pengch double strandgd cDNA. Crysdallographic sduaizs by Dr. Edward Arnold and colleaguef indicstfd that the cotresppgdinf residues of HIV-1 RT interact", "random_deletion": "RNase H) that included a region with amino substitutions in five?amino acid segment. H not reduce the of full-length double cDNA. Crystallographic studies by Dr. Edward and colleagues indicated that the corresponding residues of HIV-1 RT interact", "change_char_case": "RNase H) that included a region With five siNgle aMinO acId SubsTituTions in a five?amINo acId segment. Surprisingly, tHese mUtATionS In rNase h did not REdUCE thE lEvEls Of FUlL-lengTh dOuble stRanded cDNA. cryStAllographic sTUdIes by Dr. EdwArd arnold and colLeaGues inDiCatED that The CorreSpondiNG residUes of HIV-1 Rt iNTeract", "whitespace_perturbation": "RNase H) that included a r egion with  five  si ngl eamin o ac id substitutio n s in  a five?amino acid seg ment.  S u rpri s in gly,these m u ta t i ons  i nRNa se Hdid n otreducethe levels  of  f ull-length d o ub le strande d c DNA. Crystal log raphic  s tud i es by  Dr . Edw ard Ar n old an d colleag ue s  indic a ted tha t th e co rresponding resid u es of HIV-1 RT in teract ", "underscore_trick": "RNase H)_that included_a region with five_single amino_acid_substitutions in_a_five?amino acid segment._Surprisingly, these mutations_in RNase H did_not reduce the_levels_of full-length double stranded cDNA. Crystallographic studies by Dr. Edward Arnold and colleagues indicated_that_the corresponding_residues_of_HIV-1 RT interact"}
{"text": " is localized to the synapse and that reduction in neurotransmitter release in nlg mutants is paralleled by reduction in the number of synaptic boutons. Further evidence that nlg regulates synaptic structure is: a)mutations in nlg and its trans-synaptic partner neurexin alter the amplitude distributions of spontaneous", "synonym_substitution": "is localized to the synapse and that reduction in neurotransmitter release in nlg mutants is twin by decrease in the number of synaptic boutons. Further evidence that nlg regulates synaptic social organization is: a)mutations in nlg and its trans - synaptic partner neurexin change the amplitude distributions of ad-lib", "butter_fingers": " is localized to the synapst and that reductnin in ieurotrznsmittef release in nlg mutants is 'araolelee by reduction in the vumber of synaptix bontons. Further evmsence tmct nlf regbletes synaptic sjructure is: d)mutations in tle cnd its trans-synaptic partner neurexyn altet hhe amplitude qistgifutikns of spontaneous", "random_deletion": "is localized to the synapse and that neurotransmitter in nlg is paralleled by synaptic Further evidence that regulates synaptic structure a)mutations in nlg and its trans-synaptic neurexin alter the amplitude distributions of spontaneous", "change_char_case": " is localized to the synapse anD that reducTion iN neUroTrAnsmItteR release in nlg mUTantS is paralleled by reductiOn in tHe NUmbeR Of SynapTic boutONs. fURthEr EvIdeNcE ThAt nlg RegUlates sYnaptic strUctUrE is: a)mutationS In Nlg and its tRanS-synaptic parTneR neureXiN alTEr the AmpLitudE distrIButionS of spontaNeOUs", "whitespace_perturbation": " is localized to the synap se and tha t red uct ion  i n ne urot ransmitter rel e asein nlg mutants is para llele db y re d uc tionin then um b e r o fsy nap ti c  b outon s.Further  evidencetha tnlg regulate s  s ynaptic st ruc ture is: a)m uta tionsin  nl g  andits  tran s-syna p tic pa rtner neu re x in alt e r the a m p li tude  distributions of sp o ntaneous", "underscore_trick": " is_localized to_the synapse and that_reduction in_neurotransmitter_release in_nlg_mutants is paralleled_by reduction in_the number of synaptic_boutons. Further evidence_that_nlg regulates synaptic structure is: a)mutations in nlg and its trans-synaptic partner neurexin alter_the_amplitude distributions_of_spontaneous"}
{"text": "% CI -6.08, -0.70, Cohen's d =.79) and less odds of LOC-eating (95% CI -3.93, -0.03, Cohen's d =.38) than FB-HE. Family-based approaches that address interpersonal and emotional underp", "synonym_substitution": "% CI -6.08, -0.70, Cohen's d = .79) and less odds of LOC - eating (95% CI -3.93, -0.03, Cohen's d = .38) than FB - HE. Family - based access that cover interpersonal and emotional underp", "butter_fingers": "% CI -6.08, -0.70, Cohen's d =.79) and less odas of LOC-eating (95% CI -3.93, -0.03, Rohen's s =.38) than WB-HE. Family-based approaches vhat addrtfs interpersonal avd emotiojal undeep", "random_deletion": "% CI -6.08, -0.70, Cohen's d =.79) odds LOC-eating (95% -3.93, -0.03, Cohen's approaches address interpersonal and underp", "change_char_case": "% CI -6.08, -0.70, Cohen's d =.79) and less odds of LOC-Eating (95% CI -3.93, -0.03, CoHen's d =.38) ThaN FB-hE. famiLy-baSed approaches tHAt adDress interpersonal and eMotioNaL UndeRP", "whitespace_perturbation": "% CI -6.08, -0.70, Cohen's  d =.79) a nd le ssodd sof L OC-e ating (95% CI- 3.93 , -0.03, Cohen's d =.3 8) th an FB-H E .Famil y-based ap p r oac he stha ta dd ressint erperso nal and em oti on al underp", "underscore_trick": "% CI_-6.08, -0.70,_Cohen's d =.79) and_less odds_of_LOC-eating (95%_CI_-3.93, -0.03, Cohen's_d =.38) than_FB-HE. Family-based approaches that_address interpersonal and_emotional_underp"}
{"text": " of a serotype, namely APMV2 (2 strains), APMV3 (2 strains), and APMV8 (2 strains). Sequences already were available for two strains of APMV6: we have analyzed 2 more in addition. Also, sequencing of APMV5 is almost complete. The purpose in analyzing", "synonym_substitution": "of a serotype, namely APMV2 (2 strains), APMV3 (2 strains), and APMV8 (2 strains). Sequences already were available for two tune of APMV6: we have analyze 2 more in addition. Also, sequencing of APMV5 is about complete. The purpose in analyzing", "butter_fingers": " of a serotype, namely APMV2 (2 strains), APMV3 (2 strains), and ALMV8 (2 strxins). Sequences already were evaioable for two strains of APOV6: we havv analyzee 2 miee in addivjon. Also, sequskcing if APMV5 is almpst complede. The purpose iv cnalyzing", "random_deletion": "of a serotype, namely APMV2 (2 strains), strains), APMV8 (2 Sequences already were APMV6: have analyzed 2 in addition. Also, of APMV5 is almost complete. The in analyzing", "change_char_case": " of a serotype, namely APMV2 (2 straIns), APMV3 (2 strAins), aNd ApMV8 (2 StRainS). SeqUences already wERe avAilable for two strains of aPMV6: wE hAVe anALyZed 2 moRe in addITiON. alsO, sEqUenCiNG oF APMV5 Is aLmost coMplete. The pUrpOsE in analyzing", "whitespace_perturbation": " of a serotype, namely APM V2 (2 stra ins),  AP MV3  ( 2 st rain s), and APMV8( 2 st rains). Sequences alre ady w er e  ava i la ble f or twos tr a i nsof  A PMV 6: we  have  an alyzed2 more inadd it ion. Also, s e qu encing ofAPM V5 is almost  co mplete .The purpo sein an alyzin g ", "underscore_trick": " of_a serotype,_namely APMV2 (2 strains),_APMV3 (2_strains),_and APMV8_(2_strains). Sequences already_were available for_two strains of APMV6:_we have analyzed_2_more in addition. Also, sequencing of APMV5 is almost complete. The purpose in analyzing"}
{"text": " and vertebrates, the same complex is found in post-mitotic neurons, where it appears to play a role in microtubule organization. Further study of this gene is likely to be relevant to the mission of NIMH since the human ortholog of another origin complex subunit, ORC3, has been implicated in determining the", "synonym_substitution": "and vertebrates, the same complex is found in post - mitotic nerve cell, where it appear to play a role in microtubule constitution. Further report of this gene is likely to be relevant to the mission of NIMH since the human ortholog of another lineage complex fractional monetary unit, ORC3, has been implicated in determining the", "butter_fingers": " anf vertebrates, the same cumplex is found in posv-mitotid neuronr, where it appears to play a rile ib microtubule organizagion. Furtjer studt of rhis gene ma likeln to gc relzvent to the misslon of NIMH since the humdn oxtholog of another origin complex sufunit, OTC3, has been implycattd yn dsnevmining the", "random_deletion": "and vertebrates, the same complex is found neurons, it appears play a role of gene is likely be relevant to mission of NIMH since the human of another origin complex subunit, ORC3, has been implicated in determining the", "change_char_case": " and vertebrates, the same compLex is found In posT-miTotIc NeurOns, wHere it appears tO Play A role in microtubule orgaNizatIoN. furtHEr Study Of this gENe IS LikElY tO be ReLEvAnt to The Mission Of NIMH sincE thE hUman ortholog OF aNother origIn cOmplex subuniT, ORc3, has beEn ImpLIcateD in DeterMining THe", "whitespace_perturbation": " and vertebrates, the same  complex i s fou ndinpo st-m itot ic neurons, wh e re i t appears to play a ro le in  m i crot u bu le or ganizat i on . Fur th er  st ud y  o f thi s g ene islikely tobere levant to th e  m ission ofNIM H since thehum an ort ho log of an oth er or igin c o mplexsubunit,OR C 3, has been im p l ic ated  in determining t h e", "underscore_trick": " and_vertebrates, the_same complex is found_in post-mitotic_neurons,_where it_appears_to play a_role in microtubule_organization. Further study of_this gene is_likely_to be relevant to the mission of NIMH since the human ortholog of another_origin_complex subunit,_ORC3,_has_been implicated in determining the"}
{"text": "The Section on Cellular Biophotonics, of the Laboratory of Molecular Physiology, NIAAA, was established in April 2003. The principle aim of this section is to use imaging techniques to study how protein complexes, with special emphasis on complexes comprised of integral membrane proteins, are formed and maintained in living cells. Membrane", "synonym_substitution": "The Section on Cellular Biophotonics, of the Laboratory of Molecular Physiology, NIAAA, was established in April 2003. The principle aim of this section is to use image technique to study how protein complexes, with special stress on complexes comprised of built-in membrane proteins, are formed and maintained in life cells. Membrane", "butter_fingers": "The Section on Cellular Biokhotonics, of the Laboratmry of Moleculxr Physiology, NIAAA, was estaulisyed ib April 2003. The principle aim of tjis sectuon ms to use imaginj techniques tk stuby how protein cpmplexes, whth special em[hxsns on complexes comprised of integraj membrsnf proteins, are forkqd ahd maintained in living cells. Membdane", "random_deletion": "The Section on Cellular Biophotonics, of the Molecular NIAAA, was in April 2003. section to use imaging to study how complexes, with special emphasis on complexes of integral membrane proteins, are formed and maintained in living cells. Membrane", "change_char_case": "The Section on Cellular BiophOtonics, of tHe LabOraTorY oF MolEculAr Physiology, NIaaA, waS established in April 2003. The PrincIpLE aim OF tHis seCtion is TO uSE ImaGiNg TecHnIQuEs to sTudY how proTein compleXes, WiTh special empHAsIs on compleXes Comprised of iNteGral meMbRanE ProteIns, Are foRmed anD MaintaIned in livInG Cells. MEMbrane", "whitespace_perturbation": "The Section on Cellular Bi ophotonics , ofthe  La bo rato ry o f Molecular Ph y siol ogy, NIAAA, was establ ished  i n  Apr i l2003.  The pr i nc i p leai mofth i ssecti onis to u se imaging  te ch niques to st u dy  how prote incomplexes, w ith  speci al  em p hasis  on  comp lexesc ompris ed of int eg r al mem b rane pr o t ei ns,are formed and ma i nt a ined in living  cells .M em b r ane ", "underscore_trick": "The Section_on Cellular_Biophotonics, of the Laboratory_of Molecular_Physiology,_NIAAA, was_established_in April 2003._The principle aim_of this section is_to use imaging_techniques_to study how protein complexes, with special emphasis on complexes comprised of integral membrane_proteins,_are formed_and_maintained_in living cells. Membrane"}
{"text": " proteins that influence the development of tissue fibrosis. They are regulated by another family of proteins called tissue inhibitors of metalloproteinases. The interplay between these proteins governs tissue fibrosis in a variety of conditions. In addition, certain cytokines are known to promote pro-fibrotic events. We have attempted to elucidate the role of the above", "synonym_substitution": "proteins that influence the development of tissue fibrosis. They are regulated by another syndicate of protein called tissue inhibitors of metalloproteinases. The interplay between these protein governs weave fibrosis in a variety of conditions. In summation, sealed cytokines are known to promote pro - fibrotic events. We have attempted to clear the role of the above", "butter_fingers": " prlteins that influence tht development of jiwsue fmbrosis. They ard regulated by another familb of prottpns called tissue inhkbitors ov metalliproueinases. The intecllay bebceen fmese 'riteins governs tissue fitrosis in a vasidtv of conditions. In addition, certain sytokinrs are known to kromoue [ro-fjbrotic events. We have attempted tk elucivate the role og the above", "random_deletion": "proteins that influence the development of tissue are by another of proteins called interplay these proteins governs fibrosis in a of conditions. In addition, certain cytokines known to promote pro-fibrotic events. We have attempted to elucidate the role of above", "change_char_case": " proteins that influence the dEvelopment Of tisSue FibRoSis. THey aRe regulated by aNOtheR family of proteins calleD tissUe INhibIToRs of mEtallopROtEINasEs. thE inTeRPlAy betWeeN these pRoteins govErnS tIssue fibrosiS In A variety of ConDitions. In addItiOn, certAiN cyTOkineS arE knowN to proMOte pro-Fibrotic eVeNTs. We haVE attempTED tO eluCidate the role of thE AbOVe", "whitespace_perturbation": " proteins that influence t he develop mentoftis su e fi bros is. They are r e gula ted by another familyof pr ot e insc al led t issue i n hi b i tor sof  me ta l lo prote ina ses. Th e interpla y b et ween these p r ot eins gover nstissue fibro sis  in ava rie t y ofcon ditio ns. In additi on, certa in cytoki n es arek n ow n to  promote pro-fibr o ti c  events. We ha ve att em p te d toelu cidate the  r ole o f  the ab o ve ", "underscore_trick": " proteins_that influence_the development of tissue_fibrosis. They_are_regulated by_another_family of proteins_called tissue inhibitors_of metalloproteinases. The interplay_between these proteins_governs_tissue fibrosis in a variety of conditions. In addition, certain cytokines are known to_promote_pro-fibrotic events._We_have_attempted to elucidate the role_of the above"}
{"text": "4 (which lack classical motifs for endocytosis) are downregulated more profoundly than wt receptors. Nef induced ubiquitination of CXCR4 through recruitment of E3 ligase, AIP4 followed by a dynamin dependent endocytosis into MVBs for proteolyis. These mechanisms were confirmed by interaction between Nef, A", "synonym_substitution": "4 (which lack classical motifs for endocytosis) are downregulated more profoundly than wt receptors. Nef induce ubiquitination of CXCR4 through recruitment of E3 ligase, AIP4 take after by a dynamin dependent endocytosis into MVBs for proteolyis. These mechanisms were confirmed by interaction between Nef, A", "butter_fingers": "4 (whlch lack classical motifr for endocytosnw) are vownreghlated mure profoundly than wt recepvors. Nef unduced ubiquitination of CXCR4 nhrough rwcrumtment of E3 ligase, AIP4 followes by c vynamin dependekt endocytovis into MVBs xof 'roteolyis. These mechanisms were consirmed ny interaction bgtweem Nef, A", "random_deletion": "4 (which lack classical motifs for endocytosis) more than wt Nef induced ubiquitination E3 AIP4 followed by dynamin dependent endocytosis MVBs for proteolyis. These mechanisms were by interaction between Nef, A", "change_char_case": "4 (which lack classical motifs fOr endocytoSis) arE doWnrEgUlatEd moRe profoundly thAN wt rEceptors. Nef induced ubiqUitinAtIOn of cxCr4 throUgh recrUItMENt oF E3 LiGasE, Aip4 fOllowEd bY a dynamIn dependenT enDoCytosis into Mvbs For proteolYis. these mechaniSms Were coNfIrmED by inTerActioN betweEN Nef, A", "whitespace_perturbation": "4 (which lack classical mo tifs for e ndocy tos is)  a re d ownr egulated morep rofo undly than wt receptor s. Ne fi nduc e dubiqu itinati o no f  CX CR 4thr ou g hrecru itm ent ofE3 ligase,  AI P4  followed by adynamin de pen dent endocyt osi s into  M VBs for p rot eolyi s. The s e mech anisms we re confir m ed by i n t er acti on between Nef, A ", "underscore_trick": "4 (which_lack classical_motifs for endocytosis) are_downregulated more_profoundly_than wt_receptors._Nef induced ubiquitination_of CXCR4 through_recruitment of E3 ligase,_AIP4 followed by_a_dynamin dependent endocytosis into MVBs for proteolyis. These mechanisms were confirmed by interaction between_Nef,_A"}
{"text": " and persistent protein-protein interactions throughout the cell. (J Biol Chem In Press, 2010) Chemokine receptors constitute a sub-class in GPCR (the G-protein coupled receptors) superfamily, which is phylogenetically conserved from yeast to primates and regulate diverse biological processes besides leukocyte chemotaxis. In previous years", "synonym_substitution": "and persistent protein - protein interactions throughout the cell. (J Biol Chem In Press, 2010) Chemokine receptors establish a bomber - class in GPCR (the G - protein coupled receptors) superfamily, which is phylogenetically conserve from yeast to primates and regulate divers biological processes besides leukocyte chemotaxis. In previous years", "butter_fingers": " anf persistent protein-prottin interactions jheoughont the dell. (J Bkol Chem In Press, 2010) Chemokine rwceptirs constitute a sub-clxss in GPBR (the G-peotemn coupled recepvkrs) supcxfamimn, whieh is phylogenetlcally consarved from yeavt tl primates and regulate diverse biojogical pgocesses besidgs lelkjcyts chemotaxis. In previous years", "random_deletion": "and persistent protein-protein interactions throughout the cell. Chem Press, 2010) receptors constitute a coupled superfamily, which is conserved from yeast primates and regulate diverse biological processes leukocyte chemotaxis. In previous years", "change_char_case": " and persistent protein-proteIn interactIons tHroUghOuT the Cell. (j Biol Chem In PreSS, 2010) CheMokine receptors constitUte a sUb-CLass IN GpCR (thE G-proteIN cOUPleD rEcEptOrS) SuPerfaMilY, which iS phylogeneTicAlLy conserved fROm Yeast to priMatEs and regulatE diVerse bIoLogICal prOceSses bEsides LEukocyTe chemotaXiS. in prevIOus yearS", "whitespace_perturbation": " and persistent protein-pr otein inte racti ons  th ro ugho ut t he cell. (J Bi o l Ch em In Press, 2010) Che mokin er ecep t or s con stitute as u b-c la ss  in  G P CR  (the  G- protein  coupled r ece pt ors) superfa m il y, which i s p hylogenetica lly  conse rv edf rom y eas t toprimat e s andregulatedi v erse b i ologica l pr oces ses besides leuko c yt e  chemotaxis. I n prev io u sy e ars ", "underscore_trick": " and_persistent protein-protein_interactions throughout the cell._(J Biol_Chem_In Press,_2010)_Chemokine receptors constitute_a sub-class in_GPCR (the G-protein coupled_receptors) superfamily, which_is_phylogenetically conserved from yeast to primates and regulate diverse biological processes besides leukocyte chemotaxis._In_previous years"}
{"text": " on the cellular mechanisms underlying synaptic plasticity, these studies will give us a better understanding of how experience during development shapes brain circuitry. This report briefly describes our findings as mentioned in our objectives. Interesting MRI findings emerged related to the identification of a new intermediate phenotype and cortical circuitry. We tested whether altered dorso-l", "synonym_substitution": "on the cellular mechanisms underlying synaptic plasticity, these studies will render us a dependable understanding of how experience during development shapes genius circuitry. This report briefly identify our finding as mentioned in our objectives. Interesting MRI findings emerged relate to the identification of a new average phenotype and cortical circuitry. We tested whether altered dorso - l", "butter_fingers": " on the cellular mechanisms underlying syncptic pnasticjty, thesd studies will give us a betver ynderwtanding of how experidnce durijg develipmeit shapes brain rjrcuitrn. Thia repmct briefly desctibes our fitdings as menthoveb in our objectives. Interesting MRI sindingx fmerged relateq to ehe jdentification of a new intermediafe phenmtype and coryical circuitry. We tested ahetjer altered dorso-l", "random_deletion": "on the cellular mechanisms underlying synaptic plasticity, will us a understanding of how circuitry. report briefly describes findings as mentioned our objectives. Interesting MRI findings emerged to the identification of a new intermediate phenotype and cortical circuitry. We tested altered dorso-l", "change_char_case": " on the cellular mechanisms unDerlying syNaptiC plAstIcIty, tHese Studies will givE Us a bEtter understanding of hoW expeRiENce dURiNg devElopmenT ShAPEs bRaIn CirCuITrY. This RepOrt brieFly describEs oUr Findings as meNTiOned in our oBjeCtives. IntereStiNg MRI fInDinGS emerGed RelatEd to thE IdentiFication oF a NEw inteRMediate PHEnOtypE and cortical circuITrY. we tested whetheR alterEd DOrSO-L", "whitespace_perturbation": " on the cellular mechanism s underlyi ng sy nap tic  p last icit y, these studi e s wi ll give us a better un derst an d ingo fhow e xperien c ed u rin gde vel op m en t sha pes  braincircuitry.  Th is  report brie f ly  describes  ou r findings a s m ention ed  in our o bje ctive s. Int e restin g MRI fin di n gs eme r ged rel a t ed  tothe identificatio n  o f  a new interme diateph e no t y peand  corticalci rcuit r y. We t e st e d whe t her altered d orso-l", "underscore_trick": " on_the cellular_mechanisms underlying synaptic plasticity,_these studies_will_give us_a_better understanding of_how experience during_development shapes brain circuitry._This report briefly_describes_our findings as mentioned in our objectives. Interesting MRI findings emerged related to the_identification_of a_new_intermediate_phenotype and cortical circuitry. We_tested whether altered dorso-l"}
{"text": " in the presence of CMCP in neither of MOLT or Daudi cells. There was only a slight reduction of cell viability, cell growth, and the amount of mtDNA at 100 microM. We subsequently asked whether CMCP blocked the replication of HBVWTCe, ETV-resistant HBV (HBVETV", "synonym_substitution": "in the presence of CMCP in neither of MOLT or Daudi cells. There was only a slender decrease of cell viability, cell increase, and the measure of mtDNA at 100 microM. We subsequently asked whether CMCP blocked the replica of HBVWTCe, ETV - repellent HBV (HBVETV", "butter_fingers": " in the presence of CMCP in neither of MOLJ ir Dauvi cella. There das only a slight reduction lf cell viability, cell growth, and the wmount od mtVNA at 100 microM. Wx subseqmzntly wskeb xhether CMCP blpcked the seplication of HCVCTCe, ETV-resistant HBV (HBVETV", "random_deletion": "in the presence of CMCP in neither or cells. There only a slight growth, the amount of at 100 microM. subsequently asked whether CMCP blocked the of HBVWTCe, ETV-resistant HBV (HBVETV", "change_char_case": " in the presence of CMCP in neitHer of MOLT oR DaudI ceLls. thEre wAs onLy a slight reducTIon oF cell viability, cell growTh, and ThE AmouNT oF mtDNa at 100 micrOm. WE SUbsEqUeNtlY aSKeD whetHer cMCP bloCked the repLicAtIon of HBVWTCe, etV-Resistant HbV (HbVETV", "whitespace_perturbation": " in the presence of CMCP i n neitherof MO LTorDa udicell s. There was o n ly a  slight reduction of c ell v ia b ilit y ,cellgrowth, an d the  a mo unt  o f  m tDNAat100 mic roM. We su bse qu ently askedw he ther CMCPblo cked the rep lic ationof  HB V WTCe,  ET V-res istant HBV (H BVETV", "underscore_trick": " in_the presence_of CMCP in neither_of MOLT_or_Daudi cells._There_was only a_slight reduction of_cell viability, cell growth,_and the amount_of_mtDNA at 100 microM. We subsequently asked whether CMCP blocked the replication of HBVWTCe,_ETV-resistant_HBV (HBVETV"}
{"text": " labyrinthine layers. EpCAM-deficient placentas also contained markedly decreased numbers of parietal trophoblast giant cells, a phenotype that has previously been associated with embryonic lethality. The findings were reported in PLoS One in 2009. Thus, although mechanistic aspects of EpCAM function remain to be elucidated, EpCAM clearly has", "synonym_substitution": "labyrinthine layers. EpCAM - deficient placentas also control markedly decrease numbers of parietal trophoblast giant cells, a phenotype that has previously been consort with embryonic lethality. The findings were report in PLoS One in 2009. therefore, although mechanistic aspects of EpCAM function remain to be elucidated, EpCAM clearly suffer", "butter_fingers": " lahyrinthine layers. EpCAM-dtficient placentas also rontainsd markealy decreased numbers of parmetao trokkoblast giant cells, x phenotyie that hqs pceviously been associated with cmbrymiic lethality. Tme findings were reported iv 'LoS One in 2009. Thus, although mechanistyc aspevtd of EpCAM funstiom remzpn to be elucidated, EpCAM clearmy has", "random_deletion": "labyrinthine layers. EpCAM-deficient placentas also contained markedly of trophoblast giant a phenotype that embryonic The findings were in PLoS One 2009. Thus, although mechanistic aspects of function remain to be elucidated, EpCAM clearly has", "change_char_case": " labyrinthine layers. EpCAM-deFicient plaCentaS alSo cOnTainEd maRkedly decreaseD NumbErs of parietal trophoblaSt giaNt CElls, A PhEnotyPe that hAS pREVioUsLy BeeN aSSoCiateD wiTh embryOnic lethalIty. thE findings werE RePorted in PLOS ONe in 2009. Thus, althOugH mechaNiStiC AspecTs oF EpCAm functIOn remaIn to be eluCiDAted, EpcaM clearLY HaS", "whitespace_perturbation": " labyrinthine layers. EpCA M-deficien t pla cen tas  a lsocont ained markedly decr eased numbers of parie tal t ro p hobl a st  gian t cells ,  a p hen ot yp e t ha t  h as pr evi ously b een associ ate dwith embryon i clethality.  Th e findings w ere  repor te d i n  PLoS  On e in2009.T hus, a lthough m ec h anisti c  aspect s of  EpC AM function remai n  t o  be elucidated , EpCA Mc le a r lyhas ", "underscore_trick": " labyrinthine_layers. EpCAM-deficient_placentas also contained markedly_decreased numbers_of_parietal trophoblast_giant_cells, a phenotype_that has previously_been associated with embryonic_lethality. The findings_were_reported in PLoS One in 2009. Thus, although mechanistic aspects of EpCAM function remain_to_be elucidated,_EpCAM_clearly_has"}
{"text": ". Next, rhesus monkeys were infected twice with HPIV3 and, 11 months following the second infection, were immunized with two doses of HPIV3/EboGP given 4 weeks apart. ELISA assay of EBOV-specific serum IgG and IgA showed that the level of EBOV-specific serum antibodies following", "synonym_substitution": ". Next, rhesus monkeys were infected twice with HPIV3 and, 11 months follow the second contagion, were immunized with two doses of HPIV3 / EboGP give 4 workweek apart. ELISA assay of EBOV - specific serum IgG and IgA showed that the horizontal surface of EBOV - specific serum antibodies trace", "butter_fingers": ". Nedt, rhesus monkeys were ikfected twice wijh HPIV3 end, 11 mohths foluowing the second infection, xere immubized with two doses ow HPIV3/EboHP given 4 wetks apart. ELISA assay of CYOV-spsgific werum IgG and LgA showed dhat the level ow ZBOV-specific serum antibodies followyng", "random_deletion": ". Next, rhesus monkeys were infected twice and, months following second infection, were HPIV3/EboGP 4 weeks apart. assay of EBOV-specific IgG and IgA showed that the of EBOV-specific serum antibodies following", "change_char_case": ". Next, rhesus monkeys were infeCted twice wIth HPiV3 aNd, 11 mOnThs fOlloWing the second iNFectIon, were immunized with twO doseS oF hPIV3/eBogP givEn 4 weeks APaRT. eLIsA AsSay Of ebOv-specIfiC serum IGG and IgA shOweD tHat the level oF eBoV-specific SerUm antibodies FolLowing", "whitespace_perturbation": ". Next, rhesus monkeys wer e infected  twic e w ith  H PIV3  and , 11 months fo l lowi ng the second infectio n, we re immu n iz ed wi th twod os e s  of  H PI V3/ Eb o GP  give n 4  weeksapart. ELI SAas say of EBOV- s pe cific seru m I gG and IgA s how ed tha tthe level  of  EBOV -speci f ic ser um antibo di e s foll o wing", "underscore_trick": ". Next,_rhesus monkeys_were infected twice with_HPIV3 and,_11_months following_the_second infection, were_immunized with two_doses of HPIV3/EboGP given_4 weeks apart._ELISA_assay of EBOV-specific serum IgG and IgA showed that the level of EBOV-specific serum_antibodies_following"}
{"text": "ated with ribonucleoprotein complexes (RNPs) consisting of Cas9 bound to single guide RNAs (sgRNAs) targeting either the cxcr4 gene or the safe harbor locus AAVS1. Experimentally manipulated cells were cloned by limiting dilution and single-cell isolates were expanded in vitro to obtain sufficient genomic DNA for", "synonym_substitution": "ated with ribonucleoprotein complexes (RNPs) consisting of Cas9 bound to single template RNAs (sgRNAs) target either the cxcr4 gene or the safe harbor locus AAVS1. Experimentally fudge cell were cloned by limiting dilution and individual - cell isolates were expanded in vitro to receive sufficient genomic DNA for", "butter_fingers": "atef with ribonucleoprotein complexes (RNPs) consisving of Cas9 bouvd to single guide RNAs (sgRNEs) tqrgetung either the cxcr4 geve or the safe haebor oocus AAVS1. Experimcutallg mannpnlated cells wete cloned by limiting diludiun and single-cell isolates were expanqed in fihro to obtain fuffpcyent genomic DNA for", "random_deletion": "ated with ribonucleoprotein complexes (RNPs) consisting of to guide RNAs targeting either the harbor AAVS1. Experimentally manipulated were cloned by dilution and single-cell isolates were expanded vitro to obtain sufficient genomic DNA for", "change_char_case": "ated with ribonucleoprotein Complexes (RnPs) coNsiStiNg Of CaS9 bouNd to single guidE rNAs (SgRNAs) targeting either tHe cxcR4 gENe or THe Safe hArbor loCUs aavS1. EXpErImeNtALlY maniPulAted celLs were clonEd bY lImiting dilutIOn And single-cEll Isolates were ExpAnded iN vItrO To obtAin SuffiCient gENomic DnA for", "whitespace_perturbation": "ated with ribonucleoprotei n complexe s (RN Ps)  co ns isti ng o f Cas9 bound t o  sin gle guide RNAs (sgRNAs ) tar ge t inge it her t he cxcr 4  g e n e o rth e s af e  h arbor  lo cus AAV S1. Experi men ta lly manipula t ed  cells wer e c loned by lim iti ng dil ut ion and s ing le-ce ll iso l ates w ere expan de d  in vi t ro to o b t ai n su fficient genomicD NA for", "underscore_trick": "ated with_ribonucleoprotein complexes_(RNPs) consisting of Cas9_bound to_single_guide RNAs_(sgRNAs)_targeting either the_cxcr4 gene or_the safe harbor locus_AAVS1. Experimentally manipulated_cells_were cloned by limiting dilution and single-cell isolates were expanded in vitro to obtain_sufficient_genomic DNA_for"}
{"text": " specifically useful for monitoring Forster?s Resonance Energy Transfer (FRET) between either dissimilar (Hetero-FRET) or similar (Homo-FRET) fluorophores. We have used this microscope to develop a new, photon efficient method for measuring FRET in living cells based on spectral imaging.", "synonym_substitution": "specifically useful for monitoring Forster?s Resonance Energy Transfer (FRET) between either dissimilar (Hetero - FRET) or similar (Homo - FRET) fluorophores. We have use this microscope to originate a new, photon efficient method for quantify FRET in living cells establish on spectral imaging.", "butter_fingers": " spfcifically useful for mokitoring Forster?s Resonence Ensrgy Travsfer (FRET) between either didsumilae (Hetero-FRET) or similaf (Homo-FREN) fluoropyorew. We have used this microagope co develop a new, photon efxicient method fur measuring FRET in living cells basqd on sleftral imaging.", "random_deletion": "specifically useful for monitoring Forster?s Resonance Energy between dissimilar (Hetero-FRET) similar (Homo-FRET) fluorophores. to a new, photon method for measuring in living cells based on spectral", "change_char_case": " specifically useful for moniToring ForsTer?s REsoNanCe enerGy TrAnsfer (FRET) betwEEn eiTher dissimilar (Hetero-FReT) or sImILar (HOMo-fRET) fLuorophOReS. wE haVe UsEd tHiS MiCroscOpe To develOp a new, photOn eFfIcient method FOr Measuring FrET In living cellS baSed on sPeCtrAL imagIng.", "whitespace_perturbation": " specifically useful for m onitoringForst er? s R es onan ce E nergy Transfer (FRE T) between either diss imila r( Hete r o- FRET)  or sim i la r (Ho mo -F RET )f lu oroph ore s. We h ave used t his  m icroscope to de velop a ne w,photon effic ien t meth od  fo r  meas uri ng FR ET inl ivingcells bas ed on spe c tral im a g in g.", "underscore_trick": " specifically_useful for_monitoring Forster?s Resonance Energy_Transfer (FRET)_between_either dissimilar_(Hetero-FRET)_or similar (Homo-FRET)_fluorophores. We have_used this microscope to_develop a new,_photon_efficient method for measuring FRET in living cells based on spectral imaging."}
{"text": " of the FGF20 gene, which modulates hippocampal biology, mRNA expression, verbal episodic memory, and morphology, was shown in T allele carriers to increase HP mRNA expression, had relatively larger HP volume, reduction in verbal episodic memory, and a sharp decline in HP volume with normal aging. From mRNA expression to brain morphology", "synonym_substitution": "of the FGF20 gene, which modulates hippocampal biology, mRNA expression, verbal episodic memory, and morphology, was testify in T allele carrier to increase HP mRNA expression, had relatively large HP volume, reduction in verbal episodic memory, and a astute descent in HP volume with normal ripening. From mRNA formula to brain morphology", "butter_fingers": " of the FGF20 gene, which moduuates hippocampco biolmgy, mRHA exprersion, verbal episodic memory, abd moephology, was shown in G allele barriers ro iicrease HP mRNA xspression, had velatnvxly larger HP vplume, reduwtion in verban dpnsodic memory, and a sharp decline in HP volimf with normal wginb. Froj mRNA expression to brain morpholkgy", "random_deletion": "of the FGF20 gene, which modulates hippocampal expression, episodic memory, morphology, was shown increase mRNA expression, had larger HP volume, in verbal episodic memory, and a decline in HP volume with normal aging. From mRNA expression to brain morphology", "change_char_case": " of the FGF20 gene, which modulateS hippocampAl bioLogY, mRnA ExprEssiOn, verbal episodIC memOry, and morphology, was shoWn in T AlLEle cARrIers tO increaSE Hp MrNA ExPrEssIoN, HaD relaTivEly largEr HP volume, RedUcTion in verbal EPiSodic memorY, anD a sharp decliNe iN HP volUmE wiTH normAl aGing. FRom mRNa ExpresSion to braIn MOrpholOGy", "whitespace_perturbation": " of the FGF20 gene, whichmodulateshippo cam pal  b iolo gy,mRNA expressio n , ve rbal episodic memory,and m or p holo g y,  wasshown i n  T a lle le  c arr ie r sto in cre ase HPmRNA expre ssi on , had relati v el y larger H P v olume, reduc tio n in v er bal episo dic  memo ry, an d  a sha rp declin ei n HP v o lume wi t h  n orma l aging. From mRN A  e x pression to br ain mo rp h ol o g y", "underscore_trick": " of_the FGF20_gene, which modulates hippocampal_biology, mRNA_expression,_verbal episodic_memory,_and morphology, was_shown in T_allele carriers to increase_HP mRNA expression,_had_relatively larger HP volume, reduction in verbal episodic memory, and a sharp decline in_HP_volume with_normal_aging._From mRNA expression to brain_morphology"}
{"text": " gene expression signatures, in combination with comparative functional genomics, constitute an attractive paradigm for defining both the function of oncogenic pathways and the clinically relevant subgroups of human cancers. Transforming growth factor-beta (TGF-beta) is known to exhibit tumor stage dependent suppressive (growth inhibition) and oncogenic (inv", "synonym_substitution": "gene expression signatures, in combination with comparative functional genomics, establish an attractive prototype for defining both the function of oncogenic pathways and the clinically relevant subgroup of human cancers. Transforming emergence gene - beta (TGF - beta) is known to expose tumor stage dependent suppressive (emergence inhibition) and oncogenic (inv", "butter_fingers": " geje expression signatures, in combination with cmmparafive funztional genomics, constitute en artracupve paradigm for defiving both the funxtioi of oncogenic pefhways and ths cliuirally relevant xubgroups mf human cancess. Txansforming growth factor-beta (TGF-betw) is knpwj to exhibit tomor xeage dependent suppressive (growth inhigition) end oncogenic (imv", "random_deletion": "gene expression signatures, in combination with comparative constitute attractive paradigm defining both the the relevant subgroups of cancers. Transforming growth (TGF-beta) is known to exhibit tumor dependent suppressive (growth inhibition) and oncogenic (inv", "change_char_case": " gene expression signatures, iN combinatiOn witH coMpaRaTive FuncTional genomics, COnstItute an attractive paradIgm foR dEFiniNG bOth thE functiON oF ONcoGeNiC paThWAyS and tHe cLinicalLy relevant SubGrOups of human cANcErs. TransfoRmiNg growth factOr-bEta (TGF-BeTa) iS Known To eXhibiT tumor STage dePendent suPpREssive (GRowth inHIBiTion) And oncogenic (inv", "whitespace_perturbation": " gene expression signature s, in comb inati onwit hcomp arat ive functional geno mics, constitute an at tract iv e  par a di gm fo r defin i ng b oth  t he  fu nc t io n ofonc ogenicpathways a ndth e clinically re levant sub gro ups of human  ca ncers.  T ran s formi nggrowt h fact o r-beta  (TGF-bet a) is kno w n to ex h i bi t tu mor stage depende n ts uppressive (gr owth i nh i bi t i on)  an d oncogeni c(inv", "underscore_trick": " gene_expression signatures,_in combination with comparative_functional genomics,_constitute_an attractive_paradigm_for defining both_the function of_oncogenic pathways and the_clinically relevant subgroups_of_human cancers. Transforming growth factor-beta (TGF-beta) is known to exhibit tumor stage dependent suppressive_(growth_inhibition) and_oncogenic_(inv"}
{"text": " tip. As ECM rigidity was increased, the traction peak did not oscillate and remained in the FA center, signifying the frictional slippage regime. We found that perturbing the gradient of paxillin phosphorylation across FA by expressing Y31/118E- or Y31/118F-paxillin", "synonym_substitution": "tip. As ECM rigidity was increased, the traction acme did not hover and remained in the FA center, signify the frictional slippage regimen. We found that perturbing the gradient of paxillin phosphorylation across FA by express Y31/118E- or Y31/118F - paxillin", "butter_fingers": " tio. As ECM rigidity was ingreased, the tracjiin pean did hot osciulate and remained in the FA cwnter, signifying the frictiunal slipiage regine. Wt found that pertndbing tmz graslent mh paxillin phoskhorylation dcross FA by efpfedsing Y31/118E- or Y31/118F-paxillin", "random_deletion": "tip. As ECM rigidity was increased, the did oscillate and in the FA regime. found that perturbing gradient of paxillin across FA by expressing Y31/118E- or", "change_char_case": " tip. As ECM rigidity was increaSed, the tracTion pEak Did NoT oscIllaTe and remained iN The Fa center, signifying the frIctioNaL SlipPAgE regiMe. We fouND tHAT peRtUrBinG tHE gRadieNt oF paxillIn phosphorYlaTiOn across FA by EXpRessing Y31/118E- oR Y31/118F-Paxillin", "whitespace_perturbation": " tip. As ECM rigidity wasincreased,  thetra cti on  pea k di d not oscillat e  and  remained in the FA ce nter,  s i gnif y in g the  fricti o na l sli pp ag e r eg i me . Wefou nd that  perturbin g t he  gradient of pa xillin pho sph orylation ac ros s FA b yexp r essin g Y 31/11 8E- or Y31/11 8F-paxill in ", "underscore_trick": " tip._As ECM_rigidity was increased, the_traction peak_did_not oscillate_and_remained in the_FA center, signifying_the frictional slippage regime._We found that_perturbing_the gradient of paxillin phosphorylation across FA by expressing Y31/118E- or Y31/118F-paxillin"}
{"text": " the field will need to re-visit the interpretations placed on crystal structures of TCR-pMHC interactions to explain the self-foreign antigen affinity connection we have uncovered. These data also have important implications for understanding the nature of T cells responding to self-antigens that promote autoimmune disease and for identifying the best subset of", "synonym_substitution": "the field will need to re - visit the interpretations rate on quartz glass structures of TCR - pMHC interactions to excuse the self - foreign antigen affinity joining we have uncovered. These data besides give birth important implications for understanding the nature of T cell responding to self - antigens that advertise autoimmune disease and for identifying the best subset of", "butter_fingers": " thf field will need to re-vlsit the interprgtqtions places on cryrtal structures of TCR-pMHC iiterqctiobs to explain the self-woreign ajtigen adfinmty connection wx have ukeoversf. Thzsx data also havg important hmplications fmr uuderstanding the nature of T cells rqspondimg to self-antigegs tnwt pdomote autoimmune disease and for jdentifjing the best subxet of", "random_deletion": "the field will need to re-visit the on structures of interactions to explain we uncovered. These data have important implications understanding the nature of T cells to self-antigens that promote autoimmune disease and for identifying the best subset of", "change_char_case": " the field will need to re-visit The interprEtatiOns PlaCeD on cRystAl structures of tcR-pMhC interactions to explaiN the sElF-ForeIGn AntigEn affinITy CONneCtIoN we HaVE uNcoveRed. these daTa also have ImpOrTant implicatIOnS for undersTanDing the naturE of t cells ReSpoNDing tO seLf-antIgens tHAt promOte autoimMuNE diseaSE and for IDEnTifyIng the best subset oF", "whitespace_perturbation": " the field will need to re -visit the  inte rpr eta ti onsplac ed on crystals truc tures of TCR-pMHC inte racti on s  toe xp lainthe sel f -f o r eig nan tig en af finit y c onnecti on we have  un co vered. These da ta also ha veimportant im pli cation sfor under sta nding  the n a ture o f T cells  r e spondi n g to se l f -a ntig ens that promotea ut o immune disease  and f or id e n tif yin g the best  s ubset of", "underscore_trick": " the_field will_need to re-visit the_interpretations placed_on_crystal structures_of_TCR-pMHC interactions to_explain the self-foreign_antigen affinity connection we_have uncovered. These_data_also have important implications for understanding the nature of T cells responding to self-antigens_that_promote autoimmune_disease_and_for identifying the best subset_of"}
{"text": "using HLA-I at the ER, GOLGI/TGN and the plasma membrane (PM) was associated with Nef. The binding of Nef was similarly avid for native HLA-I and recombinant HLA-I A2 at the PM. Nef binding to HLA-I at the PM was sensitive to", "synonym_substitution": "using HLA - I at the ER, GOLGI / TGN and the plasma membrane (PM) was associated with Nef. The binding of Nef was similarly avid for native HLA - I and recombinant HLA - I A2 at the prime minister. Nef tie to HLA - I at the PM was sensible to", "butter_fingers": "usijg HLA-I at the ER, GOLGI/TNN and the plasmc membrene (PM) sas assoziated with Nef. The binding lf Nef qas similarly avid for native HPA-I and eeconvinant HLA-M A2 at tmz PM. Hcf biudmng to HLA-I at jhe PM was sansitive to", "random_deletion": "using HLA-I at the ER, GOLGI/TGN and membrane was associated Nef. The binding for HLA-I and recombinant A2 at the Nef binding to HLA-I at the was sensitive to", "change_char_case": "using HLA-I at the ER, GOLGI/TGN aNd the plasmA membRanE (PM) WaS assOciaTed with Nef. The bINdinG of Nef was similarly avid For naTiVE HLA-i AnD recoMbinant hlA-i a2 At tHe pM. nef BiNDiNg to HlA-I At the PM Was sensitiVe tO", "whitespace_perturbation": "using HLA-I at the ER, GOL GI/TGN and  thepla sma  m embr ane(PM) was assoc i ated  with Nef. The binding  of N ef wass im ilarl y avidf or n ati ve  H LA- Ia nd  reco mbi nant HL A-I A2 atthe  P M. Nef bindi n gto HLA-I a t t he PM was se nsi tive t o", "underscore_trick": "using HLA-I_at the_ER, GOLGI/TGN and the_plasma membrane_(PM)_was associated_with_Nef. The binding_of Nef was_similarly avid for native_HLA-I and recombinant_HLA-I_A2 at the PM. Nef binding to HLA-I at the PM was sensitive to"}
{"text": " to the clinical lab pioneered a formal process that solves two of the most vexing and intransigent problems regarding laboratory studies of experimental drug action in cancer patient specimens at academic medical centers: first, because the drugs are experimental, the drug effect assays are highly specialized, and are only used during early clinical drug development,", "synonym_substitution": "to the clinical lab pioneered a formal process that solves two of the about exasperating and intransigent problems involve testing ground studies of experimental drug action in cancer affected role specimens at academic medical centers: foremost, because the drug are experimental, the drug effect assays are highly specialized, and are entirely used during early clinical drug development,", "butter_fingers": " to the clinical lab pioneeved a formal proewss thet solvss two ow the most vexing and intranditent kgoblems regarding laburatory snudies of exptrimental drug acvjon in gcncer iatieut specimens at scademic madical centers: fkrdt, because the drugs are experimentwl, the crkg effect assais art hyghlg specialized, and are only used duding eagly clinical drug development,", "random_deletion": "to the clinical lab pioneered a formal solves of the vexing and intransigent experimental action in cancer specimens at academic centers: first, because the drugs are the drug effect assays are highly specialized, and are only used during early drug development,", "change_char_case": " to the clinical lab pioneered A formal proCess tHat SolVeS two Of thE most vexing and INtraNsigent problems regardiNg labOrATory STuDies oF experiMEnTAL drUg AcTioN iN CaNcer pAtiEnt specImens at acaDemIc Medical centeRS: fIrst, becausE thE drugs are expEriMental, ThE drUG effeCt aSsays Are higHLy specIalized, anD aRE only uSEd durinG EArLy clInical drug developMEnT,", "whitespace_perturbation": " to the clinical lab pione ered a for mal p roc ess  t hatsolv es two of them ostvexing and intransigen t pro bl e ms r e ga rding  labora t or y stu di es  of  e x pe rimen tal  drug a ction in c anc er  patient spe c im ens at aca dem ic medical c ent ers: f ir st, becau sethe d rugs a r e expe rimental,  t h e drug effecta s sa ys a re highly special i ze d , and are only  useddu r in g ear lyclinical d ru g dev e lopment , ", "underscore_trick": " to_the clinical_lab pioneered a formal_process that_solves_two of_the_most vexing and_intransigent problems regarding_laboratory studies of experimental_drug action in_cancer_patient specimens at academic medical centers: first, because the drugs are experimental, the drug_effect_assays are_highly_specialized,_and are only used during_early clinical drug development,"}
{"text": " broad range of LH pulsatility patterns and other features that are being investigated in the context of genetic variants, where identified, in order to increase our understanding of the ontogeny of these disorders. Our phenotyping efforts have identified that uterine anomalies and Chiari type 1 malformations may represent novel non-reproductive features", "synonym_substitution": "broad range of LH pulsatility patterns and other feature that are being investigate in the context of genetic variants, where identified, in orderliness to increase our understanding of the ontogeny of these disorder. Our phenotyping efforts have identified that uterine anomaly and Chiari type 1 malformations may represent fresh non - reproductive features", "butter_fingers": " brlad range of LH pulsatillty patterns and other heaturea that afe being investigated in the cintexu of genetic variangs, where pdentifiee, in irder to iidrease our unscrstaudmng of the ontoneny of theve disorders. Ogr pkenotyping efforts have identified trat utetije anomalies agd Cnyari nyke 1 malformations may represent nkvel noi-reproductive fratures", "random_deletion": "broad range of LH pulsatility patterns and that being investigated the context of order increase our understanding the ontogeny of disorders. Our phenotyping efforts have identified uterine anomalies and Chiari type 1 malformations may represent novel non-reproductive features", "change_char_case": " broad range of LH pulsatility Patterns anD otheR feAtuReS thaT are Being investigaTEd in The context of genetic varIants, WhERe idENtIfied, In order TO iNCReaSe OuR unDeRStAndinG of The ontoGeny of thesE diSoRders. Our phenOTyPing effortS haVe identified ThaT uteriNe AnoMAlies And chiarI type 1 mALformaTions may rEpREsent nOVel non-rEPRoDuctIve features", "whitespace_perturbation": " broad range of LH pulsati lity patte rns a ndoth er  fea ture s that are bei n g in vestigated in the cont ext o fg enet i cvaria nts, wh e re i den ti fi ed,  i n  o rdertoincreas e our unde rst an ding of theo nt ogeny of t hes e disorders.  Ou r phen ot ypi n g eff ort s hav e iden t ifiedthat uter in e  anoma l ies and C hi aritype 1 malformati o ns may representnovelno n -r e p rod uct ive featur es ", "underscore_trick": " broad_range of_LH pulsatility patterns and_other features_that_are being_investigated_in the context_of genetic variants,_where identified, in order_to increase our_understanding_of the ontogeny of these disorders. Our phenotyping efforts have identified that uterine anomalies_and_Chiari type_1_malformations_may represent novel non-reproductive features"}
{"text": " de-differentiating to ISCs to regenerate the epithelium under basal and pathological ISC dynamics. Using lineage tracing in vivo and in ex vivo organoids, we show that the enterochromaffin (EC) cell is the predominant EEC with this potential. These studies suggest that an ISC gene-expressing subset", "synonym_substitution": "de - differentiating to ISCs to regenerate the epithelium under basal and pathological ISC moral force. use lineage tracing in vivo and in ex vivo organoids, we picture that the enterochromaffin (EC) cellular telephone is the predominant EEC with this potential. These study suggest that an ISC gene - expressing subset", "butter_fingers": " de-fifferentiating to ISCs uo regenerate the epithenium uhder basxl and pathological ISC dynalixs. Usung lineage tracing in vivo and in ex vuvo ieganoids, wx show tmct ths entzrichromaffin (EC) cell is tve predominant EDC with this potential. These studies fuggest tjat an ISC geng-exprtssyng albwet", "random_deletion": "de-differentiating to ISCs to regenerate the epithelium and ISC dynamics. lineage tracing in organoids, show that the (EC) cell is predominant EEC with this potential. These suggest that an ISC gene-expressing subset", "change_char_case": " de-differentiating to ISCs to Regenerate The epIthEliUm UndeR basAl and pathologiCAl ISc dynamics. Using lineage tRacinG iN Vivo ANd In ex vIvo orgaNOiDS, We sHoW tHat ThE EnTerocHroMaffin (Ec) cell is the PreDoMinant EEC witH ThIs potentiaL. ThEse studies suGgeSt that An iSC GEne-exPreSsing Subset", "whitespace_perturbation": " de-differentiating to ISC s to regen erate  th e e pi thel iumunder basal an d  pat hological ISC dynamics . Usi ng line a ge  trac ing inv iv o and  i nexvi v oorgan oid s, we s how that t heen terochromaff i n(EC) cellisthe predomin ant  EEC w it h t h is po ten tial.  These studie s suggest  t h at anI SC gene - e xp ress ing subset", "underscore_trick": " de-differentiating_to ISCs_to regenerate the epithelium_under basal_and_pathological ISC_dynamics._Using lineage tracing_in vivo and_in ex vivo organoids,_we show that_the_enterochromaffin (EC) cell is the predominant EEC with this potential. These studies suggest that_an_ISC gene-expressing_subset"}
{"text": " and after synthesis and to facilitate interaction of Vif with cellular cofactors required for the degradation of A3G. White blood cells called T lymphocytes play critical roles in immune defense against viruses, bacteria, fungi, protozoa, and cancer cells. They are also involved in allergies/asthma due to the development", "synonym_substitution": "and after synthesis and to facilitate interaction of Vif with cellular cofactors required for the abasement of A3G. blank blood cells call T lymphocytes act critical roles in immune defense against virus, bacteria, fungi, protozoa, and cancer cell. They are also involved in allergy / asthma due to the development", "butter_fingers": " anf after synthesis and to facilitate intgrqction of Vir with cdllular cofactors required flr the eegradation of A3G. Whitd blood cvlls callwd T oymphocytes play cvnticam rolzs in immune defgnse against viruses, bactesix, yungi, protozoa, and cancer cells. They are alxo involved in ajlerbyes/aanhna due to the development", "random_deletion": "and after synthesis and to facilitate interaction with cofactors required the degradation of T play critical roles immune defense against bacteria, fungi, protozoa, and cancer cells. are also involved in allergies/asthma due to the development", "change_char_case": " and after synthesis and to facIlitate intEractIon Of VIf With CellUlar cofactors rEQuirEd for the degradation of A3g. WhitE bLOod cELlS callEd T lympHOcYTEs pLaY cRitIcAL rOles iN imMune defEnse againsT viRuSes, bacteria, fUNgI, protozoa, aNd cAncer cells. ThEy aRe also InVolVEd in aLleRgies/Asthma DUe to thE developmEnT", "whitespace_perturbation": " and after synthesis and t o facilita te in ter act io n of  Vif  with cellular cofa ctors required for the  degr ad a tion of  A3G.  Whiteb lo o d  ce ll scal le d  T  lymp hoc ytes pl ay critica l r ol es in immune de fense agai nst  viruses, ba cte ria, f un gi, proto zoa , and  cance r  cells . They ar ea lso in v olved i n al lerg ies/asthma due to th e  development", "underscore_trick": " and_after synthesis_and to facilitate interaction_of Vif_with_cellular cofactors_required_for the degradation_of A3G. White_blood cells called T_lymphocytes play critical_roles_in immune defense against viruses, bacteria, fungi, protozoa, and cancer cells. They are also_involved_in allergies/asthma_due_to_the development"}
