Add example code for obtaining non-zero median digests

examples/pretraining_new_model/obtain_nonzero_median_digests.ipynb

@@ -0,0 +1,365 @@
+{
+ "cells": [
+  {
+   "cell_type": "markdown",
+   "id": "charged-worcester",
+   "metadata": {},
+   "source": [
+    "# Obtain non-zero median expression value of each gene across Genecorpus-30M"
+   ]
+  },
+  {
+   "cell_type": "markdown",
+   "id": "28e87f2a-a33e-4fe3-81af-ad4cd62fcc1b",
+   "metadata": {},
+   "source": [
+    "#### Upon request, we are providing the code that we used for obtaining the non-zero median expression value of each gene across the broad range of cell types represented in Genecorpus-30M that we use as a normalization factor to prioritize genes that uniquely distinguish cell state.\n",
+    "\n",
+    "#### Please read the important information below before using this code.\n",
+    "\n",
+    "#### If using Geneformer, to ensure consistency of the normalization factor used for each gene for all future datasets,  <ins>**users should use the Geneformer transcriptome tokenizer to tokenize their datasets and should not re-calculate this normalization factor for their individual dataset** </ins>. This code for re-calculating the normalization factor should only be used by users who are pretraining a new model from scratch with a new pretraining corpus other than Genecorpus-30M.\n",
+    "\n",
+    "#### It is critical that this calculation is performed on a large-scale pretraining corpus that has tens of millions of cells from a broad range of human tissues.  <ins>**The richness of variable cell states in the pretraining corpus is what allows this normalization factor to accomplish the goal of prioritizing genes that uniquely distinguish cell states.** </ins> This normalization factor for each gene is calculated once from the large-scale pretraining corpus and is used for all future datasets presented to the model. \n",
+    "\n",
+    "#### Of note, as discussed in the Methods, we only included droplet-based sequencing platforms in the pretraining corpus to assure expression value unit comparability for the calculation of this normalization factor. Users wishing to pretrain a new model from scratch with a new pretraining corpus should choose either droplet-based or plate-based platforms for calculating this normalization factor, or they should exercise caution that including both platforms may cause unintended effects on the results. Once the normalization factor is calculated however, data from any platform can be used with the model because the expression value units will be consistent within each individual cell.\n",
+    "\n",
+    "#### Please see the Methods in the manuscript for a description of the procedure enacted by this code, an excerpt of which is below for convenience:\n",
+    "\n",
+    "#### \"To accomplish this, we first calculated the non-zero median value of expression of each detected gene across all cells passing quality filtering from the entire Genecorpus-30M. We aggregated the transcript count distribution for each gene in a memory-efficient manner by scanning through chunks of .loom data using loompy, normalizing the gene transcript counts in each cell by the total transcript count of that cell to account for varying sequencing depth and updating the normalized count distribution of the gene within the t-digest data structure developed for accurate online accumulation of rank-based statistics. We then normalized the genes in each single-cell transcriptome by the non-zero median value of expression of that gene across Genecorpus-30M and ordered the genes by the rank of their normalized expression in that specific cell. Of note, we opted to use the non-zero median value of expression rather than include zeros in the distribution so as not to weight the value by tissue representation within Genecorpus-30M, assuming that a representative range of transcript values would be observed within the cells in which each gene was detected. This normalization factor for each gene is calculated once from the pretraining corpus and is used for all future datasets presented to the model. The provided tokenizer code includes this normalization procedure and should be used for tokenizing new datasets presented to Geneformer to ensure consistency of the normalization factor used for each gene.\""
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 1,
+   "id": "textile-destruction",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "import os\n",
+    "import numpy as np\n",
+    "import loompy as lp\n",
+    "import pandas as pd\n",
+    "import crick\n",
+    "import pickle\n",
+    "import math\n",
+    "from tqdm.notebook import tqdm"
+   ]
+  },
+  {
+   "cell_type": "markdown",
+   "id": "4af8cfef-05f2-47e0-b8d2-71ca025059c7",
+   "metadata": {
+    "tags": []
+   },
+   "source": [
+    "### The following code is an example of how the nonzero median expression values are obtained for a single input file. This calculation should be run as a script to be parallelized for all dataset files."