{"text": " contraction dynamics. This work is being prepared for publication Project 2: PROTEOMIC ANALYSIS OF FOCAL ADHESION MATURATION Proteomic Analysis of Myosin II-mediated Focal Adhesion Maturation Reveals a Role for -Pix in Relaxation-mediated Rac1 Activation", "synonym_substitution": "contraction dynamics. This work is being prepared for issue Project 2: PROTEOMIC psychoanalysis OF FOCAL attachment MATURATION Proteomic Analysis of Myosin II - mediated Focal Adhesion Maturation reveal a Role for -Pix in rest - mediated Rac1 Activation", "butter_fingers": " cojtraction dynamics. This dork is being ptepared hor pubmication Project 2: PROTEOMIC ANALYSIS OD FOCQL ADHESION MATURATION Proteomib Analysiw of Nyosin II-mxsiated Njcal Wdhevmon Maturation Teveals a Rone for -Pix in Seuaration-mediated Rac1 Activation", "random_deletion": "contraction dynamics. This work is being prepared Project PROTEOMIC ANALYSIS FOCAL ADHESION MATURATION Focal Maturation Reveals a for -Pix in Rac1 Activation", "change_char_case": " contraction dynamics. This woRk is being pReparEd fOr pUbLicaTion project 2: PROTEOMic ANAlYSIS OF FOCAL ADHESION MAtURATiOn protEOmIc AnaLysis of mYoSIN II-MeDiAteD FOCaL AdheSioN MaturaTion RevealS a ROlE for -Pix in RelAXaTion-mediatEd RAc1 Activation", "whitespace_perturbation": " contraction dynamics. Thi s work isbeing  pr epa re d fo r pu blication Proj e ct 2 : PROTEOMIC ANALYSIS O F FOC AL ADHE S IO N MAT URATION Pr o t eom ic  A nal ys i sof My osi n II-me diated Foc alAd hesion Matur a ti on Reveals  aRole for -Pi x i n Rela xa tio n -medi ate d Rac 1 Acti v ation", "underscore_trick": " contraction_dynamics. This_work is being prepared_for publication_Project_2: PROTEOMIC_ANALYSIS_OF FOCAL ADHESION_MATURATION Proteomic Analysis_of Myosin II-mediated Focal_Adhesion Maturation Reveals_a_Role for -Pix in Relaxation-mediated Rac1 Activation"}
{"text": " N-nitroso compounds, arsenic, dioxins, talc, and straight oil machining fluids in relation to diabetes would be useful. By definition, genes that confer a phenotype when their copy number is changed encode factors that are limiting for physiological processes. In search of dosage-sensitive genes that influence arousal and/or", "synonym_substitution": "N - nitroso compounds, arsenic, dioxins, talc, and straight oil machining fluid in relation back to diabetes would be useful. By definition, genes that confer a phenotype when their copy phone number is changed encode factors that are restrict for physiological processes. In search of dose - sensitive genes that charm arousal and/or", "butter_fingers": " N-nltroso compounds, arsenic, dioxins, talc, aue stramght oim machinkng fluids in relation to diebetws woyld be useful. By definktion, genvs that cinfec a phenotype whxh their copy hmmber ms changed encoce factors that are limidivg for physiological processes. In seawch of codage-sensitive denex thaf influence arousal and/or", "random_deletion": "N-nitroso compounds, arsenic, dioxins, talc, and straight fluids relation to would be useful. a when their copy is changed encode that are limiting for physiological processes. search of dosage-sensitive genes that influence arousal and/or", "change_char_case": " N-nitroso compounds, arsenic, dIoxins, talc, And stRaiGht OiL macHiniNg fluids in relaTIon tO diabetes would be useful. by defInITion, GEnEs thaT confer A PhENOtyPe WhEn tHeIR cOpy nuMbeR is chanGed encode fActOrS that are limiTInG for physioLogIcal processeS. In Search Of DosAGe-senSitIve geNes thaT InflueNce arousaL aND/or", "whitespace_perturbation": " N-nitroso compounds, arse nic, dioxi ns, t alc , a nd  str aigh t oil machinin g  flu ids in relation to dia betes  w o uldb eusefu l. By d e fi n i tio n,  g ene st ha t con fer  a phen otype when  th ei r copy numbe r  i s changedenc ode factorstha t areli mit i ng fo r p hysio logica l  proce sses. Inse a rch of dosage- s e ns itiv e genes that infl u en c e arousal and/ or", "underscore_trick": " N-nitroso_compounds, arsenic,_dioxins, talc, and straight_oil machining_fluids_in relation_to_diabetes would be_useful. By definition,_genes that confer a_phenotype when their_copy_number is changed encode factors that are limiting for physiological processes. In search of_dosage-sensitive_genes that_influence_arousal_and/or"}
{"text": " Based on our evaluation of the tool, which included individual interviews with 85 participants and three focus groups, we have finalized the workbook contents (NHGRI Protocol #12-HG-N023; PI: Laura Koehly). A manuscript describing this process has recently been published. The workbook is currently", "synonym_substitution": "Based on our evaluation of the tool, which included individual interviews with 85 participant and three stress groups, we have finalized the workbook content (NHGRI Protocol # 12 - HG - N023; PI: Laura Koehly). A manuscript report this process has recently been published. The workbook is presently", "butter_fingers": " Baded on our evaluation of the tool, which includxd indibidual ivterviews with 85 participants abd theee focus groups, we haxe finalided the wirkbiik contents (NHGRI Ixotockp #12-HG-U023; 'I: Laura Koehly). A manuscrhpt describing tfid process has recently been publishqd. The eogkbook is currgntly", "random_deletion": "Based on our evaluation of the tool, individual with 85 and three focus workbook (NHGRI Protocol #12-HG-N023; Laura Koehly). A describing this process has recently been The workbook is currently", "change_char_case": " Based on our evaluation of the Tool, which iNcludEd iNdiViDual InteRviews with 85 partICipaNts and three focus groups, We havE fINaliZEd The woRkbook cONtENTs (NhGrI proToCOl #12-hG-N023; PI: lauRa KoehlY). A manuscriPt dEsCribing this pROcEss has receNtlY been publishEd. THe workBoOk iS CurreNtlY", "whitespace_perturbation": " Based on our evaluation o f the tool , whi chinc lu dedindi vidual intervi e ws w ith 85 participants an d thr ee focu s  g roups , we ha v ef i nal iz ed  th ew or kbook  co ntents(NHGRI Pro toc ol  #12-HG-N023 ;  P I: Laura K oeh ly). A manus cri pt des cr ibi n g thi s p roces s hasr ecentl y been pu bl i shed.T he work b o ok  iscurrently", "underscore_trick": " Based_on our_evaluation of the tool,_which included_individual_interviews with_85_participants and three_focus groups, we_have finalized the workbook_contents (NHGRI Protocol_#12-HG-N023;_PI: Laura Koehly). A manuscript describing this process has recently been published. The workbook_is_currently"}
{"text": ". These findings have been described in a manuscript that has been submitted for publication. These results have recently been published in the Journal of Biological Chemistry. Studies intended to delineate the mechanism(s) by which EpCAM stabilizes selected claudins are in progress. We have also begun to propagate mouse intestinal organoids and", "synonym_substitution": ". These findings have been described in a manuscript that has been submitted for publication. These result have recently been publish in the Journal of Biological Chemistry. Studies intended to delineate the mechanism(s) by which EpCAM brace selected claudins are in progress. We have besides begun to propagate mouse intestinal organoids and", "butter_fingers": ". Thfse findings have been dtscribed in a manosxript vhat haa been sjbmitted for publication. Thede resuots have recently been publishef in the Joucnal of Biologicem Chemistry. Sfmdies mntended to dellneate the kechanism(s) by fhkck EpCAM stabilizes selected claudins are in pgogress. We havg alsp beghn to propagate mouse intestinal odganoidv and", "random_deletion": ". These findings have been described in that been submitted publication. These results the of Biological Chemistry. intended to delineate mechanism(s) by which EpCAM stabilizes selected are in progress. We have also begun to propagate mouse intestinal organoids and", "change_char_case": ". These findings have been descRibed in a maNuscrIpt ThaT hAs beEn suBmitted for publICatiOn. These results have receNtly bEeN PublIShEd in tHe JournAL oF bIolOgIcAl CHeMIsTry. StUdiEs intenDed to delinEatE tHe mechanism(s) BY wHich EpCAM sTabIlizes selectEd cLaudinS aRe iN ProgrEss. we havE also bEGun to pRopagate mOuSE intesTInal orgANOiDs anD", "whitespace_perturbation": ". These findings have been  described  in a  ma nus cr iptthat  has been subm i tted  for publication. Thes e res ul t s ha v erecen tly bee n  p u b lis he dinth e  J ourna l o f Biolo gical Chem ist ry . Studies in t en ded to del ine ate the mech ani sm(s)by  wh i ch Ep CAM  stab ilizes select ed claudi ns are in progres s .  W e ha ve also begun top ro p agate mouse in testin al or g a noi dsand", "underscore_trick": ". These_findings have_been described in a_manuscript that_has_been submitted_for_publication. These results_have recently been_published in the Journal_of Biological Chemistry._Studies_intended to delineate the mechanism(s) by which EpCAM stabilizes selected claudins are in progress._We_have also_begun_to_propagate mouse intestinal organoids and"}
{"text": " treatment since the study stopped. A less uniform response to rilonacept was observed in 2 patients, one of them was subsequently switched to the commercially available IL-6 blocking agent tocilizumab. BEHCETS DISEASE A cohort of patients with Behcets disease has been recruited by Dr. Henderson and the", "synonym_substitution": "treatment since the study stopped. A less uniform reception to rilonacept was observe in 2 patients, one of them was subsequently switch to the commercially available IL-6 obstruct agent tocilizumab. BEHCETS DISEASE A cohort of affected role with Behcets disease has been recruit by Dr. Henderson and the", "butter_fingers": " trfatment since the study rtopped. A less onuform cesponss to rilunacept was observed in 2 patmentw, one of them was subsequengly switcjed to tye cinmercially available IL-6 gpocknnj agent tocilizomab. BEHCETS DISEASE A cohmrg lf patients with Behcets disease haf been tefruited by Dr. Rendtrsjn ahd the", "random_deletion": "treatment since the study stopped. A less to was observed 2 patients, one to commercially available IL-6 agent tocilizumab. BEHCETS A cohort of patients with Behcets has been recruited by Dr. Henderson and the", "change_char_case": " treatment since the study stoPped. A less uNiforM reSpoNsE to rIlonAcept was observED in 2 pAtients, one of them was subSequeNtLY swiTChEd to tHe commeRCiALLy aVaIlAblE Il-6 BlOckinG agEnt tociLizumab. BEHcETs DiSEASE A cohorT Of Patients wiTh BEhcets diseasE haS been rEcRuiTEd by DR. HeNdersOn and tHE", "whitespace_perturbation": " treatment since the study  stopped.A les s u nif or m re spon se to rilonace p t wa s observed in 2 patien ts, o ne of t h em  wassubsequ e nt l y  sw it ch edto th e com mer ciallyavailableIL- 6blocking age n ttocilizuma b.BEHCETS DISE ASE  A coh or t o f  pati ent s wit h Behc e ts dis ease hasbe e n recr u ited by D r.  Hen derson and the", "underscore_trick": " treatment_since the_study stopped. A less_uniform response_to_rilonacept was_observed_in 2 patients,_one of them_was subsequently switched to_the commercially available_IL-6_blocking agent tocilizumab. BEHCETS DISEASE A cohort of patients with Behcets disease has been_recruited_by Dr._Henderson_and_the"}
{"text": "ranasal (IN) and intratracheal (IT) routes was immunogenic and protective against SARS challenge in African green monkeys (AGM). We also previously evaluated HPIV3 as a vector to express the single glycoprotein GP of Ebola virus (EBOV). This construct was highly immunogenic and completely protective", "synonym_substitution": "ranasal (IN) and intratracheal (IT) routes was immunogenic and protective against SARS challenge in African green monkeys (AGM). We also previously measure HPIV3 as a vector to carry the single glycoprotein GP of Ebola virus (EBOV). This construct was highly immunogenic and completely protective", "butter_fingers": "ranwsal (IN) and intratracheau (IT) routes was immunojenic ahd proteztive against SARS challenge ib Afrucan green monkeys (AGM). We also ireviouslt eveluated HPIV3 as e vector to exlvess chx single glycoptotein GP of Ebola virus (ETOX). Chis construct was highly immunogenis and cpmoletely protecjive", "random_deletion": "ranasal (IN) and intratracheal (IT) routes was protective SARS challenge African green monkeys HPIV3 a vector to the single glycoprotein of Ebola virus (EBOV). This construct highly immunogenic and completely protective", "change_char_case": "ranasal (IN) and intratracheal (iT) routes waS immuNogEniC aNd prOtecTive against SARs ChalLenge in African green monKeys (AgM). wE alsO PrEviouSly evalUAtED hPIv3 aS a VecToR To ExpreSs tHe singlE glycoprotEin gP Of Ebola virus (ebOv). This constRucT was highly imMunOgenic AnD coMPleteLy pRotecTive", "whitespace_perturbation": "ranasal (IN) and intratrac heal (IT)route s w asim muno geni c and protecti v e ag ainst SARS challenge i n Afr ic a n gr e en  monk eys (AG M ). W e a ls opre vi o us ly ev alu ated HP IV3 as a v ect or  to expresst he  single gl yco protein GP o f E bola v ir us( EBOV) . T his c onstru c t washighly im mu n ogenic and com p l et elyprotective", "underscore_trick": "ranasal (IN)_and intratracheal_(IT) routes was immunogenic_and protective_against_SARS challenge_in_African green monkeys_(AGM). We also_previously evaluated HPIV3 as_a vector to_express_the single glycoprotein GP of Ebola virus (EBOV). This construct was highly immunogenic and_completely_protective"}
{"text": ", or linked to pathogenesis or host range. Each P-MLV has an E-MLV backbone with P- or X-ERV replacements that together cover 100% of the recombinant genomes, with different substitution patterns for X- and P-ERVs. Two segments are always replaced, in envelope (Env): the", "synonym_substitution": ", or linked to pathogenesis or host range. Each P - MLV has an E - MLV spine with P- or X - ERV replacements that in concert cover 100% of the recombinant genomes, with unlike substitution patterns for X- and phosphorus - ERVs. Two segments are always substitute, in envelope (Env ): the", "butter_fingers": ", or linked to pathogenesis ur host range. Ecxh P-MLT has ah E-MLV bxckbone with P- or X-ERV replaremebts tyat together cover 100% of the recolbinant tenonws, with dihrerent substifmtion 'atterns for X- snd P-ERVs. Dwo segments ase apways replaced, in envelope (Env): the", "random_deletion": ", or linked to pathogenesis or host P-MLV an E-MLV with P- or 100% the recombinant genomes, different substitution patterns X- and P-ERVs. Two segments are replaced, in envelope (Env): the", "change_char_case": ", or linked to pathogenesis or hOst range. EaCh P-MLv haS an e-MlV baCkboNe with P- or X-ERV rEPlacEments that together coveR 100% of thE rECombINaNt genOmes, witH DiFFEreNt SuBstItUTiOn patTerNs for X- aNd P-ERVs. Two SegMeNts are always REpLaced, in envEloPe (Env): the", "whitespace_perturbation": ", or linked to pathogenesi s or hostrange . E ach  P -MLV  has  an E-MLV back b onewith P- or X-ERV repla cemen ts that to gethe r cover 10 0 %  of  t he  re co m bi nantgen omes, w ith differ ent  s ubstitutionp at terns forX-and P-ERVs.Two  segme nt s a r e alw ays  repl aced,i n enve lope (Env ): the", "underscore_trick": ", or_linked to_pathogenesis or host range._Each P-MLV_has_an E-MLV_backbone_with P- or_X-ERV replacements that_together cover 100% of_the recombinant genomes,_with_different substitution patterns for X- and P-ERVs. Two segments are always replaced, in envelope_(Env):_the"}
{"text": " A direct relationship exists between membrane-associated ARTS-1 protein levels and concordant changes in the release of soluble TNFR1. Cells over-expressing ARTS-1 demonstrated increased soluble TNFR1 release and decreased membrane-associated TNFR1, while cells expressing anti-sense ARTS-1 mRNA demonstrated decreased", "synonym_substitution": "A direct relationship exists between membrane - associated ARTS-1 protein degree and accordant changes in the release of soluble TNFR1. cell all over - expressing ARTS-1 demonstrated increased soluble TNFR1 acquittance and decreased membrane - associated TNFR1, while cell expressing anti - sense ARTS-1 mRNA demonstrated decrease", "butter_fingers": " A firect relationship exisus between membrauw-assocmated ADTS-1 protdin levels and concordant chengew in uke release of solubld TNFR1. Cepls over-wxprtssing ARTS-1 demonstrated lucreaacd sonnble TNFR1 releaxe and decseased membrana-arslciated TNFR1, while cells expressing anti-semsf ARTS-1 mRNA deionsuraeed svcveased", "random_deletion": "A direct relationship exists between membrane-associated ARTS-1 and changes in release of soluble increased TNFR1 release and membrane-associated TNFR1, while expressing anti-sense ARTS-1 mRNA demonstrated decreased", "change_char_case": " A direct relationship exists Between memBrane-AssOciAtEd ARtS-1 prOtein levels and COncoRdant changes in the releaSe of sOlUBle TnfR1. cells Over-expREsSINg ArTs-1 dEmoNsTRaTed inCreAsed solUble TNFR1 reLeaSe And decreased MEmBrane-assocIatEd TNFR1, while cEllS expreSsIng ANti-seNse aRTS-1 mrNA demONstratEd decreasEd", "whitespace_perturbation": " A direct relationship exi sts betwee n mem bra ne- as soci ated  ARTS-1 protei n  lev els and concordant cha ngesin ther el easeof solu b le T NFR 1.  C ell so ve r-exp res sing AR TS-1 demon str at ed increased so luble TNFR 1 r elease and d ecr easedme mbr a ne-as soc iated  TNFR1 ,  while  cells ex pr e ssinga nti-sen s e  A RTS- 1 mRNA demonstrat e dd ecreased", "underscore_trick": " A_direct relationship_exists between membrane-associated ARTS-1_protein levels_and_concordant changes_in_the release of_soluble TNFR1. Cells_over-expressing ARTS-1 demonstrated increased_soluble TNFR1 release_and_decreased membrane-associated TNFR1, while cells expressing anti-sense ARTS-1 mRNA demonstrated decreased"}
{"text": " activity may regulate hippocampal electrical oscillations, which arise from coordinated activity among distinct populations of neurons and are associated with cognitive functions. Using the controlled experimental system of excitatory and inhibitory Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) to manipulate CA2 neuronal activity in mice, we studied hippocampal-pref", "synonym_substitution": "activity may regulate hippocampal electrical oscillations, which rebel from coordinated natural process among distinct populations of neurons and are consort with cognitive functions. Using the manipulate experimental organization of excitatory and inhibitory Designer receptor Exclusively Activated by couturier Drugs (DREADDs) to manipulate CA2 neural activity in mice, we studied hippocampal - pref", "butter_fingers": " achivity may regulate hippucampal electrieql oscmllatiohs, which arise from coordinated actitity amont distinct populations of neurojs and aee awwociated wmfh cognlcive rmnctimis. Using the coktrolled ex[erimental sysdeo lf excitatory and inhibitory Designqr Receltlrs Exclusiveli Actpvwted by Designer Drugs (DREADDs) to manilulate BA2 neuronal activoty in mice, we studied hipoocalpal-pref", "random_deletion": "activity may regulate hippocampal electrical oscillations, which coordinated among distinct of neurons and Using controlled experimental system excitatory and inhibitory Receptors Exclusively Activated by Designer Drugs to manipulate CA2 neuronal activity in mice, we studied hippocampal-pref", "change_char_case": " activity may regulate hippocAmpal electRical OscIllAtIons, WhicH arise from coorDInatEd activity among distincT popuLaTIons OF nEuronS and are ASsOCIatEd WiTh cOgNItIve fuNctIons. UsiNg the contrOllEd Experimental SYsTem of excitAtoRy and inhibitOry designEr recEPtors excLusivEly ActIVated bY Designer drUGs (DREAdds) to manIPUlAte Ca2 neuronal activity IN mICe, we studied hipPocampAl-PReF", "whitespace_perturbation": " activity may regulate hip pocampal e lectr ica l o sc illa tion s, which arise from  coordinated activityamong  d i stin c tpopul ationso fn e uro ns  a ndar e  a ssoci ate d withcognitivefun ct ions. Usingt he  controlle d e xperimentalsys tem of  e xci t atory  an d inh ibitor y  Desig ner Recep to r s Excl u sivelyA c ti vate d by Designer Dru g s( DREADDs) to ma nipula te CA 2 neu ron al activit yin mi c e, we s t ud i e d  hi p pocampal-pref ", "underscore_trick": " activity_may regulate_hippocampal electrical oscillations, which_arise from_coordinated_activity among_distinct_populations of neurons_and are associated_with cognitive functions. Using_the controlled experimental_system_of excitatory and inhibitory Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) to manipulate_CA2_neuronal activity_in_mice,_we studied hippocampal-pref"}
{"text": "P labeling to identify SAMHD1 as a phosphoprotein, both endogenously in THP-1 cells and after exogenous expression in HeLa cells. Several amino acids in SAMHD1 were identified to be sites of phosphorylation using direct mass spectrometry Mutation of these residues to alanine, to prevent phosphorylation, or to glutamic", "synonym_substitution": "P labeling to identify SAMHD1 as a phosphoprotein, both endogenously in THP-1 cells and after exogenous expression in HeLa cell. respective amino acids in SAMHD1 were identified to be web site of phosphorylation use direct mass spectroscopy Mutation of these residues to alanine, to prevent phosphorylation, or to glutamic", "butter_fingers": "P lwbeling to identify SAMHA1 as a phosphoptorein, bmth ensogenousuy in THP-1 cells and after exlgwnous expression in HeLa ceuls. Severwl amino acivs in SAMHD1 were identiflzd to ne sicew of phosphorykation usitg direct mass soeetrometry Mutation of these residues to alamije, to prevent khospnjrylzniin, or to glutamic", "random_deletion": "P labeling to identify SAMHD1 as a endogenously THP-1 cells after exogenous expression acids SAMHD1 were identified be sites of using direct mass spectrometry Mutation of residues to alanine, to prevent phosphorylation, or to glutamic", "change_char_case": "P labeling to identify SAMHD1 aS a phosphopRoteiN, boTh eNdOgenOuslY in THP-1 cells and AFter Exogenous expression in HELa ceLlS. seveRAl Amino Acids in saMhd1 WerE iDeNtiFiED tO be siTes Of phospHorylation UsiNg Direct mass spECtRometry MutAtiOn of these resIduEs to alAnIne, TO prevEnt PhospHorylaTIon, or tO glutamic", "whitespace_perturbation": "P labeling to identify SAM HD1 as a p hosph opr ote in , bo th e ndogenously in THP- 1 cells and after exog enous  e x pres s io n inHeLa ce l ls . Sev er al  am in o  a cidsinSAMHD1were ident ifi ed  to be sites of  phosphory lat ion using di rec t mass  s pec t romet ryMutat ion of theseresiduesto alanin e , to pr e v en t ph osphorylation, or to glutamic", "underscore_trick": "P labeling_to identify_SAMHD1 as a phosphoprotein,_both endogenously_in_THP-1 cells_and_after exogenous expression_in HeLa cells._Several amino acids in_SAMHD1 were identified_to_be sites of phosphorylation using direct mass spectrometry Mutation of these residues to alanine,_to_prevent phosphorylation,_or_to_glutamic"}
{"text": " the effect of ions on the structure and dynamic properties of synthetic and biopolymers we developed a multi-scale experimental framework by combining high-resolution techniques, such as small-angle X-ray scattering (SAXS), small-angle neutron scattering (SANS), and static light scattering (SLS), with macroscopic methods", "synonym_substitution": "the effect of ions on the structure and dynamic place of synthetic and biopolymers we modernize a multi - scale experimental framework by combining high - resoluteness techniques, such as small - slant X - ray scattering (SAXS), minor - angle neutron scattering (SANS), and electrostatic light scattering (SLS), with macroscopic method acting", "butter_fingers": " thf effect of ions on the rtructure and dinqmic pcopertiss of syvthetic and biopolymers we dxveliped q multi-scale experimengal frameaork by xombmning high-resoluvjon tecmuiquea, suck es small-angle X-tay scatteritg (SAXS), small-atgue neutron scattering (SANS), and static light xcwttering (SLS), wyth kwcroabokic methods", "random_deletion": "the effect of ions on the structure properties synthetic and we developed a high-resolution such as small-angle scattering (SAXS), small-angle scattering (SANS), and static light scattering with macroscopic methods", "change_char_case": " the effect of ions on the strucTure and dynAmic pRopErtIeS of sYnthEtic and biopolyMErs wE developed a multi-scale eXperiMeNTal fRAmEwork By combiNInG HIgh-ReSoLutIoN TeChniqUes, Such as sMall-angle X-Ray ScAttering (SAXS), SMaLl-angle neuTroN scattering (SaNS), And staTiC liGHt scaTteRing (SlS), with MAcroscOpic methoDs", "whitespace_perturbation": " the effect of ions on the  structure  anddyn ami cprop erti es of syntheti c  and  biopolymers we develo ped a  m u lti- s ca le ex perimen t al f ram ew or k b yc om binin g h igh-res olution te chn iq ues, such as sm all-angleX-r ay scatterin g ( SAXS),  s mal l -angl e n eutro n scat t ering(SANS), a nd static light s c a tt erin g (SLS), with mac r os c opic methods", "underscore_trick": " the_effect of_ions on the structure_and dynamic_properties_of synthetic_and_biopolymers we developed_a multi-scale experimental_framework by combining high-resolution_techniques, such as_small-angle_X-ray scattering (SAXS), small-angle neutron scattering (SANS), and static light scattering (SLS), with macroscopic_methods"}
{"text": "fail compliance sensing regime and a frictional slippage regime as described in the clutch oscillation model (Chan and Odde, 2008). In the load and fail regime, the position of peak traction within the FA resided on average at the distal FA tip, but oscillated over time towards the FA center and back to the", "synonym_substitution": "fail compliance sensing regime and a frictional slippage regime as trace in the clutch cycle model (Chan and Odde, 2008). In the load and fail government, the status of peak traction within the FA resided on median at the distal FA point, but oscillated over time towards the FA center and back to the", "butter_fingers": "faip compliance sensing reglme and a frictional slmppage degime ar described in the clutch osrillqtion model (Chan and Odde, 2008). Kn the lowd and fqil cegime, the positmkn of pcck trzgtion xithin the FA rgsided on avarage at the dhsgap FA tip, but oscillated over time tjwards yhf FA center anq babk to fhe", "random_deletion": "fail compliance sensing regime and a frictional as in the oscillation model (Chan load fail regime, the of peak traction the FA resided on average at distal FA tip, but oscillated over time towards the FA center and back the", "change_char_case": "fail compliance sensing regiMe and a fricTionaL slIppAgE regIme aS described in thE ClutCh oscillation model (Chan And OdDe, 2008). iN the LOaD and fAil regiME, tHE PosItIoN of PeAK tRactiOn wIthin thE FA resided On aVeRage at the disTAl fA tip, but osCilLated over timE toWards tHe fA cENter aNd bAck to The", "whitespace_perturbation": "fail compliance sensing re gime and a  fric tio nal  s lipp ageregime as desc r ibed  in the clutch oscilla tionmo d el ( C ha n and  Odde,2 00 8 ) . I nth e l oa d  a nd fa ilregime,  the posit ion  o f peak tract i on  within th e F A resided on  av erageat  th e  dist alFA ti p, but oscill ated over  t i me tow a rds the F Acent er and back to th e ", "underscore_trick": "fail compliance_sensing regime_and a frictional slippage_regime as_described_in the_clutch_oscillation model (Chan_and Odde, 2008)._In the load and_fail regime, the_position_of peak traction within the FA resided on average at the distal FA tip,_but_oscillated over_time_towards_the FA center and back_to the"}
{"text": " signature showed significantly (P &lt;0.005) shortened mean survival time (16.25.3 months) compared to patients with the early TGF-beta signature (60.716.1 months). Significantly, tumors expressing the late TGF-beta-responsive genes displayed invasive phenotype and increased tumor recurrence. Also", "synonym_substitution": "signature showed significantly (P & lt;0.005) shorten base survival time (16.25.3 months) compared to affected role with the early TGF - beta signature (60.716.1 months). importantly, tumors expressing the late TGF - beta - reactive gene displayed invasive phenotype and increase tumor recurrence. Also", "butter_fingers": " sihnature showed significaktly (P &lt;0.005) shorteuwd meai survibal time (16.25.3 months) compared to patientd qith uke early TGF-beta sigvature (60.716.1 mlnths). Sitnifmcantly, tumors eelressinn the pate VGF-beta-responsiye genes divplayed invasiee pkenotype and increased tumor recurregce. Alsp", "random_deletion": "signature showed significantly (P &lt;0.005) shortened mean (16.25.3 compared to with the early tumors the late TGF-beta-responsive displayed invasive phenotype increased tumor recurrence. Also", "change_char_case": " signature showed significanTly (P &lt;0.005) shorTened MeaN suRvIval Time (16.25.3 Months) compared TO patIents with the early TGF-beTa sigNaTUre (60.716.1 mONtHs). SigNificanTLy, TUMorS eXpResSiNG tHe latE TGf-beta-reSponsive geNes DiSplayed invasIVe Phenotype aNd iNcreased tumoR reCurrenCe. alsO", "whitespace_perturbation": " signature showed signific antly (P & lt;0. 005 ) s ho rten ed m ean survival t i me ( 16.25.3 months) compar ed to  p a tien t swiththe ear l yT G F-b et asig na t ur e (60 .71 6.1 mon ths). Sign ifi ca ntly, tumors ex pressing t helate TGF-bet a-r espons iv e g e nes d isp layed  invas i ve phe notype an di ncreas e d tumor r ec urre nce. Also", "underscore_trick": " signature_showed significantly_(P &lt;0.005) shortened mean_survival time_(16.25.3_months) compared_to_patients with the_early TGF-beta signature_(60.716.1 months). Significantly, tumors_expressing the late_TGF-beta-responsive_genes displayed invasive phenotype and increased tumor recurrence. Also"}
{"text": "ending success of these proof-of-concept experiments, options will be explored to develop this concept clinically. The mechanisms underlying the profound modulation of parasite antigen-specific human T cell responses in lymphatic filariasis have been addressed by demonstrating the multiple pathways involved. In terms of APC dysfunction, human monocytes from patients with patent fil", "synonym_substitution": "ending success of these proof - of - concept experiments, choice will be explore to develop this concept clinically. The mechanisms underlying the heavy modulation of parasite antigen - specific human T cellular telephone responses in lymphatic filariasis have been addressed by demonstrating the multiple nerve pathway involved. In terms of APC dysfunction, human monocyte from patients with patent fil", "butter_fingers": "endlng success of these prouf-of-concept expgruments, optiohs will ce explored to develop this roncwpt coinically. The mechanisos underljing the profiynd modulavjon of icrasifc antngxn-specific humak T cell revponses in lym[hxtnc filariasis have been addressed by demonsyrwting the multyple [athsays involved. In terms of APC dysfhnction, human monocyyes from patients with patfnt vil", "random_deletion": "ending success of these proof-of-concept experiments, options explored develop this clinically. The mechanisms parasite human T cell in lymphatic filariasis been addressed by demonstrating the multiple involved. In terms of APC dysfunction, human monocytes from patients with patent fil", "change_char_case": "ending success of these proof-Of-concept eXperiMenTs, oPtIons Will Be explored to deVElop This concept clinically. THe mecHaNIsms UNdErlyiNg the prOFoUND moDuLaTioN oF PaRasitE anTigen-spEcific humaN T cElL responses in LYmPhatic filaRiaSis have been aDdrEssed bY dEmoNStratIng The muLtiple PAthwayS involved. in TErms of apC dysfuNCTiOn, huMan monocytes from pATiENts with patent fIl", "whitespace_perturbation": "ending success of these pr oof-of-con ceptexp eri me nts,  opt ions will be e x plor ed to develop this con ceptcl i nica l ly . The  mechan i sm s und er ly ing  t h eprofo und  modula tion of pa ras it e antigen-sp e ci fic humanT c ell response s i n lymp ha tic filar ias is ha ve bee n  addre ssed by d em o nstrat i ng them u lt iple  pathways involve d .I n terms of APC  dysfu nc t io n ,  hu man  monocytes  f rom p a tientsw it h p ate n t fil", "underscore_trick": "ending success_of these_proof-of-concept experiments, options will_be explored_to_develop this_concept_clinically. The mechanisms_underlying the profound_modulation of parasite antigen-specific_human T cell_responses_in lymphatic filariasis have been addressed by demonstrating the multiple pathways involved. In terms_of_APC dysfunction,_human_monocytes_from patients with patent fil"}
{"text": "2 by HIV-1 Vpu is mediated by cytoplasmic domain interactions. We knew that Vpu encoded by NL4-3, a widely used HIV-1 laboratory strain, antagonizes human BST-2 but not monkey or murine BST-2 leading to the impression that BST-2 antagonism by V", "synonym_substitution": "2 by HIV-1 Vpu is mediated by cytoplasmic domain interactions. We knew that Vpu encode by NL4 - 3, a wide practice HIV-1 laboratory strain, antagonize human BST-2 but not monkey or murine BST-2 leading to the mental picture that BST-2 antagonism by V", "butter_fingers": "2 by HIV-1 Vpu is mediated by gytoplasmic domanb intecactiona. We kned that Vpu encoded by NL4-3, a wmdelt usee HIV-1 laboratory straiv, antagonpzes humab BSU-2 but not monkey or murinc BST-2 peadnnj to the impresxion that TST-2 antagonism bh R", "random_deletion": "2 by HIV-1 Vpu is mediated by interactions. knew that encoded by NL4-3, strain, human BST-2 but monkey or murine leading to the impression that BST-2 by V", "change_char_case": "2 by HIV-1 Vpu is mediated by cytopLasmic domaIn intEraCtiOnS. We kNew tHat Vpu encoded bY nL4-3, a wIdely used HIV-1 laboratory StraiN, aNTagoNIzEs humAn BST-2 buT NoT MOnkEy Or MurInE bSt-2 leadIng To the imPression thAt BsT-2 Antagonism by v", "whitespace_perturbation": "2 by HIV-1 Vpu is mediated  by cytopl asmic  do mai ninte ract ions. We knewt hatVpu encoded by NL4-3,a wid el y  use d  H IV-1laborat o ry s tra in ,ant ag o ni zes h uma n BST-2  but not m onk ey  or murine B S T- 2 leadingtothe impressi onthat B ST -2a ntago nis m byV", "underscore_trick": "2 by_HIV-1 Vpu_is mediated by cytoplasmic_domain interactions._We_knew that_Vpu_encoded by NL4-3,_a widely used_HIV-1 laboratory strain, antagonizes_human BST-2 but_not_monkey or murine BST-2 leading to the impression that BST-2 antagonism by V"}
{"text": "malarial coinfections) and to mycobacterial antigens (in filarial/latent tuberculosis coinfections). Lymphatic filarial disease manifested by overt, morbid clinical pathology, characterized by swelling of the scrotal area and limb edema (hydrocele, elephantiasis, lymphedema) has been", "synonym_substitution": "malarial coinfections) and to mycobacterial antigens (in filarial / latent tuberculosis coinfections). Lymphatic filarial disease manifested by overt, morbid clinical pathology, characterized by bulge of the scrotal sphere and limb edema (hydrocele, elephantiasis, lymphedema) has been", "butter_fingers": "malwrial coinfections) and tu mycobacterial antigeis (in fjlarial/lxtent tuberculosis coinfectilnw). Lymkkatic filarial diseare manifedted by iveru, morbid clinical patholonv, chadwctexived by swelling of the scsotal area and lkmy edema (hydrocele, elephantiasis, lympredema) nad been", "random_deletion": "malarial coinfections) and to mycobacterial antigens (in coinfections). filarial disease by overt, morbid of scrotal area and edema (hydrocele, elephantiasis, has been", "change_char_case": "malarial coinfections) and to MycobacterIal anTigEns (In FilaRial/Latent tuberculOSis cOinfections). Lymphatic fiLariaL dISeasE MaNifesTed by ovERt, MORbiD cLiNicAl PAtHologY, chAracterIzed by swelLinG oF the scrotal aREa And limb edeMa (hYdrocele, elepHanTiasis, LyMphEDema) hAs bEen", "whitespace_perturbation": "malarial coinfections) and  to mycoba cteri alant ig ens(infilarial/laten t  tub erculosis coinfections ). Ly mp h atic fi laria l disea s em a nif es te d b yo ve rt, m orb id clin ical patho log y,  characteriz e dby swellin g o f the scrota l a rea an dlim b  edem a ( hydro cele,e lephan tiasis, l ym p hedema )  has be e n ", "underscore_trick": "malarial coinfections)_and to_mycobacterial antigens (in filarial/latent_tuberculosis coinfections)._Lymphatic_filarial disease_manifested_by overt, morbid_clinical pathology, characterized_by swelling of the_scrotal area and_limb_edema (hydrocele, elephantiasis, lymphedema) has been"}
{"text": " that transfection of active Rac1 (Rac1V12) induced PKC- and integrin-dependent myosin IIA phosphoryation on Ser 1916. Live cell imaging of GFP-myosin IIA revealed that Rac1 activation promotes rapid assembly, motion, and turnover of myosin IIA minifilaments, as well as", "synonym_substitution": "that transfection of active Rac1 (Rac1V12) induced PKC- and integrin - dependent myosin IIA phosphoryation on Ser 1916. Live cell imagination of GFP - myosin IIA reveal that Rac1 activation promotes rapid fabrication, movement, and turnover of myosin IIA minifilaments, as well as", "butter_fingers": " thwt transfection of activt Rac1 (Rac1V12) induceb PKC- aid intefrin-depevdent myosin IIA phosphoryatmon in See 1916. Live cell imaging ow GFP-myospn IIA recealtd that Rac1 activefion promotes vapid essembly, motion, and turnoeer of myosin HIX linifilaments, as well as", "random_deletion": "that transfection of active Rac1 (Rac1V12) induced integrin-dependent IIA phosphoryation Ser 1916. Live revealed Rac1 activation promotes assembly, motion, and of myosin IIA minifilaments, as well", "change_char_case": " that transfection of active RAc1 (Rac1V12) induCed PKc- anD inTeGrin-DepeNdent myosin IIA PHospHoryation on Ser 1916. Live cell ImagiNg OF GFP-MYoSin IIa revealED tHAT RaC1 aCtIvaTiON pRomotEs rApid assEmbly, motioN, anD tUrnover of myoSIn iIA minifilAmeNts, as well as", "whitespace_perturbation": " that transfection of acti ve Rac1 (R ac1V1 2)ind uc ed P KC-and integrin-d e pend ent myosin IIA phospho ryati on on S e r1916.  Live c e ll i mag in gofGF P -m yosin  II A revea led that R ac1  a ctivation pr o mo tes rapidass embly, motio n,and tu rn ove r  of m yos in II A mini f ilamen ts, as we ll as", "underscore_trick": " that_transfection of_active Rac1 (Rac1V12) induced_PKC- and_integrin-dependent_myosin IIA_phosphoryation_on Ser 1916._Live cell imaging_of GFP-myosin IIA revealed_that Rac1 activation_promotes_rapid assembly, motion, and turnover of myosin IIA minifilaments, as well as"}
{"text": "8(+) T cells compared to that of unexposed monocytes. Similar to results with IL-4, exposure of monocytes to live mf induced upregulation of CCL15, CCL17, CCL18, CCL22, CD274, and CD273 and downregulation of Toll-like receptor 3 (TLR3), TLR5", "synonym_substitution": "8(+) T cells compared to that of unexposed monocytes. exchangeable to result with IL-4, exposure of monocytes to live mf induce upregulation of CCL15, CCL17, CCL18, CCL22, CD274, and CD273 and downregulation of Toll - like sense organ 3 (TLR3), TLR5", "butter_fingers": "8(+) T fells compared to that on unexposed monoettes. Smmilar fo resulgs with IL-4, exposure of monocbtes to luve mf induced upregulxtion of BCL15, CCL17, CXL18, CRL22, CD274, and CD273 and downregmjatikk of Cool-like receptot 3 (TLR3), TLR5", "random_deletion": "8(+) T cells compared to that of Similar results with exposure of monocytes of CCL17, CCL18, CCL22, and CD273 and of Toll-like receptor 3 (TLR3), TLR5", "change_char_case": "8(+) T cells compared to that of uneXposed monoCytes. simIlaR tO resUlts With IL-4, exposure OF monOcytes to live mf induced uPreguLaTIon oF cCl15, CCL17, CcL18, CCL22, CD274, ANd cd273 And DoWnRegUlATiOn of TOll-Like recEptor 3 (TLR3), TLr5", "whitespace_perturbation": "8(+) T cells compared to t hat of une xpose d m ono cy tes.  Sim ilar to result s  wit h IL-4, exposure of mo nocyt es to l i ve  mf i nducedu pr e g ula ti on  of  C C L1 5, CC L17 , CCL18 , CCL22, C D27 4,  and CD273 a n ddownregula tio n of Toll-li kerecept or  3( TLR3) , T LR5", "underscore_trick": "8(+) T_cells compared_to that of unexposed_monocytes. Similar_to_results with_IL-4,_exposure of monocytes_to live mf_induced upregulation of CCL15,_CCL17, CCL18, CCL22,_CD274,_and CD273 and downregulation of Toll-like receptor 3 (TLR3), TLR5"}
{"text": " provided evidence that families are a social context for which social network based interventions may be particularly effective in motivating the dissemination of genomic risk information and engaging families in cooperative approaches to facilitate positive adaptation to disease risk. However, not much is known about other social spheres in which health information is exchanged that may be leveraged in network", "synonym_substitution": "provided evidence that families are a social context for which social network based interposition may be peculiarly effective in motivating the dissemination of genomic hazard information and engage families in cooperative approach to facilitate positive adaptation to disease hazard. However, not much is know about other social sector in which health information is exchanged that may be leverage in net", "butter_fingers": " prlvided evidence that famllies are a socico contxxt for which sucial network based intervenvionw may be particularly effecgive in mltivatint tht dissemination oh genomig risi infmcmation and engsging faminies in cooperdtkvz approaches to facilitate positive wdaptatooj to disease rysk. Njwevsg, kot much is known about other sodial spieres in which nealth information is exchwngef that may be levegaged in nejsorh", "random_deletion": "provided evidence that families are a social which network based may be particularly of risk information and families in cooperative to facilitate positive adaptation to disease However, not much is known about other social spheres in which health information exchanged that may be leveraged in network", "change_char_case": " provided evidence that familIes are a socIal coNteXt fOr WhicH socIal network baseD InteRventions may be particulArly eFfECtivE In MotivAting thE DiSSEmiNaTiOn oF gENoMic riSk iNformatIon and engaGinG fAmilies in cooPErAtive approAchEs to facilitaTe pOsitivE aDapTAtion To dIseasE risk. HOWever, nOt much is kNoWN about OTher socIAL sPherEs in which health inFOrMAtion is exchangEd that MaY Be LEVerAgeD in network", "whitespace_perturbation": " provided evidence that fa milies are  a so cia l c on text  for  which socialn etwo rk based interventions  maybe part i cu larly  effect i ve i n m ot iv ati ng th e dis sem ination  of genomi c r is k informatio n  a nd engagin g f amilies in c oop erativ eapp r oache s t o fac ilitat e  posit ive adapt at i on tod iseaser i sk . Ho wever, not much i s  k n own about othe r soci al sp h e res  in  which hea lt h inf o rmation is e x cha n ged that maybe leverage d  in  netwo rk ", "underscore_trick": " provided_evidence that_families are a social_context for_which_social network_based_interventions may be_particularly effective in_motivating the dissemination of_genomic risk information_and_engaging families in cooperative approaches to facilitate positive adaptation to disease risk. However, not_much_is known_about_other_social spheres in which health_information is exchanged that may_be leveraged_in network"}
{"text": " adhesion using human intestinal epithelial cells as a model system. We have determined that EpCAM acts in part by binding tightly to the tight junction-associated protein claudin-7. This interaction sequesters claudin-7 distinctly away from tight junctions and protects claudin-7 and associated claudin-1", "synonym_substitution": "adhesion using human intestinal epithelial cells as a model arrangement. We have determine that EpCAM acts in part by binding tightly to the compressed junction - associated protein claudin-7. This interaction seclude claudin-7 distinctly off from tight junctions and protects claudin-7 and associated claudin-1", "butter_fingers": " adjesion using human intesuinal epithelial ewlls av a mosel systdm. We have determined that E'CAM acts in part by binding tiehtly to nhe tight junrtion-associated 'dotein gjaudjk-7. Thiv interaction sgquesters cldudin-7 distinctny acay from tight junctions and protectf claudon-7 and associateq clstdin-1", "random_deletion": "adhesion using human intestinal epithelial cells as system. have determined EpCAM acts in the junction-associated protein claudin-7. interaction sequesters claudin-7 away from tight junctions and protects and associated claudin-1", "change_char_case": " adhesion using human intestiNal epithelIal ceLls As a MoDel sYsteM. We have determiNEd thAt EpCAM acts in part by binDing tIgHTly tO ThE tighT junctiON-aSSOciAtEd ProTeIN cLaudiN-7. ThIs interAction sequEstErS claudin-7 distINcTly away froM tiGht junctions And ProtecTs ClaUDin-7 anD asSociaTed claUDin-1", "whitespace_perturbation": " adhesion using human inte stinal epi theli alcel ls  asa mo del system. We have  determined that EpCAM  acts  i n  par t  b y bin ding ti g ht l y  to  t he  ti gh t  j uncti on- associa ted protei n c la udin-7. This in teractionseq uesters clau din -7 dis ti nct l y awa y f rom t ight j u nction s and pro te c ts cla u din-7 a n d  a ssoc iated claudin-1", "underscore_trick": " adhesion_using human_intestinal epithelial cells as_a model_system._We have_determined_that EpCAM acts_in part by_binding tightly to the_tight junction-associated protein_claudin-7._This interaction sequesters claudin-7 distinctly away from tight junctions and protects claudin-7 and associated_claudin-1"}
{"text": "-based interventions. To this end, we have developed an assessment tool to be used for large scale collection of social network information from participants that will identify social network typologies that might be used to tailor health promotion interventions. A description of these data was recently presented at the annual meeting of the International Network of Social Network Analysis", "synonym_substitution": "-based interventions. To this end, we have developed an assessment cock to be use for large scale collection of social net information from participants that will identify social net typology that might be used to tailor health promotion interventions. A description of these data was recently present at the annual meeting of the International Network of Social Network Analysis", "butter_fingers": "-basfd interventions. To this end, we have derwloped an asaessment tool to be used for large srale colltbtion of social netwofk informwtion frim perticipants that will idcutify docicl network typolpgies that might be used tu cailor health promotion interventionf. A desvrlption of thesg dats was gegently presented at the annual mseting mf the Internstional Network of Social Jetwlrk Analysis", "random_deletion": "-based interventions. To this end, we have assessment to be for large scale from that will identify network typologies that be used to tailor health promotion A description of these data was recently presented at the annual meeting of International Network of Social Network Analysis", "change_char_case": "-based interventions. To this eNd, we have deVelopEd aN asSeSsmeNt toOl to be used for lARge sCale collection of social NetwoRk INforMAtIon frOm partiCIpANTs tHaT wIll IdENtIfy soCiaL networK typologieS thAt Might be used tO TaIlor health ProMotion intervEntIons. A dEsCriPTion oF thEse daTa was rECently Presented At THe annuAL meetinG OF tHe InTernational NetworK Of sOcial Network AnAlysis", "whitespace_perturbation": "-based interventions. To t his end, w e hav e d eve lo pedan a ssessment tool to b e used for large scale  coll ec t iono fsocia l netwo r ki n for ma ti onfr o mparti cip ants th at will id ent if y social net w or k typologi esthat might b e u sed to  t ail o r hea lth  prom otioni nterve ntions. A  d e script i on of t h e se  dat a was recently pr e se n ted at the ann ual me et i ng o f t heInternatio na l Net w ork ofS oc i a l  Ne t work Analysis ", "underscore_trick": "-based interventions._To this_end, we have developed_an assessment_tool_to be_used_for large scale_collection of social_network information from participants_that will identify_social_network typologies that might be used to tailor health promotion interventions. A description of_these_data was_recently_presented_at the annual meeting of_the International Network of Social_Network Analysis"}
{"text": " immune surveillance may contribute to a rapid selection of tumor clones at the early stages of hepatocarcinogenesis. This aspect is under investigation. To study the in vivo effects of DLC1 deficiency, we had previously generated a Dlc1 knockout mouse strain. Homozygous mutant embryos died by 10 days of gestation with defects in several", "synonym_substitution": "immune surveillance may contribute to a rapid selection of tumor clones at the early stages of hepatocarcinogenesis. This view is under probe. To study the in vivo effects of DLC1 lack, we had previously render a Dlc1 knockout mouse strain. Homozygous mutant embryo die by 10 days of gestation with defects in several", "butter_fingers": " imlune surveillance may coktribute to a rakie selertion or tumor zlones at the early stages oh hepatocqrcinogenesis. This aspdct is unfer invewtigetion. To study tis in viyj efrccts mh DLC1 deficienci, we had preeiously generadea c Dlc1 knockout mouse strain. Homozygots mutamt embryos died fy 10 cwys kf gestation with defects in severzl", "random_deletion": "immune surveillance may contribute to a rapid tumor at the stages of hepatocarcinogenesis. To the in vivo of DLC1 deficiency, had previously generated a Dlc1 knockout strain. Homozygous mutant embryos died by 10 days of gestation with defects in", "change_char_case": " immune surveillance may contRibute to a rApid sEleCtiOn Of tuMor cLones at the earlY StagEs of hepatocarcinogenesIs. ThiS aSPect IS uNder iNvestigATiON. to sTuDy The In VIvO effeCts Of DLC1 deFiciency, we Had PrEviously geneRAtEd a Dlc1 knocKouT mouse strain. homOzygouS mUtaNT embrYos Died bY 10 days oF GestatIon with deFeCTs in seVEral", "whitespace_perturbation": " immune surveillance may c ontributeto arap idse lect ionof tumor clone s  atthe early stages of he patoc ar c inog e ne sis.This as p ec t isun de r i nv e st igati on.  To stu dy the inviv oeffects of D L C1  deficienc y,we had previ ous ly gen er ate d  a Dl c1knock out mo u se str ain. Homo zy g ous mu t ant emb r y os  die d by 10 days of g e st a tion with defe cts in  s e ve r a l", "underscore_trick": " immune_surveillance may_contribute to a rapid_selection of_tumor_clones at_the_early stages of_hepatocarcinogenesis. This aspect_is under investigation. To_study the in_vivo_effects of DLC1 deficiency, we had previously generated a Dlc1 knockout mouse strain. Homozygous_mutant_embryos died_by_10_days of gestation with defects_in several"}
{"text": " well blocked the DNA synthesis of HBVETV-RL180M/S202G/M204V, giving an IC50 value of 2,657. We then asked whether CMCP blocked the replication of HBV in hu-liver-chimeric mice. In 8 weeks following the inoculation of such mice with HBV", "synonym_substitution": "well blocked the DNA synthesis of HBVETV - RL180M / S202G / M204V, giving an IC50 value of 2,657. We then ask whether CMCP block the replication of HBV in hu - liver - chimeric mice. In 8 weeks postdate the inoculation of such mice with HBV", "butter_fingers": " wepl blocked the DNA synthtsis of HBVETV-RL180M/S202G/M204V, giting an IC50 valud of 2,657. We then asked whether RMCP blocjed the replication of HBV in hl-liver-chinerir mice. In 8 weeks followiky the lnocunetion of such mlce with HBE", "random_deletion": "well blocked the DNA synthesis of HBVETV-RL180M/S202G/M204V, IC50 of 2,657. then asked whether HBV hu-liver-chimeric mice. In weeks following the of such mice with HBV", "change_char_case": " well blocked the DNA synthesiS of HBVETV-Rl180M/S202G/M204v, giVinG aN IC50 vAlue Of 2,657. We then asked wHEtheR CMCP blocked the replicaTion oF Hbv in hU-LiVer-chImeric mICe. iN 8 WeeKs FoLloWiNG tHe inoCulAtion of Such mice wiTh HbV", "whitespace_perturbation": " well blocked the DNA synt hesis of H BVETV -RL 180 M/ S202 G/M2 04V, giving an IC50  value of 2,657. We th en as ke d  whe t he r CMC P block e dt h e r ep li cat io n  o f HBV  in  hu-liv er-chimeri c m ic e. In 8 week s  f ollowing t heinoculationofsuch m ic e w i th HB V", "underscore_trick": " well_blocked the_DNA synthesis of HBVETV-RL180M/S202G/M204V,_giving an_IC50_value of_2,657._We then asked_whether CMCP blocked_the replication of HBV_in hu-liver-chimeric mice._In_8 weeks following the inoculation of such mice with HBV"}
{"text": " inhibiting compensatory endocytosis. This application extends follow-up of old and very-old persons who have received cognitive interventions as part of ACTIVE (Advanced Cognitive Training for independent and Vital Elderly). Findings at five years indicate the effects of the intervention on cognitive abilities are durable and that these intervention effects nave transferred to", "synonym_substitution": "inhibiting compensatory endocytosis. This application extends follow - up of old and very - previous person who have received cognitive interventions as part of ACTIVE (Advanced Cognitive Training for autonomous and Vital Elderly). Findings at five years indicate the effect of the intervention on cognitive abilities are durable and that these interposition effects nave transferred to", "butter_fingers": " injibiting compensatory enaocytosis. This cpplicavion exfends foulow-up of old and very-old pecsonw who have received cognitixe intervvntions aw pact of ACTIVE (Advehced Conuitivs Trannmng for indepencent and Vhtal Elderly). Fhnaiugs at five years indicate the effeces of tne intervention jn cpdnitjne abilities are durable and thzt thest intervention effrcts nave transferred to", "random_deletion": "inhibiting compensatory endocytosis. This application extends follow-up and persons who received cognitive interventions Cognitive for independent and Elderly). Findings at years indicate the effects of the on cognitive abilities are durable and that these intervention effects nave transferred to", "change_char_case": " inhibiting compensatory endOcytosis. ThIs appLicAtiOn ExteNds fOllow-up of old anD Very-Old persons who have receiVed coGnITive INtErvenTions as PArT OF ACtIvE (advAnCEd cogniTivE TrainiNg for indepEndEnT and Vital EldERlY). Findings aT fiVe years indicAte The effEcTs oF The inTerVentiOn on coGNitive Abilities ArE DurablE And that THEsE intErvention effects nAVe TRansferred to", "whitespace_perturbation": " inhibiting compensatory e ndocytosis . Thi s a ppl ic atio n ex tends follow-u p  ofold and very-old perso ns wh oh aver ec eived  cognit i ve i nte rv en tio ns as  part  of  ACTIVE  (Advanced  Co gn itive Traini n gfor indepe nde nt and Vital  El derly) .Fin d ingsatfiveyearsi ndicat e the eff ec t s of t h e inter v e nt ionon cognitive abil i ti e s are durableand th at th e s e i nte rvention e ff ectsn ave tra n sf e r r edt o", "underscore_trick": " inhibiting_compensatory endocytosis._This application extends follow-up_of old_and_very-old persons_who_have received cognitive_interventions as part_of ACTIVE (Advanced Cognitive_Training for independent_and_Vital Elderly). Findings at five years indicate the effects of the intervention on cognitive_abilities_are durable_and_that_these intervention effects nave transferred_to"}
{"text": " with 3 different infectious agents, revealing that CD5hi T cells dominated in the memory pool over CD5 lo cells after resolution of the infectious process, that in older mice, the nave T cell pool is relatively depleted and the memory pool enriched in CD5hi T cells, and that a similar shift between in the", "synonym_substitution": "with 3 different infectious agents, revealing that CD5hi T cells dominate in the memory pond over CD5 lo cells after resolution of the infectious process, that in elder mice, the nave T cell consortium is relatively consume and the memory pool enriched in CD5hi T cells, and that a similar shift between in the", "butter_fingers": " wihh 3 different infectious agents, revealiut that CD5hi F cells aominated in the memory pool ocer CE5 lo cells after resoljtion of nhe infecriouw process, tizt in older mjge, thz iave T cell pook is relathvely depleted avd the memory pool enriched in CD5hi T cells, snf that a similwr snyft gvtceen in the", "random_deletion": "with 3 different infectious agents, revealing that cells in the pool over CD5 the process, that in mice, the nave cell pool is relatively depleted and memory pool enriched in CD5hi T cells, and that a similar shift between the", "change_char_case": " with 3 different infectious agEnts, revealIng thAt Cd5hi t cElls DomiNated in the memoRY pooL over CD5 lo cells after resOlutiOn OF the INfEctioUs proceSS, tHAT in OlDeR miCe, THe Nave T CelL pool is Relatively DepLeTed and the memORy Pool enrichEd iN CD5hi T cells, aNd tHat a siMiLar SHift bEtwEen in The", "whitespace_perturbation": " with 3 different infectio us agents,  reve ali ngth at C D5hi  T cells domin a tedin the memory pool ove r CD5  l o  cel l safter  resolu t io n ofth einf ec t io us pr oce ss, tha t in older  mi ce , the nave T ce ll pool is  re latively dep let ed and  t hem emory  po ol en riched in CD5 hi T cell s, and th a t a sim i l ar  shi ft between in the ", "underscore_trick": " with_3 different_infectious agents, revealing that_CD5hi T_cells_dominated in_the_memory pool over_CD5 lo cells_after resolution of the_infectious process, that_in_older mice, the nave T cell pool is relatively depleted and the memory pool_enriched_in CD5hi_T_cells,_and that a similar shift_between in the"}
{"text": " low-dose PCB studies continue to suggest adverse effects in animals this would strongly support the biologic plausibility that background-level PCB exposure in humans could have similar consequences. We considered the importance of assessing endocrine disruption in a large new birth cohort that has been proposed, the National Children's Study (NCS). We believe", "synonym_substitution": "low - dose PCB studies continue to indicate adverse effect in animals this would strongly support the biological plausibility that background - level PCB exposure in world could have similar consequence. We considered the importance of assessing endocrine gland disruption in a large raw parturition cohort that has been proposed, the National Children's Study (NCS). We believe", "butter_fingers": " loa-dose PCB studies continme to suggest adrwrse ehfects jn animaus this would strongly suppoct tye biilogic plausibility thxt backgrlund-leveo PCU exposure in humans could havs simnler consequences. We considared the impordavcz of assessing endocrine disruption yn a latgf new birth corort ehat has been proposed, the National Chjldren's Study (NCS). We believe", "random_deletion": "low-dose PCB studies continue to suggest adverse animals would strongly the biologic plausibility humans have similar consequences. considered the importance assessing endocrine disruption in a large birth cohort that has been proposed, the National Children's Study (NCS). We believe", "change_char_case": " low-dose PCB studies continue To suggest aDversE efFecTs In anImalS this would stroNGly sUpport the biologic plausIbiliTy THat bACkGrounD-level Pcb eXPOsuRe In HumAnS CoUld haVe sImilar cOnsequenceS. We CoNsidered the iMPoRtance of asSesSing endocrinE diSruptiOn In a LArge nEw bIrth cOhort tHAt has bEen proposEd, THe NatiONal ChilDREn'S StuDy (NCS). We believe", "whitespace_perturbation": " low-dose PCB studies cont inue to su ggest  ad ver se  eff ects  in animals th i s wo uld strongly support t he bi ol o gicp la usibi lity th a tb a ckg ro un d-l ev e lPCB e xpo sure in  humans co uld  h ave similarc on sequences.  We  consideredthe  impor ta nce of as ses singendocr i ne dis ruption i na  large new bir t h  c ohor t that has been p r op o sed, the Natio nal Ch il d re n ' s S tud y (NCS). W ebelie v e", "underscore_trick": " low-dose_PCB studies_continue to suggest adverse_effects in_animals_this would_strongly_support the biologic_plausibility that background-level_PCB exposure in humans_could have similar_consequences._We considered the importance of assessing endocrine disruption in a large new birth cohort_that_has been_proposed,_the_National Children's Study (NCS). We_believe"}
{"text": " maintains ISCs. Similar to our previous work in the duodenum of mice, we wondered if the EC cells in the distal SI that reside below +4 position were derived from reserve ISCs and were susceptible to tumorigenesis in Familial SI-NET patients. Presently, it is unknown whether there is a subset", "synonym_substitution": "maintains ISCs. Similar to our previous work in the duodenum of mouse, we wonder if the EC cells in the distal SI that reside below +4 position were derive from reserve ISCs and were susceptible to tumorigenesis in Familial SI - NET patients. soon, it is unknown whether there is a subset", "butter_fingers": " malntains ISCs. Similar to uur previous wotk in thx duodehum of mkce, we wondered if the EC ceplw in uke distal SI that reride beloa +4 posituon xere derived from reservc ISCa and xere susceptiblg to tumoriganesis in Faminixl SI-NET patients. Presently, it is unkgown whrtjer there is a subxqt", "random_deletion": "maintains ISCs. Similar to our previous work duodenum mice, we if the EC that below +4 position derived from reserve and were susceptible to tumorigenesis in SI-NET patients. Presently, it is unknown whether there is a subset", "change_char_case": " maintains ISCs. Similar to our Previous woRk in tHe dUodEnUm of Mice, We wondered if thE eC ceLls in the distal SI that reSide bElOW +4 posITiOn werE deriveD FrOM ResErVe iSCS aND wEre suScePtible tO tumorigenEsiS iN Familial SI-Net pAtients. PreSenTly, it is unknoWn wHether ThEre IS a subSet", "whitespace_perturbation": " maintains ISCs. Similar t o our prev iouswor k i ntheduod enum of mice,w e wo ndered if the EC cells  in t he dist a lSI th at resi d eb e low  + 4pos it i on  were  de rived f rom reserv e I SC s and were s u sc eptible to  tu morigenesisinFamili al  SI - NET p ati ents.  Prese n tly, i t is unkn ow n  wheth e r there i sa su bset", "underscore_trick": " maintains_ISCs. Similar_to our previous work_in the_duodenum_of mice,_we_wondered if the_EC cells in_the distal SI that_reside below +4_position_were derived from reserve ISCs and were susceptible to tumorigenesis in Familial SI-NET patients._Presently,_it is_unknown_whether_there is a subset"}
{"text": " the molecular details of two novel regulatory pathways controlling early signaling by the T cell receptor (SHP-1 phosphatase dependent negative control and MAPK mediated positive control) and a full mathematical computer description of T cell receptor (TCR) signaling that incorporates these novel regulatory pathways. Over the past several years we have focused on using the", "synonym_substitution": "the molecular details of two novel regulatory pathways operate early on signaling by the T cell sense organ (SHP-1 phosphatase dependent minus control and MAPK mediated cocksure control) and a full numerical calculator description of T cell sense organ (TCR) signaling that incorporates these fresh regulatory pathways. Over the past several years we have focused on using the", "butter_fingers": " thf molecular details of tdo novel regulajoey patiways ckntrollivg early signaling by the T rell receknor (SHP-1 phosphatase ddpendent jegative conurol and MAPK medmzted positive gontrmo) and a full msthematican computer deswrkpcion of T cell receptor (TCR) signalind that onforporates thefe npdel dvgmlatory pathways. Over the past ssveral jears we have focised on using the", "random_deletion": "the molecular details of two novel regulatory early by the cell receptor (SHP-1 MAPK positive control) and full mathematical computer of T cell receptor (TCR) signaling incorporates these novel regulatory pathways. Over the past several years we have focused using the", "change_char_case": " the molecular details of two nOvel regulaTory pAthWayS cOntrOlliNg early signaliNG by tHe T cell receptor (SHP-1 phosPhataSe DEpenDEnT negaTive conTRoL ANd MaPk mEdiAtED pOsitiVe cOntrol) aNd a full matHemAtIcal computer DEsCription of t ceLl receptor (TCr) siGnalinG tHat INcorpOraTes thEse novEL regulAtory pathWaYS. Over tHE past seVERaL yeaRs we have focused on USiNG the", "whitespace_perturbation": " the molecular details oftwo novelregul ato rypa thwa ys c ontrolling ear l y si gnaling by the T cellrecep to r  (SH P -1  phos phatase de p e nde nt  n ega ti v econtr oland MAP K mediated  po si tive control )  a nd a fullmat hematical co mpu ter de sc rip t ion o f T  cell  recep t or (TC R) signal in g  thati ncorpor a t es  the se novel regulato r yp athways. Overthe pa st se v e ral  ye ars we hav efocus e d on us i ng t h e", "underscore_trick": " the_molecular details_of two novel regulatory_pathways controlling_early_signaling by_the_T cell receptor_(SHP-1 phosphatase dependent_negative control and MAPK_mediated positive control)_and_a full mathematical computer description of T cell receptor (TCR) signaling that incorporates these_novel_regulatory pathways._Over_the_past several years we have_focused on using the"}
{"text": " served as referents. We studied serum TCDD level in relation to red blood cell count, white blood cell count, hemoglobin, hematocrit, mean corpuscular volume, platelet count, and erythrocyte sedimentation rate at each of four physical examinations over 10 years. We measured TCDD serum level in", "synonym_substitution": "served as referents. We studied serum TCDD level in relation back to crimson blood cell count, white lineage cell count, hemoglobin, hematocrit, mean corpuscular book, platelet count, and erythrocyte deposit rate at each of four physical examinations over 10 years. We measured TCDD serum horizontal surface in", "butter_fingers": " segved as referents. We stuaied serum TCDD level mn relafion to fed blood cell count, white bpoid ceol count, hemoglobin, heoatocrit, lean corpuscnlar volume, platxmet coukc, and crythxoryte sedimentatlon rate at each of four [hhsncal examinations over 10 years. We meafured TVDF serum level yn", "random_deletion": "served as referents. We studied serum TCDD relation red blood count, white blood corpuscular platelet count, and sedimentation rate at of four physical examinations over 10 We measured TCDD serum level in", "change_char_case": " served as referents. We studieD serum TCDD Level In rElaTiOn to Red bLood cell count, wHIte bLood cell count, hemoglobiN, hemaToCRit, mEAn CorpuScular vOLuME, PlaTeLeT coUnT, AnD erytHroCyte sedImentation RatE aT each of four pHYsIcal examinAtiOns over 10 years. we mEasureD TcDD SErum lEveL in", "whitespace_perturbation": " served as referents. We s tudied ser um TC DDlev el  inrela tion to red bl o od c ell count, white blood  cell  c o unt, he moglo bin, he m at o c rit ,me anco r pu scula r v olume,platelet c oun t,  and erythro c yt e sediment ati on rate at e ach  of fo ur  ph y sical  ex amina tionso ver 10  years. W em easure d  TCDD s e r um  lev el in", "underscore_trick": " served_as referents._We studied serum TCDD_level in_relation_to red_blood_cell count, white_blood cell count,_hemoglobin, hematocrit, mean corpuscular_volume, platelet count,_and_erythrocyte sedimentation rate at each of four physical examinations over 10 years. We measured_TCDD_serum level_in"}
{"text": " demonstrate that TNF bioactivity may down-regulate allergen-mediated asthmatic airway inflammation in patients with mild-to-moderate asthma. Ongoing investigations are aimed at elucidating further the molecular mechanisms that modulate TNFR1 release to the extracellular compartment. HIV/AIDS is a major cause of global morbidity and", "synonym_substitution": "demonstrate that TNF bioactivity may down - regulate allergen - mediated asthmatic airway inflammation in patient with meek - to - moderate asthma. Ongoing investigations are aimed at elucidating far the molecular mechanisms that modulate TNFR1 passing to the extracellular compartment. HIV / AIDS is a major causal agent of global morbidity and", "butter_fingers": " delonstrate that TNF bioacuivity may down-reyylate ellergeh-mediatea asthmatic airway inflammatmon un paupents with mild-to-modefate asthla. Ongoibg iivestigations arx aimed at eludldatiug further the mplecular machanisms that mudblate TNFR1 release to the extracellujar comlagtment. HIV/AIDS is s majkg gause of global morbidity and", "random_deletion": "demonstrate that TNF bioactivity may down-regulate allergen-mediated inflammation patients with asthma. Ongoing investigations the mechanisms that modulate release to the compartment. HIV/AIDS is a major cause global morbidity and", "change_char_case": " demonstrate that TNF bioactiVity may dowN-reguLatE alLeRgen-MediAted asthmatic aIRway Inflammation in patients With mIlD-To-moDErAte asThma. OngOInG INveStIgAtiOnS ArE aimeD at ElucidaTing furtheR thE mOlecular mechANiSms that modUlaTe TNFR1 releasE to The extRaCelLUlar cOmpArtmeNt. HIV/AidS is a mAjor cause Of GLobal mORbidity AND", "whitespace_perturbation": " demonstrate that TNF bioa ctivity ma y dow n-r egu la te a ller gen-mediated a s thma tic airway inflammatio n inpa t ient s  w ith m ild-to- m od e r ate  a st hma .O ng oinginv estigat ions are a ime dat elucidati n gfurther th e m olecular mec han isms t ha t m o dulat e T NFR1releas e  to th e extrace ll u lar co m partmen t .  H IV/A IDS is a major ca u se of global morb idityan d ", "underscore_trick": " demonstrate_that TNF_bioactivity may down-regulate allergen-mediated_asthmatic airway_inflammation_in patients_with_mild-to-moderate asthma. Ongoing_investigations are aimed_at elucidating further the_molecular mechanisms that_modulate_TNFR1 release to the extracellular compartment. HIV/AIDS is a major cause of global morbidity_and"}
{"text": " occupied chemoattractant receptors. Chemotaxis inhibition following short-term LPS treatment didnt result from downmodulation of signaling receptors or from inordinate increase in adhesion through integrin activation. However, chemokine stimulation of LPS treated monocytes displayed circumferential accumulation of activated integrin and F-actin polymers resulting from global recruitment of EPAC leading", "synonym_substitution": "occupied chemoattractant receptors. Chemotaxis inhibition following light - condition LPS treatment did nt result from downmodulation of signaling sense organ or from inordinate increase in attachment through integrin energizing. However, chemokine stimulation of LPS treated monocytes displayed circumferential accumulation of activate integrin and F - actin polymers resulting from ball-shaped recruitment of EPAC leading", "butter_fingers": " ocfupied chemoattractant rtceptors. Chemotaxnw inhiuition rollowine short-term LPS treatment divnt eesulu from downmodulatiun of sigjaling rwcepuors or from inorvjnate ikereass in cdiesion through lntegrin acdivation. Howevar, ckemokine stimulation of LPS treated ionocytrs displayed cirsumftregtiam accumulation of activated integrjn and H-actin polymers resulting from global recguitlent of EPAC leadijg", "random_deletion": "occupied chemoattractant receptors. Chemotaxis inhibition following short-term didnt from downmodulation signaling receptors or through activation. However, chemokine of LPS treated displayed circumferential accumulation of activated integrin F-actin polymers resulting from global recruitment of EPAC leading", "change_char_case": " occupied chemoattractant reCeptors. CheMotaxIs iNhiBiTion FollOwing short-term lpS trEatment didnt result from DownmOdULatiON oF signAling reCEpTORs oR fRoM inOrDInAte inCreAse in adHesion throUgh InTegrin activaTIoN. However, chEmoKine stimulatIon Of LPS tReAteD MonocYteS dispLayed cIRcumfeRential acCuMUlatioN Of activATEd InteGrin and F-actin polyMErS Resulting from gLobal rEcRUiTMEnt Of EpAC leading", "whitespace_perturbation": " occupied chemoattractantreceptors.  Chem ota xis  i nhib itio n following sh o rt-t erm LPS treatment didn t res ul t  fro m  d ownmo dulatio n  o f sig na li ngre c ep torsorfrom in ordinate i ncr ea se in adhesi o nthrough in teg rin activati on.  Howev er , c h emoki nestimu lation of LPS  treatedmo n ocytes display e d  c ircu mferential accumu l at i on of activate d inte gr i na n d F -ac tin polyme rs  resu l ting fr o mg l o bal recruitment o f EPAC lead i ng", "underscore_trick": " occupied_chemoattractant receptors._Chemotaxis inhibition following short-term_LPS treatment_didnt_result from_downmodulation_of signaling receptors_or from inordinate_increase in adhesion through_integrin activation. However,_chemokine_stimulation of LPS treated monocytes displayed circumferential accumulation of activated integrin and F-actin polymers_resulting_from global_recruitment_of_EPAC leading"}
{"text": " of direct drug action on the DNA methyltransferases that play major roles in controlling DNA methylation and abnormal gene silencing in cancers, and drug action on the enzyme topoisomerase I which is already a validated therapeutic target via the market approval of the camptothecins. Outsourcing the final steps of the defined,", "synonym_substitution": "of direct drug action on the DNA methyltransferases that play major function in operate DNA methylation and abnormal gene silencing in cancers, and drug action on the enzyme topoisomerase I which is already a validate therapeutic target via the marketplace blessing of the camptothecins. Outsourcing the final steps of the defined,", "butter_fingers": " of direct drug action on tme DNA methyltrauwferasxs that play magor roles in controlling DNA mwthylqtion and abnormal gend silencijg in cabcerw, and drug edtion ok the cnzymz vopoisomerase I which is dlready a valigageb therapeutic target via the market wpprovak lf the camptotrecimf. Oufsourcing the final steps of the dsfined,", "random_deletion": "of direct drug action on the DNA play roles in DNA methylation and and action on the topoisomerase I which already a validated therapeutic target via market approval of the camptothecins. Outsourcing the final steps of the defined,", "change_char_case": " of direct drug action on the DNa methyltraNsferAseS thAt Play MajoR roles in controLLing dNA methylation and abnorMal geNe SIlenCInG in caNcers, anD DrUG ActIoN oN thE eNZyMe topOisOmerase i which is alReaDy A validated thERaPeutic targEt vIa the market aPprOval of ThE caMPtothEciNs. OutSourciNG the fiNal steps oF tHE definED,", "whitespace_perturbation": " of direct drug action onthe DNA me thylt ran sfe ra sesthat  play major ro l es i n controlling DNA meth ylati on anda bn ormal  gene s i le n c ing  i ncan ce r s,  anddru g actio n on the e nzy me  topoisomera s eI which is  al ready a vali dat ed the ra peu t ic ta rge t via  the m a rket a pproval o ft he cam p totheci n s .Outs ourcing the final st e ps of the defi ned,", "underscore_trick": " of_direct drug_action on the DNA_methyltransferases that_play_major roles_in_controlling DNA methylation_and abnormal gene_silencing in cancers, and_drug action on_the_enzyme topoisomerase I which is already a validated therapeutic target via the market approval_of_the camptothecins._Outsourcing_the_final steps of the defined,"}
{"text": "2 cytoplasmic domain and partially neutralized the ability of this BST-2 variant to inhibit viral release. Interaction of Vpu and rhesus BST-2 involved a five-residue motif in the cytoplasmic domain of BST-2 previously identified as important for antagonism of monkey and great ape BST", "synonym_substitution": "2 cytoplasmic domain and partially neutralized the ability of this BST-2 variant to inhibit viral dismissal. Interaction of Vpu and rhesus BST-2 imply a five - residue motif in the cytoplasmic domain of BST-2 previously name as important for antagonism of imp and great ape BST", "butter_fingers": "2 cyhoplasmic domain and paruially neutralizeb the auility kf this CST-2 variant to inhibit viral rwleast. Interaction of Vpj and rhedus BST-2 unvooced a five-cssidue motif jk the rytoplasmic domsin of BST-2 previously idangiyied as important for antagonism of ionkey snf great ape BSJ", "random_deletion": "2 cytoplasmic domain and partially neutralized the this variant to viral release. Interaction involved five-residue motif in cytoplasmic domain of previously identified as important for antagonism monkey and great ape BST", "change_char_case": "2 cytoplasmic domain and partiAlly neutraLized The AbiLiTy of This bST-2 variant to inHIbit Viral release. InteractioN of VpU aND rheSUs bST-2 inVolved a FIvE-REsiDuE mOtiF iN ThE cytoPlaSmic domAin of BST-2 prEviOuSly identifieD As Important fOr aNtagonism of mOnkEy and gReAt aPE BST", "whitespace_perturbation": "2 cytoplasmic domain and p artially n eutra liz edth e ab ilit y of this BST- 2  var iant to inhibit viralrelea se .  Int e ra ction  of Vpu an d rhe su sBST -2 in volve d a  five-r esidue mot ifin  the cytopla s mi c domain o f B ST-2 previou sly  ident if ied as im por tantfor an t agonis m of monk ey and gr e at apeB S T", "underscore_trick": "2 cytoplasmic_domain and_partially neutralized the ability_of this_BST-2_variant to_inhibit_viral release. Interaction_of Vpu and_rhesus BST-2 involved a_five-residue motif in_the_cytoplasmic domain of BST-2 previously identified as important for antagonism of monkey and great_ape_BST"}
{"text": " We found that the fbp1 promoter was a target for Tf1 insertion and that the majority of the insertions occurred 40 nt from the position where Atf1p binds. A mutation that blocks the binding of Aft1p caused a significant reduction in Tf1 integration at the promoter of fbp1.", "synonym_substitution": "We found that the fbp1 promoter was a target for Tf1 insertion and that the majority of the interpolation occur 40 nt from the position where Atf1p binds. A mutation that obstruct the binding of Aft1p caused a meaning reduction in Tf1 integration at the promoter of fbp1.", "butter_fingers": " We found that the fbp1 promuter was a targgt for Th1 inserfion and that the majority of the indeetionw occurred 40 nt from thd positioj where Qtf1p vinds. A muvztion tmct blkgks tke binding of Afj1p caused a vignificant reguztnon in Tf1 integration at the promotew of fbl1.", "random_deletion": "We found that the fbp1 promoter was for insertion and the majority of from position where Atf1p A mutation that the binding of Aft1p caused a reduction in Tf1 integration at the promoter of fbp1.", "change_char_case": " We found that the fbp1 promoter Was a target For Tf1 InsErtIoN and That The majority of tHE insErtions occurred 40 nt from tHe posItIOn whERe atf1p bInds. A muTAtION thAt BlOckS tHE bIndinG of aft1p cauSed a signifIcaNt Reduction in TF1 InTegration aT thE promoter of fBp1.", "whitespace_perturbation": " We found that the fbp1 pr omoter was  a ta rge t f or  Tf1  ins ertion and tha t  the  majority of the inser tions  o c curr e d40 nt  from t h ep o sit io nwhe re At f1p b ind s. A mu tation tha t b lo cks the bind i ng  of Aft1pcau sed a signif ica nt red uc tio n  in T f1integ ration at the  promoter  o f  fbp1. ", "underscore_trick": " We_found that_the fbp1 promoter was_a target_for_Tf1 insertion_and_that the majority_of the insertions_occurred 40 nt from_the position where_Atf1p_binds. A mutation that blocks the binding of Aft1p caused a significant reduction in_Tf1_integration at_the_promoter_of fbp1."}
{"text": " (Gsta1, Ugt1a9) as a reflection of increasing genomic instability and production of reactive oxygen species. Moreover, a global gene expression analysis at the early stage of hepatocarcinogenesis revealed a previously unrecognized dysregulation of genes involved in innate immunity. In particular, we found an induction of several ligands", "synonym_substitution": "(Gsta1, Ugt1a9) as a reflection of increasing genomic instability and production of reactive oxygen coinage. furthermore, a ball-shaped gene expression analysis at the early stage of hepatocarcinogenesis unwrap a previously unrecognized dysregulation of genes involved in unconditioned immunity. In particular, we recover an induction of several ligand", "butter_fingers": " (Gsha1, Ugt1a9) as a reflection uf increasing ggnimic iistabiljty and oroduction of reactive oxygei spwcies. Moreover, a global gend expresspon analywis et the early stajs of heictocadginogznxsis revealed a previouslf unrecognized dhsxegulation of genes involved in innaee immumihy. In particulwr, wt fjund an induction of several ligands", "random_deletion": "(Gsta1, Ugt1a9) as a reflection of increasing and of reactive species. Moreover, a the stage of hepatocarcinogenesis a previously unrecognized of genes involved in innate immunity. particular, we found an induction of several ligands", "change_char_case": " (Gsta1, Ugt1a9) as a reflection of inCreasing geNomic InsTabIlIty aNd prOduction of reacTIve oXygen species. Moreover, a gLobal GeNE expREsSion aNalysis AT tHE EarLy StAge Of HEpAtocaRciNogenesIs revealed A prEvIously unrecoGNiZed dysreguLatIon of genes inVolVed in iNnAte IMmuniTy. IN partIcular, WE found An inductiOn OF severAL ligandS", "whitespace_perturbation": " (Gsta1, Ugt1a9) as a refl ection ofincre asi ngge nomi c in stability andp rodu ction of reactive oxyg en sp ec i es.M or eover , a glo b al g ene  e xp res si o nanaly sis  at the  early sta geof  hepatocarci n og enesis rev eal ed a previou sly  unrec og niz e d dys reg ulati on ofg enes i nvolved i ni nnatei mmunity . In  par ticular, we found an induction of s everal  l i ga n d s", "underscore_trick": " (Gsta1,_Ugt1a9) as_a reflection of increasing_genomic instability_and_production of_reactive_oxygen species. Moreover,_a global gene_expression analysis at the_early stage of_hepatocarcinogenesis_revealed a previously unrecognized dysregulation of genes involved in innate immunity. In particular, we_found_an induction_of_several_ligands"}
{"text": " assays in development at SAIC-Frederick that could be immediately transferred to accelerate reduction to SOP-driven assays that can be validated within 6-12 months and returned to the NCI for clinical implementation in the Developmental Therapeutics Clinic. It is also envisioned that as more assays are made ready for clinical use", "synonym_substitution": "assays in development at SAIC - Frederick that could be immediately transferred to accelerate reduction to SOP - drive assay that can be validated within 6 - 12 months and returned to the NCI for clinical execution in the Developmental Therapeutics Clinic. It is also envisioned that as more assays are have ready for clinical use", "butter_fingers": " asdays in development at SXIC-Frederick thcr coulv be imjediatelh transferred to accelerate ceduxtion to SOP-driven assays tfat can bv validatwd wmthin 6-12 months anv returncb to fme NCN hor clinical imklementation in the Develo[mdncal Therapeutics Clinic. It is also egvisionrd that as more wssajs are made ready for clinical use", "random_deletion": "assays in development at SAIC-Frederick that could transferred accelerate reduction SOP-driven assays that months returned to the for clinical implementation the Developmental Therapeutics Clinic. It is envisioned that as more assays are made ready for clinical use", "change_char_case": " assays in development at SAIC-frederick tHat coUld Be iMmEdiaTely Transferred to aCCeleRate reduction to SOP-drivEn assAyS That CAn Be valIdated wIThIN 6-12 MonThS aNd rEtURnEd to tHe NcI for clInical implEmeNtAtion in the DeVElOpmental ThEraPeutics CliniC. It Is also EnVisIOned tHat As morE assayS Are madE ready for ClINical uSE", "whitespace_perturbation": " assays in development atSAIC-Frede ricktha t c ou ld b e im mediately tran s ferr ed to accelerate reduc tionto SOP- d ri ven a ssays t h at c anbe  v ali da t ed  with in6-12 mo nths and r etu rn ed to the NC I  f or clinica l i mplementatio n i n theDe vel o pment alThera peutic s  Clini c. It isal s o envi s ioned t h a tas m ore assays are ma d er eady for clini cal us e", "underscore_trick": " assays_in development_at SAIC-Frederick that could_be immediately_transferred_to accelerate_reduction_to SOP-driven assays_that can be_validated within 6-12 months_and returned to_the_NCI for clinical implementation in the Developmental Therapeutics Clinic. It is also envisioned that_as_more assays_are_made_ready for clinical use"}
{"text": "ocytosis- and calpain-dependent FA disassembly. Surprisingly, 25% of the myosinII responsive FA proteome, including proteins involved in Rac-mediated lamellipodial protrusion, were enriched in FA by myosinII inhibition, establishing for the first time negative regulation of FA protein recruitment by contractility. We", "synonym_substitution": "ocytosis- and calpain - dependent FA disassembly. Surprisingly, 25% of the myosinII responsive FA proteome, include protein involved in Rac - mediated lamellipodial bulge, were enriched in FA by myosinII prohibition, establishing for the first prison term minus regulation of FA protein recruitment by contractility. We", "butter_fingers": "ocyhosis- and calpain-dependekt FA disassembli. Wurprivingly, 25% of the myosinII responsive FA protxome, inclyding proteins involvea in Rac-mvdiated lqmeloupodial protrusion, were skrichzd in FA by myoslnII inhibidion, establishhne yor the first time negative regulatijn of FS orotein recruijment fy ckntractility. We", "random_deletion": "ocytosis- and calpain-dependent FA disassembly. Surprisingly, 25% myosinII FA proteome, proteins involved in in by myosinII inhibition, for the first negative regulation of FA protein recruitment contractility. We", "change_char_case": "ocytosis- and calpain-dependeNt FA disassEmbly. surPriSiNgly, 25% Of thE myosinII respoNSive fA proteome, including proTeins InVOlveD In rac-meDiated lAMeLLIpoDiAl ProTrUSiOn, werE enRiched iN FA by myosiNII InHibition, estaBLiShing for thE fiRst time negatIve RegulaTiOn oF fA proTeiN recrUitmenT By contRactility. we", "whitespace_perturbation": "ocytosis- and calpain-depe ndent FA d isass emb ly.  S urpr isin gly, 25% of th e  myo sinII responsive FA pr oteom e, incl u di ng pr oteinsi nv o l ved  i nRac -m e di atedlam ellipod ial protru sio n,  were enrich e din FA by m yos inII inhibit ion , esta bl ish i ng fo r t he fi rst ti m e nega tive regu la t ion of FA prot e i nrecr uitment by contra c ti l ity. We", "underscore_trick": "ocytosis- and_calpain-dependent FA_disassembly. Surprisingly, 25% of_the myosinII_responsive_FA proteome,_including_proteins involved in_Rac-mediated lamellipodial protrusion,_were enriched in FA_by myosinII inhibition,_establishing_for the first time negative regulation of FA protein recruitment by contractility. We"}
{"text": "introduced at various locations throughout the ectodomain. Resulting BST-2 variants were tested for expression, dimerization, surface presentation, and inhibition of HIV-1 virus release. Consistent with the finding that BST-2 dimerization was not a prerequisite for cell surface expression, the vast majority of our B", "synonym_substitution": "introduced at various locations throughout the ectodomain. Resulting BST-2 random variable were quiz for expression, dimerization, surface presentation, and prohibition of HIV-1 virus release. Consistent with the finding that BST-2 dimerization was not a prerequisite for cellular telephone airfoil expression, the huge majority of our boron", "butter_fingers": "intgoduced at various locatlons throughout jhw ectovomain. Desultine BST-2 variants were tested flr exprtfsion, dimerization, surface iresentatuon, end inhibition oh HIV-1 vivbs remcase. Eoisistent with tme finding dhat BST-2 dimerhzxtnon was not a prerequisite for cell furface edpression, the dast iajodptn of our B", "random_deletion": "introduced at various locations throughout the ectodomain. variants tested for dimerization, surface presentation, release. with the finding BST-2 dimerization was a prerequisite for cell surface expression, vast majority of our B", "change_char_case": "introduced at various locatiOns throughOut thE ecTodOmAin. REsulTing BST-2 variantS Were Tested for expression, dimErizaTiON, surFAcE presEntatioN, AnD INhiBiTiOn oF Hiv-1 vIrus rEleAse. ConsIstent with The FiNding that BST-2 DImErization wAs nOt a prerequisIte For celL sUrfACe expResSion, tHe vast MAjoritY of our B", "whitespace_perturbation": "introduced at various loca tions thro ughou t t heec todo main . Resulting BS T -2 v ariants were tested fo r exp re s sion ,  d imeri zation, su r f ace  p re sen ta t io n, an d i nhibiti on of HIV- 1 v ir us release.C on sistent wi ththe findingtha t BST- 2dim e rizat ion  wasnot ap rerequ isite for  c e ll sur f ace exp r e ss ion,  the vast majorit y  o f  our B", "underscore_trick": "introduced at_various locations_throughout the ectodomain. Resulting_BST-2 variants_were_tested for_expression,_dimerization, surface presentation,_and inhibition of_HIV-1 virus release. Consistent_with the finding_that_BST-2 dimerization was not a prerequisite for cell surface expression, the vast majority of_our_B"}
{"text": " within the amino-terminus of the TACE pro-domain that attenuates TACE catalytic activity, independent of a cysteine switch mechanism, which provides new insight into the regulation of TACE enzymatic activity. We have also utilized a soluble TNF receptor (TNFR:Fc, Etanercept) in a clinical trial to", "synonym_substitution": "within the amino - terminus of the TACE pro - domain that attenuates TACE catalytic activity, autonomous of a cysteine substitution mechanism, which leave new insight into the rule of TACE enzymatic activity. We have also utilized a soluble TNF sense organ (TNFR: Fc, Etanercept) in a clinical test to", "butter_fingers": " wihhin the amino-terminus on the TACE pro-domain thet attehuates TXCE catalytic activity, indepxndebt of a cysteine switch mecfanism, whpch proviees iew insight into the regmjatikk of CARE enzymatic acjivity. We haee also utilizad a soluble TNF receptor (TNFR:Fc, Etanersept) in a clinical triaj to", "random_deletion": "within the amino-terminus of the TACE pro-domain TACE activity, independent a cysteine switch into regulation of TACE activity. We have utilized a soluble TNF receptor (TNFR:Fc, in a clinical trial to", "change_char_case": " within the amino-terminus of tHe TACE pro-dOmain ThaT atTeNuatEs TAcE catalytic actIVity, Independent of a cysteine SwitcH mEChanISm, Which ProvideS NeW INsiGhT iNto ThE ReGulatIon Of TACE eNzymatic acTivItY. We have also uTIlIzed a solubLe TnF receptor (TNfR:FC, EtaneRcEpt) IN a cliNicAl triAl to", "whitespace_perturbation": " within the amino-terminus  of the TA CE pr o-d oma in  tha t at tenuates TACEc atal ytic activity, indepen dentof a cy s te ine s witch m e ch a n ism ,wh ich  p r ov idesnew  insigh t into the  re gu lation of TA C Eenzymaticact ivity. We ha vealso u ti liz e d a s olu ble T NF rec e ptor ( TNFR:Fc,Et a nercep t ) in ac l in ical  trial to", "underscore_trick": " within_the amino-terminus_of the TACE pro-domain_that attenuates_TACE_catalytic activity,_independent_of a cysteine_switch mechanism, which_provides new insight into_the regulation of_TACE_enzymatic activity. We have also utilized a soluble TNF receptor (TNFR:Fc, Etanercept) in a_clinical_trial to"}
{"text": ". Although the formation of an intramolecular bond between a cysteine in the pro-domain and a zinc atom in the catalytic site had been thought to mediate this inhibitory activity, it was recently reported that the cysteine switch motif is not required. We hypothesized that the amino-terminus of the TACE pro-domain might contribute to", "synonym_substitution": ". Although the formation of an intramolecular bond between a cysteine in the pro - domain and a zinc atom in the catalytic site had been think to intercede this inhibitory activity, it was recently reported that the cysteine substitution motif is not want. We hypothesized that the amino - terminus of the TACE pro - domain might lend to", "butter_fingers": ". Alhhough the formation of xn intramoleculce bond betwesn a cysgeine in the pro-domain and a zunc aujm in the catalytiz site haf been tyougit to mediate thma inhiblcory zgtivicy, it was recentky reporteg that the cysdeknz switch motif is not required. We hy[othesiaef that the amigo-tegmynus of the TACE pro-domain might contrjbute tm", "random_deletion": ". Although the formation of an intramolecular a in the and a zinc had thought to mediate inhibitory activity, it recently reported that the cysteine switch is not required. We hypothesized that the amino-terminus of the TACE pro-domain might to", "change_char_case": ". Although the formation of an iNtramolecuLar boNd bEtwEeN a cySteiNe in the pro-domaIN and A zinc atom in the catalytiC site HaD Been THoUght tO mediatE ThIS InhIbItOry AcTIvIty, it Was RecentlY reported tHat ThE cysteine swiTCh Motif is not ReqUired. We hypotHesIzed thAt The AMino-tErmInus oF the TAce pro-doMain might CoNTributE To", "whitespace_perturbation": ". Although the formation o f an intra molec ula r b on d be twee n a cysteine i n  the  pro-domain and a zinc  atom  i n  the ca talyt ic site ha d bee nth oug ht to  medi ate  this i nhibitoryact iv ity, it wasr ec ently repo rte d that the c yst eine s wi tch motif  is  notrequir e d. Wehypothesi ze d  thatt he amin o - te rmin us of the TACE pr o -d o main might con tribut et o", "underscore_trick": ". Although_the formation_of an intramolecular bond_between a_cysteine_in the_pro-domain_and a zinc_atom in the_catalytic site had been_thought to mediate_this_inhibitory activity, it was recently reported that the cysteine switch motif is not required._We_hypothesized that_the_amino-terminus_of the TACE pro-domain might_contribute to"}
{"text": " body. We have expanded our research in this aim to the study of the large terminals of primary bipolar neurons from the retina. These terminals can be over 10 microns in diameter which make them ideal for studying the structure of the synaptic space. In these studies we discovered a new synaptic cytoskeletal structure. We found a thick", "synonym_substitution": "body. We have expanded our research in this aim to the discipline of the big terminals of primary bipolar neurons from the retina. These terminal can be over 10 microns in diameter which make them ideal for learn the social organization of the synaptic space. In these studies we discovered a new synaptic cytoskeletal structure. We find a thick", "butter_fingers": " bofy. We have expanded our vesearch in this aim to the sfudy of ghe large terminals of primacy bupolae neurons from the retkna. These terminaos cen be over 10 microns in dlcmeted whieh make them idesl for stugying the struwtjrz of the synaptic space. In these stuqies we dlscovered a ner symwptid cytoskeletal structure. We found z thick", "random_deletion": "body. We have expanded our research in to study of large terminals of retina. terminals can be 10 microns in which make them ideal for studying structure of the synaptic space. In these studies we discovered a new synaptic structure. We found a thick", "change_char_case": " body. We have expanded our reseArch in this Aim to The StuDy Of thE larGe terminals of pRImarY bipolar neurons from the RetinA. THEse tERmInals Can be ovER 10 mICRonS iN dIamEtER wHich mAke Them ideAl for studyIng ThE structure of THe Synaptic spAce. in these studiEs wE discoVeRed A New syNapTic cyToskelETal strUcture. We fOuND a thicK", "whitespace_perturbation": " body. We have expanded ou r research  in t his  ai mto t he s tudy of the la r ge t erminals of primary bi polar  n e uron s  f rom t he reti n a. T hes ete rmi na l scan b e o ver 10microns in  di am eter which m a ke  them idea l f or studyingthe  struc tu reo f the  sy napti c spac e . In t hese stud ie s  we di s covered a  n ew s ynaptic cytoskele t al structure. Wefoundat hi c k ", "underscore_trick": " body._We have_expanded our research in_this aim_to_the study_of_the large terminals_of primary bipolar_neurons from the retina._These terminals can_be_over 10 microns in diameter which make them ideal for studying the structure of_the_synaptic space._In_these_studies we discovered a new_synaptic cytoskeletal structure. We found_a thick"}
{"text": " data at year 5. Power analysis shows that extending the study will make it possible to observe effect sizes on the order of 0.05-0.10 with excellent power, in the range of at least 80-90%. [unreadable] [unreadable] [unreadable] The enteroendocrine cells, which comprise approximately", "synonym_substitution": "data at year 5. Power analysis testify that unfold the study will make it possible to note effect sizes on the club of 0.05 - 0.10 with excellent might, in the range of at least 80 - 90% . [ indecipherable ] [ indecipherable ] [ unreadable ] The enteroendocrine cells, which constitute approximately", "butter_fingers": " daha at year 5. Power analysls shows that exjebding vhe stusy will oake it possible to observe xffext sievs on the order of 0.05-0.10 wkth excelpent powwr, ii the range of av least 80-90%. [unreaswble] [nnreadable] [unresdable] The enteroendocrite czlls, which comprise approximately", "random_deletion": "data at year 5. Power analysis shows the will make possible to observe of with excellent power, the range of least 80-90%. [unreadable] [unreadable] [unreadable] The cells, which comprise approximately", "change_char_case": " data at year 5. Power analysis shOws that extEndinG thE stUdY wilL makE it possible to oBServE effect sizes on the order Of 0.05-0.10 witH eXCellENt Power, In the raNGe OF At lEaSt 80-90%. [UnrEaDAbLe] [unrEadAble] [unrEadable] The EntErOendocrine ceLLs, Which comprIse ApproximatelY", "whitespace_perturbation": " data at year 5. Power ana lysis show s tha t e xte nd ingthestudy will mak e  itpossible to observe ef fectsi z es o n  t he or der of0 .0 5 - 0.1 0wi thex c el lentpow er, inthe rangeofat  least 80-90 % .[unreadabl e][unreadable]  [u nreada bl e]T he en ter oendo crinec ells,which com pr i se app r oximate l y ", "underscore_trick": " data_at year_5. Power analysis shows_that extending_the_study will_make_it possible to_observe effect sizes_on the order of_0.05-0.10 with excellent_power,_in the range of at least 80-90%. [unreadable] [unreadable] [unreadable] The enteroendocrine cells, which_comprise_approximately"}
{"text": " the effects of either over expression of exogenous proteins, or down regulation of endogenous proteins, on compensatory endocytosis in developing sea urchin embryos. Using this assay we find that over expression of Src kinase, an oncogene, inhibits compensatory endocytosis. Inhibitors of tyrosine phosphatase had a similar effect, suggesting that the balance", "synonym_substitution": "the effects of either over expression of exogenous proteins, or down rule of endogenous protein, on compensatory endocytosis in develop sea urchin embryos. use this assay we find that over expression of Src kinase, an oncogene, inhibit compensatory endocytosis. inhibitor of tyrosine phosphatase had a similar effect, suggesting that the balance", "butter_fingers": " thf effects of either over expression of gxigenouv protsins, or aown regulation of endogenoud proteuns, on compensatory enaocytosis in deveoopiig sea urchin emudyos. Uslug thjd asvey we find that over exprassion of Src nivade, an oncogene, inhibits compensatorr endocutlsis. Inhibitorf of eyroapnt phosphatase had a similar effecf, suggevting that thr balance", "random_deletion": "the effects of either over expression of or regulation of proteins, on compensatory embryos. this assay we that over expression Src kinase, an oncogene, inhibits compensatory Inhibitors of tyrosine phosphatase had a similar effect, suggesting that the balance", "change_char_case": " the effects of either over expRession of eXogenOus ProTeIns, oR dowN regulation of eNDogeNous proteins, on compensaTory eNdOCytoSIs In devEloping SEa URChiN eMbRyoS. USInG this AssAy we finD that over eXprEsSion of Src kinASe, An oncogene, InhIbits compensAtoRy endoCyTosIS. InhiBitOrs of TyrosiNE phospHatase had A sIMilar eFFect, sugGEStIng tHat the balance", "whitespace_perturbation": " the effects of either ove r expressi on of  ex oge no us p rote ins, or down r e gula tion of endogenous pro teins ,o n co m pe nsato ry endo c yt o s isin  d eve lo p in g sea  ur chin em bryos. Usi ngth is assay wef in d that ove r e xpression of  Sr c kina se , a n  onco gen e, in hibits compen satory en do c ytosis .  Inhibi t o rs  oftyrosine phosphat a se had a similareffect ,s ug g e sti ngthat the b al ance", "underscore_trick": " the_effects of_either over expression of_exogenous proteins,_or_down regulation_of_endogenous proteins, on_compensatory endocytosis in_developing sea urchin embryos._Using this assay_we_find that over expression of Src kinase, an oncogene, inhibits compensatory endocytosis. Inhibitors of_tyrosine_phosphatase had_a_similar_effect, suggesting that the balance"}
{"text": "uses. There is now strong evidence that these proteins operate in conjunction with specific host factors. In fact, none of the HIV accessory proteins has a known catalytic activity. Instead, these proteins function primarily if not exclusively as molecular adaptors to link viral or cellular factors to pre-existing cellular pathways. In FY13 we continued", "synonym_substitution": "uses. There is now strong evidence that these protein engage in conjunction with specific host divisor. In fact, none of the HIV accessory protein has a known catalytic activity. alternatively, these proteins function chiefly if not entirely as molecular adaptors to link viral or cellular agent to pre - existing cellular pathways. In FY13 we continued", "butter_fingers": "used. There is now strong evldence that thesg proteiis operzte in cunjunction with specific hosv faxtors. In fact, none of the HKV accesslry protwins yas a knowi catalybnc acflvity. Mnstead, these ptoteins funcdion primarily iw uot exclusively as molecular adaptorf to limk viral or cellolar gwctods to pre-existing cellular pathwaya. In FY13 we continued", "random_deletion": "uses. There is now strong evidence that operate conjunction with host factors. In accessory has a known activity. Instead, these function primarily if not exclusively as adaptors to link viral or cellular factors to pre-existing cellular pathways. In FY13 continued", "change_char_case": "uses. There is now strong evideNce that theSe proTeiNs oPeRate In coNjunction with sPEcifIc host factors. In fact, nonE of thE Hiv accESsOry prOteins hAS a KNOwn CaTaLytIc ACtIvity. insTead, theSe proteins FunCtIon primarily IF nOt exclusivEly As molecular aDapTors to LiNk vIRal or CelLular FactorS To pre-eXisting ceLlULar patHWays. In Fy13 WE cOntiNued", "whitespace_perturbation": "uses. There is now strongevidence t hat t hes e p ro tein s op erate in conju n ctio n with specific host f actor s. In f a ct , non e of th e  H I V  ac ce ss ory  p r ot einshas  a know n catalyti c a ct ivity. Inste a d,  these pro tei ns functionpri marily  i f n o t exc lus ively  as mo l ecular  adaptors  t o  linkv iral or c el lula r factors to pre- e xi s ting cellularpathwa ys .  I n FY1 3 w e continue d", "underscore_trick": "uses. There_is now_strong evidence that these_proteins operate_in_conjunction with_specific_host factors. In_fact, none of_the HIV accessory proteins_has a known_catalytic_activity. Instead, these proteins function primarily if not exclusively as molecular adaptors to link_viral_or cellular_factors_to_pre-existing cellular pathways. In FY13_we continued"}
{"text": " the anesthetic sensitivity of whole animals has not been studied. To evaluate this issue in Drosophila, we acquired two insertion mutations that putatively depress gene function. To remove adventitious unlinked mutations in these strains, we extensively outcrossed them to our laboratory control strain. We then crossed the two lines to each other", "synonym_substitution": "the anesthetic sensitivity of whole animals has not been studied. To measure this consequence in Drosophila, we acquired two insertion mutation that putatively press down gene function. To remove adventitious unlinked mutant in these strains, we extensively outcrossed them to our laboratory control condition strain. We then crossed the two note to each other", "butter_fingers": " thf anesthetic sensitivity of whole animals has iot beeh studiea. To evaluate this issue in Vrosiphilq, we acquired two inseftion mutwtions tyat kutatively depress gene fmuctioh. To xenove adventitipus unlinkad mutations it ghzse strains, we extensively outcrosseq them yo our laboratori conuroj stdain. We then crossed the two lines to eaci other", "random_deletion": "the anesthetic sensitivity of whole animals has studied. evaluate this in Drosophila, we putatively gene function. To adventitious unlinked mutations these strains, we extensively outcrossed them our laboratory control strain. We then crossed the two lines to each other", "change_char_case": " the anesthetic sensitivity oF whole animAls haS noT beEn StudIed. TO evaluate this iSSue iN Drosophila, we acquired tWo insErTIon mUTaTions That putATiVELy dEpReSs gEnE FuNctioN. To Remove aDventitiouS unLiNked mutationS In These straiNs, wE extensively OutCrosseD tHem TO our lAboRatorY contrOL straiN. We then crOsSEd the tWO lines tO EAcH othEr", "whitespace_perturbation": " the anesthetic sensitivit y of whole  anim als  ha snotbeen  studied. To e v alua te this issue in Droso phila ,w e ac q ui red t wo inse r ti o n  mu ta ti ons  t h at  puta tiv ely dep ress genefun ct ion. To remo v eadventitio usunlinked mut ati ons in  t hes e  stra ins , weextens i vely o utcrossed  t h em too ur labo r a to ry c ontrol strain. We th e n crossed thetwo li ne s  t o eac h o ther", "underscore_trick": " the_anesthetic sensitivity_of whole animals has_not been_studied._To evaluate_this_issue in Drosophila,_we acquired two_insertion mutations that putatively_depress gene function._To_remove adventitious unlinked mutations in these strains, we extensively outcrossed them to our laboratory_control_strain. We_then_crossed_the two lines to each_other"}
{"text": " recovery are not kisspeptin responsive, while they do respond to GnRH, suggesting that pituitary responsiveness is intact. Thus, the acquisition and maintenance of kisspeptin responsiveness may play a role in reversal, and by extension in pubertal development (Lippincott, MF, et al, JCEM,", "synonym_substitution": "recovery are not kisspeptin responsive, while they do respond to GnRH, suggesting that pituitary responsiveness is integral. therefore, the acquisition and maintenance of kisspeptin responsiveness may toy a character in reversal, and by extension in pubertal exploitation (Lippincott, MF, et al, JCEM,", "butter_fingers": " refovery are not kisspeptik responsive, while they do reapond to GnRH, suggesting that pituitery eespobsiveness is intact. Thjs, the aceuisitiob anv maintenance of kisspepbnn reaionsireiess may play a role in raversal, and by ebtznsion in pubertal development (Lippigcott, MG, ft al, JCEM,", "random_deletion": "recovery are not kisspeptin responsive, while they to suggesting that responsiveness is intact. of responsiveness may play role in reversal, by extension in pubertal development (Lippincott, et al, JCEM,", "change_char_case": " recovery are not kisspeptin rEsponsive, wHile tHey Do rEsPond To GnrH, suggesting thAT pitUitary responsiveness is IntacT. THUs, thE AcQuisiTion and MAiNTEnaNcE oF kiSsPEpTin reSpoNsiveneSs may play a RolE iN reversal, and BY eXtension in PubErtal developMenT (LippiNcOtt, mf, et al, jCEm,", "whitespace_perturbation": " recovery are not kisspept in respons ive,whi leth ey d o re spond to GnRH, sugg esting that pituitaryrespo ns i vene s sis in tact. T h us , the  a cq uis it i on  andmai ntenanc e of kissp ept in  responsiven e ss  may playa r ole in rever sal , andby  ex t ensio n i n pub ertald evelop ment (Lip pi n cott,M F, et a l ,  J CEM, ", "underscore_trick": " recovery_are not_kisspeptin responsive, while they_do respond_to_GnRH, suggesting_that_pituitary responsiveness is_intact. Thus, the_acquisition and maintenance of_kisspeptin responsiveness may_play_a role in reversal, and by extension in pubertal development (Lippincott, MF, et al,_JCEM,"}
{"text": " resorbed soon thereafter. We subsequently determined that EpCAM was transiently expressed in conceptus-derived placentas with maximal expression at EGA 8.5-9.5. Detailed studies of placentas associated with EpCAM-deficient embryos revealed that they were small and thin with incompletely developed and poorly vascularized", "synonym_substitution": "resorbed soon thereafter. We subsequently determined that EpCAM was transiently expressed in conceptus - derive placenta with maximal expression at EGA 8.5 - 9.5. Detailed studies of placentas consort with EpCAM - deficient embryos uncover that they were small and thin with incompletely develop and poorly vascularized", "butter_fingers": " redorbed soon thereafter. Wt subsequently dejeemined that SpCAM war transiently expressed in clnxeptuw-derived placentas witf maximal expressuon et EGA 8.5-9.5. Detailed studies of plzgentav associated wijh EpCAM-defiwient embryos sexecled that they were small and thin wyth incpmoletely develoked amq pokgln vascularized", "random_deletion": "resorbed soon thereafter. We subsequently determined that transiently in conceptus-derived with maximal expression of associated with EpCAM-deficient revealed that they small and thin with incompletely developed poorly vascularized", "change_char_case": " resorbed soon thereafter. We sUbsequentlY deteRmiNed ThAt EpcAM wAs transiently eXPresSed in conceptus-derived pLacenTaS With MAxImal eXpressiON aT egA 8.5-9.5. DEtAiLed StUDiEs of pLacEntas asSociated wiTh EPCaM-deficient eMBrYos revealeD thAt they were smAll And thiN wIth INcompLetEly deVelopeD And pooRly vasculArIZed", "whitespace_perturbation": " resorbed soon thereafter.  We subseq uentl y d ete rm ined  tha t EpCAM was tr a nsie ntly expressed in conc eptus -d e rive d  p lacen tas wit h  m a x ima lex pre ss i on  at E GA8.5-9.5 . Detailed  st ud ies of place n ta s associat edwith EpCAM-d efi cientem bry o s rev eal ed th at the y  weresmall and  t h in wit h  incomp l e te ly d eveloped and poor l yv ascularized", "underscore_trick": " resorbed_soon thereafter._We subsequently determined that_EpCAM was_transiently_expressed in_conceptus-derived_placentas with maximal_expression at EGA_8.5-9.5. Detailed studies of_placentas associated with_EpCAM-deficient_embryos revealed that they were small and thin with incompletely developed and poorly vascularized"}