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 30,
+   "id": "physical-intro",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "input_file = \"study1.loom\"\n",
+    "current_database = \"database1\"\n",
+    "\n",
+    "rootdir = f\"/path/to/{current_database}/data/\"\n",
+    "output_file = input_file.replace(\".loom\", \".gene_median_digest_dict.pickle\")\n",
+    "outdir = rootdir.replace(\"/data/\", \"/tdigest/\")\n",
+    "\n",
+    "with lp.connect(f\"{rootdir}{input_file}\") as data:\n",
+    "    # define coordinates of protein-coding or miRNA genes\n",
+    "    coding_miRNA_loc = np.where((data.ra.gene_type == \"protein_coding\") | (data.ra.gene_type == \"miRNA\"))[0]\n",
+    "    coding_miRNA_genes = data.ra[\"ensembl_id\"][coding_miRNA_loc]\n",
+    "    \n",
+    "    # initiate tdigests\n",
+    "    median_digests = [crick.tdigest.TDigest() for _ in range(len(coding_miRNA_loc))]\n",
+    "    \n",
+    "    # initiate progress meters\n",
+    "    progress = tqdm(total=len(coding_miRNA_loc))\n",
+    "    last_view_row = 0\n",
+    "    progress.update(0)\n",
+    "    \n",
+    "    for (ix, selection, view) in data.scan(items=coding_miRNA_loc, axis=0):\n",
+    "        # define coordinates of cells passing filter\n",
+    "        filter_passed_loc = np.where(view.ca.filter_pass == 1)[0]\n",
+    "        subview = view.view[:, filter_passed_loc]\n",
+    "        # normalize by total counts per cell and multiply by 10,000 to allocate bits to precision\n",
+    "        subview_norm_array = subview[:,:]/subview.ca.n_counts*10_000\n",
+    "         # if integer, convert to float to prevent error with filling with nan\n",
+    "        if np.issubdtype(subview_norm_array.dtype, np.integer):\n",
+    "            subview_norm_array = subview_norm_array.astype(np.float32)\n",
+    "        # mask zeroes from distribution tdigest by filling with nan\n",
+    "        nonzero_data = np.ma.masked_equal(subview_norm_array, 0.0).filled(np.nan)\n",
+    "        # update tdigests\n",
+    "        [median_digests[i+last_view_row].update(nonzero_data[i,:]) for i in range(nonzero_data.shape[0])]\n",
+    "        # update progress meters\n",
+    "        progress.update(view.shape[0])\n",
+    "        last_view_row = last_view_row + view.shape[0]\n",
+    "        \n",
+    "median_digest_dict = dict(zip(coding_miRNA_genes, median_digests))\n",
+    "with open(f\"{outdir}{output_file}\", \"wb\") as fp:\n",
+    "    pickle.dump(median_digest_dict, fp)"
+   ]
+  },
+  {
+   "cell_type": "markdown",
+   "id": "190a3754-aafa-4ccf-ba97-951c94ea3030",
+   "metadata": {
+    "tags": []
+   },
+   "source": [
+    "### After the above code is run as a script in parallel for all datasets to obtain the nonzero median tdigests for their contained genes, the following code can be run to merge the tdigests across all datasets."
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 2,
+   "id": "distributed-riding",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "# merge new tdigests into total tdigest dict\n",
+    "def merge_digest(dict_key_ensembl_id, dict_value_tdigest, new_tdigest_dict):\n",
+    "    new_gene_tdigest = new_tdigest_dict.get(dict_key_ensembl_id)\n",
+    "    if new_gene_tdigest is not None:\n",
+    "        dict_value_tdigest.merge(new_gene_tdigest)\n",
+    "        return dict_value_tdigest\n",
+    "    elif new_gene_tdigest is None:\n",
+    "        return dict_value_tdigest"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": null,
+   "id": "distinct-library",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "# use tdigest1.merge(tdigest2) to merge tdigest1, tdigest2, ...tdigestn\n",
+    "# then, extract median by tdigest1.quantile(0.5)\n",
+    "\n",
+    "databases = [\"database1\", \"database2\", \"...databaseN\"]\n",
+    "\n",
+    "# obtain gene list\n",
+    "gene_info = pd.read_csv(\"/path/to/gene_info_table.csv\", index_col=0)\n",
+    "func_gene_list = [i for i in gene_info[(gene_info[\"gene_type\"] == \"protein_coding\") | (gene_info[\"gene_type\"] == \"miRNA\")][\"ensembl_id\"]]\n",
+    "\n",
+    "# initiate tdigests\n",
+    "median_digests = [crick.tdigest.TDigest() for _ in range(len(func_gene_list))]\n",
+    "total_tdigest_dict = dict(zip(func_gene_list, median_digests))\n",
+    "\n",
+    "# merge tdigests\n",
+    "for current_database in databases:\n",
+    "    rootdir = f\"/path/to/{current_database}/tdigest/\"\n",
+    "    \n",
+    "    for subdir, dirs, files in os.walk(rootdir):\t\n",
+    "        for file in files:\n",
+    "            if file.endswith(\".gene_median_digest_dict.pickle\"):\n",
+    "                with open(f\"{rootdir}{file}\", \"rb\") as fp:\n",
+    "                    tdigest_dict = pickle.load(fp)\n",
+    "                total_tdigest_dict = {k: merge_digest(k,v,tdigest_dict) for k, v in total_tdigest_dict.items()}\n",
+    "\n",
+    "# save dict of merged tdigests\n",
+    "with open(f\"/path/to/total_gene_tdigest_dict.pickle\", \"wb\") as fp:\n",
+    "    pickle.dump(total_tdigest_dict, fp)\n",
+    "\n",
+    "# extract medians and save dict\n",
+    "total_median_dict = {k: v.quantile(0.5) for k, v in total_tdigest_dict.items()}\n",
+    "with open(f\"/path/to/total_gene_median_dict.pickle\", \"wb\") as fp:\n",
+    "    pickle.dump(total_median_dict, fp)\n",
+    "\n",
+    "# save dict of only detected genes' medians    \n",
+    "detected_median_dict = {k: v for k, v in total_median_dict.items() if not math.isnan(v)}\n",
+    "with open(f\"/path/to/detected_gene_median_dict.pickle\", \"wb\") as fp:\n",
+    "    pickle.dump(detected_median_dict, fp)"
+   ]
+  },
+  {
+   "cell_type": "markdown",
+   "id": "e8e17ad6-79ac-4f34-aa0c-1eaa1bace2e5",
+   "metadata": {
+    "tags": []
+   },
+   "source": [
+    "### The below code displays some characteristics of the genes detected in the pretraining corpus."