{"text": " a great potential in the development of implantable continuous glucose sensors for use in diabetes. We developed a procedure to control the size, compactness and stability of DNA nanoparticles by mediating the interaction between ions and DNA. We quantified the effects of salt, pH and temperature on their stability and biological activity. These polyplexes are", "synonym_substitution": "a great potential in the development of implantable continuous glucose sensors for habit in diabetes. We modernize a procedure to control the size, compactness and constancy of DNA nanoparticles by mediating the interaction between ions and deoxyribonucleic acid. We quantify the effects of strategic arms limitation talks, pH and temperature on their constancy and biological activity. These polyplexes are", "butter_fingers": " a hreat potential in the dtvelopment of implantablx contihuous gljcose sensors for use in diauetew. We eeveloped a procedure go controp the size, cinpactness ehd stabljity lf DUA nanoparticles by mediathng the interawtkou between ions and DNA. We quantified the efgefts of salt, pH and eempsgauure on their stability and biolofical abtivity. These poluplexes are", "random_deletion": "a great potential in the development of glucose for use diabetes. We developed size, and stability of nanoparticles by mediating interaction between ions and DNA. We the effects of salt, pH and temperature on their stability and biological activity. polyplexes are", "change_char_case": " a great potential in the develOpment of imPlantAblE coNtInuoUs glUcose sensors foR Use iN diabetes. We developed a pRocedUrE To coNTrOl the Size, comPAcTNEss AnD sTabIlITy Of DNA NanOparticLes by mediaTinG tHe interactioN BeTween ions aNd DnA. We quantifiEd tHe effeCtS of SAlt, pH And TempeRature ON their Stability AnD BiologICal actiVITy. thesE polyplexes are", "whitespace_perturbation": " a great potential in thedevelopmen t ofimp lan ta blecont inuous glucose sens ors for use in diabete s. We  d e velo p ed  a pr ocedure to c ont ro lthe  s i ze , com pac tness a nd stabili tyof  DNA nanopar t ic les by med iat ing the inte rac tion b et wee n  ions  an d DNA . We q u antifi ed the ef fe c ts ofs alt, pH a nd  tem perature on their st a bility and bio logica la ct i v ity . T hese polyp le xes a r e", "underscore_trick": " a_great potential_in the development of_implantable continuous_glucose_sensors for_use_in diabetes. We_developed a procedure_to control the size,_compactness and stability_of_DNA nanoparticles by mediating the interaction between ions and DNA. We quantified the effects_of_salt, pH_and_temperature_on their stability and biological_activity. These polyplexes are"}
{"text": " needed to evaluate whether further preventive measures are in order. My research in this area has addressed potential thyrotoxicity, neurodevelopmental toxicity, and more recently has uncovered an association with diabetes. TCDD is created inadvertently as a byproduct of chemical manufacturing or disposal. TCDD has been considered one of the", "synonym_substitution": "needed to evaluate whether further preventive measures are in decree. My inquiry in this area has addressed likely thyrotoxicity, neurodevelopmental toxicity, and more recently has uncover an association with diabetes. TCDD is created unwittingly as a by-product of chemical manufacturing or administration. TCDD has been consider one of the", "butter_fingers": " nefded to evaluate whether further prevenjice meavures zre in ofder. My research in this aree haw addeessed potential thyrogoxicity, jeurodevwlopnwntal toxirjty, and more dccentnb has uncovered an associdtion with diateged. TCDD is created inadvertently as w byprocuft of chemical manlfwctudpnn or disposal. TCDD has been consjdered mne of the", "random_deletion": "needed to evaluate whether further preventive measures order. research in area has addressed more has uncovered an with diabetes. TCDD created inadvertently as a byproduct of manufacturing or disposal. TCDD has been considered one of the", "change_char_case": " needed to evaluate whether fuRther preveNtive MeaSurEs Are iN ordEr. My research in THis aRea has addressed potentiAl thyRoTOxicITy, NeuroDevelopMEnTAL toXiCiTy, aNd MOrE receNtlY has uncOvered an asSocIaTion with diabETeS. TCDD is creAteD inadvertentLy aS a byprOdUct OF chemIcaL manuFacturINg or diSposal. TCDd hAS been cONsidereD ONe Of thE", "whitespace_perturbation": " needed to evaluate whethe r furtherpreve nti veme asur es a re in order. M y  res earch in this area has  addr es s ed p o te ntial  thyrot o xi c i ty,  n eu rod ev e lo pment altoxicit y, and mor e r ec ently has un c ov ered an as soc iation withdia betes.  T CDD is cr eat ed in advert e ntly a s a bypro du c t of c h emicalm a nu fact uring or disposal .  T C DD has been co nsider ed on e ofthe ", "underscore_trick": " needed_to evaluate_whether further preventive measures_are in_order._My research_in_this area has_addressed potential thyrotoxicity,_neurodevelopmental toxicity, and more_recently has uncovered_an_association with diabetes. TCDD is created inadvertently as a byproduct of chemical manufacturing or_disposal._TCDD has_been_considered_one of the"}
{"text": " of the viral life cycle. At the level of entry, resistance can be caused by polymorphisms in the cell surface receptors. After the gammaretrovirus enters the receptive cell, reverse transcription and translocation to the nucleus can be inhibited or altered by virus resistance factors Fv1, mApobec3, and TR", "synonym_substitution": "of the viral life cycle. At the level of entry, underground can be cause by polymorphisms in the cell surface sense organ. After the gammaretrovirus enters the receptive cellular telephone, reverse transcription and translocation to the nucleus can be suppress or altered by virus resistance agent Fv1, mApobec3, and TR", "butter_fingers": " of the viral life cycle. At the level of eurry, revistande can bd caused by polymorphisms in tye ceol surface receptors. Awter the hammareteovicus enters the rxdeptive cell, dcversz vranscription akd translocdtion to the ngcuebs can be inhibited or altered by viwus resoshance factors Sv1, mS[obed3, and TR", "random_deletion": "of the viral life cycle. At the entry, can be by polymorphisms in the enters the receptive reverse transcription and to the nucleus can be inhibited altered by virus resistance factors Fv1, mApobec3, and TR", "change_char_case": " of the viral life cycle. At the lEvel of entrY, resiStaNce CaN be cAuseD by polymorphisMS in tHe cell surface receptors. after ThE GammAReTroviRus enteRS tHE RecEpTiVe cElL, ReVerse TraNscriptIon and tranSloCaTion to the nucLEuS can be inhiBitEd or altered bY viRus resIsTanCE factOrs fv1, mApObec3, anD tR", "whitespace_perturbation": " of the viral life cycle.At the lev el of  en try ,resi stan ce can be caus e d by  polymorphisms in thecellsu r face re cepto rs. Aft e rt h e g am ma ret ro v ir us en ter s the r eceptive c ell ,reverse tran s cr iption and  tr anslocationtothe nu cl eus can b e i nhibi ted or altere d by viru sr esista n ce fact o r sFv1,  mApobec3, and TR ", "underscore_trick": " of_the viral_life cycle. At the_level of_entry,_resistance can_be_caused by polymorphisms_in the cell_surface receptors. After the_gammaretrovirus enters the_receptive_cell, reverse transcription and translocation to the nucleus can be inhibited or altered by_virus_resistance factors_Fv1,_mApobec3,_and TR"}
{"text": " cells. Key proteins we identified were Rabs and Rab effectors, SNARE proteins, and several SNARE modulators. The above mapping work was done on single images. Thus, to determine the cellular dynamics of these components we imaged the live-cell local changes of proteins at the exact moment of fusion. In these", "synonym_substitution": "cells. Key proteins we identified were Rabs and Rab effector, trap proteins, and several SNARE modulators. The above mapping study was done on single trope. Thus, to determine the cellular moral force of these component we imaged the alive - cell local changes of protein at the exact moment of fusion. In these", "butter_fingers": " cepls. Key proteins we idenuified were Rabs cbd Rab effecfors, SNAFE proteins, and several SNARX moeulatirs. The above mapping dork was fone on wingow images. Tihs, to dccermihc the rellular dynamigs of these components we ioayed the live-cell local changes of prjteins st the exact momgnt og fusjon. In these", "random_deletion": "cells. Key proteins we identified were Rabs effectors, proteins, and SNARE modulators. The on images. Thus, to the cellular dynamics these components we imaged the live-cell changes of proteins at the exact moment of fusion. In these", "change_char_case": " cells. Key proteins we identifIed were RabS and RAb eFfeCtOrs, SnARE Proteins, and sevERal SnARE modulators. The above MappiNg WOrk wAS dOne on Single iMAgES. thuS, tO dEteRmINe The ceLluLar dynaMics of thesE coMpOnents we imagED tHe live-cell LocAl changes of pRotEins at ThE exACt momEnt Of fusIon. In tHEse", "whitespace_perturbation": " cells. Key proteins we id entified w ere R abs  an dRabeffe ctors, SNARE p r otei ns, and several SNAREmodul at o rs.T he  abov e mappi n gw o rkwa sdon eo nsingl e i mages.Thus, to d ete rm ine the cell u la r dynamics  of  these compo nen ts weim age d  theliv e-cel l loca l  chang es of pro te i ns att he exac t mo ment  of fusion. In th e se ", "underscore_trick": " cells._Key proteins_we identified were Rabs_and Rab_effectors,_SNARE proteins,_and_several SNARE modulators._The above mapping_work was done on_single images. Thus,_to_determine the cellular dynamics of these components we imaged the live-cell local changes of_proteins_at the_exact_moment_of fusion. In these"}
{"text": " Laura Koehly). One such project examines these relational processes within families affected by and at risk of Type 2 Diabetes. This research is conducted in collaboration with Dr. Melanie Myers of Cincinnati Children's Hospital Medical Center. We have successfully recruited and completed 155 assessments since beginning this effort. During the reporting period, we", "synonym_substitution": "Laura Koehly). One such project examines these relational processes within families involve by and at hazard of Type 2 Diabetes. This research is conducted in collaboration with Dr. Melanie Myers of Cincinnati Children's Hospital Medical Center. We have successfully recruit and complete 155 assessments since beginning this attempt. During the reporting period, we", "butter_fingers": " Lakra Koehly). One such projtct examines thesg eelatimnal pdocesses within families affected by abd at risk of Type 2 Diabeter. This redearch iw coiducted in collaukration with Sv. Melcnme Myers of Cinginnati Chindren's Hospitan Oebical Center. We have successfully resruited ajd completed 155 wssexfmenfs since beginning this effort. Durjng the reporting petiod, we", "random_deletion": "Laura Koehly). One such project examines these within affected by at risk of is in collaboration with Melanie Myers of Children's Hospital Medical Center. We have recruited and completed 155 assessments since beginning this effort. During the reporting period,", "change_char_case": " Laura Koehly). One such project Examines thEse reLatIonAl ProcEsseS within familieS AffeCted by and at risk of Type 2 DIabetEs. tHis rESeArch iS conducTEd IN ColLaBoRatIoN WiTh Dr. MElaNie MyerS of CincinnAti chIldren's HospiTAl medical CenTer. we have succesSfuLly recRuIteD And coMplEted 155 aSsessmENts sinCe beginniNg THis effORt. DurinG THe RepoRting period, we", "whitespace_perturbation": " Laura Koehly). One such p roject exa mines  th ese  r elat iona l processes wi t hinfamilies affected by a nd at  r i sk o f  T ype 2  Diabet e s. T his  r es ear ch is  cond uct ed in c ollaborati onwi th Dr. Melan i eMyers of C inc innati Child ren 's Hos pi tal Medic alCente r. Weh ave su ccessfull yr ecruit e d and c o m pl eted  155 assessmentss in c e beginning th is eff or t .D u rin g t he reporti ng  peri o d, we", "underscore_trick": " Laura_Koehly). One_such project examines these_relational processes_within_families affected_by_and at risk_of Type 2_Diabetes. This research is_conducted in collaboration_with_Dr. Melanie Myers of Cincinnati Children's Hospital Medical Center. We have successfully recruited and_completed_155 assessments_since_beginning_this effort. During the reporting_period, we"}
{"text": " to expand our knowledge of genetic interactions that support biologic phenomena. We studied interactions between NRG1 and NMDA-glutamate pathway partners. NRG1 plays a role in brain development, neuronal function and is a SZ risk gene. We show an interaction between NRG1 and SZ which we validated using", "synonym_substitution": "to expand our knowledge of genetic interactions that confirm biological phenomena. We studied interaction between NRG1 and NMDA - glutamate nerve pathway partners. NRG1 plays a role in mind development, neuronal affair and is a SZ risk gene. We show an interaction between NRG1 and SZ which we validate using", "butter_fingers": " to expand our knowledge of genetic interaerions vhat sulport biulogic phenomena. We studied mnteeactiins between NRG1 and NMAA-glutamane pathwat pactners. NRG1 plays a role lu brajk devzlipment, neuronak function and is a SZ rhsy yene. We show an interaction between GRG1 and SX which we valydattd tsinf", "random_deletion": "to expand our knowledge of genetic interactions biologic We studied between NRG1 and a in brain development, function and is SZ risk gene. We show an between NRG1 and SZ which we validated using", "change_char_case": " to expand our knowledge of genEtic interaCtionS thAt sUpPort BiolOgic phenomena. WE StudIed interactions between nRG1 anD NmdA-glUTaMate pAthway pARtNERs. NrG1 PlAys A rOLe In braIn dEvelopmEnt, neuronaL fuNcTion and is a SZ RIsK gene. We shoW an Interaction bEtwEen NRG1 AnD SZ WHich wE vaLidatEd usinG", "whitespace_perturbation": " to expand our knowledge o f geneticinter act ion sthat  sup port biologicp heno mena. We studied inter actio ns betw e en  NRG1  and NM D A- g l uta ma te  pa th w ay  part ner s. NRG1  plays a r ole  i n brain deve l op ment, neur ona l function a ndis a S Zris k  gene . W e sho w an i n teract ion betwe en NRG1 a n d SZ wh i c hwe v alidated using", "underscore_trick": " to_expand our_knowledge of genetic interactions_that support_biologic_phenomena. We_studied_interactions between NRG1_and NMDA-glutamate pathway_partners. NRG1 plays a_role in brain_development,_neuronal function and is a SZ risk gene. We show an interaction between NRG1_and_SZ which_we_validated_using"}
{"text": " test the efficacy of IPT for obesity prevention among at-risk girls with social-adjustment problems and/or anxiety. We also have evaluated feasibility and acceptability of a preventive family-based interpersonal psychotherapy (FB-IPT) program (13). FB-IPT was compared to family-based health education (FB", "synonym_substitution": "test the efficacy of IPT for obesity prevention among at - risk girls with social - allowance trouble and/or anxiety. We also have evaluated feasibility and acceptability of a preventive family - base interpersonal psychotherapy (FB - IPT) program (13). FB - IPT was compared to class - based health education (FB", "butter_fingers": " tedt the efficacy of IPT fur obesity prevgnrion akong af-risk gifls with social-adjustment prlboems qnd/or anxiety. We also fave evallated feawibiouty and acrsptabillcy of w przvxntive family-baxed interparsonal psychodhdrcpy (FB-IPT) program (13). FB-IPT was compareq to fakipy-based health edubaeion (FB", "random_deletion": "test the efficacy of IPT for obesity at-risk with social-adjustment and/or anxiety. We acceptability a preventive family-based psychotherapy (FB-IPT) program FB-IPT was compared to family-based health (FB", "change_char_case": " test the efficacy of IPT for obEsity preveNtion AmoNg aT-rIsk gIrls With social-adjuSTmenT problems and/or anxiety. WE also HaVE evaLUaTed feAsibiliTY aND AccEpTaBilItY Of A prevEntIve famiLy-based intErpErSonal psychotHErApy (FB-IPT) prOgrAm (13). FB-IPT was coMpaRed to fAmIly-BAsed hEalTh eduCation (fb", "whitespace_perturbation": " test the efficacy of IPTfor obesit y pre ven tio namon g at -risk girls wi t h so cial-adjustment proble ms an d/ o r an x ie ty. W e alsoh av e eva lu at edfe a si bilit y a nd acce ptabilityofapreventive f a mi ly-based i nte rpersonal ps ych othera py  (F B -IPT)  pr ogram  (13). FB-IPT  was comp ar e d to f a mily-ba s e dheal th education (FB", "underscore_trick": " test_the efficacy_of IPT for obesity_prevention among_at-risk_girls with_social-adjustment_problems and/or anxiety._We also have_evaluated feasibility and acceptability_of a preventive_family-based_interpersonal psychotherapy (FB-IPT) program (13). FB-IPT was compared to family-based health education (FB"}
{"text": " cells are thought to differentiate immediately from the self-renewing Lgr5+ cells. Endocrine precursor cells differentiate toward mature hormone-producing endocrine cells that are classified into at least 15 different terminally differentiated lineages (or subsets) by their expression of specific peptide hormones. Although the molecular mechanisms that regulate the differentiation from the", "synonym_substitution": "cells are thought to differentiate immediately from the self - renewing Lgr5 + cell. hormone precursor cells differentiate toward fledged hormone - producing endocrine cell that are classify into at least 15 different terminally differentiated lineages (or subsets) by their construction of specific peptide hormones. Although the molecular mechanisms that baffle the specialization from the", "butter_fingers": " cepls are thought to diffeventiate immediajeoy frok the aelf-reneding Lgr5+ cells. Endocrine prerursir ceols differentiate towafd mature hormone-prodncing endocrine rslls that are glassnfmed into at leaxt 15 differant terminally dkfyerentiated lineages (or subsets) by treir exlrfssion of specyfic [eptjde hormones. Although the moleculad mechaiisms that regukate the differentiation fgom hhe", "random_deletion": "cells are thought to differentiate immediately from Lgr5+ Endocrine precursor differentiate toward mature classified at least 15 terminally differentiated lineages subsets) by their expression of specific hormones. Although the molecular mechanisms that regulate the differentiation from the", "change_char_case": " cells are thought to differenTiate immedIatelY frOm tHe Self-ReneWing Lgr5+ cells. EnDOcriNe precursor cells differEntiaTe TOwarD MaTure hOrmone-pROdUCIng EnDoCriNe CElLs thaT arE classiFied into at LeaSt 15 Different terMInAlly differEntIated lineageS (or SubsetS) bY thEIr expResSion oF speciFIc peptIde hormonEs. aLthougH The moleCULaR mecHanisms that regulaTE tHE differentiatiOn from ThE", "whitespace_perturbation": " cells are thought to diff erentiateimmed iat ely  f romtheself-renewingL gr5+  cells. Endocrine prec ursor  c e llsd if feren tiate t o wa r d  ma tu re  ho rm o ne -prod uci ng endo crine cell s t ha t are classi f ie d into atlea st 15 differ ent  termi na lly diffe ren tiate d line a ges (o r subsets )b y thei r  expres s i on  ofspecific peptideh or m ones. Although  the m ol e cu l a r m ech anisms tha tregul a te thed if f e r ent i ation from th e", "underscore_trick": " cells_are thought_to differentiate immediately from_the self-renewing_Lgr5+_cells. Endocrine_precursor_cells differentiate toward_mature hormone-producing endocrine_cells that are classified_into at least_15_different terminally differentiated lineages (or subsets) by their expression of specific peptide hormones. Although_the_molecular mechanisms_that_regulate_the differentiation from the"}
{"text": "-neutralizing serum antibodies and were strongly protected against challenge with a high dose of SARS. Another NDV was engineered to express the hemagglutinin HA glycoprotein of highly pathogenic avian H5N1 influenza virus (HPAIV) (NDV-HA). The NDV-HA virus was highly attenuated in AG", "synonym_substitution": "-neutralizing serum antibodies and were strongly protected against challenge with a high venereal disease of SARS. Another NDV was engineer to express the hemagglutinin HA glycoprotein of highly pathogenic avian H5N1 influenza virus (HPAIV) (NDV - HA). The NDV - HA virus was highly attenuated in AG", "butter_fingers": "-neuhralizing serum antibodits and were stronyoy provected zgainst zhallenge with a high dose oh SAES. Anither NDV was engineerdd to expgess the yemajglutinin HA glyrkproteik of glghly 'athogenic aviak H5N1 influetza virus (HPAIE) (VDR-HA). The NDV-HA virus was highly attentated im WG", "random_deletion": "-neutralizing serum antibodies and were strongly protected with high dose SARS. Another NDV hemagglutinin glycoprotein of highly avian H5N1 influenza (HPAIV) (NDV-HA). The NDV-HA virus was attenuated in AG", "change_char_case": "-neutralizing serum antibodiEs and were sTrongLy pRotEcTed aGainSt challenge witH A higH dose of SARS. Another NDV wAs engInEEred TO eXpresS the hemAGgLUTinIn hA GlyCoPRoTein oF hiGhly patHogenic aviAn H5n1 iNfluenza viruS (hPaIV) (NDV-HA). ThE NDv-HA virus was hIghLy atteNuAteD In AG", "whitespace_perturbation": "-neutralizing serum antibo dies and w ere s tro ngl yprot ecte d against chal l enge  with a high dose of S ARS.An o ther ND V was  engine e re d toex pr ess  t h ehemag glu tinin H A glycopro tei nof highly pa t ho genic avia n H 5N1 influenz a v irus ( HP AIV )  (NDV -HA ). Th e NDV- H A viru s was hig hl y  atten u ated in A G", "underscore_trick": "-neutralizing serum_antibodies and_were strongly protected against_challenge with_a_high dose_of_SARS. Another NDV_was engineered to_express the hemagglutinin HA_glycoprotein of highly_pathogenic_avian H5N1 influenza virus (HPAIV) (NDV-HA). The NDV-HA virus was highly attenuated in AG"}
{"text": " proteins and certain cytokines are significantly elevated in filarial disease with active infection but not in the other groups indicating that filarial infection induced increased production of these factors correlated with the development of filarial lymphatic pathology. Tissue fibrosis is also a hallmark of lymphatic filarial disease. Matrix metalloproteinases are a family of circulating and tissue", "synonym_substitution": "proteins and certain cytokines are significantly lift in filarial disease with active contagion but not in the other groups indicate that filarial contagion induced increased production of these factor correlated with the development of filarial lymphatic pathology. Tissue fibrosis is besides a authentication of lymphatic filarial disease. Matrix metalloproteinases are a family of circulating and tissue", "butter_fingers": " prlteins and certain cytoklnes are signifieqntly xlevates in filxrial disease with active inhectuon byt not in the other gruups indibating thqt fmlarial infectioi induced incrswsed 'roduction of tmese factorv correlated whtf che development of filarial lymphatis pathokohy. Tissue fibrjsis ys amso a hallmark of lymphatic filarizl diseese. Matrix metakloproteinases are a familj of circulating and tlssue", "random_deletion": "proteins and certain cytokines are significantly elevated disease active infection not in the infection increased production of factors correlated with development of filarial lymphatic pathology. Tissue is also a hallmark of lymphatic filarial disease. Matrix metalloproteinases are a family circulating and tissue", "change_char_case": " proteins and certain cytokinEs are signiFicanTly EleVaTed iN filArial disease wiTH actIve infection but not in thE otheR gROups INdIcatiNg that fILaRIAl iNfEcTioN iNDuCed inCreAsed proDuction of tHesE fActors correlATeD with the deVelOpment of filaRiaL lymphAtIc pATholoGy. TIssue FibrosIS is alsO a hallmarK oF LymphaTIc filarIAL dIseaSe. Matrix metalloprOTeINases are a familY of cirCuLAtING anD tiSsue", "whitespace_perturbation": " proteins and certain cyto kines aresigni fic ant ly  ele vate d in filariald isea se with active infecti on bu tn ot i n  t he ot her gro u ps i ndi ca ti ngth a tfilar ial  infect ion induce d i nc reased produ c ti on of thes e f actors corre lat ed wit hthe devel opm ent o f fila r ial ly mphatic p at h ology. Tissuef i br osis  is also a hallma r ko f lymphatic fi larial  d i se a s e.Mat rix metall op rotei n ases ar e  a f a mil y  of circulati ng and tiss u e", "underscore_trick": " proteins_and certain_cytokines are significantly elevated_in filarial_disease_with active_infection_but not in_the other groups_indicating that filarial infection_induced increased production_of_these factors correlated with the development of filarial lymphatic pathology. Tissue fibrosis is also_a_hallmark of_lymphatic_filarial_disease. Matrix metalloproteinases are a_family of circulating and tissue"}
{"text": " phase separation does not occur in cross-linked gels, we have overcome this limitation by cross-linking our biopolymers, greatly extending the range of ion concentrations over which the system remains stable. In previous studies, this new non-destructive procedure has been used to investigate cross-linked gels of a model synthetic polymer", "synonym_substitution": "phase separation does not occur in cross - linked gel, we have get the best this limitation by cross - linking our biopolymers, greatly run the range of ion concentrations over which the organization persist stable. In former study, this modern non - destructive procedure has been used to investigate cross - connect gels of a model synthetic polymer", "butter_fingers": " phwse separation does not uccur in cross-lnbked gxls, we gave ovefcome this limitation by crods-oinkibg our biopolymers, grextly extejding thw raige of ion conceifrations over ahick vhe system remalns stable. Hn previous stgdked, this new non-destructive procedure has bern used to invesjigatt cwoss-mpnjed gels of a model synthetic polymeg", "random_deletion": "phase separation does not occur in cross-linked have this limitation cross-linking our biopolymers, ion over which the remains stable. In studies, this new non-destructive procedure has used to investigate cross-linked gels of a model synthetic polymer", "change_char_case": " phase separation does not occUr in cross-lInked GelS, we HaVe ovErcoMe this limitatiON by cRoss-linking our biopolymErs, grEaTLy exTEnDing tHe range OF iON ConCeNtRatIoNS oVer whIch The systEm remains sTabLe. in previous stUDiEs, this new nOn-dEstructive prOceDure haS bEen USed to InvEstigAte croSS-linkeD gels of a mOdEL synthETic polyMER", "whitespace_perturbation": " phase separation does not  occur incross -li nke dgels , we  have overcome this  limitation by cross-l inkin go ur b i op olyme rs, gre a tl y ext en di ngth e  r angeofion con centration s o ve r which thes ys tem remain s s table. In pr evi ous st ud ies ,  this  ne w non -destr u ctiveprocedure  h a s been used to i nv esti gate cross-linked ge l s of a model s ynthet ic po l y mer ", "underscore_trick": " phase_separation does_not occur in cross-linked_gels, we_have_overcome this_limitation_by cross-linking our_biopolymers, greatly extending_the range of ion_concentrations over which_the_system remains stable. In previous studies, this new non-destructive procedure has been used to_investigate_cross-linked gels_of_a_model synthetic polymer"}
{"text": "onal nets (PNNs), play a role in limiting synaptic plasticity in area CA2. We found that in mouse CA2, PNNs surround pyramidal (excitatory) neurons and their excitatory synapses on dendritic spines. Importantly, we found that staining for PNNs increases during postnatal development and could be", "synonym_substitution": "onal nets (PNNs), play a role in limiting synaptic malleability in sphere CA2. We find that in shiner CA2, PNNs surround pyramidal (excitatory) nerve cell and their excitatory synapses on dendritic spine. Importantly, we discover that staining for PNNs addition during postnatal development and could be", "butter_fingers": "onap nets (PNNs), play a role ln limiting synaktuc plavticitg in arex CA2. We found that in mouse RA2, PBNs syrround pyramidal (excigatory) nelrons and themr excitatory syizpses ok densvitic wpines. Importaktly, we foutd that stainitg flr PNNs increases during postnatal qevelopkejt and could bg", "random_deletion": "onal nets (PNNs), play a role in plasticity area CA2. found that in (excitatory) and their excitatory on dendritic spines. we found that staining for PNNs during postnatal development and could be", "change_char_case": "onal nets (PNNs), play a role in liMiting synaPtic pLasTicItY in aRea Ca2. We found that in MOuse cA2, PNNs surround pyramidaL (exciTaTOry) nEUrOns anD their eXCiTATorY sYnApsEs ON dEndriTic Spines. IMportantly, We fOuNd that stainiNG fOr PNNs incrEasEs during postNatAl deveLoPmeNT and cOulD be", "whitespace_perturbation": "onal nets (PNNs), play a r ole in lim iting  sy nap ti c pl asti city in area C A 2. W e found that in mouseCA2,PN N s su r ro und p yramida l  ( e x cit at or y)ne u ro ns an d t heir ex citatory s yna ps es on dendri t ic  spines. I mpo rtantly, wefou nd tha tsta i ningfor  PNNs  incre a ses du ring post na t al dev e lopment a nd  cou ld be", "underscore_trick": "onal nets_(PNNs), play_a role in limiting_synaptic plasticity_in_area CA2._We_found that in_mouse CA2, PNNs_surround pyramidal (excitatory) neurons_and their excitatory_synapses_on dendritic spines. Importantly, we found that staining for PNNs increases during postnatal development_and_could be"}
{"text": " delayed, incomplete, or absent sexual maturation. Defining the physiology of GnRH secretion is critical to understanding the clinical heterogeneity of IGD, particularly in light of emerging gene discoveries that aim to elucidate genotype-phenotype correlations. Non-reproductive phenotypic features have been identified in some individuals, including anosmia, auditory defects", "synonym_substitution": "delayed, incomplete, or absent sexual maturation. define the physiology of GnRH secretion is critical to understand the clinical heterogeneity of IGD, particularly in light of emerging gene discovery that aim to elucidate genotype - phenotype correlation. Non - reproductive phenotypic feature have been identified in some individuals, admit anosmia, auditory defects", "butter_fingers": " depayed, incomplete, or absekt sexual maturajiin. Defmning tge physiulogy of GnRH secretion is ccitixal ti understanding the clknical henerogeneiry oh IGD, particularly in linkt of cmergnnj gene discoverles that aik to elucidate gdnltype-phenotype correlations. Non-reprjductivr ohenotypic feajures rave been identified in some individuams, incllding anosmia, audotory defects", "random_deletion": "delayed, incomplete, or absent sexual maturation. Defining of secretion is to understanding the in of emerging gene that aim to genotype-phenotype correlations. Non-reproductive phenotypic features have identified in some individuals, including anosmia, auditory defects", "change_char_case": " delayed, incomplete, or absent Sexual matuRatioN. DeFinInG the PhysIology of GnRH seCRetiOn is critical to understaNding ThE ClinICaL heteRogeneiTY oF igD, pArTiCulArLY iN lighT of EmerginG gene discoVerIeS that aim to elUCiDate genotyPe-pHenotype corrElaTions. NOn-RepROductIve PhenoTypic fEAtures Have been iDeNTified IN some inDIViDualS, including anosmia, AUdITory defects", "whitespace_perturbation": " delayed, incomplete, or a bsent sexu al ma tur ati on . De fini ng the physiol o gy o f GnRH secretion is cr itica lt o un d er stand ing the cl i n ica lhe ter og e ne ity o f I GD, par ticularlyinli ght of emerg i ng  gene disc ove ries that ai m t o eluc id ate genot ype -phen otypec orrela tions. No n- r eprodu c tive ph e n ot ypic  features have be e ni dentified in s ome in di v id u a ls,  in cluding an os mia,a uditory de f e c ts", "underscore_trick": " delayed,_incomplete, or_absent sexual maturation. Defining_the physiology_of_GnRH secretion_is_critical to understanding_the clinical heterogeneity_of IGD, particularly in_light of emerging_gene_discoveries that aim to elucidate genotype-phenotype correlations. Non-reproductive phenotypic features have been identified in_some_individuals, including_anosmia,_auditory_defects"}
{"text": " plasma membrane is incomplete. In this aim we sought to directly determine the structure of clathrin-coated vesicles responsible for endocytosis. By understanding how proteins that have been functionally implicated in endocytosis assemble together at the nanoscale we place decades of biochemistry, cell biology, and genetics into a physical model of membrane", "synonym_substitution": "plasma membrane is incomplete. In this aim we sought to directly determine the social organization of clathrin - coat vesicles responsible for endocytosis. By understand how protein that have been functionally implicated in endocytosis assemble together at the nanoscale we identify decades of biochemistry, cell biota, and genetics into a forcible model of membrane", "butter_fingers": " plwsma membrane is incompltte. In this aim wg wought to didectly ddtermine the structure of clethrun-coauvd vesicles responsibue for enfocytosiw. By ynderstandmhg how ixoteihd thct have been fungtionally ikplicated in etducvtosis assemble together at the nanofcale wr olace decades jf bposhemjstry, cell biology, and genetics info a phjsical model of mrmbrane", "random_deletion": "plasma membrane is incomplete. In this aim to determine the of clathrin-coated vesicles how that have been implicated in endocytosis together at the nanoscale we place of biochemistry, cell biology, and genetics into a physical model of membrane", "change_char_case": " plasma membrane is incompletE. In this aim We souGht To dIrEctlY detErmine the strucTUre oF clathrin-coated vesicleS respOnSIble FOr EndocYtosis. BY UnDERstAnDiNg hOw PRoTeins ThaT have beEn functionAllY iMplicated in eNDoCytosis assEmbLe together at The NanoscAlE we PLace dEcaDes of BiocheMIstry, cEll biologY, aND genetICs into a PHYsIcal Model of membrane", "whitespace_perturbation": " plasma membrane is incomp lete. In t his a imweso ught  todirectly deter m inethe structure of clath rin-c oa t ed v e si clesrespons i bl e for  e nd ocy to s is . Byund erstand ing how pr ote in s that haveb ee n function all y implicated  in  endoc yt osi s  asse mbl e tog ethera t thenanoscale  w e  place decades o fbioc hemistry, cell bi o lo g y, and genetic s into  a ph y s ica l m odel of me mb rane", "underscore_trick": " plasma_membrane is_incomplete. In this aim_we sought_to_directly determine_the_structure of clathrin-coated_vesicles responsible for_endocytosis. By understanding how_proteins that have_been_functionally implicated in endocytosis assemble together at the nanoscale we place decades of biochemistry,_cell_biology, and_genetics_into_a physical model of membrane"}
{"text": " transcriptome and proteomic analysis of sorted CD5hi and CD5lo T cells as well as using next-gen sequencing of TCR from such sorted T cells. Tumor necrosis factor (TNF) is a multifunctional cytokine that may play an important role in the pathogenesis of lung inflammation. TNF bioactivity is regulated by soluble TNF", "synonym_substitution": "transcriptome and proteomic analysis of sorted CD5hi and CD5lo T cells as well as use future - gen sequencing of TCR from such sorted T cell. Tumor necrosis factor (TNF) is a multifunctional cytokine that may play an significant role in the pathogenesis of lung inflammation. TNF bioactivity is regulate by soluble TNF", "butter_fingers": " trwnscriptome and proteomig analysis of sottwd CD5hm and CS5lo T ceuls as well as using next-gen swquenxing of TCR from such rorted T bells. Tumir ntcrosis factor (TNH) is a mmjtifhkctiouao cytokine thaj may play at important rone iu the pathogenesis of lung inflammatyon. TNF bloactivity is tegulseed gj woluble TNF", "random_deletion": "transcriptome and proteomic analysis of sorted CD5hi T as well using next-gen sequencing T Tumor necrosis factor is a multifunctional that may play an important role the pathogenesis of lung inflammation. TNF bioactivity is regulated by soluble TNF", "change_char_case": " transcriptome and proteomic Analysis of SorteD CD5Hi aNd cD5lo t celLs as well as usinG Next-Gen sequencing of TCR from Such sOrTEd T cELlS. TumoR necrosIS fACTor (tNf) iS a mUlTIfUnctiOnaL cytokiNe that may pLay An Important rolE In The pathogeNesIs of lung inflAmmAtion. TnF BioACtiviTy iS reguLated bY SolublE TNF", "whitespace_perturbation": " transcriptome and proteom ic analysi s ofsor ted  C D5hi  and  CD5lo T cells as w ell as using next-genseque nc i ng o f  T CR fr om such so r t edTce lls .T um or ne cro sis fac tor (TNF)isamultifunctio n al  cytokinetha t may play a n i mporta nt  ro l e inthe  path ogenes i s of l ung infla mm a tion.T NF bioa c t iv ityis regulated by s o lu b le TNF", "underscore_trick": " transcriptome_and proteomic_analysis of sorted CD5hi_and CD5lo_T_cells as_well_as using next-gen_sequencing of TCR_from such sorted T_cells. Tumor necrosis_factor_(TNF) is a multifunctional cytokine that may play an important role in the pathogenesis_of_lung inflammation._TNF_bioactivity_is regulated by soluble TNF"}
{"text": " level of CD5 expression to monitor the affinity of a specific TCR for self-MHC ligands. Using a variety of methods including analysis of partial TCR-associated zeta-chain phosphorylation, we found that we could readily classify T cells according to their self-ligand affinity by this means. Using new methods for assessing", "synonym_substitution": "level of CD5 expression to monitor the affinity of a specific TCR for self - MHC ligands. Using a variety show of method including analysis of partial TCR - consort zeta - chain phosphorylation, we found that we could promptly classify T cells harmonize to their self - ligand affinity by this means. Using modern methods for assessing", "butter_fingers": " legel of CD5 expression to oonitor the affnbity oh a spedific TCF for self-MHC ligands. Using e vaeiety of methods including xnalysis lf partiql TRR-associated zete-dhain pmjsphkvylatnoi, we found that we could seadily classixy T cells according to their self-liganq affinotj by this meanf. Uspnd nes methods for assessing", "random_deletion": "level of CD5 expression to monitor the a TCR for ligands. Using a of TCR-associated zeta-chain phosphorylation, found that we readily classify T cells according to self-ligand affinity by this means. Using new methods for assessing", "change_char_case": " level of CD5 expression to moniTor the affiNity oF a sPecIfIc TCr for Self-MHC ligands. uSing A variety of methods incluDing aNaLYsis OF pArtiaL TCR-assOCiATEd zEtA-cHaiN pHOsPhoryLatIon, we foUnd that we cOulD rEadily classiFY T Cells accorDinG to their self-LigAnd affInIty BY this MeaNs. UsiNg new mEThods fOr assessiNg", "whitespace_perturbation": " level of CD5 expression t o monitorthe a ffi nit yof a  spe cific TCR fors elf- MHC ligands. Using a v ariet yo f me t ho ds in cluding an a l ysi sof  pa rt i al  TCR- ass ociated  zeta-chai n p ho sphorylation ,  w e found th atwe could rea dil y clas si fyT  cell s a ccord ing to theirself-liga nd affini t y by th i s  m eans . Using new metho d sf or assessing", "underscore_trick": " level_of CD5_expression to monitor the_affinity of_a_specific TCR_for_self-MHC ligands. Using_a variety of_methods including analysis of_partial TCR-associated zeta-chain_phosphorylation,_we found that we could readily classify T cells according to their self-ligand affinity_by_this means._Using_new_methods for assessing"}
{"text": " overexpression of STV protein causes abnormally long strings of synaptic boutons. Responses to repetitive stimulation are abnormal both in stv mutants and upon stv overexpression. These phenotypes provide fresh insight into the role of this poorly understood co-chaperone in neural development as well as regulated exocytosis. 3) TDP", "synonym_substitution": "overexpression of STV protein causes abnormally long strings of synaptic boutons. Responses to insistent foreplay are abnormal both in stv mutant and upon stv overexpression. These phenotypes leave clean insight into the role of this ill understood co - chaperone in nervous growth as well as baffle exocytosis. 3) TDP", "butter_fingers": " ovfrexpression of STV prottin causes abnormcoly loig strihgs of shnaptic boutons. Responses to rwpetiupve stimulation are acnormal blth in srv mntants and upon stv overcrpresalon. Tkewe phenotypes krovide fresv insight into tfe role of this poorly understood co-craperonr ln neural devejopmtnt as svlo as regulated exocytosis. 3) TDL", "random_deletion": "overexpression of STV protein causes abnormally long synaptic Responses to stimulation are abnormal upon overexpression. These phenotypes fresh insight into role of this poorly understood co-chaperone neural development as well as regulated exocytosis. 3) TDP", "change_char_case": " overexpression of STV proteiN causes abnOrmalLy lOng StRingS of sYnaptic boutons. rEspoNses to repetitive stimulAtion ArE AbnoRMaL both In stv muTAnTS And UpOn Stv OvEReXpresSioN. These pHenotypes pRovIdE fresh insighT InTo the role oF thIs poorly undeRstOod co-cHaPerONe in nEurAl devElopmeNT as welL as regulaTeD ExocytOSis. 3) TDP", "whitespace_perturbation": " overexpression of STV pro tein cause s abn orm all ylong  str ings of synapt i c bo utons. Responses to re petit iv e  sti m ul ation  are ab n or m a l b ot hinst v  m utant s a nd upon  stv overe xpr es sion. Thesep he notypes pr ovi de fresh ins igh t into  t her ole o f t his p oorlyu nderst ood co-ch ap e rone i n  neural d ev elop ment as well as r e gu l ated exocytosi s. 3)TD P ", "underscore_trick": " overexpression_of STV_protein causes abnormally long_strings of_synaptic_boutons. Responses_to_repetitive stimulation are_abnormal both in_stv mutants and upon_stv overexpression. These_phenotypes_provide fresh insight into the role of this poorly understood co-chaperone in neural development_as_well as_regulated_exocytosis._3) TDP"}
{"text": " or Hepatoblast (HB) signatures which have been described previously. The Jun signature was significantly associated with patient survival. The gene expression signature in tumors derived from Jun-KO livers was close to the group of human HCC with a better survival. These tumors exhibited a greater apoptotic index. In the future, we will", "synonym_substitution": "or Hepatoblast (HB) signatures which have been described previously. The Jun signature was significantly consociate with patient survival. The gene formula signature in tumors derived from Jun - KO liver was close to the group of human HCC with a better survival. These tumor exhibited a greater apoptotic index. In the future, we will", "butter_fingers": " or Hepatoblast (HB) signaturts which have beeu descrmbed prsviously. The Jun signature was signihicabtly qssociated with patieng survivap. The gebe eepression signatnde in tmiors ferirev from Jun-KO liyers was clmse to the grogp oy human HCC with a better survival. Trese tukogs exhibited a greseer zioktotic index. In the future, we wilm", "random_deletion": "or Hepatoblast (HB) signatures which have been The signature was associated with patient in derived from Jun-KO was close to group of human HCC with a survival. These tumors exhibited a greater apoptotic index. In the future, we will", "change_char_case": " or Hepatoblast (HB) signatures Which have bEen deScrIbeD pReviOuslY. The Jun signatuRE was Significantly associateD with PaTIent SUrVival. the gene EXpRESsiOn SiGnaTuRE iN tumoRs dErived fRom Jun-KO liVerS wAs close to the GRoUp of human HcC wIth a better suRviVal. TheSe TumORs exhIbiTed a gReater APoptotIc index. In ThE Future, WE will", "whitespace_perturbation": " or Hepatoblast (HB) signa tures whic h hav e b een  d escr ibed  previously. T h e Ju n signature was signif icant ly asso c ia ted w ith pat i en t sur vi va l.Th e  g ene e xpr essionsignatureintu mors derived fr om Jun-KOliv ers was clos e t o thegr oup of hu man  HCCwith a better  survival .T hese t u mors ex h i bi teda greater apoptot i ci ndex. In the f uture,  w e  w i l l", "underscore_trick": " or_Hepatoblast (HB)_signatures which have been_described previously._The_Jun signature_was_significantly associated with_patient survival. The_gene expression signature in_tumors derived from_Jun-KO_livers was close to the group of human HCC with a better survival. These_tumors_exhibited a_greater_apoptotic_index. In the future, we_will"}
{"text": ". The mechanisms underlying the profound modulation of parasite antigen-specific human T cell responses in lymphatic filariasis have been addressed by demonstrating the multiple pathways involved. While several mechanisms have been implicated in mediating this T cell specific downregulation, the role for alterations in the homeostasis of T effector and memory cell populations was explored using multipar", "synonym_substitution": ". The mechanisms underlying the profound modulation of parasite antigen - specific human metric ton cellular telephone responses in lymphatic filariasis have been addressed by attest the multiple pathway involved. While several mechanism have been entail in mediating this thymine cell specific downregulation, the role for revision in the homeostasis of T effector and memory cell population was explored use multipar", "butter_fingers": ". Thf mechanisms underlying uhe profound modulation mf parzsite angigen-specific human T cell rxspobses un lymphatic filariasir have bevn addreswed uy demonstrating the mulbnple lwthwcyw involved. Whike several mechanisms haee bzen implicated in mediating this T cqll spevivic downregulajion, uhe rols for alterations in the homeostasjs of T effector and memory cell populations wws edplored using multlpar", "random_deletion": ". The mechanisms underlying the profound modulation antigen-specific T cell in lymphatic filariasis the pathways involved. While mechanisms have been in mediating this T cell specific the role for alterations in the homeostasis of T effector and memory cell was explored using multipar", "change_char_case": ". The mechanisms underlying thE profound mOdulaTioN of PaRasiTe anTigen-specific hUMan T Cell responses in lymphatIc filArIAsis HAvE been AddressED bY DEmoNsTrAtiNg THe MultiPle PathwayS involved. WHilE sEveral mechanISmS have been iMplIcated in mediAtiNg this t cEll SPecifIc dOwnreGulatiON, the roLe for alteRaTIons in THe homeoSTAsIs of t effector and memorY CeLL populations waS exploReD UsING muLtiPar", "whitespace_perturbation": ". The mechanisms underlyin g the prof oundmod ula ti on o f pa rasite antigen - spec ific human T cell resp onses  i n  lym p ha tic f ilarias i sh a vebe en  ad dr e ss ed by  de monstra ting the m ult ip le pathwaysi nv olved. Whi leseveral mech ani sms ha ve  be e n imp lic atedin med i atingthis T ce ll specif i c downr e g ul atio n, the role for a l te r ations in thehomeos ta s is o f T  ef fector and  m emory cell po p ul a t i ons was exploredusing multi p ar", "underscore_trick": ". The_mechanisms underlying_the profound modulation of_parasite antigen-specific_human_T cell_responses_in lymphatic filariasis_have been addressed_by demonstrating the multiple_pathways involved. While_several_mechanisms have been implicated in mediating this T cell specific downregulation, the role for_alterations_in the_homeostasis_of_T effector and memory cell_populations was explored using multipar"}
{"text": "v2-DT390 (96.5 KDa) will be produced using the yeast Pichia pastoris expression system, as previously described for anti-CD3-DT390. Evaluation of in vitro and in vivo rhesus macaque HSPC target cytotoxicity and pharmacokinetic studies will be performed in FY20. P", "synonym_substitution": "v2 - DT390 (96.5 KDa) will be produced using the yeast Pichia pastoris expression system, as previously trace for anti - CD3 - DT390. Evaluation of in vitro and in vivo rhesus macaque HSPC prey cytotoxicity and pharmacokinetic studies will be performed in FY20. P", "butter_fingers": "v2-DT390 (96.5 KDa) will be produced uring the yeast Kixhia pestoris expresskon system, as previously desrribwd foe anti-CD3-DT390. Evaluation uf in vitgo and in vivi rhesus marzque HSIE tarfct cycovoxicity and phsrmacokinedic studies winl bz performed in FY20. P", "random_deletion": "v2-DT390 (96.5 KDa) will be produced using Pichia expression system, previously described for and vivo rhesus macaque target cytotoxicity and studies will be performed in FY20.", "change_char_case": "v2-DT390 (96.5 KDa) will be produced using The yeast PiChia pAstOriS eXpreSsioN system, as previOUsly Described for anti-CD3-DT390. EvAluatIoN Of in VItRo and In vivo rHEsUS MacAqUe hSPc tARgEt cytOtoXicity aNd pharmacoKinEtIc studies wilL Be Performed iN FY20. p", "whitespace_perturbation": "v2-DT390 (96.5 KDa) will b e produced  usin g t heye astPich ia pastoris ex p ress ion system, as previou sly d es c ribe d  f or an ti-CD3- D T3 9 0 . E va lu ati on of  in v itr o and i n vivo rhe sus  m acaque HSPCt ar get cytoto xic ity and phar mac okinet ic  st u dieswil l beperfor m ed inFY20. P", "underscore_trick": "v2-DT390 (96.5_KDa) will_be produced using the_yeast Pichia_pastoris_expression system,_as_previously described for_anti-CD3-DT390. Evaluation of_in vitro and in_vivo rhesus macaque_HSPC_target cytotoxicity and pharmacokinetic studies will be performed in FY20. P"}
{"text": "-Frederick's application of technical expertise in diagnostic testing, a number of validated assays are already in the clinic or moving into the clinic at this time, including assays for PARP target function, PARP pathway expression, DNA damage by chemotherapeutic agents, DNA methylation, tumor cellularity, tumor stem cell identification and", "synonym_substitution": "-Frederick's application of technical expertise in diagnostic testing, a number of validate assay are already in the clinic or moving into the clinic at this time, including assay for PARP target function, PARP nerve pathway expression, DNA damage by chemotherapeutic agent, DNA methylation, tumor cellularity, tumor stem cellular telephone identification and", "butter_fingers": "-Freferick's application of ttchnical expertisg un diajnostic testing, a number of validated assayd qre aoready in the clinic of moving pnto the xlinmc at this time, mhcludinn asszns fox 'ARP target fungtion, PARP [athway expresviun, DNA damage by chemotherapeutic agegts, DNA mfthylation, tumjr ctlltlarjny, tumor stem cell identificatikn and", "random_deletion": "-Frederick's application of technical expertise in diagnostic number validated assays already in the clinic this time, including for PARP target PARP pathway expression, DNA damage by agents, DNA methylation, tumor cellularity, tumor stem cell identification and", "change_char_case": "-Frederick's application of teChnical expErtisE in DiaGnOstiC tesTing, a number of vALidaTed assays are already in tHe cliNiC Or moVInG into The clinIC aT THis TiMe, IncLuDInG assaYs fOr PARP tArget functIon, pArP pathway expREsSion, DNA damAge By chemotheraPeuTic ageNtS, DNa MethyLatIon, tuMor celLUlaritY, tumor steM cELl idenTIficatiON AnD", "whitespace_perturbation": "-Frederick's application o f technica l exp ert ise  i n di agno stic testing,a  num ber of validated assay s are  a l read y  i n the  clinic or m ovi ng  i nto  t h eclini c a t thistime, incl udi ng  assays forP AR P target f unc tion, PARP p ath way ex pr ess i on, D NAdamag e by c h emothe rapeuticag e nts, D N A methy l a ti on,tumor cellularity ,  t u mor stem cellidenti fi c at i o n a nd", "underscore_trick": "-Frederick's application_of technical_expertise in diagnostic testing,_a number_of_validated assays_are_already in the_clinic or moving_into the clinic at_this time, including_assays_for PARP target function, PARP pathway expression, DNA damage by chemotherapeutic agents, DNA methylation,_tumor_cellularity, tumor_stem_cell_identification and"}
{"text": " FRET reactions. 3. The third methodological project investigates how FRET efficiencies change when multiple acceptors are present. This type of problem is important, because many proteins form multi-meric complexes, and the assembly and disassembly of these complexes might play an important role in regulating cell functions. The accepted mathematical formalism for", "synonym_substitution": "FRET reactions. 3. The third methodological project investigates how FRET efficiencies change when multiple acceptor are present. This character of problem is important, because many protein form multi - meric building complex, and the assembly and disassembly of these complex might play an important function in regulating cell function. The accepted mathematical formalism for", "butter_fingers": " FRFT reactions. 3. The third oethodological kriject mnvestifates hod FRET efficiencies change wien nultikje acceptors are pfesent. Thps type od privlem is im'krtant, nzcauss manv 'roteins form molti-meric cokplexes, and tha xsdembly and disassembly of these com[lexes kihht play an imkortame romv ln regulating cell functions. The accepttd mathematical fotmalism for", "random_deletion": "FRET reactions. 3. The third methodological project FRET change when acceptors are present. important, many proteins form complexes, and the and disassembly of these complexes might an important role in regulating cell functions. The accepted mathematical formalism for", "change_char_case": " FRET reactions. 3. The third methOdological ProjeCt iNveStIgatEs hoW FRET efficiencIEs chAnge when multiple acceptOrs arE pREsenT. thIs typE of probLEm IS ImpOrTaNt, bEcAUsE many ProTeins foRm multi-merIc cOmPlexes, and the ASsEmbly and diSasSembly of thesE coMplexeS mIghT Play aN imPortaNt role IN regulAting cell FuNCtions. tHe accepTED mAtheMatical formalism fOR", "whitespace_perturbation": " FRET reactions. 3. The th ird method ologi cal  pr oj ectinve stigates how F R ET e fficiencies change whe n mul ti p le a c ce ptors  are pr e se n t . T hi styp eo fprobl emis impo rtant, bec aus emany protein s  f orm multi- mer ic complexes , a nd the  a sse m bly a nddisas sembly of the se comple xe s  might play an i mp orta nt role in regula t in g  cell function s. The  a c ce p t edmat hematicalfo rmali s m for", "underscore_trick": " FRET_reactions. 3._The third methodological project_investigates how_FRET_efficiencies change_when_multiple acceptors are_present. This type_of problem is important,_because many proteins_form_multi-meric complexes, and the assembly and disassembly of these complexes might play an important_role_in regulating_cell_functions._The accepted mathematical formalism for"}
{"text": " biological activity of DNA nanoparticles, we believe that this knowledge can provide a solid foundation for developing new DNA-based vaccines for the treatment of various diseases. We studied the effect of calcium ions on the larger scale structure of DNA solutions and gels in near-physiological salt conditions by SANS. Analysis of the SANS response", "synonym_substitution": "biological activity of DNA nanoparticles, we believe that this knowledge can leave a upstanding foundation for developing new DNA - base vaccines for the treatment of versatile disease. We studied the effect of calcium ions on the larger scale social organization of DNA solutions and gels in near - physiologic salt conditions by SANS. psychoanalysis of the SANS response", "butter_fingers": " billogical activity of DNA nanoparticles, cw belixve thaf this kvowledge can provide a solid fiundaupon for developing ned DNA-basef vaccinws fie the treavjent of variohd divxases. We studiec the effewt of calcium hovs on the larger scale structure of DGA soluyilns and gels ig nesw-phyapooogical salt conditions by SAHS. Analjsis of the SANS tesponse", "random_deletion": "biological activity of DNA nanoparticles, we believe knowledge provide a foundation for developing treatment various diseases. We the effect of ions on the larger scale structure DNA solutions and gels in near-physiological salt conditions by SANS. Analysis of the response", "change_char_case": " biological activity of DNA naNoparticleS, we beLieVe tHaT thiS knoWledge can proviDE a soLid foundation for develoPing nEw dnA-baSEd VacciNes for tHE tREAtmEnT oF vaRiOUs DiseaSes. we studiEd the effecT of CaLcium ions on tHE lArger scale StrUcture of DNA sOluTions aNd GelS In neaR-phYsiolOgical SAlt conDitions by sAns. AnalySIs of the sanS RespOnse", "whitespace_perturbation": " biological activity of DN A nanopart icles , w e b el ieve  tha t this knowled g e ca n provide a solid foun datio nf or d e ve lopin g new D N A- b a sed  v ac cin es fo r the  tr eatment  of variou s d is eases. We st u di ed the eff ect  of calciumion s on t he  la r ger s cal e str ucture of DNA  solution sa nd gel s  in nea r - ph ysio logical salt cond i ti o ns by SANS. An alysis  o f  t h e  SA NSresponse", "underscore_trick": " biological_activity of_DNA nanoparticles, we believe_that this_knowledge_can provide_a_solid foundation for_developing new DNA-based_vaccines for the treatment_of various diseases._We_studied the effect of calcium ions on the larger scale structure of DNA solutions_and_gels in_near-physiological_salt_conditions by SANS. Analysis of_the SANS response"}
{"text": "integrative deficits that reflect genetic risk mechanisms for SZ. These deficits are mildly present in siblings and normal controls with the risk-associated genotype. This suggests that altered PFC activation and coupling are independent intermediate phenotypes, one of which is modulated by susceptibility genes. A SNP in ZNF804A appears to modulate PFC", "synonym_substitution": "integrative deficits that reflect genetic hazard mechanism for SZ. These deficits are mildly present in sibling and normal controls with the hazard - associated genotype. This suggests that interpolate PFC energizing and coupling are independent intermediate phenotypes, one of which is modulated by susceptibility gene. A SNP in ZNF804A appears to modulate PFC", "butter_fingers": "intfgrative deficits that rtflect genetic risk mechenisms ror SZ. Tfese deficits are mildly predebt in siblings and normal cuntrols wpth the rusk-awwociated gxhotype. Bkis shngestv that altered KFC activatimn and couplinc xrz independent intermediate phenotypef, one og ahich is modulwted fy shsceptibility genes. A SNP in ZNF804A zppears to modulate LFC", "random_deletion": "integrative deficits that reflect genetic risk mechanisms These are mildly in siblings and genotype. suggests that altered activation and coupling independent intermediate phenotypes, one of which modulated by susceptibility genes. A SNP in ZNF804A appears to modulate PFC", "change_char_case": "integrative deficits that reFlect genetIc risK meChaNiSms fOr SZ. these deficits aRE milDly present in siblings anD normAl COntrOLs With tHe risk-aSSoCIAteD gEnOtyPe. tHiS suggEstS that alTered PFC acTivAtIon and coupliNG aRe independEnt Intermediate PheNotypeS, oNe oF Which Is mOdulaTed by sUSceptiBility genEs. a sNP in Znf804A appeaRS To ModuLate PFC", "whitespace_perturbation": "integrative deficits thatreflect ge netic  ri skme chan isms  for SZ. These defi cits are mildly presen t insi b ling s  a nd no rmal co n tr o l s w it hthe  r i sk -asso cia ted gen otype. Thi s s ug gests that a l te red PFC ac tiv ation and co upl ing ar eind e pende ntinter mediat e  pheno types, on eo f whic h  is mod u l at ed b y susceptibilityg en e s. A SNP in ZN F804Aap p ea r s  to  mo dulate PFC ", "underscore_trick": "integrative deficits_that reflect_genetic risk mechanisms for_SZ. These_deficits_are mildly_present_in siblings and_normal controls with_the risk-associated genotype. This_suggests that altered_PFC_activation and coupling are independent intermediate phenotypes, one of which is modulated by susceptibility_genes._A SNP_in_ZNF804A_appears to modulate PFC"}
{"text": " to cognition and interaction with aging, we confirm a role for the Parkinsons disease-associated FGF20 gene in brain structure and function during development and aging. Another study used healthy controls to explore the neural mechanism through which selective updating of information is stored in WM. A novel wm task was designed that parsed WM maintenance", "synonym_substitution": "to cognition and interaction with aging, we confirm a role for the Parkinsons disease - associated FGF20 gene in brain social organization and affair during development and aging. Another discipline use healthy controls to research the neural mechanism through which selective updating of information is stored in WM. A novel wm undertaking was designed that parsed WM sustenance", "butter_fingers": " to cognition and interactiun with aging, wg xonfirk a rome for tfe Parkinsons disease-associaved DGF20 gtue in brain structurd and funbtion durung vevelopment and efing. Another abudy bsxd healthy conttols to explmre the neural mdckanism through which selective updatyng of onvormation is sjored yn WJ. A novel wm task was designed thaf parsev WM maintenancr", "random_deletion": "to cognition and interaction with aging, we role the Parkinsons FGF20 gene in development aging. Another study healthy controls to the neural mechanism through which selective of information is stored in WM. A novel wm task was designed that WM maintenance", "change_char_case": " to cognition and interaction With aging, wE confIrm A roLe For tHe PaRkinsons diseasE-AssoCiated FGF20 gene in brain stRuctuRe ANd fuNCtIon duRing devELoPMEnt AnD aGinG. ANOtHer stUdy Used heaLthy controLs tO eXplore the neuRAl Mechanism tHroUgh which seleCtiVe updaTiNg oF InforMatIon is Stored IN WM. A noVel wm task WaS DesignED that paRSEd wM maIntenance", "whitespace_perturbation": " to cognition and interact ion with a ging,  we  co nf irma ro le for the Par k inso ns disease-associatedFGF20  g e ne i n  b rainstructu r ea n d f un ct ion  d u ri ng de vel opmentand aging.  An ot her study us e dhealthy co ntr ols to explo rethe ne ur alm echan ism  thro ugh wh i ch sel ective up da t ing of informa t i on  isstored in WM. A n o ve l  wm task was d esigne dt ha t par sed  WM mainte na nce", "underscore_trick": " to_cognition and_interaction with aging, we_confirm a_role_for the_Parkinsons_disease-associated FGF20 gene_in brain structure_and function during development_and aging. Another_study_used healthy controls to explore the neural mechanism through which selective updating of information_is_stored in_WM._A_novel wm task was designed_that parsed WM maintenance"}
{"text": "-length P. falciparum circumsporozoite protein prepared by Dr. Sanjay Singh at Gennova, India. Seven of these monoclonals have been produced in quantity, and we are working with extramural collaborators (Drs. Fidel Zavala and Chris Ockenhouse) to", "synonym_substitution": "-length P. falciparum circumsporozoite protein prepared by Dr. Sanjay Singh at Gennova, India. Seven of these monoclonals have been produced in quantity, and we are work with extramural collaborator (Drs. Fidel Zavala and Chris Ockenhouse) to", "butter_fingers": "-lenhth P. falciparum circumskorozoite protein preparxd by Dd. Sanjay Singh at Gennova, India. Sevei of thest monoclonals have ceen prodlced in qyantmty, and we are working wlch exfvamurcl collaborators (Drs. Fidel Zavala and Chsir Lckenhouse) to", "random_deletion": "-length P. falciparum circumsporozoite protein prepared by Singh Gennova, India. of these monoclonals and are working with collaborators (Drs. Fidel and Chris Ockenhouse) to", "change_char_case": "-length P. falciparum circumspOrozoite prOtein PreParEd By Dr. sanjAy Singh at GennoVA, IndIa. Seven of these monoclonAls haVe BEen pROdUced iN quantiTY, aND We aRe WoRkiNg WItH extrAmuRal collAborators (DRs. FIdEl Zavala and CHRiS OckenhousE) to", "whitespace_perturbation": "-length P. falciparum circ umsporozoi te pr ote inpr epar ed b y Dr. Sanjay S i nghat Gennova, India. Sev en of  t h esem on oclon als hav e  b e e n p ro du ced  i n  q uanti ty,  and we  are worki ngwi th extramura l  c ollaborato rs(Drs. FidelZav ala an dChr i s Ock enh ouse)  to", "underscore_trick": "-length P._falciparum circumsporozoite_protein prepared by Dr._Sanjay Singh_at_Gennova, India._Seven_of these monoclonals_have been produced_in quantity, and we_are working with_extramural_collaborators (Drs. Fidel Zavala and Chris Ockenhouse) to"}
{"text": " (osmotic swelling pressure and mechanical measurements). We also use dynamic methods e.g., neutron spin echo (NSE), dynamic light scattering (DLS) to observe the relaxation response as a function of length scale. Additionally, we developed a method to determine the distribution of counterions in the ionic atmosphere surrounding charged", "synonym_substitution": "(osmotic swelling pressure and mechanical measurements). We also practice active method acting e.g., neutron tailspin echo (NSE), dynamic lighter scattering (DLS) to observe the easiness response as a function of duration scale. Additionally, we developed a method acting to determine the distribution of counterions in the ionic atmosphere surrounding charged", "butter_fingers": " (oslotic swelling pressure xnd mechanical measurekents). Se also jse dynamic methods e.g., neutrln spin echo (NSE), dynamic lighg scatterpng (DLS) ti obwwrve the rxmaxatiok resllnse es a function on length scdle. Additionalny, wz developed a method to determine thq distrobktion of countgrionx in fhe ionic atmosphere surrounding cgarged", "random_deletion": "(osmotic swelling pressure and mechanical measurements). We dynamic e.g., neutron echo (NSE), dynamic the response as a of length scale. we developed a method to determine distribution of counterions in the ionic atmosphere surrounding charged", "change_char_case": " (osmotic swelling pressure anD mechanicaL measUreMenTs). we alSo usE dynamic methodS E.g., neUtron spin echo (NSE), dynamiC lighT sCAtteRInG (DLS) tO observE ThE RElaXaTiOn rEsPOnSe as a FunCtion of Length scalE. AdDiTionally, we deVElOped a methoD to Determine the DisTributIoN of COunteRioNs in tHe ioniC AtmospHere surroUnDIng chaRGed", "whitespace_perturbation": " (osmotic swelling pressur e and mech anica l m eas ur emen ts).  We also use d y nami c methods e.g., neutro n spi ne cho( NS E), d ynamicl ig h t  sc at te rin g( DL S) to  ob serve t he relaxat ion  r esponse as a fu nction oflen gth scale. A ddi tional ly , w e  deve lop ed amethod to det ermine th ed istrib u tion of c ou nter ions in the ionic at m osphere surrou ndingch a rg e d ", "underscore_trick": " (osmotic_swelling pressure_and mechanical measurements). We_also use_dynamic_methods e.g.,_neutron_spin echo (NSE),_dynamic light scattering_(DLS) to observe the_relaxation response as_a_function of length scale. Additionally, we developed a method to determine the distribution of_counterions_in the_ionic_atmosphere_surrounding charged"}
{"text": " mutants or by inhibiting FAK weakened the molecular clutch and switched FAs from load-and-fail compliance sensing to frictional slippage regime on compliant ECMs. In agreement with the clutch oscillation model, the load-and-fail regime could be rescued by further decreasing either substrate stiffness or myosin II contractility.", "synonym_substitution": "mutants or by inhibiting FAK weakened the molecular clutch and switch fetal alcohol syndrome from load - and - fail compliance sensing to frictional slippage regimen on compliant ECMs. In agreement with the clutch oscillation mannequin, the warhead - and - fail regime could be rescue by further decreasing either substrate severity or myosin II contractility.", "butter_fingers": " muhants or by inhibiting FXK weakened the molecunar clhtch and switched FAs from load-and-faml cimpliqnce sensing to frictiunal slipiage regine oi compliant ECMs. In agrecient aith vhe clutch osciklation mogel, the load-ang-fxip regime could be rescued by furthew decresslng either subftraue ftifrness or myosin II contractility.", "random_deletion": "mutants or by inhibiting FAK weakened the and FAs from compliance sensing to ECMs. agreement with the oscillation model, the regime could be rescued by further either substrate stiffness or myosin II contractility.", "change_char_case": " mutants or by inhibiting FAK wEakened the MolecUlaR clUtCh anD swiTched FAs from loAD-and-Fail compliance sensing tO fricTiONal sLIpPage rEgime on COmPLIanT EcMS. In AgREeMent wIth The clutCh oscillatIon MoDel, the load-anD-FaIl regime coUld Be rescued by fUrtHer decReAsiNG eithEr sUbstrAte stiFFness oR myosin II CoNTractiLIty.", "whitespace_perturbation": " mutants or by inhibitingFAK weaken ed th e m ole cu larclut ch and switche d  FAs  from load-and-fail co mplia nc e  sen s in g tofrictio n al s lip pa ge  re gi m eon co mpl iant EC Ms. In agr eem en t with the c l ut ch oscilla tio n model, the  lo ad-and -f ail regim e c ouldbe res c ued by  furtherde c reasin g  either s ub stra te stiffness or m y os i n II contracti lity.", "underscore_trick": " mutants_or by_inhibiting FAK weakened the_molecular clutch_and_switched FAs_from_load-and-fail compliance sensing_to frictional slippage_regime on compliant ECMs._In agreement with_the_clutch oscillation model, the load-and-fail regime could be rescued by further decreasing either substrate_stiffness_or myosin_II_contractility."}
{"text": "-2 by SIV Nef. Thus, our study identifies a novel mechanism of antagonism of rhesus BST-2 by Vpu that targets the same motif in BST-2 used by SIV Nef and might explain the expanded host-range observed for Vpu isolates in our previous study.", "synonym_substitution": "-2 by SIV Nef. Thus, our study identifies a novel mechanism of hostility of rhesus BST-2 by Vpu that target the like motif in BST-2 used by SIV Nef and might explain the expand host - range respect for Vpu isolates in our previous study.", "butter_fingers": "-2 by SIV Nef. Thus, our study ldentifies a novgl mechaiism of antagonksm of rhesus BST-2 by Vpu thav taegets the same motif in BST-2 used by DIV Nef qnd nught explamh the ew'andes hosc-renge observed fpr Vpu isonates in our psexilus study.", "random_deletion": "-2 by SIV Nef. Thus, our study novel of antagonism rhesus BST-2 by motif BST-2 used by Nef and might the expanded host-range observed for Vpu in our previous study.", "change_char_case": "-2 by SIV Nef. Thus, our study identIfies a noveL mechAniSm oF aNtagOnisM of rhesus BST-2 by vPu thAt targets the same motif iN BST-2 uSeD By SIv neF and mIght expLAiN THe eXpAnDed HoST-rAnge oBseRved for vpu isolateS in OuR previous stuDY.", "whitespace_perturbation": "-2 by SIV Nef. Thus, our s tudy ident ifies  anov el  mec hani sm of antagoni s m of  rhesus BST-2 by Vpu t hat t ar g etst he  same  motifi nB S T-2  u se d b yS IV  Nefand  mightexplain th e e xp anded host-r a ng e observed  fo r Vpu isolat esin our  p rev i ous s tud y.", "underscore_trick": "-2 by_SIV Nef._Thus, our study identifies_a novel_mechanism_of antagonism_of_rhesus BST-2 by_Vpu that targets_the same motif in_BST-2 used by_SIV_Nef and might explain the expanded host-range observed for Vpu isolates in our previous_study."}
{"text": ", at comparable Vif levels, CBF further enhanced A3G degradation suggesting that CBF facilitates A3G degradation by increasing the levels of Vif and by independently augmenting the ability of Vif to target A3G for degradation. We propose that CBF acts like a chaperone to stabilize Vif during", "synonym_substitution": ", at comparable Vif levels, CBF further enhanced A3 G degradation suggest that CBF facilitate A3 G degradation by increasing the grade of Vif and by independently augmenting the ability of Vif to target A3 G for abasement. We propose that CBF acts like a chaperone to brace Vif during", "butter_fingers": ", at comparable Vif levels, CNF further enhanewd A3G vegradafion sugeesting that CBF facilitates A3T degeadation by increasing the leveps of Vid anv by independently augmekcing fme abnlmty of Vif to tsrget A3G fmr degradation. Wd 'ropose that CBF acts like a chaperoge to syahilize Vif duryng", "random_deletion": ", at comparable Vif levels, CBF further degradation that CBF A3G degradation by and independently augmenting the of Vif to A3G for degradation. We propose that acts like a chaperone to stabilize Vif during", "change_char_case": ", at comparable Vif levels, CBF fUrther enhaNced A3g deGraDaTion SuggEsting that CBF fACiliTates A3G degradation by inCreasInG The lEVeLs of VIf and by INdEPEndEnTlY auGmENtIng thE abIlity of vif to targeT A3G FoR degradation. wE pRopose that cBF Acts like a chaPerOne to sTaBilIZe Vif DurIng", "whitespace_perturbation": ", at comparable Vif levels , CBF furt her e nha nce dA3Gdegr adation sugges t ingthat CBF facilitates A 3G de gr a dati o nby in creasin g  t h e  le ve ls  of  V i fand b y i ndepend ently augm ent in g the abilit y  o f Vif to t arg et A3G for d egr adatio n.  We propo sethatCBF ac t s like  a chaper on e  to st a bilizeV i fduri ng", "underscore_trick": ", at_comparable Vif_levels, CBF further enhanced_A3G degradation_suggesting_that CBF_facilitates_A3G degradation by_increasing the levels_of Vif and by_independently augmenting the_ability_of Vif to target A3G for degradation. We propose that CBF acts like a_chaperone_to stabilize_Vif_during"}
{"text": " multiple strains is to investigate genetic diversity suggested by observed phenotypic and/or genetic diversity Our current work aims to understand the social mechanisms underlying the dissemination of family risk information and cooperative adaptation to shared risk. We examine these processes across several different disease contexts, representing highly penetrant, genetic disorders as well as more common, complex diseases", "synonym_substitution": "multiple strains is to investigate genetic diversity suggested by ascertained phenotypic and/or familial diversity Our current work drive to sympathize the social mechanisms underlying the dissemination of class risk information and concerted adaptation to shared risk. We test these processes across several unlike disease contexts, representing highly penetrant, familial disorders as well as more coarse, complex diseases", "butter_fingers": " muptiple strains is to invtstigate genetic buversivy suggssted by observed phenotypic and/or gxnetuc dicersity Our current wofk aims tl undersrand rhe social mechanisms unscrlyiug the disseminajion of faminy risk informdtkou and cooperative adaptation to sharqd risk. Wf examine thesg probefses across several different disease dontextv, representinb highly penetrant, genetic dislrders as well as lore common, com[oex diseases", "random_deletion": "multiple strains is to investigate genetic diversity observed and/or genetic Our current work mechanisms the dissemination of risk information and adaptation to shared risk. We examine processes across several different disease contexts, representing highly penetrant, genetic disorders as well more common, complex diseases", "change_char_case": " multiple strains is to investIgate genetIc divErsIty SuGgesTed bY observed phenoTYpic And/or genetic diversity OUr curReNT worK AiMs to uNderstaND tHE SocIaL mEchAnISmS undeRlyIng the dIsseminatiOn oF fAmily risk infORmAtion and coOpeRative adaptaTioN to shaReD riSK. We exAmiNe theSe procESses acRoss severAl DIffereNT diseasE COnTextS, representing highLY pENetrant, genetic DisordErS As WELl aS moRe common, coMpLex diSEases", "whitespace_perturbation": " multiple strains is to in vestigategenet icdiv er sity  sug gested by obse r vedphenotypic and/or gene tic d iv e rsit y  O ur cu rrent w o rk a ims  t ound er s ta nd th e s ocial m echanismsund er lying the di s se mination o f f amily risk i nfo rmatio nand coope rat ive a daptat i on toshared ri sk .  We ex a mine th e s eproc esses across seve r al different dise ase co nt e xt s ,  re pre senting hi gh ly pe n etrant, ge n e t icd isorders as w ell as more com mon, c om ple x  disea ses", "underscore_trick": " multiple_strains is_to investigate genetic diversity_suggested by_observed_phenotypic and/or_genetic_diversity Our current_work aims to_understand the social mechanisms_underlying the dissemination_of_family risk information and cooperative adaptation to shared risk. We examine these processes across_several_different disease_contexts,_representing_highly penetrant, genetic disorders as_well as more common, complex_diseases"}
{"text": " we showed that both the recycling cell surface receptor and the nascent receptor in transit to the plasma membrane were susceptible to intra-cellular retention and degradation by HIV-1 Nef (J Cell Biology, 163, 1281, 2003 and J Biol Chem. 280, 7413, 2005). Nef is thought to mediate", "synonym_substitution": "we showed that both the recycling cell surface receptor and the nascent sense organ in passage to the plasma membrane were susceptible to intra - cellular retention and degradation by HIV-1 Nef (J Cell Biology, 163, 1281, 2003 and J Biol Chem. 280, 7413, 2005). Nef is think to intercede", "butter_fingers": " we showed that both the regycling cell suryqce rereptor znd the vascent receptor in transit vo tye plqsma membrane were suszeptible no intra-cwlluoqr retention and dcyradaflon bv IIV-1 Nef (J Cell Niology, 163, 1281, 2003 dnd J Biol Chek. 280, 7413, 2005). Nef is thought to mediate", "random_deletion": "we showed that both the recycling cell and nascent receptor transit to the intra-cellular and degradation by Nef (J Cell 163, 1281, 2003 and J Biol 280, 7413, 2005). Nef is thought to mediate", "change_char_case": " we showed that both the recyclIng cell surFace rEcePtoR aNd thE nasCent receptor in TRansIt to the plasma membrane wEre suScEPtibLE tO intrA-cellulAR rETEntIoN aNd dEgRAdAtion By HiV-1 Nef (J CEll Biology, 163, 1281, 2003 And j BIol Chem. 280, 7413, 2005). Nef is THoUght to mediAte", "whitespace_perturbation": " we showed that both the r ecycling c ell s urf ace  r ecep torand the nascen t  rec eptor in transit to th e pla sm a  mem b ra ne we re susc e pt i b leto  i ntr a- c el lular  re tention  and degra dat io n by HIV-1 N e f(J Cell Bi olo gy, 163, 128 1,2003 a nd  JB iol C hem . 280 , 7413 ,  2005) . Nef isth o ught t o  mediat e ", "underscore_trick": " we_showed that_both the recycling cell_surface receptor_and_the nascent_receptor_in transit to_the plasma membrane_were susceptible to intra-cellular_retention and degradation_by_HIV-1 Nef (J Cell Biology, 163, 1281, 2003 and J Biol Chem. 280, 7413,_2005)._Nef is_thought_to_mediate"}
{"text": " (hu-liver-chimeric) mice. CAdA and CdG were also potent against a highly entecavir (ETV)-resistant HBV variant containing three critical amino acid substitutions: L180M, S202G, and M204V (HBVL180M/S202G/ M", "synonym_substitution": "(hu - liver - chimeric) mice. CAdA and CdG were also potent against a highly entecavir (ETV)-resistant HBV variant containing three critical amino acid substitution: L180 M, S202 G, and M204V (HBVL180M / S202G/ M", "butter_fingers": " (hu-piver-chimeric) mice. CAdA xnd CdG were also poteit agaihst a hiehly entecavir (ETV)-resistant IBV cariabt containing three crktical ampno acid wubsuitutions: L180M, S202G, ais M204V (HBYJ180M/S202G/ L", "random_deletion": "(hu-liver-chimeric) mice. CAdA and CdG were also a entecavir (ETV)-resistant variant containing three S202G, M204V (HBVL180M/S202G/ M", "change_char_case": " (hu-liver-chimeric) mice. CAdA anD CdG were alSo potEnt AgaInSt a hIghlY entecavir (ETV)-rESistAnt HBV variant containinG threE cRIticAL aMino aCid subsTItUTIonS: L180m, S202g, anD M204v (hBvL180M/S202G/ m", "whitespace_perturbation": " (hu-liver-chimeric) mice.  CAdA andCdG w ere  al so  pot entagainst a high l y en tecavir (ETV)-resistan t HBV  v a rian t  c ontai ning th r ee c rit ic al  am in o  a cid s ubs titutio ns: L180M,  S2 02 G, and M204V (H BVL180M/S2 02G / M", "underscore_trick": " (hu-liver-chimeric)_mice. CAdA_and CdG were also_potent against_a_highly entecavir_(ETV)-resistant_HBV variant containing_three critical amino_acid substitutions: L180M, S202G,_and M204V (HBVL180M/S202G/_M"}
{"text": "izes the plasma membrane. This allowed us to determine the fundamental organization of the exocytic membrane system and how specific molecular components responsible for vesicle trafficking and fusion assemble together and function. Specifically, we have been using two-color TIRF microscopy and high-throughput image analysis to detect and characterize over 80 different proteins that have", "synonym_substitution": "izes the plasma membrane. This allowed us to determine the fundamental organization of the exocytic membrane arrangement and how specific molecular component responsible for vesicle trafficking and fusion assemble in concert and function. Specifically, we have been using two - color TIRF microscopy and eminent - throughput image analysis to detect and qualify over 80 unlike proteins that have", "butter_fingers": "ized the plasma membrane. Thls allowed us to determmne the fundamevtal organization of the exorytix memvrane system and how soecific mllecular comkonents responsible for vcficls trayfmcking and fusipn assembla together and fjnetion. Specifically, we have been usind two-cokog TIRF microscjpy sgd hjgh-throughput image analysis to defect anv characterize pver 80 different proteins tjat jave", "random_deletion": "izes the plasma membrane. This allowed us the organization of exocytic membrane system responsible vesicle trafficking and assemble together and Specifically, we have been using two-color microscopy and high-throughput image analysis to detect and characterize over 80 different proteins have", "change_char_case": "izes the plasma membrane. This Allowed us tO deteRmiNe tHe FundAmenTal organizatioN Of thE exocytic membrane systeM and hOw SPeciFIc MolecUlar comPOnENTs rEsPoNsiBlE FoR vesiCle TrafficKing and fusIon AsSemble togethER aNd function. speCifically, we hAve Been usInG twO-Color tIRf micrOscopy ANd high-ThroughpuT iMAge anaLYsis to dETEcT and Characterize over 80 dIFfERent proteins thAt have", "whitespace_perturbation": "izes the plasma membrane.This allow ed us  to  de te rmin e th e fundamentalo rgan ization of the exocyti c mem br a ne s y st em an d how s p ec i f icmo le cul ar co mpone nts  respon sible forves ic le trafficki n gand fusion  as semble toget her  and f un cti o n. Sp eci fical ly, we have b een using  t w o-colo r  TIRF m i c ro scop y and high-throug h pu t  image analysi s to d et e ct a ndcha racterizeov er 80 differe n tp r o tei n s that have", "underscore_trick": "izes the_plasma membrane._This allowed us to_determine the_fundamental_organization of_the_exocytic membrane system_and how specific_molecular components responsible for_vesicle trafficking and_fusion_assemble together and function. Specifically, we have been using two-color TIRF microscopy and high-throughput_image_analysis to_detect_and_characterize over 80 different proteins_that have"}
{"text": " patients with premature reactivation of hypothalamic GnRH secretion, resulting in idiopathic central precocious puberty (CPP). There is evidence that familial cases account for anywhere from 20-45% of CPP, with most studies describing autosomal dominant inheritance patterns. Far less is known about the molecular basis of CPP, and candidate", "synonym_substitution": "patients with premature reactivation of hypothalamic GnRH secretion, resulting in idiopathic central precocious puberty (CPP). There be evidence that familial case account for anywhere from 20 - 45% of CPP, with most studies describing autosomal prevailing inheritance patterns. Far less is known about the molecular basis of CPP, and campaigner", "butter_fingers": " pahients with premature rexctivation of hipithalakic GnDH secregion, resulting in idiopathic cwntrao precocious puberty (COP). There ps evidenxe tiat familial casxa accoukc for wnywkece from 20-45% of CPP, with most studies descrhbkny autosomal dominant inheritance pateerns. Fsr less is known abolt the molecular basis of CPP, and candidzte", "random_deletion": "patients with premature reactivation of hypothalamic GnRH in central precocious (CPP). There is for from 20-45% of with most studies autosomal dominant inheritance patterns. Far less known about the molecular basis of CPP, and candidate", "change_char_case": " patients with premature reacTivation of HypotHalAmiC GNRH sEcreTion, resulting iN IdioPathic central precociouS pubeRtY (cPP). THErE is evIdence tHAt FAMilIaL cAseS aCCoUnt foR anYwhere fRom 20-45% of CPP, wiTh mOsT studies descRIbIng autosomAl dOminant inherItaNce patTeRns. fAr lesS is Known About tHE molecUlar basis Of cpP, and cANdidate", "whitespace_perturbation": " patients with premature r eactivatio n ofhyp oth al amic  GnR H secretion, r e sult ing in idiopathic cent ral p re c ocio u spuber ty (CPP ) .T h ere  i sevi de n ce  that  fa milialcases acco unt  f or anywheref ro m 20-45% o f C PP, with mos t s tudies  d esc r ibing  au tosom al dom i nant i nheritanc ep attern s . Far l e s sis k nown about the mo l ec u lar basis of C PP, an dc an d i dat e", "underscore_trick": " patients_with premature_reactivation of hypothalamic GnRH_secretion, resulting_in_idiopathic central_precocious_puberty (CPP). There_is evidence that_familial cases account for_anywhere from 20-45%_of_CPP, with most studies describing autosomal dominant inheritance patterns. Far less is known about_the_molecular basis_of_CPP,_and candidate"}
{"text": "Fc substrate. In addition, N-TACE18-54 inhibited constitutive TNFR2 shedding from a human monocytic cell line by 42%. A 19-amino acid, leucine-rich domain, corresponding to TACE amino acids 30 to 48, demonstrated partial inhibitory activity. Thus, we identified a sub-domain", "synonym_substitution": "Fc substrate. In addition, N - TACE18 - 54 inhibited constitutive TNFR2 shedding from a human monocytic cellular telephone credit line by 42% . A 19 - amino acid, leucine - rich domain, correspond to TACE amino acid 30 to 48, demonstrated partial inhibitory activeness. therefore, we identified a sub - domain", "butter_fingers": "Fc dubstrate. In addition, N-TXCE18-54 inhibited constituvive TNRR2 sheddkng from a human monocytic cxll oine vy 42%. A 19-amino acid, leucive-rich dolain, coreespibding to TEDE amino acida 30 to 48, demonstrated kartial inhititory activitf. Ghbs, we identified a sub-domain", "random_deletion": "Fc substrate. In addition, N-TACE18-54 inhibited constitutive from human monocytic line by 42%. corresponding TACE amino acids to 48, demonstrated inhibitory activity. Thus, we identified a", "change_char_case": "Fc substrate. In addition, N-TACe18-54 inhibited ConstItuTivE TnFR2 sHeddIng from a human mONocyTic cell line by 42%. A 19-amino aciD, leucInE-Rich DOmAin, coRresponDInG TO TAcE AmIno AcIDs 30 To 48, demOnsTrated pArtial inhiBitOrY activity. ThuS, We Identified A suB-domain", "whitespace_perturbation": "Fc substrate. In addition,  N-TACE18- 54 in hib ite dcons titu tive TNFR2 she d ding  from a human monocyti c cel ll ineb y42%.A 19-am i no a cid ,le uci ne - ri ch do mai n, corr espondingtoTA CE amino aci d s30 to 48,dem onstrated pa rti al inh ib ito r y act ivi ty. T hus, w e  ident ified a s ub - domain ", "underscore_trick": "Fc substrate._In addition,_N-TACE18-54 inhibited constitutive TNFR2_shedding from_a_human monocytic_cell_line by 42%._A 19-amino acid,_leucine-rich domain, corresponding to_TACE amino acids_30_to 48, demonstrated partial inhibitory activity. Thus, we identified a sub-domain"}
{"text": " in MC3R(hDM/hDM) mice and MC3R(hDM/hDM) human subjects. MC3R(hDM/hDM) bone- and adipose tissue-derived mesenchymal stem cells (MSCs) differentiated into adipocytes that accumulated more triglyceride than MC3R(hWT/", "synonym_substitution": "in MC3R(hDM / hDM) mice and MC3R(hDM / hDM) human subjects. MC3R(hDM / hDM) bone- and adipose tissue - derived mesenchymal stem cell (MSCs) differentiate into adipocytes that accumulated more triglyceride than MC3R(hWT/", "butter_fingers": " in MC3R(hDM/hDM) mice and MC3R(hAM/hDM) human sublwcts. MR3R(hDM/hDJ) bone- avd adipose tissue-derived mesxnchtmal wtem cells (MSCs) differdntiated pnto adipicytts that accumulatxs more bxiglydcride vhan MC3R(hWT/", "random_deletion": "in MC3R(hDM/hDM) mice and MC3R(hDM/hDM) human subjects. and tissue-derived mesenchymal cells (MSCs) differentiated triglyceride MC3R(hWT/", "change_char_case": " in MC3R(hDM/hDM) mice and MC3R(hDM/hdM) human subJects. mC3R(HDM/HDm) bonE- and Adipose tissue-dERiveD mesenchymal stem cells (MsCs) diFfERentIAtEd intO adipocYTeS THat AcCuMulAtED mOre trIglYceride Than MC3R(hWT/", "whitespace_perturbation": " in MC3R(hDM/hDM) mice and  MC3R(hDM/ hDM)hum ansu bjec ts.MC3R(hDM/hDM)b one-  and adipose tissue-de rived  m e senc h ym al st em cell s  ( M S Cs)  d if fer en t ia ted i nto  adipoc ytes thatacc um ulated moret ri glyceridetha n MC3R(hWT/", "underscore_trick": " in_MC3R(hDM/hDM) mice_and MC3R(hDM/hDM) human subjects._MC3R(hDM/hDM) bone-_and_adipose tissue-derived_mesenchymal_stem cells (MSCs)_differentiated into adipocytes_that accumulated more triglyceride_than MC3R(hWT/"}
{"text": " the chemotactic function of neutrophils differentiated from these progenitor cells in vitro. Transplantation of FV-hCD18-transduced LAD-1 HSPCs into immuno-deficient (NSG) mice resulted in high-level, clinically relevant gene marking levels in vivo. The average percentages of human cells expressing CD18", "synonym_substitution": "the chemotactic function of neutrophils differentiated from these progenitor cells in vitro. Transplantation of FV - hCD18 - transduce LAD-1 HSPCs into immuno - insufficient (NSG) mouse resulted in eminent - grade, clinically relevant gene marking levels in vivo. The median share of human cells express CD18", "butter_fingers": " thf chemotactic function on neutrophils diyderentmated fdom thesd progenitor cells in vitro. Vranwplanuction of FV-hCD18-transdjced LAD-1 JSPCs inro innuno-deficixht (NSG) mice rsdultzd in high-level, glinically selevant gene kafknng levels in vivo. The average percegtages pf human cells evprexfing BD18", "random_deletion": "the chemotactic function of neutrophils differentiated from cells vitro. Transplantation FV-hCD18-transduced LAD-1 HSPCs in clinically relevant gene levels in vivo. average percentages of human cells expressing", "change_char_case": " the chemotactic function of nEutrophils DiffeRenTiaTeD froM theSe progenitor ceLLs in Vitro. Transplantation of fV-hCD18-TrANsduCEd lAD-1 HSpCs into IMmUNO-deFiCiEnt (nSg) MiCe resUltEd in higH-level, clinIcaLlY relevant genE MaRking levelS in Vivo. The averaGe pErcentAgEs oF Human CelLs expRessinG cD18", "whitespace_perturbation": " the chemotactic functionof neutrop hilsdif fer en tiat ed f rom these prog e nito r cells in vitro. Tran splan ta t iono fFV-hC D18-tra n sd u c edLA D- 1 H SP C sintoimm uno-def icient (NS G)mi ce resultedi nhigh-level , c linically re lev ant ge ne  ma r kinglev els i n vivo .  The a verage pe rc e ntages of huma n ce llsexpressing CD18", "underscore_trick": " the_chemotactic function_of neutrophils differentiated from_these progenitor_cells_in vitro._Transplantation_of FV-hCD18-transduced LAD-1_HSPCs into immuno-deficient_(NSG) mice resulted in_high-level, clinically relevant_gene_marking levels in vivo. The average percentages of human cells expressing CD18"}
{"text": " [unreadable] In addition to removing the PPT primer from the plus strand, RNase H is known to remove the primer from the 5? end of the minus strand DNA. Tf1 uses a unique mechanism of self-priming to initiate reverse transcription. Instead of using a tRNA, Tf1 primes minus strand", "synonym_substitution": "[ unreadable ] In addition to removing the PPT primer from the plus strand, RNase H is know to absent the primer from the 5? end of the minus strand DNA. Tf1 use a unique mechanism of self - priming to originate reverse transcription. alternatively of using a tRNA, Tf1 primes minus strand", "butter_fingers": " [ungeadable] In addition to vemoving the PPT primer from fhe plus strand, RNase H is known to cemoce tht primer from the 5? dnd of thv minus srranv DNA. Tf1 uses a nhique mcehanial of welf-priming to initiate severse transcsiotnon. Instead of using a tRNA, Tf1 primef minus shrand", "random_deletion": "[unreadable] In addition to removing the PPT the strand, RNase is known to 5? of the minus DNA. Tf1 uses unique mechanism of self-priming to initiate transcription. Instead of using a tRNA, Tf1 primes minus strand", "change_char_case": " [unreadable] In addition to remOving the PPt primEr fRom ThE pluS strAnd, RNase H is knoWN to rEmove the primer from the 5? eNd of tHe MInus STrAnd DNa. Tf1 uses A UnIQUe mEcHaNisM oF SeLf-priMinG to initIate reversE trAnScription. InsTEaD of using a trNA, tf1 primes minuS stRand", "whitespace_perturbation": " [unreadable] In additionto removin g the  PP T p ri merfrom  the plus stra n d, R Nase H is known to rem ove t he prim e rfromthe 5?e nd o f t he  m inu ss tr and D NA.  Tf1 us es a uniqu e m ec hanism of se l f- priming to  in itiate rever setransc ri pti o n. In ste ad of  using a tRNA , Tf1 pri me s  minus strand", "underscore_trick": " [unreadable]_In addition_to removing the PPT_primer from_the_plus strand,_RNase_H is known_to remove the_primer from the 5?_end of the_minus_strand DNA. Tf1 uses a unique mechanism of self-priming to initiate reverse transcription. Instead_of_using a_tRNA,_Tf1_primes minus strand"}
{"text": " from degradation in lysosomes. In the absence of EpCAM, whole cell levels of claudin-7 and claudin-1 decrease dramatically but remaining claudin-7 and claudin-1 becomes tight junction-associated. This results in increased tight junction avidity and increased trans-epithelial electrical resistance", "synonym_substitution": "from degradation in lysosomes. In the absence of EpCAM, whole cell degree of claudin-7 and claudin-1 decrease dramatically but remain claudin-7 and claudin-1 becomes tight junction - consort. This results in increased close articulation avidity and increased trans - epithelial electrical resistance", "butter_fingers": " frlm degradation in lysosooes. In the abseuxe of XpCAM, wgole celu levels of claudin-7 and clauvin-1 eecreqse dramatically but rdmaining blaudin-7 abd coqudin-1 becomes tighb jundbion-avwociated. This tesults in itcreased tight jjnetion avidity and increased trans-epiehelial epectrical resiftanbe", "random_deletion": "from degradation in lysosomes. In the absence whole levels of and claudin-1 decrease claudin-1 tight junction-associated. This in increased tight avidity and increased trans-epithelial electrical resistance", "change_char_case": " from degradation in lysosomeS. In the abseNce of epCaM, wHoLe ceLl leVels of claudin-7 aND claUdin-1 decrease dramaticalLy but ReMAiniNG cLaudiN-7 and claUDiN-1 BEcoMeS tIghT jUNcTion-aSsoCiated. THis results In iNcReased tight jUNcTion aviditY anD increased trAns-EpitheLiAl eLEctriCal ResisTance", "whitespace_perturbation": " from degradation in lysos omes. In t he ab sen ceof  EpC AM,whole cell lev e ls o f claudin-7 and claudi n-1 d ec r ease dr amati cally b u tr e mai ni ng  cl au d in -7 an d c laudin- 1 becomestig ht  junction-as s oc iated. Thi s r esults in in cre ased t ig htj uncti onavidi ty and increa sed trans -e p itheli a l elect r i ca l re sistance", "underscore_trick": " from_degradation in_lysosomes. In the absence_of EpCAM,_whole_cell levels_of_claudin-7 and claudin-1_decrease dramatically but_remaining claudin-7 and claudin-1_becomes tight junction-associated._This_results in increased tight junction avidity and increased trans-epithelial electrical resistance"}
{"text": " However, a small population of enteroendocrine cells migrates downward to the bottom of the crypt. Enteroendocrine cells are comprised of subsets, whose differentiation is determined by specific transcription factors that regulate both the specific co-expression of hormones and their location within the crypt-villus axis. The differentiation signaling pathways", "synonym_substitution": "However, a small population of enteroendocrine cells migrates downward to the bottomland of the crypt. Enteroendocrine cell are comprised of subsets, whose differentiation is determine by specific transcription factors that baffle both the specific colorado - expression of hormone and their placement within the crypt - villus axis. The specialization signaling pathways", "butter_fingers": " Hoaever, a small population of enteroendoctibe celns migdates dodnward to the bottom of the rrypr. Enttgoendocrine cells are comprisef of subwets, qhose diffxdentiatljn ia detzrnined by specinic transcrhption factors tfac regulate both the specific co-exprefsion og jormones and treir jocafpok within the crypt-villus axis. Ths diffegentiation signalong pathways", "random_deletion": "However, a small population of enteroendocrine cells to bottom of crypt. Enteroendocrine cells differentiation determined by specific factors that regulate the specific co-expression of hormones and location within the crypt-villus axis. The differentiation signaling pathways", "change_char_case": " However, a small population of EnteroendoCrine CelLs mIgRateS dowNward to the bottOM of tHe crypt. Enteroendocrine Cells ArE CompRIsEd of sUbsets, wHOsE DIffErEnTiaTiON iS deteRmiNed by spEcific tranScrIpTion factors tHAt Regulate boTh tHe specific co-ExpRessioN oF hoRMones And Their LocatiON withiN the crypt-ViLLus axiS. the diffEREnTiatIon signaling pathwAYs", "whitespace_perturbation": " However, a small populati on of ente roend ocr ine  c ells  mig rates downward to t he bottom of the crypt . Ent er o endo c ri ne ce lls are co m p ris ed  o f s ub s et s, wh ose  differ entiationisde termined bys pe cific tran scr iption facto rsthat r eg ula t e bot h t he sp ecific co-exp ression o fh ormone s  and th e i rloca tion within the c r yp t -villus axis.The di ff e re n t iat ion  signaling  p athwa y s", "underscore_trick": " However,_a small_population of enteroendocrine cells_migrates downward_to_the bottom_of_the crypt. Enteroendocrine_cells are comprised_of subsets, whose differentiation_is determined by_specific_transcription factors that regulate both the specific co-expression of hormones and their location within_the_crypt-villus axis._The_differentiation_signaling pathways"}
{"text": " central question is whether the kind of arousal measured in our assays reflects the global state of excitability in the central nervous system or is subserved by more restricted circuitry. To answer this question we use the GAL4/UAS system, which permits expression of the channel under the control of various promoters. We previously", "synonym_substitution": "central question is whether the kind of arousal measured in our assay reflect the global state of excitability in the central aflutter system or is subserved by more restricted circuitry. To suffice this question we use the GAL4 / UAS system, which permit expression of the channel under the command of various promoters. We previously", "butter_fingers": " cejtral question is whethev the kind of arousal mxasured in our xssays reflects the global svate of ezcitability in the cengral nervlus systwm oc is subserved bb more rcftridbed cnrruitry. To answet this questhon we use the GXL4/BAS system, which permits expression jf the vhwnnel under thg conuroj of navious promoters. We previously", "random_deletion": "central question is whether the kind of in assays reflects global state of system is subserved by restricted circuitry. To this question we use the GAL4/UAS which permits expression of the channel under the control of various promoters. We", "change_char_case": " central question is whether tHe kind of arOusal MeaSurEd In ouR assAys reflects the GLobaL state of excitability in The ceNtRAl neRVoUs sysTem or is SUbSERveD bY mOre ReSTrIcted CirCuitry. TO answer thiS quEsTion we use the gaL4/uAS system, wHicH permits exprEssIon of tHe ChaNNel unDer The coNtrol oF VariouS promoterS. WE PrevioUSly", "whitespace_perturbation": " central question is wheth er the kin d ofaro usa lmeas ured  in our assays refl ects the global stateof ex ci t abil i ty  in t he cent r al n erv ou ssys te m  o r issub servedby more re str ic ted circuitr y .To answerthi s question w e u se the  G AL4 / UAS s yst em, w hich p e rmitsexpressio no f thec hannelu n de r th e control of vari o us promoters. Weprevio us l y", "underscore_trick": " central_question is_whether the kind of_arousal measured_in_our assays_reflects_the global state_of excitability in_the central nervous system_or is subserved_by_more restricted circuitry. To answer this question we use the GAL4/UAS system, which permits_expression_of the_channel_under_the control of various promoters._We previously"}
{"text": " acid sequence was deduced from a RT-PCR product generated from NCI-H292 human pulmonary epithelial cell line total RNA and primers spanning the full-length TACE coding region. In an in vitro model assay system, N-TACE18-54 attenuated TACE-catalyzed cleavage of a TNFR2:", "synonym_substitution": "acid sequence was deduced from a RT - PCR product generated from NCI - H292 human pneumonic epithelial cellular telephone occupation total RNA and primers cross the full - distance TACE coding region. In an in vitro exemplar assay system, N - TACE18 - 54 attenuated TACE - catalyzed cleavage of a TNFR2:", "butter_fingers": " acld sequence was deduced nrom a RT-PCR probyct geierated from NCK-H292 human pulmonary epitheliap xell oine total RNA and prioers spanjing the fulo-oength TACX coding regioh. In cn in vitro modek assay syvtem, N-TACE18-54 attanjaced TACE-catalyzed cleavage of a TNFR2:", "random_deletion": "acid sequence was deduced from a RT-PCR from human pulmonary cell line total full-length coding region. In in vitro model system, N-TACE18-54 attenuated TACE-catalyzed cleavage of TNFR2:", "change_char_case": " acid sequence was deduced froM a RT-PCR proDuct gEneRatEd From nCI-H292 Human pulmonary EPithElial cell line total RNA aNd priMeRS spaNNiNg the Full-lenGTh tacE cOdInG reGiON. IN an in VitRo model Assay systeM, N-TaCe18-54 attenuated TacE-Catalyzed cLeaVage of a TNFR2:", "whitespace_perturbation": " acid sequence was deduced  from a RT -PCRpro duc tgene rate d from NCI-H29 2  hum an pulmonary epithelia l cel ll inet ot al RN A and p r im e r s s pa nn ing  t h efull- len gth TAC E coding r egi on . In an in v i tr o model as say  system, N-T ACE 18-54at ten u atedTAC E-cat alyzed cleava ge of a T NF R 2:", "underscore_trick": " acid_sequence was_deduced from a RT-PCR_product generated_from_NCI-H292 human_pulmonary_epithelial cell line_total RNA and_primers spanning the full-length_TACE coding region._In_an in vitro model assay system, N-TACE18-54 attenuated TACE-catalyzed cleavage of a TNFR2:"}
{"text": "atable foods can help children avoid weight gain. Given the rapid increase in the prevalence of obesity, the development of treatments for obesity is urgently needed (16-18). In clinical protocols, we have studied pharmacotherapeutic approaches to the control of body weight (19-21). Metformin 1000 mg BID was studied in 100", "synonym_substitution": "atable foods can help children avoid system of weights amplification. Given the rapid increase in the prevalence of fleshiness, the development of treatments for obesity is urgently necessitate (16 - 18). In clinical protocols, we have studied pharmacotherapeutic approach to the control of body weight unit (19 - 21). Metformin 1000 mg BID was studied in 100", "butter_fingers": "atahle foods can help childven avoid weight gain. Gmven ths rapid kncrease in the prevalence oh obwsity, the development of trdatments vor obesuty ms urgently needxs (16-18). In clinicam procorols, we have stodied pharmawotherapeutic dporlaches to the control of body weighe (19-21). Metfprlin 1000 mg BID waf stldyed jn 100", "random_deletion": "atable foods can help children avoid weight the increase in prevalence of obesity, obesity urgently needed (16-18). clinical protocols, we studied pharmacotherapeutic approaches to the control body weight (19-21). Metformin 1000 mg BID was studied in 100", "change_char_case": "atable foods can help childreN avoid weigHt gaiN. GiVen ThE rapId inCrease in the preVAlenCe of obesity, the developmEnt of TrEAtmeNTs For obEsity is URgENTly NeEdEd (16-18). IN cLInIcal pRotOcols, we Have studieD phArMacotherapeuTIc Approaches To tHe control of bOdy Weight (19-21). meTfoRMin 1000 mg bID Was stUdied iN 100", "whitespace_perturbation": "atable foods can help chil dren avoid  weig htgai n.  Giv en t he rapid incre a se i n the prevalence of ob esity ,t he d e ve lopme nt of t r ea t m ent sfo r o be s it y isurg ently n eeded (16- 18) .In clinicalp ro tocols, we  ha ve studied p har macoth er ape u tic a ppr oache s to t h e cont rol of bo dy weight (19-21) . Me tfor min 1000 mg BID w a ss tudied in 100", "underscore_trick": "atable foods_can help_children avoid weight gain._Given the_rapid_increase in_the_prevalence of obesity,_the development of_treatments for obesity is_urgently needed (16-18)._In_clinical protocols, we have studied pharmacotherapeutic approaches to the control of body weight (19-21)._Metformin_1000 mg_BID_was_studied in 100"}
{"text": " merozoite proteins do not diminish during the dry season with little malaria transmission. We are continuing to follow the antibody profiles over several transmission seasons using both ELISA and GIA as readouts and are also conducting more in depth studies of the antibodies themselves. In addition, we have developed a flow cytometry assay to profile the", "synonym_substitution": "merozoite proteins do not diminish during the dry season with little malaria transmission. We are continue to be the antibody profiles over several transmission season using both ELISA and GIA as readouts and are besides conducting more in depth studies of the antibody themselves. In accession, we have developed a menstruation cytometry assay to profile the", "butter_fingers": " megozoite proteins do not aiminish during the drb seasoh with lkttle malaria transmission. Wx arw conupnuing to follow the xntibody irofiles iver weveral trehsmission seaalns bsmng both ELISA snd GIA as readouts and drd clso conducting more in depth studief of thr wntibodies theiselnef. In addition, we have developed a flow cytomeury assay to profike the", "random_deletion": "merozoite proteins do not diminish during the with malaria transmission. are continuing to several seasons using both and GIA as and are also conducting more in studies of the antibodies themselves. In addition, we have developed a flow cytometry to profile the", "change_char_case": " merozoite proteins do not dimInish durinG the dRy sEasOn With LittLe malaria transMIssiOn. We are continuing to folLow thE aNTiboDY pRofilEs over sEVeRAL trAnSmIssIoN SeAsons UsiNg both ElISA and GIA As rEaDouts and are aLSo Conducting MorE in depth studIes Of the aNtIboDIes thEmsElves. in addiTIon, we hAve develoPeD A flow cYTometry ASSaY to pRofile the", "whitespace_perturbation": " merozoite proteins do not  diminishdurin g t hedr y se ason  with little m a lari a transmission. We are  cont in u ingt ofollo w the a n ti b o dypr of ile so ve r sev era l trans mission se aso ns  using bothE LI SA and GIA  as  readouts an d a re als ocon d uctin g m ore i n dept h  studi es of the  a n tibodi e s thems e l ve s. I n addition, we ha v ed eveloped a flo w cyto me t ry a ssa y t o profileth e", "underscore_trick": " merozoite_proteins do_not diminish during the_dry season_with_little malaria_transmission._We are continuing_to follow the_antibody profiles over several_transmission seasons using_both_ELISA and GIA as readouts and are also conducting more in depth studies of_the_antibodies themselves._In_addition,_we have developed a flow_cytometry assay to profile the"}
{"text": " have attempted to elucidate the role of the above mentioned factors in disease pathogenesis by comparing the plasma levels of the various markers in four groups of individuals: chronic pathology individuals with or without active filarial infection, asymptomatic, filarial infected individuals and uninfected, endemic normal individuals. We show that circulating levels of LPS, acute phase", "synonym_substitution": "have attempted to elucidate the role of the above mentioned divisor in disease pathogenesis by compare the plasma levels of the various markers in four group of individuals: chronic pathology individuals with or without active filarial contagion, asymptomatic, filarial infected individuals and uninfected, endemic normal person. We show that circulating level of LPS, acute phase", "butter_fingers": " hage attempted to elucidatt the role of the above kentiohed facturs in disease pathogenesis uy cimparung the plasma levels uf the vagious marjers un four groups of ludivismals: ehconic pathology individuans with or witvojt active filarial infection, asymptomwtic, fikagial infected yndiniquala and uninfected, endemic normal insividuans. We show thst circulating levels of LOS, afute phase", "random_deletion": "have attempted to elucidate the role of mentioned in disease by comparing the markers four groups of chronic pathology individuals or without active filarial infection, asymptomatic, infected individuals and uninfected, endemic normal individuals. We show that circulating levels of acute phase", "change_char_case": " have attempted to elucidate tHe role of thE abovE meNtiOnEd faCtorS in disease pathOGeneSis by comparing the plasmA leveLs OF the VArIous mArkers iN FoUR GroUpS oF inDiVIdUals: cHroNic pathOlogy indivIduAlS with or withoUT aCtive filarIal Infection, asyMptOmatic, FiLarIAl infEctEd indIviduaLS and unInfected, eNdEMic norMAl indivIDUaLs. We Show that circulatiNG lEVels of LPS, acute Phase", "whitespace_perturbation": " have attempted to elucida te the rol e ofthe  ab ov e me ntio ned factors in dise ase pathogenesis by co mpari ng thep la sma l evels o f  t h e  va ri ou s m ar k er s infou r group s of indiv idu al s: chronic p a th ology indi vid uals with or  wi thoutac tiv e  fila ria l inf ection ,  asymp tomatic,fi l ariali nfected i nd ivid uals and uninfect e d, endemic normal  indiv id u al s .  We  sh ow that ci rc ulati n g level s  o f L PS, acute phase", "underscore_trick": " have_attempted to_elucidate the role of_the above_mentioned_factors in_disease_pathogenesis by comparing_the plasma levels_of the various markers_in four groups_of_individuals: chronic pathology individuals with or without active filarial infection, asymptomatic, filarial infected individuals_and_uninfected, endemic_normal_individuals._We show that circulating levels_of LPS, acute phase"}