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 38,
+   "id": "decent-switzerland",
+   "metadata": {},
+   "outputs": [],
+   "source": [
+    "gene_detection_counts_dict = {k: v.size() for k, v in total_tdigest_dict.items()}"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 44,
+   "id": "polished-innocent",
+   "metadata": {},
+   "outputs": [
+    {
+     "name": "stderr",
+     "output_type": "stream",
+     "text": [
+      "/home1/ct68/miniconda3/lib/python3.8/site-packages/seaborn/distributions.py:2557: FutureWarning: `distplot` is a deprecated function and will be removed in a future version. Please adapt your code to use either `displot` (a figure-level function with similar flexibility) or `histplot` (an axes-level function for histograms).\n",
+      "  warnings.warn(msg, FutureWarning)\n"
+     ]
+    },
+    {
+     "data": {
+      "image/png": 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+      "text/plain": [
+       "<Figure size 1500x750 with 1 Axes>"
+      ]
+     },
+     "metadata": {
+      "needs_background": "light"
+     },
+     "output_type": "display_data"
+    }
+   ],
+   "source": [
+    "gene_detection_counts = [i for i in gene_detection_counts_dict.values()]\n",
+    "import seaborn as sns\n",
+    "import matplotlib.pyplot as plt\n",
+    "plt.figure(figsize=(10,5), dpi=150)\n",
+    "plt.rcParams.update({'font.size': 18})\n",
+    "count_plot = sns.distplot(gene_detection_counts).set_title(f\"# Cells Expressing Each\\nProtein-Coding or miRNA Gene\")"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 47,
+   "id": "missing-bradley",
+   "metadata": {},
+   "outputs": [
+    {
+     "data": {
+      "text/plain": [
+       "27454"
+      ]
+     },
+     "execution_count": 47,
+     "metadata": {},
+     "output_type": "execute_result"
+    }
+   ],
+   "source": [
+    "len(gene_detection_counts)"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 55,
+   "id": "perfect-signal",
+   "metadata": {},
+   "outputs": [
+    {
+     "data": {
+      "text/plain": [
+       "25424"
+      ]
+     },
+     "execution_count": 55,
+     "metadata": {},
+     "output_type": "execute_result"
+    }
+   ],
+   "source": [
+    "len([i for i in gene_detection_counts if i > 0])"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 56,
+   "id": "faced-theory",
+   "metadata": {},
+   "outputs": [
+    {
+     "data": {
+      "text/plain": [
+       "22735"
+      ]
+     },
+     "execution_count": 56,
+     "metadata": {},
+     "output_type": "execute_result"
+    }
+   ],
+   "source": [
+    "len([i for i in gene_detection_counts if i > 100])"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 57,
+   "id": "tough-workplace",
+   "metadata": {},
+   "outputs": [
+    {
+     "data": {
+      "text/plain": [
+       "21167"
+      ]
+     },
+     "execution_count": 57,
+     "metadata": {},
+     "output_type": "execute_result"
+    }
+   ],
+   "source": [
+    "len([i for i in gene_detection_counts if i > 1000])"
+   ]
+  },
+  {
+   "cell_type": "code",
+   "execution_count": 49,
+   "id": "cooperative-camcorder",
+   "metadata": {},
+   "outputs": [
+    {
+     "data": {
+      "text/plain": [
+       "173152.0299000284"
+      ]
+     },
+     "execution_count": 49,
+     "metadata": {},
+     "output_type": "execute_result"
+    }
+   ],
+   "source": [
+    "gene_detection_event_digest = crick.tdigest.TDigest()\n",
+    "gene_detection_event_digest.update(gene_detection_counts)\n",
+    "gene_detection_event_digest.quantile(0.5)"
+   ]
+  }
+ ],
+ "metadata": {
+  "kernelspec": {
+   "display_name": "Python 3 (ipykernel)",
+   "language": "python",
+   "name": "python3"
+  },
+  "language_info": {
+   "codemirror_mode": {
+    "name": "ipython",
+    "version": 3
+   },
+   "file_extension": ".py",
+   "mimetype": "text/x-python",
+   "name": "python",
+   "nbconvert_exporter": "python",
+   "pygments_lexer": "ipython3",
+   "version": "3.10.11"
+  }
+ },
+ "nbformat": 4,
+ "nbformat_minor": 5
+}