{"text": " performance-based instrumental activities of daily living; and c) health-related quality of life. 2) To determine if the cognitive interventions have beneficial effects on the distal outcomes of driving safety, personal care activities of daily living, health service utilization, and mortality. 3) To examine heath, genetic and cognitive moderators", "synonym_substitution": "performance - based instrumental activities of casual support; and c) health - related quality of biography. 2) To decide if the cognitive interventions have beneficial effect on the distal consequence of driving guard, personal care activities of casual living, health service utilization, and mortality. 3) To test heath, genetic and cognitive moderators", "butter_fingers": " pegformance-based instrumenual activities of daily niving; and c) hdalth-related quality of life. 2) Ro deuvrmine if the cognitixe intervvntions hqve ueneficial effecva on thc disfwl obtromes of drivinn safety, pessonal care acdixicies of daily living, health service ttilizayiln, and mortalijy. 3) Tp exajpnt heath, genetic and cognitive modsrators", "random_deletion": "performance-based instrumental activities of daily living; and quality life. 2) determine if the on distal outcomes of safety, personal care of daily living, health service utilization, mortality. 3) To examine heath, genetic and cognitive moderators", "change_char_case": " performance-based instrumenTal activitIes of DaiLy lIvIng; aNd c) hEalth-related quALity Of life. 2) To determine if the CogniTiVE intERvEntioNs have bENeFICiaL eFfEctS oN ThE distAl oUtcomes Of driving sAfeTy, Personal care ACtIvities of dAilY living, healtH seRvice uTiLizATion, aNd mOrtalIty. 3) To eXAmine hEath, genetIc ANd cognITive modERAtOrs", "whitespace_perturbation": " performance-based instrum ental acti vitie s o f d ai ly l ivin g; and c) heal t h-re lated quality of life.  2) T od eter m in e ifthe cog n it i v e i nt er ven ti o ns  have  be neficia l effectsonth e distal out c om es of driv ing  safety, per son al car eact i vitie s o f dai ly liv i ng, he alth serv ic e  utili z ation,a n dmort ality. 3) To exam i ne heath, genetic  and c og n it i v e m ode rators", "underscore_trick": " performance-based_instrumental activities_of daily living; and_c) health-related_quality_of life._2)_To determine if_the cognitive interventions_have beneficial effects on_the distal outcomes_of_driving safety, personal care activities of daily living, health service utilization, and mortality. 3)_To_examine heath,_genetic_and_cognitive moderators"}
{"text": " at NCI-Frederick, it lessens the number of transactions that SAIC-Frederick Research Contracts department will need to oversee, and the two-tier system significantly increases the number of vendors that can be contributing to the effort with a small number of contract technical managers/project officers. There are", "synonym_substitution": "at NCI - Frederick, it lessens the number of transactions that SAIC - Frederick Research Contracts department will need to oversee, and the two - grade arrangement significantly increases the numeral of seller that can be contributing to the effort with a small act of contract technical managers / project military officer. There are", "butter_fingers": " at NCI-Frederick, it lessens the number of jrqnsactmons thzt SAIC-Ffederick Research Contracts vepaetmenu will need to overree, and tje two-tiwr sbstem significanvmy incrccses fme nukuer of vendors jhat can be wontributing tm ghz effort with a small number of contwact tevhjical managers/krojebt offjbevs. There are", "random_deletion": "at NCI-Frederick, it lessens the number of SAIC-Frederick Contracts department need to oversee, increases number of vendors can be contributing the effort with a small number contract technical managers/project officers. There are", "change_char_case": " at NCI-Frederick, it lessens thE number of tRansaCtiOns ThAt SAiC-FrEderick ResearcH contRacts department will neeD to ovErSEe, anD ThE two-tIer systEM sIGNifIcAnTly InCReAses tHe nUmber of Vendors thaT caN bE contributinG To The effort wIth A small number Of cOntracT tEchNIcal mAnaGers/pRoject OFficerS. There are", "whitespace_perturbation": " at NCI-Frederick, it less ens the nu mberoftra ns acti onsthat SAIC-Fred e rick  Research Contracts de partm en t  wil l  n eed t o overs e e, a ndth etwo -t i er  syst emsignifi cantly inc rea se s the number of  vendors t hat  can be cont rib utingto  th e  effo rtwitha smal l  numbe r of cont ra c t tech n ical ma n a ge rs/p roject officers.T he r e are", "underscore_trick": " at_NCI-Frederick, it_lessens the number of_transactions that_SAIC-Frederick_Research Contracts_department_will need to_oversee, and the_two-tier system significantly increases_the number of_vendors_that can be contributing to the effort with a small number of contract technical_managers/project_officers. There_are"}
{"text": ". This ERV has intact open reading frames for all viral proteins, but has an unusual genomic structure and domain relationships to known retroviruses. Phylogenetic analysis failed to identify close relationships with known retroviruses and XTERV-LS is distinct from the 2 previously described X. tropicalis ERVs: XTERV", "synonym_substitution": ". This ERV has intact open reading human body for all viral protein, but has an unusual genomic social organization and domain kinship to known retroviruses. Phylogenetic psychoanalysis fail to identify close relationships with known retrovirus and XTERV - LS is distinct from the 2 previously described X. tropicalis ERVs: XTERV", "butter_fingers": ". Thls ERV has intact open rtading frames for all vical profeins, bug has an unusual genomic strnctuee ane domain relationships to known retrovieusew. Phylogenevjc analnfis rwileb vo identify cloxe relatiotships with knmwv xetroviruses and XTERV-LS is distinct from tne 2 previously dgscrinqd X. nripicalis ERVs: XTERV", "random_deletion": ". This ERV has intact open reading all proteins, but an unusual genomic known Phylogenetic analysis failed identify close relationships known retroviruses and XTERV-LS is distinct the 2 previously described X. tropicalis ERVs: XTERV", "change_char_case": ". This ERV has intact open readiNg frames foR all vIraL prOtEins, But hAs an unusual genOMic sTructure and domain relatIonshIpS To knOWn RetroViruses. pHyLOGenEtIc AnaLySIs FaileD to IdentifY close relaTioNsHips with knowN ReTroviruses And xTERV-LS is disTinCt from ThE 2 prEViousLy dEscriBed X. trOPicaliS ERVs: XTERv", "whitespace_perturbation": ". This ERV has intact open  reading f rames  fo r a ll  vir al p roteins, but h a s an  unusual genomic struc turean d  dom a in  rela tionshi p st o  kn ow nret ro v ir uses.  Ph ylogene tic analys isfa iled to iden t if y close re lat ionships wit h k nown r et rov i ruses  an d XTE RV-LSi s dist inct from  t h e 2 pr e viously d es crib ed X. tropicalisE RV s : XTERV", "underscore_trick": ". This_ERV has_intact open reading frames_for all_viral_proteins, but_has_an unusual genomic_structure and domain_relationships to known retroviruses._Phylogenetic analysis failed_to_identify close relationships with known retroviruses and XTERV-LS is distinct from the 2 previously_described_X. tropicalis_ERVs:_XTERV"}
{"text": " DCTD/CTEP, including inhibitors of molecular targets controlling stem cell proliferation and survival, angiogenesis, cell cycle progression and novel cytoreductive mechanisms like mitotic spindle inhibitors. Other PD assays in early to mid-development in the SAIC-Frederick PD program that will benefit from accelerated development and validation include assays", "synonym_substitution": "DCTD / CTEP, including inhibitors of molecular targets controlling shank cellular telephone proliferation and survival, angiogenesis, cell cycle progress and novel cytoreductive mechanism like mitotic spindle inhibitors. early PD assays in early to mid - development in the SAIC - Frederick PD plan that will benefit from accelerated development and establishment include assays", "butter_fingers": " DCHD/CTEP, including inhibiturs of moleculat rargetv contdolling rtem cell proliferation and duevivao, angiogenesis, cell cyzle progrvssion ane notel cytoreductivx mechanlfms mlke mntitic spindle ikhibitors. Odher PD assays iv zarly to mid-development in the SAIC-Fwedericl OD program thaj wilk bensfit from accelerated development znd valpdation include axsays", "random_deletion": "DCTD/CTEP, including inhibitors of molecular targets controlling proliferation survival, angiogenesis, cycle progression and spindle Other PD assays early to mid-development the SAIC-Frederick PD program that will from accelerated development and validation include assays", "change_char_case": " DCTD/CTEP, including inhibitoRs of molecuLar taRgeTs cOnTrolLing Stem cell prolifERatiOn and survival, angiogeneSis, ceLl CYcle PRoGressIon and nOVeL CYtoReDuCtiVe MEcHanisMs lIke mitoTic spindle InhIbItors. Other PD ASsAys in early To mId-developmenT in The SAIc-FRedERick Pd prOgram That wiLL benefIt from accElERated dEVelopmeNT AnD valIdation include assAYs", "whitespace_perturbation": " DCTD/CTEP, including inhi bitors ofmolec ula r t ar gets  con trolling stemc ellproliferation and surv ival,  a n giog e ne sis,cell cy c le p rog re ss ion  a n dnovel  cy toreduc tive mecha nis ms  like mitoti c  s pindle inh ibi tors. OtherPDassays  i n e a rly t o m id-de velopm e nt inthe SAIC- Fr e derick PD prog r a mthat  will benefit fro m  a c celerated deve lopmen ta nd v ali dat ion includ eassay s ", "underscore_trick": " DCTD/CTEP,_including inhibitors_of molecular targets controlling_stem cell_proliferation_and survival,_angiogenesis,_cell cycle progression_and novel cytoreductive_mechanisms like mitotic spindle_inhibitors. Other PD_assays_in early to mid-development in the SAIC-Frederick PD program that will benefit from accelerated_development_and validation_include_assays"}
{"text": "V-RA181T/N236T DNA, giving an IC50 value of 105. ADV moderately well blocked the synthesis of HBVWTCe and HBVETV-RL180M/S202G/M204V DNA, giving IC50 values of 1,163 and 30,770, respectively,", "synonym_substitution": "V - RA181T / N236 T DNA, giving an IC50 value of 105. ADV moderately well blocked the deduction of HBVWTCe and HBVETV - RL180M / S202G / M204V DNA, render IC50 values of 1,163 and 30,770, respectively,", "butter_fingers": "V-RA181H/N236T DNA, giving an IC50 valme of 105. ADV modercrely wxll blodked the synthesis of HBVWTCe and HBTETV-EL180M/S202G/N204V DNA, giving IC50 valuer of 1,163 and 30,770, respecriveot,", "random_deletion": "V-RA181T/N236T DNA, giving an IC50 value of moderately blocked the of HBVWTCe and of and 30,770, respectively,", "change_char_case": "V-RA181T/N236T DNA, giving an IC50 value oF 105. ADV moderaTely wEll BloCkEd thE synThesis of HBVWTCE And HbVETV-RL180M/S202G/M204V DNA, giving Ic50 valuEs OF 1,163 and 30,770, REsPectiVely,", "whitespace_perturbation": "V-RA181T/N236T DNA, giving  an IC50 v alueof105 .ADVmode rately well bl o cked  the synthesis of HBVW TCe a nd HBVE T V- RL180 M/S202G / M2 0 4 V D NA ,giv in g  I C50 v alu es of 1 ,163 and 3 0,7 70 , respective l y, ", "underscore_trick": "V-RA181T/N236T DNA,_giving an_IC50 value of 105._ADV moderately_well_blocked the_synthesis_of HBVWTCe and_HBVETV-RL180M/S202G/M204V DNA, giving_IC50 values of 1,163_and 30,770, respectively,"}
{"text": " were as high as 9 x 108/ml; however, the viremia levels significantly went down by day 7 of ETV administration and further viremia reduction occurred even after the termination of ETV administration to the lowest (by day 21). CMCP comparably blocked the replication of HBVWTCe under the", "synonym_substitution": "were as high as 9 x 108 / ml; however, the viremia levels significantly go down by sidereal day 7 of ETV administration and further viremia reduction occur even after the result of ETV administration to the lowest (by sidereal day 21). CMCP comparably blocked the replication of HBVWTCe under the", "butter_fingers": " wege as high as 9 x 108/ml; howeyer, the viremia levels vignifjcantly dent down by day 7 of ETV admmnisrratiin and further viremia reductioj occurrwd eten after the tecjinatiok of SBV adkmnistration to jhe lowest (bf day 21). CMCP cokpxrcbly blocked the replication of HBVWECe undrr the", "random_deletion": "were as high as 9 x 108/ml; viremia significantly went by day 7 viremia occurred even after termination of ETV to the lowest (by day 21). comparably blocked the replication of HBVWTCe under the", "change_char_case": " were as high as 9 x 108/ml; however, the Viremia levEls siGniFicAnTly wEnt dOwn by day 7 of ETV aDMiniStration and further vireMia reDuCTion OCcUrred Even aftER tHE TerMiNaTioN oF eTv admiNisTration To the lowesT (by DaY 21). CMCP comparaBLy Blocked the RepLication of HBvWTce undeR tHe", "whitespace_perturbation": " were as high as 9 x 108/m l; however , the  vi rem ia  lev elssignificantlyw entdown by day 7 of ETV a dmini st r atio n  a nd fu rther v i re m i a r ed uc tio no cc urred  ev en afte r the term ina ti on of ETV ad m in istrationtothe lowest ( byday 21 ).  CM C P com par ablyblocke d  the r eplicatio no f HBVW T Ce unde r th e", "underscore_trick": " were_as high_as 9 x 108/ml;_however, the_viremia_levels significantly_went_down by day_7 of ETV_administration and further viremia_reduction occurred even_after_the termination of ETV administration to the lowest (by day 21). CMCP comparably blocked_the_replication of_HBVWTCe_under_the"}
{"text": "; Eighty-two have been consented, fifty have completed both the survey and interview, with the remaining 32 currently in the process of completing assessments. In 2010 we completed recruitment and assessment on Project RAMA. In this study, we are investigating the dissemination process for complex disease risk information based on family health history and the", "synonym_substitution": "; Eighty - two have been consented, fifty have completed both the survey and interview, with the remain 32 presently in the process of completing assessment. In 2010 we complete recruitment and assessment on Project RAMA. In this study, we are investigate the dispersion process for complex disease risk information based on family health history and the", "butter_fingers": "; Eihhty-two have been consenued, fifty have completed both fhe survdy and interview, with the relauning 32 currently in the prozess of clmpletint aswwssments. Ii 2010 we completes recxumtment and assexsment on [roject RAMA. It ghns study, we are investigating the difseminayiln process for comklev diavawe risk information based on ramily iealth history snd the", "random_deletion": "; Eighty-two have been consented, fifty have the and interview, the remaining 32 completing In 2010 we recruitment and assessment Project RAMA. In this study, we investigating the dissemination process for complex disease risk information based on family health and the", "change_char_case": "; Eighty-two have been consenteD, fifty have ComplEteD boTh The sUrveY and interview, wITh thE remaining 32 currently in tHe proCeSS of cOMpLetinG assessMEnTS. in 2010 wE cOmPleTeD ReCruitMenT and assEssment on PRojEcT RAMA. In this sTUdY, we are inveStiGating the disSemInatioN pRocESs for ComPlex dIsease RIsk infOrmation bAsED on famILy healtH HIsTory And the", "whitespace_perturbation": "; Eighty-two have been con sented, fi fty h ave  co mp lete d bo th the surveya nd i nterview, with the rem ainin g3 2 cu r re ntlyin thep ro c e ssof  c omp le t in g ass ess ments.In 2010 we  co mp leted recrui t me nt and ass ess ment on Proj ect  RAMA.  I n t h is st udy , weare in v estiga ting thedi s semina t ion pro c e ss  for  complex diseaser is k  information b ased o nf am i l y h eal th history  a nd th e ", "underscore_trick": "; Eighty-two_have been_consented, fifty have completed_both the_survey_and interview,_with_the remaining 32_currently in the_process of completing assessments._In 2010 we_completed_recruitment and assessment on Project RAMA. In this study, we are investigating the dissemination_process_for complex_disease_risk_information based on family health_history and the"}
{"text": " modulation of striatal gating of DLPFC during the selective updating of wm content, which was predicted in computational models of wm function. Future studies using genetic assays and pharmacological manipulations to investigate this network will be needed to further support these claims. The group also investigated neurophysiological correlates of altered brain function associated", "synonym_substitution": "modulation of striatal gating of DLPFC during the selective updating of wm content, which was predicted in computational models of wm affair. Future cogitation using familial assay and pharmacological manipulations to investigate this network will be necessitate to further support these claim. The group also investigated neurophysiological correlate of altered brain function associated", "butter_fingers": " mofulation of striatal gatlng of DLPFC durnbg the selecfive updxting of wm content, which wad predixted in computational oodels of wm funcrion. Duture stuvjes usiky gensbic avways and pharmscological manipulations tu nnvestigate this network will be neeqed to gugther support jhese slaijs. The group also investigated neudophysimlogical corrrlates of altered brain fujctiln associated", "random_deletion": "modulation of striatal gating of DLPFC during updating wm content, was predicted in Future using genetic assays pharmacological manipulations to this network will be needed to support these claims. The group also investigated neurophysiological correlates of altered brain function", "change_char_case": " modulation of striatal gatinG of DLPFC duRing tHe sEleCtIve uPdatIng of wm content, WHich Was predicted in computatIonal MoDEls oF Wm FunctIon. FutuRE sTUDieS uSiNg gEnETiC assaYs aNd pharmAcological ManIpUlations to inVEsTigate this NetWork will be neEdeD to furThEr sUPport TheSe claIms. The GRoup alSo investiGaTEd neurOPhysiolOGIcAl coRrelates of altered BRaIN function assocIated", "whitespace_perturbation": " modulation of striatal ga ting of DL PFC d uri ngth e se lect ive updating o f  wmcontent, which was pre dicte di n co m pu tatio nal mod e ls o f w mfu nct io n .Futur e s tudiesusing gene tic  a ssays and ph a rm acological  ma nipulationstoinvest ig ate thisnet workwill b e  neede d to furt he r  suppo r t these c la ims.  The group also i n ve s tigated neurop hysiol og i ca l cor rel ates of al te red b r ain fun c ti o n ass o ciated", "underscore_trick": " modulation_of striatal_gating of DLPFC during_the selective_updating_of wm_content,_which was predicted_in computational models_of wm function. Future_studies using genetic_assays_and pharmacological manipulations to investigate this network will be needed to further support these_claims._The group_also_investigated_neurophysiological correlates of altered brain_function associated"}
{"text": " the crypt, Wnt-signaling is especially active. Presently, it is unclear what determines whether a subset of enteroendocrine cells remains in the Wnt signaling rich area instead of migrating up to the villi and why. Similar to other enteroendocrine cells, EC cells, the presumed cell of origin of", "synonym_substitution": "the crypt, Wnt - signaling is especially active. Presently, it is unclear what determine whether a subset of enteroendocrine cell remains in the Wnt signaling rich sphere instead of migrating up to the villi and why. alike to other enteroendocrine cells, EC cell, the presumed cell of lineage of", "butter_fingers": " thf crypt, Wnt-signaling is tspecially active. Presenvly, it js unclexr what determines whether a sybset of enteroendocrine ceuls remaijs in thw Wnu signaling rich edea insbzad or migxaving up to the yilli and wvy. Similar to mtfex enteroendocrine cells, EC cells, the presumrd cell of origig of", "random_deletion": "the crypt, Wnt-signaling is especially active. Presently, unclear determines whether subset of enteroendocrine signaling area instead of up to the and why. Similar to other enteroendocrine EC cells, the presumed cell of origin of", "change_char_case": " the crypt, Wnt-signaling is espEcially actIve. PrEseNtlY, iT is uNcleAr what determinES wheTher a subset of enteroendOcrinE cELls rEMaIns in The Wnt sIGnALIng RiCh AreA iNStEad of MigRating uP to the villI anD wHy. Similar to oTHeR enteroendOcrIne cells, EC ceLls, The preSuMed CEll of OriGin of", "whitespace_perturbation": " the crypt, Wnt-signalingis especia lly a cti ve.  P rese ntly , it is unclea r  wha t determines whether a  subs et of e n te roend ocrinec el l s  re ma in s i nt he  Wntsig nalingrich areains te ad of migrat i ng  up to the  vi lli and why.  Si milarto  ot h er en ter oendo crinec ells,EC cells,  t h e pres u med cel l of  ori gin of", "underscore_trick": " the_crypt, Wnt-signaling_is especially active. Presently,_it is_unclear_what determines_whether_a subset of_enteroendocrine cells remains_in the Wnt signaling_rich area instead_of_migrating up to the villi and why. Similar to other enteroendocrine cells, EC cells,_the_presumed cell_of_origin_of"}
{"text": "ogenic even in the face of strong pre-existing immunity to the vector. Next, we deleted the F and HN genes from HPIV3 and replaced them with EBOV GP to create a virus, HPIV3/delF-HN/EboGP, in which GP would be the sole viral transmembrane surface protein", "synonym_substitution": "ogenic even in the face of strong pre - existing immunity to the vector. Next, we edit the F and HN gene from HPIV3 and replaced them with EBOV GP to create a virus, HPIV3 / delF - HN / EboGP, in which GP would be the exclusive viral transmembrane airfoil protein", "butter_fingers": "ogejic even in the face of rtrong pre-existnbg immnnity tk the veztor. Next, we deleted the F aid HB gentf from HPIV3 and reolaced thvm with EVOV JP to create a vmdus, HPIY3/belF-HH/CboGP, mn which GP woukd be the vole viral tratsoelbrane surface protein", "random_deletion": "ogenic even in the face of strong to vector. Next, deleted the F and them with EBOV to create a HPIV3/delF-HN/EboGP, in which GP would be sole viral transmembrane surface protein", "change_char_case": "ogenic even in the face of stroNg pre-existIng imMunIty To The vEctoR. Next, we deleted THe F aNd HN genes from HPIV3 and rePlaceD tHEm wiTH EbOV GP To creatE A vIRUs, HpIv3/dElF-hN/eBogP, in wHicH GP woulD be the sole VirAl TransmembranE SuRface proteIn", "whitespace_perturbation": "ogenic even in the face of  strong pr e-exi sti ngim muni ty t o the vector.N ext,  we deleted the F andHN ge ne s  fro m  H PIV3and rep l ac e d  th em  w ith  E B OV  GP t o c reate a  virus, HP IV3 /d elF-HN/EboGP ,  i n which GP  wo uld be the s ole  viral  t ran s membr ane  surf ace pr o tein", "underscore_trick": "ogenic even_in the_face of strong pre-existing_immunity to_the_vector. Next,_we_deleted the F_and HN genes_from HPIV3 and replaced_them with EBOV_GP_to create a virus, HPIV3/delF-HN/EboGP, in which GP would be the sole viral transmembrane_surface_protein"}
{"text": " imaged the 3D position of the endocytic protein Epsin at single clathrin-coated structures in PC12 cells. From this work we discovered that Epsin sits at the equator of endocytic vesicles where it likely aids in the retrieval of clathrin-coated pits. We have continued to map dozens of", "synonym_substitution": "imaged the 3D position of the endocytic protein Epsin at single clathrin - coated structure in PC12 cell. From this work we discovered that Epsin sits at the equator of endocytic vesicle where it likely aids in the retrieval of clathrin - coat pits. We have continued to map tons of", "butter_fingers": " imwged the 3D position of tme endocytic projeun Epsmn at sjngle clxthrin-coated structures in PR12 ceols. Feom this work we discoxered than Epsin suts et the equator oh endocybnc vealcles xhere it likely aids in tve retrieval ox zlcthrin-coated pits. We have continued eo map coxens of", "random_deletion": "imaged the 3D position of the endocytic at clathrin-coated structures PC12 cells. From Epsin at the equator endocytic vesicles where likely aids in the retrieval of pits. We have continued to map dozens of", "change_char_case": " imaged the 3D position of the enDocytic proTein EPsiN at SiNgle ClatHrin-coated struCTureS in PC12 cells. From this work We disCoVEred THaT EpsiN sits at THe EQUatOr Of EndOcYTiC vesiCleS where iT likely aidS in ThE retrieval of CLaThrin-coateD piTs. We have contInuEd to maP dOzeNS of", "whitespace_perturbation": " imaged the 3D position of  the endoc yticpro tei nEpsi n at  single clathr i n-co ated structures in PC1 2 cel ls .  Fro m  t his w ork wed is c o ver ed  t hat  E p si n sit s a t the e quator ofend oc ytic vesicle s  w here it li kel y aids in th e r etriev al  of clath rin -coat ed pit s . We h ave conti nu e d to m a p dozen s of ", "underscore_trick": " imaged_the 3D_position of the endocytic_protein Epsin_at_single clathrin-coated_structures_in PC12 cells._From this work_we discovered that Epsin_sits at the_equator_of endocytic vesicles where it likely aids in the retrieval of clathrin-coated pits. We_have_continued to_map_dozens_of"}
{"text": "oxp sites to be inserted into the EpCAM locus. Embryonic stem cells with a targeted EpCAM allelle were generated and identified, and then utilized to generate the corresponding mice. Germline transmission of the targeted allele has been confirmed. We have now crossed mice with targeted EpCAM alleles with mice that express the", "synonym_substitution": "oxp sites to be inserted into the EpCAM locus. Embryonic stem cell with a target EpCAM allelle were generated and identified, and then use to beget the corresponding mice. Germline infection of the target allele has been confirmed. We have now crossed mice with targeted EpCAM allele with mice that express the", "butter_fingers": "oxp sites to be inserted inuo the EpCAM locus. Embrymnic sfem cellr with a targeted EpCAM alleplw wert generated and idevtified, ajd then ytilmzed to generate the corvzsponslng mncx. Germline tranxmission ox the targeted aulzle has been confirmed. We have now cwossed kife with targetgd EpBAI almvlts with mice that express the", "random_deletion": "oxp sites to be inserted into the Embryonic cells with targeted EpCAM allelle then to generate the mice. Germline transmission the targeted allele has been confirmed. have now crossed mice with targeted EpCAM alleles with mice that express the", "change_char_case": "oxp sites to be inserted into tHe EpCAM locUs. EmbRyoNic StEm ceLls wIth a targeted EpcaM alLelle were generated and iDentiFiED, and THeN utilIzed to gENeRATe tHe CoRreSpONdIng miCe. GErmline TransmissiOn oF tHe targeted alLElE has been coNfiRmed. We have noW crOssed mIcE wiTH targEteD EpCAm allelES with mIce that exPrESs the", "whitespace_perturbation": "oxp sites to be inserted i nto the Ep CAM l ocu s.Em bryo nicstem cells wit h  a t argeted EpCAM allellewerege n erat e dand i dentifi e d, a ndth en  ut il i ze d togen erate t he corresp ond in g mice. Germ l in e transmis sio n of the tar get ed all el e h a s bee n c onfir med. W e  havenow cross ed mice w i th targ e t ed  EpC AM alleles with m i ce that express t he", "underscore_trick": "oxp sites_to be_inserted into the EpCAM_locus. Embryonic_stem_cells with_a_targeted EpCAM allelle_were generated and_identified, and then utilized_to generate the_corresponding_mice. Germline transmission of the targeted allele has been confirmed. We have now crossed_mice_with targeted_EpCAM_alleles_with mice that express the"}
{"text": " J. Kuo, X. Han, C.T Hsiao, J. Yates, C. M. Waterman Focal adhesions (FAs) undergo contraction-mediated maturation wherein they grow and change composition to differentially transduce signals from the extracellular matrix to modulate cell migration, growth and differentiation", "synonym_substitution": "J. Kuo, X. Han, C.T Hsiao, J. Yates, C. M. Waterman Focal adhesions (FAs) undergo contraction - mediated maturation wherein they originate and transfer composition to differentially transduce signals from the extracellular matrix to modulate cellular telephone migration, growth and differentiation", "butter_fingers": " J. Nuo, X. Han, C.T Hsiao, J. Yatts, C. M. Waterman Focal adiesions (FAs) unddrgo contraction-mediated matnratuon wyerein they grow and cfange comiosition ro dmfferentially trehsduce signala frok the extracellolar matrix do modulate cenl mngration, growth and differentiation", "random_deletion": "J. Kuo, X. Han, C.T Hsiao, J. M. Focal adhesions undergo contraction-mediated maturation composition differentially transduce signals the extracellular matrix modulate cell migration, growth and differentiation", "change_char_case": " J. Kuo, X. Han, C.T Hsiao, J. Yates, C. M. WaTerman FocaL adheSioNs (Fas) UndeRgo cOntraction-mediATed mAturation wherein they grOw and ChANge cOMpOsitiOn to difFErENTiaLlY tRanSdUCe SignaLs fRom the eXtracellulAr mAtRix to modulatE CeLl migratioN, grOwth and diffeRenTiatioN", "whitespace_perturbation": " J. Kuo, X. Han, C.T Hsiao , J. Yates , C.M.Wat er manFoca l adhesions (F A s) u ndergo contraction-med iated  m a tura t io n whe rein th e yg r owan dcha ng e  c ompos iti on to d ifferentia lly  t ransduce sig n al s from the  ex tracellularmat rix to  m odu l ate c ell  migr ation, growth  and diff er e ntiati o n", "underscore_trick": " J._Kuo, X._Han, C.T Hsiao, J._Yates, C._M._Waterman Focal_adhesions_(FAs) undergo contraction-mediated_maturation wherein they_grow and change composition_to differentially transduce_signals_from the extracellular matrix to modulate cell migration, growth and differentiation"}
{"text": " and other signaling molecules. These defects were a direct result of a specific proteolysis of Gai2 GTPase subunit but not of other G&#945;i isoforms or family members. Loss of G&#945;i2 subunit was profound and was comparable to that of Nef induced CD4 degradation and was", "synonym_substitution": "and other signaling molecules. These defects were a direct resultant role of a specific proteolysis of Gai2 GTPase fractional monetary unit but not of other G&#945;i isoforms or family extremity. passing of G&#945;i2 subunit was profound and was comparable to that of Nef induce CD4 abasement and was", "butter_fingers": " anf other signaling molecuues. These defecjs were e direcf result of a specific proteolysis oh Gau2 GTPqse subunit but not of other G&#945;i isoformw or damily memusrs. Loss of G&#945;j2 subbnmt was profound and was cmmparable to tvag lf Nef induced CD4 degradation and wws", "random_deletion": "and other signaling molecules. These defects were result a specific of Gai2 GTPase G&#945;i or family members. of G&#945;i2 subunit profound and was comparable to that Nef induced CD4 degradation and was", "change_char_case": " and other signaling moleculeS. These defeCts weRe a DirEcT resUlt oF a specific protEOlysIs of Gai2 GTPase subunit buT not oF oTHer G&#945;I IsOformS or famiLY mEMBerS. LOsS of g&#945;i2 SUbUnit wAs pRofound And was compAraBlE to that of Nef INdUced CD4 degrAdaTion and was", "whitespace_perturbation": " and other signaling molec ules. Thes e def ect s w er e adire ct result of a spec ific proteolysis of Ga i2 GT Pa s e su b un it bu t not o f  o t h erG& #9 45; ii so forms  or  family  members.Los sof G&#945;i2 su bunit waspro found and wa s c ompara bl e t o  that  of  Nefinduce d  CD4 d egradatio na nd was ", "underscore_trick": " and_other signaling_molecules. These defects were_a direct_result_of a_specific_proteolysis of Gai2_GTPase subunit but_not of other G&#945;i_isoforms or family_members._Loss of G&#945;i2 subunit was profound and was comparable to that of Nef induced_CD4_degradation and_was"}
{"text": " of fully differentiated EC cells contributes to basal and pathological stem cell dynamics in the small intestine. These findings provide novel insights into the +4 reserve ISC hypothesis, stem cell dynamics of the intestinal epithelium and novel insight in the development of EC-derived small intestinal tumors. Take together, our studies suggest that Familial SI", "synonym_substitution": "of fully differentiated EC cells contributes to basal and diseased shank cell dynamics in the humble intestine. These finding provide novel insight into the +4 reserve ISC guess, stem cell dynamics of the intestinal epithelium and novel insight in the development of EC - derive small intestinal tumors. subscribe together, our studies suggest that Familial SI", "butter_fingers": " of fully differentiated EC cells contribujew to besal ans patholugical stem cell dynamics in tye smqll intestine. These fivdings prlvide nocel mnsights into thx +4 reseryz ISC mypotkewis, stem cell cynamics ox the intestindl e'ithelium and novel insight in the dqvelopmrnh of EC-derived smakj infvsuinal tumors. Take together, our sthdies slggest that Familoal SI", "random_deletion": "of fully differentiated EC cells contributes to pathological cell dynamics the small intestine. into +4 reserve ISC stem cell dynamics the intestinal epithelium and novel insight the development of EC-derived small intestinal tumors. Take together, our studies suggest that SI", "change_char_case": " of fully differentiated EC ceLls contribUtes tO baSal AnD patHoloGical stem cell dYNamiCs in the small intestine. THese fInDIngs PRoVide nOvel insIGhTS IntO tHe +4 ResErVE IsC hypOthEsis, steM cell dynamIcs Of The intestinaL EpIthelium anD noVel insight in The DeveloPmEnt OF EC-deRivEd smaLl inteSTinal tUmors. Take ToGEther, oUR studieS SUgGest That Familial SI", "whitespace_perturbation": " of fully differentiated E C cells co ntrib ute s t obasa l an d pathological stem  cell dynamics in thesmall  i n test i ne . The se find i ng s pro vi de  no ve l  i nsigh tsinto th e +4 reser veIS C hypothesis ,  s tem cell d yna mics of theint estina lepi t heliu m a nd no vel in s ight i n the dev el o pmento f EC-de r i ve d sm all intestinal tu m or s . Take togethe r, our  s t ud i e s s ugg est that F am ilial SI", "underscore_trick": " of_fully differentiated_EC cells contributes to_basal and_pathological_stem cell_dynamics_in the small_intestine. These findings_provide novel insights into_the +4 reserve_ISC_hypothesis, stem cell dynamics of the intestinal epithelium and novel insight in the development_of_EC-derived small_intestinal_tumors._Take together, our studies suggest_that Familial SI"}
{"text": " This important result proves that: a) the effect of the mutation is indeed due to reduction of TDP1 function and b) that the critically sensitive tissue is the nervous system. HIV-1 encodes genes that are crucial for replication in primate cells and whose function is not provided by the host. Gag, Pol", "synonym_substitution": "This important result proves that: a) the effect of the mutant is indeed due to decrease of TDP1 routine and b) that the critically sensitive tissue is the skittish organization. HIV-1 encodes genes that are crucial for replica in archpriest cells and whose function is not provided by the host. Gag, Pol", "butter_fingers": " Thls important result provts that: a) the effgcr of tie mutafion is kndeed due to reduction of TVP1 fynctiin and b) that the critkcally sejsitive rissne is the nervous system. HIV-1 ehgodes jenes that are grucial for replication it ornmate cells and whose function is noe provicef by the host. Dag, Kol", "random_deletion": "This important result proves that: a) the the is indeed to reduction of the sensitive tissue is nervous system. HIV-1 genes that are crucial for replication primate cells and whose function is not provided by the host. Gag, Pol", "change_char_case": " This important result proves That: a) the efFect oF thE muTaTion Is inDeed due to reducTIon oF TDP1 function and b) that thE critIcALly sENsItive Tissue iS ThE NErvOuS sYstEm. hiV-1 EncodEs gEnes thaT are cruciaL foR rEplication in PRiMate cells aNd wHose function Is nOt provIdEd bY The hoSt. GAg, Pol", "whitespace_perturbation": " This important result pro ves that:a) th e e ffe ct  ofthemutation is in d eeddue to reduction of TD P1 fu nc t iona nd  b) t hat the cr i t ica ll ysen si t iv e tis sue  is the  nervous s yst em . HIV-1 enco d es  genes tha t a re crucial f orreplic at ion in pr ima te ce lls an d  whose  function  i s  not p r ovidedb y  t he h ost. Gag, Pol", "underscore_trick": " This_important result_proves that: a) the_effect of_the_mutation is_indeed_due to reduction_of TDP1 function_and b) that the_critically sensitive tissue_is_the nervous system. HIV-1 encodes genes that are crucial for replication in primate cells_and_whose function_is_not_provided by the host. Gag,_Pol"}
{"text": " maintenance of IADL function as hypothesized. The Specific Aims of this extended follow-up are to: 1) To determine if the cognitive interventions continue to have protective effects up to 10 years after initial training: a) basic cognitive abilities of memory, reasoning, and speed or processing; b) self- reported and", "synonym_substitution": "maintenance of IADL function as hypothesized. The Specific Aims of this extended follow - up are to: 1) To settle if the cognitive interposition continue to have protective effects up to 10 long time after initial training: a) basic cognitive abilities of memory, reasoning, and amphetamine or processing; b) self- report and", "butter_fingers": " malntenance of IADL functiun as hypothesieee. The Vpecifjc Aims uf this extended follow-up arx to: 1) To eetermine if the cognigive integventions conuinue to have provsctive cyfecta up co 10 years after lnitial trahning: a) basic woenntive abilities of memory, reasoning, wnd sperd or processing; b) stlf- repkgttd and", "random_deletion": "maintenance of IADL function as hypothesized. The of extended follow-up to: 1) To continue have protective effects to 10 years initial training: a) basic cognitive abilities memory, reasoning, and speed or processing; b) self- reported and", "change_char_case": " maintenance of IADL function As hypothesIzed. THe SPecIfIc AiMs of This extended foLLow-uP are to: 1) To determine if the CogniTiVE intERvEntioNs contiNUe TO HavE pRoTecTiVE eFfectS up To 10 years After initiAl tRaIning: a) basic cOGnItive abiliTieS of memory, reaSonIng, and SpEed OR procEssIng; b) sElf- repORted anD", "whitespace_perturbation": " maintenance of IADL funct ion as hyp othes ize d.Th e Sp ecif ic Aims of thi s  ext ended follow-up are to : 1)To dete r mi ne if  the co g ni t i vein te rve nt i on s con tin ue to h ave protec tiv eeffects up t o  1 0 years af ter  initial tra ini ng: a)  b asi c  cogn iti ve ab ilitie s  of me mory, rea so n ing, a n d speed o rproc essing; b) self-r ep o rted and", "underscore_trick": " maintenance_of IADL_function as hypothesized. The_Specific Aims_of_this extended_follow-up_are to: 1)_To determine if_the cognitive interventions continue_to have protective_effects_up to 10 years after initial training: a) basic cognitive abilities of memory, reasoning,_and_speed or_processing;_b)_self- reported and"}
{"text": " of ISC marker-expressing enteroendocrine cells in the human small intestine and whether they are related to SI-NETs. Therefore, we are presently investigating the relationship between the expression of ISC marker genes in EC cells along the crypt-villus axis of the human norman ileum and their expressions in", "synonym_substitution": "of ISC marker - expressing enteroendocrine cells in the human small intestine and whether they are related to SI - NETs. consequently, we are soon investigate the relationship between the formula of ISC marker gene in EC cells along the crypt - villus axis of the human norman ileum and their expressions in", "butter_fingers": " of ISC marker-expressing enueroendocrine cells in tie humah small kntestine and whether they ace rwlatee to SI-NETs. Therefore, de are prvsently ibvesuigating the relavjonship betwesk the xxpression of IXC marker cenes in EC cenlr clong the crypt-villus axis of the huian norkaj ileum and thgir eqpwessjons in", "random_deletion": "of ISC marker-expressing enteroendocrine cells in the intestine whether they related to SI-NETs. the between the expression ISC marker genes EC cells along the crypt-villus axis the human norman ileum and their expressions in", "change_char_case": " of ISC marker-expressing enteRoendocrinE cellS in The HuMan sMall Intestine and whETher They are related to SI-NETs. thereFoRE, we aRE pResenTly inveSTiGATinG tHe RelAtIOnShip bEtwEen the eXpression oF ISc mArker genes in ec cElls along tHe cRypt-villus axIs oF the huMaN noRMan ilEum And thEir expREssionS in", "whitespace_perturbation": " of ISC marker-expressingenteroendo crine  ce lls  i n th e hu man small inte s tine  and whether they arerelat ed to S I -N ETs.Therefo r e, w e a re  p res en t ly  inve sti gatingthe relati ons hi p between th e  e xpressionofISC marker g ene s in E Ccel l s alo ngthe c rypt-v i llus a xis of th eh uman n o rman il e u mandtheir expressions in ", "underscore_trick": " of_ISC marker-expressing_enteroendocrine cells in the_human small_intestine_and whether_they_are related to_SI-NETs. Therefore, we_are presently investigating the_relationship between the_expression_of ISC marker genes in EC cells along the crypt-villus axis of the human_norman_ileum and_their_expressions_in"}
{"text": " year outcome data in 26 patients with NOMID who have been receiving escalating doses of anakinra. The initially observed good clinical response to anakinra persists, the drug is overall well tolerated. In most patients hearing and vision was persevered over 3 and 5 years, however patients who experienced hearing loss on", "synonym_substitution": "year outcome data in 26 patients with NOMID who have been pick up escalate doses of anakinra. The initially observed beneficial clinical answer to anakinra persists, the drug is overall well tolerated. In most patients hear and imagination was persevered over 3 and 5 old age, however patients who experienced hear loss on", "butter_fingers": " yewr outcome data in 26 patitnts with NOMID wki have been deceivine escalating doses of anakinca. Tye inutially observed good zlinical gesponse ro aiakinra persists, the drun is kyeraln well toleratec. In most [atients hearitg aud vision was persevered over 3 and 5 rears, hpwfver patients rho txpqriehbeb hearing loss on", "random_deletion": "year outcome data in 26 patients with have receiving escalating of anakinra. The to persists, the drug overall well tolerated. most patients hearing and vision was over 3 and 5 years, however patients who experienced hearing loss on", "change_char_case": " year outcome data in 26 patients With NOMID wHo havE beEn rEcEiviNg esCalating doses oF AnakInra. The initially observEd gooD cLInicAL rEsponSe to anaKInRA PerSiStS, thE dRUg Is oveRalL well toLerated. In mOst PaTients hearinG AnD vision was PerSevered over 3 aNd 5 yEars, hoWeVer PAtienTs wHo expEriencED heariNg loss on", "whitespace_perturbation": " year outcome data in 26 p atients wi th NO MID  wh ohave  bee n receiving es c alat ing doses of anakinra.  Thein i tial l yobser ved goo d  c l i nic al  r esp on s eto an aki nra per sists, the  dr ug  is overallw el l tolerate d.In most pati ent s hear in g a n d vis ion  waspersev e red ov er 3 and5y ears,h oweverp a ti ents  who experiencedh ea r ing loss on", "underscore_trick": " year_outcome data_in 26 patients with_NOMID who_have_been receiving_escalating_doses of anakinra._The initially observed_good clinical response to_anakinra persists, the_drug_is overall well tolerated. In most patients hearing and vision was persevered over 3_and_5 years,_however_patients_who experienced hearing loss on"}
{"text": " providing a clinically relevant alternative to IN administration. In summary, NDV has considerable potential for further development as a highly attenuated vector for human vaccine use. NDV represents serotype 1 of the avian paramyxoviruses (APMV). There are 8 other serotypes, namely APMV2-9. We have initiated", "synonym_substitution": "providing a clinically relevant alternative to IN administration. In summary, NDV has considerable electric potential for further growth as a highly attenuated vector for human vaccine use. NDV represent serotype 1 of the avian paramyxovirus (APMV). There are 8 other serotypes, namely APMV2 - 9. We have initiated", "butter_fingers": " prlviding a clinically reltvant alternative to IN edminisfration. Kn summary, NDV has consideraule potenupal for further develupment as a highlt atuenuated vector for human vaccihc use. IDV represents xerotype 1 mf the avian pdrxmvxoviruses (APMV). There are 8 other serjtypes, malely APMV2-9. We hwve pnytiafvd", "random_deletion": "providing a clinically relevant alternative to IN summary, has considerable for further development for vaccine use. NDV serotype 1 of avian paramyxoviruses (APMV). There are 8 serotypes, namely APMV2-9. We have initiated", "change_char_case": " providing a clinically relevAnt alternaTive tO IN AdmInIstrAtioN. In summary, NDV hAS conSiderable potential for fUrtheR dEVeloPMeNt as a Highly aTTeNUAteD vEcTor FoR HuMan vaCciNe use. NDv representS seRoType 1 of the aviAN pAramyxovirUseS (APMV). There arE 8 otHer serOtYpeS, NamelY APmV2-9. We hAve iniTIated", "whitespace_perturbation": " providing a clinically re levant alt ernat ive  to  I N ad mini stration. In s u mmar y, NDV has considerabl e pot en t ialf or  furt her dev e lo p m ent  a sa h ig h ly  atte nua ted vec tor for hu man  v accine use.N DV  represent s s erotype 1 of  th e avia npar a myxov iru ses ( APMV). Thereare 8 oth er seroty p es, nam e l yAPMV 2-9. We have init i at e d", "underscore_trick": " providing_a clinically_relevant alternative to IN_administration. In_summary,_NDV has_considerable_potential for further_development as a_highly attenuated vector for_human vaccine use._NDV_represents serotype 1 of the avian paramyxoviruses (APMV). There are 8 other serotypes, namely_APMV2-9._We have_initiated"}
{"text": " are from merozoites, antigens present on the surface of the infected red cell have significant advantages as targets because of their exposure to the serum for long periods. However, the antigenic complexity and diversity of the known surface molecules (e.g., PfEMP1) have proven daunting for vaccine development. To", "synonym_substitution": "are from merozoites, antigens present on the surface of the infected red cellular telephone take significant advantages as target because of their photograph to the serum for long periods. However, the antigenic complexity and diverseness of the known surface molecules (e.g., PfEMP1) have prove daunting for vaccine development. To", "butter_fingers": " arf from merozoites, antigeks present on thg wurfacx of ths infectdd red cell have significant aevantqges as targets becausd of theig exposurw to rhe serum hkr long periosd. Hoceter, the antigenlc complexidy and diversidy oy the known surface molecules (e.g., PfEIP1) have pgoven daunting for daccjne development. To", "random_deletion": "are from merozoites, antigens present on the the red cell significant advantages as to serum for long However, the antigenic and diversity of the known surface (e.g., PfEMP1) have proven daunting for vaccine development. To", "change_char_case": " are from merozoites, antigens Present on tHe surFacE of ThE infEcteD red cell have siGNifiCant advantages as targetS becaUsE Of thEIr ExposUre to thE SeRUM foR lOnG peRiODs. howevEr, tHe antigEnic compleXitY aNd diversity oF ThE known surfAce Molecules (e.g., PFEMp1) have pRoVen DAuntiNg fOr vacCine deVElopmeNt. To", "whitespace_perturbation": " are from merozoites, anti gens prese nt on  th e s ur face  ofthe infected r e d ce ll have significant ad vanta ge s  ast ar getsbecause of t hei rex pos ur e  t o the  se rum for  long peri ods .However, the an tigenic co mpl exity and di ver sity o fthe known  su rface  molec u les (e .g., PfEM P1 )  havep roven d a u nt ingfor vaccine devel o pm e nt. To", "underscore_trick": " are_from merozoites,_antigens present on the_surface of_the_infected red_cell_have significant advantages_as targets because_of their exposure to_the serum for_long_periods. However, the antigenic complexity and diversity of the known surface molecules (e.g., PfEMP1)_have_proven daunting_for_vaccine_development. To"}
{"text": " treatment. These data suggest that treatment with anakinra not only controls disease symptoms and inflammatory blood markers but can also prevent the progression of organ damage. Studies to assess the prevention of any organ damage in very young children are ongoing. 2. Disability on treatment with anakinra significantly improvement and persisted up to 3 and", "synonym_substitution": "treatment. These data suggest that treatment with anakinra not merely operate disease symptoms and inflammatory blood marker but can also prevent the progression of harmonium wrong. Studies to measure the prevention of any organ damage in very unseasoned children are ongoing. 2. Disability on treatment with anakinra importantly improvement and persisted up to 3 and", "butter_fingers": " trfatment. These data suggert that treatmeur with anakihra not unly controls disease symptols and unflammatory blood maryers but ban also prevtnt the progression of orncn dajwge. Vvudies to assesx the prevantion of any mreau damage in very young children are jngoing. 2. Fisability on jreatkqnt sptm anakinra significantly improvejent anv persisted up yo 3 and", "random_deletion": "treatment. These data suggest that treatment with only disease symptoms inflammatory blood markers progression organ damage. Studies assess the prevention any organ damage in very young are ongoing. 2. Disability on treatment with anakinra significantly improvement and persisted up 3 and", "change_char_case": " treatment. These data suggest That treatmEnt wiTh aNakInRa noT onlY controls diseaSE symPtoms and inflammatory blOod maRkERs buT CaN also Prevent THe PROgrEsSiOn oF oRGaN damaGe. STudies tO assess the PreVeNtion of any orGAn Damage in veRy yOung children Are OngoinG. 2. DIsaBIlity On tReatmEnt witH AnakinRa signifiCaNTly impROvement AND pErsiSted up to 3 and", "whitespace_perturbation": " treatment. These data sug gest thattreat men t w it h an akin ra not only co n trol s disease symptoms and  infl am m ator y  b loodmarkers bu t can  a ls o p re v en t the  pr ogressi on of orga n d am age. Studies to  assess th e p revention of  an y orga ndam a ge in  ve ry yo ung ch i ldrenare ongoi ng .  2. Di s ability o ntrea tment with anakin r as ignificantly i mprove me n ta n d p ers isted up t o3 and ", "underscore_trick": " treatment._These data_suggest that treatment with_anakinra not_only_controls disease_symptoms_and inflammatory blood_markers but can_also prevent the progression_of organ damage._Studies_to assess the prevention of any organ damage in very young children are ongoing._2._Disability on_treatment_with_anakinra significantly improvement and persisted_up to 3 and"}
{"text": " EpCAM-expressing Langerhans cells after antigen-induced activation. This results in decreased migration of Langerhans cells from skin to regional lymph nodes and enhanced contact sensitivity reactions. These results definitively linking Langerhans cell migration to function and support the concept that Langerhans cells have a anti", "synonym_substitution": "EpCAM - expressing Langerhans cells after antigen - induced activation. This result in decrease migration of Langerhans cells from skin to regional lymph nodes and enhance contact sensitivity reactions. These resultant role definitively yoke Langerhans cell migration to serve and support the concept that Langerhans cells get a anti", "butter_fingers": " EpFAM-expressing Langerhans cells after anjiten-indnced acfivation. This results in decreased mmgrarion if Langerhans cells frum skin tl regionql lbmph nodes and eiganced gjntadb senvmtivity reactioks. These revults definitieeuy linking Langerhans cell migration eo funcyiln and support the soncsit that Langerhans cells have a anti", "random_deletion": "EpCAM-expressing Langerhans cells after antigen-induced activation. This decreased of Langerhans from skin to contact reactions. These results linking Langerhans cell to function and support the concept Langerhans cells have a anti", "change_char_case": " EpCAM-expressing Langerhans Cells after AntigEn-iNduCeD actIvatIon. This results IN decReased migration of LangeRhans CeLLs frOM sKin to RegionaL LyMPH noDeS aNd eNhANcEd conTacT sensitIvity reactIonS. THese results dEFiNitively liNkiNg Langerhans CelL migraTiOn tO FunctIon And suPport tHE concePt that LanGeRHans ceLLs have a ANTi", "whitespace_perturbation": " EpCAM-expressing Langerha ns cells a fterant ige n- indu cedactivation. Th i s re sults in decreased mig ratio no f La n ge rhans  cellsf ro m ski nto  re gi o na l lym phnodes a nd enhance d c on tact sensiti v it y reaction s.These result s d efinit iv ely linki ngLange rhansc ell mi gration t of unctio n  and su p p or t th e concept that La n ge r hans cells hav e a an ti ", "underscore_trick": " EpCAM-expressing_Langerhans cells_after antigen-induced activation. This_results in_decreased_migration of_Langerhans_cells from skin_to regional lymph_nodes and enhanced contact_sensitivity reactions. These_results_definitively linking Langerhans cell migration to function and support the concept that Langerhans cells_have_a anti"}
{"text": " may improve glucose tolerance in children. In non-overweight children, we found that Interrupting sitting resulted in a 32% lower insulin Area Under the Curve (AUC; P <.001), 17% lower C-peptide AUC (P <.001), and 7% lower glucose AUC (P =.018", "synonym_substitution": "may improve glucose tolerance in children. In non - overweight child, we discover that Interrupting sitting resulted in a 32% lower insulin Area Under the Curve (united self-defense force of colombia; P < .001), 17% lower C - peptide united self-defense force of colombia (phosphorus < .001), and 7% lower glucose AUC (P = .018", "butter_fingers": " maj improve glucose tolerakce in children. Nb non-oterweiggt childfen, we found that Interruptiig suttint resulted in a 32% lower insulin Wrea Undwr tie Curve (AUC; P <.001), 17% lower C-izptids AUC (' <.001), and 7% lower gkucose AUC (P =.018", "random_deletion": "may improve glucose tolerance in children. In we that Interrupting resulted in a the (AUC; P <.001), lower C-peptide AUC <.001), and 7% lower glucose AUC =.018", "change_char_case": " may improve glucose tolerancE in childreN. In noN-ovErwEiGht cHildRen, we found that iNterRupting sitting resulted In a 32% loWeR InsuLIn area UNder the cUrVE (aUC; p <.001), 17% lOwEr C-PePTiDe AUC (p <.001), anD 7% lower gLucose AUC (P =.018", "whitespace_perturbation": " may improve glucose toler ance in ch ildre n.Inno n-ov erwe ight children, we f ound that Interrupting  sitt in g  res u lt ed in  a 32%l ow e r  in su li n A re a  U nderthe  Curve(AUC; P <. 001 ),  17% lower C - pe ptide AUC(P<.001), and7%lowergl uco s e AUC  (P  =.01 8", "underscore_trick": " may_improve glucose_tolerance in children. In_non-overweight children,_we_found that_Interrupting_sitting resulted in_a 32% lower_insulin Area Under the_Curve (AUC; P_<.001),_17% lower C-peptide AUC (P <.001), and 7% lower glucose AUC (P =.018"}
{"text": " the manufacture of PCBs has been banned worldwide, they persist in measurable amounts in nearly everyone in developed countries. Animal and human data suggest that PCBs interfere with thyroid hormone metabolism and are neurotoxic even at levels found in background-exposed humans. Epidemiologic data on health effects guide advisories regarding fish consumption and are", "synonym_substitution": "the manufacture of PCBs has been banned worldwide, they persist in measurable amounts in about everyone in modernize countries. Animal and human data suggest that PCBs intervene with thyroid hormone metabolism and are neurotoxic even at levels establish in background - exposed humans. Epidemiologic data on health effects lead advisories regarding pisces pulmonary tuberculosis and are", "butter_fingers": " thf manufacture of PCBs har been banned worldwidx, they lersist kn measurable amounts in neacly wveryine in developed countfies. Animwl and hyman eata suggest that IEBs ihberfexe with thyroid mormone metdbolism and ara vebrotoxic even at levels found in bachground-rxoosed humans. Ekidempojogid data on health effects guide advjsories regarding fixh consumption and are", "random_deletion": "the manufacture of PCBs has been banned persist measurable amounts nearly everyone in data that PCBs interfere thyroid hormone metabolism are neurotoxic even at levels found background-exposed humans. Epidemiologic data on health effects guide advisories regarding fish consumption and", "change_char_case": " the manufacture of PCBs has beEn banned woRldwiDe, tHey PeRsisT in mEasurable amounTS in nEarly everyone in developEd couNtRIes. ANImAl and Human daTA sUGGesT tHaT PCbs INtErferE wiTh thyroId hormone mEtaBoLism and are neURoToxic even aT leVels found in bAckGround-ExPosED humaNs. EPidemIologiC Data on Health effEcTS guide ADvisoriES ReGardIng fish consumptioN AnD Are", "whitespace_perturbation": " the manufacture of PCBs h as been ba nnedwor ldw id e, t heypersist in mea s urab le amounts in nearly e veryo ne in d e ve loped  countr i es . Ani ma land  h u ma n dat a s uggestthat PCBsint er fere with th y ro id hormone  me tabolism and  ar e neur ot oxi c  even  at  leve ls fou n d in b ackground -e x posedh umans.E p id emio logic data on hea l th effects guideadviso ri e sr e gar din g fish con su mptio n  and ar e ", "underscore_trick": " the_manufacture of_PCBs has been banned_worldwide, they_persist_in measurable_amounts_in nearly everyone_in developed countries._Animal and human data_suggest that PCBs_interfere_with thyroid hormone metabolism and are neurotoxic even at levels found in background-exposed humans._Epidemiologic_data on_health_effects_guide advisories regarding fish consumption_and are"}
{"text": ". The results of primer extension provided strong evidence that the mutations in RNase H specifically inhibited the removal of the PPT RNA from the 5? end of the plus strand. As a result, our data identified a cluster of conserved amino acids in RNase H that have the specific function of removing the PPT. [unreadable]", "synonym_substitution": ". The results of primer extension provided impregnable evidence that the mutation in RNase H specifically inhibited the removal of the PPT RNA from the 5? end of the plus strand. As a solution, our data identified a bunch of conserved amino acids in RNase H that have the specific affair of removing the PPT. [ unreadable ]", "butter_fingers": ". Thf results of primer exteksion provided sjring evmdence fhat the mutations in RNase H specifmcaloy inyibited the removal of the PPT GNA from rhe 5? wnd of the plus stvcnd. Aa a rzsnlt, our data idgntified a cnuster of consarxeb amino acids in RNase H that have tre specoflc function of rempding nht PPT. [unreadable]", "random_deletion": ". The results of primer extension provided that mutations in H specifically inhibited RNA the 5? end the plus strand. a result, our data identified a of conserved amino acids in RNase H that have the specific function of the PPT. [unreadable]", "change_char_case": ". The results of primer extensiOn provided StronG evIdeNcE thaT the Mutations in RNaSE H spEcifically inhibited the RemovAl OF the ppT rNA frOm the 5? enD Of THE plUs StRanD. AS A rEsult, Our Data ideNtified a clUstEr Of conserved aMInO acids in RNAse h that have the SpeCific fUnCtiON of reMovIng thE PPT. [unREadablE]", "whitespace_perturbation": ". The results of primer ex tension pr ovide d s tro ng  evi denc e that the mut a tion s in RNase H specifica lly i nh i bite d  t he re moval o f  t h e  PP TRN A f ro m  t he 5?  en d of th e plus str and .As a result, ou r data ide nti fied a clust erof con se rve d  amin o a cidsin RNa s e H th at have t he specif i c funct i o nof r emoving the PPT.[ un r eadable]", "underscore_trick": ". The_results of_primer extension provided strong_evidence that_the_mutations in_RNase_H specifically inhibited_the removal of_the PPT RNA from_the 5? end_of_the plus strand. As a result, our data identified a cluster of conserved amino_acids_in RNase_H_that_have the specific function of_removing the PPT. [unreadable]"}
{"text": " proteins, such as receptors, channels, and their regulatory partners, are typically synthesized by ribosome?s associated with the endoplasmic reticulum, but ultimately function at the cell surface. Thus, the logistics of their production, assembly, transport, and exocytotic insertion into the cell surface is key to understanding both normal physiological", "synonym_substitution": "proteins, such as receptors, channels, and their regulatory partner, are typically synthesize by ribosome?s associated with the endoplasmic reticulum, but ultimately function at the cell airfoil. Thus, the logistics of their production, forum, tape drive, and exocytotic insertion into the cellular telephone open is key to understand both normal physiological", "butter_fingers": " prlteins, such as receptors, channels, and tkwir rejulatorg partnefs, are typically synthesized bt ribisome?s associated with the endoilasmic rwticnlum, but ultimatxmy funcbnon af the rell surface. Thos, the logisdics of their [rudbction, assembly, transport, and exocytjtic inxegtion into the celk surrace is key to understanding both hormal khysiological", "random_deletion": "proteins, such as receptors, channels, and their are synthesized by associated with the at cell surface. Thus, logistics of their assembly, transport, and exocytotic insertion into cell surface is key to understanding both normal physiological", "change_char_case": " proteins, such as receptors, chAnnels, and tHeir rEguLatOrY parTnerS, are typically sYNtheSized by ribosome?s associAted wItH The eNDoPlasmIc reticULuM, BUt uLtImAteLy FUnCtion At tHe cell sUrface. Thus, The LoGistics of theIR pRoduction, aSseMbly, transporT, anD exocyToTic INsertIon Into tHe cell SUrface Is key to unDeRStandiNG both noRMAl PhysIological", "whitespace_perturbation": " proteins, such as recepto rs, channe ls, a ndthe ir  reg ulat ory partners,a re t ypically synthesized b y rib os o me?s as socia ted wit h  t h e  en do pl asm ic re ticul um,  but ul timately f unc ti on at the ce l lsurface. T hus , the logist ics  of th ei r p r oduct ion , ass embly, transp ort, andex o cytoti c  insert i o ninto  the cell surface is key to underst anding  b o th n orm alphysiologi ca l", "underscore_trick": " proteins,_such as_receptors, channels, and their_regulatory partners,_are_typically synthesized_by_ribosome?s associated with_the endoplasmic reticulum,_but ultimately function at_the cell surface._Thus,_the logistics of their production, assembly, transport, and exocytotic insertion into the cell surface_is_key to_understanding_both_normal physiological"}
{"text": "-mentioned factors in disease pathogenesis by comparing the plasma levels of the various markers in four groups of individuals: chronic pathology individuals with or without active filarial infection; asymptomatic, filaria-infected individuals; and uninfected, endemic normal individuals. We show that altered ratios of the metalloproteinases and their inhibitorsas well as", "synonym_substitution": "-mentioned factors in disease pathogenesis by comparing the plasma levels of the various marker in four group of individuals: chronic pathology individuals with or without active filarial infection; asymptomatic, filaria - infect individuals; and uninfected, endemic normal individual. We express that altered ratio of the metalloproteinases and their inhibitorsas well as", "butter_fingers": "-menhioned factors in diseast pathogenesis by comparmng the plasma uevels of the various markerd un foyr groups of individuaus: chronib patholoty iidividuals with or withomc actjye finerial infection; asymptomadic, filaria-infacgeb individuals; and uninfected, endemic normal ijdividuals. We fhow ehat altered ratios of the metalloprotsinases and their innibitorsas well as", "random_deletion": "-mentioned factors in disease pathogenesis by comparing levels the various in four groups with without active filarial asymptomatic, filaria-infected individuals; uninfected, endemic normal individuals. We show altered ratios of the metalloproteinases and their inhibitorsas well as", "change_char_case": "-mentioned factors in disease PathogenesIs by cOmpAriNg The pLasmA levels of the vaRIous Markers in four groups of iNdiviDuALs: chROnIc patHology iNDiVIDuaLs WiTh oR wIThOut acTivE filariAl infectioN; asYmPtomatic, filaRIa-Infected inDivIduals; and uniNfeCted, enDeMic NOrmal IndIviduAls. We sHOw that Altered raTiOS of the MEtallopROTeInasEs and their inhibitORsAS well as", "whitespace_perturbation": "-mentioned factors in dise ase pathog enesi s b y c om pari ng t he plasma leve l s of  the various markers i n fou rg roup s  o f ind ividual s :c h ron ic  p ath ol o gy  indi vid uals wi th or with out  a ctive filari a linfection;  as ymptomatic,fil aria-i nf ect e d ind ivi duals ; andu ninfec ted, ende mi c  norma l  indivi d u al s. W e show that alter e dr atios of the m etallo pr o te i n ase s a nd their i nh ibito r sas wel l  a s ", "underscore_trick": "-mentioned factors_in disease_pathogenesis by comparing the_plasma levels_of_the various_markers_in four groups_of individuals: chronic_pathology individuals with or_without active filarial_infection;_asymptomatic, filaria-infected individuals; and uninfected, endemic normal individuals. We show that altered ratios of_the_metalloproteinases and_their_inhibitorsas_well as"}
{"text": " synthesis with an 11 nucleotide RNA removed from the 5? end of its own transcript. We tested whether the self-primer of Tf1 was similar to tRNA primers in being removed from the cDNA by RNase H. Our analysis of Tf1 cDNA extracted from virus-like particles revealed the surprising observation that the dominant", "synonym_substitution": "synthesis with an 11 nucleotide RNA removed from the 5? end of its own transcript. We tested whether the self - fuse of Tf1 was exchangeable to tRNA primers in being removed from the cDNA by RNase H. Our psychoanalysis of Tf1 cDNA extracted from virus - like atom revealed the surprising observation that the dominant allele", "butter_fingers": " syjthesis with an 11 nucleotlde RNA removed yeom thx 5? end kf its odn transcript. We tested whetier rhe stjf-primer of Tf1 was similar no tRNA peimecs in being remotsd from the cSKA by CNase H. Our anakysis of Tx1 cDNA extractad fxom virus-like particles revealed the surprixijg observation thau tre dkminant", "random_deletion": "synthesis with an 11 nucleotide RNA removed 5? of its transcript. We tested was to tRNA primers being removed from cDNA by RNase H. Our analysis Tf1 cDNA extracted from virus-like particles revealed the surprising observation that the dominant", "change_char_case": " synthesis with an 11 nucleotide rNA removed From tHe 5? eNd oF iTs owN traNscript. We testeD WhetHer the self-primer of Tf1 waS simiLaR To tRna pRimerS in beinG ReMOVed FrOm The CDna bY RNasE H. OUr analySis of Tf1 cDNa exTrActed from virUS-lIke particlEs rEvealed the suRprIsing oBsErvATion tHat The doMinant", "whitespace_perturbation": " synthesis with an 11 nucl eotide RNA  remo ved  fr om  the  5?end of its own tran script. We tested whet her t he self - pr imerof Tf1w as s imi la rtotR N Aprime rsin bein g removedfro mthe cDNA byR Na se H. Ourana lysis of Tf1  cD NA ext ra cte d  from  vi rus-l ike pa r ticles  revealed  t h e surp r ising o b s er vati on that the domin a nt ", "underscore_trick": " synthesis_with an_11 nucleotide RNA removed_from the_5?_end of_its_own transcript. We_tested whether the_self-primer of Tf1 was_similar to tRNA_primers_in being removed from the cDNA by RNase H. Our analysis of Tf1 cDNA_extracted_from virus-like_particles_revealed_the surprising observation that the_dominant"}
{"text": " within the hippocampus and underscore the importance of CA2 in extrahippocampal oscillations. As increasing evidence is implicating area CA2 in several types of rodent social behavior, including aggression, these findings have relevance to human psychiatric disorders such as autism and schizophrenia that manifest with deficits in social cognition. Together with our studies", "synonym_substitution": "within the hippocampus and underscore the importance of CA2 in extrahippocampal oscillations. As increasing evidence is implicating sphere CA2 in respective type of rodent social behavior, including aggression, these finding have relevance to human psychiatric disorders such as autism and schizophrenia that attest with deficits in social cognition. Together with our studies", "butter_fingers": " wihhin the hippocampus and underscore the importence of CA2 in ebtrahippocampal oscillations. Aw inceeasing evidence is imolicating area CA2 in wwveral typxa of rodent skgial yeiavior, includinn aggressiot, these findincs hcve relevance to human psychiatric dysorderx duch as autism and fchiaophrenia that manifest with deficjts in vocial cognitoon. Together with our studles", "random_deletion": "within the hippocampus and underscore the importance in oscillations. As evidence is implicating of social behavior, including these findings have to human psychiatric disorders such as and schizophrenia that manifest with deficits in social cognition. Together with our studies", "change_char_case": " within the hippocampus and unDerscore thE impoRtaNce Of cA2 in ExtrAhippocampal osCIllaTions. As increasing evideNce is ImPLicaTInG area cA2 in sevERaL TYpeS oF rOdeNt SOcIal beHavIor, inclUding aggreSsiOn, These findingS HaVe relevancE to Human psychiaTriC disorDeRs sUCh as aUtiSm and SchizoPHrenia That manifEsT With deFIcits in SOCiAl coGnition. Together wiTH oUR studies", "whitespace_perturbation": " within the hippocampus an d undersco re th e i mpo rt ance  ofCA2 in extrahi p poca mpal oscillations. Asincre as i ng e v id enceis impl i ca t i ngar ea  CA 2i nsever altypes o f rodent s oci al  behavior, i n cl uding aggr ess ion, these f ind ings h av e r e levan ceto hu man ps y chiatr ic disord er s  sucha s autis m an d sc hizophrenia thatm an i fest with defi cits i ns oc i a l c ogn ition. Tog et her w i th ours tu d i e s", "underscore_trick": " within_the hippocampus_and underscore the importance_of CA2_in_extrahippocampal oscillations._As_increasing evidence is_implicating area CA2_in several types of_rodent social behavior,_including_aggression, these findings have relevance to human psychiatric disorders such as autism and schizophrenia_that_manifest with_deficits_in_social cognition. Together with our_studies"}
{"text": " unrelated Brazilian patients was found, suggesting a novel founder mutation in Brazil. Functional analyses indicated that the protein is expressed, but has no affinity to the IL-1 receptor and stimulation assay abnormalities are identical to those of the other DIRA patients As expected and similar to all other live children with DIRA, both patients", "synonym_substitution": "unrelated Brazilian patients was found, suggesting a novel laminitis mutant in Brazil. running analyses indicated that the protein is expressed, but has no affinity to the IL-1 sense organ and stimulation assay abnormalities are identical to those of the other DIRA patient As expected and similar to all early hot children with DIRA, both affected role", "butter_fingers": " ungelated Brazilian patienus was found, sugggsring a novel founder mutation in Brazil. Functionel abalystf indicated that tfe proteij is expeesstd, but has no affmhity to the IM-1 reczpvor and stimulajion assay atnormalities ase ibentical to those of the other DIRA [atientx Ws expected anq sikylar no all other live children with DIRA, bmth patients", "random_deletion": "unrelated Brazilian patients was found, suggesting a mutation Brazil. Functional indicated that the no to the IL-1 and stimulation assay are identical to those of the DIRA patients As expected and similar to all other live children with DIRA, patients", "change_char_case": " unrelated Brazilian patientS was found, sUggesTinG a nOvEl foUndeR mutation in BraZIl. FuNctional analyses indicaTed thAt THe prOTeIn is eXpresseD, BuT HAs nO aFfIniTy TO tHe IL-1 rEcePtor and StimulatioN asSaY abnormalitiES aRe identicaL to Those of the otHer dIRA paTiEntS as expEctEd and SimilaR To all oTher live cHiLDren wiTH DIRA, boTH PaTienTs", "whitespace_perturbation": " unrelated Brazilian patie nts was fo und,sug ges ti ng a  nov el founder mut a tion  in Brazil. Functional  anal ys e s in d ic atedthat th e  p r o tei nis  ex pr e ss ed, b uthas noaffinity t o t he  IL-1 recept o rand stimul ati on assay abn orm alitie sare ident ica l tothoseo f theother DIR Ap atient s  As exp e c te d an d similar to allo th e r live childre n with  D I RA , bot h p atients", "underscore_trick": " unrelated_Brazilian patients_was found, suggesting a_novel founder_mutation_in Brazil._Functional_analyses indicated that_the protein is_expressed, but has no_affinity to the_IL-1_receptor and stimulation assay abnormalities are identical to those of the other DIRA patients_As_expected and_similar_to_all other live children with_DIRA, both patients"}
{"text": " of non-specific effects on arousal, but it also tells us for the first time that different parts of the arousal circuitry, each of which depends on the NA channel, are differentially affected by these two agents. We previously reported that many mutations isolated on the basis of increased sensitivity to halothane have much smaller effects on", "synonym_substitution": "of non - specific effects on arousal, but it also tells us for the inaugural meter that different parts of the arousal circuitry, each of which count on the NA channel, are differentially affected by these two agent. We previously report that many mutations isolate on the basis of increased sensitivity to halothane get much smaller effects on", "butter_fingers": " of non-specific effects on xrousal, but it coso tenls us for the first time that different perts of tye arousal circuitry, exch of whpch depenes oi the NA channel, are difnzrentjwlly effected by thexe two agetts. We previouvlh xeported that many mutations isolateq on thr hasis of increwsed fensjniyity to halothane have much smalmer efftcts on", "random_deletion": "of non-specific effects on arousal, but it us the first that different parts of depends on the channel, are differentially by these two agents. We previously that many mutations isolated on the basis of increased sensitivity to halothane have smaller effects on", "change_char_case": " of non-specific effects on aroUsal, but it aLso teLls Us fOr The fIrst Time that differENt paRts of the arousal circuitRy, eacH oF WhicH DePends On the NA CHaNNEl, aRe DiFfeReNTiAlly aFfeCted by tHese two ageNts. we Previously rePOrTed that manY muTations isolaTed On the bAsIs oF IncreAseD sensItivitY To haloThane have MuCH smallER effectS ON", "whitespace_perturbation": " of non-specific effects o n arousal,  butitals otell s us  for the first time  that different partsof th ea rous a lcircu itry, e a ch o f w hi ch  de pe n ds  on t heNA chan nel, are d iff er entially aff e ct ed by thes e t wo agents. W e p reviou sl y r e porte d t hat m any mu t ations  isolated  o n  the b a sis ofi n cr ease d sensitivity toh al o thane have muc h smal le r  e f f ect s o n", "underscore_trick": " of_non-specific effects_on arousal, but it_also tells_us_for the_first_time that different_parts of the_arousal circuitry, each of_which depends on_the_NA channel, are differentially affected by these two agents. We previously reported that many_mutations_isolated on_the_basis_of increased sensitivity to halothane_have much smaller effects on"}
{"text": "-HE) in 29 children, 8 to 13 years who had overweight/obesity and LOC-eating. At post-treatment, children in FB-IPT reported greater decreases in depression (95% CI -7.23, -2.01, Cohen's d = 1.23) and anxiety (95", "synonym_substitution": "-HE) in 29 children, 8 to 13 years who had overweight / fleshiness and LOC - eating. At post - discussion, child in FB - IPT reported great decrease in depression (95% CI -7.23, -2.01, Cohen's d = 1.23) and anxiety (95", "butter_fingers": "-HE) ln 29 children, 8 to 13 years dho had overweiyyt/obesmty and LOC-eativg. At post-treatment, children ib FB-IKN reported greater dezreases ij depreswion (95% CI -7.23, -2.01, Cohei'a d = 1.23) akb anxjcty (95", "random_deletion": "-HE) in 29 children, 8 to 13 had and LOC-eating. post-treatment, children in depression CI -7.23, -2.01, d = 1.23) anxiety (95", "change_char_case": "-HE) in 29 children, 8 to 13 years who had Overweight/ObesiTy aNd LoC-EatiNg. At Post-treatment, cHIldrEn in FB-IPT reported greatEr decReASes iN DePressIon (95% CI -7.23, -2.01, CoHEn'S D = 1.23) And AnXiEty (95", "whitespace_perturbation": "-HE) in 29 children, 8 to13 years w ho ha d o ver we ight /obe sity and LOC-e a ting . At post-treatment, c hildr en in F B -I PT re portedg re a t erde cr eas es in  depr ess ion (95 % CI -7.23 , - 2. 01, Cohen'sd  =  1.23) and  an xiety (95", "underscore_trick": "-HE) in_29 children,_8 to 13 years_who had_overweight/obesity_and LOC-eating._At_post-treatment, children in_FB-IPT reported greater_decreases in depression (95%_CI -7.23, -2.01,_Cohen's_d = 1.23) and anxiety (95"}
{"text": ", an expedient designed to preclude any possibility of introduction of the polybasic site into circulating viruses by genetic exchange, resulted in improved immunogenicity and protective efficacy in this small study. In addition, immunization with NDV expressing the other major HPAIV surface antigen, the neuraminidase (NA) protein, also was", "synonym_substitution": ", an expedient designed to preclude any possibility of introduction of the polybasic web site into circulate viruses by genetic substitution, leave in improved immunogenicity and protective efficacy in this small sketch. In summation, immunization with NDV expressing the early major HPAIV open antigen, the neuraminidase (NA) protein, also was", "butter_fingers": ", an expedient designed to pveclude any possnvility of infroductiun of the polybasic site intl xircuoating viruses by genegic exchajge, resuoted un improvev immunonznicifn and 'rotective effigacy in thiv small study. Hn abdition, immunization with NDV expresfing thr lther major HPWIV xtrfadv cntigen, the neuraminidase (NA) prktein, anso was", "random_deletion": ", an expedient designed to preclude any introduction the polybasic into circulating viruses improved and protective efficacy this small study. addition, immunization with NDV expressing the major HPAIV surface antigen, the neuraminidase (NA) protein, also was", "change_char_case": ", an expedient designed to precLude any posSibilIty Of iNtRoduCtioN of the polybasiC Site Into circulating viruses By genEtIC excHAnGe, resUlted in IMpROVed ImMuNogEnICiTy and ProTective Efficacy in ThiS sMall study. In aDDiTion, immuniZatIon with NDV exPreSsing tHe OthER majoR HPaIV suRface aNTigen, tHe neuramiNiDAse (NA) pROtein, alSO WaS", "whitespace_perturbation": ", an expedient designed to  precludeany p oss ibi li ty o f in troduction oft he p olybasic site into cir culat in g  vir u se s bygenetic ex c h ang e,  r esu lt e din im pro ved imm unogenicit y a nd  protectivee ff icacy in t his  small study . I n addi ti on, immun iza tionwith N D V expr essing th eo ther m a jor HPA I V  s urfa ce antigen, the n e ur a minidase (NA)protei n, al s o  wa s", "underscore_trick": ", an_expedient designed_to preclude any possibility_of introduction_of_the polybasic_site_into circulating viruses_by genetic exchange,_resulted in improved immunogenicity_and protective efficacy_in_this small study. In addition, immunization with NDV expressing the other major HPAIV surface_antigen,_the neuraminidase_(NA)_protein,_also was"}
{"text": "brain-dorsolateral prefrontal interactions during selective updating between subjects rated as low and high-performers. The midbrain engaged the DLPFC during updating to a greater degree in low performers vs. high performers. These findings of meso-cortico-striatal network engagement during updating supports the notion of dopaminergic", "synonym_substitution": "brain - dorsolateral prefrontal interactions during selective updating between subjects rated as depleted and eminent - performers. The midbrain engaged the DLPFC during updating to a great degree in low performer vs. high performers. These findings of meso - cortico - striatal net betrothal during updating support the notion of dopaminergic", "butter_fingers": "braln-dorsolateral prefrontau interactions byring velectjve updaging between subjects rated es liw ane high-performers. The mkdbrain ejgaged tye DOPFC during updatinn to z grectxr degree in loe performess vs. high perxofmzrs. These findings of meso-cortico-stryatal nrtaork engagemenj durpnd upsating supports the notion of dopajinergib", "random_deletion": "brain-dorsolateral prefrontal interactions during selective updating between as and high-performers. midbrain engaged the greater in low performers high performers. These of meso-cortico-striatal network engagement during updating the notion of dopaminergic", "change_char_case": "brain-dorsolateral prefrontAl interactIons dUriNg sElEctiVe upDating between sUBjecTs rated as low and high-perFormeRs. tHe miDBrAin enGaged thE dLpfc duRiNg UpdAtINg To a grEatEr degreE in low perfOrmErS vs. high perfoRMeRs. These finDinGs of meso-cortIco-StriatAl NetWOrk enGagEment During UPdatinG supports ThE Notion OF dopamiNERgIc", "whitespace_perturbation": "brain-dorsolateral prefron tal intera ction s d uri ng  sel ecti ve updating be t ween  subjects rated as low  andhi g h-pe r fo rmers . The m i db r a inen ga ged  t h eDLPFC  du ring up dating toa g re ater degreei nlow perfor mer s vs. high p erf ormers .The s e fin din gs of  meso- c ortico -striatal  n e tworke ngageme n t  d urin g updating suppor t st he notion of d opamin er g ic ", "underscore_trick": "brain-dorsolateral prefrontal_interactions during_selective updating between subjects_rated as_low_and high-performers._The_midbrain engaged the_DLPFC during updating_to a greater degree_in low performers_vs._high performers. These findings of meso-cortico-striatal network engagement during updating supports the notion of_dopaminergic"}
{"text": " These data indicate that Atf1p is responsible for targeting Tf1 to specific insertion sites in the fbp1 promoter. Aim 1 Dozens of proteins control the docking and fusion of exocytic vesicles in neurons and endocrine cells. The identity and roles of many of these proteins have been assigned through a combination of genetics", "synonym_substitution": "These data indicate that Atf1p is responsible for targeting Tf1 to specific interpolation web site in the fbp1 promoter. Aim 1 tons of protein control the docking and fusion of exocytic vesicles in nerve cell and endocrine gland cells. The identity and function of many of these proteins have been assigned through a combination of genetics", "butter_fingers": " Thfse data indicate that Auf1p is responsiblg dor tacgeting Tf1 to soecific insertion sites in tie fvp1 primoter. Aim 1 Dozens of oroteins bontrol tye dixking and hhsion on exodntic rewicles in neurpns and engocrine cells. Dhd ndentity and roles of many of these [roteinx jave been assidned ehrohgh a combination of genetics", "random_deletion": "These data indicate that Atf1p is responsible Tf1 specific insertion in the fbp1 proteins the docking and of exocytic vesicles neurons and endocrine cells. The identity roles of many of these proteins have been assigned through a combination of", "change_char_case": " These data indicate that Atf1p Is responsiBle foR taRgeTiNg Tf1 To spEcific insertioN SiteS in the fbp1 promoter. Aim 1 DoZens oF pROteiNS cOntroL the docKInG ANd fUsIoN of ExOCyTic veSicLes in neUrons and enDocRiNe cells. The idENtIty and roleS of Many of these pRotEins haVe BeeN AssigNed ThrouGh a comBInatioN of genetiCs", "whitespace_perturbation": " These data indicate thatAtf1p is r espon sib lefo r ta rget ing Tf1 to spe c ific  insertion sites in th e fbp 1p romo t er . Aim  1 Doze n so f  pr ot ei nsco n tr ol th e d ockingand fusion  of  e xocytic vesi c le s in neuro nsand endocrin e c ells.Th e i d entit y a nd ro les of many o f these p ro t eins h a ve been a ss igne d through a combi n at i on of genetics ", "underscore_trick": " These_data indicate_that Atf1p is responsible_for targeting_Tf1_to specific_insertion_sites in the_fbp1 promoter. Aim_1 Dozens of proteins_control the docking_and_fusion of exocytic vesicles in neurons and endocrine cells. The identity and roles of_many_of these_proteins_have_been assigned through a combination_of genetics"}
{"text": " therefore recorded neuronal activity of CA2 neurons in vivo in rats during exploration and social interactions and found that CA2 neurons are uniquely sensitive to changes in social context and other situations involving novelty, suggesting that neurons in this area may be providing downstream regions with information relevant to changes in context. We next sought to determine how CA2", "synonym_substitution": "therefore recorded neuronal activity of CA2 nerve cell in vivo in rotter during exploration and social interactions and found that CA2 nerve cell are uniquely sensitive to change in social context and other situations involve novelty, suggesting that nerve cell in this sphere may be providing downstream regions with data relevant to changes in context. We next sought to decide how CA2", "butter_fingers": " thfrefore recorded neuronau activity of CC2 neurois in vjvo in rxts during exploration and slcual ibteractions and found ghat CA2 nvurons arw unmquely sensitive to channzs in docicl context and ojher situatimns involving toxepty, suggesting that neurons in this area msy be providing qownxereaj regions with information relevanf to chenges in contexy. We next sought to determlne jow CA2", "random_deletion": "therefore recorded neuronal activity of CA2 neurons in during exploration social interactions and uniquely to changes in context and other involving novelty, suggesting that neurons in area may be providing downstream regions with information relevant to changes in context. next sought to determine how CA2", "change_char_case": " therefore recorded neuronal Activity of cA2 neuRonS in ViVo in Rats During exploratIOn anD social interactions and Found ThAT CA2 nEUrOns arE uniqueLY sENSitIvE tO chAnGEs In socIal Context And other siTuaTiOns involving NOvElty, suggesTinG that neurons In tHis areA mAy bE ProviDinG downStream REgions With inforMaTIon relEVant to cHANgEs in Context. We next sougHT tO Determine how CA2", "whitespace_perturbation": " therefore recorded neuron al activit y ofCA2  ne ur onsin v ivo in rats du r ingexploration and social  inte ra c tion s  a nd fo und tha t  C A 2  ne ur on s a re un iquel y s ensitiv e to chang esin  social cont e xt  and other  si tuations inv olv ing no ve lty ,  sugg est ing t hat ne u rons i n this ar ea may be providi n g  d owns tream regions wit h  i n formation rele vant t oc ha n g esincontext. W enexts ought t o  d e t e rmi n e how CA2", "underscore_trick": " therefore_recorded neuronal_activity of CA2 neurons_in vivo_in_rats during_exploration_and social interactions_and found that_CA2 neurons are uniquely_sensitive to changes_in_social context and other situations involving novelty, suggesting that neurons in this area may_be_providing downstream_regions_with_information relevant to changes in_context. We next sought to_determine how_CA2"}
{"text": " adequately understand the cognitive transfer effects of the training interventions, a longer followup period is required, particularly to see whether there is a separation of the change trajectories for everyday activities of trained and untrained participants over time. Phase II of ACTIVE is proposed as a followup study focused on measuring the long-term impact of", "synonym_substitution": "adequately understand the cognitive transfer effects of the training interposition, a farseeing followup period is command, peculiarly to see whether there is a separation of the variety trajectory for everyday activities of trained and untrained participants over time. Phase II of ACTIVE is nominate as a followup study concenter on measuring the long - term impact of", "butter_fingers": " adfquately understand the gognitive transfgr effecvs of tge trainkng interventions, a longer flloowup period is required, pafticularlj to see qhetier there is a sxlaratiok of fme chcnje trajectories for everygay activities ow crained and untrained participants oder timr. Ohase II of ACJIVE ps prolosed as a followup study focused kn measlring the long-terk impact of", "random_deletion": "adequately understand the cognitive transfer effects of interventions, longer followup is required, particularly a of the change for everyday activities trained and untrained participants over time. II of ACTIVE is proposed as a followup study focused on measuring the impact of", "change_char_case": " adequately understand the coGnitive traNsfer EffEctS oF the TraiNing interventiONs, a lOnger followup period is rEquirEd, PArtiCUlArly tO see wheTHeR THerE iS a SepArATiOn of tHe cHange trAjectories For EvEryday activiTIeS of trained And Untrained parTicIpants OvEr tIMe. PhaSe Ii of ACtIVE is PRoposeD as a folloWuP Study fOCused on MEAsUrinG the long-term impacT Of", "whitespace_perturbation": " adequately understand the  cognitive  tran sfe r e ff ects  ofthe training i n terv entions, a longer foll owuppe r iodi srequi red, pa r ti c u lar ly  t o s ee wh ether  th ere isa separati onof  the changet ra jectoriesfor  everyday ac tiv itiesof  tr a inedand  untr ainedp artici pants ove rt ime. P h ase IIo f  A CTIV E is proposed asa  f o llowup study f ocused  o n  m e a sur ing  the long- te rm im p act of", "underscore_trick": " adequately_understand the_cognitive transfer effects of_the training_interventions,_a longer_followup_period is required,_particularly to see_whether there is a_separation of the_change_trajectories for everyday activities of trained and untrained participants over time. Phase II of_ACTIVE_is proposed_as_a_followup study focused on measuring_the long-term impact of"}
{"text": " humans, but IT administration would not. We evaluated IN administration of the NDV construct expressing the SARS S protein and found it was not very immunogenic or protective, presumably because of insufficient vector replication in the nasal passages. Whether or not this will be predictive of replicative capability and immunogenicity in humans is unclear and can", "synonym_substitution": "humans, but IT administration would not. We evaluated IN administration of the NDV manufacture carry the SARS S protein and found it was not very immunogenic or protective, presumably because of insufficient vector replication in the nasal passage. Whether or not this will be predictive of replicative capability and immunogenicity in humans is unclear and can", "butter_fingers": " hulans, but IT administratiun would not. We evaluaved IN zdministfation of the NDV construct xxprwssint the SARS S protein avd found pt was nor vecy immunogenic oc protecbnve, pdcsumaylb because of inxufficient vector replicdtkou in the nasal passages. Whether or njt this wlll be predictyve ps rellicative capability and immunogenjcity ii humans is unckear and can", "random_deletion": "humans, but IT administration would not. We administration the NDV expressing the SARS was very immunogenic or presumably because of vector replication in the nasal passages. or not this will be predictive of replicative capability and immunogenicity in humans unclear and can", "change_char_case": " humans, but IT administration Would not. We EvaluAteD IN AdMiniStraTion of the NDV coNStruCt expressing the SARS S prOtein AnD FounD It Was noT very imMUnOGEniC oR pRotEcTIvE, presUmaBly becaUse of insufFicIeNt vector replICaTion in the nAsaL passages. WheTheR or not ThIs wILl be pRedIctivE of repLIcativE capabiliTy ANd immuNOgeniciTY In HumaNs is unclear and can", "whitespace_perturbation": " humans, but IT administra tion would  not.  We  ev al uate d IN  administratio n  ofthe NDV construct expr essin gt he S A RS  S pr otein a n df o und  i twas  n o tveryimm unogeni c or prote cti ve , presumably be cause of i nsu fficient vec tor  repli ca tio n  in t henasal  passa g es. Wh ether orno t  thisw ill bep r ed icti ve of replicative ca p ability and im munoge ni c it y inhum ans is unc le ar an d  can", "underscore_trick": " humans,_but IT_administration would not. We_evaluated IN_administration_of the_NDV_construct expressing the_SARS S protein_and found it was_not very immunogenic_or_protective, presumably because of insufficient vector replication in the nasal passages. Whether or not_this_will be_predictive_of_replicative capability and immunogenicity in_humans is unclear and can"}
{"text": " required for efficient integration. We asked whether promoter activity was required for integration by measuring transcript levels of ade6. Deletions of sequence on either side of the 160 nt region caused five to ten-fold reductions in ade6 mRNA. Nevertheless, the deletions caused no reduction in integration efficiency. These results indicated that", "synonym_substitution": "required for efficient integration. We asked whether showman natural process was required for integration by measure transcript grade of ade6. Deletions of sequence on either english of the 160 national trust region caused five to ten - fold reductions in ade6 mRNA. Nevertheless, the deletions induce no reduction in integration efficiency. These solution argue that", "butter_fingers": " reeuired for efficient inttgration. We asked whethec promofer actixity was required for integretiob by neasuring transcript ldvels of wde6. Delerionw of sequenrs on eibker sjfe oy vhe 160 nt region gaused five to ten-fold reguztnons in ade6 mRNA. Nevertheless, the dejetions cwused no reducjion pn intsgration efficiency. These results jndicattd that", "random_deletion": "required for efficient integration. We asked whether was for integration measuring transcript levels on side of the nt region caused to ten-fold reductions in ade6 mRNA. the deletions caused no reduction in integration efficiency. These results indicated that", "change_char_case": " required for efficient integRation. We asKed whEthEr pRoMoteR actIvity was requirED for Integration by measuring TransCrIPt leVElS of adE6. DeletiONs OF SeqUeNcE on EiTHeR side Of tHe 160 nt regIon caused fIve To Ten-fold reducTIoNs in ade6 mRNa. NeVertheless, thE deLetionS cAusED no reDucTion iN integRAtion eFficiency. thESe resuLTs indicATEd That", "whitespace_perturbation": " required for efficient in tegration.  We a ske d w he ther  pro moter activity wasrequired for integrati on by  m e asur i ng  tran scriptl ev e l s o fad e6.  D e le tions  of  sequen ce on eith ersi de of the 16 0  n t region c aus ed five to t en- fold r ed uct i ons i n a de6 m RNA. N e verthe less, the  d e letion s  caused n oredu ction in integrat i on efficiency. Th ese re su l ts i ndi cat ed that", "underscore_trick": " required_for efficient_integration. We asked whether_promoter activity_was_required for_integration_by measuring transcript_levels of ade6._Deletions of sequence on_either side of_the_160 nt region caused five to ten-fold reductions in ade6 mRNA. Nevertheless, the deletions_caused_no reduction_in_integration_efficiency. These results indicated that"}
{"text": " gene approaches have not been successful in identifying the molecular basis of this disorder. Thus, an unbiased approach to gene discovery seems more likely to achieve the goal of identifying novel candidate genes responsible for premature GnRH secretion in CPP. We have established collaborations with investigators both locally and internationally to increase recruitment of families with idiopathic C", "synonym_substitution": "gene approaches have not been successful in identifying the molecular basis of this disorder. therefore, an indifferent access to gene discovery seems more likely to achieve the finish of identifying novel candidate gene creditworthy for premature GnRH secretion in CPP. We have established collaborations with investigators both locally and internationally to increase recruitment of families with idiopathic vitamin c", "butter_fingers": " geje approaches have not bten successful in identihying tge molecjlar basis of this disorder. Vhus, an ubbiased approach to geve discovvry seems mort likely to achiets the goal of ldentnfbing novel candldate genes responsible fmr pxemature GnRH secretion in CPP. We hade estanllshed collaborwtiomf wifh investigators both locally and jnternauionally to increaxe recruitment of families witj idiopathic C", "random_deletion": "gene approaches have not been successful in molecular of this Thus, an unbiased more to achieve the of identifying novel genes responsible for premature GnRH secretion CPP. We have established collaborations with investigators both locally and internationally to increase of families with idiopathic C", "change_char_case": " gene approaches have not been Successful In ideNtiFyiNg The mOlecUlar basis of thiS DisoRder. Thus, an unbiased apprOach tO gENe diSCoVery sEems morE LiKELy tO aChIevE tHE gOal of IdeNtifyinG novel candIdaTe Genes responsIBlE for prematUre gnRH secretioN in cPP. We hAvE esTAblisHed CollaBoratiONs with InvestigaToRS both lOCally anD INtErnaTionally to increasE ReCRuitment of famiLies wiTh IDiOPAthIc C", "whitespace_perturbation": " gene approaches have notbeen succe ssful  in  id en tify ingthe molecularb asis  of this disorder. Thu s, an  u n bias e dappro ach tog en e dis co ve ryse e ms  more  li kely to  achieve t hego al of identi f yi ng novel c and idate genesres ponsib le  fo r  prem atu re Gn RH sec r etionin CPP. W eh ave es t ablishe d co llab orations with inv e st i gators both lo callyan d  i n t ern ati onally toin creas e  recrui t me n t off amilies withidiopathicC ", "underscore_trick": " gene_approaches have_not been successful in_identifying the_molecular_basis of_this_disorder. Thus, an_unbiased approach to_gene discovery seems more_likely to achieve_the_goal of identifying novel candidate genes responsible for premature GnRH secretion in CPP. We_have_established collaborations_with_investigators_both locally and internationally to_increase recruitment of families with_idiopathic C"}
{"text": "VAR2CSA antibodies in this functional assay. Our second major area of investigation relates to the identification of malaria parasite-encoded antigens which could be the targets of new vaccines or drugs. We have hypothesized that there are conserved epitopes present on the infected red cell which could represent such targets. While most blood-stage vaccine candidates", "synonym_substitution": "VAR2CSA antibodies in this functional assay. Our second major area of investigation relates to the designation of malaria leech - encoded antigens which could be the target of raw vaccines or drugs. We have speculate that there are conserved epitopes present on the septic crimson cell which could defend such targets. While most blood - degree vaccine campaigner", "butter_fingers": "VAR2FSA antibodies in this fmnctional assay. Our secmnd manor area of investigation relates to tye idtutification of malarka parasine-encoded antmgens which coulv be the targefd of iew vaccines or drugs. We vave hypothesisea chat there are conserved epitopes prqsent om hhe infected rgd cekj whjbh could represent such targets. While kost blood-stabe vaccine candidates", "random_deletion": "VAR2CSA antibodies in this functional assay. Our area investigation relates the identification of be targets of new or drugs. We hypothesized that there are conserved epitopes on the infected red cell which could represent such targets. While most blood-stage candidates", "change_char_case": "VAR2CSA antibodies in this funCtional assAy. Our SecOnd MaJor aRea oF investigation RElatEs to the identification oF malaRiA ParaSItE-encoDed antiGEnS WHicH cOuLd bE tHE tArgetS of New vaccInes or drugS. We HaVe hypothesizED tHat there arE coNserved epitoPes PresenT oN thE InfecTed Red ceLl whicH Could rEpresent sUcH TargetS. while moST BlOod-sTage vaccine candidATeS", "whitespace_perturbation": "VAR2CSA antibodies in this  functiona l ass ay.  Ou rseco nd m ajor area of i n vest igation relates to the  iden ti f icat i on  of m alariap ar a s ite -e nc ode da nt igens  wh ich cou ld be thetar ge ts of new va c ci nes or dru gs.  We have hyp oth esized  t hat there  ar e con served epitop es presen to n thei nfected r ed  cel l which could rep r es e nt such target s. Whi le mo s t  bl ood -stage vac ci ne ca n didates ", "underscore_trick": "VAR2CSA antibodies_in this_functional assay. Our second_major area_of_investigation relates_to_the identification of_malaria parasite-encoded antigens_which could be the_targets of new_vaccines_or drugs. We have hypothesized that there are conserved epitopes present on the infected_red_cell which_could_represent_such targets. While most blood-stage_vaccine candidates"}
{"text": " functioning. The ACTIVE study will determine if cognitive training can help older adults to continue functioning and living independently for a longer period of time. The ACTIVE study will determine if cognitive training can help older adults to continue functioning and living independently for a longer period of time. [unreadable] [unreadable] This application is a", "synonym_substitution": "functioning. The ACTIVE study will determine if cognitive training can avail previous adults to continue functioning and live independently for a longer period of prison term. The ACTIVE sketch will determine if cognitive education can avail older adult to continue functioning and know independently for a long period of time. [ unreadable ] [ unreadable ] This application is a", "butter_fingers": " fujctioning. The ACTIVE stuay will determiuw if cmgnitibe trainkng can help older adults to cintinye functioning and livkng indepvndently dor e longer period of time. Bke ACFLVE scuvy will determike if cognidive training wav kelp older adults to continue functijning amd living indepegdenuly for a longer period of time. [unreadabls] [unreavable] This applocation is a", "random_deletion": "functioning. The ACTIVE study will determine if can older adults continue functioning and period time. The ACTIVE will determine if training can help older adults to functioning and living independently for a longer period of time. [unreadable] [unreadable] This is a", "change_char_case": " functioning. The ACTIVE study Will determIne if CogNitIvE traIninG can help older aDUlts To continue functioning aNd livInG IndePEnDentlY for a loNGeR PEriOd Of TimE. THE AcTIVE StuDy will dEtermine if CogNiTive training CAn Help older aDulTs to continue FunCtioniNg And LIving IndEpendEntly fOR a longEr period oF tIMe. [unreADable] [unREAdAble] this application is A", "whitespace_perturbation": " functioning. The ACTIVE s tudy willdeter min e i fcogn itiv e training can help  older adults to conti nue f un c tion i ng  andlivingi nd e p end en tl y f or alonge r p eriod o f time. Th e A CT IVE study wi l ldetermineifcognitive tr ain ing ca nhel p  olde r a dults  to co n tinuefunctioni ng and li v ing ind e p en dent ly for a longer p e ri o d of time. [un readab le ]  [ u n rea dab le] This a pp licat i on is a ", "underscore_trick": " functioning._The ACTIVE_study will determine if_cognitive training_can_help older_adults_to continue functioning_and living independently_for a longer period_of time. The_ACTIVE_study will determine if cognitive training can help older adults to continue functioning and_living_independently for_a_longer_period of time. [unreadable] [unreadable]_This application is a"}
{"text": " host immune system. We have continued to collaborate with Dr. Rick Fairhurst (LMVR) and Dr. Mahamadou Diakite (MRTC) on a 4-year longitudinal study of 1400 children in 3 villages in Mali. In 2009 we identified a sub-cohort of these children, selecting", "synonym_substitution": "host immune system. We have continued to collaborate with Dr. Rick Fairhurst (LMVR) and Dr. Mahamadou Diakite (MRTC) on a 4 - year longitudinal discipline of 1400 child in 3 villages in Mali. In 2009 we identified a sub - age group of these children, selecting", "butter_fingers": " hodt immune system. We have continued to collaborete witg Dr. Ricy Fairhurst (LMVR) and Dr. Mahalaeou Duakite (MRTC) on a 4-year uongitudijal studt of 1400 children mh 3 villages ih Maln. Mn 2009 we identifigd a sub-cohost of these chhlarzn, selecting", "random_deletion": "host immune system. We have continued to Dr. Fairhurst (LMVR) Dr. Mahamadou Diakite study 1400 children in villages in Mali. 2009 we identified a sub-cohort of children, selecting", "change_char_case": " host immune system. We have conTinued to coLlaboRatE wiTh dr. RiCk FaIrhurst (LMVR) and dR. MahAmadou Diakite (MRTC) on a 4-yeAr lonGiTUdinAL sTudy oF 1400 childrEN iN 3 VIllAgEs In MAlI. in 2009 We ideNtiFied a suB-cohort of tHesE cHildren, selecTInG", "whitespace_perturbation": " host immune system. We ha ve continu ed to  co lla bo rate  wit h Dr. Rick Fai r hurs t (LMVR) and Dr. Maham adouDi a kite (M RTC)on a 4- y ea r lon gi tu din al st udy o f 1 400 chi ldren in 3  vi ll ages in Mali .  I n 2009 weide ntified a su b-c ohortof  th e se ch ild ren,select i ng", "underscore_trick": " host_immune system._We have continued to_collaborate with_Dr._Rick Fairhurst_(LMVR)_and Dr. Mahamadou_Diakite (MRTC) on_a 4-year longitudinal study_of 1400 children_in_3 villages in Mali. In 2009 we identified a sub-cohort of these children, selecting"}
{"text": " their similarity to retroviruses, LTR-retrotransposons are important models for retrovirus replication. The retrotransposon under study in our laboratory is the Tf1 element of the fission yeast Schizosaccharomyces pombe. During the synthesis of cDNA, reverse transcriptase (RT) generates a", "synonym_substitution": "their similarity to retroviruses, LTR - retrotransposons are important models for retrovirus replication. The retrotransposon under discipline in our lab is the Tf1 element of the fission yeast Schizosaccharomyces pombe. During the synthesis of cDNA, reverse transcriptase (RT) render a", "butter_fingers": " thfir similarity to retrovlruses, LTR-retrottabsposois are jmportang models for retrovirus replmcatuon. Tye retrotransposon unddr study pn our lavorauory is the Tf1 elxjent of the fjdsiou beast Schizosacgharomyces [ombe. During tve svnthesis of cDNA, reverse transcriptafe (RT) grnfrates a", "random_deletion": "their similarity to retroviruses, LTR-retrotransposons are important retrovirus The retrotransposon study in our of fission yeast Schizosaccharomyces During the synthesis cDNA, reverse transcriptase (RT) generates a", "change_char_case": " their similarity to retrovirUses, LTR-retRotraNspOsoNs Are iMporTant models for rETrovIrus replication. The retrOtranSpOSon uNDeR studY in our lABoRATorY iS tHe TF1 eLEmEnt of The Fission Yeast SchizOsaCcHaromyces pomBE. DUring the syNthEsis of cDNA, reVerSe tranScRipTAse (RT) GenErateS a", "whitespace_perturbation": " their similarity to retro viruses, L TR-re tro tra ns poso ns a re important m o dels  for retrovirus replic ation .T he r e tr otran sposonu nd e r  st ud yinou r  l abora tor y is th e Tf1 elem ent  o f the fissio n  y east Schiz osa ccharomycespom be. Du ri ngt he sy nth esisof cDN A , reve rse trans cr i ptase( RT) gen e r at es a ", "underscore_trick": " their_similarity to_retroviruses, LTR-retrotransposons are important_models for_retrovirus_replication. The_retrotransposon_under study in_our laboratory is_the Tf1 element of_the fission yeast_Schizosaccharomyces_pombe. During the synthesis of cDNA, reverse transcriptase (RT) generates a"}
{"text": " modified by early-life enrichment. Because PNNs had been previously implicated in limiting synaptic plasticity late in postnatal development, effectively ending critical periods for plasticity, we tested whether PNNs also play an important role in restricting synaptic potentiation of the normally plasticity-resistant excitatory CA2 synapses. We found that treatment of hippocampal", "synonym_substitution": "modified by early - life enrichment. Because PNNs had been previously implicated in limiting synaptic malleability deep in postnatal development, effectively end critical period for plasticity, we tested whether PNNs besides play an important role in restrict synaptic potentiation of the normally plasticity - resistant excitatory CA2 synapsis. We found that treatment of hippocampal", "butter_fingers": " mofified by early-life enrighment. Because PUBs had been lreviousuy implicated in limiting syiaptuc plqsticity late in postnxtal devepopment, wffertively ending ccjtical izrioda for 'lasticity, we tgsted whethes PNNs also pldy au important role in restricting syna[tic poyejtiation of thg norkwlly ilcsticity-resistant excitatory CA2 synapsts. We found that tteatment of hippocampal", "random_deletion": "modified by early-life enrichment. Because PNNs had implicated limiting synaptic late in postnatal for we tested whether also play an role in restricting synaptic potentiation of normally plasticity-resistant excitatory CA2 synapses. We found that treatment of hippocampal", "change_char_case": " modified by early-life enrichMent. BecausE PNNs Had BeeN pReviOuslY implicated in lIMitiNg synaptic plasticity laTe in pOsTNataL DeVelopMent, effECtIVEly EnDiNg cRiTIcAl perIodS for plaSticity, we tEstEd Whether PNNs aLSo Play an impoRtaNt role in restRicTing syNaPtiC PotenTiaTion oF the noRMally pLasticity-ReSIstant EXcitatoRY cA2 SynaPses. We found that trEAtMEnt of hippocampAl", "whitespace_perturbation": " modified by early-life en richment.Becau sePNN shadbeen  previously im p lica ted in limiting synapt ic pl as t icit y  l ate i n postn a ta l dev el op men t, ef fecti vel y endin g critical  pe ri ods for plas t ic ity, we te ste d whether PN Nsalso p la y a n  impo rta nt ro le inr estric ting syna pt i c pote n tiation o fthenormally plastici t y- r esistant excit atoryCA 2  s y n aps es.  We foundth at tr e atmento fh i p poc a mpal", "underscore_trick": " modified_by early-life_enrichment. Because PNNs had_been previously_implicated_in limiting_synaptic_plasticity late in_postnatal development, effectively_ending critical periods for_plasticity, we tested_whether_PNNs also play an important role in restricting synaptic potentiation of the normally plasticity-resistant_excitatory_CA2 synapses._We_found_that treatment of hippocampal"}
{"text": "2'-methylidene-cyclopentyl]-1H-purin-6-one (CMCP). It is of note that CMCP structurally resembles CdG in that both compounds have 4'-cyano moiety and also resembles ETV in that both of CMCP and ETV have an exocyclic double", "synonym_substitution": "2'-methylidene - cyclopentyl]-1H - purin-6 - one (CMCP). It is of note that CMCP structurally resembles CdG in that both compounds have 4'-cyano moiety and besides resemble ETV in that both of CMCP and ETV receive an exocyclic double", "butter_fingers": "2'-metjylidene-cyclopentyl]-1H-purik-6-one (CMCP). It is of note that DMCP strjcturally resembles CdG in tiat voth xompounds have 4'-cyano muiety and also rewembows ETV in vgat botm of DLCP cnv ETV have an ewocyclic dogble", "random_deletion": "2'-methylidene-cyclopentyl]-1H-purin-6-one (CMCP). It is of note that resembles in that compounds have 4'-cyano in both of CMCP ETV have an double", "change_char_case": "2'-methylidene-cyclopentyl]-1H-puRin-6-one (CMCP). it is oF noTe tHaT CMCp strUcturally resemBLes CDG in that both compounds hAve 4'-cyAnO MoieTY aNd alsO resembLEs etv in ThAt BotH oF cMcP and eTV Have an eXocyclic doUblE", "whitespace_perturbation": "2'-methylidene-cyclopentyl ]-1H-purin -6-on e ( CMC P) . It  isof note that C M CP s tructurally resemblesCdG i nt hatb ot h com poundsh av e 4'- cy an o m oi e ty  andals o resem bles ETV i n t ha t both of CM C Pand ETV ha vean exocyclic  do uble", "underscore_trick": "2'-methylidene-cyclopentyl]-1H-purin-6-one (CMCP)._It is_of note that CMCP_structurally resembles_CdG_in that_both_compounds have 4'-cyano_moiety and also_resembles ETV in that_both of CMCP_and_ETV have an exocyclic double"}
{"text": " A randomized clinical trial to study the effects on insulin resistance of preventing depression in obese adolescents with a family history of type 2 diabetes (14,15) found at one-year follow-up, among girls with moderate baseline depressive symptoms (N = 78), those given a cognitive behavioral therapy (CBT) program for prevention", "synonym_substitution": "A randomized clinical trial to study the effects on insulin underground of prevent depression in obese adolescents with a kin history of type 2 diabetes (14,15) found at one - class follow - up, among girls with moderate baseline depressive symptoms (N = 78), those contribute a cognitive behavioral therapy (CBT) program for prevention", "butter_fingers": " A gandomized clinical triau to study the gfdects mn inshlin reskstance of preventing depresdiin in obese adolescents witf a familj history of uype 2 diabetes (14,15) found at one-yead folniw-up, among girks with mogerate baselina ae'ressive symptoms (N = 78), those given a sognitife behavioral thgrapy (SBT) lgonram for prevention", "random_deletion": "A randomized clinical trial to study the insulin of preventing in obese adolescents type diabetes (14,15) found one-year follow-up, among with moderate baseline depressive symptoms (N 78), those given a cognitive behavioral therapy (CBT) program for prevention", "change_char_case": " A randomized clinical trial tO study the eFfectS on InsUlIn reSistAnce of preventiNG depRession in obese adolesceNts wiTh A FamiLY hIstorY of type 2 DIaBETes (14,15) FoUnD at OnE-YeAr folLow-Up, among Girls with mOdeRaTe baseline dePReSsive symptOms (n = 78), those given a CogNitive BeHavIOral tHerApy (CBt) progrAM for prEvention", "whitespace_perturbation": " A randomized clinical tri al to stud y the  ef fec ts  oninsu lin resistance of p reventing depression i n obe se adol e sc entswith af am i l y h is to ryof ty pe 2dia betes ( 14,15) fou ndat  one-year fo l lo w-up, amon g g irls with mo der ate ba se lin e  depr ess ive s ymptom s  (N =78), thos eg iven a cogniti v e  b ehav ioral therapy (CB T )p rogram for pre ventio n", "underscore_trick": " A_randomized clinical_trial to study the_effects on_insulin_resistance of_preventing_depression in obese_adolescents with a_family history of type_2 diabetes (14,15)_found_at one-year follow-up, among girls with moderate baseline depressive symptoms (N = 78), those_given_a cognitive_behavioral_therapy_(CBT) program for prevention"}
{"text": " a) we identified the structural requirements of chemokine receptors for the biological function and HIV usage (J Biol Chem. 276, 40133, 2001);b) investigated how naturally occurring CCR5 mutants impaired for surface expression impact the physiological function of the wt receptor and its HIV usage in heterozygotes (J Biol Chem. 277,", "synonym_substitution": "a) we identified the structural requirements of chemokine receptors for the biological affair and HIV use (J Biol Chem. 276, 40133, 2001);b) investigated how naturally occurring CCR5 mutants mar for surface expression affect the physiological function of the wt receptor and its HIV use in heterozygotes (J Biol Chem. 277,", "butter_fingers": " a) ae identified the structmral requirements of chxmokine receptofs for the biological functiln and YIV usage (J Biol Chem. 276, 40133, 2001);b) invesnigated hiw neturally occurriif CCR5 mmcants lmpaixev for surface ewpression ikpact the physhouoyical function of the wt receptor anq its HOV usage in hetetozygpees (N Biol Chem. 277,", "random_deletion": "a) we identified the structural requirements of for biological function HIV usage (J investigated naturally occurring CCR5 impaired for surface impact the physiological function of the receptor and its HIV usage in heterozygotes (J Biol Chem. 277,", "change_char_case": " a) we identified the structuraL requiremeNts of CheMokInE recEptoRs for the biologICal fUnction and HIV usage (J BioL Chem. 276, 40133, 2001);B) iNVestIGaTed hoW naturaLLy OCCurRiNg cCR5 MuTAnTs impAirEd for suRface expreSsiOn Impact the phySIoLogical funCtiOn of the wt recEptOr and iTs hIV USage iN heTerozYgotes (j biol ChEm. 277,", "whitespace_perturbation": " a) we identified the stru ctural req uirem ent s o fchem okin e receptors fo r  the  biological function a nd HI Vu sage (J  Biol  Chem.2 76 , 401 33 ,200 1) ; b)  inve sti gated h ow natural lyoc curring CCR5 mu tants impa ire d for surfac e e xpress io n i m pactthe  phys iologi c al fun ction ofth e  wt re c eptor a n d  i ts H IV usage in heter o zy g otes (J Biol C hem. 2 77 , ", "underscore_trick": " a)_we identified_the structural requirements of_chemokine receptors_for_the biological_function_and HIV usage_(J Biol Chem._276, 40133, 2001);b) investigated_how naturally occurring_CCR5_mutants impaired for surface expression impact the physiological function of the wt receptor and_its_HIV usage_in_heterozygotes_(J Biol Chem. 277,"}
{"text": " miniature excitatory currents;b) mutations that cause synaptic overgrowth are associated with a dramatic reduction of NLG protein. 2) BAG3 proteins are co-chaperones implicated in cell survival, proliferation and migration. In collaboration with Dr. Victoria Virador of NCI, David Sandstrom is studying the Drosophila", "synonym_substitution": "miniature excitatory currents;b) mutations that cause synaptic overgrowth are associated with a dramatic decrease of NLG protein. 2) BAG3 protein are colorado - chaperones implicate in cellular telephone survival, proliferation and migration. In collaboration with Dr. Victoria Virador of NCI, David Sandstrom is studying the Drosophila", "butter_fingers": " mijiature excitatory currekts;b) mutations tkqt cauve synzptic ovdrgrowth are associated with a dramqtic reduction of NLG orotein. 2) HAG3 protwins qre co-chapxdones implicafcd in rell survival, ptoliferation and migration. Iv eollaboration with Dr. Victoria Viradjr of NVI, David Sandstrjm ix stusjikg the Drosophila", "random_deletion": "miniature excitatory currents;b) mutations that cause synaptic associated a dramatic of NLG protein. implicated cell survival, proliferation migration. In collaboration Dr. Victoria Virador of NCI, David is studying the Drosophila", "change_char_case": " miniature excitatory currenTs;b) mutatioNs thaT caUse SyNaptIc ovErgrowth are assOCiatEd with a dramatic reductiOn of NlG PRoteIN. 2) BaG3 proTeins arE Co-CHApeRoNeS imPlICaTed in CelL survivAl, proliferAtiOn And migration. iN cOllaboratiOn wIth Dr. VictoriA ViRador oF NcI, DAVid SaNdsTrom iS studyINg the DRosophila", "whitespace_perturbation": " miniature excitatory curr ents;b) mu tatio nstha tcaus e sy naptic overgro w th a re associated with a d ramat ic redu c ti on of  NLG pr o te i n . 2 )BA G3pr o te ins a reco-chap erones imp lic at ed in cell s u rv ival, prol ife ration and m igr ation.  I n c o llabo rat ion w ith Dr .  Victo ria Virad or of NCI ,  DavidS a nd stro m is studying the Dr o sophila", "underscore_trick": " miniature_excitatory currents;b)_mutations that cause synaptic_overgrowth are_associated_with a_dramatic_reduction of NLG_protein. 2) BAG3_proteins are co-chaperones implicated_in cell survival,_proliferation_and migration. In collaboration with Dr. Victoria Virador of NCI, David Sandstrom is studying_the_Drosophila"}
{"text": " have a functional XPR1 receptor and can be infected by X-MLVs. In our most recent study on X/P-MLV entry, we shifted our attention from restrictive receptors to the permissive XPR1 receptors that mediate entry of all X/P-MLVs. Most Mus species and some laboratory", "synonym_substitution": "have a functional XPR1 receptor and can be infected by ten - MLVs. In our about recent study on X / P - MLV entrance, we shift our attention from restrictive receptors to the permissive XPR1 sense organ that intercede entry of all X / P - MLVs. Most Mus species and some laboratory", "butter_fingers": " hage a functional XPR1 recektor and can be iudected by X-MMVs. In ojr most recent study on X/P-MLT enrry, wt shifted our attengion from restricrive eeceptors vk the pcxmissjye XPX1 ceceptors that kediate endry of all X/P-MNVr. Lost Mus species and some laboratorr", "random_deletion": "have a functional XPR1 receptor and can by In our recent study on attention restrictive receptors to permissive XPR1 receptors mediate entry of all X/P-MLVs. Most species and some laboratory", "change_char_case": " have a functional XPR1 receptoR and can be iNfectEd bY X-MlVS. In oUr moSt recent study oN x/P-MLv entry, we shifted our atteNtion FrOM resTRiCtive ReceptoRS tO THe pErMiSsiVe xpR1 RecepTorS that meDiate entry Of aLl x/P-MLVs. Most MuS SpEcies and soMe lAboratory", "whitespace_perturbation": " have a functional XPR1 re ceptor and  canbeinf ec tedby X -MLVs. In ourm ostrecent study on X/P-ML V ent ry ,  wes hi ftedour att e nt i o n f ro mres tr i ct ive r ece ptors t o the perm iss iv e XPR1 recep t or s that med iat e entry of a llX/P-ML Vs . M o st Mu s s pecie s ands ome la boratory", "underscore_trick": " have_a functional_XPR1 receptor and can_be infected_by_X-MLVs. In_our_most recent study_on X/P-MLV entry,_we shifted our attention_from restrictive receptors_to_the permissive XPR1 receptors that mediate entry of all X/P-MLVs. Most Mus species and_some_laboratory"}
{"text": " tissues, demonstrating DLC1s essential role for normal development. To address the role of DLC1 in adult tissues, we set out to generate a conditional Dlc1 knockout mouse. In collaboration with the Gene Targeting Facility at NCI-Frederick, mice with germline transmission of the conditional knockout allele", "synonym_substitution": "tissues, demonstrating DLC1s essential role for normal growth. To cover the role of DLC1 in adult tissues, we specify out to beget a conditional Dlc1 knockout mouse. In collaboration with the Gene Targeting Facility at NCI - Frederick, mice with germline infection of the conditional smasher allele", "butter_fingers": " tidsues, demonstrating DLC1s essential role for nocmal debelopmeng. To address the role of DLC1 ib aduot tissues, we set out go generane a condutioial Dlc1 knockout mouse. Ik colmwborctmon with the Geke Targetinc Facility at TCK-Fxederick, mice with germline transmisfion of tje conditional knobkjut zllele", "random_deletion": "tissues, demonstrating DLC1s essential role for normal address role of in adult tissues, a Dlc1 knockout mouse. collaboration with the Targeting Facility at NCI-Frederick, mice with transmission of the conditional knockout allele", "change_char_case": " tissues, demonstrating DLC1s eSsential roLe for NorMal DeVeloPmenT. To address the rOLe of dLC1 in adult tissues, we set Out to GeNEratE A cOnditIonal DlC1 KnOCKouT mOuSe. IN cOLlAboraTioN with thE Gene TargeTinG FAcility at NCI-fReDerick, mice WitH germline traNsmIssion Of The COnditIonAl knoCkout aLLele", "whitespace_perturbation": " tissues, demonstrating DL C1s essent ial r ole  fo rnorm al d evelopment. To addr ess the role of DLC1 i n adu lt tiss u es , weset out to g ene ra te  aco n di tiona l D lc1 kno ckout mous e.In  collaborati o nwith the G ene  Targeting F aci lity a tNCI - Frede ric k, mi ce wit h  germl ine trans mi s sion o f  the co n d it iona l knockout allele ", "underscore_trick": " tissues,_demonstrating DLC1s_essential role for normal_development. To_address_the role_of_DLC1 in adult_tissues, we set_out to generate a_conditional Dlc1 knockout_mouse._In collaboration with the Gene Targeting Facility at NCI-Frederick, mice with germline transmission of_the_conditional knockout_allele"}
{"text": " studies on the development of humoral and cellular responses to blood-stage antigens of malaria parasites. Analysis has shown that children with HbAS are significantly protected against malaria in this population; this was not true for children with the HbAC genotype. Increasing age, a surrogate of acquired immunity, was also protective. Because long-", "synonym_substitution": "studies on the development of humoral and cellular responses to blood - stagecoach antigen of malaria parasites. Analysis has testify that child with HbAS are significantly protected against malaria in this population; this was not on-key for child with the HbAC genotype. Increasing historic period, a surrogate of acquired exemption, was also protective. Because long-", "butter_fingers": " stkdies on the development of humoral and celluler respknses to blood-stage antigens of malacia parasutes. Analysis has showv that chpldren wirh HuAS are significehtly protectes agannwt malaria in jhis populathon; this was nmt txue for children with the HbAC genotrpe. Inctewsing age, a sutrogaue jf adquired immunity, was also protectibe. Becalse long-", "random_deletion": "studies on the development of humoral and to antigens of parasites. Analysis has are protected against malaria this population; this not true for children with the genotype. Increasing age, a surrogate of acquired immunity, was also protective. Because long-", "change_char_case": " studies on the development of Humoral and CelluLar ResPoNses To blOod-stage antigeNS of mAlaria parasites. AnalysiS has sHoWN thaT ChIldreN with Hbas aRE SigNiFiCanTlY PrOtectEd aGainst mAlaria in thIs pOpUlation; this wAS nOt true for cHilDren with the HBAC GenotyPe. incREasinG agE, a surRogate OF acquiRed immuniTy, WAs also PRotectiVE. beCausE long-", "whitespace_perturbation": " studies on the developmen t of humor al an d c ell ul ar r espo nses to blood- s tage  antigens of malaria p arasi te s . An a ly sis h as show n  t h a t c hi ld ren  w i th  HbAS  ar e signi ficantly p rot ec ted againstm al aria in th ispopulation;thi s wasno t t r ue fo r c hildr en wit h  the H bAC genot yp e . Incr e asing a g e ,a su rrogate of acquir e di mmunity, was a lso pr ot e ct i v e.Bec ause long- ", "underscore_trick": " studies_on the_development of humoral and_cellular responses_to_blood-stage antigens_of_malaria parasites. Analysis_has shown that_children with HbAS are_significantly protected against_malaria_in this population; this was not true for children with the HbAC genotype. Increasing_age,_a surrogate_of_acquired_immunity, was also protective. Because_long-"}
{"text": " prospective study of the cause of neurologic disorders and other conditions in U.S. children. Pregnant women were enrolled when they presented for prenatal care. The CPP mothers were urban dwellers, and had a median socioeconomic index 7% below the U.S. value. The mothers? nonfasting blood", "synonym_substitution": "prospective study of the cause of neurologic disorders and early condition in U.S. children. meaning woman were enrolled when they presented for prenatal concern. The CPP mother were urban dwellers, and have a median socioeconomic index 7% below the U.S. value. The mother? nonfasting blood", "butter_fingers": " prlspective study of the cxuse of neuroloyuc dismrders and othdr conditions in U.S. children. Peegnabt women were enrolled when thej presentwd fie prenatal care. Thc CPP lothzrw were urban deellers, ang had a median sucnoeconomic index 7% below the U.S. value. The moyhfrs? nonfasting blopq", "random_deletion": "prospective study of the cause of neurologic other in U.S. Pregnant women were prenatal The CPP mothers urban dwellers, and a median socioeconomic index 7% below U.S. value. The mothers? nonfasting blood", "change_char_case": " prospective study of the causE of neuroloGic diSorDerS aNd otHer cOnditions in U.S. cHIldrEn. Pregnant women were enrOlled WhEN theY PrEsentEd for prENaTAL caRe. thE CPp mOThErs weRe uRban dweLlers, and haD a mEdIan socioeconOMiC index 7% beloW thE U.S. value. The mOthErs? nonFaStiNG blooD", "whitespace_perturbation": " prospective study of thecause of n eurol ogi c d is orde rs a nd other condi t ions  in U.S. children. Pre gnant  w o menw er e enr olled w h en t hey  p re sen te d  f or pr ena tal car e. The CPP  mo th ers were urb a ndwellers,and  had a media n s ocioec on omi c  inde x 7 % bel ow the U.S. v alue. The  m o thers? nonfast i n gbloo d", "underscore_trick": " prospective_study of_the cause of neurologic_disorders and_other_conditions in_U.S._children. Pregnant women_were enrolled when_they presented for prenatal_care. The CPP_mothers_were urban dwellers, and had a median socioeconomic index 7% below the U.S. value._The_mothers? nonfasting_blood"}
{"text": " plasticity of the connections between neurons, or synapses, is critical for refining brain circuitry during postnatal development. Similar mechanisms for changing synapses are likely to serve the basis for learning in the adult. Our primary interest, therefore, has been to determine the molecular basis of long-lasting synaptic plasticity. Toward our goal of learning", "synonym_substitution": "plasticity of the connections between neurons, or synapses, is critical for refine mind circuitry during postnatal development. Similar mechanisms for change synapses are likely to suffice the footing for learning in the adult. Our primary interest, therefore, has been to determine the molecular footing of long - lasting synaptic plasticity. Toward our goal of learning", "butter_fingers": " plwsticity of the connectiuns between neutobs, or vynapsss, is crktical for refining brain ciccuirry dyring postnatal develooment. Simplar mechqnisnw for chanjjng synapses zve linxly to serve thg basis for nearning in tha xdblt. Our primary interest, therefore, hws been tl determine thg moltcujar gasis of long-lasting synaptic plasficity. Uoward our goal of learning", "random_deletion": "plasticity of the connections between neurons, or critical refining brain during postnatal development. are to serve the for learning in adult. Our primary interest, therefore, has to determine the molecular basis of long-lasting synaptic plasticity. Toward our goal of", "change_char_case": " plasticity of the connectionS between neUrons, Or sYnaPsEs, is CritIcal for refininG BraiN circuitry during postnaTal deVeLOpmeNT. SImilaR mechanISmS FOr cHaNgIng SyNApSes arE liKely to sErve the basIs fOr Learning in thE AdUlt. Our primAry Interest, therEfoRe, has bEeN to DEtermIne The moLeculaR Basis oF long-lastInG SynaptIC plastiCITy. towaRd our goal of learniNG", "whitespace_perturbation": " plasticity of the connect ions betwe en ne uro ns,  o r sy naps es, is critica l  for  refining brain circui try d ur i ng p o st natal  develo p me n t . S im il arme c ha nisms  fo r chang ing synaps esar e likely tos er ve the bas isfor learning  in  the a du lt. Our p rim ary i nteres t , ther efore, ha sb een to determi n e  t he m olecular basis of lo n g-lasting syna ptic p la s ti c i ty.  To ward our g oa l ofl earning ", "underscore_trick": " plasticity_of the_connections between neurons, or_synapses, is_critical_for refining_brain_circuitry during postnatal_development. Similar mechanisms_for changing synapses are_likely to serve_the_basis for learning in the adult. Our primary interest, therefore, has been to determine_the_molecular basis_of_long-lasting_synaptic plasticity. Toward our goal_of learning"}
{"text": " to overcome the mutant phenotype. Thus, although Ryr is most well known for its role in muscle physiology, its action in neurons and/or glia is vital for anesthetic responsiveness. In addition to focused studies of general anesthesia, we apply our expertise in Drosophila neurobiology to genes of general interest via collaborative studies.", "synonym_substitution": "to overcome the mutant phenotype. Thus, although Ryr is most well known for its function in muscleman physiology, its action in neurons and/or glia is vital for anaesthetic responsiveness. In addition to focused studies of cosmopolitan anesthesia, we give our expertise in Drosophila neurobiology to gene of cosmopolitan interest via collaborative studies.", "butter_fingers": " to overcome the mutant phekotype. Thus, although Ryc is moat well ynown for its role in muscle pyysiooogy, its action in neufons and/og glia is vitel for anesthetir responsivenead. In eddition to focosed studies of general anasghzsia, we apply our expertise in Droso[hila nrugobiology to ggnes ps gehvrcl interest via collaborative sfudies.", "random_deletion": "to overcome the mutant phenotype. Thus, although most known for role in muscle and/or is vital for responsiveness. In addition focused studies of general anesthesia, we our expertise in Drosophila neurobiology to genes of general interest via collaborative studies.", "change_char_case": " to overcome the mutant phenotYpe. Thus, altHough ryr Is mOsT welL knoWn for its role in MUsclE physiology, its action in NeuroNs ANd/or GLiA is viTal for aNEsTHEtiC rEsPonSiVEnEss. In AddItion to Focused stuDieS oF general anesTHeSia, we apply Our Expertise in DRosOphila NeUroBIologY to Genes Of geneRAl inteRest via coLlABoratiVE studieS.", "whitespace_perturbation": " to overcome the mutant ph enotype. T hus,alt hou gh  Ryr  ismost well know n  for  its role in muscle ph ysiol og y , it s  a ction  in neu r on s and /o rgli ai svital  fo r anest hetic resp ons iv eness. In ad d it ion to foc use d studies of  ge neralan est h esia,  we  appl y oure xperti se in Dro so p hila n e urobiol o g yto g enes of general i n te r est via collab orativ es tu d i es. ", "underscore_trick": " to_overcome the_mutant phenotype. Thus, although_Ryr is_most_well known_for_its role in_muscle physiology, its_action in neurons and/or_glia is vital_for_anesthetic responsiveness. In addition to focused studies of general anesthesia, we apply our expertise_in_Drosophila neurobiology_to_genes_of general interest via collaborative_studies."}
{"text": " of the enteroendocrine cells and their differentiation process. Previous reports on characterization of entroendocrine cell differentiation using BrdU incorporation, morphological and immunohistochemical methods demonstrated that the majority of enteroendocrine cells complete the differentiation process within the crypt and migrate upward along the villus as mature hormone-producing cells.", "synonym_substitution": "of the enteroendocrine cells and their differentiation process. Previous report on word picture of entroendocrine cell differentiation using BrdU internalization, morphological and immunohistochemical methods demonstrated that the majority of enteroendocrine cellular telephone complete the differentiation procedure within the crypt and migrate upward along the villus as mature hormone - produce cells.", "butter_fingers": " of the enteroendocrine celus and their diyderentmation lrocess. Orevious reports on charactecizarion if entroendocrine cell differenniation uwing VrdU incor'kration, morphkpogieao and immunohixtochemican methods demotsgrcted that the majority of enteroendosrine crlps complete thg difgqrenfpauion process within the crypt and migratt upward along the villus as mature hormone-pgodufing cells.", "random_deletion": "of the enteroendocrine cells and their differentiation reports characterization of cell differentiation using methods that the majority enteroendocrine cells complete differentiation process within the crypt and upward along the villus as mature hormone-producing cells.", "change_char_case": " of the enteroendocrine cells And their diFfereNtiAtiOn ProcEss. PRevious reports ON chaRacterization of entroenDocriNe CEll dIFfErentIation uSInG bRdU InCoRpoRaTIoN, morpHolOgical aNd immunohiStoChEmical methodS DeMonstrated ThaT the majority Of eNteroeNdOcrINe celLs cOmpleTe the dIFferenTiation prOcESs withIN the cryPT AnD migRate upward along thE ViLLus as mature horMone-prOdUCiNG CelLs.", "whitespace_perturbation": " of the enteroendocrine ce lls and th eir d iff ere nt iati on p rocess. Previo u s re ports on characterizat ion o fe ntro e nd ocrin e celld if f e ren ti at ion  u s in g Brd U i ncorpor ation, mor pho lo gical and im m un ohistochem ica l methods de mon strate dtha t  themaj ority  of en t eroend ocrine ce ll s  compl e te thed i ff eren tiation process w i th i n the crypt an d migr at e  u p w ard  al ong the vi ll us as matureh or m o n e-p r oducing cells .", "underscore_trick": " of_the enteroendocrine_cells and their differentiation_process. Previous_reports_on characterization_of_entroendocrine cell differentiation_using BrdU incorporation,_morphological and immunohistochemical methods_demonstrated that the_majority_of enteroendocrine cells complete the differentiation process within the crypt and migrate upward along_the_villus as_mature_hormone-producing_cells."}
{"text": " insertion sites. This suggested transcription factors played a role in directing Tf1 integration. Hoffman and colleagues showed previously that the transcription factor Atf1p binds to and activates the promoter of fbp1. We tested whether the promoter of fbp1 is a target of Tf1 integration using the target plasmid assay.", "synonym_substitution": "insertion sites. This suggested transcription divisor play a role in directing Tf1 integration. Hoffman and colleague showed previously that the transcription gene Atf1p constipate to and activates the promoter of fbp1. We tested whether the promoter of fbp1 is a aim of Tf1 integration using the aim plasmid assay.", "butter_fingers": " indertion sites. This suggerted transcriptnin facvors plzyed a rule in directing Tf1 integratmon. Yoffmqn and colleagues showdd previolsly that the rranscriptmkn factor Atf1l binbs to and activajes the prommter of fbp1. We tdsced whether the promoter of fbp1 is a target ov Tf1 integratijn uxyng fhe target plasmid assay.", "random_deletion": "insertion sites. This suggested transcription factors played in Tf1 integration. and colleagues showed Atf1p to and activates promoter of fbp1. tested whether the promoter of fbp1 a target of Tf1 integration using the target plasmid assay.", "change_char_case": " insertion sites. This suggestEd transcriPtion FacTorS pLayeD a roLe in directing TF1 InteGration. Hoffman and colleAgues ShOWed pREvIouslY that thE TrANScrIpTiOn fAcTOr atf1p bIndS to and aCtivates thE prOmOter of fbp1. We tEStEd whether tHe pRomoter of fbp1 Is a Target Of tf1 iNTegraTioN usinG the taRGet plaSmid assay.", "whitespace_perturbation": " insertion sites. This sug gested tra nscri pti onfa ctor s pl ayed a role in dire cting Tf1 integration.  Hoff ma n  and co lleag ues sho w ed p rev io us lyth a tthe t ran scripti on factorAtf 1p  binds to an d  a ctivates t hepromoter offbp 1. Wete ste d  whet her  thepromot e r of f bp1 is ata r get of Tf1 int e g ra tion  using the target pl a smid assay.", "underscore_trick": " insertion_sites. This_suggested transcription factors played_a role_in_directing Tf1_integration._Hoffman and colleagues_showed previously that_the transcription factor Atf1p_binds to and_activates_the promoter of fbp1. We tested whether the promoter of fbp1 is a target_of_Tf1 integration_using_the_target plasmid assay."}
{"text": " fraction of CD5hi T cell can be seen when comparing cord blood and adult samples from humans. These findings are surprising in light of several decades of work on the structural basis of T cell pMHC recognition and the role of peptides vs. MHC molecules in thymic selection and peripheral antigen recognition. Our observations indicate that", "synonym_substitution": "fraction of CD5hi T cell can be seen when comparing cord blood and adult sample from world. These findings are surprising in light of several ten of work on the structural footing of T cell pMHC recognition and the function of peptides vs. MHC molecules in thymic excerpt and peripheral antigen recognition. Our observations argue that", "butter_fingers": " frwction of CD5hi T cell cak be seen when comparinj cord glood ana adult samples from humans. Vhesw fineings are surprising iv light ov severao derades of work on the strmeturam basns of T cell pMHG recognitimn and the rola uf peptides vs. MHC molecules in thymis selecyiln and periphetal ameigeh recognition. Our observations indjcate tiat", "random_deletion": "fraction of CD5hi T cell can be comparing blood and samples from humans. light several decades of on the structural of T cell pMHC recognition and role of peptides vs. MHC molecules in thymic selection and peripheral antigen recognition. observations indicate that", "change_char_case": " fraction of CD5hi T cell can be sEen when comParinG coRd bLoOd anD aduLt samples from hUMans. these findings are surpriSing iN lIGht oF SeVeral Decades OF wORK on ThE sTruCtURaL basiS of t cell pMhC recognitIon AnD the role of pePTiDes vs. MHC moLecUles in thymic SelEction AnD peRIpherAl aNtigeN recogNItion. OUr observaTiONs indiCAte that", "whitespace_perturbation": " fraction of CD5hi T cellcan be see n whe n c omp ar ingcord  blood and adu l t sa mples from humans. The se fi nd i ngsa re  surp risingi nl i ght  o fsev er a ldecad esof work  on the st ruc tu ral basis of Tcell pMHCrec ognition and  th e role  o f p e ptide s v s. MH C mole c ules i n thymicse l ection and per i p he ralantigen recogniti o n. Our observatio ns ind ic a te t hat ", "underscore_trick": " fraction_of CD5hi_T cell can be_seen when_comparing_cord blood_and_adult samples from_humans. These findings_are surprising in light_of several decades_of_work on the structural basis of T cell pMHC recognition and the role of_peptides_vs. MHC_molecules_in_thymic selection and peripheral antigen_recognition. Our observations indicate that"}
{"text": " we found that synaptic responses in CA2 were very similar to those in the neighboring CA1 and CA3 areas. We later established that dendritic spines in CA2 have very different calcium dynamics from spines in CA1 and CA3 in that both calcium buffering capacity and rates of calcium extrusion were higher in CA2 spines when", "synonym_substitution": "we found that synaptic responses in CA2 were very similar to those in the neighboring CA1 and CA3 areas. We subsequently prove that dendritic spines in CA2 have very different calcium moral force from spines in CA1 and CA3 in that both calcium buffering capacity and rates of calcium bulge were high in CA2 spines when", "butter_fingers": " we found that synaptic reskonses in CA2 were very smmilar fo those in the neighboring CA1 and CE3 arwas. Wt later established that denfritic spinew in CA2 havx very dlyferehb caleinm dynamics frok spines it CA1 and CA3 in tfac both calcium buffering capacity anq rates ov calcium extrosion rere higher in CA2 spines when", "random_deletion": "we found that synaptic responses in CA2 similar those in neighboring CA1 and that spines in CA2 very different calcium from spines in CA1 and CA3 that both calcium buffering capacity and rates of calcium extrusion were higher in spines when", "change_char_case": " we found that synaptic responSes in CA2 werE very SimIlaR tO thoSe in The neighboring ca1 and cA3 areas. We later establisHed thAt DEndrITiC spinEs in CA2 hAVe VERy dIfFeRenT cALcIum dyNamIcs from Spines in CA1 And cA3 In that both caLCiUm bufferinG caPacity and ratEs oF calciUm ExtRUsion WerE highEr in CA2 SPines wHen", "whitespace_perturbation": " we found that synaptic re sponses in  CA2wer e v er y si mila r to those int he n eighboring CA1 and CA3  area s. We l a te r est ablishe d  t h a t d en dr iti cs pi nes i n C A2 have  very diff ere nt  calcium dyn a mi cs from sp ine s in CA1 and  CA 3 in t ha t b o th ca lci um bu fferin g  capac ity and r at e s of c a lcium e x t ru sion  were higher in C A 2s pines when", "underscore_trick": " we_found that_synaptic responses in CA2_were very_similar_to those_in_the neighboring CA1_and CA3 areas._We later established that_dendritic spines in_CA2_have very different calcium dynamics from spines in CA1 and CA3 in that both_calcium_buffering capacity_and_rates_of calcium extrusion were higher_in CA2 spines when"}
{"text": "domain salt bridges in the lymphomagenic virus HR1 that could affect structural stability, entry or sensitivity to host immune responses. The long terminal repeats of lymphomagenic P-MLVs are differentially altered by recombinations, duplications or mutations. This analysis of the naturally occurring, sometimes pathogenic P-ML", "synonym_substitution": "domain salt bridges in the lymphomagenic virus HR1 that could affect geomorphologic constancy, entry or sensitivity to host immune answer. The farseeing terminal repeats of lymphomagenic P - MLVs are differentially interpolate by recombination, duplications or mutant. This analysis of the naturally occurring, sometimes pathogenic P - ML", "butter_fingers": "domwin salt bridges in the uymphomagenic vneus HR1 that dould afwect structural stability, envry ir sebsitivity to host immuve respondes. The oong rerminal rxleats on lymlmomagznmc P-MLVs are dinferentiallf altered by racumyinations, duplications or mutations. Ehis ansljsis of the najuralkr ocdlrving, sometimes pathogenic P-ML", "random_deletion": "domain salt bridges in the lymphomagenic virus could structural stability, or sensitivity to terminal of lymphomagenic P-MLVs differentially altered by duplications or mutations. This analysis of naturally occurring, sometimes pathogenic P-ML", "change_char_case": "domain salt bridges in the lymPhomagenic Virus hR1 tHat CoUld aFfecT structural staBIlitY, entry or sensitivity to hOst imMuNE resPOnSes. ThE long teRMiNAL rePeAtS of LyMPhOmageNic p-MLVs arE differentIalLy Altered by recOMbInations, duPliCations or mutAtiOns. ThiS aNalYSis of The NaturAlly ocCUrring, Sometimes PaTHogeniC p-ML", "whitespace_perturbation": "domain salt bridges in the  lymphomag enicvir usHR 1 th at c ould affect st r uctu ral stability, entry o r sen si t ivit y  t o hos t immun e  r e s pon se s.  Th el on g ter min al repe ats of lym pho ma genic P-MLVs ar e differen tia lly alteredbyrecomb in ati o ns, d upl icati ons or mutati ons. This  a n alysis of then a tu rall y occurring, some t im e s pathogenic P -ML", "underscore_trick": "domain salt_bridges in_the lymphomagenic virus HR1_that could_affect_structural stability,_entry_or sensitivity to_host immune responses._The long terminal repeats_of lymphomagenic P-MLVs_are_differentially altered by recombinations, duplications or mutations. This analysis of the naturally occurring, sometimes_pathogenic_P-ML"}
{"text": ", with 60% being down-regulated. The up-regulated genes were strongly associated with apoptosis. This subset of genes was referred to as \"Jun signature in HCC\". Applying a comparative functional genomics approach, we found orthologous genes of the Jun signature in human, and then integrated the gene profiles from mouse tumor samples", "synonym_substitution": ", with 60% being down - regulated. The up - regulated genes were strongly consociate with apoptosis. This subset of gene was referred to as \" Jun signature in HCC \". apply a relative functional genomics approach, we found orthologous gene of the Jun key signature in human, and then integrate the gene profiles from mouse tumor samples", "butter_fingers": ", wihh 60% being down-regulated. Uhe up-regulated ggnws werx stronfly assoziated with apoptosis. This snbser of tenes was referred to xs \"Jun sihnature un HRC\". Applying a comparativc fundbionan genomics apprpach, we fognd orthologouv eeues of the Jun signature in human, anq then onhegrated the ggne pgosilea from mouse tumor samples", "random_deletion": ", with 60% being down-regulated. The up-regulated strongly with apoptosis. subset of genes signature HCC\". Applying a functional genomics approach, found orthologous genes of the Jun in human, and then integrated the gene profiles from mouse tumor samples", "change_char_case": ", with 60% being down-regulated. The Up-regulateD geneS weRe sTrOnglY assOciated with apoPTosiS. This subset of genes was rEferrEd TO as \"JUN sIgnatUre in HCc\". apPLYinG a CoMpaRaTIvE funcTioNal genoMics approaCh, wE fOund orthologOUs Genes of the jun Signature in hUmaN, and thEn IntEGrateD thE gene ProfilES from mOuse tumor SaMPles", "whitespace_perturbation": ", with 60% being down-regu lated. The  up-r egu lat ed  gen es w ere strongly a s soci ated with apoptosis. T his s ub s et o f  g eneswas ref e rr e d  to  a s\"Ju ns ig natur e i n HCC\".  Applyinga c om parative fun c ti onal genom ics  approach, w e f ound o rt hol o gousgen es of  the J u n sign ature inhu m an, an d  then i n t eg rate d the gene profil e sf rom mouse tumo r samp le s ", "underscore_trick": ", with_60% being_down-regulated. The up-regulated genes_were strongly_associated_with apoptosis._This_subset of genes_was referred to_as \"Jun signature in_HCC\". Applying a_comparative_functional genomics approach, we found orthologous genes of the Jun signature in human, and_then_integrated the_gene_profiles_from mouse tumor samples"}
{"text": " several chemokine receptors. We show that Nef downmodulates some chemokine receptors to a variable extent based on the cell type, receptor, and primary cell donors. Of all the chemokine receptors examined, CXCR4 in different primary cells and tumor cell lines and CXCR1 and CXCR2 in certain cell lines were downregulated by different HIV", "synonym_substitution": "several chemokine receptors. We show that Nef downmodulates some chemokine receptors to a varying extent free-base on the cell type, sense organ, and primary cellular telephone donors. Of all the chemokine receptors examine, CXCR4 in unlike primary cells and tumor cell lines and CXCR1 and CXCR2 in certain cellular telephone lines were downregulated by different HIV", "butter_fingers": " segeral chemokine receptorr. We show that Uwf dowimodulafes some chemokine receptors to a vaciaboe exuvnt based on the cell type, recvptor, and prinqry cell donors. Of all tgc chekikine receptorx examined, CXCR4 in diffesevt primary cells and tumor cell lines and CXVR1 and CXCR2 in cgrtaim celm lines were downregulated by diffsrent HPV", "random_deletion": "several chemokine receptors. We show that Nef chemokine to a extent based on primary donors. Of all chemokine receptors examined, in different primary cells and tumor lines and CXCR1 and CXCR2 in certain cell lines were downregulated by different", "change_char_case": " several chemokine receptors. we show that nef doWnmOduLaTes sOme cHemokine receptORs to A variable extent based on The ceLl TYpe, rECePtor, aNd primaRY cELL doNoRs. of aLl THe ChemoKinE receptOrs examineD, CXcR4 In different pRImAry cells anD tuMor cell lines And cXCR1 anD CxCR2 IN certAin Cell lInes weRE downrEgulated bY dIFferenT hIV", "whitespace_perturbation": " several chemokine recepto rs. We sho w tha t N efdo wnmo dula tes some chemo k inereceptors to a variabl e ext en t  bas e don th e cellt yp e ,  re ce pt or,  a n dprima rycell do nors. Of a llth e chemokiner ec eptors exa min ed, CXCR4 in  di fferen tpri m ary c ell s and  tumor cell l ines andCX C R1 and CXCR2 i n ce rtai n cell lines were do w nregulated bydiffer en t  H I V ", "underscore_trick": " several_chemokine receptors._We show that Nef_downmodulates some_chemokine_receptors to_a_variable extent based_on the cell_type, receptor, and primary_cell donors. Of_all_the chemokine receptors examined, CXCR4 in different primary cells and tumor cell lines and_CXCR1_and CXCR2_in_certain_cell lines were downregulated by_different HIV"}
{"text": "11-13). IPT was not superior to health education (HE) to prevent excess weight gain at 1- or 3-year follow-up the entire cohort (11,12). However, among girls with high self-reported baseline social-adjustment problems or anxiety, IPT, compared to HE, was", "synonym_substitution": "11 - 13). IPT was not superior to health education (HE) to prevent excess weight gain at 1- or 3 - class follow - up the integral age group (11,12). However, among girls with high self - reported baseline social - adaptation problems or anxiety, IPT, compared to HE, was", "butter_fingers": "11-13). IPH was not superior to hexlth education (KW) to pcevent sxcess wdight gain at 1- or 3-year follox-up rhe ebtire cohort (11,12). However, xmong girps with yigh welf-reportxs basellue sodlal-adluwtment problemx or anxiedy, IPT, compareg go HE, was", "random_deletion": "11-13). IPT was not superior to health to excess weight at 1- or (11,12). among girls with self-reported baseline social-adjustment or anxiety, IPT, compared to HE,", "change_char_case": "11-13). IPT was not superior to health Education (He) to prEveNt eXcEss wEighT gain at 1- or 3-year fOLlow-Up the entire cohort (11,12). HowevEr, amoNg GIrls WItH high Self-repORtED BasElInE soCiAL-aDjustMenT probleMs or anxietY, IPt, cOmpared to HE, wAS", "whitespace_perturbation": "11-13). IPT was not superi or to heal th ed uca tio n(HE)  toprevent excess weig ht gain at 1- or 3-yea r fol lo w -upt he  enti re coho r t( 1 1,1 2) .How ev e r,  amon g g irls wi th high se lf- re ported basel i ne  social-ad jus tment proble msor anx ie ty, IPT,com pared  to HE ,  was", "underscore_trick": "11-13). IPT_was not_superior to health education_(HE) to_prevent_excess weight_gain_at 1- or_3-year follow-up the_entire cohort (11,12). However,_among girls with_high_self-reported baseline social-adjustment problems or anxiety, IPT, compared to HE, was"}
{"text": " cortical GABA levels. To our knowledge, this is the first study to measure GABA in living human brain. It is unclear whether this association reflects functional differences in enzyme activity or is a neuroanatomical decrease in the total number or distribution of interneurons or synapses. Another study examined a method to reproduce quantification of brain", "synonym_substitution": "cortical GABA levels. To our knowledge, this is the first study to quantify GABA in survive human brain. It is unclear whether this affiliation reflects running differences in enzyme activity or is a neuroanatomic decrease in the total number or distribution of interneurons or synapses. Another survey examined a method to regurgitate quantification of brain", "butter_fingers": " cogtical GABA levels. To ouv knowledge, this is the first study tu measure GABA in living humen beain. Ut is unclear whether ghis assobiation rwflerts functional dmrferenccf in cnzymz ectivity or is s neuroanadomical decreave iu the total number or distribution os intermekrons or synapfes. Sgothsg wtudy examined a method to relroduce quantificatipn of brain", "random_deletion": "cortical GABA levels. To our knowledge, this first to measure in living human this reflects functional differences enzyme activity or a neuroanatomical decrease in the total or distribution of interneurons or synapses. Another study examined a method to reproduce of brain", "change_char_case": " cortical GABA levels. To our knOwledge, thiS is thE fiRst StUdy tO meaSure GABA in liviNG humAn brain. It is unclear whetHer thIs ASsocIAtIon reFlects fUNcTIOnaL dIfFerEnCEs In enzYme ActivitY or is a neurOanAtOmical decreaSE iN the total nUmbEr or distribuTioN of intErNeuROns or SynApses. anotheR Study eXamined a mEtHOd to rePRoduce qUANtIficAtion of brain", "whitespace_perturbation": " cortical GABA levels. Toour knowle dge,thi s i sthefirs t study to mea s ureGABA in living human b rain.  I t  isu nc learwhether th i s  as so ci ati on re flect s f unction al differe nce sin enzyme ac t iv ity or isa n euroanatomic aldecrea se  in the t ota l num ber or distri bution of  i n terneu r ons ors y na pses . Another study e x am i ned a method t o repr od u ce q uan tif ication of  b rain", "underscore_trick": " cortical_GABA levels._To our knowledge, this_is the_first_study to_measure_GABA in living_human brain. It_is unclear whether this_association reflects functional_differences_in enzyme activity or is a neuroanatomical decrease in the total number or distribution_of_interneurons or_synapses._Another_study examined a method to_reproduce quantification of brain"}
{"text": "innings of LOC-eating in preadolescents with overweight/obesity show preliminary promise, particularly for reducing internalizing symptoms. Whether observed psychological benefits translate into sustained prevention of disordered-eating or excess weight gain requires further study. A new study is underway to examine if retraining attentional biases away from pal", "synonym_substitution": "innings of LOC - eating in preadolescents with overweight / obesity show preliminary promise, particularly for dilute internalize symptoms. Whether observed psychological benefit understand into sustained prevention of disordered - eating or excess weight addition requires further study. A fresh study is underway to test if retraining attentional biases aside from pal", "butter_fingers": "innlngs of LOC-eating in prexdolescents witk overwxight/obssity shuw preliminary promise, partirulaely fir reducing internalizkng symptlms. Whetyer ivserved psbdhologigcl behcfits vranslate into xustained [revention of giroxdered-eating or excess weight gain rqquires fkrther study. A new ftudg is underway to examine if retraihing atuentional biases aeay from pal", "random_deletion": "innings of LOC-eating in preadolescents with overweight/obesity promise, for reducing symptoms. Whether observed prevention disordered-eating or excess gain requires further A new study is underway to if retraining attentional biases away from pal", "change_char_case": "innings of LOC-eating in preadOlescents wIth ovErwEigHt/ObesIty sHow preliminary PRomiSe, particularly for reducIng inTeRNaliZInG sympToms. WheTHeR OBseRvEd PsyChOLoGical BenEfits trAnslate intO suStAined preventIOn Of disorderEd-eAting or excesS weIght gaIn ReqUIres fUrtHer stUdy. A neW Study iS underway To EXamine IF retraiNINg AtteNtional biases away FRoM Pal", "whitespace_perturbation": "innings of LOC-eating in p readolesce nts w ith  ov er weig ht/o besity show pr e limi nary promise, particul arlyfo r  red u ci ng in ternali z in g sym pt om s.Wh e th er ob ser ved psy chological  be ne fits transla t einto susta ine d prevention  of  disor de red - eatin g o r exc ess we i ght ga in requir es furthe r  study. A  n ew s tudy is underwayt oe xamine if retr aining  a t te n t ion albiases awa yfromp al", "underscore_trick": "innings of_LOC-eating in_preadolescents with overweight/obesity show_preliminary promise,_particularly_for reducing_internalizing_symptoms. Whether observed_psychological benefits translate_into sustained prevention of_disordered-eating or excess_weight_gain requires further study. A new study is underway to examine if retraining attentional_biases_away from_pal"}
{"text": " address this problem, we have pursued a new strategy using DNA aptamers. We had previously prepared several DNA aptamer libraries and performed repetitive selections on various targets, and we analyzed the selected aptamer populations using next-generation sequencing technology. We have focused on a small subset which binds to infected but not uninfected red cells", "synonym_substitution": "address this problem, we have pursued a new scheme use DNA aptamers. We had previously prepared respective DNA aptamer library and performed insistent selections on various targets, and we analyze the selected aptamer populations use next - generation sequence engineering. We have focused on a small subset which bind to infected but not uninfected red cell", "butter_fingers": " adfress this problem, we haye pursued a new stratejy usinf DNA apgamers. We had previously pre'aree sevtgal DNA aptamer librafies and ierformed repttitive selections on varljus fwrgecs, and we analyzgd the selecded aptamer po[uuacions using next-generation sequencind technpllgy. We have fosusec on z small subset which binds to infedted buu not uninfected rrd cells", "random_deletion": "address this problem, we have pursued a using aptamers. We previously prepared several repetitive on various targets, we analyzed the aptamer populations using next-generation sequencing technology. have focused on a small subset which binds to infected but not uninfected cells", "change_char_case": " address this problem, we have pUrsued a new StratEgy UsiNg dNA aPtamErs. We had previoUSly pRepared several DNA aptamEr libRaRIes aND pErforMed repeTItIVE seLeCtIonS oN VaRious TarGets, and We analyzed The SeLected aptameR PoPulations uSinG next-generatIon SequenCiNg tEChnolOgy. we havE focusED on a smAll subset WhICh bindS To infecTED bUt noT uninfected red celLS", "whitespace_perturbation": " address this problem, wehave pursu ed anew  st ra tegy  usi ng DNA aptamer s . We  had previously prepar ed se ve r al D N Aaptam er libr a ri e s  an dpe rfo rm e drepet iti ve sele ctions onvar io us targets,a nd  we analyz edthe selected  ap tamerpo pul a tions  us ing n ext-ge n eratio n sequenc in g  techn o logy. W e ha ve f ocused on a small su b set which bind s to i nf e ct e d  bu t n ot uninfec te d red cells", "underscore_trick": " address_this problem,_we have pursued a_new strategy_using_DNA aptamers._We_had previously prepared_several DNA aptamer_libraries and performed repetitive_selections on various_targets,_and we analyzed the selected aptamer populations using next-generation sequencing technology. We have focused_on_a small_subset_which_binds to infected but not_uninfected red cells"}
{"text": " those with the sickle cell trait (HbAS) and pairing them with age-matched HbAA controls. These children have been followed from 2009 to the present, with blood samples being obtained before and after the transmission season as well as during bouts of clinical malaria infection; these samples provide a unique and valuable resource for", "synonym_substitution": "those with the sickle cell trait (HbAS) and pairing them with age - matched HbAA control. These child have been followed from 2009 to the present, with blood samples being receive before and after the transmission season equally well as during bouts of clinical malaria infection; these samples supply a unique and valuable resource for", "butter_fingers": " thlse with the sickle cell trait (HbAS) and pairinj them sith age-oatched HbAA controls. These rhileren yave been followed froo 2009 to the present, witi blood samples using obbcined neforz end after the ttansmission veason as well ar buring bouts of clinical malaria infqction; yhfse samples prjvidt a unisle and valuable resource for", "random_deletion": "those with the sickle cell trait (HbAS) them age-matched HbAA These children have the with blood samples obtained before and the transmission season as well as bouts of clinical malaria infection; these samples provide a unique and valuable resource", "change_char_case": " those with the sickle cell traIt (HbAS) and pAirinG thEm wItH age-MatcHed HbAA controlS. thesE children have been folloWed frOm 2009 TO the PReSent, wIth blooD SaMPLes BeInG obTaINeD befoRe aNd after The transmiSsiOn Season as well AS dUring bouts Of cLinical malarIa iNfectiOn; TheSE sampLes ProviDe a uniQUe and vAluable reSoURce for", "whitespace_perturbation": " those with the sickle cel l trait (H bAS)and  pa ir ingthem  with age-matc h ed H bAA controls. These ch ildre nh aveb ee n fol lowed f r om 2 009  t othe  p r es ent,wit h blood  samples b ein gobtained bef o re  and after  th e transmissi onseason  a s w e ll as  du ringboutso f clin ical mala ri a  infec t ion; th e s esamp les provide a uni q ue and valuable r esourc ef or ", "underscore_trick": " those_with the_sickle cell trait (HbAS)_and pairing_them_with age-matched_HbAA_controls. These children_have been followed_from 2009 to the_present, with blood_samples_being obtained before and after the transmission season as well as during bouts of_clinical_malaria infection;_these_samples_provide a unique and valuable_resource for"}